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GOLDMAN-CECIL Desde Cualquier Dispositivo Electrónico 55,9 mm 26 a EDICIÓN Incluye Una nueva forma de adquirir conocimientos gracias al acceso al contenido GOLDMAN-CECIL desde cualquier dispositivo electrónico. a Los contenidos están íntegramente en inglés en inglés a Tratado de Características del contenido: 26 26 EDICIÓN BUSCABLE EDICIÓN Sistema fácil e intuitivo MEDICINA de navegación y búsqueda INTERNA PORTÁTIL Integración fluida y en tiempo real GOLDMAN-CECIL entre dispositivos, con acceso al contenido Lee Goldman, MD, y Andrew I. Schafer, MD con o sin conexión La obra que todo médico necesita para cuidar a los pacientes adultos. PERPETUO Para ser el mejor médico se necesita la mejor información. Durante más de no- Acceso permanente Tratado de venta años, lo que ahora se conoce como Goldman-Cecil. Tratado de medicina interna ha sido la fuente autorizada por antonomasia de la medicina interna y la atención a los pacientes adultos. Los capítulos son obra de los más reconocidos Información sobre el acceso, en el interior expertos, que, bajo la supervisión de los directores, ofrecen pautas definitivas y de la cubierta. objetivas sobre el diagnóstico y el tratamiento de miles de alteraciones, tanto fre- cuentes como inusuales, tomando siempre como base el conocimiento de la epi- La licencia de uso de la edición actual de la versión electrónica de este título MEDICINA demiología y la biopatología, así como la más reciente bibliografía médica. Pero (ebook) es individual e intransferible. Goldman-Cecil. Tratado de medicina interna no es solo un libro de texto, ya que, El acceso al ebook se limita a la primera de Tratado persona que activa el código de acceso a lo largo del tiempo de vigencia de cada edición original, las actualizaciones pe- facilitado en el interior de la cubierta, riódicas en línea incorporan la más reciente información tomada de una amplia y no puede transferirse a terceros INTERNA mediante reventa, préstamo ni ningún GOLDMAN-CECIL diversidad de revistas médicas (contenido en inglés). MEDICINA otro medio. Goldman-Cecil. Tratado de medicina interna incluye: INTERNA n Más de 400 capítulos refrendados por la acreditada autoría de los más signi- ficados representantes de la medicina moderna. VOLUMEN 1 n Una organización uniforme y práctica, que hace especial hincapié en estu- VOLUMEN 1 dios basados en la evidencia. CAPÍTULOS 1-193 n Miles de algoritmos, imágenes y tablas, que hacen más fácilmente accesible la información. GOLDMAN LEE GOLDMAN n La versión digital de la obra original incluida en la compra (contenido en in- glés) con acceso, a través de distintos dispositivos, al texto, las figuras y la SCHAFER bibliografía completa del libro, y donde el contenido es permanentemente ac- CROW | DAVIDSON ANDREW I. SCHAFER tualizado por Lee Goldman, MD. Además, incluye vídeos y audios cardíacos. DRAZEN | GRIGGS LANDRY | LEVINSON CROW | DAVIDSON | DRAZEN | GRIGGS | LANDRY RUSTGI | SCHELD | SPIEGEL LEVINSON | RUSTGI | SCHELD | SPIEGEL ISBN 978-84-9113-765-8 9788491137658 Goldman 9788491137658 Vol. I.indd 1 23/2/21 19:04 Goldman-Cecil Tratado de medicina interna Propiedad de Elsevier rohibida su reproducción y venta P C0165.indd i 18/02/21 3:44 PM Propiedad de Elsevier Prohibida su reproducción y venta C0165.indd ii 18/02/21 3:44 PM Goldman-Cecil Tratado de medicina interna 26.ª EDICIÓN Volumen 1 Directores LEE GOLDMAN, MD Harold and Margaret Hatch Professor Chief Executive, Columbia University Irving Medical Center Dean of the Faculties of Health Sciences and Medicine Columbia University New York, New York ANDREW I. SCHAFER, MD Professor of Medicine Director, Richard T. Silver Center for Myeloproliferative Neoplasms Weill Cornell Medical College New York, New York Propiedad de Elsevier Prohibida su reproducción y venta C0165.indd iii 18/02/21 3:44 PM Avda. Josep Tarradellas, 20-30, 1.°, 08029, Barcelona, España Goldman-Cecil Medicine, 26th edition Copyright © 2020 by Elsevier, Inc. All rights reserved. Previous editions copyrighted 2016, 2012, 2008, 2004, 2000, 1996, 1991, 1988, 1982, 1979, 1975, 1971, 1963, 1959, 1955, 1951, 1947, 1943, 1940, 1937, 1933, 1930, 1927 by Saunders, an imprint of Elsevier, Inc. Copyright renewed 1991 by Paul Beeson. Copyright renewed 1979 by Russell L. Cecil and Robert F. Loeb. Copyright renewed 1987, 1975, 1971, 1965, 1961, 1958, 1955 by Elsevier, Inc. Th is book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Chapter 104: Julian White retains copyright to his original fi gures/images appearing in the chapter. Th e following contributors are US government employees and their contributions are in public domain: David Atkins (chapter 12), John O’Shea (chapter 33), Leslie Biesecker (chapter 36), Amy Klion (chapter 161), Donna Krasnewich & Ellen Sidransky (chapter 197), Lynnett e Nieman (chapter 208, 214, 218), Richard Siegel & Daniel Kastner (chapter 245), Roland Sutt er (chapter 276), Paul Mead (chapter 296), Joseph Kovacs (chapter 321), Louis Kirchhoff (chapter 326), eodoreTh Nash (chapter 330), Neal Young (chapter 347) and Jeff rey Cohen (chapter 351). ISBN: 978-0-323-53266-2 Th is translation of Goldman-Cecil Medicine, 26th edition by Lee Goldman and Andrew I. Schafer was undertaken by Elsevier España, S.L.U. and is published by arrangement with Elsevier, Inc. Esta traducción de Goldman-Cecil Medicine, 26th edition, de Lee Goldman y Andrew I. Schafer, ha sido llevada a cabo por Elsevier España, S.L.U. y se publica con el permiso de Elsevier, Inc. Goldman-Cecil. Tratado de medicina interna, 26.ª edición, de Lee Goldman y Andrew I. Schafer © 2021 Elsevier España, S.L.U., 2016, 2013, 2009. ISBN (obra completa): 978-84-9113-765-8 ISBN (volumen 1): 978-84-9113-763-4 ISBN (volumen 2): 978-84-9113-764-1 eISBN: 978-84-9113-936-2 Todos los derechos reservados. Reserva de derechos de libros Cualquier forma de reproducción, distribución, comunicación pública o transformación de esta obra solo puede ser realizada con la autorización de sus titulares, salvo excepción prevista por la ley. Diríjase a CEDRO (Centro Español de Derechos Reprográfi cos) si necesita fotocopiar o escanear algún fragmento de esta obra ( www.conlicencia.com ; 91 702 19 70/93 272 04 45). Advertencia Esta traducción ha sido llevada a cabo por Elsevier España, S.L.U. bajo su única responsabilidad. Facultativos e investigadores deben siempre contrastar con su propia experiencia y conocimientos el uso de cualquier información, método, compuesto o experimento descritos aquí. Los rápidos avances en medicina requieren que los diagnósticos y las dosis de fármacos recomendadas sean siempre verifi cados personalmente por el facultativo. Con todo el alcance de la ley, ni Elsevier, ni los autores, los editores o los colaboradores asumen responsabilidad alguna por la traducción ni por los daños que pudieran ocasionarse a personas o propiedades por el uso de productos defectuosos o negligencia, o como consecuenciaPropiedad de la aplicación de métodos, de productos, Elsevier instrucciones o ideas contenidos en esta obra. Revisores científi cos: José M.ª Ladero Quesada, catedrático de MedicinaProhibida Interna, Facultad de Medicina, su Universidadreproducción Complutense de Madrid. Responsabley venta del Servicio de Aparato Digestivo, Hospital Clínico San Carlos, Madrid. Académico correspondiente de la Real Academia Nacional de Medicina (España). Luis Rodríguez Padial, jefe del Servicio de Cardiología, Complejo Hospitalario de Toledo. Alberto García Vadillo, jefe de la Sección de Reumatología, Hospital Universitario de la Princesa, Madrid. Profesor asociado de Reumatología, Facultad de Medicina, Universidad Autónoma de Madrid. Manuel L. Fernández Guerrero, especialista en Medicina Interna, y en Microbiología y Parasitología, profesor titular de Medicina, Facultad de Medicina, Universidad Autónoma de Madrid. Jefe del Servicio de Medicina Interna, Fundación Jiménez Díaz, Madrid. M.ª Jesús Fernández Aceñero, especialista en Anatomía Patológica, profesora titular de Anatomía Patológica, Facultad de Medicina, Universidad Complutense de Madrid. Jefa del Servicio de Anatomía Patológica, Hospital General Universitario Gregorio Marañón, Madrid. Juan Manuel Igea Aznar, especialista en Alergología e Inmunología, práctica privada. M.ª Victoria Torres Pardo, especialista en Neurología, práctica privada. Ricardo Gayá Moreno, especialista en Oft almología, facultativo, Departamento de Oft almología, Hospital Valle de los Pedroches, Pozoblanco (Córdoba). Ignacio Navascués Benlloch, especialista en Medicina Interna, miembro del Equipo Técnico del Diccionario de términos médicos de la Real Academia Nacional de Medicina (España). Enrique Artozqui Morrás, especialista en Endocrinología y Nutrición, y en Urología, facultativo, Servicio de Urología, Hospital Donostia, San Sebastián. Servicios editoriales: Gea Consultoría Editorial, S.L. Depósito legal: B. 3.271-2021 Impreso en España C0170.indd iv 18/02/21 3:51 PM ÍNDICE DE CAPÍTULOS 22 Secuelas clínicas frecuentes del envejecimiento 102 VOLUMEN 1 JEREMY D. WALSTON SECCIÓN I: ASPECTOS ÉTICOS Y SOCIALES EN MEDICINA 23 Incontinencia urinaria 105 1 Aproximación a la medicina, el paciente y la profesión NEIL M. RESNICK médica: la medicina como una profesión ilustrada y humana 2 24 Aspectos neuropsiquiátricos del envejecimiento 109 LEE GOLDMAN Y ANDREW I. SCHAFER SHARON K. INOUYE 2 Bioética en la práctica de la medicina 4 25 Delirium en pacientes ancianos 113 EZEKIEL J. EMANUEL SHARON K. INOUYE 3 Cuidados paliativos 10 ROBERT M. ARNOLD SECCIÓN V: FARMACOLOGÍA CLÍNICA 4 Disparidades en
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