About ISEH
The mission of ISEH is to promote the scientific knowledge and clinical application of basic hematology, immunology, stem cell research, cell and gene therapy, and all related aspects through research, publications, discussion, support of new investigators and organization of scientific meetings.
President's Message
I would like to thank you all for your support, and for the opportunity to serve as President of ISEH. This is a true honor and I promise to work hard to continue to build our society stronger.
First, I would like to thank our past president, Timm Schroeder, and the Executive Committee and Board of Directors, for leading our society skillfully last year. By all measures, ISEH is in great shape, and we owe that to all of you for your contributions. I would also like to express particular thanks to Kim Eskew who served as the Executive Director of ISEH for the past seven years. Kim’s hard work has been instrumental in making our society blossom. While we will miss having Kim with ISEH, we wish her best of luck in her new endeavors.
Last year was record breaking in many respects. We had a fantastically successful annual meeting in Frankfurt, with record-breaking registrants (490) and abstract submissions (328). Thanks to all of you, the scientific quality of the meeting was outstanding. Not to mention the dance party, which is always one of the highlights of the meeting!
I encourage all of you to prepare to attend next year’s meeting, which will be held August 23- 26 in Los Angeles, at the beautiful new UCLA Luskin Conference Center. We have an exciting scientific program lined up, which is complemented by the popular pre-meeting workshop for trainees, as well as other fun networking activities, including a new “job market” for post-doc applicants. This year we hope to put additional emphasis on the needs of the new PIs who are just building their own independent research groups. Stay tuned for more updates about the program! I also hope you can plan an extra day or two to visit the many wonderful attractions that Los Angeles and Southern California have to offer.
This also is an exciting time for our society’s journal, Experimental Hematology. Thanks to the outstanding job of our past Editor-in-Chief, Keith Humphries, the impact factor of Experimental Hematology is now on the upswing! Our new Editor-in-Chief, Connie Eaves, stepped on board in the spring, and is already putting all her energy and enthusiasm to make the journal even stronger. This is a great time to submit your work to Experimental Hematology and take advantage of the rapid manuscript processing and the many perks for ISEH members.
At ISEH, we like to honor our colleagues for their outstanding contributions to the field. I would like to remind you that this is the final day to submit nominations for the Metcalf and McCulloch & Till Awards. Remember, only members can be nominated, and only members can nominate. If you are not currently an ISEH member, this is a good time to take advantage of the discounted multi-year membership rate. I hope that you will make your voice heard by nominating and voting for your colleagues!
Please don’t hesitate to contact us if you would like to be more involved in the society’s activities, or have new ideas how we can serve our members needs better. I look forward to staying in touch, and seeing you in Los Angeles next year!
Sincerely,
Hanna Mikkola ISEH President
New Investigators Digest
Why Belong to ISEH? New Investigators Share Their Thoughts
Following the 2017 International Society of Experimental Hematology (ISEH) Annual Scientific Meeting in Frankfurt, you may be looking to engage even more and maximize your ISEH membership. We asked members of the ISEH New Investigators Committee (NIC) why they belong to ISEH. Here's what we heard...
Isabel Beerman (NIH, USA) added “One of the most valuable aspects of my ISEH membership is the access to the network of outstanding researchers. This is highlighted at the annual meeting. This intimate gathering promotes interactions with investigators at all career stages and allows for open discussions of developing research programs. In addition, interactions between members is fostered throughout the year by ISEH sponsored events on the website that highlight relevant publications and provide great educational opportunities from the introduction to hematology (Hematology 101) to learning about emerging technologies driving the field forward (New Investigators Committee Webinars).”
Nina Cabezas-Wallscheid (Max Planck Institute Freiburg, Germany) also told us “I attended my first ISEH meeting after it was recommended by Mick Milsom in 2012. I enjoyed the conference so much that since then I have joined every year. Why? Because I believe that the ISEH community provides each scientist, from junior to senior, a niche to interact and collaborate to drive the hematological field forwards. In addition, I find that ISEH has an extremely important task driving young investigators to top level science and enrolling well- established scientists in this process. I believe that this is partially achieved by keeping the size of the Annual meeting small. Moreover the ISEH community organize state-of-the-art Webinars, journal clubs and keep scientists updated on the latest news through several platforms such as Facebook, Connections, and Simply Blood.”
Click here to read more on the ISEH website
News from the Field
Novartis submits application to FDA for KymriahTM (tisagenlecleucel) in adult patients with r/r DLBCL, seeking second indication for first-ever FDA approved CAR-T therapy Novartis
Six papers by disgraced surgeon should be retracted, report concludes Science
Omeros Reports Additional and Consistently Positive Data for OMS721 in Patients with Hematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy Omeros Press Release
Don't Miss Sessions
51st Miami Winter Symposium: Stem Cells - Today's Research Tomorrow's Therapy 28-31 January 2018 Miami, Florida, USA
2018 BMT Tandem Meetings 21-25 February 2018 Salt Lake City, Utah, USA
7th New Directions in Leukaemia Research Meeting 25-28 March 2018 Queensland, Australia
Click here to read more on the ISEH website
Member Profile
Meet ISEH New Investigators Committee Member Isabel Beerman
Isabel Beerman is a principle investigator at the National Institute on Aging – part of the U.S Department of Health & Human Services. Her work is focused on understanding the mechanisms driving age-associated loss of potential in aged stem cells. Isabel has degrees from both Harvard and Yale University and completed her post-doc under Dr. Derrick Rossi at Boston Children’s Hospital. Her areas of expertise are Hematopoietic Stem Cells, Aging, and Epigenetics.
Dr. Beerman currently serves as an active member of the New Investigators Committee and played an integral role in the planning of the Meet the Expert Mixer and the New Investigators Technology
Workshop at the 46th Annual Scientific Meeting. She has been a member of ISEH for four years.
How did you find your way to the hematology and stem cells scientific field?
Although my PhD training was in Genetics, I heard a captivating talk about aging stem cells by a faculty candidate, Dr. Derrick Rossi, and was motivated to venture into HSC research. This was almost a return “home” scientifically for me, as I was introduced to hematopoietic stem cell biology while doing a high-school summer internship at the McLaughlin Research Institute.
And then how were you introduced to ISEH?
Studying HSC biology, I was introduced to ISEH initially through reading hematology publications in Experimental Hematology. The first annual meeting I attended was in Montreal, Canada.
Click here to read more on the ISEH website
Society News
2018 Call for Awards - Last Chance
ISEH members have the opportunity to nominate a fellow ISEH member for one of two prestigious awards that acknowledge those dedicated to the advancement of scientific research: the Donald Metcalf Award and the McCulloch & Till Award.
Click here to learn more and submit your nominations.
2018 Membership Renewal Now Open
ISEH is the perfect forum for scientific veterans, visionaries and up-and-coming new investigators to collaborate and advance the field of experimental hematology. When you join ISEH, you are a part of a dedicated, approachable, and select group of individuals.
Click here to renew your membership
New Hematology 101 Module Available
Launched last year, Hematology 101 brought together leading experts from within the ISEH community to help articulate the major themes in hematology and to review the most important tools used to define stem cells and their progenyWe are excited to announce the release of our latest module – HSCs and Disease.
This new release includes presentations from these ISEH members: Timothy J. Ley, MD Dita Gratzinger, MD, PhD Luigi Naldini, MD, PhD Andrew Elefanty, MD, PhD
Click here to access Hematology 101
Experimental Hematology
Please note the following changes related to Experimental Hematology, which will take effect on Jan 1, 2018:
Manuscript submission: Page fees and color-in print fees will no longer apply (a submission fee of $50.00 USD for non-ISEH members will still apply). · Subscriptions Experimental Hematology will be available electronically only. No print subscription option will be available.
November
Obituary
Tessa Laurie Holyoake, (March 17, 1963 – August 30, 2017): Remembering a life that knew no boundaries Connie J. Eaves Review
The microenvironment in myelodysplastic syndromes: Niche-mediated disease initiation and progression Allison J. Li, Laura M. Calvin
Genomics/Proteomics of Hematopoiesis
Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes Jin Zhang, Malachi Griffith, Christopher A. Miller, Obi L. Griffith, David H. Spencer, Jason R. Walker, Vincent Magrini, Sean D. McGrath, Amy Ly, Nichole M. Helton, Maria Trissal, Daniel C. Link, Ha X. Dang, David E. Larson, Shashikant Kulkarni, Matthew G. Cordes, Catrina C. Fronick, Robert S. Fulton, Jeffery M. Klco, Elaine R. Mardis, Timothy J. Ley, Richard K. Wilson, Christopher A. Maher
Stem Cells
Signaling via Smad2 and Smad3 is dispensable for adult murine hematopoietic stem cell function in vivo Matilda Billing, Emma Rörby, Maria Dahl, Ulrika Blank, Silja Andradottír, Mats Ehinger, Stefan Karlsson
Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells Katharina Senger, Gina Marka, Karin Soller, Vadim Sakk, Maria Carolina Florian, Hartmut Geiger Malignant Hematopoiesis
Tet2 restrains inflammatory gene expression in macrophages Alyssa H. Cull, Brooke Snetsinger, Rena Buckstein, Richard A. Wells, Michael J. Rauh
Genetic risk of prediabetes and diabetes development in chronic myeloid leukemia patients treated with nilotinib Bruno Martino, Corrado Mammì, Claudia Labate, Silvia Rodi, Domenica Ielo, Manuela Priolo, Maurizio Postorino, Giovanni Tripepi, Francesca Ronco, Carmelo Laganà, Caterina Musolino, Marianna Greco, Giorgio La Nasa, Giovanni Caocci
The oligodendrocyte lineage transcription factor 2 (OLIG2) is epigenetically regulated in acute myeloid leukemia Arzu Yalcin, Marlon Kovarbasic, Julius Wehrle, Rainer Claus, Heiko Becker, Mahmoud Abdelkarim, Verena I. Gaidzik, Andrea Schmidts, Ralph Wäsch, Heike L. Pahl, Konstanze Döhner, Lars Bullinger, Justus Duyster, Michael Lübbert, Björn Hackanson
December
Perspective
The slippery slope of hematopoietic stem cell aging Martin Wahlestedt, David Bryder
Normal Hematopoiesis
MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice Claudine S. Kadmon, Cameron T. Landers, Haiyan S. Li, Stephanie S. Watowich, Antony Rodriguez, Katherine Y. King
Thermal injury of the skin induces G-CSF-dependent attenuation of EPO-mediated STAT signaling and erythroid differentiation arrest in mice John G. Noel, Benjamin J. Ramser, Jose A. Cancelas, Francis X. McCormack, Jason C. Gardner
Stem Cells
Effects of in vivo deletion of GATA2 in bone marrow stromal cells Shin Hasegawa, Tohru Fujiwara, Yoko Okitsu, Hiroki Kato, Yuki Sato, Noriko Fukuhara, Yasushi Onishi, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae
Genomics/Proteomics of Hematopoiesis
Lenalidomide modulates gene expression in human ABC-DLBCL cells by regulating IKAROS interaction with an intronic control region of SPIB Lauren A. Solomon, Carolina R. Batista, Rodney P. DeKoter
Malignant Hematopoiesis
Identification of novel biomarkers for MLL-translocated acute myeloid leukemia Karine Lagacé, Fréderic Barabé, Josée Hébert, Sonia Cellot, Brian T. Wilhelm
Immunobiology and Immunotherapy
PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo Terence A. McGonigle, Amy R. Dwyer, Eloise L. Greenland, Naomi M. Scott, Kevin N. Keane, Philip Newsholme, Helen S. Goodridge, Leonard I. Zon, Fiona J. Pixley, Prue H. Hart
Click here to read more on the ISEH website
Jobs
Postdoctoral Position in Hematopoietic Stem Cell Biology University of California Santa Cruz California, USA
The laboratory of Professor Camilla Forsberg at the University of California Santa Cruz encourages applications by ambitious recent PhD graduates interested in hematopoietic stem cell biology. Focus areas include Cell fate in adult hematopoiesis; Epigenetic regulation of stem cell fate; Developmental hematopoiesis; Hematopoietic stem cell trafficking, as well as new endeavors in stem cell engineering. The University of California Santa Cruz is located on the central coast of California, USA, in close proximity to Stanford University, UC San Francisco, UC Berkeley, and the San Francisco Bay Area biotechnology community. Spousal/partner hires in neighboring labs will be coordinated upon request.
Click here to read more on the ISEH website
Faculty Positions at the University of California Santa Cruz University of California Santa Cruz California, USA
Two positions at the Assistant Professor level are available in the Department of Molecular, Cell, and Developmental Biology at the University of California Santa Cruz.
Click here to read more on the ISEH website
Postdoc Position Available Cedars-Sinai Medical Center Los Angeles, USA
Mechanisms of Myeloid Cell Differentiation and Functional Programming Cedars-Sinai Medical Center, Los Angeles Helen Goodridge PhD is looking for a postdoctoral scientist to join her team at Cedars-Sinai Medical Center, Los Angeles to study mechanisms underlying the differentiation and functional programming of monocytes and neutrophils, building on the lab’s previous studies of myelopoiesis (including Blood, 2015 and Immunity, in press). Candidates should have an interest and prior expertise in immunology and/or hematology, with strong experience of flow cytometry, tissue culture, molecular biology (e.g. RNA-seq, ChIP, DNA barcoding) and rodent studies (e.g. adoptive transfer, bone marrow transplantation). Bioinformatics/computational experience would be an advantage.
The Goodridge lab, which is located in the Cedars-Sinai Regenerative Medicine Institute and affiliated with the Cedars-Sinai Research Division of Immunology, studies the production and functional programming of myeloid cells (neutrophils, monocytes, macrophages and DCs), and their roles in infectious and inflammatory diseases, aging and tissue regeneration.
Click here to read more on the ISEH website
Members' Corner
Congrats to these ISEH members:
Feng Liu, Lu Wang, Dongyuan Ma and colleagues for The Vascular Niche Regulates Hematopoietic Stem and Progenitor Cell Lodgment and Expansion via klf6a-ccl25b Cell Developmental Cell 42:4, 349-362 doi:10.1016/j.devcel.2017.07.012
Sean J. Morrison and colleagues for Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF Nature Cell Biology 19, 891–903 (2017) doi:10.1038/ncb3570
Isabel Beerman, Francois E. Mercier, David T. Scadden, and colleagues for ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells Blood 2017 130:619-624; doi: 10.1182/blood-2016-09-738591
Benjamin L. Ebert and colleague for Prevalent premalignancy Blood 2017 130:695-696; doi: 10.1182/blood-2017-05-786210
Click here to read more on the ISEH website
International Society for Experimental Hematology 330 North Wabash Avenue, Suite 2000, Chicago, IL 60611, USA Ph: +1 (312) 321.5114 Fax: +1 (312) 673.6923 E-mail: [email protected] Visit www.iseh.org