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Supplemental List 1 Supplemental List 1 IRB or IEC (name/address) , center name, and date of final approval IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) The IRB of Hokkaido University Hospital Hokkaido University Hospital, First Department of 17/MAR/2015 Medicine 5, Kita 14-jo Nishi, Kita-ku Hokkaido, Sapporo 060-8648 Japan The IRB of Teine Keijinkai Hospital Teine Keijinkai Clinic, Respiratory Medicine 02/MAR/2015 12-1-40, Maeda 1-jo Teineku Hokkaido, Sapporo 006-0811 Japan The IRB of Oji General Hospital Oji General Hospital, Department of Respiratory 24/FEB/2015 Medicine 3-4-8, Wakakusa-cho Hokkaido, Tomakomai 053-8506 Japan The IRB of Medical Corporation Choryo Idaimae Medical Corporation Choryo Idaimae Minamiyojo 24/FEB/2015 Minamiyojo Int Clinic Int Clinic, Respiratory Medicine 15-1-32, Minami 4-jo Nishi Chuo-ku Hokkaido, Sapporo IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 064-0804 Japan The IRB of Tohoku Medical and Pharmaceutical Tohoku Medical and Pharmaceutical University 21/APR/2015 University Wakabayashi Hospital Wakabayashi Hospital, Respiratory Medicine 2-29-1, Yamatomachi Wakabayashi-ku Miyagi, Sendai 984-8560 Japan The IRB of Makita Hospital Makita Hospital, Respiratory 26/FEB/2015 2-6-25, Shinkotoni 1-jo, Kita-ku Hokkaido, Sapporo 001-0901 Japan The IRB of Makita Hospital Mikami Internal and Respiratory Medicine Clinic, 26/FEB/2015 Respiratory Medicine 2-6-25, Shinkotoni 1-jo, Kita-ku Hokkaido, Sapporo 001-0901 Japan The IRB of Koizumi Clinic of Respiratory and Internal Koizumi Clinic of Respiratory and Internal 09/FEB/2015 Medicine Medicine, Respiratory 27-1-41, Minami 1-jo Nishi, Chuo-ku Hokkaido, Sapporo IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 064-0801 Japan The IRB of Obihiro Kokyukika Naika Hospital Obihiro Kokyukika Naika Hospi, Respiratory 16/FEB/2015 20-1, Higashi-5-jo Minami Hokkaido, Obihiro 080-0805 Japan The IRB of National Hospital Organization Asahikawa National Hospital Organization Asahikawa Medical 16/FEB/2015 Medical Center center,r, Clinical Trial Center, Clinical Research Coordinator 7-4048, Hanasaki-cho Hokkaido, Asahikawa 070-8644 Japan The IRB of Japan Community Health care Organization Japan Community Health care Organization 12/FEB/2015 Hokkaido Hospital Hokkaido Hospital 8-3-18, Nakanoshima 1-jo, Toyohira-ku Hokkaido, Sapporo 062-8618 Japan The IRB of Hakodate Goryoukaku Hospital Hakodate Goryoukaku Hospital,,Clinical Trial 25/MAR/2015 Center, Respiratotry 38-3, Goryokaku-cho Hokkaido, Hakodate IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 040-8611 Japan The IRB of Hakodate Municipal Hospital Hakodate Municipal Hospital,Clinical Trial Center, 19/FEB/2015 1-10-1, Minato-cho Respiratotry Hokkaido, Hakodate 041-8680 Japan The IRB of Koizumi Clinic of Respiratory and Internal Ohmichi Internal medicine and Respiratory Clinic, 09/FEB/2015 Medicine Respiratory 27-1-41, Minami 1-jo Nishi, Chuo-ku Hokkaido, Sapporo 064-0801 Japan The IRB of Hokkaido P.W.F.A.C Obihiro-Kosei General Hokkaido P.W.F.A.C Obihiro-Kosei General 25/MAR/2015 Hospital Hospital, Respiratory Medicine 8-1, Minami, Nishi 6-jo Hokkaido, Obihiro 080-0016 Japan The IRB of Otaru Kyokai Hospital Otaru Kyokai Hospital, respiratory 25/FEB/2015 1-6-15, Suminoe Hokkaido, Otaru 047-8510 IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) Japan The IRB of KKR Sapporo Medical Center KKR Sapporo Medical Center, Drug department 26/FEB/2015 6-3-40, Hiragishi 1-jyo, Toyohira-ku Hokkaido, Sapporo 062-0931 Japan The IRB of Iwate Medical University Hospital Iwate Medical University Hospital, Division of 19/FEB/2015 Pulmonary Medicine, Allergy and Rheumatology 19-1, Uchimaru Iwate, Morioka 020-8505 Japan The IRB of Tohoku University Hospital Tohoku University Hospital, Department of 23/FEB/2015 Respiratory Medicine 1-1, Seiryo-machi, Aoba-ku Miyagi, Sendai 980-8574 Japan The IRB of Tohoku Rosai Hospital Japan Organization of Occupational Health and 12/MAR/2015 Safety Tohoku Rosai Hospital 4-3-21, Dainohara, Aoba-ku Miyagi, Sendai 981-8563 Japan IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) The IRB of Sanyudo Hospital Sanyudo Hospital, Respiratory Medicine 10/MAR/2015 6-1-219, Chuo Yamagata, Yonezawa 992-0045 Japan The IRB of Fukushima Medical University Hospital Fukushima Medical University Hospital, Pulmonary 04/MAR/2015 Medicine 1, Hikarigaoka Fukushima, Fukushima 960-1295 Japan The IRB of Ibarakihigashi National Hospital National Hospital Organization Ibarakihigashi 19/FEB/2015 National Hospital, Respiratory Medicine 825, Terunuma, Tokai-mura Ibaraki, Naka-gun 319-1113 Japan The IRB of Review Board of Human Rights and Ethics for Hitachi, Ltd. Hitachinaka General Hospital, 03/MAR/2015 Clinical Studies Respiratory Medicine 13-2, Ichiban-cho, Tokyo,Chiyoda-ku 102-0082 Japan IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) The IRB of Outpatient, Fujioka General Hospital Outpatient, Fujioka General Hospital, Respiratory 25/FEB/2015 Diseases Department 813-1, Nakakurisu Gunma, Fujioka 375-0015 Japan The IRB of Review Board of Human Rights and Ethics for Tsuchiya Clinic, internal medicine 20/FEB/2015 Clinical Studies 13-2, Ichiban-cho, Tokyo,Chiyoda-ku 102-0082 Japan The IRB of Maebashi Red Cross Hospital Maebashi Red Cross Hospital, Respiratory medicine 23/FEB/2015 3-21-36, Asahi-cho Gunma, Maebashi 371-0014 Japan The IRB of Review Board of Human Rights and Ethics for Okano Clinic, Internal Medicine 20/FEB/2015 Clinical Studies 13-2, Ichiban-cho, Tokyo,Chiyoda-ku 102-0082 Japan IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) The IRB of Saitama Red Cross Hospital Saitama Red Cross Hospital, Internal Medicine 03/MAR/2015 8-3-33, Kamiochiai, Chuo-ku Saitama, Saitama 338-8553 Japan The IRB of Chiba University Hospital Chiba University Hospital, Respiratory Medicine 16/MAR/2015 1-8-1, Inohana, Chuo-ku Chiba, Chiba 260-8677 Japan The IRB of Tesshokai Kameda Clinic, Respiratory 17/FEB/2015 929, Higashi-cho Chiba, Kamogawa 296-0041 Japan The IRB of The Jikei University Hospital The Jikei University Hospital, Respiratory Medicine 24/FEB/2015 3-19-18, Nishishinbashi Tokyo, Minato-ku 105-8471 Japan The IRB of Tokyo Medical University Hospital Tokyo Medical University Hospital, Respiratory 09/MAR/2015 IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) Medicine 6-7-1, Nishishinjuku Tokyo, Shinjuku-ku 160-0023 Japan The IRB of National Hospital Organization Tokyo Medical National Hospital Organization Tokyo Medical 16/FEB/2015 Center Center, Respiratory 2-5-1, Higashigaoka Tokyo, Meguro-ku 152-8902 Japan The IRB of Nihon University Itabashi Hospital Nihon University Itabashi Hospital, Respiratory 24/FEB/2015 Medicine 30-1, Oyaguchi, Kami-cho Tokyo, Itabashi-ku 173-8610 Japan Tokyo-Eki Center-building Clinic Tokyo-Eki Center-building Clinic, Internal Medicine 17/FEB/2015 3-3-14, Nihonbashi Tokyo, Chuo-ku 103-0027 Japan The IRB of Sendai Hikarigaoka Spellman Hospital, Department of 10/MAR/2015 Internal Medicine IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 7-22-8, Sakuragaoka, Aoba-ku, Miyagi, Sendai 983-0833 Japan The IRB of Tokyo Medical University Hachioji Medical Tokyo Medical University Hachioji Medical Center, 26/FEB/2015 Center Respiratory 1163, Tatemachi Tokyo, Hachioji 193-0998 Japan The IRB of Tokyo-Eki Center-building Clinic Fukuwa Clinic 17/FEB/2015 3-3-14, Nihonbashi Tokyo, Chuo-ku 103-0027 Japan The IRB of Keio University Hospital Keio University Hospital, Division of Pulmonary 26/FEB/2015 Medicine 35, Shinanomachi Tokyo, Shinjuku-ku 160-8582 Japan The IRB of Center Hospital of the National Center for Center Hospital of the National Center for Global 19/FEB/2015 Global Health and Medicine Health and Medicine, Respiratory Medicine IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 1-21-1, Toyama Tokyo, Shinjuku-ku 162-8655 Japan The IRB of Teikyo University Hospital Teikyo University Hospital, Internal Medicine 24/FEB/2015 2-11-1, Kaga Tokyo, Itabashi-ku 173-8606 Japan The IRB of Federation of National Public Service Federation of National Public Service Personnel 02/MAR/2015 Personnel Mutual Aid Associations Tachikawa Hospital Mutual Aid Associations Tachikawa Hospital, Clinical Research Center, Clinical Research 4-2-22, Nishikicho Coordinator Tokyo, Tachikawa 190-8531 Japan The IRB of Koto Hospital Koto Hospital, Department of Respiratory medicine 09/MAR/2015 6-8-5, Ojima Tokyo, Koto-ku 136-0072 Japan The IRB of Sakayori Clinic Sakayori Clinic, Clinical Trial Center, Clinical 16/FEB/2015 Research Coordinator IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 2-26-3, Higashioi Tokyo, Shinagawa-ku 140-0011 Japan The IRB of Asai Dermatology Clinic Healthcare corporation Aigokai Kanamecho 16/FEB/2015 Hospital, Respiratory department 1-14, Katabira-cho, Hodogaya-ku, Kanagawa, Yokohama 240-0013 Japan The IRB of Kanagawa Cardiovascular and Respiratory Kanagawa Cardiovascular and Respiratory Center, 10/MAR/2015 Center Department of Respiratory medicine 6-16-1, Tomioka-higashi, Kanazawa-ku Kanagawa, Yokohama 236-0051 Japan The IRB of Tokai University Hospital Tokai University Hospital, Respiratory 25/FEB/2015 143, Shimokasuya Kanagawa, Isehara 259-1193 Japan The IRB of Yokohama City University Medical Center Yokohama City University Medical Center, 10/APR/2015 Respiratory Disease Center IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 4-57, Urafune-cho, Minami-ku Kanagawa, Yokohama
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