DOCSLIB.ORG

Transient Gene Expression in HEK293 Cells

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Transient Gene Expression in HEK293 Cells ORGANOTECHNIE PEPTONES to Enhance Protein Expression in Mam malian Cell Lines Peptones selected by The Scientific Community and The Industry : TRYPTONE N1 TRYPTONE PLUS New C-Cell Peptones for Mammalian Cell Lines : MICROFILTERED BATCH SELECTED THROUGH OUR OWN PERFORMANCE TEST BASED ON MAMMALIAN CELL LINES ULTRAFILTERED PROTEIN FREE (0 % > 10 KDA) HIGH TITER Protein Expression in Mammalian Cell Lines HEK 293 CHO REFERENCES “Transient Gene Expression in HEK293 Cells: Peptone Addition Posttransfection Improves Recombinant Protein Synthesis”, ANIMAL CELL TECHNOLOGY GROUP SECTOR, BIOTECHNOLOGY RESEARCH INSTITUTE, NATIONAL RESEARCH COUNCIL, MONTREAL (CANADA), BIOTECHNOLOGY AND BIOENGINEERING, VOL. 90, N°3, MAY 2005 P.L. Pham S. Perret B. Cass E. Carpentier G. St-Laurent L. Bisson A. Kamen Y. Durocher ‘‘Encyclopedia of Cell Biology’’, UNIVERSITY OF CALIFORNIA (USA), WASHINGTON UNIVERSITY SCHOOL OF MEDICINE (USA), JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE, BALTIMORE (USA), ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE, NORTH CHICAGO (USA), PENN STATE UNIVERSITY COLLEGE OF MEDICINE, HERSHEY (USA); MOLECULAR CELL BIOLOGY ELSEVIER (I) 54-65, 2016 Ralph A. Bradshaw Philip D. Stahl ‘‘H-IPSE Is a Pathogen-Secreted Host Nucleus-Infiltrating Protein (Infiltrin) Expressed Exclusively by the Schistosoma haematobium Egg Stage’’, STANFORD UNIVERSITY SCHOOL OF MEDICINE, CALIFORNIA (USA), SCHOOL OF PHARMACY, UNIVERSITY OF NOTTINGHAM (UK), BIOMEDICAL RESEARCH INSTITUTE, MARYLAND (USA), AMERICAN SOCIETY FOR MICROBIOLOGY INFECTION AND IMMUNITY, SEPTEMBER 2017 Luke F. Pennington Abdulaziz Alouffi Evaristus C. Mbanefo Debalina Ray David M. Heery Theodore S. Jardetzky Michael H. Hsieh Franco H. Falcone ‘‘Expression of antibodies using single open reading frame (sORF) vector design’’, ABBVIE, WORCESTER, MA USA, MABS 5:4, 595-607 LANDES BIOSCIENCE, JULY/AUGUST 2013 Wendy R. Gion Rachel A. Davis-Taber Dean A. Regier Emma Fung Limary Medina Ling C. Santora Sahana Bose Alexander V. Ivanov Barbara A. Perilli-Palmer Chris M. Chumsae Joseph G. Matuck June Z. Kunes Gerald R. Carson ‘‘Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles’’, BIOTECHNOLOGY RESEARCH CENTER, PASTEUR INSTITUTE OF IRAN, TEHRAN; SCIENCE AND RESEARCH BRANCH, ISLAMIC AZAD UNIVERSITY OF ARAK, IRAN, IRANIAN BIOMEDICAL JOURNAL (IBJ), 19(4), 194-205, OCTOBER 2015 Fatemeh Davami Farnaz Eghbalpour Leila Nematollahi Farzaneh Barkhordari Fereidoun Mahboudi ‘‘Effect of Peptone Feeding on Transient Gene Expression Process in CHO DG44’’, BIOTECHNOLOGY RESEARCH CENTER, PASTEUR INSTITUTE OF IRAN, TEHRAN; SCIENCE AND RESEARCH BRANCH, ISLAMIC AZAD UNIVERSITY OF ARAK, IRAN, AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 6(3), 147-155, MARCH 2014 Fatemeh Davami Farnaz Eghbalpour Leila Nematollahi Farzaneh Barkhordari Fereidoun Mahboudi ‘‘Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells’’, LABORATORY OF CELLULAR BIOTECHNOLOGY, ECOLE POLYTECHNIQUE FÉDERALE DE LAUSANNE, SWITZERLAND BIOTECHNOLOGY RESEARCH CENTER, PASTEUR INSTITUTE OF IRAN, INT J MOL CELL MED, 3, AUGUST 2014 Fatemeh Davami Lucia Baldi Yashas Rajendra Florian M. Wurm ‘‘High level transient production of recombinant antibodies and antibody fusion proteins in HEK 293 cells’’, DEPARTMENT OF BIOTECHNOLOGY, TECHNISCHE UNIVERSITÄT BRAUNSCHWEIG, INSTITUTE OF BIOCHEMISTRY, BIOTECHNOLOGY AND BIOINFORMATICS, GERMANY; BIOMED CENTRAL (BMC) BIOTECHNOLOGY 13, 52, 1472-6750, 2013 Volker Jäger Konrad Büssow Andreas Wagner Susanne Weber Michael Hust André Frenzel Thomas Schirrmann ‘‘Transient production of scFv-Fc fusion proteins in mammalian cells’’, TECHNISCHE UNIVERSITÄT BRAUNSCHWEIG, INSTITUT FÜR BIOCHEMIE UND BIOTECHNOLOGIE, DEPARTMENT OF BIOTECHNOLOGY, GERMANY; ANTIBODY ENGINEERING, VOLUME II, 2010 Thomas Schirrmann Konrad Büssow ‘‘A robust transfection reagent for the transfection of CHO and HEK 293 cells and production of recombinant proteins and lentiviral particles – PTG1’’, BIOTECHNOLOGY JOURNAL SYSTEMS & SYNTHETIC BIOLOGY NANOBIOTECH MEDICINE; SEPTEMBER 2014 Cristine Gonçalves Fabian Gross Philippe Guégan Hervé Cheradame Patrick Midou ‘‘High-titer expression of recombinant antibodies by transiently transfected HEK 293-6E cell cultures’’, RECOMBINANT PROTEIN EXPRESSION GROUP, HELMHOLTZ CENTRE FOR INFECTION RESEARCH, GERMANY; BIOMED CENTRAL (BMC) PROCEEDINGS, 9, 40, DECEMBER 2015 Volker Jäger Johanna Groenewold Dominik Krüger Dennis Schwarz Veith Vollmer ‘‘Optimization of recombinant protein expression in HEK 293 cell line’’, UNIVERZITA KARLOVA V PRAZE, PRIRODOVEDECKA FAKULTA, KATEDRA BIOCHEMIE, FACULTAS RERUM NATURALIUM, 2010 Jan Blaha ‘‘Pyroglutamate and O-Linked Gycan Determine Functional Production of Anti-IL17A and Anti-IL22 Peptide-Antibody Bispecific Genetic Fusions’’, PFIZER BIOTHERAPEUTICS RESEARCH AND DEVELOPMENT, CAMBRIDGE, MASSACHUSETTS AND PFIZER COVX RESEARCH, SAN DIEGO, CALIFORNIA, JBC PAPERS IN PRESS, NOVEMBER 2012 Xiaotian Zhong Elizabeth Kieras Eric Sousa Aaron D’Antona J. Christian Baber Tao He Joel Desharnais Lauren Wood Deborah Luxenberg Mark Stahl Ronald Kriz Laura Lin Will Somers Lori J. Fitz Jill F.Wright Patent No. US 9,217,039 B2, ‘‘Anti-HER3 Antibodies and Compositions’’, SYMPHOGEN A/S, LYNGBY (DK), DECEMBER 2015 Mikkel Wandahl Pedersen Helle Jacobsen Klaus Koefoed Patent No. US 2017/0029515 A1, ‘‘Method of Inhibition of Leukemic STEM Cells’’, CSL LIMITED, PERKVILLE, VI (US), UNIVERSITY HEALTH NETWORK, TORONTO (CA), FEBRUARY 2017 John Edgar Dick Liqing JIN Gino Luigi Vairo David Paul Gearing Samantha Jane Busfield Patent No. US 2016/0222356 A1, ‘‘High Titer Recombinant AAV Vector Production in Adherent and Suspension Cells’’, AMGEN INC., THOUSAND OAKS, CA (US), AUGUST 2016 Huiren Zhao Ki Jeong Lee Thomas Wolfe Cherylene Plewa Jackie Z. Sheng ‘‘Rôle des Protéoglycanes à Héparane Sulfate dans le Transfert de Gène des Cellules CHO et HEK 293’’, MONTREAL UNIVERSITY, DEPARTEMENT DE BIOCHIMIE ET DE MEDECINE MOLECULAIRE, MAY 2016* *THESIS AVAILABLE ONLY IN FRENCH Laurence Delafosse ‘‘Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil’’, MONTREAL UNIVERSITY, DEPARTEMENT DE BIOCHIMIE ET DE MEDECINE MOLECULAIRE, FACULTE DE MEDECINE, JUNE 2015* *THESIS AVAILABLE ONLY IN FRENCH Elodie Louvier ‘‘Single Chain Antibodies as Tools to Study transforming growth factor-β-Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens”, DEPT. OF IMMUNOLOGY, UPPSALA UNIVERSITY, SWEDEN, MOLECULAR & CELLULAR PROTEOMICS, FEBRUARY 2016 Andries Blokzijl Agata Zieba Michael Hust Thomas Schirrmann Saskia Helmsing Karin Grannas Ellen Hertz Anita Moren Lei Chen Ola Soderberg Aristidis Moustakas Stefan Dubel Ulf Landegren ‘‘An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease”, TEVA PHARMACEUTICALS, R&D, BIOLOGICS, LEAD ANTIBODY DISCOVERY, SYDNEY, AUSTRALIA; TEVA PHARMACEUTICALS, R&D, BIOLOGICS, ASSAYS AND TECHNOLOGY, TAYLOR & FRANCIS GROUP, LLC © TEVA PHARMACEUTICALS AUSTRALIA PTY LTD, 2018 Adam W.Clarke Lynn Poulton Doris Shim David Mabon Danyal Butt Matthew Pollard Vanya Pande Jean Husten Jacquelyn Lyons Chen Tian & Anthony G. Doyle ‘‘A Cyclic Peptidic Serine Protease Inhibitor: Increasing Affinity by Increasing Peptide Flexibility”, DANISH-CHINESE CENTRE FOR PROTEASES AND CANCER, FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER, CHINESE ACADEMY OF SCIENCES, FUZHOU, CHINA; DANISH-CHINESE CENTRE FOR PROTEASES AND CANCER, DEPARTMENT OF MOLECULAR BIOLOGY AND GENETICS, AARHUS UNIVERSITY, DENMARK; NANOSCIENCE CENTER AND DEPARTMENT OF CHEMISTRY, UNIVERSITY OF AARHUS, DENMARK; DEPARTMENT OF CHEMISTRY, FACULTY OF SCIENCE, UNIVERSITY OF COPENHAGEN, DENMARK; PLOS ONE 9(12):E115872, 2014 Baoyu Zhao Peng Xu Longguang Jiang Berit Paaske Tobias Kromann-Hansen Jan K. Jensen Hans Peter Sorensen Zhuo Liu Jakob T. Nielsen Anni Christensen Masood Hosseini Kasper K. Sorensen Niels Christian Nielsen Knud J. Jensen Mingdong Huang Peter A. Andreasen Patent No. CA2614039A1, “Compositions and methods of treating disease with fgfr fusion proteins”, FIVE PRIME THERAPEUTICS INC., 2015 Lewis T. Williams Elizabeth Bosch Stephen Doberstein Kevin Hestir Diane Hollenbaugh Ernestine Lee Minmin Qin Ali Sadra Justin Wong Ge Wu Hongbing Zhang “Transfection of HEK293-EBNA1 Cells in Suspension with Linear PEI for Production of Recombinant Proteins”, NATIONAL RESEARCH COUNCIL CANADA, COLD SPRING HARBOR PROTOCOLS, 2008 Roseanne Tom Louis Bisson Yves Durocher “Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite”, DEPARTMENT OF IMMUNOLOGY AND INFECTIOUS DISEASES, HARVARD; T.H. CHAN SCHOOL OF PUBLIC HEALTH, BOSTON, USA; DEPARTMENT OF BIOLOGICAL ENGINEERING, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, USA, Nature communications, 2015 Selasi Dankwa Caeul Lim Amy K. Bei Rays H.Y. Jiang James R. Abshire Saurabh D. Patel Jonathan M. Goldberg Yovany Moreno Maya Kono Jacquin C. Niles Manoj T. Duraisingh “Development of Human-Like scFv-Fv Neutralizing Botulinum Neurotoxin E. “, TECHNISCHE UNIERSITAT BRAUNSCHWEIG, INSTITUT FUR BIOCHEMIE, BIOTECHNOLOGIE UND BIOINFORMATIK, ABTEILUNG BIOTECHNOLOGIE, BRAUNSCHWEIG, GERMANY; DIVISION OF BACTERIOLOGY, NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL (NIBSC), UK, INSTITUT DE RECHERCHE BIOMEDICALE DES ARMEES, FRANCE; PLOS ONE, 2015 SEBASTIAN MIETHE Christine
Load more

Recommended publications
  • KANSAS ALUMNI MAGAZINE3 a Hot Tin Roof
    VOL. 69 TVo. 4 KANSAMAGAZINS ALUMNE I \ •Jl THE FLYING JAYHAWKS AND ALUMNI HOLIDAYS PRESENT CRUISE THE PASSAGE OF PETER THE GREAT AUGUST 1 - AUGUST 14, 1991 Now, for the first time ever, you can follow in the historic pathways of Peter the Great, the powerful Russian czar, as you cruise from Leningrad, Peter's celebrated capital and "window on the West," all the way to Moscow ... on the waterways previously accessible only to Russians. See the country as Peter saw it, with its many treasures still beautifully preserved and its stunning scenery virtually untouched. Come join us as we explore the Soviet Union's bountiful treas- ures and traditions amidst today's "glasnost" and spirit of goodwill. From $3,295 per person from Chicago based on double occupancy CRUISE GERMANY'S MAGNIFICENT EAST ON THE ELBE JULY 27 - AUGUST 8, 1991 A new era unfolds ... a country unites ... transition is underway in the East ... Germany's other great river, The Elbe, beckons for the first time in 45 years! Be a part of history! This landmark cruise is a vision that has taken years to realize. Reflected in the mighty Elbe's tranquil waters are some of the most magnificent treasures of the world: renaissance palaces, spired cathedrals, ancient castles ... all set amidst scenery so beautiful it will take your breath away! Add to this remarkable cruise, visits to two of Germany's favorite cities, Hamburg and Berlin, and the "Golden City" of Prague, and you have a trip like none ever offered before. From $3,795 per person from Chicago based on double occupancy LA BELLE FRANCE JUNE 30-JULY 12, 1991 There is simply no better way to describe this remarkable melange of culture and charm, gastronomy and joie de vivre.
    [Show full text]
  • Rodeffer Family
    RODEFFER FAMILY OF ROCKINGHANl COUNTY, VIRGINIA .A.. RECORD OF -rHE DESCENI)A~TS OF CO~RAD Ai\D NANCY ~HQ\\'! AL1~ER ROI)EFFER 1805--19.J.8 Publ?°shecl by CARRIE RODEFFER POWER UNDERvVRITERS ---o--- l\IRS. SALLIE R. ROLSTON :MRS. ZELLA R. FA"CLK BENJAl\tIIN SAMUEL RODEFFER GEORGE CONRAD RODEFFER CHARLES CEPHAS RODEFFER JOSEPH SAlVIUEL RODEFFER :MOFFET F. LONG COPYRIGHTED, 1948, BY CAIU!IE RODEFFER POWER P,·i,,ted l>y SHE?-;A~OOAH PRESS DAYTOX, YIGRINIA 1948 CARRIE RODEFFER POWER The Autho1·-61.; CONTENTS 1. Dedication . .. .. .. .. .. .. ... .. v 2. Fore,vord . .. ... .. .. .. ... .. ........ .. .. .......... ... .. ... ....... ... .. ...... vi 3. From the Rhine to the Shenandoah . .. .. .. .. 1 4. Oath of Allegiance .............................................. 16a 5. The Rodeffers in Pennsylvania Records . .. .. .. 17 6. Name Changes and Variations . .. .. .. .. .. .. .. .. .. 19 7. The Sho\\"alters· . .. .. .. .. .. .. .. .. .. .. .. .. .. .. 21 8. William Rodehafer ..................................................... 23 9. Other Rodeff er Connections ....................................... 25 10. George Rodeffer ........................................................ 25 11. John Rodefer, Sr........................................................ 26 12. The Shenandoah Rodeff ers . .. .. .. .. .. .. .. .. .. ... .. 26 13. Other Gern1an Immigrants ...................................... 28 14. Explanation of Listings .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. 30 15. Genealogical Record .. .. .. .. .. .. .. .......................
    [Show full text]
  • 2014-2015 Course Catalog (PDF)
    John Wood Community College Your college, for your life. jwcc.edu Catalog and Student Handbook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able of Contents Telephone Directory ...........................................................................................................
    [Show full text]
  • 2009 – ISVC 09 Symposium Program
    (ISVC09) International Symposium on Visual Computing Nov 30 - Dec 2, 2009, Las Vegas, Nevada, USA th 5 Contents SYMPOSIUM OVERVIEW ...................................................................................................................................2 MONDAY, NOVEMBER 30th ...............................................................................................................................3 TUESDAY, DECEMBER 1st ...............................................................................................................................5 WEDNESDAY, DECEMBER 2nd .........................................................................................................................7 POSTER SESSION .............................................................................................................................................9 Steering Committee/Area Chairs ....................................................................................................................13 Keynote Speakers ............................................................................................................................................14 International Program Committee ..................................................................................................................14 Special Tracks …………………………………………………………………………………………………………,.20 SPONSORS .......................................................................................................................................................24 1 Final
    [Show full text]
  • Former Fellows Biographical Index Part
    Former Fellows of The Royal Society of Edinburgh 1783 – 2002 Biographical Index Part One ISBN 0 902 198 84 X Published July 2006 © The Royal Society of Edinburgh 22-26 George Street, Edinburgh, EH2 2PQ BIOGRAPHICAL INDEX OF FORMER FELLOWS OF THE ROYAL SOCIETY OF EDINBURGH 1783 – 2002 PART I A-J C D Waterston and A Macmillan Shearer This is a print-out of the biographical index of over 4000 former Fellows of the Royal Society of Edinburgh as held on the Society’s computer system in October 2005. It lists former Fellows from the foundation of the Society in 1783 to October 2002. Most are deceased Fellows up to and including the list given in the RSE Directory 2003 (Session 2002-3) but some former Fellows who left the Society by resignation or were removed from the roll are still living. HISTORY OF THE PROJECT Information on the Fellowship has been kept by the Society in many ways – unpublished sources include Council and Committee Minutes, Card Indices, and correspondence; published sources such as Transactions, Proceedings, Year Books, Billets, Candidates Lists, etc. All have been examined by the compilers, who have found the Minutes, particularly Committee Minutes, to be of variable quality, and it is to be regretted that the Society’s holdings of published billets and candidates lists are incomplete. The late Professor Neil Campbell prepared from these sources a loose-leaf list of some 1500 Ordinary Fellows elected during the Society’s first hundred years. He listed name and forenames, title where applicable and national honours, profession or discipline, position held, some information on membership of the other societies, dates of birth, election to the Society and death or resignation from the Society and reference to a printed biography.
    [Show full text]
  • PATENTES2420.Pdf
    Revista da Propriedade Industrial Nº 2420 23 de Maio de 2017 Patentes Seção VI REPÚBLICA FEDERATIVA DO BRASIL Presidente Michel Temer MINISTÉRIO DA INDÚSTRIA, COMÉRCIO EXTERIOR E SERVIÇOS Ministro da Indústria, Comércio Exterior e Serviços Marcos Pereira INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL Presidente Luiz Otávio Pimentel De conformidade com a Lei nº 5.648 de 11 de dezembro de 1970, esta é a publicação oficial do Instituto Nacional da Propriedade Industrial, órgão vinculado ao Ministério da Indústria, Comércio Exterior e Serviços, República Federativa do Brasil, que publica todos os seus atos, despachos e decisões relativos ao sistema de propriedade industrial no Brasil, compreendendo Marcas e Patentes, bem como os referentes a contratos de Transferência de Tecnologia e assuntos correlatos, além dos que dizem respeito ao registro de programas de computador como direito autoral. As established by Law nº 5.648 of december 11, 1970, this is the official publication of the National Institute of Industrial Property, an office under the Ministry of Industry, Foreign Trade and Services, Federative Republic of Brazil, which publishes all its official acts, orders anddecisions regarding the industrial property system in Brazil, comprising Trademarks and Patents, as well as those refering to Technology Transfer agreements and related matters, besides those regarding software registering as copyright. D´après la Loi nº 5.648 du 11 décembre 1970, cellesi est la publication officielle de I'Institut National de la Propriété Industrielle, unoffice lié au Ministère de I’Industrie, du Commerce Extérieur et des Services, République Fédérative du Brésil, qui publie tous ses actes,ordres et décisions concernant le système de la propriété industrielle au Brésil, y compris marques et brevets, aussi que ceuxréférents aux contracts de transfert de technologie et des sujets afférents, en outre que ceux se rapportant à l'enregistrement desprogrammes d ´ordinateur comme droit d'auteur.
    [Show full text]
  • Yale Medicine Magazine
    yale medicine A fallen student’s Paul MacLean’s A Yale alumna in autumn 2008 endearing legacy triune brain theory the rain forest 4 16 30 A huge nih grant boosts bench-to-bedside research, but many scientists still want to follow their noses 18 yale medicine autumn 2008 CONTENTS on the cover 2 Letters Illustration by Jeffrey Fisher 4 Chronicle 8 Rounds 10 Findings 12 Books & Ideas 16 Capsule 18 Mapping the future of medicine With its largest grant ever, Yale is assembling resources to help clinical scientists focus on ideas—and leave the red tape to others. By Jill Max 24 Is the straight road too narrow? Demands for cures and a flat NIH budget are putting pressure on scientists to produce findings that go right to the bedside. Still, there’s value in finding what you’re not looking for. By Pat McCaffrey 30 A life’s work in Indonesia Even as a medical student, Kinari Webb knew where she wanted to practice medicine. Now, she and her ecologist husband are working to bring health care to Borneo— while preserving the rain forest. By Jill Max 35 Faculty 38 Students 46 Alumni 62 In Memoriam 64 Follow-Up 64 Archives 65 End Note On the Web yalemedicine.yale.edu On our website, readers can submit class notes or a change of address, check the alumni events calendar, arrange for a lifelong Yale e-mail alias through the virtual Yale Station and search our electronic archive. 2 letters We should expect our yale medicine students to be literate Alumni Bulletin of the Yale University School of Medicine It was with some sadness that I Autumn 2008, Volume 43, No.
    [Show full text]
  • Leadership Innovation Impact Annual Report 20 20
    LEADERSHIP INNOVATION ANNUAL 20 IMPACT REPORT 20 TABLE OF CONTENTS 04 Letter from the President 06 2021-2022 Governing Council 08 Organizational Chart 09 Commitment to Racial Equity 11 Program Highlights 12 RESPONDING TO CRITICAL & PRESSING ISSUES 12 / Mobilizing to Counter COVID-19 14 / Confronting the U.S. Opioid Epidemic 16 / Championing Clinician Well-Being & Resilience 18 / Human Germline Genome Editing 20 / Climate Change & Human Health 22 / Preparing for Seasonal and Pandemic Influenza 23 ADVISING THE NATION & THE WORLD ON HEALTH & HEALTH CARE 23 / NAM Leadership Consortium 28 / Advancing Health Equity 30 / Vital Directions in Health & Health Care 32 / The Future of Nursing 33 LEADING & INSPIRING FOR THE FUTURE 33 / Healthy Longevity Global Grand Challenge 35 / Committee on Emerging Science, Technology, and Innovation (CESTI) 36 / Global Health Leadership 37 / NAM Perspectives 39 Member Highlights 40 / Members Elected in 2019 43 / Members Elected in 2020 46 / 2020 Nobel Laureates 47 / 2020 Annual Meeting 49 / The IOM/NAM Anniversary Celebration 50 / In Memoriam 51 Fellowships & Leadership Programs 57 Awards 62 Finances 64 Donor Appreciation 75 Contact Us LETTER FROM THE PRESIDENT Responding to COVID-19 At the outset of 2020, the NAM was preparing to celebrate the 50th anniversary of the founding of the Institute of Medicine (IOM) and the 5th anniversary of IOM’s reconstitution as the NAM. Then, the COVID-19 global pandemic struck. By June 2021, the virus had claimed about 3.5 million lives worldwide and infected over 170 million people. Beyond creating an unprecedented health crisis, the pandemic has threatened the global economy, political stability, and social structure.
    [Show full text]
  • Front Matter
    MOLECULAR AND CELLULAR BIOLOGY VOLUME 3 * NUMBER 12 * DECEMBER 1983 Aaron J. Shatkin, Editor in Chief (1985) Roche Institute of Molecular Biology Nutley, N.J. Harvey F. Lodish, Editor (1986) Louis Siminovitch, Editor (1985) Massachusetts Institute of Technology Hospital for Sick Children Cambridge, Mass. Toronto, Canada David J. L. Luck, Editor (1987) Paul S. Sypherd, Editor (1985) Rockefeller University University of California New York, N.Y. Irvine, Calif. EDITORIAL BOARD Renato Baserga (1985) Ira Herskowitz (1984) Daniel B. Rifkin (1985) Alan Bernstein (1984) Larry Kedes (1985) Robert G. Roeder (1985) J. Michael Bishop (1984) Marilyn Kozak (1985) James E. Rothman (1984) Joan Brugge (1985) Elias Lazarides (1985) Phillip A. Sharp (1985) Breck Byers (1985) John B. Little (1985) Fred Sherman (1985) John A. Carbon (1984) William F. Loomis, Jr. (1985) Pamela Stanley (1985) Lawrence A. Chasin (1985) Paul T. Magee (1985) Joan A. Steitz (1985) Nam-Hai Chua (1985) Robert L. Metzenberg (1985) James L. Van Etten (1985) Terrance G. Cooper (1984) Robert K. Mortimer (1985) Jonathan R. Warner (1984) James E. Darneil, Jr. (1985) Harvey L. Ozer (1985) Robert A. Weinberg (1984) Gary Felsenfeld (1985) Mary Lou Pardue (1985) I. Bernard Weinstein (1985) Norton B. Gilula (1985) Mark Pearson (1985) Harold Weintraub (1985) James E. Haber (1984) Jeremy Pickett-Heaps (1985) Reed B. Wickner (1985) Benjamin Hall (1985) Robert E. Pollack (1985) Leslie Wilson (1985) Ari Helenius (1984) Keith R. Porter (1985) Edward Ziff (1985) Susan A. Henry (1985) John R. Pringle (1985) Helen R. Whiteley, Chairman, Publications Board Walter G. Peter Ill, Director, Publications Linda M. Illig, Managing Editor, Journals Eleanor S.
    [Show full text]
  • ! ! ! ! ! ! Appendix!F:!Cvs! Robert S
    ! ! ! ! ! ! Appendix!F:!CVs! Robert S. Allison, P. Eng. Associate Professor Department of Electrical Engineering and Computer Science Centre for Vision Research York University Contact Address: 4700 Keele St., Toronto, Ontario, Canada, M3J 1P3 Office: CSB 3051 Tel: +1 416-736-2100 x20192 Fax: +1 416-736-5872 email: [email protected] Degrees Ph.D., York University, Biology, 1998 M.A.Sc., University of Toronto, Electrical and Computer Engineering, 1994 B.A.Sc., University of Waterloo, Computer Engineering, Management Sciences Option, 1991 Employment History 2004 – present Associate Professor, Department of Electrical Engineering and Computer Science, York University, Toronto, Ontario • Graduate Program in Psychology • Graduate Program in Computer Science and Engineering • Neuroscience Graduate Diploma Program • Cognitive Science Program 2001 – 2004 Assistant Professor, Department of Computer Science, York University, Toronto, Ontario • Graduate Program in Psychology • Graduate Program in Computer Science and Engineering • Adjunct Member, Graduate Program in Optometry and Vision Science, University of Waterloo 1998 – 2000 Postdoctoral Fellow, Department of Computer Science, York University, Toronto, Ontario 1994 – 1998 Project Scientist, Human Performance Laboratory, Centre for Research in Earth and Space Technology, Toronto, Ontario (part-time until 1998) 1991 – 1992 Electrical Engineer, Atlantis Aerospace Corp., Brampton, Ontario 1988 – 1990 Hardware Engineer (Co-op Student), Bell Northern Research, Nepean, Ontario 1990 Project Engineer
    [Show full text]
  • Barcelona Conference on Epigenetics and Cancer
    International Center B·DEBATE for Scientific Debate BARCELONA Synopsis BEYOND CANCER GENOMES BARCELONA CONFERENCE ON EPIGENETICS AND CANCER October, 13th and 14th, 2016 COSMOCAIXA BARCELONA. ISAAC NEWTON, 26. BARCELONA ORGANIZED BY: WITH THE COLLABORATION OF: SUPPORTED BY: SPONSORED BY: CANCER BEYOND THE GENOME Nowadays there are very few doubts as to the fundamental role genes play in the onset and spread of cancer. Nevertheless, just reading the letters they are made up of1 doesn't seem to be enough to fully understand it. Epigenetics, the study of hereditary changes that are not dependent on the DNA sequence, is shaping up to be key in rounding out the landscape, because it explains how it is regulated and organized. This field has allowed scientists to observe the genome not as a linear book but as a 3-D pop-up, with regulatory sequences, switches and long-distance relationships. Plus, it has helped explain the phenomena of cancer stem cells, which are key cells that seem to start the process and resist chemotherapy. In fact, the latest studies show that many cancerous mutations are found not in genes but in the regions that regulate them, what has been called the dark genome. And several promising treatments are being developed based on these discoveries. A group of top experts from around the world came together on 13 and 14 October 2016 to discuss some of the latest, most important advances in this arena at the debate ‘Beyond Cancer Genomes. Barcelona Conference on Epigenetics and Cancer’, organized by B·Debate – an initiative of Biocat and the “la Caixa” Foundation to promote scientific debate – with the Institute for Research in Biomedicine (IRB Barcelona), and collaboration from the Molecular Biology Institute of Barcelona (CSIC), Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Cancer Epigenetics and Biology Program (PEBC; IDIBELL) and Center for Genomic Regulation (CRG).
    [Show full text]
  • Meeting Global Challenges: Discovery and Innovation
    Meeting Global Challenges: Discovery and Innovation AAAS ANNUAL REPORT 2014 The American Association for the Advancement of Science (AAAS) is the world’s largest general scienti c society and publisher of the journal Science (www.sciencemag.org) as well as Science Translational Medicine (www.sciencetranslationalmedicine.org), Science Signaling (www.sciencesignaling.org), and a digital, open-access journal, Science Advances (www.scienceadvances.org). AAAS was founded in 1848 and includes nearly 250 a liated societies and academies of science, serving 10 million individuals. Science has the largest paid circulation of any peer-reviewed general science journal in the world. The non-pro t AAAS (www.aaas.org) is open to all and ful lls its mission to “advance science and serve society” through initiatives in science policy, international programs, science education, public engagement, and more. For the latest research news, log onto EurekAlert!, www.eurekalert.org, the premier science-news Web site, a service of AAAS. See www.aaas.org. American Association for the Advancement of Science 1200 New York Avenue, NW • Washington, DC 20005 USA Tel: 202-326-6440 For more information about supporting AAAS, please e-mail developmento [email protected], or call 202-326-6636. On the Cover: As it takes flight in Kenya, this Eurasian roller (Coracias garrulous), with its magni cent blue and teal-colored wings, o ers a reminder of the promise of discovery and innovation for improving human welfare. Alan I. Leshner, AAAS CEO emeritus, captured this photograph in early 2015. Table of Contents Welcome Letter by Phillip A. Sharp and Rush D. Holt .....................
    [Show full text]