Anais 41CBO(Ing).Indb 1 21/12/2011 15:02:32 Oral Presentation
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Anais_41CBO(ing).indb 1 21/12/2011 15:02:32 Oral Presentation 10 to 14 days interval (r=0.72). Surgery effect size was 1.55. The minimally OP-01 SGP: 7754 important difference was 14 points and scores up to 10 points were consi- dered normal. Conclusion: the Brazilian Portuguese SNOT-22 version is a Invasive fungal rhinosinusitis: neutropenia as a predictive and valid instrument to assess chronic rhinosinusitis and nasal polyps patients. prognostic feature Author(s): Erica Ortiz, Eder Barbosa Muranaka, Eulalia Sakano Keywords: fungi, neutropenia, sinusitis. OP-03 SGP: 8254 Introduction: Invasive fungal rhinosinusitis has a disastrous and rapid clini- Correlation between chemokine gene expression and eosinophilia cal course with a high mortality rate (60-90%), mainly in immunosuppressed in eosinophilic nasal polyps patients.According to the literature, the severity and extent of neutropenia Author(s): Fransergio Emilio Mantovani Cavallari, Rafael Rossell Malinsky, is the major risk factor for invasive fungal infection (count <500/dl). Ob- Siomara Bambirra de Oliveira, Aline Jorge Gallego, Fabiana Cardoso Pereira jective: To investigate the predictive and prognostic value of neutropenia Valera, Edwin Tamashiro, Cristiane Milanezi, Francesca Maia Faria, João Santana concerning the occurrence of invasive fungal rhinosinusitis. Methods: We da Silva, Wilma Terezinha Anselmo Lima studied 18 immunosuppressed patients with invasive fungal rhinosinusitis and 17 immunocompetent patients with non-invasive fungal rhinosinusitis as Keywords: chemokines, cytokines, eosinophilia, gene expression, nasal polyps. a control group. The variables evaluated were serum counts of neutrophils, Nasal polyposis(NP) is a inflammatory disease of the nasal mucosa, mostly lymphocytes and leukocytes; type of fungus; nasopharyngoscopy; type of related to eosinophilia; and its pathophysiology is not yet clear. Today, there treatment and survival. Results: Invasive fungal rhinosinusitis occurred only is an increasing number of cytokines, chemokines, adesin molecules and in immunosuppressed patients, the characteristics found in invasive fungal their receptors being studied in this disease. Objectives: to compare the rhinosinusitis were necrosis in the nasal cavity; homogenous opacification gene expression of RANTES and eotaxin-2 chemokines, their receptors, CCR3, and signs of bone erosion on the CT scan; the fusarium fungus as the most cytokine IL5, adesin molecule ICAM-1 and its LFA-1 receptor in eosinophilic prevalent fungus; a higher frequency of death especially in young patients polyps and normal nasal mucosa as controls and to establish a correlation (27yo). The lymphocyte count was lower in invasive fungal rhinosinusitis, between quantitative eosinophilia and the gene expression of mediators and death was associated with lower counts of leukocytes and lymphocytes. in nasal polyps. Methods: we quantified the gene expression through the In logistic regression analysis, patients with the highest risk of death are RT-PCR technique in polyps and healthy nasal mucosa and quantified the those with less leukocytes (OR = 2:44, 95% CI 1.11, 5.38). Conclusion: eosinophilia by means of light microscopy. Results: we found elevated Unlike the literature, this study suggests that invasive fungal rhinosinusitis expression of eotaxin-2, RANTES and IL5 in NPs, and a direct correlation was related to lower lymphocyte count, and death occurred more frequently between quantitative eosinophilia and gene expression of eotaxin-2 and in patients with leukopenia. Studies with larger sample sizes may clarify CCR3. Such data stresses the importance of chemokines and their receptors these relationships. in eosinophilia-related NPs. OP-02 SGP: 7924 OP-04 SGP: 8394 Translation, cross-cultural adaptation and validation of the 22-item Sinonasal disease assessment in pre-bone marrow transplantation Sinonasal Outcome Test Questionnaire for Brazilian Portuguese patients Author(s): Eduardo Macoto Kosugi, Vitor Guo Chen, Viviane Maria Guerreiro Author(s): Rafael Panizza Leutz, Michelle Fantin Yakabe, Adriano Guirado Dias, da Fonseca, Milena Martins Pellogia Cursino, José Arruda Mendes Neto, Luís Rael Lucas Matimoto, Atilio Maximino Fernandes, Erika Rodrigues Pontes Carlos Gregório Delattre Keywords: nasal polyps, natural orifice endoscopic surgery, quality of life, questionnaires, sinusitis. Keywords: bone marrow transplantation, CT scan, sinusitis.. Introduction: Quality of life questionnaires have been increasingly used Bone marrow transplantation has been increasingly performed in Brazil in clinical trials to determine the impact of medical intervention or to as- and one of the most important reasons for their failure are opportunistic sess the outcome of health care services. Among disease specific outcome infections that occur due to immunosuppression. Rhinosinusitis is one of measures, SNOT-22 was considered the most suitable tool for assessing the most prevalent illnesses in transplant patients, ranging from 1 to 33% in chronic rhinosinusitis and nasal polyps patients. Aim: to perform the trans- bone marrow transplants. The screening of sinonasal pathologies pre BMT lation, cross-cultural adaptation and validation of the SNOT-22 to Brazilian remains controversial, mainly concerning CT scan. Objective: The objec- Portuguese. Methods: Eighty-nine patients with chronic rhinosinusitis or tive of this study is to assess the best means to evaluate of sinus pre BMT. nasal polyps submitted to functional endoscopic sinus surgery answered the Method: A prospective study in which patients undergo clinical evaluation, questionnaire at pre and postoperative times. Furthermore, 113 volunteers endoscopy and CT scan before being submitted to BMT. Results: Only without sinonasal disease answered the questionnaire too. Internal consis- 8.3% of the patients had sinusitis before the BMT and the diagnosis did not tency, test-retest reliability, validity of measures, responsiveness and clinical require a CT scan. There were no cases of sinusitis complication after BMT interpretability were assessed. Results: the mean preoperative, postoperative and no action was taken based on pre BMT tomography. Conclusion: and no sinonasal disease scores were, respectively, 62.39, 23.09 and 11.42 Initial results suggest that clinical evaluation and endoscopy performed by points (p < 0.0001), showing validity and responsiveness. Internal consis- otolaryngologists is the best strategy to evaluate sinus disease before BMT, tency was high (Cronbach’s alpha = 0.9276). Reproducibility was sufficient thus eliminating the need for CT scan. both in inter-interviewer use (r=0.81) as in intra-interviewer use, within a 1 Anais_41CBO(ing).indb 1 21/12/2011 15:02:32 a single reference centre via the middle cranial fossa approach (MCFA) or OP-05 SGP: 8590 the retrosigmoid approach (RSA), between January of 1988 and December of 2008. Results: During this period, 90 patients underwent MCFA, while 86 Upper Respiratory Infections: Evaluation of Risk Factors and patients were operated via the RSA. Of the patients subjected to the MCFA, Managment 80.7% were classified as House-Brackmann (HB) grade I-II after surgery, Author(s): Rodrigo Nishihara Jorge, Ricardo Landini Lutaif Dolci, Ana Carolina whereas 96.5% percent of the patients submitted to RSA were classified as Cassanti, Felipe Pinho, José Eduardo Lutaif Dolci HB grade I-II after surgery (p = 0.001). This difference was shown only for Keywords: epidemiology, respiratory tract infections, risk factors. tumors outside the meatus when we compared size-matching tumors (58.3% MCFA versus 98% RSA; p = 0.0006). There was no statistically significant URIs are frequent and most are viral-related; and they have numerous risk difference in the hearing outcomes considering hearing preservation vis-à-vis factors. There are discrepancies among papers concerning theses factors classes A and B of the Sanna classification (18.9% MCFA versus 10.6% RSA; and URI management. Our objective was to analyze these factors and p = 0.122). Conclusion: No statistically significant difference in hearing the management strategies used by Brazilian ENTs. Thus, our study was preservation was identified in comparing tumors operated upon via the prospective, epidemiological, multicentric and observational in which we MCFA versus the RSA. Our results indicate that a higher risk of facial nerve sent questionnaires the doctors. We found a high prevalence of bacterial function impairment exists if the surgery is performed via the MCFA when infections, allergic rhinitis associated with rhinosinusitis. and a positive the tumor extends to the cerebellopontine angle. influence of anti-pneumococcal vaccination associated with a reduction in the prevalence of tonsillitis. Other diseases, such as suppurative otitis and otitis externa were more common among less educated people. We could OP-08 SGP: 8157 also notice a very frequent use of steroids and antibiotics. Therefore we confirmed some already established risk factors and how frequent antibiotics Middle Ear Mucosa and Biofilm Formation study in Chronic Oti- and corticosteroids are prescribed. tis Media (COM) Author(s): Matheus de Souza Campos, Eduardo Tanaka Massuda, Miguel OP-06 SGP: 8146 Angelo Hyppolito Keywords: biofilms, otitis media, scanning electron microscopy. The influence of diabetes mellitus on cochlear electrophysiology Chronic otitis media is characterized by an inflammatory process in the mi- Author(s): Ariane Solci Bonucci, Milton Cesar Foss, Maria Cristina