Curriculum Vitae Luis F. Parada, Ph.D. [email protected] 1275 York Avenue, Box 558 New York, NY 10065 T 646-888-3781 www.mskcc.org

Education & positions held

1979 B.S., Molecular Biology (with Honors), University of Wisconsin-Madison, Wisconsin

1985 Ph.D., Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts

1985 - 1987 Postdoctoral Fellow, Unité de Génetique Cellulaire, Pasteur Institute, Paris, France

1988 - 1994 Head, Molecular Embryology Group & Molecular Embryology Section (with tenure), Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland

1994 - 2006 Director, Center for Developmental Biology and Professor of Cell Biology University of Texas Southwestern Medical Center, Dallas, TX

1995 - 2015 Diana and Richard C. Strauss Distinguished Chair in Developmental Biology

1997 - 2015 Director, Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration

1998 - 2015 Southwestern Ball Distinguished Chair in Basic Neuroscience Research

2003 - American Cancer Society Research Professor

2006 - 2015 Chairman, Department of Developmental Biology, University of Texas Southwestern Medical School

2015- Director, Brain Tumor Center & Member Cancer Biology and Genetics Program, SKI & MSKCC

2015- Albert C. Foster Chair, SKI & MSKCC

2015- Attending Neuroscientist, Departments of Neurology and Neurosurgery, MSKCC

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Honors

2018 EACR Keynote Lecture. The 4th Brain Tumours 2018: From Biology to Therapy Conference. Warsaw, Poland. 2018 Keynote Lecture CRUK Brain Tumour Conference 2018. London 2016 - 2023 NCI Outstanding Investigator Award (R35) 2015 Distinguished Lectureship in Cancer Biology, MD Anderson 2014 The Maestro Award – Dallas, TX 2014 The Herman Vanden Berghe Lectures – University of Leuven, Belgium 2013 Blaffer Lecture – M.D. Anderson Cancer Center 2012 President’s Lecture - Memorial Sloan-Kettering Cancer Center 2012 Keynote Lecture Washington University Neurofibromatosis Center Symposium 2012 Keynote Lecture – Children’s Tumor Foundation, NF Conference 2011 Naomi Kanof Investigator Award Lectureship – Society for Investigative Dermatology 2011 Elected: National Academy of Science 2010 Balkin Lecture in Neuro-Oncology. Massachusetts General Hospital 2009 Peter A. Steck Memorial Lecture, M.D. Anderson Cancer Center 2009 Friedrich von Recklinghausen Award – Children’s Tumor Foundation 2009 Elected: Fellow of American Association for the Advancement of Science 2007 Elected: National Academy of Medicine (Former: Institute of Medicine). 2007 Elected: The American Academy of Arts and Sciences 2007 The Academy of Medicine, Engineering and Science of Texas (TAMEST) 2006 National Institute of Health Director’s Lecture 2005 First Christopher Reeve Memorial Lecture - University of Miami School of Medicine, The Miami Project to Cure Paralysis, 2004 Landau Neuro-oncology Distinguished Lecture - Washington University School of Medicine 2003 - Member, Dana Alliance for Brain Initiatives 2003 Presidents Lecture - Memorial Sloan-Kettering Cancer Center 2003 - American Cancer Society Research Professor 2003 Arthur & Sonia Labatt Lecture on Brain Tumors, Tumor Research Center, Hospital for Sick Children, Toronto, Canada 2002 Howard Hughes Distinguished Seminar, University of Iowa, College of Medicine, Iowa City, IA. 2001 University of Colorado Health Sciences Center. Dean’s Distinguished Seminar Series 2001 National Cancer Institute - FCRDC, Distinguished Scientist Seminar Series. 2000 Peter A. Steck Memorial Award - Society for Neuro-Oncology 2000 Carolyn Farb Endowed Lecture in Neurofibromatosis, MD Anderson Medical Center, Houston, TX. 1999 - 2006 Javits Merit Award - NIH-National Institute of Neurological Disorders and Stroke 1993 Boehringer University Lecture, Universidad Autonoma de Barcelona 1986 - 1987 Helen Hay Whitney Postdoctoral Fellowship 1985 - 1986 Damon Runyon-Walter Winchell Postdoctoral Fellowship Luis F. Parada Page 3 of 28

Service Current:

2019- CRUK International Children’s Brain Tumour Board 2018- External Advisory Board – UT Southwestern NCI-designated Cancer Center 2017-2023 Pew Latin American Fellow Committee 2009 - Training Program in Translational Brain Tumor Research, External Advisory Board, UCSF 2010 - Institute for Research in Biomedicine, Barcelona, External Advisory Board 2008 - Howard Hughes Medical Institute Scientific Review Board 2006 - Brain Tumor Center External Advisory Board- UCSF

Service Past: 2018 AACR 2019 Annual Meeting Program Committee 2018 Section 41 Screen and Search Committee - NAS 2018 The Knut and Alice Wallenberg Foundation Review Panel 2018 External Advisory Board UT Southwestern Cancer Center 2018 Ontario Institute for Cancer Research Translational Research Initiatives 2018 Cancer Research UK Expert Panel Interview 2017-2019 National Academy of Sciences Council Nominating Committee 2015-2019 External Advisory Board University of South Carolina Medical Center COBRE 2015 AACR 2016 Annual Meeting Program Committee 2015 American Brain Tumor Association (ABTA) Basic Research Fellowship Chairperson 2015 American Brain Tumor Association (ABTA) Basic Research Fellowship Committee 2014 - 2019 The Jane Coffin Childs Memorial Fund for Medical Research, Board of Scientific Advisors 2013 - 2019 American Brain Tumor Association (ABTA) Scientific Board 2013 - 2019 Chair, External Advisory Board Gilbert Family Neurofibromatosis Center, Children’s National Hospital, Washington, D.C. 2013 - 2015 Board - The Academy of Medicine, Engineering, and Science of Texas 2013 - 2014 Institute of Medicine (IOM) Interest Group 13 on Cancer, Stem Cell Biology & Transplantation Planning Committee. 2013 Howard Hughes Medical Institute New Investigator Competition Selection Panel 2013 Chair, The Academy of Medicine, Engineering and Science of Texas Annual Meeting 2011 - 2018 National Cancer Institute – Board of Scientific Advisors 2011, 2017 Simons Foundation Autism Research Initiative (SFARI) Review Panel 2011 - 2014 American Academy of Arts and Sciences Membership Panel (Medical Sciences) 2010 AACR – Chairperson of the Tumor Microenvironment Subcommittee of the Tumor Biology Section of the 2010 AACR Program Committee. Luis F. Parada Page 4 of 28

2009 - 2016 Brain Tumor Center External Advisory Board, Univ. of Texas, M.D. Anderson Cancer Center 2009 - 2010 American Academy of Arts and Sciences II:5 – Medical Sciences, Clinical Medicine, and Public Health Membership Section Panel 2009 AACR - Oncogenes and Tumor Suppressor Genes Subcommittee of the Cellular and Molecular Biology Section of the 2009 Program Committee 2008 - 2015 Brain Tumor Center External Advisory Board, Memorial Sloan Kettering Cancer Center 2008 - 2014 National Advisory Committee – Rett Syndrome Research Trust 2008 Howard Hughes Medical Institute Junior Faculty Competition Committee 2007 - 2014 Texans for Advancement of Medical Research Science Advisory Board 2007 - 2010 National Advisory Council for National Institute of Neurological Disorders and Stroke 2007 Howard Hughes Medical Institute Patient Oriented Research Investigator Competition Committee 2007 AACR - Animal Models and Other Model Organisms Subcommittee of the Tumor Biology Section of the 2007 Program Committee 2007 Ad Hoc Review – Howard Hughes Medical Institute 2006 - 2010 National Institutes of Health Neurosciences Institute and Centers – Cre-Driver Network Steering Committee 2006 - 2009 American Association for Cancer Research Publications Committee 2005 - 2011 National Advisory Committee – The Pew Scholars Program 2005 Children’s Tumor Foundation Medical Director Search Committee 2005 Co-organizer (with Drs. Mina Bissell and Ronald DePinho) of the 2005 Keystone Symposium, “The Role of Microenvironment in Tumor Induction and Progression” Banff, Alberta, Canada. February 2-20 2005 External Review Committee – UCLA Mental Retardation Research Center. 2004 - 2007 NexGenix Pharmaceuticals Scientific Advisory Board 2004 - 2006 Goldhirsh Foundation Scientific Advisory Committee 2004 NINDS - Neuroscience Blueprint Panel 2004 NIH Tumor Stem Cells and Self-Renewal Genes Think Tank 2003 - 2005 The Brain Tumor Society’s Herbert M. Karol Chair of Research 2002 - 2007 Scientific Board, Oklahoma Medical Research Foundation 2002 Program Committee, American Association for Cancer Research Meeting 2003 2002 Co-organizer (with Adrian Byrd) of the Rett Syndrome Foundation Symposium, Baltimore, MD. June 17-19 2002 Organizer workshop on Neurofibromatosis and Stem Cells, Keystone, CO. March 18 2001 - 2003 Search Committee, Director: NIH-National Institute of Neurological Disorders and Stroke 2001 Co-organizer (with Zach Hall) of the International Neurofibromatosis Conference, Aspen, CO. May 20-23 2001- 2005 Oversight Board, Developmental Neurobiology and Brian Tumor Program, St. Jude Children’s Research Hospital 2001 - National Institutes of Health - Mouse Genomics and Genetics Scientific Panel. 2001 - 2009 National Cancer Institute – Mouse Models of Human Cancer Consortium Luis F. Parada Page 5 of 28

2000 - 2003 Chair, Board of Scientific Counselors, National Institute of Neurological Disorders and Stroke-Division of Basic Science 2000 Review Panel - International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP) 2000 - 2004 Scientific Advisory Board - Rett Syndrome Research Foundation. 2000 - 2002 Promotions Committee - NIH - National Institute of Neurological Disorders and Stroke, Division of Basic Science 1999 - 2001 Institute Director’s Steering Committee for Extramural Affairs - NIH-National Institute of Neurological Disorders and Stroke 1999 - 2003 Scientific Advisory Council - Cancer Research Fund of the Damon Runyon- Walter Winchell Foundation 1999 - 2007 Scientific Advisory Board: Christopher Reeve Paralysis Foundation. 1999 Consultant for Millennium Pharmaceuticals 1999 - 2000 Chair: Advisory Panel to the Institute Director on Development, Plasticity, and Regeneration, NIH-National Institute of Neurological Disorders and Stroke 1998 – 2004 National Neurofibromatosis Foundation Research Advisory Board 1998 – 2003 Board of Scientific Counselors - NIH-National Institute of Neurological Disorders and Stroke, Division of Basic Science 1996 - 1998 Chair: NIH - Division of Research Grants, Neurosciences C Study Panel. 1995 - 1999 Board of Scientific Counselors - National Cancer Institute, Division of Basic Sciences 1995 Ad hoc Scientific Board Member National Institute of Mental Health LCB. 1994 - 1999 Scientific Advisory Board: American Paralysis Association 1993 - 1998 Member NIH DRG, Neuroscience-C Study Panel 1993 - 1994 Member Amyotrophic Lateral Sclerosis Foundation Review Committee. 1991 - 1994 Consultant for Genentech in Neuroscience 1991 - 1992 Consultant for Amgen 1990 - 1992 Organizer and Instructor: Cold Spring Harbor, Molecular Embryology of the Mouse Course 1990 Co-instructor: Cold Spring Harbor, Molecular Embryology of the Mouse Course 1985 Cold Spring Harbor, Molecular Embryology of the Mouse Course

Institutional & Academic Committees: Current:

2021 - Basic Research Coordinator, NCI Cancer Center Core Grant 2020 - MSKCC MH Translational Research Advisory Committee 2019 - Laboratory Emergency Task Force (LET) 2019 - MSKCC Basic Research Innovation Award (BRIA) 2018 - 2022 MSK Committee on Appointments and Promotions (COAP) 2017 - SKI Cancer Biology & Genetics Executive Committee 2015 - MSKCC Cycle for Survival Executive Committee 2015 - SKI Steering Committee

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Past:

2019 MSKCC Neurology Chair Search Committee 2017 - 2019 MSKCC Pancreas Center-Search Committee 2017 MSKCC Neurosurgery Chair Search Committee 2016 - 2020 SKI Committee on Appointments and Promotions (SKICAP) 2015 - 2019 Gerstner Sloan Kettering Graduate School of Biomedical Sciences – Steering Committee 2014 - 2015 UT Southwestern Internal Advisory Board for Cancer Center Grant 2010 - 2015 UT Southwestern Six-Year Plan Oversight Committee 2008 - 2015 UT Southwestern Liaison Committee on Medical Education (LCME) Steering Committee 2006 - 2015 UT Southwestern Steering Committee: Endowed Scholars Program in Biomedical Science 2005 - 2015 UT Southwestern Steering Committee: Disease-Oriented and Clinical Research Scholars Program 2002 - 2015 UT Southwestern Executive Committee Simmons Comprehensive Cancer Center 2002 - 2015 UTSW Core Facilities Committee 2002 - 2015 UTSW Faculty Council 2001 - 2015 UT Southwestern Microarray Facility Advisory Committee 2001 - 2015 UT Southwestern External Advisory Board for Center for Developmental Nephrology 2001 - 2015 UT Southwestern Advisory Committee for Institute for Innovations in Medical Technologies 1998 - 2015 UT Southwestern Mobility Foundation Center Internal Advisory Board 1997 - 2015 UT Southwestern Steering Committee: Division Cell & Molecular Biology Training Grant 1997 - 2015 UT Southwestern Advisory Committee: Animal Resource Center 1996 - 2015 UT Southwestern Six Year Research Planning Committee 1996 - 2015 UT Southwestern Ad hoc Committee Core Facilities to Support Basic Research 1996 - 2015 UT Southwestern Genetics & Development Graduate Program Qualifying Examination Committee 1995 - 2015 UT Southwestern Steering Committee: Medical Scientist Training Program 1995 - 2012 UT Southwestern Institutional Six-Year Planning Committee on Basic Science Education 1995 - 2015 UT Southwestern Institutional Animal Care and Research Committee 1994 - 2015 UT Southwestern Steering Committee: Neuroscience Graduate Program 1994 - 2015 UT Southwestern Dean’s Advisory Committee 2010 - 2011 Search Committee: Chair of Pathology 2008 Search Committee: Chair, Department of Neuroscience 2007 Chair, Search Committee: Director, Green Center for Reproductive Biology 2006 Search Committee: Dean, Southwestern Medical School 2005 - 2006 Search Committee: Chair, Department of Pharmacology Luis F. Parada Page 7 of 28

2005 Search Committee: Chair, Department of Dermatology 2005 Search Committee: Chair, Neuro-Oncology

2005 Search Committee: Chair, Department of Obstetrics & Gynecology 2004 - 2005 Search Committee: Dean, Southwestern Medical School 2004 Interim Director Simmons Comprehensive Cancer Center 2003 - 2004 Program Leader, Animal Tumor Models Program, Cancer Center 2002 - 2004 Chair, Search Committee: Director, Simmons Cancer Center. 2001 - 2008 UT Southwestern Pediatric Clinical/Academic Integration Committee and the Children’s Medical Center Academic Affairs Committee 1998 - 2000 Search Committee: Chair, Department of Psychiatry 1997 - 2000 Organizer and Instructor, Human Embryology, first year medical curriculum 1996 - 2000 Medical Education and Curriculum Committee-Consultant (1st Year) 1996 Search Committee: Animal Resources Center Director 1995 - 1998 Mobility Foundation Center Director Search Committee 1995 - 1996 Committee to audit the Animal Resources Center 1994 - 1998 Search Committee: Chair, Center for Neuroscience 1994 - 1996 Search Committee: Director, Simmons Cancer Center 1994 Liaison Committee on Medical Education 1993 - 1994 ABL- NCI, Tenure and Promotions Committee 1990 - 1992 Organizer and Instructor: Cold Spring Harbor, Molecular Embryology of the Mouse Course 1989 - 1994 ABL Basic Research Program - NCI, Standing Search Committee

Journals Refereed

Cancer Research; Cell; Cancer Cell; Developmental Cell; Cell Communications; Cell Stem Cell; Development; Developmental Biology; European Journal of Neuroscience; Genes & Development; Journal of Biological Chemistry; Journal of Cell Biology; Journal of Neuroscience; Mechanisms of Development, Molecular and Cellular Biology; Nature; Nature Genetics, Nature Biotechnology, Nature Medicine, Nature Neuroscience, New England Journal of Medicine; Neuron; Oncogene; Proceedings of the National Academy of Sciences, U.S.A.; Science; Nature Structural & Molecular Biology; Public Library of Science.

Patents:

Assay for Pharmacological Agents that block Neurofibromin Action By: L.F. Parada and K. Vogel. Trk Tyrosine Kinase Receptor is the Physiological Receptor for Nerve Growth Factor By: D. Kaplan and L.F. Parada. Novel Compound Induces Apoptosis in Malignant Peripheral Nerve Sheath Tumors By: L.Q. Le, S. K. Lim, V. Chau, and L.F. Parada

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Publications

1. Parada, L.F., Tabin C.J., Shih, C. and Weinberg, R.A. 1982. “Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene.” Nature. Vol. 297(5866): 474- 479. 2. Murray, M.J., Shih, C., Parada, L.F., Tabin, C. and Weinberg, R.A. 1982. “Characterization of Human Tumor Cell Transforming Genes.” Cetus-UCLA Symposium. 3. Murray, M.J., Cunningham, J.M., Parada, L.F., Dautry, F., Lebowitz, P. and Weinberg, R.A. 1983. “The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors.” Cell. Vol. 33(3): 749-757. 4. Land, H., Parada, L.F. and Weinberg, R.A. 1983. “Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.” Nature. Vol. 304(5927): 596-602. 5. Land, H., Parada, L.F. and Weinberg, R.A. 1983. “Cellular oncogenes and multistep carcinogenesis.” Science. Vol. 222(4625): 771-778. 6. Parada, L.F. and Weinberg, R.A. 1983. “Presence of a kirsten murine sarcoma virus ras oncogene in cells transformed by 3-methylcholanthrene.” Mol. Cell. Biol. Vol. 3(12): 2298-2301. PMC370101 7. Parada, L.F., Shih, C., Murray, M. and Weinberg, R.A. 1983. “The oncogene of a human bladder carcinoma.” In: Progress in Nucleic Acid Research and Molecular Biology 29, (W.E. Cohn, editor), Academic Press, NY. 8. Lenoir, G.M., Land, H., Parada, L.F., Cunningham, J.M. and Weinberg, R.A. 1984. “Activated oncogenes in Burkitt’s lymphoma.” In: Current Topics in Microbiology and Immunology 113: Springer-Verlag Berlin, Heidelberg. 9. Schechter, A., Stern, D.F., Vaidyanathan, L., Land, H., Parada, L.F. and Weinberg, R.A. 1984. “Interacting Oncogenes In: Molecular Biology of Tumor Cells.” (B. Wahren, editor), Raven Press, NY. 10. Weinberg, R.A. and Parada, L.F. 1984. “Report of the Research Briefing Panel on the Biology of Oncogenes.” p. 57-67. In: Research Briefings 1984, National Academy Press. 11. Parada, L.F., Land, H., Weinberg, R.A., Wolf, D. and Rotter, V. 1984. “Cooperation between gene encoding p53 tumor antigen and ras in cellular transformation.” Nature. Vol. 312(5995): 649-651. 12. Land H., Parada, L.F. and Weinberg, R.A. 1984. “Cellular and viral oncogenes cooperate to achieve tumorigenic conversion of rat embryo fibroblasts. In: Cancer Cells/2 Oncogenes and Viral Genes.” (Vande Woude et al., editors), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 13. Parada, L.F., Land, H., Chen, A., Morgenstern, J. and Weinberg, R.A. 1985. “Cooperation between cellular oncogenes in the transformation of primary rat embryo fibroblasts.” Prog. Med. Virol. Vol. 32: 115-128. 14. Dotto, G.P., Parada, L.F. and Weinberg, R.A. 1985. “Specific growth response ras- transformed embryo fibroblasts to tumor promoters.” Nature. Vol. 318: 472-475. Luis F. Parada Page 9 of 28

15. Land, H., Chen, A.C., Morgenstern, J.P., Parada, L.F. and Weinberg, R.A. 1986. “Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.” Mol. Cell. Biol. Vol. 6(6): 1917-1925. 16. Klein, R., Parada, L.F., Coulier, F. and Barbacid, M. 1989. “TrkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.” EMBO J. Vol. 8(12): 3701- 3709. PMC402053 17. Martin-Zanca, D., Barbacid, M. and Parada, L.F. 1990. “Expression of the trk proto- oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.” Genes & Development. Vol. 4(5): 683-694. 18. Klein, R., Conway, D., Parada, L.F. and Barbacid, M. 1990. “The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain.” Cell. Vol. 61(4): 647-656. 19. Klein, R., Martin-Zanca, D., Barbacid, M. and Parada, L.F. 1990. “Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system.” Development. Vol. 109(4): 845-850. 20. Stanton, B.R., Reid, S.W. and Parada, L.F. 1990. “Germ line transmission of an inactive Nmyc allele generated by homologous recombination in mouse embryonic stem cells.” Mol. Cell. Biol. Vol. 10(12): 6755-6758. PMC362953 21. Martin-Zanca, D., Klein, R., Barbacid, M. and Parada, L.F. 1990. “Specific expression of the trk protein tyrosine kinase receptor gene family in the murine embryonic and mature nervous system.” In: The Avian Model In Developmental Biology from Organism to Genes (Le Douarin, N., Dieterlen-Lievre, F., and Smith, J. eds.), Paris, France, pp. 291-302. 22. Klein, R., Conway, D., Parada, L.F. and Barbacid, M. 1990. “trkB, A novel tyrosine protein kinase gene codes for two types of putative neurogenic cell surface receptors.” UCLA Symposium on Molecular Neurobiology, April 17-23, 1990. 23. Parada, L.F. and Martin-Zanca, D. 1990. “Oncogene File: trk.” In: Cancer Cells: A Monthly Review, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 24. Kaplan, D. R., Martin-Zanca, D. and Parada, L.F. 1991. “Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.” Nature. Vol. 350(6314): 158-160. 25. Kaplan, D.R., Hempstead, B.L., Martin-Zanca, D., Chao, M.V. and Parada, L.F. 1991. “The trk proto-oncogene product: A signal transducing receptor for Nerve Growth Factor.” Science. Vol. 252(5005): 554-558. 26. Nebreda, A.R., Martin-Zanca, D., Kaplan, D.R., Parada, L.F. and Santos, E. 1991. “Induction by NGF of meiotic maturation of Xenopus oocytes expressing the trk protooncogene product.” Science. Vol. 252(5005): 558-560. 27. Hempstead, B.L., Martin-Zanca, D., Kaplan, D.R., Parada, L.F. and Chao, M.V. 1991. “High-affinity NGF binding requires co-expression of the trk proto-oncogene product and the low affinity NGF receptor.” Nature. Vol. 350(6320): 678-683. 28. Soppet, D., Escandon, E., Maragos, J., Middlemas, D.S., Reid, S.W., Blair, J., Burton, L. E., Stanton, B.R., Kaplan, D.R., Hunter, T., Nikolics, K. and Parada, L.F. 1991. “The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor.” Cell. Vol. 65(5): 895-903. 29. Vetter, M.L., Martin-Zanca, D., Parada, L.F., Bishop, J.M. and Kaplan, D.R. 1991. “Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-g1 by a kinase Luis F. Parada Page 10 of 28

activity associated with the product of the trk proto-oncogene.” Proc. Natl. Acad. Sci., U.S.A. Vol. 88(13): 5650-5654. PMC51935 30. Keshet, E., Lyman, S.D., Williams, D.E., Anderson, D.M., Jenkins, N.A., Copeland, N.G. and Parada, L.F. 1991. “Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development.” EMBO J. Vol. 10(9): 2425-2435. 31. Loeb, D.M., Maragos, J., Martin-Zanca, D., Chao, M.V., Parada, L.F. and Greene, L.A. 1991. “The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines.” Cell. Vol. 66(5): 961-966. 32. Berg, M.M., Sternberg, D.W., Parada, L.F. and Chao, M.V. 1992. “K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity.” J. Biol. Chem. Vol. 267(1): 13-16. 33. Tessarollo, L., Nagarajan, L. and Parada, L.F. 1992. “c-ros: the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development.” Development. Vol. 115(1): 11-20. 34. Holtzman, D.M., Li, Y., Parada, L.F., Kinsman, S., Chen, C-K, Valletta, J.S., Zhou, J., Long, J.B. and Mobley, W.C. 1992. “p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF.” Neuron. Vol. 9(3): 465- 478. 35. Hempstead, B.L., Rabin, S.J., Kaplan, L., Reid, S., Parada, L.F. and Kaplan, D.R. 1992. “Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation.” Neuron. Vol. 9(5): 883-896. 36. Stanton, B.R., Perkins, A.S., Tessarollo, L., Sassoon, D.A. and Parada, L.F. 1992. “Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop." Genes & Development. Vol. 6(12A): 2235-2247. 37. Parada, L.F., Tsoulfas, P., Tessarollo, L., Blair, J., Reid, S.W. and Soppet, D. 1992. “The Trk family of tyrosine kinases: Receptors for NGF-related neurotrophins.” Cold Spring Harbor Symposia on Quantitative Biology LVII. 43-51. 38. Stanton, B.R. and Parada, L.F. 1992. “The N-myc proto-oncogene: Developmental expression and in vivo site-directed mutagenesis.” Brain Pathology. Vol. 2(1): 71-83. 39. Parada, L.F. 1992. “Trk receptors: BDNF functions through trkb.” Neuroscience Facts. Vol. 3: 7. 40. Tsoulfas, P., Soppet, D., Escandon, E., Tessarollo, L., Mendoza-Ramirez, J-L., Rosenthal, A., Nikolics, K. and Parada, L.F. 1993. “The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells.” Neuron. Vol. 10(5): 975-990. 41. Tessarollo, L., Tsoulfas, P., Martin-Zanca, D., Gilbert, D.J., Jenkins, N.A., Copeland, N.G. and Parada, L.F. 1993. “trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.” Development. Vol. 118(2): 463- 475. 42. Lindholm, D., Castrén, E., Tsoulfas, P., Kolbeck, R., da Penha Berzaghi, M., Leingärtner, A., Heisenberg, C-P., Tessarollo, L., Parada, L.F. and Thoenen, H. 1993. “Neurotrophin- 3 induced by tri-iodothyronine in cerebellar granule cells promotes purkinje cell differentiation.” J. Cell Biology. Vol. 122(2): 443-450. PMC2119654 43. Zhou, X-F., Parada, L.F., Soppet, D. and Rush, R.A. 1993. “Distribution of trkB tyrosine kinase immunoreactivity in the rat central nervous system.” Brain Research. Vol. 622(1- 2): 63-70. Luis F. Parada Page 11 of 28

44. Moens, C.B., Stanton, B.R., Parada, L.F. and Rossant, J. 1993. “Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc Locus.” Development. Vol. 119: 485-499. 45. Chao, M.V. and Parada, L.F. 1993. “Nerve growth factor receptors in the developing nervous system.” Receptors in the Developing Nervous System. Vols. 1 and 2: 27-38. 46. Escandon, E., Soppet, D., Rosenthal, A., Mendoza-Ramírez, J-L., Szönyi, E., Burton, L.E., Henderson, C.E., Parada, L.F. and Nikolics, K. 1994. “Regulation of neurotrophin receptor expression during embryonic and postnatal development.” J. Neuroscience. Vol. 14(4): 2054-2068. 47. Xu, H., Federoff, H., Maragos, J., Parada, L.F. and Kessler, J.A. 1994. “Viral transduction of trkA into cultured nodose and spinal motor neurons conveys NGF responsiveness.” Developmental Biology. Vol. 163(1): 152-161. 48. Brannan, C.I., Perkins, A.S., Ratner, N., Nordlund, M., Reid, S.W., Vogel, K., Buchberg, A., Jenkins, N.A., Parada, L.F. and Copeland, N.G. 1994. “Targeted disruption of the neurofibromatosis type I gene leads to abnormalities in heart and various neural crest-derived tissue.” Genes & Development. Vol. 8(9): 1019-1029. 49. Tessarollo, L., Vogel, K. S., Palko, M.E., Reid, S.W. and Parada, L.F. 1994. “Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons.” Proc. Natl. Acad. Sci. U.S.A. Vol. 91(25): 11844-11848. PMC45332 50. Urfer, R., Tsoulfas, P., Soppet, D., Escandon, E., Parada, L.F. and Presta, L.G. 1994. “Design of a protein with multiple neurotrophic specificities by mutational analysis of the interaction of neurotrophin-3 with its receptors trkC and p75.” EMBO J. Vol. 13(24): 5896- 5909. 51. Donovan, M.J., Hempstead, B., Huber, L.J. Kaplan, D., Tsoulfas, P., Chao, M., Parada, L.F. and Schofield, D. 1994. “Identification of the neurotrophin receptors p75 and trk in a series of Wilm’s tumors.” Am. J. Path. Vol. 145(4): 792-801. PMC1887328 52. Averbuch, -Heller L., Pruginin, M., Kahane N., Tsoulfas, P., Parada, L.F., Rosenthal, A. and Kalcheim, C. 1994. “Neurotrophin 3 stimulates the differentiation of motoneurons from avian neural tube progenitor cells.” Proc. Natl. Acad. Sci., U.S.A. Vol. 91(8): 3247-3251. PMC43553 53. Slaughenhaupt, S., Blumenfeld, A., Liebert, C., Mull, J. Lucente, D. E., Monahan, M., Breakefield, X.O., Axelrod, F., Maayan, C., Parada, L.F. and Gusella, J.F. 1994. “The human gene for neurotrophic tyrosine kinase receptor type 2 is located on Chromosome 9 and is not the Familial Dysautonomia Gene.” Genomics. Vol. 25(3): 730-732. 54. Donovan, M.J., Miranda, R., Kraemer, R., McCaffrey, T., Tessarollo, L., Mahadeo, D., Sharif, S., Kaplan, D.R., Tsoulfas, P., Parada, L.F., Toran-Allerand, D., Haijar, D.P. and Hempstead, B. 1994. “Neurotrophin and neurotrophin receptors in vascular smooth muscle cells: regulation of expression in response to injury.” Am. J. Path. Vol. 147(2): 309-324. PMC1869811 55. Urfer, R., Tsoulfas, P., Soppet, D., Escandon, E., Parada, L.F. and Presta, L.G. 1994. “The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin.” EMBO J. Vol. 13(24): 5896-5909. PMC395565 56. Shikata, A., Sugimoto, T., Hosoi, H., Sotozono, Y., Shikata, T., Sawada, T. and Parada, L.F. 1994. “Increased expression of trk proto-oncogene by g-interferon in human neuroblastoma cell lines.” Jpn. J. Cancer Res. Vol. 85(2): 122-126. Luis F. Parada Page 12 of 28

57. Offenhauser, N., Bohm-Matthaei, R., Tsoulfas, P., Parada, L.F. and Meyer, M. 1995. “Developmental regulation of full length trkC in the rat sciatic nerve.” Eur. J. Neuroscience. Vol. 7: 917-925. 58. Urfer, R., Tsoulfas, P., O’Connell, L., Shelton, D.L., Parada L.F. and Presta, L.G. 1995. “An immunogloblin-like domain determines the specificity of neurotrophin receptors.” EMBO J. Vol. 14(12): 2795-2805. PMC398398 59. Vogel, K.S., Brannan, C.I., Jenkins, N.A., Copeland, N.G. and Parada, L.F. 1995. “Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons.” Cell. Vol. 82(5): 733-742. 60. Tessarollo, L. and Parada, L. F. 1995. “In situ hybridization.” Methods in Enzymology. Vol. 254: 419-430. 61. Tsoulfas, P., Stephens, R.M., Kaplan, D.R. and Parada, L.F. 1996. “TrkC isoforms with inserts in the kinase domain show impaired signaling responses.” J. Biol. Chem. Vol. 271(10): 5691-5697. 62. Nelson, C.E., Morgan, B.A., Burke, A.C., Laufer, E., DiMambro, E., Murtaugh, L.C., Gonzales, E., Tessarollo, L., Parada, L.F. and Tabin, C. 1996. “Analysis of Hox gene expression in the chick limb bud.” Development. Vol. 122(5): 1449-1466. 63. Dechant, G., Tsoulfas, P., Parada, L.F. and Barde Y-A. 1997. “The neurotrophin receptor p75 binds neurotrophin-3 on sympathetic neurons with high affinity and specificity.” J. Neuroscience. Vol. 17(14): 5281-5287. 64. Bates, C., Merenmies, J.M., Kelly-Spratt, K.S. and Parada, L.F. 1997. “Insulin receptor- related receptor expression in non-A intercalated cells in the kidney.” Kidney International. Vol. 52(3): 674-681. 65. Liebl, D.J., Tessarollo, L., Palko, M.E. and Parada, L.F. 1997. “Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin3-, and TrkC-deficient embryonic mice.” J. Neuroscience. Vol. 17(23): 9113-9121. 66. Tessarollo, L., Tsoulfas, P., Donovan, M.J., Palko, M.E., Blair-Flynn, J., Hempstead, B.L. and Parada, L.F. 1997. “Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis.” Proc. Natl. Acad. Sci., U.S.A. Vol. 94(26): 14776-14781. PMC25113 67. Merenmies, J., Parada, L.F. and Henkemeyer, M. 1997. “Receptor tyrosine kinase signaling in vascular development.” Cell Growth & Differentiation. Vol. 8(1): 3-10. 68. Vogel, K.S. and Parada, L.F. 1998. “Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin.” Mol. Cell. Neuro. Vol. 11(1-2): 19-28. 69. Zhu, Y., Richardson, J.A., Parada, L.F.* and Graff, J.M. 1998. “Smad3 mutant mice develop metastatic colorectal cancer.” Cell. Vol. 94(6): 703-714. (*corresponding author) 70. Klesse L.J. and Parada, L.F. 1998. “p21 Ras and phosphatidylinositol-3 kinase are required for survival of wildtype and NF1 mutant sensory neurons.” J. Neuroscience. Vol. 18(24): 10420-10428. 71. Kahn, M.A., Kumar, S., Liebl, D., Chang, R., Parada, L.F. and deVellis, J. 1999. “Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells.” Glia. Vol. 26(2): 153-165. 72. Klesse L.J., Meyers K.A., Marshall, C.J. and Parada, L.F. 1999. “Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells.” Oncogene. Vol. 18(12): 2055-2068. Luis F. Parada Page 13 of 28

73. Nef, S. and Parada, L.F. 1999. “Cryptorchidism in mice mutant for Ins13.” Nature Genetics. Vol. 22(3): 295-299. 74. Liebl, D.J., Mbiene, J.P. and Parada, L.F. 1999. “NT4/5 mutant mice have deficiency in gustatory papillae and taste bud formation.” Dev. Biology. Vol. 213(2): 378-389. 75. Ma, L., Reis, G., Parada, L.F. and Schuman, E.M. 1999. “Neuronal NT-3 is not required for synaptic transmission or long-term potentiation in area CA1 of the adult rat hippocampus.” Learning and Memory. Vol. 6(3): 267-275. PMC311298 76. Vogel, K.S., Klesse, L.J., Velasco-Miguel, S., Meyers, K., Rushing, E.J. and Parada, L.F. 1999. “Mouse tumor model for neurofibromatosis Type 1.” Science. Vol. 286(5447): 2176- 2179. PMC3079436 77. Kelly-Spratt, K.S., Klesse, L.J., Merenmies, J. and Parada, L.F. 1999. “A TrkB/IRR chimeric receptor induces PC12 cell differentiation and exhibits prolonged activation of MAP kinase.” Cell Growth & Differentiation. Vol. 10(12): 805-812. 78. Klesse L.J. and Parada, L.F. 1999. “Trks: Signal transduction and intracellular pathways.” Microscopy Research and Technique. Vol. 45(4-5): 210-216. 79. McDonald, J.W. and the Research Consortium of the Christopher Reeve Paralysis Foundation. 1999. “Repairing the damaged spinal cord.” Scientific American. Vol. 281(3): 64-73. 80. Gonzalez-Zulueta, M., Feldman, A.B., Klesse, L.J., Kalb, R.G., Dillman, J.F., Parada, L.F., Dawson, T.M. and Dawson, V.L. 2000. “Requirement for nitric oxide activation of p21ras/extracellular regulated kinase in neuronal ischemic preconditioning.” Proc. Natl. Acad. Sci., U.S.A. Vol. 4: 97(1): 436-441. PMC26681 81. Liebl D.J., Klesse L.J., Tessarollo L., Wohlman T. and Parada, L.F. 2000. “Loss of brain- derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin- 4 mutant mice.” Proc. Natl. Acad. Sci., U.S.A. Vol. 97(5): 2297-2302. PMC15795 82. Kernie, S.G., Liebl, D.J. and Parada, L.F. 2000. “BDNF regulates eating behavior and locomotor activity in mice.” EMBO J. Vol. 19(6): 1290-1300. 83. Bates, C.M., Kharzai, S., Erwin, T., Rossant, J. and Parada, L.F. 2000. “Role of N-myc in the developing mouse kidney.” Developmental Biology. Vol. 222(2): 317-325. 84. Vogel, K.S., El-Afandi, M. and Parada, L.F. 2000. “Neurofibromin negatively regulates neurotrophin signalling through p21ras in embryonic sensory neurons.” Mol. Cell. Neuro. Vol. 15(4): 398-407. 85. Nef, S., Shipman, T. and Parada, L.F. 2000. “A molecular basis for estrogen-induced cryptorchidism.” Developmental Biology. Vol. 224(2): 354-361. 86. Ma, L., Merenmies, J. and Parada, L.F. 2000. “Molecular characterization of the TrkA/NGF receptor minimal enhancer reveals regulation by multiple cis elements to drive embryonic neuron expression.” Development. Vol. 127(17): 3777-3788. 87. Nef, S. and Parada, L.F. 2000. “Hormones in male sexual development.” Genes & Development. Vol. 14(24): 3075–3086. 88. Kernie, S.G. and Parada, L.F. 2000. “The molecular basis for understanding neurotrophins and their relevance to neurologic disease.” Archives for Neurology. Vol. 57(5): 654-657 89. Parada, L.F. 2000. “Neurofibromatosis Type 1.” BBA. Vol. 147: M13-M19. 90. Yokoyama, N.*, Romero, M.I.*, Cowan, C.A., Galvan, P., Helmbacher, F., Charnay, P., Parada, L.F. and Henkemeyer, M. 2001. “Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline.” Neuron. Vol. 29(1): 85–97. (* co-first authors) 91. Liebl, D.J., Huang, W., Young, W. and Parada, L.F. 2001. “Regulation of Trk receptors Luis F. Parada Page 14 of 28

following contusion of the rat spinal cord.” Experimental Neurology. Vol. 167(1): 15-26. 92. Nef, S., Lush, M.E., Shipman, T.E. and Parada, L.F. 2001. “Neurotrophins are not required for normal embryonic development of olfactory neurons.” Developmental Biology. Vol. 234(1): 80-92. 93. Zhu, Y., Romero, M., Ghosh, P., Charnay, P., Rushing, E.J., Marth, J. and Parada, L.F. 2001. “Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the CNS and PNS.” Genes & Development. Vol. 15(7): 859- 876. PMC312666 94. Zhu, Y. and Parada, L.F. 2001. “Neurofibromin, a tumor suppressor of the nervous system.” Exp. Cell Research. Vol. 264: 19-28. 95. Lei L., Ma, L., Nef, S., Thai, T. and Parada, L.F. 2001. “mKlf7, a potential transcriptional regulator of TrkA nerve growth factor receptor expression in sensory and sympathetic neurons.” Development. Vol. 128(7): 1147-1158. 96. Kitamura, T., Kido, Y., Nef, S., Merenmies, J., Parada, L.F. and Accili, D. 2001. “Preserved pancreatic cell development and function in mice lacking the insulin receptor-related receptor.” Mol. Cell. Biology. Vol. 21(16): 5624-30. PMC87283 97. Kubota, Y., Nef, S., Farmer, P.J., Temelcos, C., Parada, L.F. and Hutson, J.M. 2001. “Leydig insulin-like hormone, gubernacular development and testicular descent.” J. Urology. Vol. 165(5): 1673-1675. 98. Schonhoff, C.M., Bulseco, D.A., Brancho, D.M., Parada, L.F. and Ross, A.H. 2001. “The Ras-ERK pathway is required for the induction of neuronal nitric oxide synthase in differentiating PC12 cells.” J. Neurochemistry. Vol. 78(3): 631-639. 99. Plum L.A., Parada L.F., Tsoulfas P. and Clagett-Dame M. 2001. “Retinoic acid combined with Neurotrophin-3 enhances the survival and neurite outgrowth of embryonic sympathetic neurons.” Experimental Biology and Medicine. Vol. 226(8): 766-775. 100. Honarpour, N., Tabuchi, K., Stark, Hammer, R.E., Sudhof, T.C, Parada, L.F., Wang, X., Richardson J.A. and Herz, J. 2001. “Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.” Neuroscience. Vol. 106(2): 263-274. 101. Kernie, S.G., Erwin, T.M. and Parada, L.F. 2001. “Brain remodeling due to neuronal and astrocytic proliferation following controlled cortical injury in mice.” J. Neuroscience Res. Vol. 66(3): 317-326. 102. Gutmann, D., Wu, Y.L., Hedrick, N.M., Zhu, Y., Guha, A. and Parada, L.F. 2001. “Heterozygosity for the neurofibromatosis 1 (NF1) tumor suppressor results in abnormalities in cell attachment, spreading and motility in astrocytes.” Human Molecular Genetics. Vol. 10(26): 3009-3016. 103. Zhu, Y. and Parada, L.F. 2001. “A particular GAP in mind.” Nature Genetics. Vol. 27(4): 354-356. 104. Nef, S., Verma-Kurvari, S., Shipman, T.E. and Parada, L.F. 2001. “Molecular genetics of Insl3.” Tregear, G.W., Ivell, R., Bathgate, R.A. and Wade, J.D. (eds.) Relaxin 2000. Proceedings of the 3rd International Conference on Relaxin & Related Peptides. Kluwer- ESCOM, Dordrecht. 337-335. 105. Kelly-Spratt, K.S., Klesse, L.J. and Parada, L.F. 2002. “A BDNF activated TrkB/IRR receptor chimera promotes survival of sympathetic neurons through ras and PI-3 kinase signaling.” J. Neuroscience Res. Vol. 15: 69(2): 151-9. 106. Zhu, Y., Ghosh, P., Charnay, P., Burns, D.K. and Parada, L.F. 2002. “Neurofibromas in NF1:Schwann cell origin and role of tumor environment.” Science. Vol. 296(5569): 920- Luis F. Parada Page 15 of 28

922. PMC3024710 107. Baker, L.A., Nef, S., Nguyen, M.T., Pohl, H., Barthold, J.S. and Parada, L.F. 2002. “The Insulin-3 (Insl3) gene: lack of a genetic basis for human cryptorchidism.” J. Urology. Vol. 167(6): 2534-7. 108. Bajenaru, M.L.*, Zhu, Y.*, Hedrick N.M., Donahoe, J., Parada, L.F. and Gutmann, D.H. 2002. “Astrocyte-specific inactivation of the neurofibromatosis 1 (NF1) gene is insufficient for astrocytoma formation.” Mol. Cell Biology. Vol. 15: 22(14): 5100-5113. (*co-first authors) PMC139771 109. Li, H., Velasco-Miguel, S., Vass, W.C., Parada, L.F. and DeClue, J.E. 2002. “Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the NF1:p53 mouse tumor model.” Cancer Research. Vol. 62(15): 4507-4513. 110. Zhu, Y. and Parada, L.F. 2002. “The molecular and genetic basis of neurologic tumours.” Nature Reviews on Cancer. Vol. 2(8): 616-626. 111. Nguyen, M.T., Showalter, P.R., Timmons, C.F., Nef, S., Parada, L.F. and Baker, L.A. 2002. “Effects of orchiopexy on congenitally cryptorchid Insulin-3 knock out mice.” J. Urology. Vol. 168(4 Pt 2): 1779-1788. 112. Harada, T., Harada, C., Kohsaka, S., Yoshida, K., Ohno, S., Parada, L.F. and Wada, K. 2002. “Microglia-muller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration.” J. Neuroscience. Vol. 22(21): 9228-36. 113. Ma, L., Harada, T., Harada, C., Romero, M., Hebert, J.M., McConnell, S.K. and Parada, L.F. 2002. “Neurotrophin-3 is required for appropriate establishment of thalamocortical connections.” Neuron. Vol. 36(4): 623-634. 114. Liebl, D.J., Henkemeyer, M. and Parada, L.F. 2003. “mRNA expression of Ephrins and Eph receptor tyrosine kinases in the neonatal and adult mouse central nervous system.” J. Neuroscience Res. Vol. 71(1): 7-22. 115. Luikart B.W., Nef, S., Shipman, T. and Parada, L.F. 2003. “In Vivo role of truncated TrkB receptors during sensory ganglion neurogenesis.” Neuroscience. Vol. 117(4): 847-858. 116. Bron, R., Klesse, L.J., Shah, K., Parada, L.F. and Winter, J. 2003. “Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type1 in sensory neurons by neurotrophic factors.” Molecular and Cellular Neuroscience. Vol. 22(1): 118-132. 117. Gitler, A.D.*, Zhu, Y.*, Ismat, F.A., Lu, M.M., Yamauchi, Y., Parada, L.F. and Epstein, J.A. 2003. “NF1 has an essential role in endothelial cells.” Nature Genetics. Vol. 33(1): 75-79. (*co-first authors). PMC3079412 118. Ma, L., Lei, L., Eng, S.R., Turner, E. and Parada L.F. 2003. “Brn3a regulation of TrkA NGF receptor expression in developing sensory neurons.” Development. Vol. 15: 3525- 3534. 119. Nef, S., Verma-Kurvari, S., Merenmies, J., Vassalli, J.D., Efstratiadis, A., Accili, D. and Parada, L.F. 2003. “Testis determination requires insulin receptor family function in mice.” Nature. Vol. 426(6964): 291-295. 120. Harada, C., Harada, T., Quah, H.M., Maekawa, F., Yoshida, K., Ohno, S., Wada, K., Parada, L.F. and Tanaka, K. 2003. “Potential role of glial cell line-derived neurotrophic factor receptors in Muller glial cells during light-induced retinal degeneration.” Neuroscience. Vol. 122(1): 229-235. 121. Bajenaru, M.L., Hernandez, M.R., Perry, A., Zhu, Y., Parada, L.F., Garbow, J.R. and Gutmann, D.H. 2003. “Optic nerve glioma in mice requires astrocyte NF1 gene inactivation and NF1 brain heterozygosity.” Cancer Research. Vol. 63(24): 8573-8577. 122. Le, D.T., Kong, N., Zhu, Y., Aiyigari, A., Raun, B.S., Wang, E., Kogan, S.C., Le Beau, Luis F. Parada Page 16 of 28

M.M., Parada L.F. and Shannon, K.M. 2004. “Somatic inactivation of NF1 in hematopoietic cells results in a progressive myeloproliferative disorder.” Blood. Vol. 103(11): 4243-50. 123. Verma-Kurvari, S. and Parada, L.F. 2004. “Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.” Developmental Dynamics. Vol. 230(4): 660-5. 124. Danzer, S.C., Pan, E., Nef, S., Parada, L.F. and McNamara, J.O. 2004. “Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation.” Neuroscience. Vol. 126(4): 859-69. 125. He, X.P., Kotloski, R., Nef, S., Luikart, B.W., Parada, L.F. and McNamara, J.O. 2004. “Conditional deletion of TrkB, but not BDNF, prevents epileptogenesis in the kindling model.” Neuron. Vol. 43(1): 31-42. 126. Harada, C., Harada, T., Quah, H.M., Namekata, K., Yoshida, K., Ohno, S., Tanaka, K. and Parada, L.F. 2005. “Role of neurotrophin-4/5 in neural cell death during retinal development and ischemic retinal injury in vivo.” Investigative Ophthalmology & Visual Science. Vol. 46(2): 669-673. 127. Yu, T.S., Dandekar, M., Monteggia, L.M., Parada, L.F. and Kernie, S.G. 2005. “Temporally regulated expression of Cre recombinase in neural stem cells.” Genesis. Vol. 41(4): 147-153. 128. Luikart, B.W., Nef, S., Virmani, T., Lush, M.E., Liu, Y., Kavalali, E.T. and Parada, L.F. 2005. “TrkB has a cell autonomous role in establishment of hippocampal Schaffer collateral synapses.” Journal of Neuroscience. Vol. 25(15): 3774-3786. 129. Lei, L., Laub, F., Lush, M., Romero, M., Zhou, J., Luikart, B., Klesse, L., Ramirez, F. and Parada, L.F. 2005. “The zinc finger transcription factor Klf7 is required for TrkA Gene expression and development of nociceptive sensory neurons.” Genes & Development. Vol. 19(11): 1354-64. PMC1142558 130. Shi, J., Parada, L.F. and Kernie, S.G. 2005. “Bax limits adult neural stem cell persistence through caspase and IP3 receptor activation.” Cell Death and Differentiation. Vol. 12: 1601-1612. 131. Verma-Kurvari, S., Nef, S. and Parada, L.F. 2005. “Hormonal regulation of male reproductive tract development.” The New York Academy of Sciences. Vol. 1061: 1-8. 132. Laub, F., Lei, L., Sumiyoshi, H., Kajimura, D., Dragomir, C., Smaldone, S., Puche, A.C., Petros, T.J., Mason, C., Parada, L.F. and Ramirez, F. 2005. “Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system.” Molecular and Cellular Biology. Vol. 25(13): 5699-711. PMC1157008 133. Lush, M.E., Ma, L. and Parada, L.F. 2005. “TrkB signaling regulates the developmental maturation of the somatosensory cortex.” International Journal of Developmental Neuroscience. Vol. 23(6): 523-536. 134. Benson, M.B., Romero, M.I., Lush, M.E., Lu, Q.R., Henkemeyer, M. and Parada, L.F. 2005. “Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth.” Proc. Natl. Acad. Sci., U.S.A. Vol. 102(30): 10694-10699. PMC1175581 135. Zhu, Y., Guignard, F., Zhao, D., Liu, L, Burns, D.K., Mason, R.P., Messing, A. and Parada, L.F. 2005. “Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.” Cancer Cell. Vol. 8(2): 119-130. PMC3024718 136. Parada, L.F., Kwon, C.H. and Zhu, Y. 2005. “Modeling neurofibromatosis type 1 tumors in the mouse for therapeutic intervention.” Cold Spring Harbor Symposia on Quantitative Biology: Molecular Approaches to Controlling Cancer”. Vol. 70: 173-176. Luis F. Parada Page 17 of 28

137. Zhu, Y., Harada, T., Liu, L., Lush, M.E., Guignard, F., Harada, C., Burns, D.K., Bajenaru, M.L., Gutmann, D.H. and Parada, L.F. 2005. “Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation.” Development. Vol. 132(24): 5577-5588. PMC2760350 138. Malkovska, I., Kernie, S.G. and Parada, L.F. 2006. “Differential expression of the four untranslated BDNF exons in the adult mouse brain.” Journal of Neuroscience Research. Vol. 83(2): 211-21. 139. Dissen, G.A., Garcia-Rudaz, M.C., Tapia, V., Parada, L.F., Hsu, S.Y. and Ojeda, S.R. 2006. “Expression of the Insulin Receptor-Related Receptor (IRR) is induced by the preovulatory HL surge of luteinizing hormone in thecal-interstitial cells of the rat ovary.” Endocrinology. Vol. 147(1): 155-65. 140. Harada, C., Harada, T., Nakamura, K., Sakai, Y., Tanaka, K. and Parada, L.F. 2006. “Effect of p75(NTR) on the regulation of naturally occurring cell death and retinal ganglion cell number in the mouse eye.” Developmental Biology. Vol. 290(1): 57-65. 141. Yue, Tao, Xian, K, Hurlock, E., Xin, M., Kernie, S.G., Parada, L.F. and Lu, Q.R. 2006. “A critical role for dorsal progenitors in cortical myelination.” Journal of Neuroscience. Vol. 26(4): 1275-80. 142. Kwon, C.H., Zhou, J., Li, Y., Kim, K.W., Hensley, L.L., Baker, S.J. and Parada, L.F. 2006. “Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations.” Genesis. Vol. 44(3): 130-135. 143. Kwon, C.H., Luikart, B.W., Powell, C.M., Zhou, J., Matheny, S.A., Zhang, W., Li, Y., Baker, S.J. and Parada, L.F. 2006. “Pten regulates neuronal arborization and social interaction in mice.” Neuron. Vol. 50(3): 377-388. 144. Tran, P.V., Akana, S.F., Malkovska, I., Dallman, M.F., Parada, L.F. and Ingraham, H.A. 2006. “Diminished hypothalamic BDNF expression and impaired VMH function are associated with reduced SF-1 gene dosage.” J Comp Neurol. Vol. 498(5): 637-48. 145. Yang, F.C., Chen, S, Clegg, T., Li, X., Morgan, T., Estwick, S.A., Yuan, J., Khalaf, W., Burgin, S., Travers, J., Parada, L.F., Ingram, D.A. and Clapp, D. W. 2006. “NF1+/- mast cells induce neurofibroma like phenotypes through secreted TGFb signaling.” Human Molecular Genetics. Vol. 15(16): 2421-37. PMC3024714 146. Lei, L., Zhou, J., Lin, L. and Parada, L.F. 2006. “Brn3a and Klf7 cooperate to control TrkA expression in sensory neurons.” Developmental Biology. Vol. 300(2): 758-69. 147. Wagner, E., Lou, T., Sakai, Y., Parada, L.F. and Drager, U.C. 2006. “Retinoic acid delineates the topography of neuronal plasticity in postnatal cerebral cortex.” Eur J. Neurosci. Vol. 24(2): 329-40. 148. Bingham, N.C., Verma-Kurvari, S., Parada, L.F. and Parker, K.L. 2006. “Development of a Steroidogenic Factor 1/Cre transgenic mouse line.” Genesis. Vol. 44(9): 419-424. 149. Elefteriou, F. Benson, M.D., Sowa, H., Starbuck, M., Liu, J., Ron, D., Parada, L.F. and Karsenty, G. 2006. “ATF4 mediation of NF1 pathology in bone reveals a nutritional basis for congenital skeletal dysplasiae”. Cell Metabolism. Vol. 4(6): 441-451. PMC2756713 150. Luikart, B.W. and Parada, L.F. 2006. “Receptor tyrosine kinase B-mediated excitatory synaptogenesis”. Prog Brain Res. Vol. 157: 15-24. 151. Kim, A., Morgan, K., Hasz, D.E., Wiesner, S.M., Lauchle, J.O., Geurts, J.L., Diers, M.D., Le, D.T., Kogan, S.C., Parada, L.F., Shannon, K. and Largaespada, D.A. 2006. “b common receptor inactivation attenuates myeloproliferative disease in NF1 mutant mice.” Blood. Vol. 109(4): 1687-91. PMC1794059 Luis F. Parada Page 18 of 28

152. Romero, M.I., Lin, L, Lush, M.E., Lei, L., Parada, L.F. and Zhu, Y. 2007. “Deletion of NF1 in neurons induces increased axon collateral branching after dorsal root injury.” Journal of Neuroscience. Vol. 27(8): 2124-34. 153. Lei, L. and Parada, L.F. 2007. “Transcriptional regulation of Trk family neurotrophic factor receptors.” Cellular and Molecular Life Sciences. Vol. 64(5): 522-32. 154. Monteggia, L.M., Luikart, B., Barrot, M., Thebold, D., Malkovska, I., Nef, S., Parada, L.F. and Nestler, E. J. 2007. “Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors.” Biol. Psychiatry. Vol. 61(2): 187-97. 155. Kolanczyk, M., Kossler, N., Kuhnisch, J., Lavitas, L., Stricker, S., Wilkening, U., Manjubala, I., Fratzl, P., Sporle, R., Herrmann, B.G., Parada, L.F., Kornak, U. and Mundlos, S. 2007. “Multiple roles for neurofibromin in skeletal development and growth.” Human Molecular Genetics. Vol. 16(8): 874-886. 156. Harada, T., Harada, C. and Parada, L.F. 2007. “Molecular regulation of visual system development: more than meets the eye.” Genes & Development. Vol. 21(4): 367-78. 157. Le, L. and Parada, L.F. 2007. “Tumor microenvironment and neurofibromatosis type I: connecting the GAPs.” Oncogene. Vol. 26(32): 4609-4616. PMC2760340 158. Cai, J., Chen Y., Cai W.H., Hurlock E.C., Wu H., Kernie S.G., Parada L.F., Lu Q.R. 2007. “A crucial role for Olig2 in white matter astrocyte development.” Development. Vol. 134(10): 1887-99. 159. Ogawa, S., Kwon, C.H., Zhou, J., Koovakkattu, D., Parada, L.F. and Sinton, C.M. 2007. “A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice.” Brain Research. Vol. 1168: 112-113. 160. Joseph, N.M., Mosher J.T., Buchstaller J., Snider P., McKeever P.E., Lim M., Conway S.J., Parada L.F., Zhu Y. 2008. “The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells.” Cancer Cell. Vol. 13(2): 129-140. PMC2566828 161. Lush, M. E., Li, Y., Kwon, C.H., Chen, J. and Parada, L.F. 2008. “Neurofibromin is required for barrel formation in the mouse somatosensory cortex.” Journal of Neuroscience. Vol. 28(7): 1580-1587. PMC2760344 162. Kwon, C.H., Zhao, D., Chen, J., Alcantara, S., Li, Y., Burns, D., Mason, R., Lee, E. Y-H., Wu, H. and Parada, L.F. 2008. “Pten haploinsufficiency accelerates formation of high grade astrocytomas.” Cancer Research. Vol. 68(9): 3286-3294. PMC2760841 163. Luikart, B.W., Zhang, W., Wayman, G.A., Kwon, C.H., Westbrook G.L. and Parada, L.F. 2008. “Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signaling.” Journal of Neuroscience. Vol. 28(27): 7006-7012. PMC3397478 164. Li, Y., Luikart, B.W., Birnbaum, S., Chen, J., Kwon, C.H., Kernie, S.G., Bassel-Duby, R. and Parada, L.F. 2008. “Trk B regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment.” Neuron. Vol. 59(3): 399-412. PMC2655199 165. Yang, F.C., Ingram, D.A., Chen, S., Zhu, Y., Yuan, J., Li, X., Yang, X, Knowles, S., Horn, W., Li, Y., Zhang, S., Yang, Y., Vakili, S., Yu, M., Burns, D., Robertson, K., Hutchins, G., Parada, L.F.*, and Clapp, D.W. 2008. “NF1-dependent tumors require a microenvironment containing Nf1+/- and c-kit dependent bone marrow.” Cell. Vol. 135(3): 437-448. (* co- corresponding author) PMC2788814 166. Cui, Y., Costa, R.M., Murphy, G.G., Elgersma, Y., Zhu, Y., Gutmann, D.H., Parada, L.F., Mody, I., and Silva, A. 2008. “Neurofibromin regulation of ERK signaling modulates GABA release and learning.” Cell. Vol. 135(3): 549-560. PMC2673196 167. Farassati, F., Pan, W., Yamoutour, F., Henke, S., Piedra, M., Frahm, S., Al-Tawil, S., Mangrum, W.I., Parada, L.F., Rabkin, S.D., Martuza, R.L. and Kurtz, A. 2008. “Ras Luis F. Parada Page 19 of 28

signaling influences permissiveness of malignant peripheral nerve sheath tumor cells to oncolytic herpes.” American Journal of Pathology. Vol. 173(6): 1861-1872. PMC2626396 168. Alcantara Llaguno, S., Chen, J., Kwon, C.-H., and Parada, L.F. 2008. “Neural and cancer stem cells in tumor suppressor mouse models of malignant astrocytoma.” Cold Spring Harbor Symposia on Quantitative Biology. Vol. 73: 421-426. 169. Parrinello, S., Noon, L.A., Harrisingh, M.C., Digby, P.W., Rosenberg, L.H., Cremona, C.A., Echave, P., Flanagan, A.M., Parada, L.F., and Lloyd, A.C. 2008. “NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F”. Genes & Development. Vol. 22(23): 3335-3348. PMC2600763 170. Alcantara Llaguno, S., Chen, J., Kwon, C.H., Jackson, E.L., Li, Y., Burns, D.K., Alvarez- Buylla, A., and Parada, L.F. 2009. “Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model”. Cancer Cell. Vol. 15(1): 45-56. PMC2650425 171. Chen, J., Kwon, C.H., Lin, L., Li, Y., Parada, L.F. 2009. “Inducible site-specific recombination in neural stem/progenitor cells.” Genesis. Vol. 47(2): 122-131. PMC2708938 172. Graham, D.L., Krishnan, V. Larson, E.B., Graham, A., Edwards, S., Batchell, R.K., Simmons, D., Gent, L.M., Berton, O., Bolanos, C.A., DiLeone, R.J., Parada, L.F., Nestler, E.J., and Self, D.W. 2009. “Tropomyosin-related Kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward.” Biological Psychiatry. Vol. 65(8): 696- 701. PMC2738869 173. Zhou, J., Blundell, J., Ogawa, S., Kwon, C.H., Zhang, W., Sinton, C., Powell, C.M., and Parada, L.F. 2009. “Pharmacological inhibition of mTORC1 suppresses anatomical, cellular and behavioral abnormalities in neural-specific Pten knock-out mice.” Journal of Neuroscience. Vol. 29(6): 1773-1783. 174. Le, L., Shipman, T., Burns, D.K., and Parada, L.F. 2009. “Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas.” Cell Stem Cell. Vol. 4(5): 454-463. PMCID: 2737469 175. Bodempudi, V., Yamoutpoor, F., Pan, W., Dudek, A.Z., Esfandyari, T., Piedra, M., Babovick-Vuksanovic, D., Woo, R.A., Mautner, V.F., Kluwe, L., Clapp, D.W., De Vries, G.H., Thomas, S.L., Kurtz, A., Parada, L.F., and Farassati, F. 2009. “RAL overactivation in malignant peripheral nerve sheath tumors.” Molecular and Cellular Biology. Vol. 29(14): 3964-3974. PMCID2704746 176. Lauchle, J., Kim, D., Le, D., Akagi, K., Crone, M., Krisman, K., Warner, K., Bonifas, J., Li, Q., Coakley, K., Diaz-Flores, E., Gorman, M., Przybranowski, S., Tran, M., Kogan, S., Roose, J., Copeland, N., Jenkins, N., Parada, L.F., Wolff, L. Sebolt-Leopold, J. and Shannon, K. 2009 “Response and resistance to MEK inhibition in leukemias initiated by hyperactive Ras.” Nature. Vol. 461(7262): 411-414. 177. Lin, L., Chen, J., Richardson, J.A., and Parada, L.F. 2009. “Mice lacking neurofibromin develop gastric hyperplasia.” American Journal of Physiology – Gastrointestinal and Liver Physiology. Vol. 297: G751-G761. PMC2763809 178. Zhou, J., Brugarolas, J., and Parada, L.F. 2009. “Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1.” Human Molecular Genetics. Vol. 18(22): 4428-4441. 179. Zhou, J. and Parada, L.F. 2009. “A motor driving PTEN.” Nature Cell Biology. Vol. 11(10): 1177-1179. Luis F. Parada Page 20 of 28

180. Choi, S.H., Li, Y. Parada, L.F., and Sisodia, S.S. 2009. “Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF". Molecular Neurodegeneration. Vol. 4(1): 52. PMC2806355 181. Gregorian, C., Nakashima, J., Dry, S., Nghiemphu, L.P., Smith, K.B., Ao, Y., Dang, J., Lawson, G., Mellinghoff, I., Mischel, P., Phelps, M., Parada, L.F., Liu, X., Sofroniw, M., Eilber, F., and Wu, H. 2009. PTEN dosage is essential for neurofibroma development and malignant transformation.” Proceedings of the National Academy of Sciences. Vol. 106(46): 19479-19484. PMC2765459 182. Pitetti, J.L., Torre, D., Conne, B., Papaioannou, M.D., Cederroth, C.R., Xuan, S., Kahn, R., Parada, L.F., Vassalli, J.D., Efstratiadis, A., and Nef, S. 2009. “Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice.” Sexual Development. Vol. 3(5): 264-272. 183. Alcantara Llaguno, S.R., Chen, J., and Parada, L.F. 2009. “Signaling in malignant astrocytomas: role of neural stem calls and its therapeutic implications.” Clinical Cancer Research. Vol. 15(23): 7124-7129. PMC2787668 184. Namekata, K., Harada, C., Taya, C., Guo, X., Kimura, H., Parada, L.F., and Harada, T. 2010. “Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.” Proceedings of the National Academy of Sciences. Vol. 107(16): 7568-7591. PMC2867726 185. Huson, S.M., Acosta, M.T., Belzberg, A.J., Bernards, A., Chernoff, J., Cichowski, K., Gareth Evans, D., Ferner, R.E., Giovannini, M., Korf, B.R., Listernick, R., North, K.N., Packer, R.J., Parada, L.F., Peltonen, J., Ramesh, V., Reilly, K.M., Risner, J.W., Schorry, E.K., Upadhyaya, M., Viskochil, D.H., Zhu, Y., Hunter-Schaedle, K., Giancotti, F.G. 2011. “Back to the future: Proceedings from the 2010 NF conference.” American Journal of Medical Genetics. Part A. 2011. Vol. 155(2): 307-321. PMC3079924 186. Alcantara Llaguno, S.R., Chen, Y., McKay, R.M. and Parada, L.F. 2011. “Stem cells in brain tumor development.” Current Topics in Developmental Biology. Vol. 94: 15-44. 187. Lim, S.K., Llaguno, S.R., McKay, R.M., and Parada, L.F. 2011. “Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models.” BMB Reports. Vol. 44(3): 158-164. NIHMSID: 465336. 188. Harada, C. Guo, X. Namekata, K., Kimura, A., Nakamura, K., Tanaka, K., Parada, L.F., and Harada, T. 2011. “Glia- and neuron-specific functions of TrkB signaling during retinal degeneration and regeneration.” Nature Communications. 2:189. PMC3105320 189. Blaiss, C.A., Yu, T.S., Zhang, G., Chen, J., Dimchev, G., Parada, L.F., Powell, C.M., and Kernie, S.G. 2011. “Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury.” Journal of Neuroscience. Vol. 31(13): 4906-4916. PMC3103868 190. Hambardzumyan, D., Parada, L.F., Holland, E.C., and Charest, A. 2011. “Genetic modeling of gliomas in mice: New tools to tackle old problems.” Glia. Vol. 59(8):1155-1168. PMC3619979 191. Le, L.Q., Shipman, T., Chen, Z., Suter, U., and Parada, L.F. 2011. “Susceptible stages in Schwann cells for NF-1 associated plexiform neurofibroma development.” Cancer Research. Vol. 71(13):4686-4695. PMC3145496 192. Luikart, B.W., Bensen, A.L., Washburn, E.K., Perederiy, J.V., Su, K.G., Kernie, S.G., Parada, L.F., and Westbrook, G.L. 2011. “miR-132 mediates the integration of newborn neurons into the adult dentate gyrus.” PLoS One. Vol. 6(5):e19077. PMC3096628 Luis F. Parada Page 21 of 28

193. Zhou, J., Shrikhande, G., Xu, J., McKay, R.M., Burns, D.K., Johnson, J.E., and Parada, L.F. 2011. “Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle.” Genes & Development. Vol. 25(15):1595- 1600. PMC3182017 194. Fassl, A., Tagscherer, K.E., Richter, J., Berriel Diaz, M., Alcantara Llaguno, S., Herold- Mende, C.C., Parada, L.F., Wiestler, O.D., and Roth, W. 2012. “Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1.” Oncogene. Vol. 31(44):4698-4708. 195. Alanne, M.H., Siljamäki, E., Peltonen, S., Väänänen, K., Windle, J.J., Parada, L.F., Määttä, J.A., and Peltonen, J. 2012. “Phenotypic characterization of transgenic mice harboring Nf1(+/-) or Nf1(-/-) osteoclasts in otherwise Nf1(+/+) background.” Journal of Cellular Biochemistry. Vol. 113(6):2136-2146. 196. Li, Y., Li, Y., McKay, R.M., Riethmacher, D., and Parada, L.F. 2012. “Neurofibromin regulation of ERK signaling modulates adult hippocampal neurogenesis and behavioral effects of antidepressants.” Journal of Neuroscience. Vol. 32(10):3529-3539. PMC3511887 197. Colombo, E., Cordiglieri, C., Melli, G., Newcombe, J., Krumbholz, M., Parada, L.F., Medico, E., Hohlfeld, R., Meinl, E., and Farina, C. 2012. “Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration.” Journal of Experimental Medicine. Vol. 209(3):521-535. PMC3302220 198. Sanchez-Ortiz, E., Yui, D., Song, D., Li, Y., Rubenstein, J.L., Reichardt, L.F., and Parada, L.F. 2012. “TrkA gene ablation in basal forebrain results in phenotypic abnormalities characteristic of Alzheimer's Disease.” Journal of Neuroscience. Vol. 32(12):4065-4079. PMC3403817 199. Chen, J., McKay, R.M., and Parada, L.F. 2012. Malignant glioma: lessons from genomics, mouse models and stem cells. Cell. Vol. 149(1):36-47. NIHMSID: 465317. 200. Borrego-Diaz, E., Terai, K., Lialyte, K., Wise, A.L., Esfandyari, T., Behbod, F., Mautner, V.F., Spyra, M., Taylor, S., Parada, L.F., Upadhyaya, M., and Farassati, F. 2012. “Overactivation of Ras signaling pathway in CD133+ MPNST cells.” Journal of Neuro- Oncology. Vol. 108(3):423-434. 201. Amiri, A., Cho, W., Zhou, J., Birnbaum, S.G., Sinton, C.M., McKay, R.M., and Parada, L.F. 2012. “Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis.” Journal of Neuroscience. Vol. 32(17):5880-5890. 202. Zhou, J. and Parada, L.F. 2012. “PTEN signaling in autism spectrum disorders.” Current Opinion in Neurobiology. Vol. 22(5):873-879. 203. Acosta, M.T., Bearden, C.E., Castellanos, X.F., Cutting, L., Elgersma, Y., Gioia, G., Gutmann, D.H., Lee, Y.S., Legius, E., Muenke, M., North, K., Parada, L.F., Ratner, N., Hunter-Schaedle, K., and Silva, A.J. 2012. “The Learning Disabilities Network (LeaDNet): Using neurofibromatosis type 1 (NF1) as a paradigm for translational research.” American Journal of Medical Genetics Part A. Vol. 158A(9): 2225-2232. 204. Chen, J., Li, Y., Yu, T-S., McKay, R.M., Burns, D.K., and Parada, L.F. 2012. “A restricted cell population propagates glioblastoma growth following chemotherapy.” Nature. Vol. 488: 522-526. PMC3427400 205. Kim. T.H., Song, J., Alcantara Llaguno, S.R., Murnan, E., Liyanarachchi, S., Palanichamy, K., Yi, J.Y., Viapiano, M.S., Nakano, I., Yoon, S.O., Wu, H., Parada, L.F., and Kwon, C.H. 2012. “Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth.” PLoS One. Vol. 7(8):e42818. PMC3419743 Luis F. Parada Page 22 of 28

206. Li, Y., Yui, D., Luikart, B.W., McKay, R.M., Li. Y., Rubenstein, J.L., and Parada, L.F. 2012. “Conditional ablation of Brain-derived Neurotrophic Factor-TrkB signaling impairs striatal neuron development.” Proceedings of the National Academy of Sciences. Vol. 109(38):15491-15496. PMC3458400 207. Gutmann, D.H., Parada, L.F., Silva, A.J., Ratner, N. 2012. “Neurofibromatosis type 1: modeling CNS dysfunction.” Journal of Neuroscience. Vol. 32(41):14087-14093. PMC3477849 208. Robertson, K.A., Nalepa, G., Yang, F.C., Bowers, D.C., Ho, C.Y., Hutchins, G.D., Croop, J.M., Vik, T.A., Denne, S.C., Parada, L.F., Hingtgen, C.M., Walsh, L.E., Yu, M., Pradhan, K.R., Edwards-Brown, M.K., Cohen, M.D., Fletcher, J.W., Travers, J.B., Staser, K.W., Lee, M.W., Sherman, M.R., Davis, C.J., Miller, L.C., Ingram, D.A., Clapp, D.W. 2012. “Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial.” Lancet Oncology. Vol. 13(12):1218-1224. 209. Mo, W., Chen, J., Patel, A., Zhang, L., Chau, V., Li, Y., Cho, W., Lim, S.K., Xu, J., Lazar, A.J., Creighton, C.J., Bolshakov, S., McKay, R.M., Lev, D., Le, L.Q., and Parada, L.F. 2013. “CXCR4 mediates autocrine cell cycle progression in NF1-associated malignant peripheral nerve sheath tumors.” Cell. Vol. 152(5):1077-1090. PMC3594500 210. Takeuchi, K., Gertner, M., Zhou, J., Parada, L.F., Bennett, M.V., and Zukin, R.S. 2013. “Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism.” Proceedings of the National Academy of Sciences. Vol. 110(12):4738-4743. PMC3607034 211. Mason, B.L., Lobo, M.K., Parada, L.F., and Lutter, M. 2013. “TrkB signaling in dopamine 1 receptor neurons regulates food intake and body weight.” Obesity. Epub ahead of print. 212. Wang, Y., Lin, L., Lai, H., Parada, L.F., and Lei, L. 2013. “Transcription factor sox11 is essential for both embryonic and adult neurogenesis.” Developmental Dynamics. Vol. 242(6):638-653. 213. Oliver, J.A., Lapinski, P.E., Lubeck, B.A., Turner, J.S., Parada, L.F., Zhu, Y., and King, P.D. 2013. “The Ras GTPase-activating protein neurofibromin 1 promotes the positive selection of thymocytes.” Molecular Immunology. Vol. 55(3-4):292-302. PMC3646930 214. Biddlestone-Thorpe, L., Sajjad, M., Rosenberg, E., Beckta, J.M., Valerie, N.C., Tokarz, M., Adams, B.R., Wagner, A.F., Khalil, A., Gilfor, D., Golding, S.E., Deb, S., Temesi, D.G., Lau, A., O’Connor, M.J., Choe, K.S., Parada, L.F., Lim, S.K., Mukhopadhyay, N., and Valerie, K. 2013. “ATM kinase inhibition preferentially sensitizes p53 mutant glioma to ionizing radiation.” Clinical Cancer Research. Vol. 19(12):3189-3200. PMC3687028 215. Nalepa, G., Barnholtz-Sloan, J., Enzor, R., Dey, D., He, Y., Gehlhausen, J.R., Lehmann, A.S., Park, S.J., Yang, Y., Yang, X., Chen, S., Guan, X., Chen, Y., Renbarger, J., Yang, F.C., Parada, L.F., Clapp, W. 2013. “The tumor suppressor CDKN3 controls mitosis.” Journal of Cell Biology. Vol. 201(7):997-1012. PMC3691455 216. Ribeiro, S., Napoli, I., White, I.J., Parrinello, S., Flanagan, A.M., Suter, U., Parada, L.F., Lloyd, A.C. 2013. “Injury signals cooperate with Nf1 loss to relieve the tumor-suppressive environment of adult nerve.” Cell Reports. Vol. 17;5(1): 126-36. 217. Haws, M.E., Jaramillo, T.C., Espinosa-Becerra, F., Widman, A., Stuber, G.D., Sparta, D.R., Tye, K.M., Russo, S.J., Parada, L.F., Kaplitt, M., Bonci, A., Powell, C.M. 2014. “PTEN knockdown alters dendritic spine/protrusion morphology, not density.” J Comp Neurol. Vol. 1;522(5): 1171-90. PMID: 24264880 Luis F. Parada Page 23 of 28

218. Amiri, A., Cho, W., Sanchez-Ortiz, E., Birnbaum, S.G., McKay, R.M., and Parada, L.F. 2014. “Analysis of Fmr1 deletion in a subpopulation of post-mitotic neurons in mouse cortex and hippocampus.” Autism Research. Vol. 7(1):60-71. PMID: 24408886 219. Chau, V., Lim, S.K., Mo, W., Liu, C., Patel, A.J., McKay, R.M., Wei, S., Posner, B.A., De Brabander, J.K., Williams, N.S., Parada L.F., Le, L.Q. 2014. “Preclinical therapeutic efficacy of a novel pharmacological inducer of apoptosis in malignant peripheral nerve sheath tumors.” Cancer Research. Vol. 74(2):586-97. (* co- corresponding author) PMID: 24285727. 220. Shi, Y., Lim, S.K., and Parada, L.F. 2014. “The soft underbelly of tumor cells.” Cell Research. Epub ahead of print. PMID: 24874955 221. Rauen KA, Huson SM, Burkitt-Wright E, Evans DG, Farschtschi S, Ferner RE, Gutmann DH, Hanemann CO, Kerr B, Legius E, Parada LF, Patton M, Peltonen J, Ratner N, Riccardi VM, van der Vaart T, Vikkula M, Viskochil DH, Zenker M, Upadhyaya M. Recent developments in neurofibromatoses and RASopathies: Management, diagnosis and current and future therapeutic avenues. Am J Med Genet. 2014 Nov 12. 222. Penzo, M., Robert, V., Tucciarone, J., Darvas, M., Huang, Z., De Bundel, D., Wang, M., Van Aeist, L., Parada, L.F., Palmiter, R., He, M., Li, B. 2015. “The paraventricular thalamus controls a central amygdala fear circuit.” Nature, 2015 Mar 26;519(7544):455- 9. 223. Sanchez-Ortiz, E., Cho, W., Mo, W., Chen, J., and Parada, L.F. 2014. “NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development.” Genes and Development. Vol. 28(21):2407- 20. PMCID: PMC4215185. 224. Lubeck B.A., Lapinski P.E., Oliver J.A., Ksionda O., Parada L.F., Zhu Y., Maillard I., Chiang M., Roose J., King PD.J Immunol. 2015 Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.Jul 1;195(1):31- 5. 225. Zong, H., Parada, L.F., Baker S.J. 2015. Cell of origin for malignant gliomas and its implication in therapeutic development. Cold Spring Harb Perspect Biol. Jan 29;7(5) 226. Alcantara Llaguno, S.R., Wang, Z., Sun, D., Chen, J., Kim, E., Xu, J., Hatanpaa, K.J., Raisanen, J.M., Burns, D.K., Johnson, J.E., and Parada, L.F. 2015. "Adult Lineage Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes.” Cancer Cell. Vol. 28(4):429-40. PMCID: PMC4607935. 227. Alcantara Llaguno, S.R., Xie X., Parada, L.F. Cell of Origin and Cancer Stem Cells in Tumor Suppressor Mouse Models of Glioblastoma. Cold Spring Harb Symp Quant Biol. 2016 Nov 4. pii: 030973. [Epub ahead of print] PubMed PMID: 27815542. 228. Alcantara Llaguno, S.R., Parada, L.F. Cell of origin of glioma: biological and clinical implications. Br J Cancer. 2016 Dec 6;115(12):1445-1450. PMCID: PMC5155355. 229. Ma, Z., Zang, T., Birnbaum S.G., Wang, Z., Johnson J.E., Zhang, C.L., Parada, L.F. TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response. Nature Communications. 2017 Nov. 21; 8: 1668. PMID: 29162814 230. Parada, L.F., Dirks, P., Wechsler-Reya R.J. Brain Tumor Stem Cells Remain in Play. J Clin Oncol. 2017 Jul 20; 35(21):2428-2431. PMCID: PMC5516484. 231. Alcantara Llaguno, S.R., Sun, D., Vera, E., Pedraza A., Wang, Z., Burns D.K., Parada, L.F. Cell-of-origin Susceptibility to Glioblastoma Formation Declines with Neural Luis F. Parada Page 24 of 28

Lineage Restriction. Nature Neuroscience. 2019 Apr; 22(4):545-555. PMID: 30778149 232. Shi, Y., Lim. S.K., Liang, Q., Iyer, S., Wang, H., Wang, Z., Xie, X., Chen, Y., Tabar, V., Gutin, P., Williams, N., De Brabander, J.K., Parada, L.F. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019 Mar; 567(7748):341- 346. PMID: 30842654 233. Wang Z, Sun D, Chen YJ, Xie X, Shi Y, Tabar V, Brennan CW, Bale TA, Jayewickreme CD, Laks DR, Alcantara Llaguno S, Parada L.F. Cell Lineage-Based Stratification for Glioblastoma. Cancer Cell. 2020 Jun 23; S1535-6108(20)30307-X. PMID: 32649888 234. Xie XP, Laks DR, Sun D, Poran A, Laughney AM, Wang Z, Sam J, Belenguer G, Fariñas I, Elemento O, Zhou X, Parada LF. High-resolution mouse subventricular zone stem- cell niche transcriptome reveals features of lineage, anatomy, and aging. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31448-31458. doi: 10.1073/pnas.2014389117. Epub 2020 Nov 23. PMID: 33229571 235. Qin, Y, Wong, B., Geng, F., Zhong, L., Parada L.F., Wen, D. Generation of transgender female clonal mice via CRISPR/Cas9-mediated Y chromosome deletion in male embryonic stem cells. The CRISPR Journal. Epub 2021 Feb 9; (1):147-154. PMCID: 7898403 236. Sun, D, Xie X, Wang, Z, Sait, S, Iyer, S, Chen, Y, Brown, R, Laks, DR, Chipman, M, Parada L.F. Stem-like cells drive NF1-associated MPNST heterogeneity and relapse after chemotherapy. Cell Stem Cell. 2021. Published. 237. Mellinghoff, I, Veronica Nagle, V, Hertz, C, Campos, C, Parada, L.F., Schietinger, S. Imaging Tumor-Infiltrating Lymphocytes in Glioblastoma with [64Cu] Cu-NOTA-anti- CD8-Positron Emission Tomography. Clinical Cancer Research. PMCID: PMC8026513 238. Euido Nishijima; Yuta Kitamura; Sari Honda; Kazuhiko Namekata; Atsuko Kimura; Xiaoli Guo; Yuriko Azuchi; Chikako Harada; Tadashi Nakano; Luis F. Parada; Takayuki Harada, M.D., Ph.D. Robust Signaling Downstream of Trk Receptors Confers Neuroprotection and Enhanced Regeneration in Retinal Ganglion Neurons. 2021 Feb 1. Submitted. 239. Xie Xuanhua, Laks Dan R., Sun, Daochun, Wang, Zilai, Bale Tejus A., Tabar, Viviane, Brennan Cameron W., Zhou, Xiuping, Parada Luis. F. A quiescent human glioblastoma stem cell gene expression signature. Cancer Cell. 2020. Submitted.

Selected Invited Presentations

2013 • Targeting Cancer Stem Cells Symposium, San Francisco, CA. February 11-12, 2013. • Keystone Symposia: Stem Cell Regulation in Homeostasis and Disease, Banff, Alberta, Canada, February 24-March 1, 2013. • Indiana University Seminar Series, Indianapolis, IN. March 6 – 7, 2013. • Dartmouth University Seminar Series, Lebanon, N.H. March 12 – 14, 2013. • Johns Hopkins Seminar Series, Baltimore, MD. May 2, 2013. • Blaffer Lecture: MD Anderson Cancer Center, Houston, TX. May 14, 2013. • American Society for Neuroradiology, San Diego, CA. May 17 – 18, 2013. • Children's Tumor Foundation Annual Conference, "What's new…?" Monterey, CA. June 8 – 11, 2013. • Next Frontiers to Cure Cancer - Integrating Science and Patient Care, Sao Paulo, Brazil, June 13 Luis F. Parada Page 25 of 28

– 15, 2013. • The European Cancer Stem Cell Research Institute Targeting Cancer Conference, Cardiff, U.K. July 24-26, 2013. • REDLANO CONGRESSO 2013, “Related Therapeutic Prospects Stems Cells in Gliomas.” Cartagena, Colombia. August 2-3, 2013 • UT Arlington – Center of Excellence for the Study of Health & Chronic Illnesses, “New Frontiers in Brain Cancer Research.” Arlington, TX. September 4, 2013. • ISREC Distinguished Lectures in Cancer Research, Lausanne, Switzerland. September 10-14, 2013. • AACR 3rd International Conference, National Harbor, MD. September 20, 2013. • Institut du Cerveau et de la Moelle Epeniere, Paris, France. September 22-25, 2013. • Recent Developments in Neurofibromatosis & Rasopathies, Cardiff, Wales, U.K. September 30, 2013. • Novartis Institutes for Bio Medical Research Seminar, Cambridge, MA. October 7, 2013. • Shanghai International Symposium on Cancer Stem Cells, Shanghai, China. October 17-19, 2013. • 20th Annual Prostate Cancer Foundation Scientific Retreat, National Harbor, MD. October 24, 2013. • Nature – CNIO Cancer Symposium – Frontiers in Tumor Heterogeneity and Plasticity, Madrid, Spain. October 27-30, 2013. • Frontiers in Cancer Science Committee Annual Cancer Conference. Singapore November 5-8, 2013. • The Epithelial-Mesenchymal Transition International Association (TEMTIA Neural Tumors: Alicante, Spain. November 13-16, 2013.

2014 • 2014 Miami Winter Symposium Miami, Florida. January 26-29, 2014. • Keystone Symposium: Stem Cells and Cancer. Banff, Alberta Canada. February 2-5, 2014. • Sylvester Comprehensive Cancer Center. Miami, FL. February 20-21, 2014. • AACR Special Conference—Cellular Heterogeneity in the Tumor Environment. San Diego, CA. February 26 – March 1, 2014. • Baylor College of Medicine. Houston, TX. March 4-5, 2014. • 1st International Kloster Seeon Meeting. Seeon Monastery, Germany. March 8 – 11, 2014 • Joint Meeting – British Society of Cell Biology & Developmental Biology. Coventry, UK. March 16-19, 2014. • University of New Mexico Annual Neuroscience Day. Keynote Lecture. Albuquerque, NM. March 20-21, 2014. • AACR Annual Meeting. San Diego, CA. April 5 – 10, 2014. • EMBO-EMBL Symposium Heidelberg, Germany. May 7-10, 2014. • Einstein College of Medicine. Cancer Stem Cell Symposium. Bronx, NY. May 13-14, 2014. • 2014 Children’s Tumor Foundation Conference. Washington, DC. June 7 – 10, 2014. • International Society for Stem Cell Research 12th Annual Meeting. Vancouver, Canada. June 18 – 21, 2014. • Brain Tumors 2014 – From Biology to Therapy. Keynote lecture –Warsaw, Poland. June 26 – 28, 2014. • Cold Spring Harbor Laboratory – Mechanisms & Models of Cancer 2014. Cold Spring Harbor, Luis F. Parada Page 26 of 28

NY. August 12 – 16, 2014 • Cleveland Cancer Stem Cell Conference. Cleveland, OH. August 17 – 20, 2014. • Georgetown University, Lombardi Comprehensive Cancer Center Visiting Professorship Seminar Series. Washington, DC. September 19, 2014. • 8th International Heinrich F.C. Behr Symposium – Stem Cells and Cancer. Heidelberg, Germany. September 28 – 30, 2014. • EMBO Workshop – Cancer stem cells 20 years later: Achievements, controversies, emerging concepts and technologies. Catanzaro, Italy. October 3 – 6, 2014. • AACR New Horizons in Cancer Research Conference. “Where lies the heterogeneity in GBM.” Shanghai, China. October 9 – 12, 2014. • The Herman Vanden Berghe Lecture Series, Department of Human Genetics. 1st lecture: “Von Recklinghausens Neurofibromatosis: of mice and men.” 2nd lecture: “Glioblastoma, cancer stem cells and beyond.” University of Leuven, Leuven, Belgium. October 19 – 23, 2014.

2015 • Moore Cancer Center Director’s Seminar. San Diego, CA. February 11, 2015. • Stem Cells & Cancer Gordon Research Conference. Ventura, CA. February 15 – 20, 2015. • Cancer Gene Symposium. Hong Kong. March 12 – 14, 2015. • International Gliomatosis Cerebri Meeting. Paris, France. March 26 – 27, 2015. • MSKCC Beene Cancer Center Retreat. Hamburg, NJ. April 30 – May 1, 2015. • 2015 Children Tumor Foundation’s Neurofibromatosis Conference. Monterey, CA. June 6 - 9, • University of Texas M.D. Anderson Cancer Center Distinguished Lectureship in Cancer Biology. Houston, TX. June 25 – 26, 2015. • 8th Annual Beth Israel Deaconess Medical Center Cancer Symposium. “Glioma Stem Cells: A new therapy target.” Boston, MA. October 13, 2015. • St. Jude 11th Annual Biomedical Research Symposium on ‘Stem Cells in Cancer.’ “Glioma Stem Cells: What are they?” Memphis, TN. October 23, 2015. • COBRE EAC Meeting. Columbia, SC. October 27, 2015. • AACR Special Conference on Pediatric Cancer. “Glioma Stem Cells: What are they?” Ft. Lauderdale, FL. November 9 – 12, 2015. • AACR Special Conference on Developmental Biology and Cancer. “The effect of cell of origin on GBM phenotype.” Boston, MA. November 30 – December 3, 2015.

2016 • EMBO | EMBL Symposium: Tumour Microenvironment and Signaling. Heidelberg, Germany. April 2 – 6, 2016. • AACR Annual Meeting. New Orleans, LA. April 16 – 20, 2016. • 81st Cold Spring Harbor Laboratory Symposium on Quantitative Biology addressing Targeting Cancer. June 1 – 5, 2016. • 2016 Cancer Stem Cells Conference. Cleveland, OH. September 20 – 22, 2016. • Fox Chase Center, Cancer Biology Program. October 16, 2016. • Genentech, Department of Physiological Chemistry. October 14, 2016. • AACR New Horizons in Cancer Research. Shanghai, China. November 1 – 7, 2016. • SNO Annual Meeting. Scottsdale, AZ. November 17 – 21, 2016. Luis F. Parada Page 27 of 28

2017

• NY Cancer Genomics Research. New York, NY. February 7, 2017. • CNIO Frontier Meeting 2017 on Primary and Secondary Brain Tumors. Madrid, Spain. February 19 – 22, 2017. • Cornell- Tri-Institutional Research Lunch. New York, NY. March 3, 2017 • Gwangju Institute of Science and Technology. Gwangju, South Korea. March 14, 2017. • KAIST - Korea Advanced Institute of Science & Technology. Daejeon, South Korea. March 15, 2017. • Severance Hospital, Yonsei University College of Medicine. Seoul, South Korea. March 16, 2017. • 2017 Annual Meeting of KSNO. Seoul, South Korea. March 18, 2017. • Albert Einstein College of Medicine/Montefiore Medical Center Neurology Grand Rounds. New York, NY. March 23, 2017. • Winship Cancer Institute at Emory University CCB Program Seminar. Atlanta, GA. April 6th, 2017. • 2017 Herbert Irving Comprehensive Cancer Center Annual Symposium, Columbia University. New York, NY. April 10, 2017. • Abramson Family Cancer Research Institute and the Department of Hematology/Oncology at the University of Pennsylvania. Philadelphia, PA. April 18, 2017. • Stanford Stem Cell Institute Seminar Series. Stanford, CA. April 27, 2017. • ISSCR 2017 Annual Meeting. Boston, MA. June 14 – 17, 2017. • Frederick National Laboratory Lecture. Washington, DC. September 15, 2017. • AACR Special Conference entitled Advances in Modeling Cancer in Mice. Orlando, FL. September 24 – 30, 2017. • Anderson Center for Cancer Research Lecture at The Rockefeller University. New York, NY October 5th, 2017. • New Developments in Neurofibromatosis and RASopathies: Their management, diagnosis and therapeutic targets. Kerala, India. November 27th – 29th, 2017.

2018 • Mass General Cancer Center Grand Rounds. Boston, MA. February 1st, 2018. • Genomics of MPNST Consortium Dinner. Boston, MA. April 22, 2018. • Cancer Research UK Brain Tumour Conference. London, UK. May 1st – 3rd, 2018. • Frontiers in Stem Cells in Cancer (FriSC2). New Orleans, LA. May 7th – 8th, 2018 • Sue & Bill Gross Stem Cell Research Center Seminar Series. UCI Irvine. Irvine, CA. May 11th, 2018. • The 4th Brain Tumors 2018: From Biology to Therapy Conference. Nencki Institute. “The role of cell of origin and cancer stem cells in GBM phenotype.” Warsaw, Poland. June 21st – 23rd, 2018. • 2018 Joint Global Neurofibromatosis Conference. Paris, France. November 2 – 6, 2018.

2019 • The Banbury Center – CSHL. “Glioblastoma: Why is impactful science so hard to translate?” New York. April 7-10, 2019. Luis F. Parada Page 28 of 28

• Moffitt Cancer Center. Tampa, FL. May 21-23, 2019. • International Symposium: Advances in Cancer Stem Cell Therapeutics. “Hierarchical Growth in Glioblastoma: Therapeutic Insights.” Zhengzhou, China. August 24-25, 2019. • NF Conference/Children’s Tumor Foundation. “Malignant Peripheral Nerve Sheath Tumors: From Beginning to End.” San Francisco, CA. September 21-24,2019. • CSHL Stem Cell Biology Symposium. NY. September 21, 2019. • CSCI Columbia Stem Cell Initiative Seminar. “A Quiescent Glioblastoma Stem Cell” NYC. November 7, 2019. • Society for Neuro-Oncology 24th Annual Meeting. “Stem cell biology and the mechanisms of glioma resistance.” Phoenix, AZ. November 20-24, 2019.

2020 • Littlest Tumor Foundation/Congressional Briefing. “Value of Federal Investment in NF Research.” Washington, DC. January 10, 2020. • Cancer & Metastasis Conference. University of Westminster. “Stem cell biology and the mechanisms of glioma resistance.” Virtual. June 30, 2020. • Bristol-Myers Squibb GBM RoundTable. “Glioma Stem Cells: Origin and Molecular Features” Virtual. July 7-8, 2020. • MD Anderson BTC Distinguished Lecture Series. “Stem cell biology and the mechanisms of glioma resistance.” Texas. Fall, 2020. • American Brain Tumor Association Alumni Research Network. “Cell of origin: New targets for inhibiting glioblastoma” Virtual. September 9-11, 2020. • European NF2020 Conference. “Stem-like cells drive hierarchical growth in MPNST”. Virtual. December 10-13, 2020.

2021

• Whitehead Institute Forum.” Quiescent Glioma Stem Cells”. Virtual. April 23rd, 2021. • CSHL-Defeating Cancer Lecture. “Glioma Stem Cells: Origin and Molecular Features” Virtual. April 26th, 2021.