Vol. 3 Edition. 6 May - June 2019 HkS"kt lans”k landl lans”k

Message from Editor’s Desk

Welcome to all the reader...... So here we have “Bhaishaj ”, our completely transformed CONTENTS bimonthly institutional newsletter. The name of the newsletter may seem difficult but it just means Messages from the Pharmacy branch. This magazine gives deep information about the institutional activities,  Message from Editor’s Desk academic progress, achievements of students and contribution of  Columbia Institute of Pharmacy teachers and other crucial informations related to Pharmacy field.  Messages from Management’s Desk I am happy to introduce volume III of 6th edition of institutional  Message from Principal’s Desk newsletter. I do hope that the newsletter encourages many more  New Faculties Joined  Campus Interview including students to use it as a platform to express their creativity.  New Branch affiliation Please feel free to offer any suggestion for improvement.  Achievements Sincerly  HR and Technical Meet Dr. Ravindra Pandey  Research Activity  NSS Cell Activity  International yoga Day Celebration  Less Known Facts about Traditional Food Editorial Board  Causerie  Students’ Thought  GPAT Quiz  New Drug Approval 1. Dr. Ravindra Pandey  Plants with Health Benifits Professor, CIP, Raipur  Upcoming Events 2. Disha Kesharwani  Inspiring Quotes Assistant Professor, CIP, Raipur  Picture Gallary 3. Aparajita Guha B. pharm 6th Sem

Columbia Institute of Pharmacy, Raipur

Columbia Institute of Pharmacy

It’s a great pleasure to introduce Columbia Institute of Pharmacy, which is Synonymous to ultimate in Pharmacy education in the state of . Columbia Institute of Pharmacy, Raipur is run and managed by Jan Pragati Education Society (JPES), established in the year 2003.Innovation excellence & quality are the driving forces on the vision of Columbia Institute of Pharmacy which has a rich proud heritage of academic excellence. The campus is lavishly spread over acres of lush green land and situated 14 km away from the hustle bustle of the city and just 4 km away from Chhattisgarh state assembly setting unabated efforts ton add value in Pharma, Engineering and Management education.

Columbia Institute of Pharmacy, Raipur

From the Management’s Desk......

Let me welcome you to our fold! As we welcome you, the budding pharmacists, future leaders and productive citizens of the world, I would like to stress on our mission statement of grooming young minds and hearts as the pillar of advancement of a nation and hope of the future.

Our institution is formed by a team of dedicated and highly qualified faculties and service-oriented individuals with the aim to promote education in all aspects in order to achieve and fulfill the mission statement that we believe in. As an established and highly esteemed institution, we maintain an utmost academic standard, incorporated with the conduct of discipline, thereby achieving remarkable and excellent percentage of results. We firmly believe that education is the key to a nation's progress with this; we will take it as our bounded duty to provide the best academic training a student can possibly get.

In whatever career a student may choose to take, hard work and discipline are the sure roads towards success. And as your educational institution, we will support you in achieving those golden ambitions and also ensure that your stay in the college is meaningful and fruitful as well.

I take this opportunity to congratulate the editorial board for bringing out this magazine as per schedule, which in itself is an achievement considering the effort and time required.

We wish you all the best!

Sincerely yours, Sincerely yours, Mr. Kishore Jadwani Mr. Harjeet Singh Hura Chairman, Secretary, Janpragati Education Society Janpragati Education Society

Columbia Institute of Pharmacy, Raipur

Principal’s Message......

It gives me immense pleasure to present to you completely transformed edition of our newsletter, with its name “Bhaisaj Sandesh” as I feel that this would expand the horizons of knowledge and creativity of the students. The newsletter aims at providing information and highlighting various activities and improvements of the institute.

I wish the editorial board, faculty members and students all the best in this new venture, and also congratulate them for their dedicated efforts put in to bring out the new editions of newsletter.

I welcome the new batch….

Dear students, you are about to cross a bridge in your life because college education is a turning point itself. It is in your hands to make sure that bridge leads you towards success. The hard work of today is the triumph of the future. The time and effort you spend today are the deciding factors of your later years. As the Principal of this institution, I anticipate the full participation and cooperation of the students and parents to make it possible for us to transform those dreams to reality. And if there is any assistance that you might need, may it be personal or professional, I shall always be willing to hear from you.

Best Wishes...... Sincerely, Prof. Amit Roy, Principal, Columbia Institute of Pharmacy

Columbia Institute of Pharmacy, Raipur

Newly Joined Faculties

Dr. Santosh Prajapati, Ph.D., Post Doc M. Pharm (Medicinal Chemistry) Thrust Area –

 Design and synthesis of novel bioactive compounds  Drug discovery  Development of novel synthetic methodologies in pharmaceutical sciences  Green chemistry, Computational and analytical Chemistry

Dr. Beena Gidwani, Ph.D., Post Doc

M. Pharm(Quality Assurance) Thrust Area –  Nanotechnology,  Cyclodextrin complexation, Solubility enhamcement of BCS II drugs  Validation,  Drug delivery system for herbal and synthetic drugs,  Cancer.

Dr. Rudra Pratap Singh, M. Pharm, Ph. D M. Pharm (Pharmaceutics) Thrust Area -  Novel drug delivery system  nanotechnology.

Campus Interview We are pleased to inform you that on 13th March2019 M/S Macleods Pharmaceuticals Ltd., Edrant Pharmaceuticals and Themis Medicare Ltd. leading multinational Pharmaceutical Companies conducted Campus Interview in Columbia Institute of Pharmacy. Our 12 students are got selected in Quality control department. We congratulate our students for their success. The students are-

S. Name of the students Company Class No. 1. Mr. Arvind Sahu Macleods Pharmaceuticals Ltd. M. Pharm IV Semester 2. Mr. Devwrat Sahu Macleods Pharmaceuticals Ltd. B. Pharm VIII Semester 3. Mr. Nitin kumar Sahu Macleods Pharmaceuticals Ltd. B. Pharm VIII Semester 4. Mr. Ashish Tamrakar Macleods Pharmaceuticals Ltd. B. Pharm VIII Semester 5. Mr. Naresh Chandra Macleods Pharmaceuticals Ltd. B. Pharm VIII Semester 6. Mr. Bhupinder Sonwani Macleods Pharmaceuticals Ltd. B. Pharm VIII Semester 7. Mr. Daymond Sahu Macleods Pharmaceuticals Ltd. B. Pharm VIII Semester 8. Mr. Ankit Chourasia Macleods Pharmaceuticals Ltd. B. Pharm VIII Semester 9. Mr. Yogesh Raj Macleods Pharmaceuticals Ltd. B. Pharm VIII Semester 10. Ms. Deeksha Bharadwaj Macleods Pharmaceuticals Ltd. B. Pharm VIII Semester 11. Mr. Saurabh Mule Edrant Pharmaceuticals B. Pharm VIII Semester 12. Mr. Suman Lal Nishad Themis Medicare Ltd. B. Pharm VIII Semester Columbia Institute of Pharmacy, Raipur

Infotmation about Cryoviva Campus

th Cryoviva India, the only Indian multinational cord blood bank, also visited CIP on 27 May for campus interview. Our students Laxmikant Yadav, Nokita Sharma, and Mayank Thakur got selected for different branches of Cryoviva. The company is focused on providing high-quality umbilical cord blood stem cell processing, and storage for both private and public donation purposes. Based at

Gurugram with networks in all the towns of India provides a high end processing and storage technology which are approved by International authorities.

New Branch Affiliation for M. Pharm

We are happy to share to all the readers that Columbia Institute of Pharmacy got affiliation for a new branch of “Phytomedicine” for M. Pharmacy. 15 Seats are available under this branch.

Columbia Institute of Pharmacy, Raipur

Achievements

Faculties of Columbia Institute of Pharmacy, Dr. Pushpa Prasad and Dr. S P Rao participated in PCI Sponsored Continuing Education Program (CEP) “Effective Teaching-Learning in Pharmacy

Education” organized by Rungta College of Pharmaceutical Sciences and Research, Bhilai from 27-29 March 2019.

Guest Lectures

A guest lecture was delivered by Prof. Amit Roy, Principal, CIP, on 29th March, at PCI Sponsored Continuing Education Program (CEP) “Effective Teaching-Learning in Pharmacy Education” organized by Rungta College of Pharmaceutical Sciences and Research , Bhilai.

The title of the lecture was “Strategies for Effective Teaching”

Prof HR and Technical Meet

Columbia Institute of Pharmacy organized HR and Technical meet 2019 especially for final year students on 18th May. The program was sponsored by Jan Pragati Education Society. The program is intended to acquaint the participants with the knowledge that industries want from a

fresher candidate. It would help the participants to face the personal interviews and technical rounds and also the knowledge gained shall help during the internship in industry. The invited guest speakers were Mr.Niilesh V Thakkar, Mr.Devendra Kumar Dewangan, Mr. Mukesh Singh Chhawari and Dr.Ram Sahu from various industries and organizations. Students from different colleges also actively participated in the program and also in mock interview taken by the guests.

Columbia Institute of Pharmacy, Raipur

Research Activity 35 students from Chemistry department of Sarguja University, Ambikapur came for doing their research work under MSc Dissertation. They worked in Columbia Institute of Pharmacy from 29/04/19- 08/05/19. They performed different analytical and phytochemical tests under the supervision of Dr. Pushpa Prasad.

NSS Cell Activity – Unnat Bharat Abhiyaan

Columbia Institute of Pharmacy’s NSS Unit participated in Unnat Bharat Abhiyaan under the supervision of NSS head Mr. Sagar Sahu and Mr. Mithlesh Kumar Chandrakar in nearby villages Tekari, Mandhar, Bhurkoni, Chhapora and Baroda from 20 April 2019. It was followed

by a rally. Through this awareness rally, NSS member shared information regarding importance of voting for growth of nation with the villegers. The awareness campaign commenced arround 9:30 am. About 38 students actively participated in awareness campaign and rally.

Columbia Institute of Pharmacy, Raipur

International Yoga Day Celebration

Columbia Group of Institution celebrated International Yoga Day on 21st June 2019. On this occasion, students,

faculty members, management and other staff practiced yoga. The Yoga session was convened by Yoga Trainer, Mr. Namesh Kumar Sahu and two students Shakshi and Muskan, the gold medal winners at “2nd South Asian Yoga Champianship”.

Less Known facts about Traditional Food

‘Panta bhat’ Synonyms: Fermented , Baasi, Pakhala, Jiuniang, Poitabhat Recipe: It rice-based dish prepared by soaking rice, generally leftover, in water overnight. Traditionally served in the morning with salt, onion and chili. Panta bhat has more micronutrients than fresh rice. Nutritional Value

In a study conducted by agricultural biotechnology department of the Agricultural University it was concluded that cooked rice had an element that prevented the availability of minerals like iron, potassium, sodium and calcium in high quantities, and the breakdown of the nutritional inhibitor by the lactic acid bacteria increased the mineral content manifolds. Contents Panta Bhat Vs Cooked Rice Iron: 0.73 mg/gm 0.034mg/gm Calcium: 8.5 mg/gm 0.21 mg/gm Riboflavin High Low and vitamin B- 16 & B- 12 Many essential bacteria High Low *Fermented rice makes body light and increases work power. Remedial Value:  It is a preferred food for children with a fever.  It has the component to increase bone and muscle strength and age resistance immune system.  It cures gastroenteritis and maintains heat balance of body.  It reduces constipation and maintains body freshness, blood pressure and mood of human.  It also mitigates problems caused by allergies and keeps skin better.  It cures all types of ulcers and increases immunity system. Columbia Institute of Pharmacy, Raipur

Causerie Super Critical Fluid Extraction Technology The supercritical fluid extraction is a separation method in which separation of chemicals, flavours from the products such as coffee, tea, hops, herbs, and spices which are mixed with supercritical fluid to form a mobile phase. In this process, the mobile phase is subjected to pressures and temperatures near or above the critical point for the purpose of enhancing the mobile phase solvating power.

The process begins with CO2 in vapour form. The use of supercritical fluids, especially carbon dioxide, SFE is a simple, inexpensive, fast, effective and virtually solvent-free sample pre treatment technique. SFE is usually performed with pure or modified carbon dioxide, which facilitates off-line collection of extracts and on-line coupling with other analytical methods such as gas, liquid and supercritical fluid chromatography. In this review, we showed that a number of factors influence extraction yields, these being solubility of the solute in the fluid, diffusion through the matrix and collection process. Finally, SFE has been compared with conventional extraction methods in terms of selectivity, rapidity, cleanliness and possibility of manipulating the composition of the extract. The principle of supercritical fluid extraction is the optimization of the solubility of materials to be extracted (lipids, heavy metals,

natural products) in supercritical CO2 and the improvement of the fractionation with respect to a particular lipid species, natural products Supercritical fluid extraction facilitates the detachment of the extract from the supercritical fluid solvent by simple expansion. StudentGunjan Kalyani’ s Section Assistant Professor, CIP, Raipur

Students’ Thought

How to choose which goals to focus on?

1. Identify your cornerstone goals:- As a starting point, remind yourself of your biggest priority for the upcoming months and years. Simply stepping back, recalling what matters the most has a grounding influence whenever your schedule gets hectic and trivialities begin to take over 2. Think about the 'why':- Decide whether you're going after your goals or taking part in certain activities for the right reasons. Write down your goals, reflecting on why each one is important to you and its role in your life. 3. The three or more hobby rule:- Aspire to do something that makes you money (whether currently or in the future), something that makes you happy, something that keeps you fit and something that helps other people. Of course, the more thing overlap the better. 4. Journal and reflect with honesty:- Journaling in an excellent tool for making sense of our thoughts and understanding ourselves. More often than not, being honest with ourselves and writing things down paves the way for a realization and therefore change within our life as a whole. 5. Look to the future:- Always think bigger what will your life look like thus time nest year? What big event, changes or plans may impact your current routine? Plan accordingly and keep this mind when setting goals and choosing where to channel your efforts.

Sanjana Panjawani, B. Pharm, II Sem Columbia Institute of Pharmacy, Raipur

GPAT Quiz- 1 1. 2. 1. Particle size range measurement by conductivity method the is a) 0.5 to 500 μm b) 5 to 100 μm c) 50 to 100 μm d) 100 to 200 μm 3. 2. Reserpine on hydrolysis gives : a) Reserpic acid + Methyl alcohol + Trimethoxy cinnamic acid b) Reserpic acid + Acetic acid + Trimethoxy benzaldehyde c) Reserpic acid + Methyl alcohol + Trimethoxy benzoic acid d) Reserpic acid + Methyl alcohol + Trimethoxy cinnamaldehyde 3. Salbutamol sulphate IP is assayed by a) Direct titration with standard sodium hydroxide solution b) Direct titration with standard sodium hydrochloric acid c) A known amount of standard acid is added and excess is titrated with standard Alkali d) Dissolve in glacial acetic acid and titrated with standard perchloric acid using oracet blue. 4. The mantoux test uses : a) Old tuberculin b) Diptheria toxins c)Serum antigensb d) Polysaccharide antigens 5. Resolution of a spectrophotometer is: a) It’s a wavelength range b) Its ability to distinguish adjacent absorption bands c) It’s a capacity for its continuous use d) Its power to gather light according to source 6. Glandular hair growing having a unicellular or occasionally a short uniserate pedicel with a unicellular or bicellular terminal gland is characteristics of a) Senna leaves b) Belladonna leaves c) Datura stramonium leaves d) Digitalis Purpurea leaves 7. R.W. C. is used to identify the strength of an: a) Antibiotics b) Antipyretics c) Antiseptic d) Antiinflammatory 4. 8. The essential structural unit for the anthelmentics activity of mebendazole is a) Benzoyl group b) Benzimidazole c) Methyl carbamates d) Imidazole 9. The anticoagulant activity of heparin sodium injection IP is estimated using: a) Female rats b) male rats c) Rabbits d) Sheep 10. In the steroid nucleus, they are a) Six chiral center with nucleus i.e. 5,8,9,10,13, and 14 b) Seven chiral center with nucleus i.e. 3,8,9,10,11, 12 and 14 c) Six chiral center with nucleus i.e. 3,8,9,10,11, and 12 d) Six chiral center with nucleus i.e. 5,7,9,10,13, and 16

New Drug Approved in 2019 Polivy Company: Genentech Pharmaceuticals Approval Status: Approved June 2019

Specific Treatments: diffuse large B-cell lymphoma Therapeutic Areas: Hematology, Oncology Polivy is supplied as a solution for intravenous injection. Mechanism of Action Polivy (polatuzumab vedotin-piiq) is an anti-CD79b antibody-drug conjugate (ADC). The CD79b protein is expressed specifically in the majority of B-cells, an immune cell impacted in some types of non-Hodgkin’s lymphoma (NHL). Polivy binds to CD79b and destroys these B-cells through the delivery of an anti-cancer agent, which is thought to minimize the effects on normal cells.

Side Effects Low white blood cell count, low platelet levels, numbness, tingling or pain in the hands and feet, diarrhea fever decreased appetite, pneumonia.

Columbia Institute of Pharmacy, Raipur Plants with Health Benefits Amorphophallus paeoniifolius – Surana, Elephant Foot Yam

Scientific classification Kingdom: Plantae Clade: Angiosperms Clade: Monocots Order: Alismatales Family: Araceae Genus: Amorphophallus Species: A. paeoniifolius Names in different languages: Sans. - Arsaghna, Balukand; Hindi – Suran, Jamikand, Surankand, Suran Kand; English – Elephant foot yam, Elephant yam, Stanley s water - tub, Konjac; Bengali – Ol; Gujrati – Suran; Marathi – Suran; Kannada– Suvarnagadde; Malayalam– Chena.

Morphology: Plant height - 2-4 feet with weak stem, blooms annually around the beginning of the raining season. Leaves - 2-3 feet wide. Flower - bud emerged from the corm as a purple shoot and later blooms as a purple inflorescence, lasts only about 5 days Fruit - 3-4 inch in size, red colored and have 2-3 seeds. Tuber - grows in big size, about 1-2 feet in diameter, dark brown in color. Elephant Foot Yam is perhaps one of the ugliest flowers in the world and to accompany it, it has one of the worst scents that you can imagine. The plant only blooms when mature and even so it doesn't bloom every year. Area of Cultivation- Bihar, , Kerala, Karnataka, Andhra Pradesh, Maharashtra and Orissa.

Chemical composition: The corn contains an active diastatic enzyme amylase, betulinic acid, tricontane, lupeol, stigmasterol, beta – sitosterolanditspalmitateandglucose, galactose, rhamnose, calcium oxalate and xylose.

Nutritional value: Elephant foot yam tubers contain P (34 mg/100 g), calcium (50 mg/100 g), vitamin A (434 IU/100 g), crude protein (2.14%), fat (0.46%), calcium (32.1 mg/100 g) and crude fiber (1.68%)5. The tuber also contains anti-nutrient factors, such as oxalate and phytate. The level of oxalic acid in the elephant foot yam is 1.3%.

Uses: It is an Ayurvedic herb, mentioned for the treatment of piles, amenorrhea, indigestion, anorexia, joint pain and elephantiasis.  Paste of tuber with to treat the leg affected with elephantiasis and swelling of the joint menstrual complaints.  For the treatment of piles, intestinal worms, indigestion and hepatomegaly (Dose- 10 ml).  For the treatment of amenorrhea (Dose- 15-20 g).  Cold infusion of tuber to treat cough and asthma (Dose of 15-20ml).  The dried powder of the tuber mixed with buttermilk to treat hemorrhoids and piles (dose of 3-4g).  Tuber of elephant yam is covered with mud, dried under sunlight and later burnt. The ash obtained is consumed to treat cases of internal growth like tumors (Dose- 5- 6 g).

Ayurvedic medicines containing Surana: Surana vataka: It is used in treatment of piles, indigestion, mal absorption syndrome, cough, cold, bronchitis, asthma, spleen disorders, inflammatory conditions, hiccups, fistula, urinary tract related diseases. It also acts as aphrodisiac, rejuvenative. Surana avaleha: The medicine is in a leha form which is used in the treatment of hemorrhoids, fistula and digestive diseases. Kutlab tablet: Kutlab Tablet is a proprietary Ayurvedic medicine which reduces swelling of veins, checks bleeding piles, controls inflammation and overcomes constipation. Bahushala guda: It is a medicine in leha form, mainly used in the treatment of piles, fistula, ascites, anemia, liver diseases. Urshoset tablet: It is a proprietary Ayurvedic medicine, used in the treatment of piles and constipation.

Columbia Institute of Pharmacy, Raipur

Inspiring Quotes

 Step outside your comfort zone and experience something to which you are not accustomed.

 Failure is the OPPORTUNITY to begin again more intelligently.  Successful and unsuccessful people do not vary greatly in their abilities. They vary in their desires to reach their potential.

 Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time.  Excellence is a continue process, not an accident.

 Success is when your signature changes to AUTOGREAPH.

Upcoming Events......

 Orientation Program

 Independence Day Celebration

Columbia Institute of Pharmacy, Raipur Picture Gallery

Columbia Institute of Pharmacy, Raipur