June 2, 2020 u vol. 117 u no. 22

From the Cover

12306 Integrins and T cell motility 11975 Growth of tropical cyclone intensity 12017 Strengthening cereal plant defenses against pests 12269 Activin-A and neuroinflammation 12472 Convergent evolution of biosynthetic gene clusters

Contents

THIS WEEK IN PNAS Cover image: Pictured is an extended 11845 In This Issue focus view of a human trachea showing epithelial cells (blue), CD8 T cells (green), and the proteins CD49a (red) INNER WORKINGS—An over-the-shoulder look at scientists at work and CD103 (cyan). Blood vessels (red) 11847 Technique to study poop offers a snapshot of diets, ecosystems, and climate and elastin fibrils (green) also appear Amy McDermott within the tissue parenchyma. Emma C. Reilly et al. identified how receptors on COMMENTARIES the surface of tissue-resident memory T 11850 Oocyte aneuploidy—more tools to tackle an old problem (TRM) cells, which remain in peripheral tissues after infection clearance, affect Chris Lodge and Mary Herbert the cells’ motility and ability to interact See companion article on page 10455 in issue 19 of volume 117 with peripheral tissues, contributing to 11853 A new pathway of macrophage cholesterol efflux TRM persistence and long-term Marit Westerterp and Alan R. Tall immunity. The results could help See companion article on page 10476 in issue 19 of volume 117 develop T -inducing influenza vaccines RM 11856 Climate change and the aridification of North America that can protect against a breadth of Jonathan T. Overpeck and Bradley Udall virus strains. See the article by Reilly See companion article on page 11328 in issue 21 of volume 117 et al. on pages 12306–12314. Image credit: Emma C. Reilly and LETTERS David J. Topham. 11859 Do puffins use tools? Alice M. I. Auersperg, Raoul Schwing, Berenika Mioduszewska, Mark O’Hara, and Ludwig Huber 11860 Reply to Auersperg et al.: Puffin tool use is no fluke Annette L. Fayet, Erpur Snær Hansen, and Dora Biro 11862 Simplified model assumptions artificially constrain the parameter range in which selection at the holobiont level can occur Itay Daybog and Oren Kolodny 11864 Reply to Daybog and Kolodny: Necessary requirements for holobiont-level selection are robust to model assumptions Simon van Vliet and Michael Doebeli INAUGURAL ARTICLE 11865 The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms Rau´l Padro´n, Weikang Ma, Sebastian Duno-Miranda, Natalia Koubassova, Kyoung Hwan Lee, Antonio Pinto, Lorenzo Alamo, Pura Bolan˜os, Andrey Tsaturyan, Thomas Irving, and Roger Craig

Free online through the PNAS open access option. PNAS u June 2, 2020 u vol. 117 u no. 22 u iii–viii Downloaded by guest on September 28, 2021 BRIEF REPORT 11947 Origin of transparency in scattering biomimetic collagen materials 11875 The airborne lifetime of small speech droplets Chrystelle Salameh, Flore Salviat, Elora Bessot, Mile´na Lama, and their potential importance in SARS- Jean-Marie Chassot, Elodie Moulongui, Yan Wang, Marc CoV-2 transmission Robin, Arnaud Bardouil, Mohamed Selmane, Franck Artzner, Valentyn Stadnytskyi, Christina E. Bax, Adriaan Bax, Alba Marcellan, Cle´ment Sanchez, Marie-Madeleine and Philip Anfinrud Giraud-Guille, Marco Faustini, Re´mi Carminati, and Nadine Nassif 12041 Live-cell protein engineering with an ultra-short PHYSICAL SCIENCES split intein Antony J. Burton, Michael Haugbro, Eva Parisi, APPLIED PHYSICAL SCIENCES and Tom W. Muir 11878 Rational design principles for giant spin Hall effect in 12080 Light-controlled twister ribozyme with single- 5d-transition metal oxides molecule detection resolves RNA function Priyamvada Jadaun, Leonard F. Register, and Sanjay K. Banerjee in time and space Arthur Korman, Huabing Sun, Boyang Hua, Haozhe Yang, 11887 Scaling of relaxation and excess entropy in plastically Joseph N. Capilato, Rakesh Paul, Subrata Panja, Taekjip Ha, deformed amorphous solids Marc M. Greenberg, and Sarah A. Woodson K. Lawrence Galloway, Xiaoguang Ma, Nathan C. 12087 Kinetic diversity of amyloid oligomers Keim, Douglas J. Jerolmack, Arjun G. Yodh, and Paulo E. Arratia Alexander J. Dear, Thomas C. T. Michaels, Georg Meisl, David Klenerman, Si Wu (吴思), Sarah Perrett, Sara Linse, 11894 Cooperatively enhanced reactivity and “stabilitaxis” Christopher M. Dobson, and Tuomas P. J. Knowles of dissociating oligomeric proteins 12109 Contact-ID, a tool for profiling organelle Jaime Agudo-Canalejo, Pierre Illien, and Ramin Golestanian contact sites, reveals regulatory 11901 Oscillating collective motion of active rotors proteins of mitochondrial-associated in confinement membrane formation Peng Liu, Hongwei Zhu, Ying Zeng, Guangle Du, Luhui Ning, Chulhwan Kwak, Sanghee Shin, Jong-Seok Park, Minkyo Jung, Dunyou Wang, Ke Chen, Ying Lu, Ning Zheng, Fangfu Ye, Truong Thi My Nhung, Myeong-Gyun Kang, Chaiheon Lee, and Mingcheng Yang Tae-Hyuk Kwon, Sang Ki Park, Ji Young Mun, Jong-Seo Kim, 12029 Evaluation of musculoskeletal phenotype of the and Hyun-Woo Rhee G608G progeria mouse model with lonafarnib, pravastatin, and zoledronic acid as treatment groups COMPUTER SCIENCES Maria B. Cubria, Sebastian Suarez, Aidin Masoudi, Ramin 12402 Habituation as a neural algorithm for online Oftadeh, Pramod Kamalapathy, Amanda DuBose, Michael R. odor discrimination Erdos, Wayne A. Cabral, Lamya Karim, Francis S. Collins, Yang Shen, Sanjoy Dasgupta, and Saket Navlakha Brian D. Snyder, and Ara Nazarian

EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES BIOPHYSICS AND COMPUTATIONAL BIOLOGY 11908 Functional stability of water wire–carbonyl 11954 Global reconstruction reduces the uncertainty of interactions in an ion channel oceanic nitrous oxide emissions and reveals a vigorous seasonal cycle Joana Paulino, Myunggi Yi, Ivan Hung, Zhehong Gan, Xiaoling Wang, Eduard Y. Chekmenev, Huan-Xiang Zhou, Simon Yang, Bonnie X. Chang, Mark J. Warner, Thomas S. and Timothy A. Cross Weber, Annie M. Bourbonnais, Alyson E. Santoro, Annette Kock, Rolf E. Sonnerup, John L. Bullister, Samuel T. Wilson, and Daniele Bianchi CHEMISTRY 11961 Ediacaran reorganization of the marine 11916 Kinetic analysis of amino acid radicals formed in phosphorus cycle I H2O2-driven Cu LPMO reoxidation implicates Thomas A. Laakso, Erik A. Sperling, David T. Johnston, dominant homolytic reactivity and Andrew H. Knoll Stephen M. Jones, Wesley J. Transue, Katlyn K. Meier, Bradley 11968 Thermogenic carbon release from the Central Kelemen, and Edward I. Solomon Atlantic magmatic province caused major end- 11923 Fluorescent Janus emulsions for biosensing of Triassic carbon cycle perturbations Listeria monocytogenes Thea H. Heimdal, Morgan T. Jones, and Henrik. H. Svensen Jie Li, Suchol Savagatrup, Zachary Nelson, Kosuke Yoshinaga, 11975 Global increase in major tropical cyclone exceedance and Timothy M. Swager probability over the past four decades 11931 Nanovesicles displaying functional linear and James P. Kossin, Kenneth R. Knapp, Timothy L. Olander, branched oligomannose self-assembled from and Christopher S. Velden sequence-defined Janus glycodendrimers 11981 In situ X-ray diffraction of silicate liquids and glasses Qi Xiao, Martina Delbianco, Samuel E. Sherman, under dynamic and static compression to Aracelee M. Reveron Perez, Priya Bharate, Alonso megabar pressures Pardo-Vargas, Cesar Rodriguez-Emmenegger, Nina Yu Kostina, Khosrow Rahimi, Dominik So¨der, Guillaume Morard, Jean-Alexis Hernandez, Marco Martin Mo¨ller, Michael L. Klein, Peter H. Seeberger, Guarguaglini, Riccardo Bolis, Alessandra Benuzzi-Mounaix, and Virgil Percec Tommaso Vinci, Guillaume Fiquet, Marzena A. Baron, Sang Heon Shim, Byeongkwan Ko, Arianna E. Gleason, Wendy L. 11940 Atomic fluctuations in electronic materials revealed Mao, Roberto Alonso-Mori, Hae Ja Lee, Bob Nagler, Eric by dephasing Galtier, Dimosthenis Sokaras, Siegfried H. Glenzer, Denis Samuel Palato, He´le`ne Seiler, Parmeet Nijjar, Oleg Prezhdo, Andrault, Gaston Garbarino, Mohamed Mezouar, Anja K. and Patanjali Kambhampati Schuster, and Alessandra Ravasio

iv u www.pnas.org Contents Downloaded by guest on September 28, 2021 ENGINEERING BIOCHEMISTRY 11987 Development of a long-acting direct-acting antiviral 11916 Kinetic analysis of amino acid radicals formed in I system for hepatitis C virus treatment in swine H2O2-driven Cu LPMO reoxidation implicates Malvika Verma, Jacqueline N. Chu, John A. F. Salama, dominant homolytic reactivity Mohammed T. Faiz, Feyisope Eweje, Declan Gwynne, Aaron Stephen M. Jones, Wesley J. Transue, Katlyn K. Meier, Bradley Lopes, Kaitlyn Hess, Vance Soares, Christoph Steiger, Rebecca Kelemen, and Edward I. Solomon McManus, Ryan Koeppen, Tiffany Hua, Alison Hayward, Joy Collins, Siddartha M. Tamang, Keiko Ishida, Jonathan B. Miller, 11954 Global reconstruction reduces the uncertainty of Stephanie Katz, Alexander H. Slocum, Mark S. Sulkowski, oceanic nitrous oxide emissions and reveals David L. Thomas, Robert Langer, and Giovanni Traverso a vigorous seasonal cycle Simon Yang, Bonnie X. Chang, Mark J. Warner, Thomas S. 12486 Spike-induced ordering: Stochastic neural spikes Weber, Annie M. Bourbonnais, Alyson E. Santoro, Annette provide immediate adaptability to the Kock, Rolf E. Sonnerup, John L. Bullister, Samuel T. Wilson, sensorimotor system and Daniele Bianchi Shogo Yonekura and Yasuo Kuniyoshi 12041 Live-cell protein engineering with an ultra-short STATISTICS split intein 11995 An objective Bayesian analysis of life’s early start and Antony J. Burton, Michael Haugbro, Eva Parisi, and Tom W. Muir our late arrival – David Kipping 12050 Liquid liquid phase separation of type II diabetes- associated IAPP initiates hydrogelation 12004 Catalytic prior distributions with application to and aggregation generalized linear models Lior Pytowski, Chiu Fan Lee, Alex C. Foley, David J. Vaux, Dongming Huang, Nathan Stein, Donald B. Rubin, and Le´titia Jean and S. C. Kou 12062 Two auxiliary factors promote Dmc1-driven DNA strand exchange via stepwise mechanisms SOCIAL SCIENCES Hideo Tsubouchi, Bilge Argunhan, Kentaro Ito, Masayuki Takahashi, and Hiroshi Iwasaki ECONOMIC SCIENCES 12071 Physiological levels of folic acid reveal purine 12011 NIH funding and the pursuit of edge science Mikko Packalen and Jay Bhattacharya alterations in Lesch-Nyhan disease Jose´M.Lo´pez, Esther L. Outtrim, Rong Fu, Diane J. Sutcliffe, PSYCHOLOGICAL AND COGNITIVE SCIENCES Rosa J. Torres, and H. A. Jinnah 12411 Cognitive and brain development is independently influenced by socioeconomic status and polygenic BIOPHYSICS AND COMPUTATIONAL BIOLOGY scores for educational attainment 11908 Functional stability of water wire–carbonyl Nicholas Judd, Bruno Sauce, John Wiedenhoeft, Jeshua interactions in an ion channel Tromp, Bader Chaarani, Alexander Schliep, Betteke van Noort, Joana Paulino, Myunggi Yi, Ivan Hung, Zhehong Gan, Xiaoling Jani Penttila¨, Yvonne Grimmer, Corinna Insensee, Andreas Wang, Eduard Y. Chekmenev, Huan-Xiang Zhou, Becker, Tobias Banaschewski, Arun L. W. Bokde, Erin Burke and Timothy A. Cross Quinlan, Sylvane Desrivie`res, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc 12080 Light-controlled twister ribozyme with single- Martinot, Marie-Laure Paille`re Martinot, Eric Artiges, Frauke molecule detection resolves RNA function Nees, Dimitri Papadopoulos Orfanos, Toma´s Paus, Luise in time and space Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Fro¨hner, Arthur Korman, Huabing Sun, Boyang Hua, Haozhe Yang, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Joseph N. Capilato, Rakesh Paul, Subrata Panja, Taekjip Ha, Schumann, Hugh Garavan, and Torkel Klingberg Marc M. Greenberg, and Sarah A. Woodson 12419 Patterns of sociocognitive stratification and perinatal 12087 Kinetic diversity of amyloid oligomers risk in the child brain Alexander J. Dear, Thomas C. T. Michaels, Georg Meisl, David Dag Alnæs, Tobias Kaufmann, Andre F. Marquand, Klenerman, Si Wu (吴思), Sarah Perrett, Sara Linse, Stephen M. Smith, and Lars T. Westlye Christopher M. Dobson, and Tuomas P. J. Knowles 12095 Kinetics of pHLIP peptide insertion into and exit from BIOLOGICAL SCIENCES a membrane Gregory Slaybaugh, Dhammika Weerakkody, Donald M. AGRICULTURAL SCIENCES Engelman, Oleg A. Andreev, and Yana K. Reshetnyak 12017 Induction of defense in cereals by 4- 12101 Multivalent assembly of KRAS with the RAS-binding fluorophenoxyacetic acid suppresses insect pest and cysteine-rich domains of CRAF on the membrane populations and increases crop yields in the field Zhenhao Fang, Ki-Young Lee, Ku-Geng Huo, Genevie`ve Wanwan Wang, Pengyong Zhou, Xiaochang Mo, Lingfei Hu, Gasmi-Seabrook, Le Zheng, Nadeem Moghal, Ming-Sound Nuo Jin, Xia Chen, Zhuoxian Yu, Jinpeng Meng, Matthias Erb, Tsao, Mitsuhiko Ikura, and Christopher B. Marshall Zhicai Shang, Angharad M. R. Gatehouse, Jun Wu, and Yonggen Lou CELL BIOLOGY APPLIED BIOLOGICAL SCIENCES 12109 Contact-ID, a tool for profiling organelle 12029 Evaluation of musculoskeletal phenotype of the contact sites, reveals regulatory G608G progeria mouse model with lonafarnib, proteins of mitochondrial-associated pravastatin, and zoledronic acid as treatment groups membrane formation Maria B. Cubria, Sebastian Suarez, Aidin Masoudi, Ramin Chulhwan Kwak, Sanghee Shin, Jong-Seok Park, Minkyo Jung, Oftadeh, Pramod Kamalapathy, Amanda DuBose, Michael R. Truong Thi My Nhung, Myeong-Gyun Kang, Chaiheon Lee, Erdos, Wayne A. Cabral, Lamya Karim, Francis S. Collins, Tae-Hyuk Kwon, Sang Ki Park, Ji Young Mun, Jong-Seo Kim, Brian D. Snyder, and Ara Nazarian and Hyun-Woo Rhee

Contents PNAS u June 2, 2020 u vol. 117 u no. 22 u v Downloaded by guest on September 28, 2021 12121 Analysis of RAS protein interactions in living cells EVOLUTION reveals a mechanism for pan-RAS depletion by 11961 Ediacaran reorganization of the marine membrane-targeted RAS binders phosphorus cycle Yao-Cheng Li (李燿成), Nikki K. Lytle, Seth T. Gammon, Luke Thomas A. Laakso, Erik A. Sperling, David T. Johnston, Wang, Tikvah K. Hayes, Margie N. Sutton, Robert C. Bast Jr, and Andrew H. Knoll Channing J. Der, David Piwnica-Worms, Frank McCormick, ’ and Geoffrey M. Wahl 11995 An objective Bayesian analysis of life s early start and our late arrival α 12131 Topoisomerase II is essential for maintenance of David Kipping mitotic chromosome structure Christian F. Nielsen, Tao Zhang, Marin Barisic, Paul Kalitsis, 12222 A near full-length HIV-1 genome from 1966 and Damien F. Hudson recovered from formalin-fixed paraffin- embedded tissue 12143 Split-TurboID enables contact-dependent proximity Sophie Gryseels, Thomas D. Watts, Jean-Marie Kabongo labeling in cells Mpolesha, Brendan B. Larsen, Philippe Lemey, Kelvin F. Cho, Tess C. Branon, Sanjana Rajeev, Tanya Svinkina, Jean-Jacques Muyembe-Tamfum, Dirk E. Teuwen, Namrata D. Udeshi, Themis Thoudam, Chulhwan Kwak, and Michael Worobey Hyun-Woo Rhee, In-Kyu Lee, Steven A. Carr, and Alice Y. Ting 12230 Tibetan PHD2, an allele with loss-of- 12155 Kinetochore protein Spindly controls microtubule function properties polarity in Drosophila axons Daisheng Song, Bradleigh E. Navalsky, Wei Guan, Urko del Castillo, Hans-Arno J. Mu¨ller, and Vladimir I. Gelfand Cassandra Ingersoll, Tao Wang, Emanuele Loro, 12164 Ancient MAPK ERK7 is regulated by an unusual Lydia Eeles, Kyle B. Matchett, Melanie J. Percy, John inhibitory scaffold required for Toxoplasma Walsby-Tickle, James S. O. McCullagh, Reinhold J. Medina, apical complex biogenesis Tejvir S. Khurana, Abigail W. Bigham, Terence R. Lappin, and Frank S. Lee Peter S. Back, William J. O’Shaughnessy, Andy S. Moon, Pravin S. Dewangan, Xiaoyu Hu, Jihui Sha, James A. Wohlschlegel, Peter J. Bradley, and Michael L. Reese GENETICS β DEVELOPMENTAL BIOLOGY 12239 -Oxidation and autophagy are critical energy providers during acute glucose depletion in 12174 foxl3, a sexual switch in germ cells, initiates two Saccharomyces cerevisiae independent molecular pathways for commitment Carmen A. Weber, Karthik Sekar, Jeffrey H. Tang, Philipp to oogenesis in medaka Warmer, Uwe Sauer, and Karsten Weis Mariko Kikuchi, Toshiya Nishimura, Satoshi Ishishita, Yoichi Matsuda, and Minoru Tanaka 12249 Viral infection impacts transposable element transcript amounts in Drosophila 12182 Redundant and additive functions of the four Lef/Tcf Marle`ne Roy, Barbara Viginier, E´douard Saint-Michel, transcription factors in lung epithelial progenitors Fre´de´rick Arnaud, Maxime Ratinier, and Marie Fablet Kamryn N. Gerner-Mauro, Haruhiko Akiyama, and Jichao Chen

ECOLOGY IMMUNOLOGY AND INFLAMMATION 12192 Late-spring frost risk between 1959 and 2017 12258 Epigenetic conversion of conventional T cells decreased in North America but increased into regulatory T cells by CD28 signal in Europe and Asia deprivation Constantin M. Zohner, Lidong Mo, Susanne S. Renner, Norihisa Mikami, Ryoji Kawakami, Kelvin Y. Chen, Jens-Christian Svenning, Yann Vitasse, Blas M. Benito, Atsushi Sugimoto, Naganari Ohkura, Alejandro Ordonez, Frederik Baumgarten, Jean-Franc¸ois and Shimon Sakaguchi Bastin, Veronica Sebald, Peter B. Reich, Jingjing Liang, 12269 Activin-A limits Th17 pathogenicity and autoimmune Gert-Jan Nabuurs, Sergio de-Miguel, Giorgio Alberti, neuroinflammation via CD39 and CD73 Clara Anto´n-Ferna´ndez, Radomir Balazy, Urs-Beat Bra¨ndli, ectonucleotidases and Hif1-α–dependent pathways Han Y. H. Chen, Chelsea Chisholm, Emil Cienciala, Selvadurai Ioannis Morianos, Aikaterini I. Trochoutsou, Gina Dayanandan, Tom M. Fayle, Lorenzo Frizzera, Damiano Gianelle, Papadopoulou, Maria Semitekolou, Aggelos Banos, Dimitris Andrzej M. Jagodzinski, Bogdan Jaroszewicz, Tommaso Jucker, Konstantopoulos, Antigoni Manousopoulou, Maria Kapasa, Sebastian Kepfer-Rojas, Mohammed Latif Khan, Hyun Seok Kim, Ping Wei, Brett Lomenick, Elise Belaidi, Themis Kalamatas, Henn Korjus, Vivian Kvist Johannsen, Diana Laarmann, Mait Klinta Karageorgiou, Triantafyllos Doskas, Federica Sallusto, Lang, Tomasz Zawila-Niedzwiecki, Pascal A. Niklaus, Alain Fan Pan, Spiros D. Garbis, Francisco J. Quintana, Paquette, Hans Pretzsch, Purabi Saikia, Peter Schall, Vladimı´r  and Georgina Xanthou Seben, Miroslav Svoboda, Elena Tikhonova, Helder Viana, Chunyu Zhang, Xiuhai Zhao, and Thomas W. Crowther 12281 CXCL5-mediated recruitment of neutrophils into the 12201 Characterizing long-range search behavior in Diptera peritoneal cavity of Gdf15-deficient mice protects using complex 3D virtual environments against abdominal sepsis Pavan Kumar Kaushik, Marian Renz, and Shannon B. Olsson Isa Santos, Henrique G. Colac¸o, Ana Neves-Costa, Elsa Seixas, Tiago R. Velho, Dora Pedroso, Andre´ Barros, Rui Martins, 12208 Specialized meltwater biodiversity persists despite Nuno Carvalho, Didier Payen, Sebastian Weis, Hyon-Seung Yi, widespread deglaciation Minho Shong, and Luı´s F. Moita Clint C. Muhlfeld, Timothy J. Cline, J. Joseph Giersch, 12288 Polygenic risk for skin autoimmunity impacts immune Erich Peitzsch, Caitlyn Florentine, Dean Jacobsen, and Scott Hotaling checkpoint blockade in bladder cancer Zia Khan, Flavia Di Nucci, Antonia Kwan, Christian Hammer, 12215 Dynamics and functional diversity of the smallest Sanjeev Mariathasan, Vincent Rouilly, Jonathan Carroll, phytoplankton on the Northeast US Shelf Magnus Fontes, Sergio Ley Acosta, Ellie Guardino, Haiyin Bethany L. Fowler, Michael G. Neubert, Kristen R. Chen-Harris, Tushar Bhangale, Ira Mellman, Jonathan Hunter-Cevera, Robert J. Olson, Alexi Shalapyonok, Andrew R. Rosenberg, Thomas Powles, Julie Hunkapiller, G. Scott Solow, and Heidi M. Sosik Chandler, and Matthew L. Albert

vi u www.pnas.org Contents Downloaded by guest on September 28, 2021 + 12295 Marginal zone SIGN-R1 macrophages are essential 12387 L-Arginine sensing regulates virulence gene for the maturation of germinal center B cells in expression and disease progression in the spleen enteric pathogens Gabriela Pirgova, Anne Chauveau, Andrew J. MacLean, Zelia Menezes-Garcia, Aman Kumar, Wenhan Zhu, Sebastian E. Jason G. Cyster, and Tal I. Arnon Winter, and Vanessa Sperandio

12306 TRM integrins CD103 and CD49a differentially 12394 Host nutrient milieu drives an essential role for support adherence and motility after resolution aspartate biosynthesis during invasive of influenza virus infection Staphylococcus aureus infection Emma C. Reilly, Kris Lambert Emo, Patrick M. Buckley, Aimee D. Potter, Casey E. Butrico, Caleb A. Ford, Jacob M. Nicholas S. Reilly, Ian Smith, Francisco A. Chaves, Hongmei Curry, Irina A. Trenary, Srivarun S. Tummarakota, Andrew S. Yang, Patrick W. Oakes, and David J. Topham Hendrix, Jamey D. Young, and James E. Cassat

MEDICAL SCIENCES NEUROSCIENCE 12315 Transcriptional profiling identifies an androgen 12402 Habituation as a neural algorithm for online receptor activity-low, stemness program associated odor discrimination with enzalutamide resistance Yang Shen, Sanjoy Dasgupta, and Saket Navlakha Joshi J. Alumkal, Duanchen Sun, Eric Lu, Tomasz M. Beer, 12411 Cognitive and brain development is independently George V. Thomas, Emile Latour, Rahul Aggarwal, Jeremy influenced by socioeconomic status and polygenic Cetnar, Charles J. Ryan, Shaadi Tabatabaei, Shawna Bailey, scores for educational attainment Claire B. Turina, David A. Quigley, Xiangnan Guan, Adam Nicholas Judd, Bruno Sauce, John Wiedenhoeft, Jeshua Foye, Jack F. Youngren, Joshua Urrutia, Jiaoti Huang, Alana S. Tromp, Bader Chaarani, Alexander Schliep, Betteke van Noort, Weinstein, Verena Friedl, Matthew Rettig, Robert E. Reiter, Jani Penttila¨, Yvonne Grimmer, Corinna Insensee, Andreas Daniel E. Spratt, Martin Gleave, Christopher P. Evans, Becker, Tobias Banaschewski, Arun L. W. Bokde, Erin Burke Joshua M. Stuart, Yiyi Chen, Felix Y. Feng, Eric J. Small, Quinlan, Sylvane Desrivie`res, Herta Flor, Antoine Grigis, Owen N. Witte, and Zheng Xia Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc 12324 Lumefantrine, an antimalarial drug, reverses Martinot, Marie-Laure Paille`re Martinot, Eric Artiges, Frauke radiation and temozolomide resistance Nees, Dimitri Papadopoulos Orfanos, Toma´s Paus, Luise in glioblastoma Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Fro¨hner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Yetirajam Rajesh, Angana Biswas, Utkarsh Kumar, Indranil Schumann, Hugh Garavan, and Torkel Klingberg Banerjee, Subhayan Das, Santanu Maji, Swadesh K. Das, Luni Emdad, Webster K. Cavenee, Mahitosh Mandal, 12419 Patterns of sociocognitive stratification and perinatal and Paul B. Fisher risk in the child brain 12332 Combined loss of function of two different loci of Dag Alnæs, Tobias Kaufmann, Andre F. Marquand, miR-15/16 drives the pathogenesis of acute Stephen M. Smith, and Lars T. Westlye myeloid leukemia 12428 Absence of Sac2/INPP5F enhances the phenotype of Francesca Lovat, Giovanni Nigita, Rosario Distefano, Tatsuya a Parkinson’s disease mutation of synaptojanin 1 Nakamura, Pierluigi Gasparini, Luisa Tomasello, Paolo Fadda, Mian Cao, Daehun Park, Yumei Wu, and Pietro De Camilli Narmin Ibrahimova, Silvia Catricala`, Alexey Palamarchuk, Michael A. Caligiuri, Anna Gallı`, Luca Malcovati, Mark D. PHARMACOLOGY Minden, and Carlo M. Croce 12435 The β-arrestin-biased β-adrenergic receptor blocker 12341 KLF7 promotes pancreatic cancer growth and carvedilol enhances skeletal muscle contractility metastasis by up-regulating ISG expression Jihee Kim, Chad A. Grotegut, James W. Wisler, Lan and maintaining Golgi complex integrity Mao, Paul B. Rosenberg, Howard A. Rockman, Romi Gupta, Parmanand Malvi, Keshab Raj Parajuli, Radoslav and Robert J. Lefkowitz Janostiak, Suresh Bugide, Guoping Cai, Lihua Julie Zhu, 12444 Evaluation of plant sources for antiinfective lead Michael R. Green, and Narendra Wajapeyee compound discovery by correlating phylogenetic, 12352 Imaging lutein and zeaxanthin in the human retina spatial, and bioactivity data with confocal resonance Raman microscopy Laura Holzmeyer, Anne-Kathrin Hartig, Katrin Franke, Binxing Li, Evan W. George, Gregory T. Rognon, Aruna Wolfgang Brandt, Alexandra N. Muellner-Riehl, Ludger A. Gorusupudi, Arunkumar Ranganathan, Fu-Yen Chang, Linjia Wessjohann, and Jan Schnitzler Shi, Jeanne M. Frederick, and Paul S. Bernstein 12359 Hepsin enhances liver metabolism and inhibits PHYSIOLOGY adipocyte browning in mice 11865 The myosin interacting-heads motif present in live Shuo Li, Jianhao Peng, Hao Wang, Wei Zhang, J. Mark Brown, tarantula muscle explains tetanic and posttetanic Yiqing Zhou, and Qingyu Wu phosphorylation mechanisms Rau´l Padro´n, Weikang Ma, Sebastian Duno-Miranda, Natalia MICROBIOLOGY Koubassova, Kyoung Hwan Lee, Antonio Pinto, Lorenzo 12368 Tenofovir prodrugs potently inhibit Epstein–Barr Alamo, Pura Bolan˜os, Andrey Tsaturyan, Thomas Irving, and Roger Craig virus lytic DNA replication by targeting the viral DNA polymerase PLANT BIOLOGY Natalia C. Drosu, Elazer R. Edelman, and David E. Housman 12452 Chloroplast Sec14-like 1 (CPSFL1) is essential for 12375 Spatial mapping of polymicrobial communities normal chloroplast development and affects reveals a precise biogeography associated carotenoid accumulation in Chlamydomonas with human dental caries Jose´G. Garcı´a-Cerda´n, Eva M. Schmid, Tomomi Takeuchi, Ian Dongyeop Kim, Juan P. Barraza, Rodrigo A. Arthur, Anderson McRae, Kent L. McDonald, Nichakarn Yordduangjun, Hara, Karl Lewis, Yuan Liu, Elizabeth L. Scisci, Evlambia Ahmed M. Hassan, Patricia Grob, C. Shan Xu, Harald F. Hess, Hajishengallis, Marvin Whiteley, and Hyun Koo Daniel A. Fletcher, Eva Nogales, and Krishna K. Niyogi

Contents PNAS u June 2, 2020 u vol. 117 u no. 22 u vii Downloaded by guest on September 28, 2021 12464 Transcriptomic network analyses shed light on the CORRECTIONS regulation of cuticle development in maize leaves Pengfei Qiao, Richard Bourgault, Marc Mohammadi, Susanne SUSTAINABILITY SCIENCE Matschi, Glenn Philippe, Laurie G. Smith, Michael A. Gore, Isabel Molina, and Michael J. Scanlon 12497 Harvesting synergy from sustainable development goal interactions 12472 Genomic evidence for convergent evolution of gene Matteo Pedercini, Steve Arquitt, David Collste, clusters for momilactone biosynthesis in land plants and Hans Herren Lingfeng Mao, Hiroshi Kawaide, Toshiya Higuchi, Meihong Chen, Koji Miyamoto, Yoshiki Hirata, Honoka Kimura, Sho IMMUNOLOGY Miyazaki, Miyu Teruya, Kaoru Fujiwara, Keisuke Tomita, Hisakazu Yamane, Ken-ichiro Hayashi, Hideaki Nojiri, Lei Jia, 12498 Posttranscriptional regulation of interleukin-10 Jie Qiu, Chuyu Ye, Michael P. Timko, Longjiang Fan, expression by hsa-miR-106a and Kazunori Okada Amit Sharma, Manish Kumar, Jyotirmoi Aich, Manoj Hariharan, Samir K. Brahmachari, Anurag Agrawal, SUSTAINABILITY SCIENCE and Balaram Ghosh 12481 New spatial analyses of Australian wildfires highlight the MICROBIOLOGY need for new fire, resource, and conservation policies David B. Lindenmayer and Chris Taylor 12500 Integrative approach using Yersinia pestis genomes to revisit the historical landscape of plague during SYSTEMS BIOLOGY the Medieval Period Amine Namouchi, Meriam Guellil, Oliver Kersten, Stephanie 12486 Spike-induced ordering: Stochastic neural spikes Ha¨nsch, Claudio Ottoni, Boris V. Schmid, Elsa Pacciani, Luisa provide immediate adaptability to the Quaglia, Marco Vermunt, Egil L. Bauer, Michael Derrick, Anne Ø. sensorimotor system Jensen, Sacha Kacki, Samuel K. Cohn Jr., Nils C. Stenseth, Shogo Yonekura and Yasuo Kuniyoshi and Barbara Bramanti

viii u www.pnas.org Contents Downloaded by guest on September 28, 2021