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3Rd Joint Meeting of BSA and NCAB DEPARTMENT OF HEALTH AND HUMAN SERVICES PUBLIC HEALTH SERVICE NATIONAL INSTITUTES OF HEALTH NATIONAL CANCER INSTITUTE 3RD JOINT MEETING OF THE BOARD OF SCIENTIFIC ADVISORS AND THE NATIONAL CANCER ADVISORY BOARD Summary of Meeting June 23–24, 2014 Building 31C, Conference Room 10 National Institutes of Health Bethesda, Maryland 3rd Joint Meeting of the Board of Scientific Advisors and the National Cancer Advisory Board NATIONAL CANCER ADVISORY BOARD BETHESDA, MARYLAND Summary of Meeting June 23–24, 2014 The Board of Scientific Advisors (BSA) and the National Cancer Advisory Board (NCAB) convened for the 3rd Joint Meeting on 23–24 June 2014, in Conference Room 10, C Wing, Building 31, National Institutes of Health (NIH), Bethesda, MD. The meeting was open to the public on Monday, 23 June 2014, from 8:30 a.m. to 6:00 p.m., and Tuesday, 24 June 2014, from 8:30 a.m. to 10:45 a.m. and closed to the public on Tuesday, 24 June 2014, from 10:45 a.m. to 11:10 a.m. The BSA Chair, Todd R. Golub, Chief Scientific Officer, The Broad Institute of Harvard University and Massachusetts Institute of Technology, and the NCAB Chair, Tyler Jacks, Director, Koch Institute for Integrative Cancer Research, David H. Koch Professor of Biology, Massachusetts Institute of Technology, presided during the open session. Dr. Jacks presided during the closed session. BSA Members Dr. Cheryl L. Walker Dr. Todd R. Golub (Chair) Dr. Irving L. Weissman Dr. Kenneth C. Anderson (absent) Dr. Francis Ali-Osman NCAB Members Dr. Dafna Bar-Sagi Dr. Tyler E. Jacks (Chair) Dr. Ethan M. Basch Dr. Victoria L. Champion Dr. Sangeeta N. Bhatia Dr. David C. Christiani Dr. Andrea Califano Dr. Marcia R. Cruz-Correa Dr. Arul M. Chinnaiyan (absent) Dr. Kevin J. Cullen Dr. Curt I. Civin Dr. Judy E. Garber (absent) Dr. Graham A. Colditz Mr. William H. Goodwin, Jr. Dr. Chi V. Dang (absent) Dr. Waun Ki Hong (absent) Dr. Robert B. Diasio (absent) Dr. Elizabeth M. Jaffee (absent) Dr. Daniel C. DiMaio Dr. Beth Y. Karlan Dr. Jeffrey A. Drebin Ms. Mary Vaughan Lester (absent) Dr. Brian J. Druker Dr. H. Kim Lyerly Dr. Karen M. Emmons (absent) Dr. Olufunmilayo I. Olopade (absent) Dr. Betty R. Ferrell Dr. Jennifer A. Pietenpol Dr. Kathleen M. Foley Dr. Mack Roach, III Dr. Stanton L. Gerson (absent) Dr. Jonathan M. Samet (absent) Dr. Joe W. Gray Dr. Charles L. Sawyers Dr. Chanita Hughes-Halbert Dr. William R. Sellers Dr. Joshua LaBaer Dr. Theodore S. Lawrence Alternate Ex Officio NCAB Members Mr. Don Listwin (absent) Dr. Michael A. Babich, CPSC (absent) Dr. Maria E. Martinez Dr. Patricia Bray, OSHA/DOL Dr. Luis F. Parada Dr. Vince Cogliano, EPA (absent) Dr. Martine F. Roussel Dr. Michael Kelley, VA (absent) Dr. Kevin M. Shannon Dr. John Balbus, NIEHS (absent) Ms. Mary L. Smith (absent) Dr. Richard Pazdur, FDA (absent) Dr. Lincoln Stein Dr. Michael Stebbins, OSTP (absent) Dr. Bruce W. Stillman Dr. Marie Sweeney, NIOSH (absent) Dr. Louise C. Strong Dr. Lawrence Tabak, NIH (absent) Dr. Frank M. Torti Dr. Sharlene Weatherwax, DOE (absent) Dr. Gregory L. Verdine (absent) ii 3rd Joint Meeting of the Board of Scientific Advisors and the National Cancer Advisory Board Members, Scientific Program Leaders, National Cancer Institute, NIH Dr. Harold Varmus, Director, National Cancer Institute Dr. Jeff Abrams, Co-Director, Division of Cancer Treatment and Diagnosis Dr. Robert Croyle, Director, Division of Cancer Control and Population Sciences Dr. James Doroshow, Deputy Director for Clinical and Translational Research Dr. Daniela S. Gerhard, Director, Office of Cancer Genomics Dr. Paulette S. Gray, Director, Division of Extramural Activities Dr. Peter Greenwald, Associate Director for Prevention Dr. Ed Harlow, Special Assistant for Science Planning Dr. Lee Helman, Scientific Director for Clinical Research, Center for Cancer Research Dr Warren Kibbe, Director, NCI Center for Bioinformatics and Information Technology Dr. Barry Kramer, Director, Division of Cancer Prevention Dr. Douglas R. Lowy, Deputy Director, National Cancer Institute Dr. Alan Rabson, Deputy Director, National Cancer Institute Dr. Dinah Singer, Director, Division of Cancer Biology Dr. Sanya Springfield, Director, Center to Reduce Cancer Health Disparities Dr. Louis Staudt, Director, Center for Cancer Genomics Dr. Joseph Tomaszewski, Co-Director, Division of Cancer Treatment and Diagnosis Dr. Ted Trimble, Director, Center for Global Health Dr. Margaret A. Tucker, Acting Director, Division of Cancer Epidemiology and Genetics Mr. Michael Weingarten, Director, Small Business Innovation Research Dr. Linda Weiss, Director, Office of Cancer Centers Dr. Jonathan Wiest, Director, Center for Cancer Training Dr. Robert Wiltrout, Director, Center for Cancer Research Ms. Joy Wiszneauckas, Executive Secretary, Office of the Director Dr. Robert Yarchoan, Director, Office of HIV and AIDS Malignancy Liaison Representatives Ms. Carolyn Aldige, Cancer Research and Prevention Foundation Dr. Jeff Allen, National Cancer Institute, Director’s Consumer Liaison Group Ms. Paula Bowen, Kidney Cancer Association Mr. William Bro, Kidney Cancer Association Dr. Carlton Brown, Oncology Nursing Society Dr. Carol Brown, Society of Gynecologic Oncologists Ms. Pamela K. Brown, Intercultural Cancer Council Ms. Suanna Bruinooge, American Society of Clinical Oncology Mr. George Dahlman, Leukemia and Lymphoma Society Mr. Matthew Farber, Association of Community Cancer Centers Dr. Margaret Foti, American Association for Cancer Research Dr. Leo Giambarresi, American Urological Association Dr. Francis Giardiello, American Gastroenterological Association Ms. Christy M.P. Gilmour, American Academy of Orthopaedic Surgeons Ms. Ruth Hoffman, Candlelighters Childhood Cancer Foundation Dr. Gerald F. Joseph, Jr. American College of Obstetricians and Gynecologists Ms. Rebecca A. Kirch, American Cancer Society Dr. Steven Klein, National Science Foundation Dr. W. Marston Linehan, Society of Urologic Oncology iii 3rd Joint Meeting of the Board of Scientific Advisors and the National Cancer Advisory Board Mr. Richard Martin, American Society of Therapeutic Radiology and Oncology Ms. Margo Michaels, Education Network to Advance Cancer Clinical Trials Dr. Patricia Mullan, American Association for Cancer Education Ms. Christy Schmidt, American Cancer Society Ms. Susan Silver, National Coalition for Cancer Survivorship Ms. Barbara Duffy Stewart, Association of American Cancer Institutes Ms. Pamela Wilcox, American College of Radiology COL (Ret.) James E. Williams, Jr., Intercultural Cancer Council Lance Armstrong Foundation—no representative iv 3rd Joint Meeting of the Board of Scientific Advisors and the National Cancer Advisory Board TABLE OF CONTENTS MONDAY, 23 JUNE 2014 I. Call to Order and Opening Remarks—Drs. Todd R. Golub and Tyler Jacks................................. 1 II. Future Board Meeting Dates—Drs. Todd R. Golub and Tyler Jacks ............................................ 1 III. NCI Director’s Report—Dr. Harold E. Varmus ........................................................................... 1 Questions and Answers ......................................................................................................... 3 IV. Final Report: Cancer Centers Working Group—Dr. Kevin J. Cullen............................................ 4 Questions and Answers ......................................................................................................... 4 V. Recognition of Departing BSA and NCAB Members—Drs. Harold E. Varmus, Todd R. Golub, and Tyler Jacks ........................................................................................... 6 VI. Clinical Trials Reporting Policy—Dr. Jeff Abrams ...................................................................... 6 Questions and Answers ......................................................................................................... 7 VII. SPORE Program Working Group Report—Dr. Toby Hecht ......................................................... 8 Questions and Answers ......................................................................................................... 9 VIII. New RFP Concept—NCI Staff .................................................................................................. 11 Division of Cancer Treatment and Diagnosis A Prospective Randomized Trial of Carbon Ion Versus Conventional Radiation Therapy for Locally Advanced, Unresectable Pancreatic Cancer— Dr. Bhadrasain Vikram ................................................................................................. 11 IX. The Use of Aspirin for Prevention and Treatment of Cancers—Drs. Barry Kramer and Andrew T. Chan ........................................................................................................... 12 Questions and Answers ....................................................................................................... 13 X. RFA/Coop Agr. Concepts—Reissues—NCI Staff ..................................................................... 15 Division of Cancer Prevention The Early Detection Network (EDRN)—Drs. Barry Kramer and Larry Norton ................... 15 Division of Cancer Control and Population Sciences Breast Cancer and the Environment Research Program ....................................................... 18 Office of the Director Research Answers to NCI’S Provocative Questions—Dr. Edward E. Harlow ...................... 18 XI. Ongoing and New Business—Drs. Todd R. Golub and Tyler Jacks ........................................... 19 Ad Hoc Subcommittee on Global Cancer Research—Dr.
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