Federal Register/Vol. 70, No. 213/Friday, November 4, 2005/Notices
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
D-Phenothrin
United States Prevention, Pesticides Environmental Protection and Toxic Substances September 2008 Agency (7508P) Reregistration Eligibility Decision for d-Phenothrin September 2008 Reregistration Eligibility Decision for Phenothrin List A Case No. 0426 2 Glossary of Terms and Abbreviations ae Acid Equivalent ai Active Ingredient CFR Code of Federal Regulations CSF Confidential Statement of Formula DCI Data Call-In EDWC Estimated Drinking Water Concentration EEC Estimated Environmental Concentration EIIS Ecological Incident Information System EPA Environmental Protection Agency EUP End-Use Product FDA Food and Drug Administration FIFRA Federal Insecticide, Fungicide, and Rodenticide Act FFDCA Federal Food, Drug, and Cosmetic Act FQPA Food Quality Protection Act LC50 Median Lethal Concentration. A statistically derived concentration of a substance that can be expected to cause death in 50% of test animals. It is usually expressed as the weight of substance per weight or volume of water, air or feed, e.g., mg/l, mg/kg or ppm. LD50 Median Lethal Dose. A statistically derived single dose that can be expected to cause death in 50% of the test animals when administered by the route indicated (oral, dermal, inhalation). It is expressed as a weight of substance per unit weight of animal, e.g., mg/kg. LOC Level of Concern LOAEL Lowest Observed Adverse Effect Level mg/kg/day Milligram Per Kilogram Per Day mg/L Milligrams Per Liter MOE Margin of Exposure MRID Master Record Identification (number). EPA's system of recording and tracking studies submitted. -
(12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al
US 200601 10428A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 de Juan et al. (43) Pub. Date: May 25, 2006 (54) METHODS AND DEVICES FOR THE Publication Classification TREATMENT OF OCULAR CONDITIONS (51) Int. Cl. (76) Inventors: Eugene de Juan, LaCanada, CA (US); A6F 2/00 (2006.01) Signe E. Varner, Los Angeles, CA (52) U.S. Cl. .............................................................. 424/427 (US); Laurie R. Lawin, New Brighton, MN (US) (57) ABSTRACT Correspondence Address: Featured is a method for instilling one or more bioactive SCOTT PRIBNOW agents into ocular tissue within an eye of a patient for the Kagan Binder, PLLC treatment of an ocular condition, the method comprising Suite 200 concurrently using at least two of the following bioactive 221 Main Street North agent delivery methods (A)-(C): Stillwater, MN 55082 (US) (A) implanting a Sustained release delivery device com (21) Appl. No.: 11/175,850 prising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more (22) Filed: Jul. 5, 2005 bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more Related U.S. Application Data bioactive agents Subretinally; and (60) Provisional application No. 60/585,236, filed on Jul. (C) instilling (e.g., injecting or delivering by ocular ion 2, 2004. Provisional application No. 60/669,701, filed tophoresis) one or more bioactive agents into the Vit on Apr. 8, 2005. reous humor of the eye. Patent Application Publication May 25, 2006 Sheet 1 of 22 US 2006/0110428A1 R 2 2 C.6 Fig. -
When Endocrine Abnormalities Are a Medication Side Effect
When Endocrine Abnormalities are a Medication Side Effect Donald Beckstead, MD T. Grant Phillips, MD Michael Geishauser, PharmD UPMC Altoona Family Physicians 1 DISCLOSURES • Sadly, we have nothing to disclose 2 OBJECTIVES • Identify commonly used drugs that may cause new endocrine abnormalities • Discuss mechanisms for development of such abnormalities • Touch on risk factors for the development of some medication induced endocrine abnormalities • Mention principles to guide work‐up and treatment 3 THYROID AND DRUGS 4 Amiodarone • Can cause hyper‐ or hypothyroidism • One amiodarone molecule contains two atoms of iodine • Amiodarone has 75 mg iodine/tablet • 6 mg released into circulation • WHO recommendation 150 mcg/day I2 5 Amiodarone • Clinically significant thyroid dysfunction occurs 5‐15% • Risk factors for hypothyroidism: – Female – Positive thyroid antibody – Residence in an iodine‐repleted region • Thyrotoxicosis 2‐12% – Risk factors: male, iodine deficient region 6 Amiodarone • Iodine deficient: Hyperthyroid • Iodine excess: Hypothyroid 7 Lithium • Once used as an antithyroid drug • 1‐3% people develop goiter • May precipitate undiagnosed autoimmune thyroid disorders • Can block thyroid hormone release from thyroglobulin 8 PPIs • Raise gastric pH • Certain level of stomach acid necessary for ingestion of thyroxine (dissolve pills) • TSH increased with PPI treatment • Reduce absorption by reducing dissolution of pills • Liquid formulation may solve problem 9 Miscellaneous Drugs • Thyroid hormone is actively oxidized and conjugated -
NINDS Custom Collection II
ACACETIN ACEBUTOLOL HYDROCHLORIDE ACECLIDINE HYDROCHLORIDE ACEMETACIN ACETAMINOPHEN ACETAMINOSALOL ACETANILIDE ACETARSOL ACETAZOLAMIDE ACETOHYDROXAMIC ACID ACETRIAZOIC ACID ACETYL TYROSINE ETHYL ESTER ACETYLCARNITINE ACETYLCHOLINE ACETYLCYSTEINE ACETYLGLUCOSAMINE ACETYLGLUTAMIC ACID ACETYL-L-LEUCINE ACETYLPHENYLALANINE ACETYLSEROTONIN ACETYLTRYPTOPHAN ACEXAMIC ACID ACIVICIN ACLACINOMYCIN A1 ACONITINE ACRIFLAVINIUM HYDROCHLORIDE ACRISORCIN ACTINONIN ACYCLOVIR ADENOSINE PHOSPHATE ADENOSINE ADRENALINE BITARTRATE AESCULIN AJMALINE AKLAVINE HYDROCHLORIDE ALANYL-dl-LEUCINE ALANYL-dl-PHENYLALANINE ALAPROCLATE ALBENDAZOLE ALBUTEROL ALEXIDINE HYDROCHLORIDE ALLANTOIN ALLOPURINOL ALMOTRIPTAN ALOIN ALPRENOLOL ALTRETAMINE ALVERINE CITRATE AMANTADINE HYDROCHLORIDE AMBROXOL HYDROCHLORIDE AMCINONIDE AMIKACIN SULFATE AMILORIDE HYDROCHLORIDE 3-AMINOBENZAMIDE gamma-AMINOBUTYRIC ACID AMINOCAPROIC ACID N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491) AMINOGLUTETHIMIDE AMINOHIPPURIC ACID AMINOHYDROXYBUTYRIC ACID AMINOLEVULINIC ACID HYDROCHLORIDE AMINOPHENAZONE 3-AMINOPROPANESULPHONIC ACID AMINOPYRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE AMINOTHIAZOLE AMIODARONE HYDROCHLORIDE AMIPRILOSE AMITRIPTYLINE HYDROCHLORIDE AMLODIPINE BESYLATE AMODIAQUINE DIHYDROCHLORIDE AMOXEPINE AMOXICILLIN AMPICILLIN SODIUM AMPROLIUM AMRINONE AMYGDALIN ANABASAMINE HYDROCHLORIDE ANABASINE HYDROCHLORIDE ANCITABINE HYDROCHLORIDE ANDROSTERONE SODIUM SULFATE ANIRACETAM ANISINDIONE ANISODAMINE ANISOMYCIN ANTAZOLINE PHOSPHATE ANTHRALIN ANTIMYCIN A (A1 shown) ANTIPYRINE APHYLLIC -
RR Program's RCL Spreadsheet Update
RR Program’s RCL Spreadsheet Update March 2017 RR Program RCL Spreadsheet Update DNR-RR-052e The Wisconsin DNR Remediation and Redevelopment Program (RR) has updated the numerical soil standards in the August 2015 DNR-RR- 052b RR spreadsheet of residual contaminant levels (RCLs). The RCLs were determined using the U.S. EPA RSL web- calculator by accepting EPA exposure defaults, with the exception of using Chicago, IL, for the climatic zone. This documentThe U.S. provides EPA updateda summary its Regionalof changes Screening to the direct-contact Level (RSL) RCLs website (DC-RCLs) in June that2015. are To now reflect in the that March 2017 spreadsheet.update, the The Wisconsin last page ofDNR this updated document the has numerical the EPA exposuresoil standards, parameter or residual values usedcontaminant in the RCL levels calculations. (RCLs), in the Remediation and Redevelopment program’s spreadsheet of RCLs. This document The providesU.S. EPA a RSL summary web-calculator of the updates has been incorporated recently updated in the Julyso that 2015 the spreadsheet.most up-to-date There toxicity were values no changes for chemi - cals madewere certainlyto the groundwater used in the RCLs,RCL calculations. but there are However, many changes it is important in the industrial to note that and the non-industrial web-calculator direct is only a subpartcontact of the (DC) full RCLsEPA RSL worksheets. webpage, Tables and that 1 andthe other 2 of thissubparts document that will summarize have important the DC-RCL explanatory changes text, generic tablesfrom and the references previous have spreadsheet yet to be (Januaryupdated. -
(12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness Et Al
USOO6264,917B1 (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness et al. (45) Date of Patent: Jul. 24, 2001 (54) TARGETED ULTRASOUND CONTRAST 5,733,572 3/1998 Unger et al.. AGENTS 5,780,010 7/1998 Lanza et al. 5,846,517 12/1998 Unger .................................. 424/9.52 (75) Inventors: Jo Klaveness; Pál Rongved; Dagfinn 5,849,727 12/1998 Porter et al. ......................... 514/156 Lovhaug, all of Oslo (NO) 5,910,300 6/1999 Tournier et al. .................... 424/9.34 FOREIGN PATENT DOCUMENTS (73) Assignee: Nycomed Imaging AS, Oslo (NO) 2 145 SOS 4/1994 (CA). (*) Notice: Subject to any disclaimer, the term of this 19 626 530 1/1998 (DE). patent is extended or adjusted under 35 O 727 225 8/1996 (EP). U.S.C. 154(b) by 0 days. WO91/15244 10/1991 (WO). WO 93/20802 10/1993 (WO). WO 94/07539 4/1994 (WO). (21) Appl. No.: 08/958,993 WO 94/28873 12/1994 (WO). WO 94/28874 12/1994 (WO). (22) Filed: Oct. 28, 1997 WO95/03356 2/1995 (WO). WO95/03357 2/1995 (WO). Related U.S. Application Data WO95/07072 3/1995 (WO). (60) Provisional application No. 60/049.264, filed on Jun. 7, WO95/15118 6/1995 (WO). 1997, provisional application No. 60/049,265, filed on Jun. WO 96/39149 12/1996 (WO). 7, 1997, and provisional application No. 60/049.268, filed WO 96/40277 12/1996 (WO). on Jun. 7, 1997. WO 96/40285 12/1996 (WO). (30) Foreign Application Priority Data WO 96/41647 12/1996 (WO). -
State of Maine Department of Agriculture, Conservation and Forestry Board of Pesticides Control 28 State House Station Augusta, Maine 04333 Paul R
STATE OF MAINE DEPARTMENT OF AGRICULTURE, CONSERVATION AND FORESTRY BOARD OF PESTICIDES CONTROL 28 STATE HOUSE STATION AUGUSTA, MAINE 04333 PAUL R. LEPAGE WALTER E. WHITCOMB GOVERNOR COMMISSIONER Memorandum To: Board of Pesticides Control From: Pam Bryer, Toxicologist Subject: Question from June 6, 2018 Board Meeting Date: May 18, 2018 At the June 6, 2018 board meeting the question of whether Bt is toxic to lobsters was asked. Here is a brief answer to that question. Not surprisingly, the answer is we don’t know. Question: Is Bt harmful to lobsters? Answer: Bt has not been tested on lobsters. Attached is a table based on available pesticide toxicity data for lobsters. Few compounds have been tested on any species of lobsters. Both lobsters and Bt are fairly unique entities so generalizations are not helpful in extrapolating to other pesticides exposure scenarios. Reasonable follow-up question: Since Bt targets insects and lobsters are closely related can we assume that lobsters would be just as sensitive? Answer: Typically, shared phylogeny could help predict toxicity, however, the marine environment places a different set of physical constraints on digestive physiology and since Bt is a stomach poison we should not speculate. Marine organisms typically have modified intestinal tracts to deal with maintaining the homeostatic balance of outside-saltwater to internal-body composition. PHONE: (207) 287-2731 32 BLOSSOM LANE, MARQUARDT BUILDING WWW.THINKFIRSTSPRAYLAST.ORG The above figure shows the uptake of Bt endospore into the larval gut demonstrating how Bt’s mechanism of action centers around cells lining the intestinal tract. Table 1. Preliminary literature search results on the toxicity of pesticides on lobsters (Homarus spp) Contaminant Concentration Duration Experimental Primary Effects Source (ug/L) Notes Organochlorines Endosulfan -decr survival & metamorphosis Bauer et al. -
Gynecomastia — a Difficult Diagnostic Problem Ginekomastia — Trudny Problem Diagnostyczny
SZKOLENIE PODYPLOMOWE/POSTGRADUATE EDUCATION Endokrynologia Polska/Polish Journal of Endocrinology Tom/Volume 62; Numer/Number 2/2011 ISSN 0423–104X Gynecomastia — a difficult diagnostic problem Ginekomastia — trudny problem diagnostyczny Marek Derkacz1, Iwona Chmiel-Perzyńska2, Andrzej Nowakowski1 1Department of Endocrinology, Medical University, Lublin, Poland 2Department of Family Medicine, Medical University, Lublin, Poland Abstract Gynecomastia is a benign, abnormal, growth of the male breast gland which can occur unilaterally or bilaterally, resulting from a prolife- ration of glandular, fibrous and adipose tissue. Gynecomastia is characterised by the presence of soft, 2–4 cm in diameter, usually discus- shaped enlargement of tissues under the nipple. It is estimated that this pathology occurs in 32–65% of men over the age of 17. Gynecoma- stia is a psychosocial problem and may lead to a perceived lowering of quality of life. The main cause of gynecomastia is a loss of equilibrium between oestrogens and androgens. Increased sensitivity for oestrogens of the breast gland, or local factors (e.g. an excessive synthesis of oestrogens in breast tissues or changes in oestrogen and androgen receptors) may cause gynecomastia. Also, prolactin, thyroxine, cortisol, human chorionic gonadotropin, leptin and receptors for human chorionic gonadotropin, prolactin and luteinizing hormone localised in tissues of the male breast may participate in the etiopathogenesis of gyneco- mastia. Usually three types of gynecomastia are distinguished: physiological, idiopathic and pathological gynecomastia. The latter is the consequ- ence of relative or absolute excess of oestrogens. In this paper, frequent as well as casuistic causes of gynecomastia will be described. A diagnosis of gynecomastia is usually possible after a palpation examination. -
Pesticides EPA 738-R-06-003 Environmental Protection and Toxic Substances June 2006 Agency (7508C)
United States Prevention, Pesticides EPA 738-R-06-003 Environmental Protection and Toxic Substances June 2006 Agency (7508C) Reregistration Eligibility Decision for Resmethrin 1 REREGISTRATION ELIGIBILITY DECISION for Resmethrin List A Case No. 0421 Approved by: ______________________ Debra Edwards, Ph.D. Director, Special Review and Reregistration Division ________________________ Date 2 Table of Contents Executive Summary ......................................................................................................8 I. Introduction ............................................................................................................ 15 I. Introduction ............................................................................................................ 15 II. Chemical Overview ................................................................................................ 16 A. Regulatory History ............................................................................................ 16 B. Chemical Identification ................................................................................... 17 C. Resmethrin Use Profile.................................................................................... 17 III. Summary of Resmethrin Risk Assessments........................................................ 19 A. Human Health Risk Assessment ....................................................................... 19 1. Toxicity........................................................................................................... -
Pesticides Contamination of Cereals and Legumes: Monitoring of Samples Marketed in Italy As a Contribution to Risk Assessment
applied sciences Article Pesticides Contamination of Cereals and Legumes: Monitoring of Samples Marketed in Italy as a Contribution to Risk Assessment Valeria Nardelli 1, Valeria D’Amico 1, Mariateresa Ingegno 1 , Ines Della Rovere 1, Marco Iammarino 1,* , Francesco Casamassima 1, Anna Calitri 1, Donatella Nardiello 2 , Donghao Li 3 and Maurizio Quinto 2,3,* 1 Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata, Via Manfredonia 20, 71121 Foggia, Italy; [email protected] (V.N.); [email protected] (V.D.); [email protected] (M.I.); [email protected] (I.D.R.); [email protected] (F.C.); [email protected] (A.C.) 2 Dipartimento di Scienze Agrarie, Alimenti, Risorse Naturali e Ingegneria—Università degli Studi di Foggia, Via Napoli, 25, 71122 Foggia, Italy; [email protected] 3 Department of Chemistry, Yanbian University, Park Road 977, Yanji 133002, China; [email protected] * Correspondence: [email protected] (M.I.); [email protected] (M.Q.) Featured Application: This work offers a contribution to risk assessment regarding the levels of 37 pesticides in cereal and legume samples commercialized in Italy during the last years. It is well-known that prolonged exposure to pesticides can increase the risk of cardiovascular and respiratory disease, other than promoting cancer diseases. Thus, the World Health Organization and the European Food Safety Authority ask for monitoring of the levels of such substances, Citation: Nardelli, V.; D’Amico, V.; especially in vegetables, continuously, to have availability updated and detailed data on this Ingegno, M.; Della Rovere, I.; Iammarino, M.; Casamassima, F.; type of food contamination. -
Pests of the Flower Garden Phillip E
Pests of the Flower Garden Phillip E. Sloderbeck Entomologist Southwest Area Office This publication is meant to help ent names. One of the more popular prey, predators and parasites. It is im- gardeners select insecticides for use groups of insecticides labeled for portant to select and use insecticides in flower gardens. It lists some of the home use are the pyrethroids, which carefully. common pests associated with flow- come in a variety of names such as When selecting insecticides, buy in ers and some of the active ingredients bifenthrin, cyfluthrin, permethrin and quantities that can be used in a reason- found in insecticides labeled for use esefenvalerate. Many of these com- able amount of time. Look for prod- on ornamental plants. The list contains pounds end in “-thrin,” but not all. ucts that can be used for more than common active ingredients for each Many have a broad spectrum, but the one pest. For example, if a gardener pest from the Kansas pesticide data- lists of pests controlled by each pyre- has problems with aphids and mealy- base. Other effective materials may throid varies. bugs, it might be best to buy a product also be available. Gardeners should Remember that to be a pest, insects that controls both rather than buying check labels carefully and visit local have to be present in substantial num- separate products for each pest. Re- retail outlets to determine which prod- bers. Spotting one or two insects in a member that if it is necessary to treat ucts are best suited for a particular garden should not trigger an insecti- pests several times during the season, pest problem. -
2019 Minnesota Chemicals of High Concern List
Minnesota Department of Health, Chemicals of High Concern List, 2019 Persistent, Bioaccumulative, Toxic (PBT) or very Persistent, very High Production CAS Bioaccumulative Use Example(s) and/or Volume (HPV) Number Chemical Name Health Endpoint(s) (vPvB) Source(s) Chemical Class Chemical1 Maine (CA Prop 65; IARC; IRIS; NTP Wood and textiles finishes, Cancer, Respiratory 11th ROC); WA Appen1; WA CHCC; disinfection, tissue 50-00-0 Formaldehyde x system, Eye irritant Minnesota HRV; Minnesota RAA preservative Gastrointestinal Minnesota HRL Contaminant 50-00-0 Formaldehyde (in water) system EU Category 1 Endocrine disruptor pesticide 50-29-3 DDT, technical, p,p'DDT Endocrine system Maine (CA Prop 65; IARC; IRIS; NTP PAH (chem-class) 11th ROC; OSPAR Chemicals of Concern; EuC Endocrine Disruptor Cancer, Endocrine Priority List; EPA Final PBT Rule for 50-32-8 Benzo(a)pyrene x x system TRI; EPA Priority PBT); Oregon P3 List; WA Appen1; Minnesota HRV WA Appen1; Minnesota HRL Dyes and diaminophenol mfg, wood preservation, 51-28-5 2,4-Dinitrophenol Eyes pesticide, pharmaceutical Maine (CA Prop 65; IARC; NTP 11th Preparation of amino resins, 51-79-6 Urethane (Ethyl carbamate) Cancer, Development ROC); WA Appen1 solubilizer, chemical intermediate Maine (CA Prop 65; IARC; IRIS; NTP Research; PAH (chem-class) 11th ROC; EPA Final PBT Rule for 53-70-3 Dibenzo(a,h)anthracene Cancer x TRI; WA PBT List; OSPAR Chemicals of Concern); WA Appen1; Oregon P3 List Maine (CA Prop 65; NTP 11th ROC); Research 53-96-3 2-Acetylaminofluorene Cancer WA Appen1 Maine (CA Prop 65; IARC; IRIS; NTP Lubricant, antioxidant, 55-18-5 N-Nitrosodiethylamine Cancer 11th ROC); WA Appen1 plastics stabilizer Maine (CA Prop 65; IRIS; NTP 11th Pesticide (EPA reg.