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Home , Actinin alpha 1, ANK1, Annexin A9, APOBEC2, Aspartylglucosaminidase, CALML3

Table: Significant list. From Banerjee AG et al, 2005. Molecular Therapeutics –05-0033

Relative Probeset ID Gene Name Description Fold expression 12.042 206785_s_at KLRC2 " killer cell lectin-like receptor subfamily C, member 3" 11.713 210163_at CXCL11 chemokine (C-X-C motif) ligand 11 3.972 205569_at LAMP3 lysosomal-associated membrane 3 3.732 202269_x_at GBP1 " guanylate binding protein 1, interferon-inducible, 67kDa" 3.317 202270_at GBP1 " guanylate binding protein 1, interferon-inducible, 67kDa" 2.828 205488_at GZMA " A (granzyme 1, cytotoxic T-lymphocyte- associated 3)" 2.789 205554_s_at DNASE1L3 I-like 3 2.732 220026_at CLCA4 " chloride channel, calcium activated, family member 4" 2.585 212190_at SERPINE2 " serine (or ) proteinase inhibitor, clade E (nexin, inhibitor type 1), member 2" 2.497 AFFX-HUMISGF3A STAT3 Stat3 protein /M97935_3_at 2.479 202953_at C1QB " complement component 1, q subcomponent, beta polypeptide" 2.395 201830_s_at NET1 neuroepithelial cell transforming gene 1 2.313 200798_x_at MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 2.219 219117_s_at FKBP11 " FK506 binding protein 11, 19 kDa" 2.114 204620_s_at CSPG2 chondroitin sulfate proteoglycan 2 (versican) 2.071 202620_s_at PLOD2 " procollagen-, 2- oxoglutarate 5-dioxygenase (lysine hydroxylase) 2" 2 208843_s_at GORASP2 " golgi reassembly stacking protein 2, 55kDa" 1.879 201669_s_at MARCKS myristoylated -rich protein kinase C 1.803 200782_at ANXA5 A5 11.713 205916_at S100A7 S100 calcium binding protein A7 (psoriasin 1) 10.928 211430_s_at IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker) 8.574 211906_s_at SERPINB4 " serine (or cysteine) proteinase inhibitor, clade B (), member 4" 8.515 1405_i_at CCL5 chemokine (C-C motif) ligand 5 8.225 209083_at CORO1A " coronin, binding protein, 1A" 6.233 34210_at CDW52 CDW52 antigen (CAMPATH-1 antigen) 6.021 211796_s_at TCRB "Homo sapiens T cell receptor beta chain BV20S1 BJ1-5 BC1 Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

mRNA, complete cds" 5.352 209126_x_at KRT6B 6B 5.278 206666_at GZMK " granzyme K (, granzyme 3; II)" 5.098 209800_at KRT16 (focal non- epidermolytic ) 4.691 213975_s_at LYZ lysozyme (renal amyloidosis) 4.347 216834_at RGS1 regulator of G-protein signalling 1 4.347 209924_at CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation- regulated) 4.199 203915_at CXCL9 chemokine (C-X-C motif) ligand 9 4.141 212588_at PTPRC " protein , receptor type, C" 4.112 219947_at CLECSF6 " C-type (calcium dependent, carbohydrate-recognition ) lectin, superfamily member 6" 4.056 218469_at CKTSF1B1 " cysteine knot superfamily 1, BMP antagonist 1" 3.972 204533_at CXCL10 chemokine (C-X-C motif) ligand 10 3.758 209720_s_at SERPINB3 " serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3" 3.706 209795_at CD69 " CD69 antigen (p60, early T- cell activation antigen)" 3.58 208146_s_at CPVL " carboxypeptidase, vitellogenic-like" 3.555 219386_s_at BLAME SLAM family member 8 3.531 217028_at CXCR4 chemokine (C-X-C motif) receptor 4 3.531 205900_at KRT1 (epidermolytic hyperkeratosis) 3.482 201645_at TNC tenascin C (hexabrachion) 3.387 206211_at SELE selectin E (endothelial adhesion molecule 1) 3.34 32128_at CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation- regulated) 3.272 218468_s_at CKTSF1B1 " cysteine knot superfamily 1, BMP antagonist 1" 3.182 209969_s_at STAT1 " signal transducer and activator of 1, 91kDa" 3.074 205419_at EBI2 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor) 3.074 205831_at CD2 " CD2 antigen (p50), sheep receptor" 3.074 205552_s_at OAS1 " 2',5'-oligoadenylate synthetase 1, 40/46kDa" 3.053 215536_at HLA-DQB2 " major histocompatibility complex, class II, DQ beta 2" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

3.031 220330_s_at SAMSN1 " SAM domain, SH3 domain and nuclear localisation signals, 1" 3.01 209773_s_at RRM2 ribonucleotide reductase M2 polypeptide 2.99 209823_x_at HLA-DQB1 " major histocompatibility complex, class II, DQ beta 1" 2.969 209606_at PSCDBP " pleckstrin homology, Sec7 and coiled-coil domains, binding protein" 2.949 209719_x_at SERPINB3 " serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3" 2.949 213680_at KRT6B 2.908 208450_at LGALS2 " lectin, galactoside-binding, soluble, 2 (galectin 2)" 2.908 204614_at SERPINB2 " serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2" 2.908 219505_at CECR1 " cat eye syndrome region, candidate 1" 2.888 210020_x_at CALML3 -like 3 2.77 221730_at COL5A2 " collagen, type V, alpha 2" 2.77 212998_x_at HLA-DQB2 " major histocompatibility complex, class II, DQ beta 2" 2.77 205595_at DSG3 desmoglein 3 (pemphigus vulgaris antigen) 2.732 211656_x_at HLA-DQB1 " major histocompatibility complex, class II, DQ beta 1" 2.713 206165_s_at CLCA2 " chloride channel, calcium activated, family member 2" 2.694 209218_at SQLE squalene epoxidase 2.694 208894_at HLA-DRA " major histocompatibility complex, class II, DR alpha" 2.676 213994_s_at SPON1 " spondin 1, (f-spondin) protein" 2.657 201852_x_at COL3A1 " collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)" 2.657 212236_x_at KRT17 2.657 201721_s_at LAPTM5 Lysosomal-associated multispanning - 5 2.639 203213_at CDC2 " cell division cycle 2, G1 to S and G2 to M" 2.603 205668_at LY75 lymphocyte antigen 75 2.585 201890_at RRM2 ribonucleotide reductase M2 polypeptide 2.585 204563_at SELL selectin L (lymphocyte adhesion molecule 1) 2.585 212488_at COL5A1 " collagen, type V, alpha 1" 2.567 204952_at C4.4A GPI-anchored - associated protein homolog 2.567 204751_x_at DSC2 desmocollin 2 2.567 207173_x_at CDH11 " cadherin 11, type 2, OB- cadherin (osteoblast)" 2.532 213539_at CD3D " CD3D antigen, delta Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

polypeptide (TiT3 complex)" 2.532 205269_at LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.532 211991_s_at HLA-DPA1 " major histocompatibility complex, class II, DP alpha 1" 2.514 209670_at TRA@ T cell receptor alpha 2.514 218986_s_at FLJ20035 FLJ20035 2.514 211748_x_at PTGDS prostaglandin D2 synthase 21kDa (brain) 2.497 200887_s_at STAT1 " signal transducer and activator of transcription 1, 91kDa" 2.497 212671_s_at HLA-DQA1 " major histocompatibility complex, class II, DQ alpha 1" 2.497 211654_x_at HLA-DQB1 " major histocompatibility complex, class II, DQ beta 1" 2.479 204655_at CCL5 chemokine (C-C motif) ligand 5 2.462 205157_s_at KRT17 keratin 17 2.462 202718_at IGFBP2 " insulin-like growth factor binding protein 2, 36kDa" 2.462 219995_s_at FLJ13841 FLJ13841 2.445 206164_at CLCA2 " chloride channel, calcium activated, family member 2" 2.428 201417_at SOX4 SRY (sex determining region Y)-box 4 2.428 202663_at WASPIP Wiskott-Aldrich syndrome protein interacting protein 2.412 212489_at COL5A1 " collagen, type V, alpha 1" 2.412 205483_s_at G1P2 " interferon, alpha-inducible protein (clone IFI-15K)" 2.395 203417_at MFAP2 microfibrillar-associated protein 2 2.378 213506_at F2RL1 factor II () receptor-like 1 2.378 201739_at SGK serum/glucocorticoid regulated kinase 2.362 204469_at PTPRZ1 " protein tyrosine phosphatase, receptor-type, Z polypeptide 1" 2.362 204774_at EVI2A ecotropic viral integration site 2A 2.362 61734_at RCN3 " reticulocalbin 3, EF-hand calcium binding domain" 2.346 213537_at HLA-DPA1 " major histocompatibility complex, class II, DP alpha 1" 2.346 213193_x_at TRB@ T cell receptor beta locus 2.329 213293_s_at TRIM22 tripartite motif-containing 22 2.313 221059_s_at CHST6 carbohydrate (N- acetylglucosamine 6-O) sulfotransferase 6 2.313 204472_at GEM GTP binding protein overexpressed in 2.313 208651_x_at CD24 CD24 antigen (small cell lung carcinoma cluster 4 antigen) 2.297 209436_at SPON1 " spondin 1, (f-spondin) extracellular matrix protein" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

2.297 213603_s_at RAC2 " ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)" 2.297 205081_at CRIP1 cysteine-rich protein 1 (intestinal) 2.282 202086_at MX1 " myxovirus (influenza virus) resistance 1, interferon- inducible protein p78 (mouse)" 2.282 209040_s_at PSMB8 " proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7)" 2.282 204962_s_at CENPA " centromere protein A, 17kDa" 2.266 214512_s_at PC4 (RNA pol activated RNA polymerase II II 4) transcription cofactor 4 2.266 204279_at PSMB9 " proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2)" 2.25 219918_s_at ASPM " asp (abnormal spindle)-like, microcephaly associated (Drosophila)" 2.25 212587_s_at PTPRC " protein tyrosine phosphatase, receptor type, C" 2.25 203325_s_at COL5A1 " collagen, type V, alpha 1" 2.235 209267_s_at BIGM103 " solute carrier family 39 (zinc transporter), member 8" 2.219 203502_at BPGM " 2,3-bisphosphoglycerate mutase" 2.219 202411_at IFI27 " interferon, alpha-inducible protein 27" 2.219 202546_at VAMP8 vesicle-associated membrane protein 8 (endobrevin) 2.204 208051_s_at PAIP1 polyadenylate binding protein- interacting protein 1 2.204 201850_at CAPG " capping protein (actin filament), -like" 2.204 203764_at DLG7 " discs, large homolog 7 (Drosophila)" 2.204 220038_at SGKL serum/glucocorticoid regulated kinase-like 2.204 40665_at FMO3 flavin containing 3 2.189 215193_x_at HLA-DRB1 " major histocompatibility complex, class II, DR beta 1" 2.189 206276_at E48 "lymphocyte antigen 6 complex, locus D" 2.173 210260_s_at GG2-1 TNF-induced protein 2.173 205191_at RP2 retinitis pigmentosa 2 (X- linked recessive) 2.173 203936_s_at MMP9 " matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)" 2.173 203917_at CXADR coxsackie virus and adenovirus receptor Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

2.173 209674_at CRY1 cryptochrome 1 (photolyase- like) 2.158 212815_at RNAH RNA helicase family 2.158 201137_s_at HLA-DPB1 " major histocompatibility complex, class II, DP beta 1" 2.144 204858_s_at ECGF1 endothelial cell growth factor 1 (platelet-derived) 2.144 202207_at ARL7 ADP-ribosylation factor-like 7 2.144 218888_s_at NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.144 201069_at MMP2 " matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)" 2.144 219787_s_at ECT2 epithelial cell transforming sequence 2 oncogene 2.129 203397_s_at GALNT3 UDP-N-acetyl-alpha-D- galactosamine:polypeptide N- acetylgalactosaminyltransferase 3 (GalNAc-T3) 2.129 201859_at PRG1 " proteoglycan 1, secretory granule" 2.129 203148_s_at TRIM14 tripartite motif-containing 14 2.129 204286_s_at PMAIP1 phorbol-12-myristate-13- acetate-induced protein 1 2.129 216250_s_at LPXN leupaxin 2.129 216237_s_at MCM5 " MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)" 2.129 221854_at PKP1 1 (ectodermal dysplasia/) 2.129 204780_s_at TNFRSF6 " tumor necrosis factor receptor superfamily, member 6" 2.114 209596_at DKFZP564I1922 adlican 2.099 44790_s_at C13ORF18 chromosome 13 open reading frame 18 2.099 209025_s_at NSAP1 NS1-associated protein 1 2.099 218875_s_at FBXO5 F-box only protein 5 2.099 204197_s_at RUNX3 runt-related transcription factor 3 2.085 219412_at RAB38 " RAB38, member RAS oncogene family" 2.085 209803_s_at PHLDA2 " pleckstrin homology-like domain, family A, member 2" 2.085 213238_at ATP10D " ATPase, Class V, type 10D" 2.085 204162_at HEC "highly expressed in cancer, rich in heptad repeats" 2.085 211075_s_at CD47 " CD47 antigen (Rh-related antigen, integrin-associated signal transducer)" 2.071 202446_s_at PLSCR1 1 2.056 201286_at SDC1 syndecan 1 2.056 202854_at HPRT1 hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

2.056 205666_at FMO1 flavin containing monooxygenase 1 2.056 212330_at TFDP1 transcription factor Dp-1 (TRANSCRIPTION FACTOR Dp1) 2.042 202503_s_at KIAA0101 KIAA0101 gene product 2.042 206033_s_at DSC3 desmocollin 3 2.042 209318_x_at PLAGL1 pleiomorphic adenoma gene-like 1 2.028 209156_s_at COL6A2 " collagen, type VI, alpha 2" 2.028 219209_at MDA5 differentiation associated protein-5 2.028 209166_s_at MAN2B1 " , alpha, class 2B, member 1" 2.028 206400_at LGALS7 " lectin, galactoside-binding, soluble, 7 (galectin 7)" 2.028 204198_s_at RUNX3 runt-related transcription factor 3 2.028 202489_s_at FXYD3 FXYD domain containing ion transport regulator 3 2.014 202345_s_at FABP5 fatty acid binding protein 5 (-associated) 2.014 213869_x_at THY1 Thy-1 cell surface antigen 2.014 201287_s_at SDC1 syndecan 1 2.014 201579_at FAT FAT tumor suppressor homolog 1 (Drosophila) 2.014 219352_at FLJ20637 FLJ20637 2.014 201889_at FAM3C " family with sequence similarity 3, member C" 2 201288_at ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 2 209873_s_at PKP3 plakophilin 3 2 221731_x_at CSPG2 chondroitin sulfate proteoglycan 2 (versican) 2 204122_at TYROBP TYRO protein tyrosine kinase binding protein 2 209748_at SPG4 spastic paraplegia 4 (autosomal dominant; spastin) 2 204994_at MX2 myxovirus (influenza virus) resistance 2 (mouse) 2 209619_at CD74 " CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)" 1.986 206561_s_at AKR1B10 " aldo-keto reductase family 1, member B10 (aldose reductase)" 1.986 200927_s_at RAB14 " RAB14, member RAS oncogene family" 1.986 209064_x_at PAIP1 polyadenylate binding protein- interacting protein 1 1.972 209312_x_at HLA-DRB3 " major histocompatibility complex, class II, DR beta 3" 1.972 202487_s_at H2AV histone H2A.F/Z variant 1.972 200713_s_at MAPRE1 " -associated protein, RP/EB family, member 1" 1.972 203868_s_at VCAM1 vascular cell adhesion Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

molecule 1 1.972 201920_at SLC20A1 " solute carrier family 20 (phosphate transporter), member 1" 1.959 204446_s_at ALOX5 arachidonate 5-lipoxygenase 1.959 202651_at KIAA0205 KIAA0205 gene product 1.959 212533_at WEE1 WEE1 homolog (S. pombe) 1.959 202469_s_at CPSF6 " cleavage and specific factor 6, 68kDa" 1.959 204057_at ICSBP1 interferon consensus sequence binding protein 1 1.959 203243_s_at LIM LIM protein (similar to rat protein kinase C-binding enigma) 1.959 206976_s_at HSPH1 heat shock 105kDa/110kDa protein 1 1.945 203964_at NMI N-myc (and STAT) interactor 1.945 208623_s_at VIL2 villin 2 () 1.945 200907_s_at KIAA0992 palladin 1.945 217762_s_at RAB31 " RAB31, member RAS oncogene family" 1.945 202214_s_at CUL4B 4B 1.945 204675_at SRD5A1 " steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4- dehydrogenase alpha 1)" 1.945 201487_at CTSC C 1.945 212446_s_at HYpothetical HYpothetical protein protein 1.945 202465_at PCOLCE procollagen C- enhancer 1.932 218578_at C1ORF28 open reading frame 28 1.932 202693_s_at STK17A serine/ kinase 17a (apoptosis-inducing) 1.932 221666_s_at ASC apoptosis-associated speck-like protein containing a CARD 1.932 201762_s_at PSME2 " proteasome (prosome, macropain) activator subunit 2 (PA28 beta)" 1.932 209259_s_at CSPG6 chondroitin sulfate proteoglycan 6 (bamacan) 1.932 215076_s_at COL3A1 " collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)" 1.932 218351_at FLJ20502 FLJ20502 1.932 214599_at IVL involucrin 1.932 201862_s_at LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 1.932 201894_s_at DCN decorin 1.919 217478_s_at HLA-DMA " major histocompatibility complex, class II, DM alpha" 1.919 202504_at TRIM29 tripartite motif-containing 29 1.919 211990_at HLA-DPA1 " major histocompatibility complex, class II, DP alpha 1" 1.919 201508_at IGFBP4 insulin-like growth factor binding protein 4 Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.919 221805_at NEFL " , light polypeptide 68kDa" 1.919 202932_at YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 1.905 200640_at YWHAZ " tyrosine 3- monooxygenase/ 5- monooxygenase activation protein, zeta polypeptide" 1.905 209082_s_at COL18A1 " collagen, type XVIII, alpha 1" 1.905 210138_at RGS20 regulator of G-protein signalling 20 1.905 203560_at GGH " gamma-glutamyl (conjugase, folylpolygammaglutamyl hydrolase)" 1.905 200626_s_at MATR3 matrin 3 1.905 218904_s_at FLJ10110 FLJ10110 1.905 218738_s_at RNF138 ring finger protein 138 1.892 203485_at RTN1 reticulon 1 1.892 200638_s_at YWHAZ " tyrosine 3- monooxygenase/tryptophan 5- monooxygenase activation protein, zeta polypeptide" 1.892 208998_at UCP2 " uncoupling protein 2 (mitochondrial, proton carrier)" 1.879 219403_s_at HPSE heparanase 1.879 208370_s_at DSCR1 Down syndrome critical region gene 1 1.879 203405_at DSCR2 Down syndrome critical region gene 2 1.879 200970_s_at SERP1 stress-associated endoplasmic reticulum protein 1 1.879 205548_s_at BTG3 " BTG family, member 3" 1.879 201649_at UBE2L6 -conjugating E2L 6 1.879 203854_at IF I factor (complement) 1.879 202911_at MSH6 mutS homolog 6 (E. coli) 1.879 206978_at CCR2 chemokine (C-C motif) receptor 2 1.879 202720_at TES testis derived transcript (3 LIM domains) 1.866 209728_at HLA-DRB4 " major histocompatibility complex, class II, DR beta 4" 1.866 208296_x_at GG2-1 TNF-induced protein 1.866 202391_at BASP1 " brain abundant, membrane attached signal protein 1" 1.866 217528_at CLCA2 " chloride channel, calcium activated, family member 2" 1.866 219288_at HT021 HT021 1.866 210715_s_at SPINT2 " serine protease inhibitor, Kunitz type, 2" 1.866 212612_at RCOR REST corepressor 1.853 204670_x_at HLA-DRB4 " major histocompatibility complex, class II, DR beta 4" 1.853 219936_s_at GPR87 G protein-coupled receptor 87 Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.853 218247_s_at LOC51320 LOC51320 1.853 200969_at SERP1 stress-associated endoplasmic reticulum protein 1 1.853 201689_s_at TPD52 tumor protein D52 1.853 213532_at LOC285148 LOC285148 1.853 202539_s_at HMGCR 3-hydroxy-3-methylglutaryl- Coenzyme A reductase 1.853 203477_at COL15A1 " collagen, type XV, alpha 1" 1.84 209473_at ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 1.828 213134_x_at BTG3 " BTG family, member 3" 1.828 206166_s_at CLCA2 " chloride channel, calcium activated, family member 2" 1.828 208839_s_at TIP120A TBP-interacting protein 1.828 218108_at C14ORF130 open reading frame 130 1.828 201563_at SORD sorbitol dehydrogenase 1.828 214470_at KLRB1 " killer cell lectin-like receptor subfamily B, member 1" 1.815 212893_at DKFZP564I052 DKFZP564I052 protein 1.815 203102_s_at MGAT2 " mannosyl (alpha-1,6-)- beta-1,2-N- acetylglucosaminyltransferase" 1.815 200698_at KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 1.815 222154_s_at DKFZP564A2416 DKFZP564A2416 protein 1.815 200833_s_at RAP1B " RAP1B, member of RAS oncogene family" 1.815 201653_at CNIH cornichon homolog (Drosophila) 1.815 201362_at IVNS1ABP influenza virus NS1A binding protein 1.815 212314_at KIAA0746 KIAA0746 protein 1.815 204527_at MYO5A " VA (heavy polypeptide 12, myoxin)" 1.815 200996_at ACTR3 ARP3 actin-related protein 3 homolog (yeast) 1.803 209576_at GNAI1 " guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1" 1.803 202075_s_at PLTP phospholipid transfer protein 1.803 204634_at NEK4 NIMA (never in gene a)-related kinase 4 1.803 218186_at RAB25 " RAB25, member RAS oncogene family" 1.803 202733_at P4HA2 " procollagen-, 2- oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II" 1.803 214848_at YWHAZ " tyrosine 3- monooxygenase/tryptophan 5- monooxygenase activation protein, zeta polypeptide" 1.79 217834_s_at NSAP1 NS1-associated protein 1 1.79 209081_s_at COL18A1 " collagen, type XVIII, alpha 1" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.79 222231_s_at PRO1855 PRO1855 1.79 217871_s_at MIF macrophage migration inhibitory factor (-inhibiting factor) 1.79 201131_s_at CDH1 " cadherin 1, type 1, E- cadherin (epithelial)" 1.778 220731_s_at FLJ10420 FLJ10420 1.778 200891_s_at SSR1 " signal sequence receptor, alpha (translocon-associated protein alpha)" 1.778 212168_at RBM12 RNA binding motif protein 12 1.778 211787_s_at EIF4A1 " eukaryotic translation initiation factor 4A, isoform 1" 1.778 210793_s_at NUP98 nucleoporin 98kDa 1.778 222258_s_at SH3BP4 SH3-domain binding protein 4 1.778 201664_at SMC4L1 SMC4 structural maintenance of 4-like 1 (yeast) 1.765 221253_s_at TXNDC5 thioredoxin domain containing 5 1.765 201690_s_at TPD52 tumor protein D52 1.765 220147_s_at TERA TERA protein 1.765 218360_at RAB22A " RAB22A, member RAS oncogene family" 1.765 212709_at NUP160 nucleoporin 160kDa 1.753 213102_at ACTR3 ARP3 actin-related protein 3 homolog (yeast) 1.753 205542_at STEAP six transmembrane epithelial antigen of the prostate 1.753 201667_at GJA1 " gap junction protein, alpha 1, 43kDa (connexin 43)" 1.753 201530_x_at EIF4A1 " eukaryotic translation initiation factor 4A, isoform 1" 1.753 221539_at EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.753 218002_s_at CXCL14 chemokine (C-X-C motif) ligand 14 1.753 203856_at VRK1 vaccinia related kinase 1 1.741 201302_at ANXA4 annexin A4 1.741 209186_at ATP2A2 " ATPase, Ca++ transporting, cardiac muscle, slow twitch 2" 1.729 214658_at CGI-109 CGI-109 protein 1.729 207668_x_at P5 protein disulfide - related protein 1.729 213618_at CENTD1 " centaurin, delta 1" 1.729 202712_s_at CKMT1 " kinase, mitochondrial 1 (ubiquitous)" 1.729 215884_s_at UBQLN2 ubiquilin 2 1.729 200777_s_at BZW1 basic leucine zipper and W2 domains 1 1.729 218109_s_at FLJ14153 FLJ14153 1.729 219496_at FLJ21870 FLJ21870 1.729 205713_s_at COMP " cartilage oligomeric matrix protein (pseudoachondroplasia, Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

epiphyseal dysplasia 1, multiple)" 1.717 204120_s_at ADK adenosine kinase 1.717 218499_at MST4 Mst3 and SOK1-related kinase 1.717 212250_at LYRIC LYRIC/3D3 1.717 203211_s_at MTMR2 myotubularin related protein 2 1.717 202346_at HIP2 huntingtin interacting protein 2 1.717 212812_at HYpothetical HYpothetical protein protein 1.717 203743_s_at TDG thymine-DNA glycosylase 1.717 201745_at PTK9 PTK9 protein tyrosine kinase 9 1.717 212442_s_at HYpothetical HYpothetical protein protein 1.717 201923_at PRDX4 peroxiredoxin 4 1.717 217970_s_at KIAA1194 KIAA1194 1.717 200975_at PPT1 " palmitoyl-protein 1 (ceroid- lipofuscinosis, neuronal 1, infantile)" 1.705 219330_at MGC5338 MGC5338 1.705 221840_at PTPRE " protein tyrosine phosphatase, receptor type, E" 1.705 201074_at SMARCC1 " SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1" 1.705 59644_at BMP2K BMP2 inducible kinase 1.705 208736_at ARPC3 " actin related protein 2/3 complex, subunit 3, 21kDa" 1.705 202088_at SLC39A6 " solute carrier family 39 (zinc transporter), member 6" 1.705 205135_s_at NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 1.705 202741_at PRKACB " protein kinase, cAMP- dependent, catalytic, beta" 1.693 220161_s_at EPB41L4B erythrocyte membrane protein band 4.1 like 4B 1.682 209569_x_at D4S234E DNA segment on (unique) 234 expressed sequence 1.682 218559_s_at MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) 1.682 201250_s_at SLC2A1 " solute carrier family 2 (facilitated glucose transporter), member 1" 1.682 209146_at SC4MOL sterol-C4-methyl -like 1.682 212766_s_at FLJ12671 FLJ12671 1.682 208829_at TAPBP TAP binding protein (tapasin) 1.67 211936_at HSPA5 " heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)" 1.67 202097_at NUP153 nucleoporin 153kDa 1.67 219528_s_at BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 1.659 204319_s_at RGS10 regulator of G-protein Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

signalling 10 1.659 203403_s_at RNF6 ring finger protein (C3H2C3 type) 6 1.659 219666_at MS4A6A " membrane-spanning 4-domains, subfamily A, member 6A" 1.659 202370_s_at CBFB " core-binding factor, beta subunit" 1.659 204364_s_at FLJ13110 FLJ13110 1.659 201438_at COL6A3 " collagen, type VI, alpha 3" 1.659 204616_at UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 1.647 213154_s_at BICD2 coiled-coil protein BICD2 1.647 212917_x_at RECQL RecQ protein-like (DNA helicase Q1-like) 1.647 204464_s_at EDNRA type A 1.647 215380_s_at C7ORF24 chromosome 7 open reading frame 24 1.636 200921_s_at BTG1 " B-cell translocation gene 1, anti-proliferative" 1.636 218170_at CGI-111 CGI-111 protein 1.636 218465_at FLJ10525 FLJ10525 1.636 221750_at HMGCS1 3-hydroxy-3-methylglutaryl- Coenzyme A synthase 1 (soluble) 1.625 201133_s_at PJA2 " praja 2, RING-H2 motif containing" 1.625 212637_s_at WWP1 WW domain-containing protein 1 1.625 200625_s_at CAP1 " CAP, adenylate cyclase- associated protein 1 (yeast)" 1.625 204141_at TUBB " , beta polypeptide" 1.613 208731_at RAB2 " RAB2, member RAS oncogene family" 1.613 201152_s_at MBNL1 muscleblind-like (Drosophila) 1.613 202096_s_at BZRP benzodiazapine receptor (peripheral) 1.613 200654_at P4HB " procollagen-proline, 2- oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55)" 1.613 203041_s_at LAMP2 lysosomal-associated membrane protein 2 1.613 201207_at TNFAIP1 " tumor necrosis factor, alpha- induced protein 1 (endothelial)" 1.613 202633_at TOPBP1 topoisomerase (DNA) II binding protein 1.602 218092_s_at HRB HIV-1 Rev binding protein 1.602 208754_s_at NAP1L1 nucleosome assembly protein 1- like 1 1.602 221830_at RAP2A " RAP2A, member of RAS oncogene family" 1.602 205401_at AGPS alkylglycerone phosphate synthase 1.602 210213_s_at ITGB4BP integrin beta 4 binding protein Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.602 201196_s_at AMD1 adenosylmethionine decarboxylase 1 1.602 213101_s_at ACTR3 ARP3 actin-related protein 3 homolog (yeast) 1.602 213135_at TIAM1 T-cell lymphoma invasion and metastasis 1 1.591 212353_at SULF1 1 1.591 202786_at STK39 " serine threonine kinase 39 (STE20/SPS1 homolog, yeast)" 1.591 207121_s_at MAPK6 mitogen-activated protein kinase 6 1.58 201659_s_at ARL1 ADP-ribosylation factor-like 1 1.58 208801_at SRP72 signal recognition particle 72kDa 1.569 217922_at MAN1A2 " mannosidase, alpha, class 1A, member 2" 1.569 201938_at CDK2AP1 CDK2-associated protein 1 1.569 218684_at LRRC5 leucine-rich repeat-containing 5 1.569 201940_at CPD carboxypeptidase D 1.558 212667_at SPARC " secreted protein, acidic, cysteine-rich ()" 1.558 218059_at LOC51123 HSPC038 protein 1.558 202918_s_at PREI3 preimplantation protein 3 1.558 217938_s_at KCMF1 potassium channel modulatory factor 1 1.548 212322_at SGPL1 sphingosine-1-phosphate 1 1.548 204365_s_at FLJ13110 FLJ13110 1.537 209154_at TIP-1 Tax interaction protein 1 1.537 218728_s_at HSPC163 HSPC163 protein 1.526 217898_at LOC56851 hypothetical ATG/GTP binding protein 1.526 201841_s_at HSPB1 heat shock 27kDa protein 1 1.516 213571_s_at EIF4EL3 eukaryotic translation initiation factor 4E-like 3 1.505 215813_s_at PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and ) 1.505 205778_at KLK7 " 7 (chymotryptic, )" 1.505 218018_at C21ORF124 chromosome 21 open reading frame 124 1.505 212089_at LMNA A/C 1.505 209163_at CYB561 cytochrome b-561 1.505 211202_s_at PLU-1 putative DNA/chromatin binding motif 1.495 200971_s_at SERP1 stress-associated endoplasmic reticulum protein 1 1.485 210397_at DEFB1 " defensin, beta 1" 1.485 221751_at PANK3 pantothenate kinase 3 1.485 211043_s_at CLTB " clathrin, light polypeptide (Lcb)" 1.485 214109_at LRBA " LPS-responsive vesicle trafficking, beach and anchor containing" 1.485 200660_at S100A11 S100 calcium binding protein Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

A11 (calgizzarin) 1.485 221517_s_at CRSP6 " cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa" 1.474 218171_at VPS4B vacuolar protein sorting 4B (yeast) 1.474 218252_at CKAP2 associated protein 2 1.474 215093_at H105E3 NAD(P) dependent steroid dehydrogenase-like 1.474 209080_x_at TXNL2 thioredoxin-like 2 1.474 212333_at DKFZP564F0522 DKFZP564F0522 protein 1.424 200078_s_at ATP6V0B " ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c''" 1.424 215836_s_at PCDHGC3 " protocadherin gamma subfamily C, 3" 1.424 213086_s_at CSNK1A1 " casein kinase 1, alpha 1" 1.283 215808_at KLK10 kallikrein 10 8.282 219279_at DOCK10 dedicator of cytokinesis protein 10 7.835 214677_x_at IGLJ3 immunoglobulin lambda joining 3 7.781 212592_at IGJ " immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides" 6.869 215379_x_at IGLJ3 immunoglobulin lambda joining 3 6.635 203691_at PI3 " protease inhibitor 3, skin- derived (SKALP)" 6.19 215176_x_at IGKV "immunoglobulin kappa chain variable region, clone 30" 5.464 210983_s_at MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) 5.426 215713_at FLJ23125 fis 5.426 205890_s_at UBD 5.315 217022_s_at MGC27165 MGC27165 5.278 209138_x_at IGL@ immunoglobulin lambda 5.278 205242_at CXCL13 chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) 5.028 210116_at SH2D1A " SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)" 4.532 214669_x_at EST immunoglobulin kappa chain variable like 4.377 219555_s_at BM039 uncharacterized bone marrow protein BM039 4.287 204105_s_at NRCAM neuronal cell adhesion molecule 4.257 202310_s_at COL1A1 " collagen, type I, alpha 1" 3.891 214954_at KIAA0527 KIAA0527 protein 3.758 214881_s_at UBTF " upstream binding transcription factor, RNA polymerase I" 3.681 207714_s_at SERPINH1 " serine (or cysteine) Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

proteinase inhibitor, clade H ( 47), member 1, (collagen binding protein 1)" 3.482 215121_x_at HYpothetical HYpothetical protein protein 3.458 205337_at DCT " dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)" 3.364 220664_at SPRR2C small proline-rich protein 2C 3.317 215946_x_at HYpothetical HYpothetical protein protein 3.294 211981_at COL4A1 " collagen, type IV, alpha 1" 3.294 203153_at IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.204 206914_at CRTAM class-I MHC-restricted T cell associated molecule 3.182 210072_at CCL19 chemokine (C-C motif) ligand 19 3.182 210982_s_at HLA-DRA " major histocompatibility complex, class II, DR alpha" 3.182 214536_at ARS ARS component B 3.16 210915_x_at TRB@ T cell receptor beta locus 3.16 41469_at PI3 " protease inhibitor 3, skin- derived (SKALP)" 3.095 202311_s_at COL1A1 " collagen, type I, alpha 1" 3.095 207339_s_at LTB " lymphotoxin beta (TNF superfamily, member 3)" 3.031 209879_at SELPLG selectin P ligand 3.031 201641_at BST2 bone marrow stromal cell antigen 2 3.031 201858_s_at PRG1 " proteoglycan 1, secretory granule" 3.031 214836_x_at HYpothetical HYpothetical protein protein 3.031 213954_at KIAA0888 KIAA0888 protein 2.99 213915_at NKG7 group 7 sequence 2.99 206496_at FMO3 flavin containing monooxygenase 3 2.949 211795_s_at FYB FYN binding protein (FYB- 120/130) 2.949 213160_at DOCK2 dedicator of cyto-kinesis 2 2.949 215646_s_at CSPG2 chondroitin sulfate proteoglycan 2 (versican) 2.888 204766_s_at NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 2.888 217157_x_at EST immunoglobulin kappa constant like 2.868 204475_at MMP1 matrix metalloproteinase 1 (interstitial collagenase) 2.868 205694_at TYRP1 tyrosinase-related protein 1 2.828 212670_at ELN " elastin (supravalvular aortic stenosis, Williams-Beuren syndrome)" 2.77 201085_s_at SON SON DNA binding protein Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

2.713 202901_x_at CTSS cathepsin S 2.694 202803_s_at ITGB2 " integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)" 2.639 212187_x_at PTGDS prostaglandin D2 synthase 21kDa (brain) 2.603 206504_at CYP24A1 " cytochrome P450, family 24, subfamily A, polypeptide 1" 2.603 215103_at CYP2C19 " cytochrome P450, family 2, subfamily C, polypeptide 19" 2.603 208622_s_at VIL2 villin 2 (ezrin) 2.549 215716_s_at ATP2B1 " ATPase, Ca++ transporting, plasma membrane 1" 2.514 204580_at MMP12 matrix metalloproteinase 12 (macrophage ) 2.514 219932_at SLC27A6 " solute carrier family 27 (fatty acid transporter), member 6" 2.514 203798_s_at VSNL1 visinin-like 1 2.497 206008_at TGM1 " transglutaminase 1 (K polypeptide epidermal type I, protein--gamma- glutamyltransferase)" 2.497 221729_at COL5A2 " collagen, type V, alpha 2" 2.479 204285_s_at PMAIP1 phorbol-12-myristate-13- acetate-induced protein 1 2.479 205064_at SPRR1B small proline-rich protein 1B (cornifin) 2.479 221671_x_at IGKC immunoglobulin kappa constant 2.462 208502_s_at PITX1 paired-like homeodomain transcription factor 1 2.445 215049_x_at CD163 CD163 antigen 2.445 213993_at SPON1 " spondin 1, (f-spondin) extracellular matrix protein" 2.445 203416_at CD53 CD53 antigen 2.428 210809_s_at OSF-2 osteoblast specific factor 2 (fasciclin I-like) 2.428 202575_at CRABP2 cellular retinoic acid binding protein 2 2.412 213909_at HYpothetical HYpothetical protein protein 2.395 220414_at CLSP calmodulin-like skin protein 2.378 220322_at IL1F9 " interleukin 1 family, member 9" 2.378 218730_s_at OGN " osteoglycin (osteoinductive factor, mimecan)" 2.362 205798_at IL7R interleukin 7 receptor 2.346 204897_at PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.346 205363_at BBOX1 " butyrobetaine (gamma), 2- oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1" 2.346 209686_at S100B " S100 calcium binding protein, beta (neural)" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

2.329 210413_x_at SERPINB4 " serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4" 2.313 210198_s_at PLP1 " proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)" 2.313 204955_at SRPX " sushi-repeat-containing protein, X-linked" 2.313 211734_s_at FCER1A " Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide" 2.313 219118_at FKBP11 " FK506 binding protein 11, 19 kDa" 2.313 204959_at MNDA myeloid cell nuclear differentiation antigen 2.297 202404_s_at COL1A2 " collagen, type I, alpha 2" 2.297 211742_s_at EVI2B ecotropic viral integration site 2B 2.282 204529_s_at TOX thymus high mobility group box protein TOX 2.282 218232_at C1QA " complement component 1, q subcomponent, alpha polypeptide" 2.266 204619_s_at CSPG2 chondroitin sulfate proteoglycan 2 (versican) 2.266 206315_at CRLF1 cytokine receptor-like factor 1 2.25 201688_s_at TPD52 tumor protein D52 2.235 205590_at RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 2.219 218404_at SNX10 sorting nexin 10 2.219 203535_at S100A9 S100 calcium binding protein A9 (calgranulin B) 2.219 207247_s_at ZFY " zinc finger protein, Y- linked" 2.219 206052_s_at SLBP stem-loop (histone) binding protein 2.204 219166_at C14ORF104 chromosome 14 open reading frame 104 2.204 203423_at RBP1 " retinol binding protein 1, cellular" 2.204 210279_at GPR18 G protein-coupled receptor 18 2.189 212702_s_at BICD2 coiled-coil protein BICD2 2.189 211799_x_at HLA-C " major histocompatibility complex, class I, C" 2.189 219148_at TOPK T-LAK cell-originated protein kinase 2.189 205627_at CDA 2.189 214549_x_at HYpothetical HYpothetical protein protein 2.189 266_s_at CD24 CD24 antigen (small cell lung carcinoma cluster 4 antigen) 2.189 204205_at APOBEC3G " apolipoprotein B mRNA editing enzyme, catalytic polypeptide- like 3G" 2.189 204170_s_at CKS2 CDC28 protein kinase Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

regulatory subunit 2 2.189 205891_at ADORA2B 2.173 209631_s_at GPR37 G protein-coupled receptor 37 (endothelin receptor type B- like) 2.173 206343_s_at NRG1 neuregulin 1 2.173 214580_x_at KRT6A 2.158 212624_s_at CHN1 chimerin (chimaerin) 1 2.158 209772_s_at CD24 CD24 antigen (small cell lung carcinoma cluster 4 antigen) 2.158 203779_s_at EVA1 epithelial V-like antigen 1 2.158 209125_at KRT6A keratin 6A 2.158 218542_at C10ORF3 open reading frame 3 2.144 220794_at FLJ21195 protein related to DAC and cerberus 2.144 215271_at TNN tenascin N 2.144 218876_at CGI-38 brain specific protein 2.129 204033_at TRIP13 thyroid hormone receptor interactor 13 2.114 219812_at STAG3 stromal antigen 3 2.114 204463_s_at EDNRA endothelin receptor type A 2.099 219087_at ASPN asporin (LRR class 1) 2.099 208436_s_at IRF7 interferon regulatory factor 7 2.085 204393_s_at ACPP " , prostate" 2.085 214382_at HYpothetical HYpothetical protein protein 2.071 206581_at BNC basonuclin 2.071 203028_s_at CYBA " cytochrome b-245, alpha polypeptide" 2.071 203231_s_at SCA1 " 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1)" 2.071 203021_at SLPI secretory leukocyte protease inhibitor (antileukoproteinase) 2.071 208851_s_at THY1 Thy-1 cell surface antigen 2.071 205543_at APG-1 heat shock protein (hsp110 family) 2.056 218451_at CDCP1 CUB domain-containing protein 1 2.056 217916_s_at BM-009 BM-009 2.056 203083_at THBS2 thrombospondin 2 2.056 212865_s_at COL14A1 " collagen, type XIV, alpha 1 (undulin)" 2.056 206245_s_at IVNS1ABP influenza virus NS1A binding protein 2.056 206291_at NTS neurotensin 2.042 203362_s_at MAD2L1 MAD2 mitotic arrest deficient- like 1 (yeast) 2.042 204026_s_at ZWINT ZW10 interactor 2.042 203281_s_at UBE1L ubiquitin-activating enzyme E1-like 2.042 213888_s_at DJ434O14.3 TRAF3-interacting Jun N- terminal kinase (JNK)- activating modulator 2.042 217755_at HN1 hematological and neurological expressed 1 2.042 204415_at G1P3 " interferon, alpha-inducible Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

protein (clone IFI-6-16)" 2.042 206932_at CH25H cholesterol 25-hydroxylase 2.042 209505_at NR2F1 " nuclear receptor subfamily 2, group F, member 1" 2.028 204734_at KRT15 2.028 203184_at FBN2 2 (congenital contractural arachnodactyly) 2.028 204777_s_at MAL " mal, T-cell differentiation protein" 2.028 201292_at TOP2A topoisomerase (DNA) II alpha 170kDa 2.028 211368_s_at CASP1 " caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)" 2.028 214467_at GPR65 G protein-coupled receptor 65 2.028 201617_x_at CALD1 caldesmon 1 2.014 209921_at SLC7A11 " solute carrier family 7, (cationic transporter, y+ system) member 11" 2.014 213294_at FLJ38348 FLJ38348 2.014 203570_at LOXL1 lysyl oxidase-like 1 2.014 210095_s_at IGFBP3 insulin-like growth factor binding protein 3 2.014 215034_s_at TM4SF1 transmembrane 4 superfamily member 1 2.014 208863_s_at SFRS1 " splicing factor, /serine-rich 1 (splicing factor 2, alternate splicing factor)" 2.014 215446_s_at HYpothetical HYpothetical protein protein 2 214710_s_at CCNB1 cyclin B1 2 201697_s_at DNMT1 DNA (cytosine-5-)- methyltransferase 1 2 201310_s_at C5ORF13 open reading frame 13 2 217894_at KCTD3 potassium channel tetramerisation domain containing 3 2 203932_at HLA-DMB " major histocompatibility complex, class II, DM beta" 1.986 207023_x_at KRT10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris) 1.986 202016_at MEST mesoderm specific transcript homolog (mouse) 1.986 203879_at PIK3CD " phosphoinositide-3-kinase, catalytic, delta polypeptide" 1.986 202430_s_at PLSCR1 phospholipid scramblase 1 1.986 212922_s_at SMYD2 SET and MYND domain containing 2 1.986 209053_s_at WHSC1 Wolf-Hirschhorn syndrome candidate 1 1.986 202450_s_at CTSK cathepsin K (pycnodysostosis) 1.986 204825_at MELK maternal embryonic leucine zipper kinase Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.986 202458_at SPUVE "protease, serine, 23" 1.986 201376_s_at HNRPF heterogeneous nuclear ribonucleoprotein F 1.972 205281_s_at PIGA " phosphatidylinositol glycan, class A (paroxysmal nocturnal hemoglobinuria)" 1.972 203250_at RBM16 RNA binding motif protein 16 1.972 215285_s_at PHTF1 putative homeodomain transcription factor 1 1.972 203797_at VSNL1 visinin-like 1 1.972 201930_at MCM6 " MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)" 1.972 201792_at AEBP1 AE binding protein 1 1.972 219667_s_at BANK B-cell scaffold protein with repeats 1 1.972 219032_x_at OPN3 " 3 (encephalopsin, panopsin)" 1.972 217986_s_at BAZ1A " bromodomain adjacent to zinc finger domain, 1A" 1.972 201829_at NET1 neuroepithelial cell transforming gene 1 1.959 211762_s_at KPNA2 " alpha 2 (RAG cohort 1, alpha 1)" 1.959 210325_at CD1A " CD1A antigen, a polypeptide" 1.959 212515_s_at DDX3X " DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked" 1.959 200728_at ACTR2 ARP2 actin-related protein 2 homolog (yeast) 1.959 220104_at ZAP zinc finger antiviral protein 1.959 202957_at HCLS1 hematopoietic cell-specific Lyn substrate 1 1.959 204855_at SERPINB5 " serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5" 1.959 200943_at HMGN1 high-mobility group nucleosome binding domain 1 1.945 208864_s_at TXN thioredoxin 1.945 207996_s_at C18ORF1 chromosome 18 open reading frame 1 1.945 206026_s_at TNFAIP6 " tumor necrosis factor, alpha- induced protein 6" 1.945 203185_at RASSF2 Ras association (RalGDS/AF-6) domain family 2 1.945 208306_x_at HLA-DRB4 " major histocompatibility complex, class II, DR beta 4" 1.945 212999_x_at HLA-DQB1 " major histocompatibility complex, class II, DQ beta 1" 1.945 201477_s_at RRM1 ribonucleotide reductase M1 polypeptide 1.945 219694_at FLJ11127 FLJ11127 1.932 209723_at SERPINB9 " serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9" 1.932 222288_at HYpothetical HYpothetical protein protein Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.932 206642_at DSG1 desmoglein 1 1.932 208654_s_at CD164 " CD164 antigen, sialomucin" 1.932 222223_s_at HYpothetical HYpothetical protein protein 1.932 204622_x_at NR4A2 " nuclear receptor subfamily 4, group A, member 2" 1.932 203693_s_at E2F3 E2F transcription factor 3 1.932 204905_s_at TXNDC5 thioredoxin domain containing 5 1.932 218009_s_at PRC1 protein regulator of cytokinesis 1 1.932 221911_at LOC221810 LOC221810 1.932 33304_at ISG20 interferon stimulated gene 20kDa 1.932 202307_s_at TAP1 " transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)" 1.919 204749_at NAP1L3 nucleosome assembly protein 1- like 3 1.919 201589_at SMC1L1 SMC1 structural maintenance of chromosomes 1-like 1 (yeast) 1.919 211339_s_at ITK IL2-inducible T-cell kinase 1.919 203214_x_at CDC2 " cell division cycle 2, G1 to S and G2 to M" 1.919 208539_x_at SPRR2B small proline-rich protein 2B 1.919 218519_at SLC35A5 " solute carrier family 35, member A5" 1.919 213416_at ITGA4 " integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)" 1.919 208643_s_at XRCC5 " X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand- break rejoining; Ku autoantigen, 80kDa)" 1.919 208950_s_at ALDH7A1 " aldehyde dehydrogenase 7 family, member A1" 1.919 203559_s_at ABP1 amiloride binding protein 1 (amine oxidase (- containing)) 1.919 204407_at TTF2 " transcription termination factor, RNA polymerase II" 1.919 214453_s_at IFI44 interferon-induced protein 44 1.905 200729_s_at ACTR2 ARP2 actin-related protein 2 homolog (yeast) 1.905 206420_at IGSF6 " immunoglobulin superfamily, member 6" 1.905 201586_s_at SFPQ splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 1.905 218236_s_at PRKCN " protein kinase C, nu" 1.905 204912_at IL10RA " interleukin 10 receptor, alpha" 1.905 205014_at HBP17 heparin-binding growth factor binding protein 1.905 209572_s_at EED embryonic ectoderm development Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.905 218313_s_at GALNT7 UDP-N-acetyl-alpha-D- galactosamine:polypeptide N- acetylgalactosaminyltransferase 7 (GalNAc-T7) 1.905 209960_at HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.905 209421_at MSH2 " mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)" 1.905 212268_at SERPINB1 " serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1" 1.892 209869_at ADRA2A " adrenergic, alpha-2A-, receptor" 1.892 209387_s_at TM4SF1 transmembrane 4 superfamily member 1 1.892 221796_at HYpothetical HYpothetical protein protein 1.892 201151_s_at MBNL1 muscleblind-like (Drosophila) 1.892 204244_s_at ASK activator of S phase kinase 1.892 213918_s_at IDN3 IDN3 protein 1.892 207386_at CYP7B1 " cytochrome P450, family 7, subfamily B, polypeptide 1" 1.892 204159_at CDKN2C " cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)" 1.892 206102_at KIAA0186 KIAA0186 gene product 1.892 218737_at SBNO1 " sno, strawberry notch homolog 1 (Drosophila)" 1.892 206101_at ECM2 " extracellular matrix protein 2, female organ and adipocyte specific" 1.892 205987_at CD1C " CD1C antigen, c polypeptide" 1.879 218979_at FLJ12888 FLJ12888 1.879 201431_s_at DPYSL3 -like 3 1.879 211361_s_at SERPINB13 " serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13" 1.879 218355_at KIF4A family member 4A 1.879 200892_s_at SFRS10 " splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)" 1.879 212918_at FLJ22028 FLJ22028 1.879 208808_s_at HMGB2 high-mobility group box 2 1.879 208747_s_at C1S " complement component 1, s subcomponent" 1.879 212942_s_at KIAA1199 KIAA1199 protein 1.879 201820_at KRT5 " (epidermolysis bullosa simplex, Dowling- Meara/Kobner/Weber-Cockayne types)" 1.879 212126_at CBX5 " chromobox homolog 5 (HP1 alpha homolog, Drosophila)" 1.879 200853_at H2AFZ " H2A histone family, member Z" 1.866 202635_s_at POLR2K " polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.866 204748_at PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.866 209529_at PPAP2C phosphatidic acid phosphatase type 2C 1.866 220201_at MNAB membrane-associated nucleic acid binding protein 1.866 213943_at TWIST1 twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) 1.866 204240_s_at SMC2L1 SMC2 structural maintenance of chromosomes 2-like 1 (yeast) 1.866 203432_at TMPO thymopoietin 1.866 212546_s_at KIAA0826 KIAA0826 protein 1.866 200072_s_at HNRPM heterogeneous nuclear ribonucleoprotein M 1.866 202995_s_at FBLN1 fibulin 1 1.853 219493_at SHCBP1 likely ortholog of mouse Shc SH2-domain binding protein 1 1.853 201118_at PGD phosphogluconate dehydrogenase 1.853 217764_s_at RAB31 " RAB31, member RAS oncogene family" 1.853 200881_s_at DNAJA1 " DnaJ (Hsp40) homolog, subfamily A, member 1" 1.853 200953_s_at CCND2 cyclin D2 1.853 217870_s_at UMP-CMPK UMP-CMP kinase 1.853 218172_s_at MGC3067 MGC3067 1.84 209570_s_at D4S234E DNA segment on chromosome 4 (unique) 234 expressed sequence 1.84 204972_at OAS2 " 2'-5'-oligoadenylate synthetase 2, 69/71kDa" 1.84 201014_s_at PAICS " phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase" 1.84 204203_at CEBPG " CCAAT/enhancer binding protein (C/EBP), gamma" 1.84 217832_at NSAP1 NS1-associated protein 1 1.84 203755_at BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) 1.84 213125_at DKFZP586L151 DKFZP586L151 protein 1.84 216640_s_at P5 protein disulfide isomerase- related protein 1.84 206332_s_at IFI16 " interferon, gamma-inducible protein 16" 1.84 218350_s_at GMNN " geminin, DNA replication inhibitor" 1.84 201577_at NME1 " non-metastatic cells 1, protein (NM23A) expressed in" 1.84 206682_at HYpothetical HYpothetical protein protein 1.84 201743_at CD14 CD14 antigen 1.84 205159_at CSF2RB " colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.84 201209_at HDAC1 1 1.84 207691_x_at ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 1.84 219055_at FLJ10379 FLJ10379 1.84 203851_at IGFBP6 insulin-like growth factor binding protein 6 1.84 201110_s_at THBS1 thrombospondin 1 1.828 210059_s_at MAPK13 mitogen-activated protein kinase 13 1.828 200903_s_at AHCY S-adenosylhomocysteine hydrolase 1.828 219529_at CLIC3 chloride intracellular channel 3 1.828 213047_x_at SET SET translocation (myeloid leukemia-associated) 1.828 200783_s_at STMN1 1/oncoprotein 18 1.828 209546_s_at APOL1 " apolipoprotein L, 1" 1.828 219410_at FLJ10134 FLJ10134 1.828 206481_s_at LDB2 LIM domain binding 2 1.828 213194_at ROBO1 " roundabout, axon guidance receptor, homolog 1 (Drosophila)" 1.828 215506_s_at ARHI " ras homolog gene family, member I" 1.815 205379_at CBR3 carbonyl reductase 3 1.815 217838_s_at EVL Enah/Vasp-like 1.815 208156_x_at EPPK1 epiplakin 1 1.815 204646_at DPYD dihydropyrimidine dehydrogenase 1.815 206542_s_at SMARCA2 " SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2" 1.815 217763_s_at RAB31 " RAB31, member RAS oncogene family" 1.815 200736_s_at GPX1 peroxidase 1 1.803 203903_s_at HEPH hephaestin 1.803 212378_at GART " phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" 1.803 200644_at MLP MARCKS-like protein 1.803 201202_at PCNA proliferating cell nuclear antigen 1.803 214063_s_at TF transferrin 1.803 222077_s_at RACGAP1 Rac GTPase activating protein 1 1.803 202286_s_at TACSTD2 tumor-associated calcium signal transducer 2 1.803 220172_at FLJ13096 FLJ13096 1.803 220723_s_at FLJ21511 FLJ21511 1.803 204215_at C7ORF23 chromosome 7 open reading frame 23 1.803 209604_s_at GATA3 GATA binding protein 3 1.79 210705_s_at TRIM5 tripartite motif-containing 5 Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.79 203780_at EVA1 epithelial V-like antigen 1 1.79 208606_s_at WNT4 " wingless-type MMTV integration site family, member 4" 1.79 202431_s_at MYC v-myc myelocytomatosis viral oncogene homolog (avian) 1.79 206809_s_at HYpothetical HYpothetical protein protein 1.79 203382_s_at APOE apolipoprotein E 1.79 210559_s_at CDC2 " cell division cycle 2, G1 to S and G2 to M" 1.79 219485_s_at PSMD10 " proteasome (prosome, macropain) 26S subunit, non- ATPase, 10" 1.79 203207_s_at CHPPR likely ortholog of chicken chondrocyte protein with a poly-proline region 1.79 213290_at COL6A2 " collagen, type VI, alpha 2" 1.778 200862_at DHCR24 24-dehydrocholesterol reductase 1.778 205091_x_at RECQL RecQ protein-like (DNA helicase Q1-like) 1.778 202746_at ITM2A integral membrane protein 2A 1.778 205681_at BCL2A1 BCL2-related protein A1 1.778 202403_s_at COL1A2 " collagen, type I, alpha 2" 1.778 205174_s_at QPCT glutaminyl- cyclotransferase (glutaminyl cyclase) 1.778 208838_at TIP120A TBP-interacting protein 1.778 206011_at CASP1 " caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)" 1.778 200605_s_at PRKAR1A " protein kinase, cAMP- dependent, regulatory, type I, alpha (tissue specific extinguisher 1)" 1.778 211161_s_at HYpothetical HYpothetical protein protein 1.778 201179_s_at GNAI3 " guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3" 1.778 204114_at NID2 nidogen 2 (osteonidogen) 1.778 220643_s_at FAIM Fas apoptotic inhibitory molecule 1.778 218095_s_at TPARL TPA regulated locus 1.778 216942_s_at CD58 " CD58 antigen, (lymphocyte function-associated antigen 3)" 1.778 200606_at DSP 1.778 212058_at SR140 U2-associated SR140 protein 1.765 204517_at PPIC peptidylprolyl isomerase C (cyclophilin C) 1.765 218477_at TMEM14A transmembrane protein 14A 1.765 210592_s_at SAT spermidine/spermine N1- acetyltransferase 1.765 205381_at LRRC17 leucine rich repeat containing 17 Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.765 204118_at CD48 CD48 antigen (B-cell membrane protein) 1.765 202597_at IRF6 interferon regulatory factor 6 1.765 217966_s_at C1ORF24 chromosome 1 open reading frame 24 1.765 221541_at DKFZP434B044 DKFZp434B044 1.765 204834_at FGL2 fibrinogen-like 2 1.765 39582_at CYLD cylindromatosis (turban tumor syndrome) 1.765 214812_s_at DIP2 disco-interacting protein 2 (Drosophila) homolog 1.765 203287_at LAD1 ladinin 1 1.765 208091_s_at DKFZP564K0822 DKFZp564K0822 1.765 209092_s_at CGI-150 CGI-150 protein 1.765 204949_at ICAM3 intercellular adhesion molecule 3 1.765 214141_x_at SFRS7 " splicing factor, arginine/serine-rich 7, 35kDa" 1.765 202666_s_at BAF53A BAF53 1.753 201943_s_at CPD carboxypeptidase D 1.753 206125_s_at KLK8 (neuropsin/ovasin) 1.753 203554_x_at PTTG1 pituitary tumor-transforming 1 1.753 202157_s_at CUGBP2 " CUG triplet repeat, RNA binding protein 2" 1.753 212364_at MYO1B myosin IB 1.753 201297_s_at C2ORF6 open reading frame 6 1.753 206025_s_at TNFAIP6 " tumor necrosis factor, alpha- induced protein 6" 1.753 202524_s_at SPOCK2 " sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2" 1.753 209507_at RPA3 " replication protein A3, 14kDa" 1.753 218100_s_at ESRRBL1 estrogen-related receptor beta like 1 1.753 212138_at KIAA0648 KIAA0648 protein 1.753 209194_at CETN2 " centrin, EF-hand protein, 2" 1.753 202900_s_at NUP88 nucleoporin 88kDa 1.753 204268_at S100A2 S100 calcium binding protein A2 1.753 201473_at JUNB jun B proto-oncogene 1.753 204146_at PIR51 RAD51-interacting protein 1.753 215165_x_at UMPS uridine monophosphate synthetase (orotate phosphoribosyl and orotidine-5'-decarboxylase) 1.753 217744_s_at PIGPC1 p53-induced protein PIGPC1 1.753 209610_s_at SLC1A4 " solute carrier family 1 (glutamate/neutral amino acid transporter), member 4" 1.753 222262_s_at EKI1 ethanolamine kinase 1.753 204220_at GMFG " glia maturation factor, gamma" 1.753 200806_s_at HSPD1 heat shock 60kDa protein 1 () Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.753 208802_at SRP72 signal recognition particle 72kDa 1.753 200889_s_at SSR1 " signal sequence receptor, alpha (translocon-associated protein alpha)" 1.753 201478_s_at DKC1 " dyskeratosis congenita 1, dyskerin" 1.741 219648_at FLJ10116 FLJ10116 1.741 202228_s_at SDFR1 stromal cell derived factor receptor 1 1.741 202899_s_at SFRS3 " splicing factor, arginine/serine-rich 3" 1.741 221510_s_at GLS 1.741 202998_s_at LOXL2 lysyl oxidase-like 2 1.741 218802_at FLJ20647 FLJ20647 1.741 202375_at SEC24D " SEC24 related gene family, member D (S. cerevisiae)" 1.741 209028_s_at SSH3BP1 SH3 domain binding protein 1 1.741 205027_s_at MAP3K8 mitogen-activated protein kinase kinase kinase 8 1.729 215464_s_at TIP-1 Tax interaction protein 1 1.729 202820_at AHR aryl hydrocarbon receptor 1.729 212460_at C14ORF147 chromosome 14 open reading frame 147 1.729 211529_x_at HLA-A " major histocompatibility complex, class I, A" 1.729 203411_s_at LMNA lamin A/C 1.729 201765_s_at HEXA A (alpha polypeptide) 1.729 209101_at CTGF connective tissue growth factor 1.729 219399_at LIN7C lin-7 homolog C (C. elegans) 1.729 217956_s_at MASA E-1 enzyme 1.729 201662_s_at FACL3 " fatty-acid-Coenzyme A , long-chain 3" 1.729 204846_at CP ceruloplasmin (ferroxidase) 1.729 209292_at ID4 " inhibitor of DNA binding 4, dominant negative helix-loop- helix protein" 1.729 212978_at TA-LRRP T-cell activation leucine repeat-rich protein 1.729 207565_s_at MR1 " major histocompatibility complex, class I-related" 1.729 201170_s_at BHLHB2 " basic helix-loop-helix domain containing, class B, 2" 1.729 208639_x_at P5 protein disulfide isomerase- related protein 1.729 203721_s_at CGI-48 CGI-48 protein 1.729 208910_s_at C1QBP " complement component 1, q subcomponent binding protein" 1.729 213746_s_at FLNA " A, alpha (actin binding protein 280)" 1.729 201015_s_at JUP junction 1.729 200944_s_at HMGN1 high-mobility group nucleosome binding domain 1 1.729 201444_s_at ATP6AP2 " ATPase, H+ transporting, Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

lysosomal accessory protein 2" 1.717 201897_s_at CKS1B CDC28 protein kinase regulatory subunit 1B 1.717 222294_s_at RAB27A " RAB27A, member RAS oncogene family" 1.717 207002_s_at PLAGL1 pleiomorphic adenoma gene-like 1 1.717 209623_at MCCC2 methylcrotonoyl-Coenzyme A carboxylase 2 (beta) 1.717 204516_at SCA7 spinocerebellar ataxia 7 (olivopontocerebellar atrophy with retinal degeneration) 1.717 213004_at ANGPTL2 angiopoietin-like 2 1.717 202555_s_at MYLK " myosin, light polypeptide kinase" 1.717 201180_s_at GNAI3 " guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3" 1.717 212658_at LHFPL2 lipoma HMGIC fusion partner- like 2 1.717 200599_s_at TRA1 tumor rejection antigen (gp96) 1 1.717 201215_at PLS3 plastin 3 (T isoform) 1.717 203178_at GATM amidinotransferase (L- arginine:glycine amidinotransferase) 1.717 208966_x_at IFI16 " interferon, gamma-inducible protein 16" 1.717 212919_at DCP2 decapping enzyme hDcp2 1.717 218396_at FLJ20136 FLJ20136 1.717 211343_s_at COL13A1 " collagen, type XIII, alpha 1" 1.717 202119_s_at CPNE3 copine III 1.717 202589_at TYMS thymidylate synthetase 1.717 201505_at LAMB1 " laminin, beta 1" 1.717 203324_s_at CAV2 caveolin 2 1.705 221776_s_at BRD7 bromodomain containing 7 1.705 206989_s_at SFRS2IP " splicing factor, arginine/serine-rich 2, interacting protein" 1.705 201291_s_at TOP2A topoisomerase (DNA) II alpha 170kDa 1.705 212799_at STX6 syntaxin 6 1.705 209476_at TXNDC thioredoxin domain containing 1.705 218901_at PLSCR4 phospholipid scramblase 4 1.705 207983_s_at STAG2 stromal antigen 2 1.705 213424_at KIAA0895 KIAA0895 protein 1.705 206637_at GPR105 G protein-coupled receptor 105 1.705 202664_at WASPIP Wiskott-Aldrich syndrome protein interacting protein 1.705 201185_at PRSS11 " protease, serine, 11 (IGF binding)" 1.705 208636_at HYpothetical HYpothetical protein protein 1.705 221505_at ANP32E " acidic (leucine-rich) nuclear phosphoprotein 32 family, member E" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.705 208612_at GRP58 " glucose regulated protein, 58kDa" 1.705 204194_at BACH1 " BTB and CNC homology 1, basic leucine zipper transcription factor 1" 1.705 220202_s_at MNAB membrane-associated nucleic acid binding protein 1.705 206032_at DSC3 desmocollin 3 1.705 210105_s_at FYN " FYN oncogene related to SRC, FGR, YES" 1.705 213984_at KIAA0648 KIAA0648 protein 1.705 201954_at ARPC1B " actin related protein 2/3 complex, subunit 1B, 41kDa" 1.693 201845_s_at RYBP RING1 and YY1 binding protein 1.693 210293_s_at SEC23B Sec23 homolog B (S. cerevisiae) 1.693 220432_s_at CYP39A1 " cytochrome P450, family 39, subfamily A, polypeptide 1" 1.693 215691_x_at LOC51668 HSPCO34 protein 1.693 211932_at HYpothetical HYpothetical protein protein 1.693 208018_s_at HCK hemopoietic cell kinase 1.693 217743_s_at C6ORF67 open reading frame 67 1.693 205241_at SCO2 SCO cytochrome oxidase deficient homolog 2 (yeast) 1.693 202619_s_at PLOD2 " procollagen-lysine, 2- oxoglutarate 5-dioxygenase (lysine hydroxylase) 2" 1.693 214058_at MYCL1 " v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)" 1.693 221698_s_at CLECSF12 " C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12" 1.693 215073_s_at NR2F2 " nuclear receptor subfamily 2, group F, member 2" 1.693 213175_s_at SNRPB small nuclear ribonucleoprotein polypeptides B and B1 1.693 221795_at HYpothetical HYpothetical protein protein 1.693 202225_at CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 1.693 202963_at RFX5 " regulatory , 5 (influences HLA class II expression)" 1.693 212012_at D2S448 Melanoma associated gene 1.693 204995_at CDK5R1 " cyclin-dependent kinase 5, regulatory subunit 1 (p35)" 1.693 204036_at EDG2 " endothelial differentiation, G- protein-coupled receptor, 2" 1.682 212414_s_at 6-Sep septin 6 1.682 202107_s_at MCM2 " MCM2 minichromosome maintenance deficient 2, Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

mitotin (S. cerevisiae)" 1.682 219347_at MTH2 likely ortholog of mouse MutT homolog 2 1.682 213911_s_at H2AFZ " H2A histone family, member Z" 1.682 219764_at FZD10 homolog 10 (Drosophila) 1.682 217362_x_at HYpothetical HYpothetical protein protein 1.682 205863_at S100A12 S100 calcium binding protein A12 (calgranulin C) 1.682 201532_at PSMA3 " proteasome (prosome, macropain) subunit, alpha type, 3" 1.682 200662_s_at TOMM20 of outer mitochondrial membrane 20 (yeast) homolog 1.682 208637_x_at ACTN1 " , alpha 1" 1.682 208766_s_at HNRPR heterogeneous nuclear ribonucleoprotein R 1.682 213725_x_at LOC283824 LOC283824 1.682 200929_at TMP21 transmembrane trafficking protein 1.682 213905_x_at SDCCAG33 serologically defined colon cancer antigen 33 1.682 200824_at GSTP1 glutathione S-transferase pi 1.682 205263_at BCL10 B-cell CLL/lymphoma 10 1.682 219570_at C20ORF23 open reading frame 23 1.682 218231_at NAGK N-acetylglucosamine kinase 1.682 201976_s_at MYO10 myosin X 1.682 211675_s_at HIC I-mfa domain-containing protein 1.682 64486_at CORO1B " coronin, actin binding protein, 1B" 1.682 203404_at ALEX2 armadillo repeat protein ALEX2 1.682 202722_s_at GFPT1 glutamine-fructose-6-phosphate 1 1.67 204035_at SCG2 secretogranin II (chromogranin C) 1.67 201772_at OAZIN antizyme inhibitor 1.67 209863_s_at TP73L tumor protein p73-like 1.67 209150_s_at TM9SF1 transmembrane 9 superfamily member 1 1.67 211911_x_at HLA-B " major histocompatibility complex, class I, B" 1.67 213789_at EBP emopamil binding protein (sterol isomerase) 1.67 217165_x_at MT1F metallothionein 1F (functional) 1.67 217800_s_at NDFIP1 Nedd4 family interacting protein 1 1.67 220428_at CD207 " CD207 antigen, langerin" 1.67 201847_at LIPA " A, lysosomal acid, cholesterol esterase (Wolman disease)" 1.67 201415_at GSS 1.67 213848_at DUSP7 dual specificity phosphatase 7 Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.67 213088_s_at DNAJC9 " DnaJ (Hsp40) homolog, subfamily C, member 9" 1.67 211366_x_at CASP1 " caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)" 1.67 209043_at PAPSS1 3'-phosphoadenosine 5'- phosphosulfate synthase 1 1.67 218088_s_at RRAGC Ras-related GTP binding C 1.67 200890_s_at HYpothetical HYpothetical protein protein 1.67 207168_s_at H2AFY " H2A histone family, member Y" 1.67 202985_s_at BAG5 BCL2-associated athanogene 5 1.67 202888_s_at ANPEP " alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)" 1.67 202703_at DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1- interacting) 1.67 207738_s_at NCKAP1 NCK-associated protein 1 1.67 210053_at MGC14697 upregulated during skeletal muscle growth 5 1.659 206584_at LY96 lymphocyte antigen 96 1.659 205783_at KLK13 1.659 214214_s_at C1QBP " complement component 1, q subcomponent binding protein" 1.659 221816_s_at PHF11 PHD finger protein 11 1.659 221923_s_at NPM1 " nucleophosmin (nucleolar phosphoprotein B23, numatrin)" 1.659 202012_s_at EXT2 exostoses (multiple) 2 1.659 204333_s_at AGA 1.659 201363_s_at IVNS1ABP influenza virus NS1A binding protein 1.659 211737_x_at PTN " pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)" 1.659 211747_s_at LSM5 " LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)" 1.659 204455_at BPAG1 " bullous pemphigoid antigen 1, 230/240kDa" 1.659 201990_s_at CREBL2 cAMP responsive element binding protein-like 2 1.659 202606_s_at TLK1 tousled-like kinase 1 1.659 202933_s_at YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 1.659 218803_at CHFR checkpoint with forkhead and ring finger domains 1.659 200693_at YWHAQ " tyrosine 3- monooxygenase/tryptophan 5- monooxygenase activation protein, theta polypeptide" 1.659 201998_at SIAT1 " sialyltransferase 1 (beta- galactoside alpha-2,6- sialyltransferase)" 1.659 210889_s_at FCGR2B " Fc fragment of IgG, low affinity IIb, receptor for Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

(CD32)" 1.659 218622_at NUP37 nucleoporin Nup37 1.659 203415_at PDCD6 programmed cell death 6 1.659 200797_s_at MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 1.659 202615_at GNAQ " guanine nucleotide binding protein (G protein), q polypeptide" 1.659 218989_x_at SLC30A5 " solute carrier family 30 (zinc transporter), member 5" 1.659 222242_s_at KLK5 kallikrein 5 1.659 200665_s_at SPARC " secreted protein, acidic, cysteine-rich (osteonectin)" 1.659 203209_at RFC5 " replication factor C (activator 1) 5, 36.5kDa" 1.647 210092_at MAGOH " mago-nashi homolog, proliferation-associated (Drosophila)" 1.647 210633_x_at KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris) 1.647 213119_at SLC36A1 " solute carrier family 36 (proton/amino acid symporter), member 1" 1.647 212989_at MOB mob protein 1.647 212983_at HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 1.647 211564_s_at RIL LIM domain protein 1.647 200666_s_at DNAJB1 " DnaJ (Hsp40) homolog, subfamily B, member 1" 1.647 207483_s_at TIP120A TBP-interacting protein 1.647 201787_at FBLN1 fibulin 1 1.647 213425_at WNT5A " wingless-type MMTV integration site family, member 5A" 1.647 201112_s_at CSE1L CSE1 chromosome segregation 1- like (yeast) 1.647 218156_s_at FLJ10534 FLJ10534 1.647 203594_at RTCD1 RTC domain containing 1 1.647 219540_at ZNF267 zinc finger protein 267 1.647 201063_at RCN1 " reticulocalbin 1, EF-hand calcium binding domain" 1.647 209970_x_at CASP1 " caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)" 1.647 201298_s_at C2ORF6 chromosome 2 open reading frame 6 1.647 203060_s_at PAPSS2 3'-phosphoadenosine 5'- phosphosulfate synthase 2 1.647 212086_x_at LMNA lamin A/C 1.647 211962_s_at ZFP36L1 " zinc finger protein 36, C3H type-like 1" 1.647 203344_s_at RBBP8 retinoblastoma binding protein 8 1.647 203961_at NEBL nebulette 1.647 207165_at HMMR hyaluronan-mediated motility receptor (RHAMM) Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.647 218040_at FLJ10330 FLJ10330 1.647 221875_x_at HLA-F " major histocompatibility complex, class I, F" 1.647 214321_at NOV nephroblastoma overexpressed gene 1.647 219649_at ALG6 " -linked glycosylation 6 homolog (yeast, alpha-1,3-glucosyltransferase)" 1.636 217523_at CD44 CD44 antigen (homing function and Indian blood group system) 1.636 222035_s_at PAPOLA poly(A) polymerase alpha 1.636 202540_s_at HMGCR 3-hydroxy-3-methylglutaryl- Coenzyme A reductase 1.636 200014_s_at HNRPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 1.636 219161_s_at CKLF chemokine-like factor 1.636 218543_s_at FLJ22693 FLJ22693 1.636 212640_at LOC201562 LOC201562 1.636 206023_at NMU neuromedin U 1.636 202857_at TMEM4 transmembrane protein 4 1.636 201515_s_at TSN translin 1.636 201261_x_at BGN biglycan 1.636 201479_at DKC1 " dyskeratosis congenita 1, dyskerin" 1.636 205128_x_at PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.636 203460_s_at PSEN1 presenilin 1 (Alzheimer disease 3) 1.636 221556_at CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 1.636 204438_at MRC1 " mannose receptor, C type 1" 1.636 212043_at TGOLN2 trans-golgi network protein 2 1.636 52255_s_at COL5A3 " collagen, type V, alpha 3" 1.636 208978_at CRIP2 cysteine-rich protein 2 1.636 217850_at NS nucleostemin 1.636 200700_s_at KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 1.636 213454_at CORT cortistatin 1.636 201325_s_at EMP1 epithelial membrane protein 1 1.636 203987_at FZD6 frizzled homolog 6 (Drosophila) 1.636 205292_s_at HNRPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 1.636 201795_at LBR lamin B receptor 1.636 201734_at CLCN3 chloride channel 3 1.625 221841_s_at KLF4 Kruppel-like factor 4 (gut) 1.625 201726_at ELAVL1 " ELAV (embryonic lethal, abnormal vision, Drosophila)- like 1 (Hu antigen R)" 1.625 202659_at PSMB10 " proteasome (prosome, macropain) subunit, beta type, 10" 1.625 201436_at EIF4E eukaryotic translation initiation factor 4E 1.625 218140_x_at APMCF1 APMCF1 protein Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.625 221782_at ERDJ5 ER-resident protein ERdj5 1.625 202729_s_at LTBP1 latent transforming growth factor beta binding protein 1 1.625 212867_at HYpothetical HYpothetical protein protein 1.625 221983_at MGC3035 MGC3035 1.625 202777_at SHOC2 soc-2 suppressor of clear homolog (C. elegans) 1.625 208788_at ELOVL5 " ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3- like, yeast)" 1.625 204136_at COL7A1 " collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)" 1.625 218830_at RPL26L1 ribosomal protein L26-like 1 1.625 208837_at P24B integral type I protein 1.625 202780_at OXCT 3-oxoacid CoA transferase 1.625 214697_s_at ROD1 ROD1 regulator of differentiation 1 (S. pombe) 1.625 209393_s_at EIF4EL3 eukaryotic translation initiation factor 4E-like 3 1.613 212885_at MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 1.613 206227_at CILP " cartilage intermediate layer protein, nucleotide pyrophosphohydrolase" 1.613 200968_s_at PPIB peptidylprolyl isomerase B (cyclophilin B) 1.613 201594_s_at PPP4R1 " 4, regulatory subunit 1" 1.613 219296_at HIP14L HIP14-related protein 1.613 201013_s_at PAICS " phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase" 1.613 201457_x_at BUB3 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 1.613 201330_at RARS arginyl-tRNA synthetase 1.613 200750_s_at " RAN, member RAS oncogene family" 1.613 202706_s_at UMPS uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) 1.613 201666_at TIMP1 " tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)" 1.613 212372_at MYH10 " myosin, heavy polypeptide 10, non-muscle" 1.613 212687_at LIMS1 LIM and senescent cell antigen-like domains 1 1.613 217525_at HYpothetical HYpothetical protein Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

protein 1.613 221676_s_at CORO1C " coronin, actin binding protein, 1C" 1.613 200627_at TEBP "unactive progesterone receptor, 23 kD" 1.613 217919_s_at MRPL42 mitochondrial ribosomal protein L42 1.613 218039_at ANKT nucleolar and spindle associated protein 1 1.613 203968_s_at CDC6 CDC6 cell division cycle 6 homolog (S. cerevisiae) 1.613 203414_at MMD monocyte to macrophage differentiation-associated 1.613 202816_s_at SS18 " synovial sarcoma translocation, chromosome 18" 1.613 203313_s_at TGIF TGFB-induced factor (TALE family homeobox) 1.613 210840_s_at IQGAP1 IQ motif containing GTPase activating protein 1 1.613 218474_s_at FLJ20040 potassium channel tetramerisation domain containing 5 1.613 203077_s_at MADH2 " MAD, mothers against decapentaplegic homolog 2 (Drosophila)" 1.613 213572_s_at SERPINB1 " serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1" 1.613 201016_at EIF1A eukaryotic translation initiation factor 1A 1.613 201494_at PRCP prolylcarboxypeptidase (angiotensinase C) 1.613 201307_at FLJ10849 FLJ10849 1.613 220924_s_at SLC38A2 " solute carrier family 38, member 2" 1.602 203741_s_at ADCY7 adenylate cyclase 7 1.602 200595_s_at EIF3S10 " eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa" 1.602 202386_s_at LKAP limkain b1 1.602 202246_s_at CDK4 cyclin-dependent kinase 4 1.602 201695_s_at NP nucleoside phosphorylase 1.602 213279_at DHRS1 dehydrogenase/reductase (SDR family) member 1 1.602 211711_s_at PTEN phosphatase and tensin homolog (mutated in multiple advanced 1) 1.602 212247_at C7ORF14 chromosome 7 open reading frame 14 1.602 211744_s_at CD58 " CD58 antigen, (lymphocyte function-associated antigen 3)" 1.602 203008_x_at APACD ATP binding protein associated with cell differentiation 1.602 200011_s_at ARF3 ADP-ribosylation factor 3 1.602 39248_at AQP3 aquaporin 3 1.602 208002_s_at BACH brain acyl-CoA hydrolase 1.602 203302_at DCK deoxycytidine kinase Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.602 201416_at SOX4 SRY (sex determining region Y)-box 4 1.602 212461_at OAZIN ornithine decarboxylase antizyme inhibitor 1.602 213616_at DKFZP586M1523 DKFZP586M1523 protein 1.602 218041_x_at SLC38A2 " solute carrier family 38, member 2" 1.602 203689_s_at FMR1 fragile X mental retardation 1 1.602 204171_at RPS6KB1 " ribosomal protein S6 kinase, 70kDa, polypeptide 1" 1.602 202232_s_at GA17 dendritic cell protein 1.602 208877_at PAK2 p21 (CDKN1A)-activated kinase 2 1.602 209389_x_at DBI " diazepam binding inhibitor (GABA receptor modulator, acyl- Coenzyme A binding protein)" 1.602 202059_s_at KPNA1 karyopherin alpha 1 (importin alpha 5) 1.602 209270_at LAMB3 " laminin, beta 3" 1.602 200791_s_at IQGAP1 IQ motif containing GTPase activating protein 1 1.602 209762_x_at SP110 SP110 nuclear body protein 1.602 202180_s_at MVP major vault protein 1.602 220933_s_at FLJ13409 FLJ13409 1.602 213923_at RAP2B " RAP2B, member of RAS oncogene family" 1.591 202239_at ADPRTL1 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)- like 1 1.591 202241_at C8FW phosphoprotein regulated by mitogenic pathways 1.591 217901_at DSG2 desmoglein 2 1.591 208689_s_at RPN2 ribophorin II 1.591 212591_at KIAA0117 KIAA0117 protein 1.591 200893_at SFRS10 " splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)" 1.591 207030_s_at CSRP2 cysteine and glycine-rich protein 2 1.591 211967_at PORIMIN pro-oncosis receptor inducing membrane injury gene 1.591 208511_at PTTG1 pituitary tumor-transforming 1 1.591 203359_s_at MYCBP c-myc binding protein 1.591 209279_s_at H105E3 NAD(P) dependent steroid dehydrogenase-like 1.591 212486_s_at FYN " FYN oncogene related to SRC, FGR, YES" 1.591 214315_x_at CALR 1.591 208642_s_at XRCC5 " X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand- break rejoining; Ku autoantigen, 80kDa)" 1.591 214882_s_at SFRS2 " splicing factor, arginine/serine-rich 2" 1.591 208743_s_at YWHAB " tyrosine 3- Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

monooxygenase/tryptophan 5- monooxygenase activation protein, beta polypeptide" 1.591 204342_at DKFZP586G0123 calcium-binding transporter 1.591 203824_at TM4SF3 transmembrane 4 superfamily member 3 1.591 202168_at TAF9 " TAF9 RNA polymerase II, TATA box binding protein (TBP)- associated factor, 32kDa" 1.591 213568_at OSR2 odd-skipped-related 2A protein 1.591 213285_at LOC161291 LOC161291 1.591 211964_at COL4A2 " collagen, type IV, alpha 2" 1.591 214085_x_at HRB2 HIV-1 rev binding protein 2 1.591 201608_s_at PWP1 nuclear phosphoprotein similar to S. cerevisiae PWP1 1.591 203203_s_at HRB2 HIV-1 rev binding protein 2 1.591 212175_s_at AK2 adenylate kinase 2 1.591 209678_s_at PRKCI " protein kinase C, iota" 1.591 200942_s_at HSBP1 heat shock factor binding protein 1 1.591 209326_at SLC35A2 " solute carrier family 35 (UDP-galactose transporter), member A2" 1.58 203752_s_at JUND jun D proto-oncogene 1.58 204119_s_at ADK adenosine kinase 1.58 213287_s_at KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris) 1.58 219321_at MPP5 " membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)" 1.58 212371_at PNAS-4 CGI-146 protein 1.58 200058_s_at U5-200KD "U5 snRNP-specific protein, 200-KD" 1.58 211758_x_at APACD ATP binding protein associated with cell differentiation 1.58 209763_at NRLN1 neuralin 1 1.58 208752_x_at NAP1L1 nucleosome assembly protein 1- like 1 1.58 218123_at C21ORF59 chromosome 21 open reading frame 59 1.58 208944_at TGFBR2 " transforming growth factor, beta receptor II (70/80kDa)" 1.58 208540_x_at HYpothetical HYpothetical protein protein 1.58 201948_at HUMAUANTIG nucleolar GTPase 1.58 209023_s_at STAG2 stromal antigen 2 1.58 209130_at SNAP23 " synaptosomal-associated protein, 23kDa" 1.58 220547_s_at MGC5560 MGC5560 1.58 201136_at PLP2 proteolipid protein 2 (colonic -enriched) 1.58 208675_s_at DDOST dolichyl- diphosphooligosaccharide- protein glycosyltransferase 1.58 209541_at IGF1 insulin-like growth factor 1 (somatomedin C) Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.58 212956_at KIAA0882 KIAA0882 protein 1.58 209796_s_at TMEM4 transmembrane protein 4 1.58 207057_at SLC16A7 " solute carrier family 16 (monocarboxylic acid transporters), member 7" 1.569 208787_at MRPL3 mitochondrial ribosomal protein L3 1.569 219225_at PGBD5 piggyBac transposable element derived 5 1.569 209466_x_at PTN " pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)" 1.569 213405_at RAB22A " RAB22A, member RAS oncogene family" 1.569 209868_s_at RBMS1 " RNA binding motif, single stranded interacting protein 1" 1.569 200657_at SLC25A5 " solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5" 1.569 201005_at CD9 CD9 antigen (p24) 1.569 209932_s_at DUT dUTP pyrophosphatase 1.569 212585_at OSBPL8 oxysterol binding protein-like 8 1.569 202710_at BET1 BET1 homolog (S. cerevisiae) 1.569 218044_x_at PTMS parathymosin 1.569 210375_at PTGER3 prostaglandin E receptor 3 (subtype EP3) 1.569 200709_at FKBP1A " FK506 binding protein 1A, 12kDa" 1.569 204369_at PIK3CA " phosphoinositide-3-kinase, catalytic, alpha polypeptide" 1.569 204759_at CHC1L chromosome condensation 1-like 1.569 212887_at SEC23A Sec23 homolog A (S. cerevisiae) 1.569 212108_at ETEA expressed in T-cells and eosinophils in 1.558 204299_at FUSIP1 FUS interacting protein (serine-arginine rich) 1 1.558 217933_s_at LAP3 leucine aminopeptidase 3 1.558 208407_s_at CTNND1 " (cadherin-associated protein), delta 1" 1.558 201769_at ENTH enthoprotin 1.558 212810_s_at SLC1A4 " solute carrier family 1 (glutamate/neutral amino acid transporter), member 4" 1.558 201518_at CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila ) 1.558 208850_s_at THY1 Thy-1 cell surface antigen 1.558 202920_at ANK2 " ankyrin 2, neuronal" 1.558 200751_s_at HNRPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 1.558 200754_x_at SFRS2 " splicing factor, arginine/serine-rich 2" 1.558 201549_x_at PLU-1 putative DNA/chromatin binding motif Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.558 203493_s_at KIAA0092 translokin 1.558 40189_at SET SET translocation (myeloid leukemia-associated) 1.558 208795_s_at MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) 1.558 209233_at C2F C2f protein 1.558 218165_at FLJ11730 FLJ11730 1.558 201263_at TARS threonyl-tRNA synthetase 1.558 218082_s_at UBP1 upstream binding protein 1 (LBP-1a) 1.558 204839_at POP5 RNase MRP/RNase P protein-like 1.558 218163_at MCT-1 MCT-1 protein 1.558 203381_s_at APOE apolipoprotein E 1.558 212367_at FEM1B fem-1 homolog b (C. elegans) 1.558 211284_s_at GRN granulin 1.558 208729_x_at HLA-B " major histocompatibility complex, class I, B" 1.558 201786_s_at ADAR " , RNA- specific" 1.548 217967_s_at C1ORF24 chromosome 1 open reading frame 24 1.548 200046_at DAD1 defender against cell death 1 1.548 217725_x_at PAI-RBP1 PAI-1 mRNA-binding protein 1.548 208152_s_at DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 1.548 202006_at PTPN12 " protein tyrosine phosphatase, non-receptor type 12" 1.548 213496_at HYpothetical HYpothetical protein protein 1.548 201236_s_at BTG2 " BTG family, member 2" 1.548 213001_at ANGPTL2 angiopoietin-like 2 1.548 211297_s_at CDK7 " cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)" 1.548 202596_at ENSA endosulfine alpha 1.548 218898_at CT120 membrane protein expressed in epithelial-like lung adenocarcinoma 1.548 213864_s_at NAP1L1 nucleosome assembly protein 1- like 1 1.548 203972_s_at PEX3 peroxisomal biogenesis factor 3 1.548 202543_s_at GMFB " glia maturation factor, beta" 1.548 206157_at PTX3 " pentaxin-related gene, rapidly induced by IL-1 beta" 1.548 200742_s_at CLN2 " ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease)" 1.548 212824_at FUBP3 far upstream element (FUSE) binding protein 3 1.548 218383_at C14ORF94 chromosome 14 open reading frame 94 1.548 214440_at NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 1.548 202314_at CYP51A1 " cytochrome P450, family 51, subfamily A, polypeptide 1" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.548 218341_at FLJ11838 FLJ11838 1.548 202595_s_at LEPROTL1 leptin receptor overlapping transcript-like 1 1.548 211963_s_at ARPC5 " actin related protein 2/3 complex, subunit 5, 16kDa" 1.548 213761_at MDM1 nuclear protein double minute 1 1.548 205930_at GTF2E1 " general transcription factor IIE, polypeptide 1, alpha 56kDa" 1.548 211423_s_at SC5DL " sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like" 1.548 218358_at MGC11256 MGC11256 1.537 210054_at MGC4701 MGC4701 1.537 204224_s_at GCH1 GTP cyclohydrolase 1 (dopa- responsive dystonia) 1.537 200743_s_at CLN2 " ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease)" 1.537 221773_at ELK3 " ELK3, ETS-domain protein (SRF accessory protein 2)" 1.537 200814_at PSME1 " proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)" 1.537 207602_at HAT airway -like protease 1.537 210145_at PLA2G4A " A2, group IVA (cytosolic, calcium-dependent)" 1.537 41660_at CELSR1 " cadherin, EGF LAG seven-pass G-type receptor 1 ( homolog, Drosophila)" 1.537 201947_s_at CCT2 " chaperonin containing TCP1, subunit 2 (beta)" 1.537 209301_at CA2 carbonic anhydrase II 1.537 201955_at CCNC cyclin C 1.537 203401_at PRPS2 phosphoribosyl pyrophosphate synthetase 2 1.537 211716_x_at ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 1.537 206912_at FOXE1 forkhead box E1 (thyroid transcription factor 2) 1.537 209157_at DNAJA2 " DnaJ (Hsp40) homolog, subfamily A, member 2" 1.537 204368_at SLC21A2 " solute carrier family 21 (prostaglandin transporter), member 2" 1.537 212857_x_at PC4 (RNA pol activated RNA polymerase II II cofactor 4) transcription cofactor 4 1.537 219756_s_at POF1B premature ovarian failure 1B 1.537 201011_at RPN1 ribophorin I 1.537 208739_x_at SMT3H2 SMT3 suppressor of mif two 3 homolog 2 (yeast) 1.537 212429_s_at GTF3C2 " general transcription factor IIIC, polypeptide 2, beta 110kDa" 1.537 214459_x_at HLA-C " major histocompatibility complex, class I, C" 1.537 200047_s_at YY1 YY1 transcription factor Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.537 213682_at NUP50 nucleoporin 50kDa 1.526 210136_at MBP myelin basic protein 1.526 218807_at VAV3 vav 3 oncogene 1.526 211528_x_at HLA-A " major histocompatibility complex, class I, A" 1.526 209291_at ID4 " inhibitor of DNA binding 4, dominant negative helix-loop- helix protein" 1.526 211980_at COL4A1 " collagen, type IV, alpha 1" 1.526 202935_s_at SOX9 " SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)" 1.526 200631_s_at SET SET translocation (myeloid leukemia-associated) 1.526 212091_s_at COL6A1 " collagen, type VI, alpha 1" 1.526 220890_s_at DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 1.526 202680_at GTF2E2 " general transcription factor IIE, polypeptide 2, beta 34kDa" 1.526 212652_s_at SNX4 sorting nexin 4 1.526 201343_at UBE2D2 " ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)" 1.526 202068_s_at LDLR low density lipoprotein receptor (familial hypercholesterolemia) 1.526 209203_s_at RPL30 ribosomal protein L30 1.526 222303_at ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 1.526 203823_at RGS3 regulator of G-protein signalling 3 1.526 201980_s_at RSU1 Ras suppressor protein 1 1.526 219038_at FLJ11565 FLJ11565 1.526 202600_s_at NRIP1 nuclear receptor interacting protein 1 1.526 221529_s_at PLVAP plasmalemma vesicle associated protein 1.526 205514_at ZNF415 zinc finger protein 415 1.526 209587_at PITX1 paired-like homeodomain transcription factor 1 1.526 212037_at PNN " pinin, desmosome associated protein" 1.526 212296_at PSMD14 " proteasome (prosome, macropain) 26S subunit, non- ATPase, 14" 1.526 217752_s_at CN2 cytosolic nonspecific dipeptidase (EC 3.4.13.18) 1.526 201970_s_at NASP nuclear autoantigenic sperm protein (histone-binding) 1.526 36936_at TSTA3 tissue specific transplantation antigen P35B 1.526 211666_x_at RPL3 ribosomal protein L3 1.526 204298_s_at LOX lysyl oxidase 1.516 53071_s_at FLJ22222 FLJ22222 1.516 37462_i_at SF3A2 " splicing factor 3a, subunit 2, 66kDa" 1.516 205011_at LOH11CR2A " loss of heterozygosity, 11, chromosomal region 2, gene A" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.516 202735_at EBP emopamil binding protein (sterol isomerase) 1.516 201225_s_at SRRM1 serine/arginine repetitive matrix 1 1.516 208895_s_at DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 1.516 205016_at TGFA " transforming growth factor, alpha" 1.516 200037_s_at CBX3 " chromobox homolog 3 (HP1 gamma homolog, Drosophila)" 1.516 210505_at ADH7 " alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide" 1.516 216041_x_at GRN granulin 1.516 217732_s_at ITM2B integral membrane protein 2B 1.516 208988_at FBXL11 F-box and leucine-rich repeat protein 11 1.516 203956_at KIAA0852 KIAA0852 protein 1.516 212594_at HYpothetical HYpothetical protein protein 1.516 216977_x_at SNRPA1 small nuclear ribonucleoprotein polypeptide A' 1.516 201301_s_at ANXA4 annexin A4 1.516 221691_x_at NPM1 " nucleophosmin (nucleolar phosphoprotein B23, numatrin)" 1.516 221269_s_at SH3BGRL3 SH3 domain binding -rich protein like 3 1.516 209067_s_at HNRPDL heterogeneous nuclear ribonucleoprotein D-like 1.516 221916_at NEFL " neurofilament, light polypeptide 68kDa" 1.516 201210_at DDX3X " DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked" 1.505 222108_at AMIGO2 amphoterin induced gene 2 1.505 206710_s_at EPB41L3 erythrocyte membrane protein band 4.1-like 3 1.505 211989_at SMARCE1 " SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1" 1.505 200807_s_at HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.505 201019_s_at EIF1A eukaryotic translation initiation factor 1A 1.505 208959_s_at TXNDC4 thioredoxin domain containing 4 (endoplasmic reticulum) 1.505 201096_s_at ARF4 ADP-ribosylation factor 4 1.505 200678_x_at GRN granulin 1.505 204366_s_at GTF3C2 " general transcription factor IIIC, polypeptide 2, beta 110kDa" 1.505 201558_at RAE1 RAE1 RNA export 1 homolog (S. pombe) 1.505 219134_at ELTD1 " EGF, and seven transmembrane domain containing 1" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

1.505 211623_s_at FBL fibrillarin 1.505 218556_at ORMDL2 ORM1-like 2 (S. cerevisiae) 1.505 213346_at LOC93081 BC015148 1.505 219777_at HIAN2 immune associated nucleotide 2 1.505 217954_s_at PHF3 PHD finger protein 3 1.505 212639_x_at K-ALPHA-1 "tubulin, alpha, ubiquitous" 1.505 208836_at ATP1B3 " ATPase, Na+/K+ transporting, beta 3 polypeptide" 1.505 204682_at LTBP2 latent transforming growth factor beta binding protein 2 1.505 210946_at PPAP2A phosphatidic acid phosphatase type 2A 1.505 200055_at TAF10 " TAF10 RNA polymerase II, TATA box binding protein (TBP)- associated factor, 30kDa" 1.505 205990_s_at WNT5A " wingless-type MMTV integration site family, member 5A" 1.505 201303_at DDX48 DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 1.505 200800_s_at HSPA1A heat shock 70kDa protein 1A -2.143 209555_s_at CD36 " CD36 antigen (collagen type I receptor, thrombospondin receptor)" -9.063 205177_at TNNI1 " I, skeletal, slow" -8.514 206844_at FBP2 " fructose-1,6-bisphosphatase 2" -6.821 206204_at GRB14 growth factor receptor-bound protein 14 -6.634 203861_s_at ACTN2 " actinin, alpha 2" -6.021 205766_at TCAP -cap (telethonin) -5.775 205951_at MYH1 " myosin, heavy polypeptide 1, skeletal muscle, adult" -5.617 205736_at PGAM2 phosphoglycerate mutase 2 (muscle) -5.617 214475_x_at CAPN3 " 3, (p94)" -5.502 207302_at SGCG " sarcoglycan, gamma (35kDa -associated glycoprotein)" -5.13 219829_at ITGB1BP2 binding protein (melusin) 2 -5.028 206895_at PPP1R3A " protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle)" -4.287 207148_x_at MYOZ2 myozenin 2 -4.287 213201_s_at TNNT1 " troponin T1, skeletal, slow" -4.112 208148_at MYH4 " myosin, heavy polypeptide 4, skeletal muscle" -4.055 210305_at PDE4DIP 4D interacting protein (myomegalin) -4.027 205553_s_at CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -3.863 203863_at ACTN2 " actinin, alpha 2" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

-3.837 206372_at MYF6 myogenic factor 6 (herculin) -3.732 34471_at MYH8 " myosin, heavy polypeptide 8, skeletal muscle, perinatal" -3.655 222287_at TRDN triadin -3.655 205388_at TNNC2 " troponin C2, fast" -3.458 207066_at HRC rich calcium binding protein -3.340 206160_at APOBEC2 " apolipoprotein B mRNA editing enzyme, catalytic polypeptide- like 2" -3.340 204483_at ENO3 " enolase 3, (beta, muscle)" -3.317 205354_at GAMT guanidinoacetate N- methyltransferase -3.317 205589_at MYL3 " myosin, light polypeptide 3, alkali; ventricular, skeletal, slow" -3.271 217623_at HYpothetical HYpothetical protein protein -3.271 214468_at MYH6 " myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)" -3.249 219645_at CASQ1 " 1 (fast-twitch, skeletal muscle)" -3.204 205295_at CKMT2 " , mitochondrial 2 (sarcomeric)" -3.1821 205054_at NEB nebulin -3.1821 202222_s_at DES -3.031433133 213684_s_at HYpothetical HYpothetical protein protein -3.010493495 206375_s_at HSPB3 heat shock 27kDa protein 3 -2.989698497 206394_at MYBPC2 " myosin binding , fast type" -2.948538435 205163_at HUMMLC2B 2 -2.948538435 206393_at TNNI2 " , skeletal, fast" -2.928171392 214590_s_at UBE2D1 " ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)" -2.907945035 208204_s_at CAV3 caveolin 3 -2.867910496 209700_x_at PDE4DIP phosphodiesterase 4D interacting protein (myomegalin) -2.867910496 214365_at TPM3 3 -2.828427125 204737_s_at MYH7 " myosin, heavy polypeptide 7, cardiac muscle, beta" -2.808889751 202825_at SLC25A4 " solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4" -2.770218936 221994_at HYpothetical HYpothetical protein protein -2.732080514 214087_s_at MYBPC1 " myosin binding protein C, slow type" -2.713208655 213782_s_at MYOZ2 myozenin 2 -2.694467154 205693_at TNNT3 " troponin T3, skeletal, fast" -2.657371628 209742_s_at MYL2 " myosin, light polypeptide 2, regulatory, cardiac, slow" -2.639015822 206768_at RPL3L ribosomal protein L3-like Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

-2.620786808 204810_s_at CKM " creatine kinase, muscle" -2.602683711 205741_s_at DTNA " dystrobrevin, alpha" -2.584705661 206717_at MYH8 " myosin, heavy polypeptide 8, skeletal muscle, perinatal" -2.566851795 216265_x_at MYH7 " myosin, heavy polypeptide 7, cardiac muscle, beta" -2.566851795 207089_at NRAP nebulin-related anchoring protein -2.566851795 206117_at TPM1 tropomyosin 1 (alpha) -2.549121255 219509_at MYOZ1 myozenin 1 -2.531513188 206121_at AMPD1 adenosine monophosphate deaminase 1 (isoform M) -2.514026749 205132_at ACTC " actin, alpha, cardiac muscle" -2.514026749 204938_s_at PLN -2.496661098 217515_s_at CACNA1S " calcium channel, voltage- dependent, L type, alpha 1S subunit" -2.462288827 214027_x_at DES desmin -2.462288827 213371_at LDB3 LIM domain binding 3 -2.37841423 206116_s_at TPM1 tropomyosin 1 (alpha) -2.361985323 218934_s_at HSPB7 " heat shock 27kDa , member 7 (cardiovascular)" -2.345669898 205374_at SLN sarcolipin -2.313376368 203862_s_at ACTN2 " actinin, alpha 2" -2.281527432 206996_x_at CACNB1 " calcium channel, voltage- dependent, beta 1 subunit" -2.281527432 205577_at PYGM " phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V)" -2.281527432 209904_at TNNC1 " , slow" -2.250116969 204631_at MYH2 " myosin, heavy polypeptide 2, skeletal muscle, adult" -2.173469725 203295_s_at ATP1A2 " ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide" -2.173469725 204979_s_at SH3BGR SH3 domain binding glutamic acid-rich protein -2.143546925 212390_at PDE4DIP phosphodiesterase 4D interacting protein (myomegalin) -2.128740365 206353_at COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 -2.128740365 208195_at TTN titin -2.128740365 212730_at DMN desmuslin -2.114036081 205610_at MYOM1 myomesin 1 (skelemin) 185kDa -2.070529848 207876_s_at FLNC " filamin C, gamma (actin binding protein 280)" -2.070529848 204939_s_at PLN phospholamban -2.070529848 204173_at MLC1SA myosin light chain 1 slow a -2.0139111 218168_s_at CABC1 " , ABC1 activity of bc1 complex like (S. pombe)" -1.986184991 219926_at POPDC3 popeye domain containing 3 -1.986184991 204570_at COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -1.972465409 204083_s_at TPM2 tropomyosin 2 (beta) -1.972465409 210944_s_at CAPN3 " calpain 3, (p94)" Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

-1.972465409 204940_at PLN phospholamban -1.958840595 219804_at FLJ12921 FLJ12921 -1.945309895 210976_s_at PFKM " phosphofructokinase, muscle" -1.945309895 209283_at CRYAB " , alpha B" -1.931872658 203864_s_at ACTN2 " actinin, alpha 2" -1.931872658 213717_at LDB3 LIM domain binding 3 -1.931872658 212554_at CAP2 " CAP, adenylate cyclase- associated protein, 2 (yeast)" -1.931872658 203296_s_at ATP1A2 " ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide" -1.918528239 202587_s_at AK1 adenylate kinase 1 -1.905275996 213955_at MYOZ3 myozenin 3 -1.905275996 201539_s_at FHL1 four and a half LIM domains 1 -1.892115293 205872_x_at PDE4DIP phosphodiesterase 4D interacting protein (myomegalin) -1.892115293 212361_s_at ATP2A2 " ATPase, Ca++ transporting, cardiac muscle, slow twitch 2" -1.866065983 206488_s_at CD36 " CD36 antigen (collagen type I receptor, thrombospondin receptor)" -1.853176124 210201_x_at BIN1 bridging integrator 1 -1.840375301 212654_at TPM2 tropomyosin 2 (beta) -1.8276629 208353_x_at ANK1 " ankyrin 1, erythrocytic" -1.8276629 219949_at LRRC2 leucine-rich repeat-containing 2 -1.815038311 205478_at PPP1R1A " protein phosphatase 1, regulatory (inhibitor) subunit 1A" -1.815038311 213317_at HYpothetical HYpothetical protein protein -1.802500925 205030_at FABP7 " fatty acid binding protein 7, brain" -1.790050142 219772_s_at SMPX " small muscle protein, X- linked" -1.753211443 212551_at CAP2 " CAP, adenylate cyclase- associated protein, 2 (yeast)" -1.717130873 205356_at USP13 ubiquitin specific protease 13 (isopeptidase T-3) -1.717130873 210069_at CPT1B carnitine palmitoyltransferase 1B (muscle) -1.717130873 209888_s_at MYL1 " myosin, light polypeptide 1, alkali; skeletal, fast" -1.693490625 219144_at MGC1136 MGC1136 -1.681792831 214285_at FABP3 " fatty acid binding protein 3, muscle and heart (mammary- derived growth inhibitor)" -1.658639092 218963_s_at KRT23 keratin 23 (histone deacetylase inducible) -1.658639092 205824_at HSPB2 heat shock 27kDa protein 2 -1.647182035 216887_s_at LDB3 LIM domain binding 3 -1.635804117 203661_s_at TMOD1 1 -1.635804117 202931_x_at BIN1 bridging integrator 1 -1.624504793 210170_at ALP alpha-actinin-2-associated LIM protein -1.624504793 219728_at TTID titin immunoglobulin domain protein (myotilin) Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

-1.613283518 210298_x_at FHL1 four and a half LIM domains 1 -1.613283518 203872_at ACTA1 " actin, alpha 1, skeletal muscle" -1.580082624 213547_at TIP120B TBP-interacting protein -1.580082624 204284_at PPP1R3C " protein phosphatase 1, regulatory (inhibitor) subunit 3C" -1.569168196 210299_s_at FHL1 four and a half LIM domains 1 -1.558329159 218510_x_at FLJ20152 FLJ20152 -1.547564994 207317_s_at CASQ2 calsequestrin 2 (cardiac muscle) -1.547564994 219963_at DUSP13 dual specificity phosphatase 13 -1.547564994 214769_at CLCN4 chloride channel 4 -1.547564994 209632_at PPP2R3A " (formerly 2A), regulatory subunit B'', alpha" -1.536875181 218025_s_at PECI " peroxisomal D3,D2-enoyl-CoA isomerase" -1.536875181 221276_s_at protein syncoilin -1.536875181 204179_at MB myoglobin -1.505246747 210202_s_at BIN1 bridging integrator 1 -1.505246747 214439_x_at BIN1 bridging integrator 1 -5.13370359 211476_at MYOZ2 myozenin 2 -4.28709385 205391_x_at ANK1 " ankyrin 1, erythrocytic" -3.410539567 214099_s_at PDE4DIP phosphodiesterase 4D interacting protein (myomegalin) -3.340351678 220855_at CLTC " clathrin, heavy polypeptide (Hc)" -2.789487333 208352_x_at ANK1 " ankyrin 1, erythrocytic" -2.694467154 207284_s_at ASPH aspartate beta-hydroxylase -2.67585511 205444_at ATP2A1 " ATPase, Ca++ transporting, cardiac muscle, fast twitch 1" -2.584705661 216859_x_at HYpothetical HYpothetical protein protein -2.549121255 207981_s_at ESRRG estrogen-related receptor gamma -2.445280555 219525_at FLJ10847 FLJ10847 -2.394957409 204217_s_at RTN2 reticulon 2 -2.37841423 214121_x_at ENIGMA enigma (LIM domain protein) -2.361985323 205749_at CYP1A1 " cytochrome P450, family 1, subfamily A, polypeptide 1" -2.250116969 210967_x_at CACNB1 " calcium channel, voltage- dependent, beta 1 subunit" -2.219138944 211751_at PDE4DIP phosphodiesterase 4D interacting protein (myomegalin) -2.188587403 203608_at ALDH5A1 " aldehyde dehydrogenase 5 family, member A1 (succinate- semialdehyde dehydrogenase)" -2.128740365 205738_s_at FABP3 " fatty acid binding protein 3, muscle and heart (mammary- derived growth inhibitor)" -2.056227653 206254_at EGF epidermal growth factor (beta- urogastrone) Table: Significant gene list. From Banerjee AG et al, 2005. Molecular Cancer Therapeutics –05-0033

-1.958840595 207063_at HYpothetical HYpothetical protein protein -1.958840595 204351_at S100P S100 calcium binding protein P -1.802500925 205389_s_at ANK1 " ankyrin 1, erythrocytic" -1.802500925 206177_s_at ARG1 " , liver" -1.802500925 216459_x_at HYpothetical HYpothetical protein protein -1.753211443 221217_s_at A2BP1 ataxin 2-binding protein 1 -1.753211443 213693_s_at MUC1 " mucin 1, transmembrane" -1.729074463 207087_x_at ANK1 " ankyrin 1, erythrocytic" -1.705269784 206834_at HBD " hemoglobin, delta" -1.681792831 206835_at STATH statherin -1.681792831 205485_at RYR1 1 (skeletal) -1.681792831 211712_s_at ANXA9 annexin A9 -1.670175839 212531_at LCN2 lipocalin 2 (oncogene 24p3) -1.647182035 216331_at ITGA7 " integrin, alpha 7" -1.624504793 207110_at KCNJ12 " potassium inwardly-rectifying channel, subfamily J, member 12" -1.613283518 208813_at GOT1 " glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)" -1.613283518 204612_at PKIA " protein kinase (cAMP- dependent, catalytic) inhibitor alpha" -1.602139755 206404_at FGF9 fibroblast growth factor 9 (glia-activating factor) -1.591072968 202104_s_at SPG7 " spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive)" -1.547564994 214235_at CYP3A5 " cytochrome P450, family 3, subfamily A, polypeptide 5" -1.547564994 210632_s_at SGCA " sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)" -1.547564994 213706_at GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) -1.536875181 207016_s_at ALDH1A2 " aldehyde dehydrogenase 1 family, member A2" -1.526259209 204712_at WIF1 WNT inhibitory factor 1 -1.526259209 203720_s_at ERCC1 " excision repair cross- complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)" -1.515716567 215281_x_at POGZ pogo transposable element with ZNF domain -1.505246747 221612_at HT017 HT017 protein -1.505246747 216109_at KIAA1025 KIAA1025 protein -1.505246747 205044_at GABRP " gamma-aminobutyric acid (GABA) A receptor, pi"