EDITORIAL Year's Comments for 2005
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書 名 等 発行年 出版社 受賞年 備考 N1 Ueber Das Zustandekommen Der
書 名 等 発行年 出版社 受賞年 備考 Ueber das Zustandekommen der Diphtherie-immunitat und der Tetanus-Immunitat bei thieren / Emil Adolf N1 1890 Georg thieme 1901 von Behring N2 Diphtherie und tetanus immunitaet / Emil Adolf von Behring und Kitasato 19-- [Akitomo Matsuki] 1901 Malarial fever its cause, prevention and treatment containing full details for the use of travellers, University press of N3 1902 1902 sportsmen, soldiers, and residents in malarious places / by Ronald Ross liverpool Ueber die Anwendung von concentrirten chemischen Lichtstrahlen in der Medicin / von Prof. Dr. Niels N4 1899 F.C.W.Vogel 1903 Ryberg Finsen Mit 4 Abbildungen und 2 Tafeln Twenty-five years of objective study of the higher nervous activity (behaviour) of animals / Ivan N5 Petrovitch Pavlov ; translated and edited by W. Horsley Gantt ; with the collaboration of G. Volborth ; and c1928 International Publishing 1904 an introduction by Walter B. Cannon Conditioned reflexes : an investigation of the physiological activity of the cerebral cortex / by Ivan Oxford University N6 1927 1904 Petrovitch Pavlov ; translated and edited by G.V. Anrep Press N7 Die Ätiologie und die Bekämpfung der Tuberkulose / Robert Koch ; eingeleitet von M. Kirchner 1912 J.A.Barth 1905 N8 Neue Darstellung vom histologischen Bau des Centralnervensystems / von Santiago Ramón y Cajal 1893 Veit 1906 Traité des fiévres palustres : avec la description des microbes du paludisme / par Charles Louis Alphonse N9 1884 Octave Doin 1907 Laveran N10 Embryologie des Scorpions / von Ilya Ilyich Mechnikov 1870 Wilhelm Engelmann 1908 Immunität bei Infektionskrankheiten / Ilya Ilyich Mechnikov ; einzig autorisierte übersetzung von Julius N11 1902 Gustav Fischer 1908 Meyer Die experimentelle Chemotherapie der Spirillosen : Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie / N12 1910 J.Springer 1908 von Paul Ehrlich und S. -
Fleming Vs. Florey: It All Comes Down to the Mold Kristin Hess La Salle University
The Histories Volume 2 | Issue 1 Article 3 Fleming vs. Florey: It All Comes Down to the Mold Kristin Hess La Salle University Follow this and additional works at: https://digitalcommons.lasalle.edu/the_histories Part of the History Commons Recommended Citation Hess, Kristin () "Fleming vs. Florey: It All Comes Down to the Mold," The Histories: Vol. 2 : Iss. 1 , Article 3. Available at: https://digitalcommons.lasalle.edu/the_histories/vol2/iss1/3 This Paper is brought to you for free and open access by the Scholarship at La Salle University Digital Commons. It has been accepted for inclusion in The iH stories by an authorized editor of La Salle University Digital Commons. For more information, please contact [email protected]. The Histories, Vol 2, No. 1 Page 3 Fleming vs. Florey: It All Comes Down to the Mold Kristen Hess Without penicillin, the world as it is known today would not exist. Simple infections, earaches, menial operations, and diseases, like syphilis and pneumonia, would possibly all end fatally, shortening the life expectancy of the population, affecting everything from family-size and marriage to retirement plans and insurance policies. So how did this “wonder drug” come into existence and who is behind the development of penicillin? The majority of the population has heard the “Eureka!” story of Alexander Fleming and his famous petri dish with the unusual mold growth, Penicillium notatum. Very few realize that there are not only different variations of the Fleming discovery but that there are also other people who were vitally important to the development of penicillin as an effective drug. -
Naturvidenskabernes Kanonisering. Forskere, Erkendelser Eller Kulturarv
NORDISK MUSEOLOGI 2006 G 2, S. 27-44 Naturvidenskabernes kanonisering. Forskere, erkendelser eller kulturarv KRISTIAN HVIDTFELT NIELSEN* Title: The ”canonisation” of the natural sciences. Abstract: This paper concerns recent official attempts to place science in Denmark within the context of a cultural canon. Based on differentiation between Mode 1 and 2 knowledge production, the paper points out that such attempts are highly contextualised and contingent on their different modes of application. Consequent- ly, they entangle scientific expertise with other social skills and qualifications. Like science museums and science centres, they are a means of dealing with science in the public agora, i.e. the public sphere in which negotiations, mediations, consulta- tions and contestations regarding science increasingly take place. Analysing the am- biguities and uncertainties associated with the recent official placing of science wit- hin an overall cultural canon for Denmark, this paper concludes that even though the agora embodies antagonistic forms of interaction, it might also lead the way to producing socially robust knowledge about science. Keywords: Cultural canon, science, Mode 1 and 2 knowledge production, Mode 2 society, agora, science museums, science centres. Naturvidenskab er ikke med i den officielle, denskabskanoner samt deres bredere betyd- danske kulturkanon, som blev sat i værk af ning for offentlighedens forståelse af naturvi- Kulturministeriet i 2005 (Kulturministeriet denskab, som jeg i denne artikel vil komme 2006). Det -
Howard-Florey-Maker
_ ....II""lle,st'Ol)' of "Ie lin ~t tlt:Mc 'c y~ successfullY to rmat. pea WIth ~ IJ&. iBfoctiOus'diseases - begins-with &bit Qf IuC AI~ PI tIlil1g, a .S 9itisb ~lientlst.notlcEid In t$!B ftJal mould.,ad l:!"eveAted growth of ~ qerms {bacterial 1., lils ~ the ~In plot 0 me story 1'I0J0IYl1l$ Sr ~pvay Qf penidll 10 ~ years la1er by arl·Aus\ 1;1 Sdetl bam t'!undred s R Y~'89D this year, H'owar~ I: fIotey and h d ~ team's ~ systttma!JQ, detalla wotk "'~ Jl 11_ fJTIed petlicilin from an 53 i[l~1Jlg o~ , nto-a life saver. ' Emma ,au fY 50 IJSOO to tm e teliladll', at t'l'wiMlstral r:Ja • U verslty's JOOf\ CtJrti[l Scbool of Moolaal Rasecll'eh (HQw FJor~ ptayed 8 c roI'a II'l the-est)bllshmflnt at itI& School god ~!lr'S1ty t In h 11M), TIll> !/O"'"_....... ot l!1te.dJ1l1II d1Haie'&."4ICh .. po.~a~1I ~ Erl'1lil"1a's.lile w~!i8Vedby penicillin irllll IIlIaod .. 1111 IIihi' 1111\1:_ tva ~ntil>iol~; 8uI1hft;e phDl Cl(a pauilftl n Get'rJ1art refiJg g mp. tt WQf1d War II. ,1<42 -"ow ho"; b.d thlnP COIH~. Pft_ 1 lind Imagine hO\ she fett any years later. 2 ~ '1M .III~ !It II YOUl1'llll1J1 willi _I J."..,tllltw...... OlIl1dltlicln ,..,_by the tt.iituI t cooid~ blITlping iHlo mtJY wh fa lIay ..fI...boiIJg IIlven penldll" {JItIiJID 3" _ hIld ~ woriled- the man who made tile shown .~"in.IH",p"'-.ntIIIf tbll JIIII!Ilt dllly g~pIy mpooicillin ~bte. -
Sir Howard Florey - Biography
Sir Howard Florey - Biography Sir Howard Florey – Biography The Nobel Prize in Physiology or Medicine Sir Howard Walter Florey was 1945 born on September 24, 1898, at Presentation Speech Adelaide, South Australia, the son Educational of Joseph and Bertha Mary Florey. His early education was at St. Sir Alexander Fleming Peter's Collegiate School, Adelaide, Biography Nobel Lecture following which he went on to Banquet Speech Adelaide University where he Documentary graduated M.B., B.S. in 1921. He Other Resources was awarded a Rhodes Scholarship to Magdalen College, Oxford, Ernst B. Chain leading to the degrees of B.Sc. and Biography M.A. (1924). He then went to Nobel Lecture Cambridge as a John Lucas Walker Banquet Speech Student. In 1925 he visited the United States on a Rockefeller Other Resources Travelling Fellowship for a year, returning in 1926 to a Fellowship at Gonville and Caius College, Cambridge, receiving Sir Howard Florey here his Ph.D. in 1927. He also held at this time the Freedom Biography Research Fellowship at the London Hospital. In 1927 he was Nobel Lecture appointed Huddersfield Lecturer in Special Pathology at Banquet Speech Cambridge. In 1931 he succeeded to the Joseph Hunter Chair of Pathology at the University of Sheffield. 1944 1946 Leaving Sheffield in 1935 he became Professor of Pathology and a Fellow of Lincoln College, Oxford. He was made an The 1945 Prize in: Physics Honorary Fellow of Gonville and Caius College, Cambridge in Chemistry 1946 and an Honorary Fellow of Magdalen College, Oxford in Physiology or Medicine 1952. In 1962 he was made Provost of The Queen's College, Literature Oxford. -
Tierversuche in Der Forschung Senatskommission Für Tierexperimentelle Forschung Der Deutschen Forschungsgemeinschaft Tierversuche in Der Forschung 3 2
Senatskommission für tierexperimentelle Forschung der Deutschen Forschungsgemeinschaft Tierversuche in der Forschung Senatskommission für tierexperimentelle Forschung der Deutschen Forschungsgemeinschaft Tierversuche in der Forschung 2 3 Inhalt Vorwort �� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � 4 Tierversuche und Tierschutz: Ethische Abwägungen Einführung �� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � 6 Die Entwicklung des Tierschutzgedankens in Deutschland �� � � � � � � � � � � � � 39 Ethische Aspekte von Tierversuchen und das Solidaritätsprinzip� � � � � � � � 40 Tierversuche: Definition und Zahlen Die Übertragbarkeit aus ethisch-rechtlicher Sicht� � � � � � � � � � � � � � � � � � � � � � 45 Was ist ein Tierversuch? �� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � 9 Das 3 R-Prinzip �� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � 48 Wie viele Tiere werden verwendet? �� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � 9 Alternativen zum Tierversuch� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � 51 Wofür werden Tiere in der Forschung benötigt? �� � � � � � � � � � � � � � � � � � � � � � 11 Grenzen von Alternativmethoden� � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � � 54 Welche Tierarten werden eingesetzt? �� -
Tierversuche in Der Forschung Senatskommission Für Tierexperimentelle Forschung Der Deutschen Forschungsgemeinschaft Tierversuche in Der Forschung 2 3
Senatskommission für tierexperimentelle Forschung der Deutschen Forschungsgemeinschaft Tierversuche in der Forschung Senatskommission für tierexperimentelle Forschung der Deutschen Forschungsgemeinschaft Tierversuche in der Forschung 2 3 Inhalt Vorwort . 4 Tierversuche und Tierschutz: Ethische Abwägungen Einführung . 6 Die Entwicklung des Tierschutzgedankens in Deutschland . 39 Ethische Aspekte von Tierversuchen und das Solidaritätsprinzip. 40 Tierversuche: Definition und Zahlen Die Übertragbarkeit aus ethisch-rechtlicher Sicht. 45 Was ist ein Tierversuch? . 9 Das 3 R-Prinzip . 48 Wie viele Tiere werden verwendet? . 9 Alternativen zum Tierversuch. 51 Wofür werden Tiere in der Forschung benötigt? . 11 Grenzen von Alternativmethoden. 54 Welche Tierarten werden eingesetzt? . 11 Die Basler Deklaration . 56 Europaweite Entwicklung . 14 Tierversuche in Deutschland: Vom Antrag bis zur Durchführung Tierexperimentelle Praxis: Einsatzbereiche für Versuchstiere Europäische Regelungen für Tierversuche . 59 Grundlagenforschung. 17 Tierversuche unter Genehmigungsvorbehalt . 60 Medizinische Forschung. 18 Rechtliche Grundlagen . 60 Nobelpreiswürdig: Herausragende wissenschaftliche Erkenntnisse . 20 Genehmigungsverfahren . 63 Diagnostik . 22 Durchführung von Tierversuchen . 64 Transplantationsmedizin . 25 Qualifizierte Überwachung. 68 Zell- und Gewebeersatz beim Menschen. 26 Belastungen für die Tiere . 69 Stammzellforschung . 27 Die Tierschutz-Verbandsklage . 71 Genomforschung . 28 Neurowissenschaften . 31 Anhang Veterinärmedizinische Forschung . 33 Tierversuche -
Nobel Prizes in Physiology Or Medicine with an Emphasis on Bacteriology
J Med Bacteriol. Vol. 8, No. 3, 4 (2019): pp.49-57 jmb.tums.ac.ir Journal of Medical Bacteriology Nobel Prizes in Physiology or Medicine with an Emphasis on Bacteriology 1 1 2 Hamid Hakimi , Ebrahim Rezazadeh Zarandi , Siavash Assar , Omid Rezahosseini 3, Sepideh Assar 4, Roya Sadr-Mohammadi 5, Sahar Assar 6, Shokrollah Assar 7* 1 Department of Microbiology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. 2 Department of Anesthesiology, Medical School, Kerman University of Medical Sciences, Kerman, Iran. 3 Department of Infectious and Tropical Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. 4 Department of Pathology, Dental School, Shiraz University of Medical Sciences, Shiraz, Iran. 5 Dental School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. 6 Dental School, Shiraz University of Medical Sciences, Shiraz, Iran. 7 Department of Microbiology and Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. ARTICLE INFO ABSTRACT Article type: Background: Knowledge is an ocean without bound or shore, the seeker of knowledge is (like) the Review Article diver in those seas. Even if his life is a thousand years, he will never stop searching. This is the result Article history: of reflection in the book of development. Human beings are free and, to some extent, have the right to Received: 02 Feb 2019 choose, on the other hand, they are spiritually oriented and innovative, and for this reason, the new Revised: 28 Mar 2019 discovery and creativity are felt. This characteristic, which is in the nature of human beings, can be a Accepted: 06 May 2019 motive for the revision of life and its tools and products. -
Penicillin: World War II Infections and Howard Florey
In Focus Penicillin: World War II infections and Howard Florey The results were dramatic – the control mice rapidly succumbed, while all of the treated mice survived. These results attracted great interest from the scientific and military communities because, if Ian Gust replicated in humans, the drug had the potential to influence the Department of Microbiology and outcome of WWII. Immunology University of Melbourne It took Florey and 16 colleagues several months to produce suffi- Parkville, Vic. 3010, Australia Tel: +61 3 8344 3963 cient material to treat a handful of patients. The team worked under Fax: +61 3 8344 6552 fi fi Email: [email protected] dif cult circumstances with a lack of funding and equipment; at rst penicillin was made using old dairy equipment. Hospital bedpans were later used to grow the mould and the liquid containing fi Howard Florey is celebrated for his major contributions to penicillin drained from beneath the growing mould and ltered the large-scale production of the fungal product, penicillin, through parachute silk. during World War II (WWII), leading to life-saving outcomes The first patient they treated was a policeman, in whom an infected for many more than those with war wounds. scratch had developed into a life threatening infection. He was given Howard Florey was born in South Australia in 1898. After studying penicillin, and within a day began to recover. Unfortunately Florey’s medicine at the University of Adelaide he was awarded a Rhodes team only had sufficient drug for 5 days of treatment and when Scholarship to work in Oxford under Sir Charles Sherrington. -
Illustrations from the Wellcome Institute Library the Chain Papers*
Medical History, 1983, 27:434-435 ILLUSTRATIONS FROM THE WELLCOME INSTITUTE LIBRARY THE CHAIN PAPERS* THE three men who shared the Nobel Prize in October 1945 for their work on penicillin could scarcely have differed more in their backgrounds and characters. Fleming was sixty-four years old by then; the son of a Scottish farmer, he was a retiring man, not given to conversation. By contrast, Florey, then aged forty-seven, was the son of a wealthy Australian boot and shoe manufacturer; aggressively ambitious, his achievements and intellect were later to secure him the Presidency of the Royal Society. Then there was Chain - a mere thirty-nine years old - a Jewish refugee of Russian origin, who still had major work on penicillin ahead of him; his ambition was mixed with an independence and volubility that was to lead him into conflict with the scientific/medical establishment. Fleming has been the subject of many biographies, mostly hagiographical. Florey's role in the penicillin story was recently reassessed in Gwyn Macfarlane's excellent Howard Florey. The making ofa great scientist (Oxford University Press, 1979). Sir Ernst Boris Chain died in 1979, and his biography is being written by Ronald W. Clark. This, together with future research on Chain's papers, will enable a fuller assessment to be made of the role and character of the youngest of the three scientists. The Chain papers, recently given by Lady Chain to the Contemporary Medical Archives Centre, form an extensive collection of some sixty-nine boxes, comprising material from Chain's personal and professional life. -
Speaker's Manuscript
Nobel Prize Lessons 2018 Speaker’s manuscript – the 2018 Medicine Prize The Nobel Prize in Physiology or Medicine • The Nobel Prize in Physiology or Medicine is one of the five prizes founded by Alfred Nobel and awarded on December 10 every year. Before Alfred Nobel died on December 10, 1896, he wrote in his will that the largest part of his fortune should be placed in a fund. The yearly interest on this fund would pay for a prize given to “those who, during the preceding year, shall have conferred the greatest benefit to humankind.” Who is rewarded with the Medicine Prize? • The Nobel Prize in Physiology or Medicine is thus awarded to people who have either made a discovery about how organisms work or have helped find a cure for a disease. • This is May-Britt Moser, 2014 Nobel Laureate in Medicine. In 2005 she and Edvard Moser discovered a type of cell in the brain that is important for determining one's position. They also found that those cells cooperate with different nerve cells in the brain that help us to navigate. You can say that the Laureates discovered and explained a kind of GPS system in the brain. • Other Medicine Laureates include: • Francis Crick, James Watson and Maurice Wilkins, who received the 1962 Prize for their discoveries and descriptions about the structure of DNA molecules. • Alexander Fleming, Ernst Chain and Howard Florey, who received the 1945 Prize for the discovery of penicillin and its curative effects on bacterial diseases. Medicine Prize 2018 • The 2018 Nobel Prize is about a new way of treating cancer. -
The Fascinating Germ Theories on Cancer Pathogenesis G
JBUON 2014; 19(1): 319-323 ISSN: 1107-0625, online ISSN: 2241-6293 • www.jbuon.com E-mail: [email protected] HISTORY OF ONCOLOGY The fascinating germ theories on cancer pathogenesis G. Tsoucalas1, K. Laios1, M. Karamanou1, V. Gennimata2, G. Androutsos1 1Department of History of Medicine, Medical School, University of Athens, Athens; 2Department of Microbiology, Medical School, University of Athens, Athens, Greece Summary bel Prize in 1926 that was attributed to the Danish scientist Johannes Fibiger for his work on the nematode Spiroptera as a For more than 100 years, the germ theory of cancer, pro- causative agent in cancer. Even if those theories were the result posing that microorganisms were at the origin of the disease, of fantasy and misinterpretation, they paved the way for the dominated medicine. Several eminent scientists like Etienne scientific research in oncology. Burnet, Mikhail Stepanovich Voronin, Charles-Louis Mal- assez, and Francis-Peyton Rous argued on the pathogenesis presenting their theories that implicated cocci, fungi and par- Key words: carcinogenesis, germ theories, Johannes Fibiger, asites. The impact of these theories was culminated by the No- parasitic theory Introduction transmission was explained. It is long discussed for cancer that heredity is a legend that will vanish Apart from the exogenous, strange for today’s when contagion will be proved” [1]. medical world, misconceptions about cancer (can- cer villages, cancer houses, cancer countries, can- The germs of cancer: coccus and fungi cer races), the microbial theory of cancer held a significant place in the scientific community dur- Several scientists believed that cancerous ing the second half of the 19th century, similarly to germ had a preference for wetlands and could be tuberculosis during the previous decades.