CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Blood and lymphatic system disorders BL101 Anemia Blood and lymphatic system disorders BL999 Blood and lymphatic system disorders - Other, specify Blood and lymphatic system disorders BL102 Bone marrow hypocellular Blood and lymphatic system disorders BL103 Disseminated intravascular coagulation Blood and lymphatic system disorders BL104 Febrile neutropenia Blood and lymphatic system disorders BL105 Hemolysis Blood and lymphatic system disorders BL106 Hemolytic uremic syndrome Blood and lymphatic system disorders BL107 Blood and lymphatic system disorders BL108 Lymph node pain Blood and lymphatic system disorders BL109 Spleen disorder Blood and lymphatic system disorders BL110 Thrombotic thrombocytopenic purpura Cardiac disorders CA101 Acute coronary syndrome Cardiac disorders CA102 Aortic valve disease Cardiac disorders CA103 Asystole Cardiac disorders CA104 Atrial fibrillation Cardiac disorders CA105 Atrial flutter Cardiac disorders CA106 Atrioventricular block complete Cardiac disorders CA107 Atrioventricular block first degree Cardiac disorders CA108 Cardiac disorders CA999 Cardiac disorders - Other, specify Cardiac disorders CA109 Chest pain - cardiac Cardiac disorders CA110 Conduction disorder Cardiac disorders CA111 Constrictive pericarditis Cardiac disorders CA112 Heart failure Cardiac disorders CA113 Left ventricular systolic dysfunction Cardiac disorders CA114 Mitral valve disease Cardiac disorders CA115 Mobitz (type) II atrioventricular block Cardiac disorders CA116 Mobitz type I Cardiac disorders CA117 Myocardial infarction Cardiac disorders CA118 Myocarditis Cardiac disorders CA119 Palpitations Cardiac disorders CA120 Paroxysmal atrial tachycardia Cardiac disorders CA121 Pericardial effusion Cardiac disorders CA122 Pericardial tamponade Cardiac disorders CA123 Pericarditis Cardiac disorders CA124 Pulmonary valve disease Cardiac disorders CA125 Restrictive cardiomyopathy Cardiac disorders CA126 Right ventricular dysfunction Cardiac disorders CA127 Sick sinus syndrome Cardiac disorders CA128 Sinus bradycardia Cardiac disorders CA129 Sinus tachycardia Cardiac disorders CA130 Supraventricular tachycardia Cardiac disorders CA131 Tricuspid valve disease Cardiac disorders CA132 Ventricular Cardiac disorders CA133 Ventricular fibrillation Cardiac disorders CA134 Ventricular tachycardia Cardiac disorders CA135 Wolff-Parkinson-White syndrome Congenital, familial and genetic disorders FG999 Congenital, familial and genetic disorders - Other, specify

Page 1 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Ear and labyrinth disorders AU999 Ear and labyrinth disorders - Other, specify Ear and labyrinth disorders AU101 Ear pain Ear and labyrinth disorders AU102 External ear Ear and labyrinth disorders AU103 External ear pain Ear and labyrinth disorders AU104 Hearing impaired Ear and labyrinth disorders AU105 Middle ear inflammation Ear and labyrinth disorders AU106 Tinnitus Ear and labyrinth disorders AU107 Vertigo Ear and labyrinth disorders AU108 Vestibular disorder Endocrine disorders EN101 Adrenal insufficiency Endocrine disorders EN102 Cushingoid Endocrine disorders EN103 Delayed puberty Endocrine disorders EN999 Endocrine disorders - Other, specify Endocrine disorders EN104 Growth accelerated Endocrine disorders EN105 Hyperparathyroidism Endocrine disorders EN106 Hyperthyroidism Endocrine disorders EN107 Hypoparathyroidism Endocrine disorders EN108 Hypothyroidism Endocrine disorders EN109 Precocious puberty Endocrine disorders EN110 Virilization Eye disorders OC101 Blurred vision Eye disorders OC102 Cataract Eye disorders OC103 Conjunctivitis Eye disorders OC104 Corneal ulcer Eye disorders OC105 Dry eye Eye disorders OC106 Extraocular muscle paresis Eye disorders OC999 Eye disorders - Other, specify Eye disorders OC107 Eye pain Eye disorders OC108 Eyelid function disorder Eye disorders OC109 Flashing lights Eye disorders OC110 Floaters Eye disorders OC111 Glaucoma Eye disorders OC112 Keratitis Eye disorders OC113 Night blindness Eye disorders OC114 Optic nerve disorder Eye disorders OC115 Papilledema Eye disorders OC116 Photophobia Eye disorders OC117 Retinal detachment Eye disorders OC118 Retinal tear Eye disorders OC119 Retinal vascular disorder Eye disorders OC120 Retinopathy Eye disorders OC121 Scleral disorder Eye disorders OC122 Uveitis Eye disorders OC123 Vitreous hemorrhage Eye disorders OC124 Watering eyes Gastrointestinal disorders GI101 Abdominal distension Gastrointestinal disorders GI102 Abdominal pain Gastrointestinal disorders GI103 Anal fistula

Page 2 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Gastrointestinal disorders GI104 Anal hemorrhage Gastrointestinal disorders GI105 Anal mucositis Gastrointestinal disorders GI106 Anal necrosis Gastrointestinal disorders GI107 Anal pain Gastrointestinal disorders GI108 Anal Gastrointestinal disorders GI109 Anal ulcer Gastrointestinal disorders GI110 Ascites Gastrointestinal disorders GI111 Bloating Gastrointestinal disorders GI112 Cecal hemorrhage Gastrointestinal disorders GI113 Gastrointestinal disorders GI114 Colitis Gastrointestinal disorders GI115 Colonic fistula Gastrointestinal disorders GI116 Colonic hemorrhage Gastrointestinal disorders GI117 Colonic obstruction Gastrointestinal disorders GI118 Colonic perforation Gastrointestinal disorders GI119 Colonic stenosis Gastrointestinal disorders GI120 Colonic ulcer Gastrointestinal disorders GI121 Constipation Gastrointestinal disorders GI122 Dental caries Gastrointestinal disorders GI123 Diarrhea Gastrointestinal disorders GI124 Dry mouth Gastrointestinal disorders GI125 Duodenal fistula Gastrointestinal disorders GI126 Duodenal hemorrhage Gastrointestinal disorders GI127 Duodenal obstruction Gastrointestinal disorders GI128 Duodenal perforation Gastrointestinal disorders GI129 Duodenal stenosis Gastrointestinal disorders GI130 Duodenal ulcer Gastrointestinal disorders GI131 Dyspepsia Gastrointestinal disorders GI132 Dysphagia Gastrointestinal disorders GI133 Enterocolitis Gastrointestinal disorders GI134 Enterovesical fistula Gastrointestinal disorders GI135 Esophageal fistula Gastrointestinal disorders GI136 Esophageal hemorrhage Gastrointestinal disorders GI137 Esophageal necrosis Gastrointestinal disorders GI138 Esophageal obstruction Gastrointestinal disorders GI139 Esophageal pain Gastrointestinal disorders GI140 Esophageal perforation Gastrointestinal disorders GI141 Esophageal stenosis Gastrointestinal disorders GI142 Esophageal ulcer Gastrointestinal disorders GI143 hemorrhage Gastrointestinal disorders GI144 Esophagitis Gastrointestinal disorders GI145 Fecal incontinence Gastrointestinal disorders GI146 Flatulence Gastrointestinal disorders GI147 Gastric fistula Gastrointestinal disorders GI148 Gastric hemorrhage Gastrointestinal disorders GI149 Gastric necrosis Gastrointestinal disorders GI150 Gastric perforation Gastrointestinal disorders GI151 Gastric stenosis

Page 3 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Gastrointestinal disorders GI152 Gastric ulcer Gastrointestinal disorders GI153 Gastritis Gastrointestinal disorders GI154 Gastroesophageal reflux disease Gastrointestinal disorders GI999 Gastrointestinal disorders - Other, specify Gastrointestinal disorders GI155 Gastrointestinal fistula Gastrointestinal disorders GI156 Gastrointestinal pain Gastrointestinal disorders GI157 Gastroparesis Gastrointestinal disorders GI158 Gingival pain Gastrointestinal disorders GI159 Hemorrhoidal hemorrhage Gastrointestinal disorders GI160 Gastrointestinal disorders GI161 Ileal fistula Gastrointestinal disorders GI162 Ileal hemorrhage Gastrointestinal disorders GI163 Ileal obstruction Gastrointestinal disorders GI164 Ileal perforation Gastrointestinal disorders GI165 Ileal stenosis Gastrointestinal disorders GI166 Ileal ulcer Gastrointestinal disorders GI167 Ileus Gastrointestinal disorders GI168 Intra-abdominal hemorrhage Gastrointestinal disorders GI169 Jejunal fistula Gastrointestinal disorders GI170 Jejunal hemorrhage Gastrointestinal disorders GI171 Jejunal obstruction Gastrointestinal disorders GI172 Jejunal perforation Gastrointestinal disorders GI173 Jejunal stenosis Gastrointestinal disorders GI174 Jejunal ulcer Gastrointestinal disorders GI175 pain Gastrointestinal disorders GI176 Lower gastrointestinal hemorrhage Gastrointestinal disorders GI177 Malabsorption Gastrointestinal disorders GI178 Mucositis oral Gastrointestinal disorders GI179 Nausea Gastrointestinal disorders GI180 Obstruction gastric Gastrointestinal disorders GI181 Oral cavity fistula Gastrointestinal disorders GI182 Oral dysesthesia Gastrointestinal disorders GI183 Oral hemorrhage Gastrointestinal disorders GI184 Oral pain Gastrointestinal disorders GI185 Pancreatic duct stenosis Gastrointestinal disorders GI186 Pancreatic fistula Gastrointestinal disorders GI187 Pancreatic hemorrhage Gastrointestinal disorders GI188 Pancreatic necrosis Gastrointestinal disorders GI189 Pancreatitis Gastrointestinal disorders GI190 Gastrointestinal disorders GI191 Peritoneal necrosis Gastrointestinal disorders GI192 Proctitis Gastrointestinal disorders GI193 Rectal fistula Gastrointestinal disorders GI194 Rectal hemorrhage Gastrointestinal disorders GI195 Rectal mucositis Gastrointestinal disorders GI196 Rectal necrosis Gastrointestinal disorders GI197 Rectal obstruction Gastrointestinal disorders GI198 Rectal pain

Page 4 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Gastrointestinal disorders GI199 Rectal perforation Gastrointestinal disorders GI200 Rectal stenosis Gastrointestinal disorders GI201 Rectal ulcer Gastrointestinal disorders GI202 Retroperitoneal hemorrhage Gastrointestinal disorders GI203 Salivary duct inflammation Gastrointestinal disorders GI204 Salivary gland fistula Gastrointestinal disorders GI205 Small intestinal mucositis Gastrointestinal disorders GI206 Small intestinal obstruction Gastrointestinal disorders GI207 Small intestinal perforation Gastrointestinal disorders GI208 Small intestinal stenosis Gastrointestinal disorders GI209 Small intestine ulcer Gastrointestinal disorders GI210 Stomach pain Gastrointestinal disorders GI211 Tooth development disorder Gastrointestinal disorders GI212 Gastrointestinal disorders GI213 Toothache Gastrointestinal disorders GI214 Typhlitis Gastrointestinal disorders GI215 Upper gastrointestinal hemorrhage Gastrointestinal disorders GI216 Vomiting conditions CN101 Chills conditions CN102 Death neonatal conditions CN103 Death NOS conditions CN104 face conditions CN105 Edema limbs conditions CN106 Edema trunk conditions CN107 Facial pain conditions CN108 Fatigue conditions CN109 Fever conditions CN110 Flu like symptoms conditions CN111 Gait disturbance General disorders and administration site General disorders and administration site conditions - Other, conditions CN999 specify General disorders and administration site conditions CN112 Hypothermia General disorders and administration site conditions CN113 Infusion related reaction General disorders and administration site conditions CN114 Infusion site extravasation General disorders and administration site conditions CN115 Injection site reaction General disorders and administration site conditions CN116 Irritability General disorders and administration site conditions CN117 Localized edema General disorders and administration site conditions CN118 Malaise General disorders and administration site conditions CN119 Multi-organ failure General disorders and administration site conditions CN120 Neck edema

Page 5 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

General disorders and administration site conditions CN121 Non-cardiac chest pain General disorders and administration site conditions CN122 Pain General disorders and administration site conditions CN123 Sudden death NOS Hepatobiliary disorders HP101 Bile duct stenosis Hepatobiliary disorders HP102 Biliary fistula Hepatobiliary disorders HP103 Cholecystitis Hepatobiliary disorders HP104 Gallbladder fistula Hepatobiliary disorders HP105 Gallbladder necrosis Hepatobiliary disorders HP106 Gallbladder obstruction Hepatobiliary disorders HP107 Gallbladder pain Hepatobiliary disorders HP108 Gallbladder perforation Hepatobiliary disorders HP109 Hepatic failure Hepatobiliary disorders HP110 Hepatic hemorrhage Hepatobiliary disorders HP111 Hepatic necrosis Hepatobiliary disorders HP112 Hepatic pain Hepatobiliary disorders HP999 Hepatobiliary disorders - Other, specify Hepatobiliary disorders HP113 Perforation bile duct Hepatobiliary disorders HP114 Portal Hepatobiliary disorders HP115 Portal Immune system disorders IM101 Allergic reaction Immune system disorders IM102 Anaphylaxis Immune system disorders IM103 Autoimmune disorder Immune system disorders IM104 Cytokine release syndrome Immune system disorders IM999 Immune system disorders - Other, specify Immune system disorders IM105 sickness Infections and infestations IN101 Abdominal infection Infections and infestations IN102 Anorectal infection Infections and infestations IN103 Appendicitis Infections and infestations IN104 Appendicitis perforated Infections and infestations IN105 infective Infections and infestations IN106 Biliary tract infection Infections and infestations IN107 Bladder infection Infections and infestations IN108 Bone infection Infections and infestations IN109 Breast infection Infections and infestations IN110 Bronchial infection Infections and infestations IN111 Catheter related infection Infections and infestations IN112 Cecal infection Infections and infestations IN113 Cervicitis infection Infections and infestations IN114 Conjunctivitis infective Infections and infestations IN115 Corneal infection Infections and infestations IN116 Cranial nerve infection Infections and infestations IN117 Device related infection Infections and infestations IN118 Duodenal infection Infections and infestations IN119 Encephalitis infection Infections and infestations IN120 Encephalomyelitis infection Infections and infestations IN121 Endocarditis infective

Page 6 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Infections and infestations IN122 Endophthalmitis Infections and infestations IN123 Enterocolitis infectious Infections and infestations IN124 Esophageal infection Infections and infestations IN125 Eye infection Infections and infestations IN126 Gallbladder infection Infections and infestations IN127 Gum infection Infections and infestations IN128 Hepatic infection Infections and infestations IN129 Hepatitis viral Infections and infestations IN999 Infections and infestations - Other, specify Infections and infestations IN130 Infective myositis Infections and infestations IN131 Joint infection Infections and infestations IN132 Kidney infection Infections and infestations IN133 Laryngitis Infections and infestations IN134 Lip infection Infections and infestations IN135 Lung infection Infections and infestations IN136 Lymph gland infection Infections and infestations IN137 Mediastinal infection Infections and infestations IN138 Meningitis Infections and infestations IN139 Mucosal infection Infections and infestations IN140 Nail infection Infections and infestations IN141 Otitis externa Infections and infestations IN142 Otitis media Infections and infestations IN143 Ovarian infection Infections and infestations IN144 Pancreas infection Infections and infestations IN145 Papulopustular rash Infections and infestations IN146 Paronychia Infections and infestations IN147 Pelvic infection Infections and infestations IN148 Penile infection Infections and infestations IN149 Periorbital infection Infections and infestations IN150 Peripheral nerve infection Infections and infestations IN151 Peritoneal infection Infections and infestations IN152 Pharyngitis Infections and infestations IN153 infective Infections and infestations IN154 Pleural infection Infections and infestations IN155 Prostate infection Infections and infestations IN156 Rash pustular Infections and infestations IN157 Rhinitis infective Infections and infestations IN158 Salivary gland infection Infections and infestations IN159 Scrotal infection Infections and infestations IN160 Infections and infestations IN161 Sinusitis Infections and infestations IN162 Skin infection Infections and infestations IN163 Small intestine infection Infections and infestations IN164 Soft tissue infection Infections and infestations IN165 Splenic infection Infections and infestations IN166 Stoma site infection Infections and infestations IN167 Tooth infection Infections and infestations IN168 Tracheitis

Page 7 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Infections and infestations IN169 Upper respiratory infection Infections and infestations IN170 Urethral infection Infections and infestations IN171 Urinary tract infection Infections and infestations IN172 Uterine infection Infections and infestations IN173 Vaginal infection Infections and infestations IN174 Vulval infection Infections and infestations IN175 Wound infection Injury, poisoning and procedural complications IP101 Ankle fracture Injury, poisoning and procedural complications IP102 Aortic injury Injury, poisoning and procedural complications IP103 Arterial injury Injury, poisoning and procedural complications IP104 Biliary anastomotic leak Injury, poisoning and procedural complications IP105 Bladder anastomotic leak Injury, poisoning and procedural complications IP106 Bruising Injury, poisoning and procedural complications IP107 Burn Injury, poisoning and procedural complications IP108 Dermatitis radiation Injury, poisoning and procedural complications IP109 Esophageal anastomotic leak Injury, poisoning and procedural complications IP110 Fall Injury, poisoning and procedural complications IP111 Fallopian tube anastomotic leak Injury, poisoning and procedural complications IP112 Fallopian tube perforation Injury, poisoning and procedural complications IP113 Fracture Injury, poisoning and procedural complications IP114 Gastric anastomotic leak Injury, poisoning and procedural complications IP115 Gastrointestinal anastomotic leak Injury, poisoning and procedural complications IP116 Gastrointestinal stoma necrosis Injury, poisoning and procedural complications IP117 Hip fracture Injury, poisoning and procedural complications IP118 Injury to carotid Injury, poisoning and procedural complications IP119 Injury to inferior vena cava Injury, poisoning and procedural complications IP120 Injury to jugular vein Injury, poisoning and procedural complications IP121 Injury to superior vena cava Injury, poisoning and procedural complications IP999 Injury, poisoning and procedural complications - Other, specify

Page 8 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Injury, poisoning and procedural complications IP122 Intestinal stoma leak Injury, poisoning and procedural complications IP123 Intestinal stoma obstruction Injury, poisoning and procedural complications IP124 Intestinal stoma site bleeding Injury, poisoning and procedural complications IP125 Intraoperative arterial injury Injury, poisoning and procedural complications IP126 Intraoperative breast injury Injury, poisoning and procedural complications IP127 Intraoperative cardiac injury Injury, poisoning and procedural complications IP128 Intraoperative ear injury Injury, poisoning and procedural complications IP129 Intraoperative endocrine injury Injury, poisoning and procedural complications IP130 Intraoperative gastrointestinal injury Injury, poisoning and procedural complications IP131 Intraoperative head and neck injury Injury, poisoning and procedural complications IP132 Intraoperative hemorrhage Injury, poisoning and procedural complications IP133 Intraoperative hepatobiliary injury Injury, poisoning and procedural complications IP134 Intraoperative musculoskeletal injury Injury, poisoning and procedural complications IP135 Intraoperative neurological injury Injury, poisoning and procedural complications IP136 Intraoperative ocular injury Injury, poisoning and procedural complications IP137 Intraoperative renal injury Injury, poisoning and procedural complications IP138 Intraoperative reproductive tract injury Injury, poisoning and procedural complications IP139 Intraoperative respiratory injury Injury, poisoning and procedural complications IP140 Intraoperative skin injury Injury, poisoning and procedural complications IP141 Intraoperative splenic injury Injury, poisoning and procedural complications IP142 Intraoperative urinary injury Injury, poisoning and procedural complications IP143 Intraoperative venous injury Injury, poisoning and procedural complications IP144 Kidney anastomotic leak Injury, poisoning and procedural complications IP145 Large intestinal anastomotic leak Injury, poisoning and procedural complications IP146 Pancreatic anastomotic leak

Page 9 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Injury, poisoning and procedural complications IP147 Pharyngeal anastomotic leak Injury, poisoning and procedural complications IP148 Postoperative hemorrhage Injury, poisoning and procedural complications IP149 Postoperative thoracic procedure complication Injury, poisoning and procedural complications IP150 Prolapse of intestinal stoma Injury, poisoning and procedural complications IP151 Prolapse of urostomy Injury, poisoning and procedural complications IP152 Radiation recall reaction (dermatologic) Injury, poisoning and procedural complications IP153 Rectal anastomotic leak Injury, poisoning and procedural complications IP154 Seroma Injury, poisoning and procedural complications IP155 Small intestinal anastomotic leak Injury, poisoning and procedural complications IP156 Spermatic cord anastomotic leak Injury, poisoning and procedural complications IP157 Spinal fracture Injury, poisoning and procedural complications IP158 Stenosis of gastrointestinal stoma Injury, poisoning and procedural complications IP159 Stomal ulcer Injury, poisoning and procedural complications IP160 Tracheal hemorrhage Injury, poisoning and procedural complications IP161 Tracheal obstruction Injury, poisoning and procedural complications IP162 Tracheostomy site bleeding Injury, poisoning and procedural complications IP163 Ureteric anastomotic leak Injury, poisoning and procedural complications IP164 Urethral anastomotic leak Injury, poisoning and procedural complications IP165 Urostomy leak Injury, poisoning and procedural complications IP166 Urostomy obstruction Injury, poisoning and procedural complications IP167 Urostomy site bleeding Injury, poisoning and procedural complications IP168 Urostomy stenosis Injury, poisoning and procedural complications IP169 Uterine anastomotic leak Injury, poisoning and procedural complications IP170 Uterine perforation Injury, poisoning and procedural complications IP171 Vaginal anastomotic leak

Page 10 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Injury, poisoning and procedural complications IP172 Vas deferens anastomotic leak Injury, poisoning and procedural complications IP173 Vascular access complication Injury, poisoning and procedural complications IP174 Venous injury Injury, poisoning and procedural complications IP175 Wound complication Injury, poisoning and procedural complications IP176 Wound dehiscence Injury, poisoning and procedural complications IP177 Wrist fracture Investigations IV101 Activated partial thromboplastin time prolonged Investigations IV102 Alanine aminotransferase increased Investigations IV103 Alkaline phosphatase increased Investigations IV104 Aspartate aminotransferase increased Investigations IV105 Blood antidiuretic hormone abnormal Investigations IV106 Blood bilirubin increased Investigations IV107 Blood corticotrophin decreased Investigations IV108 Blood gonadotrophin abnormal Investigations IV109 Blood prolactin abnormal Investigations IV110 Carbon monoxide diffusing capacity decreased Investigations IV111 Cardiac troponin I increased Investigations IV112 Cardiac troponin T increased Investigations IV113 CD4 lymphocytes decreased Investigations IV114 high Investigations IV115 CPK increased Investigations IV116 Creatinine increased Investigations IV117 Ejection fraction decreased Investigations IV118 Electrocardiogram QT corrected interval prolonged Investigations IV119 Fibrinogen decreased Investigations IV120 Forced expiratory volume decreased Investigations IV121 GGT increased Investigations IV122 Growth hormone abnormal Investigations IV123 Haptoglobin decreased Investigations IV124 increased Investigations IV125 INR increased Investigations IV999 Investigations - Other, specify Investigations IV126 Lipase increased Investigations IV127 Lymphocyte count decreased Investigations IV128 Lymphocyte count increased Investigations IV129 Neutrophil count decreased Investigations IV130 Pancreatic enzymes decreased Investigations IV131 Platelet count decreased Investigations IV132 Serum amylase increased Investigations IV133 output decreased Investigations IV134 Vital capacity abnormal Investigations IV135 Weight gain Investigations IV136 Weight loss

Page 11 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Investigations IV137 White blood cell decreased Metabolism and nutrition disorders ME101 Acidosis Metabolism and nutrition disorders ME102 Alcohol intolerance Metabolism and nutrition disorders ME103 Alkalosis Metabolism and nutrition disorders ME104 Anorexia Metabolism and nutrition disorders ME105 Metabolism and nutrition disorders ME106 Glucose intolerance Metabolism and nutrition disorders ME107 Hypercalcemia Metabolism and nutrition disorders ME108 Hyperglycemia Metabolism and nutrition disorders ME109 Hyperkalemia Metabolism and nutrition disorders ME110 Hypermagnesemia Metabolism and nutrition disorders ME111 Hypernatremia Metabolism and nutrition disorders ME112 Hypertriglyceridemia Metabolism and nutrition disorders ME113 Hyperuricemia Metabolism and nutrition disorders ME114 Metabolism and nutrition disorders ME115 Hypocalcemia Metabolism and nutrition disorders ME116 Hypoglycemia Metabolism and nutrition disorders ME117 Hypokalemia Metabolism and nutrition disorders ME118 Hypomagnesemia Metabolism and nutrition disorders ME119 Hyponatremia Metabolism and nutrition disorders ME120 Hypophosphatemia Metabolism and nutrition disorders ME121 Iron overload Metabolism and nutrition disorders ME999 Metabolism and nutrition disorders - Other, specify Metabolism and nutrition disorders ME122 Obesity Metabolism and nutrition disorders ME123 Tumor lysis syndrome Musculoskeletal and connective tissue disorders MU101 Abdominal soft tissue necrosis Musculoskeletal and connective tissue disorders MU102 Arthralgia Musculoskeletal and connective tissue disorders MU103 Arthritis Musculoskeletal and connective tissue disorders MU104 Avascular necrosis Musculoskeletal and connective tissue disorders MU105 Back pain Musculoskeletal and connective tissue disorders MU106 Bone pain Musculoskeletal and connective tissue disorders MU107 Buttock pain Musculoskeletal and connective tissue disorders MU108 Chest wall pain Musculoskeletal and connective tissue disorders MU109 Exostosis Musculoskeletal and connective tissue disorders MU110 Fibrosis deep connective tissue Musculoskeletal and connective tissue disorders MU111 Flank pain Musculoskeletal and connective tissue disorders MU112 Generalized muscle weakness

Page 12 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Musculoskeletal and connective tissue disorders MU113 Growth suppression Musculoskeletal and connective tissue disorders MU114 Head soft tissue necrosis Musculoskeletal and connective tissue disorders MU115 Joint effusion Musculoskeletal and connective tissue disorders MU116 Joint range of motion decreased Musculoskeletal and connective tissue disorders MU117 Joint range of motion decreased cervical spine Musculoskeletal and connective tissue disorders MU118 Joint range of motion decreased lumbar spine Musculoskeletal and connective tissue disorders MU119 Kyphosis Musculoskeletal and connective tissue disorders MU120 Lordosis Musculoskeletal and connective tissue disorders MU121 Muscle weakness left-sided Musculoskeletal and connective tissue disorders MU122 Muscle weakness lower limb Musculoskeletal and connective tissue disorders MU123 Muscle weakness right-sided Musculoskeletal and connective tissue disorders MU124 Muscle weakness trunk Musculoskeletal and connective tissue disorders MU125 Muscle weakness upper limb Musculoskeletal and connective tissue disorders MU999 Musculoskeletal and connective tissue disorder - Other, specify Musculoskeletal and connective tissue disorders MU126 Musculoskeletal deformity Musculoskeletal and connective tissue disorders MU127 Myalgia Musculoskeletal and connective tissue disorders MU128 Myositis Musculoskeletal and connective tissue disorders MU129 Neck pain Musculoskeletal and connective tissue disorders MU130 Neck soft tissue necrosis Musculoskeletal and connective tissue disorders MU131 Osteonecrosis of jaw Musculoskeletal and connective tissue disorders MU132 Osteoporosis Musculoskeletal and connective tissue disorders MU133 Pain in extremity Musculoskeletal and connective tissue disorders MU134 Pelvic soft tissue necrosis Musculoskeletal and connective tissue disorders MU135 Scoliosis Musculoskeletal and connective tissue disorders MU136 Soft tissue necrosis lower limb

Page 13 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Musculoskeletal and connective tissue disorders MU137 Soft tissue necrosis upper limb Musculoskeletal and connective tissue disorders MU138 Superficial soft tissue fibrosis Musculoskeletal and connective tissue disorders MU139 Musculoskeletal and connective tissue disorders MU140 Unequal limb length Neoplasms benign, malignant and unspecified (incl cysts and polyps) NP101 Leukemia secondary to oncology chemotherapy Neoplasms benign, malignant and unspecified (incl cysts and polyps) NP102 Myelodysplastic syndrome Neoplasms benign, malignant and Neoplasms benign, malignant and unspecified (incl cysts and unspecified (incl cysts and polyps) NP999 polyps) - Other, specify Neoplasms benign, malignant and unspecified (incl cysts and polyps) NP103 Treatment related secondary malignancy Neoplasms benign, malignant and unspecified (incl cysts and polyps) NP104 Tumor pain Nervous system disorders NE101 Abducens nerve disorder Nervous system disorders NE102 Accessory nerve disorder Nervous system disorders NE103 Acoustic nerve disorder NOS Nervous system disorders NE104 Akathisia Nervous system disorders NE105 Amnesia Nervous system disorders NE106 Aphonia Nervous system disorders NE107 Arachnoiditis Nervous system disorders NE108 Ataxia Nervous system disorders NE109 Brachial plexopathy Nervous system disorders NE110 Central nervous system necrosis Nervous system disorders NE111 Cerebrospinal fluid leakage Nervous system disorders NE112 Cognitive disturbance Nervous system disorders NE113 Concentration impairment Nervous system disorders NE114 Depressed level of consciousness Nervous system disorders NE115 Dizziness Nervous system disorders NE116 Dysarthria Nervous system disorders NE117 Dysesthesia Nervous system disorders NE118 Dysgeusia Nervous system disorders NE119 Dysphasia Nervous system disorders NE120 Edema cerebral Nervous system disorders NE121 Encephalopathy Nervous system disorders NE122 Extrapyramidal disorder Nervous system disorders NE123 Facial muscle weakness Nervous system disorders NE124 Facial nerve disorder Nervous system disorders NE125 Glossopharyngeal nerve disorder Nervous system disorders NE126 Headache Nervous system disorders NE127 Hydrocephalus Nervous system disorders NE128 Hypersomnia Nervous system disorders NE129 Hypoglossal nerve disorder Nervous system disorders NE130 Intracranial hemorrhage Nervous system disorders NE131 Ischemia cerebrovascular

Page 14 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Nervous system disorders NE132 IVth nerve disorder Nervous system disorders NE133 Lethargy Nervous system disorders NE134 Leukoencephalopathy Nervous system disorders NE135 Memory impairment Nervous system disorders NE136 Meningismus Nervous system disorders NE137 Movements involuntary Nervous system disorders NE138 Myelitis Nervous system disorders NE999 Nervous system disorders - Other, specify Nervous system disorders NE139 Neuralgia Nervous system disorders NE140 Nystagmus Nervous system disorders NE141 Oculomotor nerve disorder Nervous system disorders NE142 Olfactory nerve disorder Nervous system disorders NE143 Paresthesia Nervous system disorders NE144 Peripheral motor neuropathy Nervous system disorders NE145 Peripheral sensory neuropathy Nervous system disorders NE146 Phantom pain Nervous system disorders NE147 Presyncope Nervous system disorders NE148 Pyramidal tract syndrome Nervous system disorders NE149 Radiculitis Nervous system disorders NE150 Recurrent laryngeal nerve palsy Nervous system disorders NE151 Reversible posterior leukoencephalopathy syndrome Nervous system disorders NE152 Seizure Nervous system disorders NE153 Sinus pain Nervous system disorders NE154 Somnolence Nervous system disorders NE155 Spasticity Nervous system disorders NE156 Stroke Nervous system disorders NE157 Nervous system disorders NE158 Transient ischemic attacks Nervous system disorders NE159 Tremor Nervous system disorders NE160 Trigeminal nerve disorder Nervous system disorders NE161 Vagus nerve disorder Nervous system disorders NE162 Vasovagal reaction Pregnancy, puerperium and perinatal conditions OB101 Fetal death Pregnancy, puerperium and perinatal conditions OB102 Fetal growth retardation Pregnancy, puerperium and perinatal conditions OB999 Pregnancy, puerperium and perinatal conditions - Other, specify Pregnancy, puerperium and perinatal conditions OB103 Premature delivery Pregnancy, puerperium and perinatal conditions OB104 Unintended pregnancy Psychiatric disorders PS101 Agitation Psychiatric disorders PS102 Anorgasmia Psychiatric disorders PS103 Anxiety Psychiatric disorders PS104 Confusion Psychiatric disorders PS105 Delayed orgasm Psychiatric disorders PS106 Delirium Psychiatric disorders PS107 Delusions

Page 15 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Psychiatric disorders PS108 Depression Psychiatric disorders PS109 Euphoria Psychiatric disorders PS110 Hallucinations Psychiatric disorders PS111 Insomnia Psychiatric disorders PS112 Libido decreased Psychiatric disorders PS113 Libido increased Psychiatric disorders PS114 Mania Psychiatric disorders PS115 Personality change Psychiatric disorders PS999 Psychiatric disorders - Other, specify Psychiatric disorders PS116 Psychosis Psychiatric disorders PS117 Restlessness Psychiatric disorders PS118 Suicidal ideation Psychiatric disorders PS119 Suicide attempt Renal and urinary disorders RE101 Renal and urinary disorders RE102 Bladder perforation Renal and urinary disorders RE103 Bladder spasm Renal and urinary disorders RE104 Chronic kidney disease Renal and urinary disorders RE105 Cystitis noninfective Renal and urinary disorders RE106 Hematuria Renal and urinary disorders RE107 Hemoglobinuria Renal and urinary disorders RE108 Proteinuria Renal and urinary disorders RE999 Renal and urinary disorders - Other, specify Renal and urinary disorders RE109 Renal calculi Renal and urinary disorders RE110 Renal colic Renal and urinary disorders RE111 Renal hemorrhage Renal and urinary disorders RE112 Urinary fistula Renal and urinary disorders RE113 Urinary frequency Renal and urinary disorders RE114 Urinary incontinence Renal and urinary disorders RE115 Urinary retention Renal and urinary disorders RE116 Urinary tract obstruction Renal and urinary disorders RE117 Urinary tract pain Renal and urinary disorders RE118 Urinary urgency Renal and urinary disorders RE119 Urine discoloration Reproductive system and breast disorders SX101 Azoospermia Reproductive system and breast disorders SX102 Breast atrophy Reproductive system and breast disorders SX103 Breast pain Reproductive system and breast disorders SX104 Dysmenorrhea Reproductive system and breast disorders SX105 Dyspareunia Reproductive system and breast disorders SX106 Ejaculation disorder Reproductive system and breast disorders SX107 Erectile dysfunction Reproductive system and breast disorders SX108 Fallopian tube obstruction Reproductive system and breast disorders SX109 Fallopian tube stenosis Reproductive system and breast disorders SX110 Female genital tract fistula Reproductive system and breast disorders SX111 Feminization acquired Reproductive system and breast disorders SX112 Genital edema Reproductive system and breast disorders SX113 Gynecomastia Reproductive system and breast disorders SX114 Hematosalpinx Reproductive system and breast disorders SX115 Irregular menstruation

Page 16 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Reproductive system and breast disorders SX116 Lactation disorder Reproductive system and breast disorders SX117 Menorrhagia Reproductive system and breast disorders SX118 Nipple deformity Reproductive system and breast disorders SX119 Oligospermia Reproductive system and breast disorders SX120 Ovarian hemorrhage Reproductive system and breast disorders SX121 Ovarian rupture Reproductive system and breast disorders SX122 Ovulation pain Reproductive system and breast disorders SX123 Pelvic floor muscle weakness Reproductive system and breast disorders SX124 Pelvic pain Reproductive system and breast disorders SX125 Penile pain Reproductive system and breast disorders SX126 Perineal pain Reproductive system and breast disorders SX127 Premature menopause Reproductive system and breast disorders SX128 Prostatic hemorrhage Reproductive system and breast disorders SX129 Prostatic obstruction Reproductive system and breast disorders SX130 Prostatic pain

Reproductive system and breast disorders SX999 Reproductive system and breast disorders - Other, specify Reproductive system and breast disorders SX131 Scrotal pain Reproductive system and breast disorders SX132 Spermatic cord hemorrhage Reproductive system and breast disorders SX133 Spermatic cord obstruction Reproductive system and breast disorders SX134 Testicular disorder Reproductive system and breast disorders SX135 Testicular hemorrhage Reproductive system and breast disorders SX136 Testicular pain Reproductive system and breast disorders SX137 Uterine fistula Reproductive system and breast disorders SX138 Uterine hemorrhage Reproductive system and breast disorders SX139 Uterine obstruction Reproductive system and breast disorders SX140 Uterine pain Reproductive system and breast disorders SX141 Vaginal discharge Reproductive system and breast disorders SX142 Vaginal dryness Reproductive system and breast disorders SX143 Vaginal fistula Reproductive system and breast disorders SX144 Vaginal hemorrhage Reproductive system and breast disorders SX145 Vaginal inflammation Reproductive system and breast disorders SX146 Vaginal obstruction Reproductive system and breast disorders SX147 Vaginal pain Reproductive system and breast disorders SX148 Vaginal perforation Reproductive system and breast disorders SX149 Vaginal stricture Reproductive system and breast disorders SX150 Vaginismus Respiratory, thoracic and mediastinal disorders PU101 Adult respiratory distress syndrome Respiratory, thoracic and mediastinal disorders PU102 Allergic rhinitis Respiratory, thoracic and mediastinal disorders PU103 Apnea Respiratory, thoracic and mediastinal disorders PU104 Aspiration Respiratory, thoracic and mediastinal disorders PU105 Atelectasis Respiratory, thoracic and mediastinal disorders PU106 Bronchial fistula

Page 17 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Respiratory, thoracic and mediastinal disorders PU107 Bronchial obstruction Respiratory, thoracic and mediastinal disorders PU108 Bronchial stricture Respiratory, thoracic and mediastinal disorders PU109 Bronchopleural fistula Respiratory, thoracic and mediastinal disorders PU110 Bronchopulmonary hemorrhage Respiratory, thoracic and mediastinal disorders PU111 Bronchospasm Respiratory, thoracic and mediastinal disorders PU112 Chylothorax Respiratory, thoracic and mediastinal disorders PU113 Cough Respiratory, thoracic and mediastinal disorders PU114 Dyspnea Respiratory, thoracic and mediastinal disorders PU115 Epistaxis Respiratory, thoracic and mediastinal disorders PU116 Hiccups Respiratory, thoracic and mediastinal disorders PU117 Hoarseness Respiratory, thoracic and mediastinal disorders PU118 Hypoxia Respiratory, thoracic and mediastinal disorders PU119 Laryngeal edema Respiratory, thoracic and mediastinal disorders PU120 Laryngeal fistula Respiratory, thoracic and mediastinal disorders PU121 Laryngeal hemorrhage Respiratory, thoracic and mediastinal disorders PU122 Laryngeal inflammation Respiratory, thoracic and mediastinal disorders PU123 Laryngeal mucositis Respiratory, thoracic and mediastinal disorders PU124 Laryngeal obstruction Respiratory, thoracic and mediastinal disorders PU125 Laryngeal stenosis Respiratory, thoracic and mediastinal disorders PU126 Laryngopharyngeal dysesthesia Respiratory, thoracic and mediastinal disorders PU127 Laryngospasm Respiratory, thoracic and mediastinal disorders PU128 Mediastinal hemorrhage Respiratory, thoracic and mediastinal disorders PU129 Nasal congestion Respiratory, thoracic and mediastinal disorders PU130 Pharyngeal fistula Respiratory, thoracic and mediastinal disorders PU131 Pharyngeal hemorrhage

Page 18 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Respiratory, thoracic and mediastinal disorders PU132 Pharyngeal mucositis Respiratory, thoracic and mediastinal disorders PU133 Pharyngeal necrosis Respiratory, thoracic and mediastinal disorders PU134 Pharyngeal stenosis Respiratory, thoracic and mediastinal disorders PU135 Pharyngolaryngeal pain Respiratory, thoracic and mediastinal disorders PU136 Pleural effusion Respiratory, thoracic and mediastinal disorders PU137 Pleural hemorrhage Respiratory, thoracic and mediastinal disorders PU138 Pleuritic pain Respiratory, thoracic and mediastinal disorders PU139 Pneumonitis Respiratory, thoracic and mediastinal disorders PU140 Pneumothorax Respiratory, thoracic and mediastinal disorders PU141 Postnasal drip Respiratory, thoracic and mediastinal disorders PU142 Productive cough Respiratory, thoracic and mediastinal disorders PU143 Respiratory, thoracic and mediastinal disorders PU144 Pulmonary fibrosis Respiratory, thoracic and mediastinal disorders PU145 Pulmonary fistula Respiratory, thoracic and mediastinal disorders PU146 Respiratory, thoracic and mediastinal disorders PU147 Respiratory failure Respiratory, thoracic and mediastinal disorders PU999 Respiratory, thoracic and mediastinal disorders - Other, specify Respiratory, thoracic and mediastinal disorders PU148 Retinoic acid syndrome Respiratory, thoracic and mediastinal disorders PU149 Sinus disorder Respiratory, thoracic and mediastinal disorders PU150 Sleep apnea Respiratory, thoracic and mediastinal disorders PU151 Sneezing Respiratory, thoracic and mediastinal disorders PU152 Sore throat Respiratory, thoracic and mediastinal disorders PU153 Stridor Respiratory, thoracic and mediastinal disorders PU154 Tracheal fistula Respiratory, thoracic and mediastinal disorders PU155 Tracheal mucositis

Page 19 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Respiratory, thoracic and mediastinal disorders PU156 Tracheal stenosis Respiratory, thoracic and mediastinal disorders PU157 Voice alteration Respiratory, thoracic and mediastinal disorders PU158 Wheezing Skin and subcutaneous tissue disorders DE101 Alopecia Skin and subcutaneous tissue disorders DE102 Body odor Skin and subcutaneous tissue disorders DE103 Bullous dermatitis Skin and subcutaneous tissue disorders DE104 Dry skin Skin and subcutaneous tissue disorders DE105 Skin and subcutaneous tissue disorders DE106 Erythroderma Skin and subcutaneous tissue disorders DE107 atrophy Skin and subcutaneous tissue disorders DE108 Hirsutism Skin and subcutaneous tissue disorders DE109 Hyperhidrosis Skin and subcutaneous tissue disorders DE110 Hypertrichosis Skin and subcutaneous tissue disorders DE111 Hypohidrosis Skin and subcutaneous tissue disorders DE112 Lipohypertrophy Skin and subcutaneous tissue disorders DE113 Nail discoloration Skin and subcutaneous tissue disorders DE114 Nail loss Skin and subcutaneous tissue disorders DE115 Nail ridging Skin and subcutaneous tissue disorders DE116 Pain of skin Skin and subcutaneous tissue disorders DE117 Palmar-plantar erythrodysesthesia syndrome Skin and subcutaneous tissue disorders DE118 Periorbital edema Skin and subcutaneous tissue disorders DE119 Photosensitivity Skin and subcutaneous tissue disorders DE120 Pruritus Skin and subcutaneous tissue disorders DE121 Purpura Skin and subcutaneous tissue disorders DE122 Rash acneiform Skin and subcutaneous tissue disorders DE123 Rash maculo-papular Skin and subcutaneous tissue disorders DE124 Scalp pain Skin and subcutaneous tissue disorders DE999 Skin and subcutaneous tissue disorders - Other, specify Skin and subcutaneous tissue disorders DE125 Skin atrophy Skin and subcutaneous tissue disorders DE126 Skin hyperpigmentation Skin and subcutaneous tissue disorders DE127 Skin hypopigmentation Skin and subcutaneous tissue disorders DE128 Skin induration Skin and subcutaneous tissue disorders DE129 Skin ulceration Skin and subcutaneous tissue disorders DE130 Stevens-Johnson syndrome Skin and subcutaneous tissue disorders DE131 Skin and subcutaneous tissue disorders DE132 Toxic epidermal necrolysis Skin and subcutaneous tissue disorders DE133 Urticaria Social circumstances SX151 Menopause Social circumstances SX998 Social circumstances - Other, specify Surgical and medical procedures SU198 Surgical and medical procedures - Other, specify Vascular disorders VA101 leak syndrome Vascular disorders VA102 Flushing Vascular disorders VA103 Hematoma Vascular disorders VA104 Hot flashes Vascular disorders VA105 Hypertension Vascular disorders VA106

Page 20 of 21 CTCAE v4.0 Toxicity Codes

Category ECOG Code CTCAE v4.0 Term

Vascular disorders VA107 Lymph leakage Vascular disorders VA108 Lymphedema Vascular disorders VA109 Lymphocele Vascular disorders VA110 Peripheral ischemia Vascular disorders VA111 Phlebitis Vascular disorders VA112 Superficial Vascular disorders VA113 Superior vena cava syndrome Vascular disorders VA114 Thromboembolic event Vascular disorders VA999 Vascular disorders - Other, specify Vascular disorders VA115 Vascular disorders VA116 Visceral arterial ischemia

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