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Synergistic Effect of the Herbal Mixture C5E on Gemcitabine Treatment in PANC‑1 Cells
MOLECULAR MEDICINE REPORTS 23: 315, 2021 Synergistic effect of the herbal mixture C5E on gemcitabine treatment in PANC‑1 cells PYO JUNE PAK1*, DONG GUN LEE1*, JI HYUN SUNG2, SEUNG HYUN JUNG3, TAE‑YOUNG HAN4, SUNG HYO PARK1 and NAMHYUN CHUNG1 1Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841; 2Flow Cytometry Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul 03082; 3School of Oriental Medicine, Dongguk University, Ilsan 10326; 4BanryongInsu Herb Clinic, Seoul 06099, Republic of Korea Received April 1, 2020; Accepted September 28, 2020 DOI: 10.3892/mmr.2021.11954 Abstract. The present study aimed to determine the anticancer the treatment with either C5E or gemcitabine alone. As the effect of the herbal mixture extract C5E in the pancreatic cancer co‑treatment with gemcitabine and C5E was more effective cell line, PANC‑1, in the absence or presence of gemcitabine than each individual treatment, the present study suggested treatment, a chemotherapeutic drug used for the treatment of that the combined treatment may exhibit synergistic effects in pancreatic cancer. The anticancer effects of C5E, gemcitabine PANC‑1 cells. and C5E plus gemcitabine in PANC‑1 cells following 72 h of treatment were investigated. The effect of each treatment on Introduction cell cycle arrest, apoptosis and the proportion of side popula‑ tion (SP) cells was determined using flow cytometric analysis Pancreatic cancer is a fatal disease, representing the fourth following propidium iodide (PI), Annexin V‑FITC/PI double leading cause of cancer‑related deaths worldwide. Only a few staining and Hoechst 33342 staining, respectively. -
Supplementary Materials 1
Supplementary materials 1 Table S1 The characteristics of botanical preparations potentially containing alkenylbenzenes on the Chinese market. Botanical Pin Yin Name Form Ingredients Recommendation for daily intake (g) preparations (汉语) Plant food supplements (PFS) Si Ji Kang Mei Yang Xin Yuan -Rou Dou Kou xylooligosaccharide, isomalt, nutmeg (myristica PFS 1 Fu He Tang Pian tablet 4 tablets (1.4 g) fragrans), galangal, cinnamon, chicken gizzards (四季康美养心源-肉豆蔻复合糖片) Ai Si Meng Hui Xiang fennel seed, figs, prunes, dates, apples, St.Johns 2-4 tablets (2.8-5.6 g) PFS 2 Fu He Pian tablet Breed, jamaican ginger root (爱司盟茴香复合片) Zi Ran Mei Xiao Hui Xiaong Jiao Nang foeniculi powder, cinnamomi cortex, papaya PFS 3 capsule concentrated powder, green oat concentrated powder, 3 capsules (1.8 g) (自然美小茴香胶囊) brewer’s yeast, cabbage, monkey head mushroom An Mei Qi Hui Xiang Cao Ben Fu He Pian fennel seed, perilla seed, cassia seed, herbaceous PFS 4 tablet 1-2 tablets (1.4-2.8 g) (安美奇茴香草本复合片) complex papaya enzymes, bromelain enzymes, lactobacillus An Mei Qi Jiao Su Xian Wei Ying Yang Pian acidophilus, apple fiber, lemon plup fiber, fennel PFS 5 tablet seed, cascara sagrada, jamaican ginger root, herbal 2 tablets (2.7 g) (安美奇酵素纤维营养片) support complex (figs, prunes, dates, apples, St. Johns bread) Table S1 (continued) The characteristics of botanical preparations potentially containing alkenylbenzenes on the Chinese market. Pin Yin Name Botanical Form Ingredients Recommendation for daily intake (g) preparations (汉语) Gan Cao Pian glycyrrhiza uralensis, licorice -
Herbal Recipes for Preventing and Addressing Upper Respiratory
1 Herbal Recipes for Preventing and Addressing Upper Respiratory Infections by Rosalee de la Forêt 2 Text by Rosalee de la Forêt. Illustrations by Tatiana Rusakova ©2020 Rosalee de la Forêt, LLC. All rights reserved. No part of this publication may be reproduced in whole or in part, or stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without written permission of the author. The herbal and plant information in this ebook is for educational purposes only. The information within the ebook is not intended as a substitute for the advice provided by your physician or other medical professional. If you have or suspect that you have a serious health problem, promptly contact your health care provider. Always consult with a health care practitioner before using any herbal remedy or food, especially if pregnant, nursing, or have a medical condition. Published by Rosalee de la Forȇt, LLC, Methow Valley, WA First digital edition, March 2020. Published in the U.S.A 3 Astragalus Immune-Building Chai 4 Strong Elderberry Tea 5 Parsley & Garlic Gremolata 6 Garlic-Infused Honey 7 Kid’s Immune Support Tea 8 Elderflower and Yarrow Tea 9 Strong Chamomile Tea 10 Cayenne Tea 11 Healthy Lungs Tea 12 Looking for herbs? 13 About Rosalee 14 4 Astragalus Immune-Building Chai I drink a version of this throughout the winter months and attribute it to my good health. It’s spicy, sweet, delicious and is best when taken daily for an extended period of time. Ingredients 30 grams dried Astragalus root (A. -
Supplementstop for Immune Support
SUPPLEMENTSTOP FOR IMMUNE SUPPORT Three Generation’s of Truth in Nutrition Table of Contents 3 1 Maintaining healthy immune function 6 2 Sleep and mental health 9 3 The one-two punch for pain, inflammation 11 4 Four ways to provide a virus-season boost and maintaining a healthy gut microbiota 13 5 Essential vitamins and minerals for overall good health 2 1 Maintaining healthy immune function Poor immune systems causing record work losses According to a new study published in the September 2019 issue of the Journal of Occupational and Environmental Medicine, nearly one-fifth of working adults will experience a cold each year. The study estimated 20 million annual missed workdays might be just the tip of the iceberg, because the estimates include only colds that resulted in doctor’s visits or restricted activity days. There may be as many as 70 million lost workdays due to colds, when actual missed work time is combined with lost productivity. Past flu seasons likely cost employers nationwide millions of lost workdays and billions of dollars. Nearly 111 million workdays are lost due to the flu each year, There may be as many as according to Flu.gov, costing employers approximately $7 billion per year in sick days and lost productivity. 70 million lost workdays The study also found Americans spend nearly $3 billion annually on over- due to colds, when the-counter drugs that may not provide any symptom relief. actual missed work time Since the 1940s, studies have shown the use of botanicals and nutritional supplements may both prevent and reduce the effects of common colds and is combined with lost influenza and support immune cell function and promote respiratory health.* productivity. -
Traditional Chinese Medicine Ingredients (Tcmi)
NATURAL HEALTH PRODUCT TRADITIONAL CHINESE MEDICINE INGREDIENTS (TCMI) This monograph is intended to serve as a guide to industry for the preparation of Product Licence Applications (PLAs) and labels for natural health product market authorization. It is not intended to be a comprehensive review of the medicinal ingredient. Notes By submitting a PLA referencing this monograph, the applicant is attesting that the product will comply fully with the recommended conditions of use outlined in this monograph, including, the conditions found in the Traditional Chinese Medicine (TCM) referenced texts (those provided in the reference section below). The conditions of use include methods of preparations, source materials, doses, durations of use, combinations of medicinal ingredients, risk statements, and the theory of TCM. Text in parentheses is additional optional information which can be included on the PLA and product label at the applicant’s discretion. The solidus (/) indicates that the terms and/or the statements are synonymous. Either term or statement may be selected by the applicant. Date June 9, 2015 Medicinal Ingredients Refer to Tables 1 and 2 in Appendix I for lists of acceptable medicinal ingredients. Refer to Table 3 in Appendix I for medicinal ingredients that are only allowable when prepared according to the specifications outlined in the Natural Health Product Ingredients Database (NHPID). Refer to Table 4 in Appendix I for medicinal ingredients excluded from this monograph. Proper name(s) and Common name(s) Refer to Appendix I for lists of acceptable proper name(s) and common name(s). Source material(s) As specified by referenced texts. Brand name(s) Traditional Chinese Medicine Ingredients − Page 1 of 23 The brand name(s) must not be false or misleading or imply any specific use or purpose. -
Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus
International Journal of Molecular Sciences Review Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus Bahare Salehi 1,2 ID , Nanjangud V. Anil Kumar 3 ID , Bilge ¸Sener 4, Mehdi Sharifi-Rad 5,*, Mehtap Kılıç 4, Gail B. Mahady 6, Sanja Vlaisavljevic 7, Marcello Iriti 8,* ID , Farzad Kobarfard 9,10, William N. Setzer 11,*, Seyed Abdulmajid Ayatollahi 9,12,13, Athar Ata 13 and Javad Sharifi-Rad 9,13,* ID 1 Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, 88777539 Tehran, Iran; [email protected] 2 Student Research Committee, Shahid Beheshti University of Medical Sciences, 22439789 Tehran, Iran 3 Department of Chemistry, Manipal Institute of Technology, Manipal University, Manipal 576104, India; [email protected] 4 Department of Pharmacognosy, Gazi University, Faculty of Pharmacy, 06330 Ankara, Turkey; [email protected] (B.¸S.);[email protected] (M.K.) 5 Department of Medical Parasitology, Zabol University of Medical Sciences, 61663-335 Zabol, Iran 6 PAHO/WHO Collaborating Centre for Traditional Medicine, College of Pharmacy, University of Illinois, 833 S. Wood St., Chicago, IL 60612, USA; [email protected] 7 Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia; [email protected] 8 Department of Agricultural and Environmental Sciences, Milan State University, 20133 Milan, Italy 9 Phytochemistry Research Center, Shahid Beheshti University of -
The Use of Chinese Yang/ Qi-Invigorating Tonic Botanical Drugs/ Herbal Formulations in Ameliorating Chronic Kidney Disease by Enhancing Mitochondrial Function
REVIEW published: 24 June 2021 doi: 10.3389/fphar.2021.622498 The Use of Chinese Yang/ Qi-Invigorating Tonic Botanical Drugs/ Herbal Formulations in Ameliorating Chronic Kidney Disease by Enhancing Mitochondrial Function Jiayi Tian 1,2†, Yuqi Huang 1,2†, Tong Wu 1,2, Hsien-Da Huang 2,3, Kam Ming Ko 4*, Bao Ting Zhu 1,2* and Jihang Chen 1,2* 1Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, China, 2School of Life and Health Sciences, The Chinese University of Hong Kong, Edited by: Shenzhen, China, 3Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, China, 4Division Uraiwan Panich, of Life Science, The Hong Kong University of Science & Technology, Hong Kong, China Mahidol University, Thailand Reviewed by: Mingjiang Yao, Background: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality. Xiyuan Hospital, China Mitochondrial dysfunction has been implicated as a key factor in the development of CKD. Rodrigo Castaneda, According to traditional Chinese medicine (TCM) theory, many Chinese Yang/Qi- Universidad de San Carlos de Guatemala, Guatemala invigorating botanical drugs/herbal formulations have been shown to produce *Correspondence: promising outcomes in the clinical management of CKD. Experimental studies have Jihang Chen indicated that the health-promoting action of Yang/Qi invigoration in TCM is related to [email protected] Bao Ting Zhu the up-regulation of mitochondrial energy generation and antioxidant status. [email protected] Kam Ming Ko Objective: In this review, we aim to test whether Chinese Yang/Qi-invigorating tonic [email protected] botanical drugs/herbal formulations can provide medical benefits in CKD and its †These authors have contributed complications. -
Identification of Herbal Categories Active in Pain Disorder Subtypes By
The University of Manchester Research Identification of herbal categories active in pain disorder subtypes by machine learning help reveal novel molecular mechanisms of algesia DOI: 10.1016/j.phrs.2020.104797 Document Version Accepted author manuscript Link to publication record in Manchester Research Explorer Citation for published version (APA): Nenadic, G. (2020). Identification of herbal categories active in pain disorder subtypes by machine learning help reveal novel molecular mechanisms of algesia. Pharmacological Research, [104797]. https://doi.org/10.1016/j.phrs.2020.104797 Published in: Pharmacological Research Citing this paper Please note that where the full-text provided on Manchester Research Explorer is the Author Accepted Manuscript or Proof version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version. General rights Copyright and moral rights for the publications made accessible in the Research Explorer are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Takedown policy If you believe that this document breaches copyright please refer to the University of Manchester’s Takedown Procedures [http://man.ac.uk/04Y6Bo] or contact [email protected] providing relevant details, so we can investigate your claim. Download date:11. Oct. 2021 Journal Pre-proof Identification of herbal categories -
An Important Mechanism of Herb-Induced Hepatotoxicity: to Produce Rms Based on Active Functional Groups-Containing Ingredients from Phytomedicine by Binding Cyp450s
Chinese Herbal Medicines 11 (2019) 239–257 Contents lists available at ScienceDirect Chinese Herbal Medicines journal homepage: www.elsevier.com/locate/chmed Review An important mechanism of herb-induced hepatotoxicity: To produce RMs based on active functional groups-containing ingredients from phytomedicine by binding CYP450s ∗ Xin He a,b, , Zi-jun Wu a, Li-li Wang a, Xue Gao a,b, Yue Hai a, Wen-li Liu a, Le-mei Du a, Lei Zhang a, Ai-hong Yang a, Nan-nan Huang a a School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China b School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510 0 06, China a r t i c l e i n f o a b s t r a c t Article history: Reactive metabolites (RMs) generated by hepatic metabolism are thought to play an important role in the Received 22 December 2018 pathogenesis of drug-induced liver injury (DILI). Like many synthetic drugs undergoing metabolic activa- Revised 15 March 2019 tion to form RMs which are often associated with drug toxicity, it is recognized that some herbal compo- Accepted 18 April 2019 nents may be also converted to toxic, or even mutagenetic and carcinogenic metabolites by cytochrome Available online 9 July 2019 P450s (CYP450s). This review focuses on the metabolic activation of herbal components and its liver Keywords: toxicological implications. By summarizing references, we found that hepatotoxic herbal components via active functional groups producing RMs have some certain structural dependence. There is a correlation -
HERB GARDEN PLANT LIST – 2020 NO. Botanical Name Common
HERB GARDEN PLANT LIST – 2020 NO. Botanical Name Common Name Parts used Use 100 Achillea millefolium ……………………........………......(Yarrow) N ………………………......…......All parts …………….........Astringent 101 Aquilegia vulgaris………………………......…...............(Columbine) N ........…………...….............. All parts………..………....Astringent & Analgesic 102 Buddleia alternafolia....…………...…………...........…..(Fountain Butterfly Bush)………………..................................................Attracts Beneficial Insects 103 Primula vulgaris....………………...………...……..........(Primrose)………………………...…...........All parts………...………...Antispasmodic 104 Tanacetum vulgaris……………...……….............…..….(Tansy)……………….......………..…....…..Leaves & Flowers...............Insect Repellent 105 Aconitum vulgaris...……………...………………............(Monkshood)…………………......…….......All Parts Unsafe.........…....Ornamental 106 Pulmonaria longifolia..........……………...…...…..........(Lungwort)…………………......……….......Leaves.....…………...….....Lung Ailments 107 Dicentra spectabilis…….….…….…….…....…....…..….(Bleeding Heart)....……......…………………………….....…………….Ornamental 108 Actea racemose..…………….……………...…...........….(Black Cohosh)…….………...….............….Roots......…...…….………Menopausal Symptoms 109 Hydrastis Canadensis..............………......………..........(Golden Seal) N....………….......…..……….Roots………….…………..Antibiotic & Anti-inflammatory 110 Inula helenium......................…………………………….(Elecampane) .....…..........………………….Roots……………………..Immune System & Antibacteria 111 Alchemilla mollis....................…………………...………(Lady’s -
Research Article
T.O. Lawal. et al. Medical Research Archives vol 6, issue 1, January 2018 issue Page 1 of 22 RESEARCH ARTICLE NATURAL PRODUCTS AND TRADITIONAL MEDICINES FOR THE TREATMENT OF MULTIDRUG RESISTANT BACTERIA Authors T.O. Lawal1,2, N. Raut2,3, SM Wicks4, G.B. Mahady2 Affiliations: 1Department of Pharmaceutical Microbiology, * Correspondence author: University of Ibadan, Ibadan, Nigeria Gail B. Mahady, Ph.D. 2Department of Pharmacy Practice, College of Department of Pharmacy Practice Pharmacy, PAHO/WHO Collaborating Centre College of Pharmacy, University of Illinois at for Traditional Medicine, University of Illinois Chicago at Chicago, Chicago, IL, USA, 60612. PAHO/WHO Collaborating Centre for 3Department of Pharmaceutical Sciences, Traditional Medicine Rashtrasant Tukadoji Maharj Nagpur 833 S. Wood St, MC 877 University Nagpur-440033 India. Chicago, IL 60612, U.S.A. 4Department of Cellular and Molecular Phone (312) 996-1669 Medicine, Rush University, Chicago, IL, USA Fax (312) 413-5894 60612. Email: [email protected];[email protected] Abstract: Multidrug resistant microorganisms (MDROs) have been responsible for numerous outbreaks of infectious epidemics, and pose a serious threat to global health. The lack of effective therapies for MDROs, coupled with a reduced number of antimicrobial drugs in the pharmaceutical pipeline to treat these infections, demonstrates the urgent need for research in this area. Of the resistant Gram-positive bacteria, methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Pseudomonas aeruginosa and multidrug-resistant tuberculosis (MDR-TB) continue to be the most problematic, however, reports of vancomycin-resistant Staphylococcus aureus (VRSA) infections are also increasing. For highly-resistant Gram-negative bacteria, vancomycin-resistant Enterococci (VRE), multidrug-resistant (MDR) carbapenemase-producing Klebsiella pneumoniae and MDR-Acinetobacter baumannii are most important, as these bacteria are often only susceptible to older antimicrobial agents, such as the polymyxins that have a higher adverse event profile. -
Herbal Advancements in the Treatment to Accelerate Wound Healing
ISSN 2226-3063 e-ISSN 2227-9555 Modern Phytomorphology 15: 76–8 1, 2021 REVIEW ARTICLE Herbal advancements in the treatment to accelerate wound healing Lovely School of Applied Medical Sciences Shyam Bass*, Sheetu, Asees Kaur School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar, Punjab, India; * [email protected] Received: 11.05.2021 | Accepted: 15.06.2021 | Published: 23.06.2021 Abstract An injury or a wound is an anatomical and functional disturbance to the tissue. Wound healing is a complicated mechanism of tissue regeneration or remodelling that occurs in response to an injury. Plants and plant-derived constituents have long been used to heal and handle various forms of wounds. Currently, various forms of biopolymers are being studied in order to create a cost-effective, long-lasting, durable, and reliable delivery mechanism for the treatment of wounds. Wound treatment providers have revisited ancient healing practices by using conventional and complementary medicine in wound recovery due to the rise of multi-resistant pathogens and a decline in modern antibiotics. People’s attitudes toward alternative medicine have shifted as well, which is very positive. The idea of moist wound healing has gained a lot of attraction, and conventional medicine has begun to use it to speed up the healing process. In wound care treatment, several experiments using herbal and conventional medicine from various continents have been published. Keywords: Alternative medicine, complementary medicine, traditional medicine, wound