ANALYSIS OF TOPICAL PREPARATIONS FOR TREATMENT OF ONYCHOMYCOSIS IN UKRAINE Vashchenko Oksana, Bilous Svitlana, Zaliska Olha, Piniazhko Oresta Danylo Halytsky Lviv National Medical University, Ukraine INTRODUCTION Onychomycosis is a common fungal nail infection that affects about 10% of the population. The therapeutic options for onychomycosis include oral and topical antifungals. Topical medications are used both in monotherapy, and in combination therapy. The prescribing of topical preparation should based on clinical and cost-effectiveness and should be carried out according to national health standards. to conduct comparative analysis of topical preparations for onychomycosis THE AIM OF WORK treatment included into clinical protocol and State Formulary of Ukraine R E S U L T S Protocol for medical care of patients with nail State Formulary of Ukraine, 10th was approved dermatophytosis (onychomycosis) was approved by Ministry of Health of Ukraine in 2018. by Ministry of Health of Ukraine in 2009. Topical antifungal preparations included into Clinical protocol claims that topical treatment of State Formulary onychomycosis is recommended if: No. API(s) Dosage Amount Recommendation for form onychomycosis  less than 30% of the nail plate is affected; 1. Bifonazole Cutaneous solution 1 –  subungual hyperkeratosis is absent or not severe; Gel 1 –  system therapy is contraindicated. Cream 1 + (after nail removal) 2. Clotrimazole Cutaneous solution 2 – Clinical protocol recommends: Cutaneous powder 1 – 1) to remove nail plate by the following Cream 3 – onycholytic preparations: Ointment 4 – 3. Econazole Gel 1 – No. Preparation Dosage API(s) State Register Cream 1 + (under occlusive dressing) form of Drugs 4. Ketoconazole Cream 5 – 1. Onychoplast Plaster Urea – 5. Isoconazole Cream 1 – 2. Ureaplast Plaster Urea – 6. Miconazole Gel 1 + (after nail removal) 3. Treatment set Ointment Bifonazole + urea + Cream 2 + (after nail removal) 2) to treat nail bed by topical antifungals such as: 7. Nystatin Ointment 1 – 8. Terbinafine Cutaneous solution 1 – . nail lacquers Cutaneous spray 3 – API State Register of Drugs Gel 5 – Ciclopirox – Cream 6 – Amorolfine 4 9. Natamycin + Cream 1 – Neomycin . topical preparations with ketoconazole, sulphate + Hydrocortisone terbinafine, oxiconazole, miconazole, Ointment 1 – chlornitrophenol, undecylenic acid, combination 42 5 preparation with ketoconazole and salicylic acid API Preferred dosage form CONCLUSIONS Known Not indicated  There are gaps between clinical protocol and State Formulary. Analyzed Clinical State  Clinical protocol should be reviewed in recommendation protocol Formulary accordance to data of evidence-based medicine. Onycholytic + –  State Formulary does not include antifungal preparations lacquers, which are broadly used and Dosage forms It recommends nail It does not include lacquers or other nail lacquers and recommended, for example, by British National antifungals without recommends Formulary. indicating the antifungal creams and  It is also necessary to analyze antifungal nail dosage form gel lacquers for making decision about including Antifungal agents 7 3 them into State Formulary of Ukraine.