Special Edition 64Th Lindau Nobel Laureate
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RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA
GENES AND PROTEINS THAT CONTROL THE SECRETORY PATHWAY Nobel Lecture, 7 December 2013 by RANDY SCHEKMAN Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, USA. Introduction George Palade shared the 1974 Nobel Prize with Albert Claude and Christian de Duve for their pioneering work in the characterization of organelles interrelated by the process of secretion in mammalian cells and tissues. These three scholars established the modern field of cell biology and the tools of cell fractionation and thin section transmission electron microscopy. It was Palade’s genius in particular that revealed the organization of the secretory pathway. He discovered the ribosome and showed that it was poised on the surface of the endoplasmic reticulum (ER) where it engaged in the vectorial translocation of newly synthesized secretory polypeptides (1). And in a most elegant and technically challenging investigation, his group employed radioactive amino acids in a pulse-chase regimen to show by autoradiograpic exposure of thin sections on a photographic emulsion that secretory proteins progress in sequence from the ER through the Golgi apparatus into secretory granules, which then discharge their cargo by membrane fusion at the cell surface (1). He documented the role of vesicles as carriers of cargo between compartments and he formulated the hypothesis that membranes template their own production rather than form by a process of de novo biogenesis (1). As a university student I was ignorant of the important developments in cell biology; however, I learned of Palade’s work during my first year of graduate school in the Stanford biochemistry department. -
Unrestricted Immigration and the Foreign Dominance Of
Unrestricted Immigration and the Foreign Dominance of United States Nobel Prize Winners in Science: Irrefutable Data and Exemplary Family Narratives—Backup Data and Information Andrew A. Beveridge, Queens and Graduate Center CUNY and Social Explorer, Inc. Lynn Caporale, Strategic Scientific Advisor and Author The following slides were presented at the recent meeting of the American Association for the Advancement of Science. This project and paper is an outgrowth of that session, and will combine qualitative data on Nobel Prize Winners family histories along with analyses of the pattern of Nobel Winners. The first set of slides show some of the patterns so far found, and will be augmented for the formal paper. The second set of slides shows some examples of the Nobel families. The authors a developing a systematic data base of Nobel Winners (mainly US), their careers and their family histories. This turned out to be much more challenging than expected, since many winners do not emphasize their family origins in their own biographies or autobiographies or other commentary. Dr. Caporale has reached out to some laureates or their families to elicit that information. We plan to systematically compare the laureates to the population in the US at large, including immigrants and non‐immigrants at various periods. Outline of Presentation • A preliminary examination of the 609 Nobel Prize Winners, 291 of whom were at an American Institution when they received the Nobel in physics, chemistry or physiology and medicine • Will look at patterns of -
書 名 等 発行年 出版社 受賞年 備考 N1 Ueber Das Zustandekommen Der
書 名 等 発行年 出版社 受賞年 備考 Ueber das Zustandekommen der Diphtherie-immunitat und der Tetanus-Immunitat bei thieren / Emil Adolf N1 1890 Georg thieme 1901 von Behring N2 Diphtherie und tetanus immunitaet / Emil Adolf von Behring und Kitasato 19-- [Akitomo Matsuki] 1901 Malarial fever its cause, prevention and treatment containing full details for the use of travellers, University press of N3 1902 1902 sportsmen, soldiers, and residents in malarious places / by Ronald Ross liverpool Ueber die Anwendung von concentrirten chemischen Lichtstrahlen in der Medicin / von Prof. Dr. Niels N4 1899 F.C.W.Vogel 1903 Ryberg Finsen Mit 4 Abbildungen und 2 Tafeln Twenty-five years of objective study of the higher nervous activity (behaviour) of animals / Ivan N5 Petrovitch Pavlov ; translated and edited by W. Horsley Gantt ; with the collaboration of G. Volborth ; and c1928 International Publishing 1904 an introduction by Walter B. Cannon Conditioned reflexes : an investigation of the physiological activity of the cerebral cortex / by Ivan Oxford University N6 1927 1904 Petrovitch Pavlov ; translated and edited by G.V. Anrep Press N7 Die Ätiologie und die Bekämpfung der Tuberkulose / Robert Koch ; eingeleitet von M. Kirchner 1912 J.A.Barth 1905 N8 Neue Darstellung vom histologischen Bau des Centralnervensystems / von Santiago Ramón y Cajal 1893 Veit 1906 Traité des fiévres palustres : avec la description des microbes du paludisme / par Charles Louis Alphonse N9 1884 Octave Doin 1907 Laveran N10 Embryologie des Scorpions / von Ilya Ilyich Mechnikov 1870 Wilhelm Engelmann 1908 Immunität bei Infektionskrankheiten / Ilya Ilyich Mechnikov ; einzig autorisierte übersetzung von Julius N11 1902 Gustav Fischer 1908 Meyer Die experimentelle Chemotherapie der Spirillosen : Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie / N12 1910 J.Springer 1908 von Paul Ehrlich und S. -
Table of Contents (PDF)
June 28, 2016 u vol. 113 u no. 26 From the Cover 7106 Topological defects in liquid crystals E3619 Translation control in Fragile X syndrome E3686 Voltage-sensing phosphatase activities E3782 Aerobic glycolysis and learning 7261 Electric field sensing by bumblebees Contents THIS WEEK IN PNAS Cover image: Pictured is a polarized 7003 In This Issue optical micrograph of a plastic sheet with an array of holes drilled into it and suspended in a nematic-phase liquid LETTERS (ONLINE ONLY) crystal. Lisa Tran et al. found that such a sheet induced arrays of topological E3590 Reduced nitrogen dominated nitrogen deposition in the United States, but its defect lines in a nematic liquid crystal. contribution to nitrogen deposition in China decreased The authors further demonstrated how Xuejun Liu, Wen Xu, Enzai Du, Yuepeng Pan, and Keith Goulding the energy of the liquid crystal and the E3592 Reply to Liu et al.: On the importance of US deposition of nitrogen dioxide, geometry of the holes affect the defect coarse particle nitrate, and organic nitrogen patterns. The findings might have Yi Li, Bret A. Schichtel, John T. Walker, Donna B. Schwede, Xi Chen, Christopher M. B. applications in electronic displays, Lehmann, Melissa A. Puchalski, David A. Gay, and Jeffrey L. Collett Jr. where nematic liquid crystals are widely used. See the article by Tran et al. on E3594 Rise and fall of nitrogen deposition in the United States pages 7106–7111. Image courtesy of Enzai Du Lisa Tran. E3596 Adult pelvic shape change is an evolutionary side effect Philipp Mitteroecker and Barbara Fischer E3597 Reply to Mitteroecker and Fischer: Developmental solutions to the obstetrical dilemma are not Gouldian spandrels Marcia S. -
Die Woche Spezial
In cooperation with DIE WOCHE SPEZIAL >> Autographs>vs.>#NobelSelfie Special >> Big>Data>–>not>a>big>deal,> Edition just>another>tool >> Why>Don’t>Grasshoppers> Catch>Colds? SCIENCE SUMMIT The>64th>Lindau>Nobel>Laureate>Meeting> devoted>to>Physiology>and>Medicine More than 600 young scientists came to Lindau to meet 37 Nobel laureates CAREER WONGSANIT > Women>to>Women: SUPHAKIT > / > Science>and>Family FOTOLIA INFLAMMATION The>Stress>of>Ageing > FLASHPICS > / > MEETINGS > FOTOLIA LAUREATE > CANCER RESEARCH NOBEL > LINDAU > / > J.>Michael>Bishop>and GÄRTNER > FLEMMING > JUAN > / the>Discovery>of>the>first> > CHRISTIAN FOTOLIA Human>Oncogene EDITORIAL IMPRESSUM Chefredakteur: Prof. Dr. Carsten Könneker (v.i.S.d.P.) Dear readers, Redaktionsleiter: Dr. Daniel Lingenhöhl Redaktion: Antje Findeklee, Jan Dönges, Dr. Jan Osterkamp where>else>can>aspiring>young>scientists> Ständige Mitarbeiter: Lars Fischer Art Director Digital: Marc Grove meet>the>best>researchers>of>the>world> Layout: Oliver Gabriel Schlussredaktion: Christina Meyberg (Ltg.), casually,>and>discuss>their>research,>or>their> Sigrid Spies, Katharina Werle Bildredaktion: Alice Krüßmann (Ltg.), Anke Lingg, Gabriela Rabe work>–>or>pressing>global>problems?>Or> Verlag: Spektrum der Wissenschaft Verlagsgesellschaft mbH, Slevogtstraße 3–5, 69126 Heidelberg, Tel. 06221 9126-600, simply>discuss>soccer?>Probably>the>best> Fax 06221 9126-751; Amtsgericht Mannheim, HRB 338114, UStd-Id-Nr. DE147514638 occasion>is>the>annual>Lindau>Nobel>Laure- Geschäftsleitung: Markus Bossle, Thomas Bleck Marketing und Vertrieb: Annette Baumbusch (Ltg.) Leser- und Bestellservice: Helga Emmerich, Sabine Häusser, ate>Meeting>in>the>lovely>Bavarian>town>of> Ute Park, Tel. 06221 9126-743, E-Mail: [email protected] Lindau>on>Lake>Constance. Die Spektrum der Wissenschaft Verlagsgesellschaft mbH ist Kooperati- onspartner des Nationalen Instituts für Wissenschaftskommunikation Daniel>Lingenhöhl> GmbH (NaWik). -
Aaron Ciechanover 2004 Nobel Laureate in Chemistry
TRINITY COLLEGE DUBLIN Medical Research at the Cutting Edge Progress in the fight against Inflammatory Diseases and Cancer Joint Symposium of the Trinity Biomedical Sciences Institute and The Weizmann Institute of Science Tercentenary Hall, Trinity Biomedical Sciences Institute Keynote Speakers July 27-29, 2014 Bruce Beutler 2011 Nobel Laureate in Speakers Physiology and Medicine Opening Address Minister Sean Sherlock TD, University of Texas Minister for Research and Innovation, Irish Government. Aaron Ciechanover Ireland Israel 2004 Nobel Laureate in Chemistry Luke O’Neill Ruth Arnon Technion Israel Institute of TBSI Academic Director The President of the Israel Academy of Technology Diarmuid O’Brien Sciences and Humanities Director of Trinity Research and Mudi Sheves Marc Feldmann Innovation The Weizmann Institute of Science 2003 Albert Lasker Award Andrew Bowie Vice President for Technology Transfer for Clinical Medical Research Trinity Biomedical Sciences Inst. Ido Amit University of Oxford Paul Brown Weizmann Institute of Science England Trinity College Dublin Yinon Ben-Neriah Martin Caffrey Hebrew Univ. of Jerusalem Jules Hoffmann Trinity Biomedical Sciences Inst. 2011 Nobel Laureate in Ashraf Brik Gavin Davey Physiology and Medicine Ben Gurion University Trinity Biomedical Sciences Inst. Institut de Biologie Moleculaire Steffen Jung et Cellulaire, France Aisling Dunne Trinity Biomedical Sciences Inst. Weizmann Institute of Science James Watson Padraic Fallon Eran Elinav 1962 Nobel Laureate in Trinity Biomedical Sciences Inst. Weizmann Institute of Science Physiology and Medicine Alan Irvine Yehuda Kamari Cold Spring Harbor Laboratory Trinity College Dublin Sheba Medical Center New York Vincent Kelly Irit Sagi Trinity Biomedical Sciences Inst. Weizmann Institute of Science Ada Yonath Seamus Martin Idit Shachar 2009 Nobel Laureate in Trinity College Dublin Weizmann Institute of Science Chemistry Kingston Mills David Wallach Weizmann Institute of Science, Trinity Biomedical Sciences Inst. -
Nobel Endeavors in Immunology Introducing Dr
SPRING 2012 A PUBLICATION OF SOUTHWESTERN MEDICAL FOUNDATION Nobel Endeavors in Immunology Introducing Dr. Bruce Beutler, UT Southwestern’s fifth Nobel Laureate, and the new Center for the Genetics of Host Defense Southwestern Medical Foundation Board of Trustees 2011-2012 Edward M. Ackerman Joe M. Haggar, III Richard R. Pollock Sara Melnick Albert Nancy S. Halbreich Caren H. Prothro The Heritage Society Rafael M. Anchia LaQuita C. Hall Carolyn Perot Rathjen OF SOUTHWESTERN MEDICAL FOUNDATION Table of Contents Charlotte Jones Anderson Paul W. Harris* Mike Rawlings table of contents Barry G. Andrews Linda W. Hart Jean W. Roach Joyce T. Alban Mr. and Mrs. Thomas E. McCullough Marilyn H. Augur Joe V. (Jody) Hawn, Jr. Linda Robuck Mr. and Mrs. James R. Alexander Christopher F. McGratty Robert D. Rogers Ralph W. Babb, Jr. Jess T. Hay Anonymous (11) Carmen Crews McCracken McMillan Editor Doris L. Bass Frederick B. Hegi, Jr. Catherine M. Rose George A. Atnip# Ferd C. and Carole W. Meyer Nobel Endeavors in Immunology Peter Beck Jeffrey M. Heller* Billy Rosenthal Marilyn Augur* William R. and Anne E. Montgomery Heidi Harris Cannella The threads of Dr. Bruce Beutler’s scientific 3 # Jill C. Bee Julie K. Hersh Lizzie Horchow Routman* Paul M. Bass* Kay Y. Moran career are inextricably woven into the fabric of W. Robert Beavers, M.D. Barbara and Robert Munford Gil J. Besing Thomas O. Hicks Robert B. Rowling* Creative Director UT Southwestern’s history. From intern to mid-career Drs. Paul R. and Robert H. Munger# Jan Hart Black Sally S. Hoglund Stephen H. -
Randy W. Schekman, Phd
Randy W. Schekman, PhD Current Position Professor of molecular and cell biology at the University of California, Berkeley Investigator at the Howard Hughes Medical Institute Editor-in-Chief, eLIFE Journal Education BA, molecular biology, University of California, Los Angeles PhD, biochemistry, Stanford University Awards Nobel Prize in Physiology or Medicine 2013 (shared with James E. Rothman and Thomas C. Südhof ) Albert Lasker Award for Basic Medical Research Eli Lilly Research Award in Microbiology and Immunology Lewis S. Rosenstiel Award in Basic Biomedical Science, Brandeis University Gairdner Foundation International Award Louisa Gross Horwitz Prize, Columbia University 2008 Dickson Prize in Medicine, University of Pittsburgh E.B. Wilson Medal, American Society for Cell Biology Memberships US National Academy of Sciences American Academy of Arts and Sciences American Society of Cell Biology American Association for the Advancement of Science American Philosophical Society Biography Traffic inside a cell is as complicated as rush hour near any metropolitan area. But drivers know how to follow the signs and roadways to reach their destinations. How do different cellular proteins "read" molecular signposts to find their way inside or outside of a cell? For the past three decades, Randy Schekman has been characterizing the traffic drivers that shuttle cellular proteins as they move in membrane-bound sacs, or vesicles, within a cell. His detailed elucidation of cellular travel patterns has provided fundamental knowledge about cells and has enhanced understanding of diseases that arise when bottlenecks impede some of the protein flow. His work earned him one of the most prestigious prizes in science, the 2002 Albert Lasker Award for Basic Medical Research, which he shared with James Rothman. -
Download Ps Nobel Prizes for Site BEE 11.18.16 Revised 11.30.17.Pdf
Nobel Laureates at the College of Physicians and Surgeons For years, College of Physicians and Surgeons alumni, faculty, and researchers have led groundbreaking clinical and basic scientific studies that have transformed our understanding of human biology and advanced the practice of medicine. On many occasions, this work has been honored with the Nobel Prize. The scope of research led by P&S Nobel laureates is tremendous. Although most of our prizewinners were honored for work in physiology or medicine, a few also received the prize for chemistry. Their research has fundamentally shaped the course of numerous fields, including cardiology, neuroscience, genetics, pharmaceutical development, and more. Our Nobel laureates include: André Cournand and Dickinson Richards (P&S’23), whose work at P&S on cardiac catheterization—a method of inserting a tiny tube into the heart—provided the basis for open-heart surgery and interventional cardiology Baruch Blumberg (P&S’51), who discovered the hepatitis B virus and helped develop a test and a vaccine for the virus Joshua Lederberg, a Columbia College and P&S graduate student who showed that bacteria can exchange genes when they reproduce, creating a way to model and study genetics in higher organisms Harold Varmus (P&S’66), who demonstrated how genes in normal human and animal cells can mutate to cause cancer, leading to a new generation of research on the genetic origins of cancer Eric Kandel, current University Professor, who showed how memories are stored in nerve cells, greatly enhancing -
Nobel Prizes in Physiology Or Medicine with an Emphasis on Bacteriology
J Med Bacteriol. Vol. 8, No. 3, 4 (2019): pp.49-57 jmb.tums.ac.ir Journal of Medical Bacteriology Nobel Prizes in Physiology or Medicine with an Emphasis on Bacteriology 1 1 2 Hamid Hakimi , Ebrahim Rezazadeh Zarandi , Siavash Assar , Omid Rezahosseini 3, Sepideh Assar 4, Roya Sadr-Mohammadi 5, Sahar Assar 6, Shokrollah Assar 7* 1 Department of Microbiology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. 2 Department of Anesthesiology, Medical School, Kerman University of Medical Sciences, Kerman, Iran. 3 Department of Infectious and Tropical Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. 4 Department of Pathology, Dental School, Shiraz University of Medical Sciences, Shiraz, Iran. 5 Dental School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. 6 Dental School, Shiraz University of Medical Sciences, Shiraz, Iran. 7 Department of Microbiology and Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. ARTICLE INFO ABSTRACT Article type: Background: Knowledge is an ocean without bound or shore, the seeker of knowledge is (like) the Review Article diver in those seas. Even if his life is a thousand years, he will never stop searching. This is the result Article history: of reflection in the book of development. Human beings are free and, to some extent, have the right to Received: 02 Feb 2019 choose, on the other hand, they are spiritually oriented and innovative, and for this reason, the new Revised: 28 Mar 2019 discovery and creativity are felt. This characteristic, which is in the nature of human beings, can be a Accepted: 06 May 2019 motive for the revision of life and its tools and products. -
Service History July 2012 AGM - September 2018 AGM
Service History July 2012 AGM - September 2018 AGM The information in this Service History is true and complete to the best of The Society’s knowledge. If you are aware of any errors please let the Governance and Risk Manager know by email: [email protected] Service History Index DATES PAGE # 5 July 2012 – 24 July 2013 Page 1 24 July 2013 – 1 July 2014 Page 14 1 July 2014 – 7 July 2015 Page 28 7 July 2015 – 31 July 2016 Page 42 31 July 2016 – 12 July 2017 Page 60 12 July 2017 – 16 September 2018 Page 82 Service History: July 2012 AGM – Sept 2018 AGM Introduction Up until 2006 the service history of The Society’s members was captured in Grey Books. It was also documented between 1990-2013 in The Society’s old database iMIS, which will be migrated to the CRM member directory adopted in 2016. This document collates missing service history data from July 2012 to September 2018. Grey Books were relaunched as ‘Grey Records’ in 2019 beginning with the period from the September AGM 2018 up until July AGM 2019. There will now be a Grey Record published every year reflecting the previous year’s service history. The Grey Record will now showcase service history from Member Forum to Member Forum (typically held in the Winter). 5 July 2012 – 24 July 2013 Honorary Officers (and Trustees) POSITION NAME President Jonathan Ashmore Deputy President Richard Vaughan-Jones Honorary Treasurer Rod Dimaline Education & Outreach Committee Chair Blair Grubb Meetings Committee Chair David Wyllie Policy Committee Chair Mary Morrell Membership & Grants Committee -
Helicobacter Pylori…
Helicobacter pylori… Medical Wisdom Challenged by a Cocktail bacteria clinging to the tissues s that nagging, burning of his biopsy specimens. He feeling in your stomach worked diligently with his Icaused by stress, excess associate, the Australian acid, eating spicy food, or physician Barry Marshall, in maybe your insensitive boss? culturing what they saw under the microscope, but to no Back in 1981, Barry Marshall avail. However during the didn’t think so. His discovery Easter weekend of 1982, they regarding the true cause of inadvertently left their duodenal and gastric ulcers cultures incubating for five has changed the way we think days; and to their surprise Jay Hardy, CLS, SM (ASCP) about this disease forever. In they discovered the colonies fact, Marshall believed in his cause so strongly that, to Jay Hardy is the founder and prove his theory, he drank a CEO of Hardy Diagnostics. bacterial cocktail that made He began his career in him violently ill. But he microbiology as a Medical proved his case; to the benefit Technologist in Santa of millions of people who Barbara, California. suffer from ulcers. In 1980, he began manufacturing culture media It was known as far back as for the local hospitals. 1875 by German scientists Today, Hardy Diagnostics is that a spiral-shaped bacterium the third largest media manufacturer in the U.S. inhabited the lining of the human stomach. However, To ensure rapid and reliable because this organism was turn around time, Hardy impossible to culture at the Diagnostics maintains six time, it was quickly forgotten. distribution centers, and produces over 2,700 products used in clinical and Fast forward to 1979.