Doxycycline 50Mg and 100Mg Capsules Numbers of Different Cell Types in the Blood

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• Skin that is more sensitive to sunlight than Reporting of side effects normal. You may get a skin rash, itching, redness If you get any side effects, talk to your doctor, or severe sunburn. If this happens, stop taking pharmacist or nurse. This includes any possible side Package leaflet: Information for the user the medicine and tell your doctor. effects not listed in this leaflet. You can also report • Inflammation and/or ulcers of the gullet. side effects directly via the Yellow Card Scheme at: • Blood disorders. These are due to changes in www.mhra.gov.uk/yellowcard or search for MHRA Doxycycline 50mg and 100mg capsules numbers of different cell types in the blood. Yellow Card in the Google Play or Apple App Store. Symptoms may include tiredness, easy bruising By reporting side effects, you can help provide or infections. more information on the safety of this medicine. • Low blood pressure. Read all of this leaflet carefully before you Mountain spotted fever, travellers’ diarrhoea, malaria and leptospirosis (a bacterial infection). • Increased heart rate. 5 How to store Doxycycline capsules start taking this medicine because it contains • Aches in the joints or muscles. important information for you. Your doctor may want you to take Doxycycline Keep out of the sight and reach of children. Store capsules to treat another infection not listed above. • Stomach pain and diarrhoea. below 25ºC in a dry place. • Keep this leaflet. You may need to read it The side effects listed below may go away during You may also be prescribed an additional medicine Do not use Doxycycline capsules after the expiry again. to take with Doxycycline capsules to treat your treatment as your body adjusts to the medicine. date stated on the label/carton/bottle. The expiry • If you have any further questions, ask your Tell your doctor if any of these side effects continue infection. You must talk to your doctor if you do not date refers to the last day of that month. doctor, pharmacist or nurse. feel better or if you feel worse. to bother you: Medicines should not be disposed of via • This medicine has been prescribed for you Common: may affect up to 1 in 10 people wastewater or household waste. Ask your only. Do not pass it on to others. It may harm 2 What you need to know before you • feeling or being sick pharmacist how to dispose of medicines no longer them, even if their signs of illness are the same • worsening of a disease called systemic lupus required. These measures will help to protect the take Doxycycline capsules as yours. Do not take Doxycycline capsules if you: erythematous (SLE). This is an allergic condition environment. • If you get any side effects, talk to your doctor, which causes joint pain, skin rash and fever • are allergic to doxycycline, other similar pharmacist or nurse. This includes any headache 6 Contents of the pack and other antibiotics (such as minocycline or tetracycline) • pericarditis (inflammation affecting the heart) possible side effects not listed in this leaflet. or any of the other ingredients of this medicine information See section 4. (listed in section 6) Uncommon: may affect up to 1 in 100 people • are pregnant or trying to become pregnant • heartburn What Doxycycline capsules contain • The active substance (the ingredient that makes What is in this leaflet • are breast-feeding. • vaginal infection You should not use Doxycycline capsules during the capsule work) is Doxycycline hyclate. Each 1 What Doxycycline capsules are and Rare: may affect up to 1 in 1,000 people capsule contains either 50mg or 100mg of periods of tooth development (pregnancy, infancy • anxiety Doxycycline base. what they are used for or in children below 8 years old) as such use may • difficulty in swallowing, sore or painful tongue • The other ingredients are gelatin, magnesium 2 What you need to know before you lead to permanent discolouration (yellow-grey- or mouth stearate, shellac glaze, sodium lauryl sulfate, take Doxycycline capsules brown). • skin reddening (flushing) starch, quinoline yellow (E104), erythrosine 3 How to take Doxycycline capsules There may be circumstances (e.g. severe or life- • a ringing or buzzing noise in the ear (E127), patent blue V (E131), titanium dioxide threatening conditions), where your physician 4 Possible side effects • soreness and itching of the rectal and/or genital (E171), iron oxide black (E172), and propylene may decide that the benefits outweigh this risk in area glycol. 5 How to store Doxycycline capsules children below 8 years and Doxycycline capsules • inflammation of the bowel What Doxycycline capsules look like and 6 Contents of the pack and other should be prescribed. • bulging fontanelles (soft spot on head) of infants information Warnings and precautions • increased pressure in the skull (severe headache contents of the pack Talk to your doctor or pharmacist before taking with change in vision) Doxycycline 50mg capsules are green and white 1 Doxycycline capsules if any of the following apply • inflammation and damage to the liver hard gelatin capsules printed “C” and “DV” in black. What Doxycycline capsules are and to you: • abnormal liver function tests Doxycycline 100mg capsules are green hard what they are used for • you are likely to be exposed to strong sunlight • discolouration of the thyroid tissue when given gelatin capsules printed “C” and “DW” in black. Doxycycline is an antibiotic belonging to a group or UV light (e.g. on a sun bed). You should avoid for long periods. The medicine does not impair Doxycycline 50mg capsules are available in pack of medicines called tetracyclines. It is used to treat exposure to strong sunlight while taking this thyroid function sizes of 28 capsules. many different types of infections including: medicine as your skin may be more sensitive to • loosening of the nail from the nail bed after Doxycycline 100mg capsules are available in pack • Chest, lung or nasal infections e.g. bronchitis, sunburn than normal. exposure to the sun sizes of 8 & 50 capsules. pneumonia, sinusitis • you have kidney or liver problems. • increased levels of urea in the blood • Urinary tract infections (the passage through Marketing Authorisation Holder and • you have myasthenia gravis (a disease which • yellow skin and eyes (jaundice), inflammation of which urine passes) e.g. cystitis, urethritis Manufacturer causes unusual tiredness and weakness of the pancreas • Acne (a skin condition) Accord Barnstaple, EX32 8NS, UK certain muscles, particularly in the eyelid). • upset stomach, loss of appetite, diarrhoea (this • Eye infections This leaflet was last revised in October 2020 • you have porphyria (a rare disease of blood may occur up to two or three months after the • Sexually transmitted diseases e.g. gonorrhoea, pigments). last dose), stomach pain syphilis, chlamydia If you would like a • you have (or have ever had) systemic lupus • darker patches on your skin. • Fevers associated with louse or tick bites leaflet with larger • Malaria, when chloroquine is not effective erythematosus (an allergic condition that causes Not known: frequency cannot be estimated from text, please contact Doxycycline capsules are also used to prevent joint pain, skin rashes and fever). This condition the available data certain infections developing, these are scrub may be worsened by taking Doxycycline • discolouration and/or lack of growth of teeth 01271 385257. typhus (a disease carried by small insects) Rocky capsules. Continued top of next column 50994082 BBBA9053 Continued top of next column Continued over page

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Doxycycline Capsules 50, 100mg x 8, 28, 56 (UK) Doxycycline hyclate 50mg and 100mg Capsules PIL - UK JDE No.: 50994082 approved for print/date Item number: BBBA9053 Colours Non Printing Colours Dimensions: 296x210 (Reel Fed) 1. Black 1. Profile Originator: M.Doak Dimensions: 296 x 210mm 2. 2. Component: Leaflet for Blisters Origination Date: 25/09/2020 Min Body Text Size: 9pt Revision Date: 22/10/2020 Supplier: Accord Barnstaple 3. 3. Pharmacode: 3792 Revised By: M.Doak 4. 5. Proof Round Date Sent: Technical Date sent: N/A 6. 25/09/20 5 Approval Date received: N/A Technologist: T. Hull [email protected] Technically Approved Cartons and label leaflets only (labels only when specified) German GTIN 14 (incorporating PZN): N/A * Please note that only Artwork Studio is permitted to make changes to the above artwork. Version 7 No changes are permitted by any 3rd party other than added notes and mark ups for required changes. 12.02.2020 • you are suspected of having syphilis. Your Pregnancy and breast-feeding Adults and children aged 12 years to less than If you forget to take Doxycycline capsules doctor will continue to monitor you after your If you are pregnant or breast-feeding, think you 18 years: If you forget to take a capsule, take it as soon as you treatment has stopped. may be pregnant or are planning to have a baby 200mg on the first day, then 100 mg daily. The can. Take your next capsule at the right time. Do • you have diarrhoea or usually get diarrhoea ask your doctor or pharmacist for advice before length of treatment is dependent on the infection not take a double dose to make up for a forgotten when you take antibiotics or have suffered from taking this medicine. being treated. dose. problems with your stomach or intestines. If Doxycycline capsules must not be taken if you are Acne: 50mg daily for 6-12 weeks, with food or a If you stop taking Doxycycline capsules you develop severe or prolonged or bloody pregnant or breast-feeding. drink. If you stop taking the capsules too soon, the diarrhoea during or after using Doxycycline Driving and using machines infection may return. Take the capsules for the full capsules tell your doctor immediately since Sexually Transmitted Diseases: 100mg twice This medicine should not affect your ability to drive time of treatment, even when you begin to feel it may be necessary to interrupt the treatment. daily for 7 - 10 days. or use machines. better. This may be a sign of bowel inflammation Primary and Secondary Syphilis: 200mg twice If you have any further questions on the use of this This medicine contains less than 1 mmol (pseudomembranous colitis) which can occur daily for 2 weeks. Your doctor will continue to medicine, ask your doctor or pharmacist. following treatment with antibiotics. sodium (23 mg) per capsule, that is to say monitor you after your treatment has stopped. • you are taking oral retinoids as there is a higher essentially ‘sodium-free’. Fevers associated with louse or tick bites: single 4 risk of suffering from increased pressure in your Possible side effects dose of 100mg or 200mg depending on severity. Like all medicines, this medicine can cause side skull (severe headache with change in vision) 3 How to take Doxycycline capsules Treatment of malaria, when chloroquine is not effects, although not everybody gets them. when taken with Doxycycline capsules. Always take this medicine exactly as your effective: 200mg daily for at least 7 days. When used for a long duration, Doxycycline doctor has told you. Check with your doctor or Stop taking this medicine and tell your capsules may cause infections that cannot be pharmacist if you are not sure. Prevention of malaria: 100mg daily from 1-2 days doctor immediately if you experience any of before travelling to a malarial area until 4 weeks the following serious side effects after taking treated with this antibiotic. Your doctor can explain Swallow the capsules whole with a full glass after returning. this medicine. Although they are very rare, the the signs and symptoms of such types of infection. of water, if the capsules irritate your stomach symptoms can be severe. take them with food or milk. You should take Prevention of scrub typhus: single dose of Other medicines and Doxycycline capsules • Sudden wheeziness, difficulty in breathing, the capsules either sitting down or standing 200mg. Tell your doctor or pharmacist if you are taking, chest pain, fever, swelling of eyelids, face or lips, up and well before you go to bed for the night, have recently taken or might take any other Prevention of travellers’ diarrhoea: 100mg twice rash or itching (especially affecting the whole to stop irritation and ulceration of your gullet. It medicines (including medicines you have obtained daily on the first day of travel, followed by 100mg body). is important not to lie down for at least thirty without a prescription). daily throughout the stay in the area. If you are • Upset stomach, loss of appetite, severe, minutes after taking Doxycycline capsules. If you are taking any of the medicines listed below planning to take these capsules for more than 21 persistent or bloody diarrhoea (this may occur tell your doctor before taking Doxycycline capsules. The recommended doses are shown in the list days, please consult your doctor. up to two or three months after the last dose Some medicines can reduce the effectiveness of below. These are the different doses that your Prevention of leptospirosis: 200mg once each and may be associated with stomach pain or Doxycycline capsules, these include: doctor may prescribe depending on the infection week during the stay in the area; 200mg on fever). This may occur after treatment with • antacids (indigestion remedies), iron being treated. completion of the trip. If you are planning to take antibiotics and can be a sign of serious bowel preparations, oral zinc or bismuth. Usual Dose (Chest, lung or nasal, urinary tract, these capsules for more than 21 days, please inflammation. These should not be taken at the same time of eye and other infections): consult your doctor. • Fever, swollen lymph nodes or skin rash. These day as Doxycycline capsules. 200mg on the first day, then 100mg daily. The may be symptoms of a condition known as • carbamazepine, phenytoin (medicines used Treatment of Rocky Mountain spotted fever: length of treatment is dependent on the infection DRESS (Drug Reaction with Eosinophilia and to control epilepsy) and barbiturates (used to Adults: 100 mg every 12 hours. being treated. Systemic Symptoms) and can be severe and control epilepsy or as a sedative). Children: weighing less than 45 kg: 2.2 mg/kg body Children aged 8 years to less than 12 years: weight given twice a day. Children weighing 45 kg life-threatening. Doxycycline capsules can affect the action of some Doxycycline for the treatment of acute infections in or more should receive the adult dose. • Very severe headache which may be associated other medicines, these include: children aged 8 years to less than 12 years should Patients should be treated for at least 3 days after with visual disturbances such as blurred vision, • increased action of warfarin or coumarins (used be used in situations where other drugs are not the fever subsides and until there is evidence double vision or loss of vision. Permanent to prevent blood clots) available or are not likely to be effective. In such of clinical improvement. Minimum course of visual loss has been reported. The possible • reduced effectiveness of oral contraceptives circumstances, the usual doses are: treatment is 5-7 days. symptoms in benign intracranial hypertension (birth control pills) include headache, vomiting, visual disturbances You should start to feel better within a few days. If • reduced effectiveness of penicillin antibiotics For children 45 kg or less: including blurred vision, a localized defect in the you have been given Doxycycline capsules for acne (used to treat infections) First day: 4.4 mg for each kg of bodyweight (in visual field bordered by an area of normal vision it may be a few weeks before you start to see an • increased blood levels of ciclosporin (a medicine single or 2 divided doses) then 2.2 mg for each (scotoma), double vision (diplopia), and possible improvement. If your infection gets worse or you used to affect the body’s immune response) kg of bodyweight (in single or 2 divided doses) vision loss, in some cases, even permanent. do not start to feel better within a few days (except If you are going to have a general anaesthetic from the second day. The length of treatment is • Serious illness with widespread severe blistering for acne), or a new infection develops, go back and for an operation or dental surgery you must tell dependent on the infection being treated. of the skin, mouth, eyes and genitals. In more severe infections, up to 4.4 mg for each see your doctor. your anaesthetist or dentist that you are taking If any of the side effects listed below occur, contact kg of bodyweight should be given throughout If you take more Doxycycline capsules than you doxycycline as you may have more side effects. your doctor as soon as possible. treatment. should • The Jarisch-Herxheimer reaction which causes Taking Doxycycline capsules with food, If you take too many Doxycycline capsules, contact For children over 45 kg: fever, chills, headache, muscle pain, and skin drink and alcohol your doctor or nearest hospital immediately. Dose administered for adults should be used; rash that is usually self-limiting. This occurs Please see section 3 How to take Doxycycline Always take the labelled medicine package with 200mg on the first day, then 100 mg daily. The shortly after starting doxycycline treatment for capsules. you, whether there are any Doxycycline capsules length of treatment is dependent on the infection infections with spirochete such as Lyme disease. Alcohol may reduce the effect of Doxycycline left or not. capsules and should be avoided. being treated.

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Doxycycline Capsules 50, 100mg x 8, 28, 56 (UK) Doxycycline hyclate 50mg and 100mg Capsules PIL - UK JDE No.: 50994082 approved for print/date Item number: BBBA9053 Colours Non Printing Colours Dimensions: 296x210 (Reel Fed) 1. Black 1. Profile Originator: M.Doak Dimensions: 296 x 210mm 2. 2. Component: Leaflet for Blisters Origination Date: 25/09/2020 Min Body Text Size: 9pt Revision Date: 22/10/2020 Supplier: Accord Barnstaple 3. 3. Pharmacode: 3792 Revised By: M.Doak 4. 5. Proof Round Date Sent: Technical Date sent: N/A 6. 25/09/20 5 Approval Date received: N/A Technologist: T. Hull [email protected] Technically Approved Cartons and label leaflets only (labels only when specified) German GTIN 14 (incorporating PZN): N/A * Please note that only Artwork Studio is permitted to make changes to the above artwork. Version 7 No changes are permitted by any 3rd party other than added notes and mark ups for required changes. 12.02.2020 • Skin that is more sensitive to sunlight than Reporting of side effects normal. You may get a skin rash, itching, redness If you get any side effects, talk to your doctor, or severe sunburn. If this happens, stop taking pharmacist or nurse. This includes any possible side Package leaflet: Information for the user the medicine and tell your doctor. effects not listed in this leaflet. You can also report • Inflammation and/or ulcers of the gullet. side effects directly via the Yellow Card Scheme at: • Blood disorders. These are due to changes in www.mhra.gov.uk/yellowcard or search for MHRA Doxycycline 50mg and 100mg capsules numbers of different cell types in the blood. Yellow Card in the Google Play or Apple App Store. Symptoms may include tiredness, easy bruising By reporting side effects, you can help provide or infections. more information on the safety of this medicine. • Low blood pressure. Read all of this leaflet carefully before you Mountain spotted fever, travellers’ diarrhoea, malaria and leptospirosis (a bacterial infection). • Increased heart rate. 5 How to store Doxycycline capsules start taking this medicine because it contains • Aches in the joints or muscles. important information for you. Your doctor may want you to take Doxycycline Keep out of the sight and reach of children. Store capsules to treat another infection not listed above. • Stomach pain and diarrhoea. below 25ºC in a dry place. • Keep this leaflet. You may need to read it The side effects listed below may go away during You may also be prescribed an additional medicine Do not use Doxycycline capsules after the expiry again. to take with Doxycycline capsules to treat your treatment as your body adjusts to the medicine. date stated on the label/carton/bottle. The expiry • If you have any further questions, ask your Tell your doctor if any of these side effects continue infection. You must talk to your doctor if you do not date refers to the last day of that month. doctor, pharmacist or nurse. feel better or if you feel worse. to bother you: Medicines should not be disposed of via • This medicine has been prescribed for you Common: may affect up to 1 in 10 people wastewater or household waste. Ask your only. Do not pass it on to others. It may harm 2 What you need to know before you • feeling or being sick pharmacist how to dispose of medicines no longer them, even if their signs of illness are the same • worsening of a disease called systemic lupus required. These measures will help to protect the take Doxycycline capsules as yours. Do not take Doxycycline capsules if you: erythematous (SLE). This is an allergic condition environment. • If you get any side effects, talk to your doctor, which causes joint pain, skin rash and fever • are allergic to doxycycline, other similar pharmacist or nurse. This includes any headache 6 Contents of the pack and other antibiotics (such as minocycline or tetracycline) • pericarditis (inflammation affecting the heart) possible side effects not listed in this leaflet. or any of the other ingredients of this medicine information See section 4. (listed in section 6) Uncommon: may affect up to 1 in 100 people • are pregnant or trying to become pregnant • heartburn What Doxycycline capsules contain • The active substance (the ingredient that makes What is in this leaflet • are breast-feeding. • vaginal infection You should not use Doxycycline capsules during the capsule work) is Doxycycline hyclate. Each 1 What Doxycycline capsules are and Rare: may affect up to 1 in 1,000 people capsule contains either 50mg or 100mg of periods of tooth development (pregnancy, infancy • anxiety Doxycycline base. what they are used for or in children below 8 years old) as such use may • difficulty in swallowing, sore or painful tongue • The other ingredients are gelatin, magnesium 2 What you need to know before you lead to permanent discolouration (yellow-grey- or mouth stearate, shellac glaze, sodium lauryl sulfate, take Doxycycline capsules brown). • skin reddening (flushing) starch, quinoline yellow (E104), erythrosine 3 How to take Doxycycline capsules There may be circumstances (e.g. severe or life- • a ringing or buzzing noise in the ear (E127), patent blue V (E131), titanium dioxide threatening conditions), where your physician 4 Possible side effects • soreness and itching of the rectal and/or genital (E171), iron oxide black (E172), and propylene may decide that the benefits outweigh this risk in area glycol. 5 How to store Doxycycline capsules children below 8 years and Doxycycline capsules • inflammation of the bowel What Doxycycline capsules look like and 6 Contents of the pack and other should be prescribed. • bulging fontanelles (soft spot on head) of infants information Warnings and precautions • increased pressure in the skull (severe headache contents of the pack Talk to your doctor or pharmacist before taking with change in vision) Doxycycline 50mg capsules are green and white 1 Doxycycline capsules if any of the following apply • inflammation and damage to the liver hard gelatin capsules printed “C” and “DV” in black. What Doxycycline capsules are and to you: • abnormal liver function tests Doxycycline 100mg capsules are green hard what they are used for • you are likely to be exposed to strong sunlight • discolouration of the thyroid tissue when given gelatin capsules printed “C” and “DW” in black. Doxycycline is an antibiotic belonging to a group or UV light (e.g. on a sun bed). You should avoid for long periods. The medicine does not impair Doxycycline 50mg capsules are available in pack of medicines called tetracyclines. It is used to treat exposure to strong sunlight while taking this thyroid function sizes of 28 capsules. many different types of infections including: medicine as your skin may be more sensitive to • loosening of the nail from the nail bed after Doxycycline 100mg capsules are available in pack • Chest, lung or nasal infections e.g. bronchitis, sunburn than normal. exposure to the sun sizes of 8 & 50 capsules. pneumonia, sinusitis • you have kidney or liver problems. • increased levels of urea in the blood • Urinary tract infections (the passage through Marketing Authorisation Holder and • you have myasthenia gravis (a disease which • yellow skin and eyes (jaundice), inflammation of which urine passes) e.g. cystitis, urethritis Manufacturer causes unusual tiredness and weakness of the pancreas • Acne (a skin condition) Accord Barnstaple, EX32 8NS, UK certain muscles, particularly in the eyelid). • upset stomach, loss of appetite, diarrhoea (this • Eye infections This leaflet was last revised in October 2020 • you have porphyria (a rare disease of blood may occur up to two or three months after the • Sexually transmitted diseases e.g. gonorrhoea, pigments). last dose), stomach pain syphilis, chlamydia If you would like a • you have (or have ever had) systemic lupus • darker patches on your skin. • Fevers associated with louse or tick bites leaflet with larger • Malaria, when chloroquine is not effective erythematosus (an allergic condition that causes Not known: frequency cannot be estimated from text, please contact Doxycycline capsules are also used to prevent joint pain, skin rashes and fever). This condition the available data certain infections developing, these are scrub may be worsened by taking Doxycycline • discolouration and/or lack of growth of teeth 01271 385257. typhus (a disease carried by small insects) Rocky capsules. Continued top of next column 50994082 BBBA9053 Continued top of next column Continued over page

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