Supplemental List 1 IRB or IEC (name/address) , center name, and date of final approval IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) The IRB of Hokkaido University Hospital Hokkaido University Hospital, First Department of 17/MAR/2015 Medicine 5, Kita 14-jo Nishi, Kita-ku Hokkaido, Sapporo 060-8648 Japan The IRB of Teine Keijinkai Hospital Teine Keijinkai Clinic, Respiratory Medicine 02/MAR/2015

12-1-40, Maeda 1-jo Teineku Hokkaido, Sapporo 006-0811 Japan The IRB of Oji General Hospital Oji General Hospital, Department of Respiratory 24/FEB/2015 Medicine 3-4-8, Wakakusa-cho Hokkaido, Tomakomai 053-8506 Japan The IRB of Medical Corporation Choryo Idaimae Medical Corporation Choryo Idaimae Minamiyojo 24/FEB/2015 Minamiyojo Int Clinic Int Clinic, Respiratory Medicine

15-1-32, Minami 4-jo Nishi Chuo-ku Hokkaido, Sapporo IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 064-0804 Japan The IRB of Tohoku Medical and Pharmaceutical Tohoku Medical and Pharmaceutical University 21/APR/2015 University Wakabayashi Hospital Wakabayashi Hospital, Respiratory Medicine

2-29-1, Yamatomachi Wakabayashi-ku Miyagi, Sendai 984-8560 Japan The IRB of Makita Hospital Makita Hospital, Respiratory 26/FEB/2015

2-6-25, Shinkotoni 1-jo, Kita-ku Hokkaido, Sapporo 001-0901 Japan The IRB of Makita Hospital Mikami Internal and Respiratory Medicine Clinic, 26/FEB/2015 Respiratory Medicine 2-6-25, Shinkotoni 1-jo, Kita-ku Hokkaido, Sapporo 001-0901 Japan The IRB of Koizumi Clinic of Respiratory and Internal Koizumi Clinic of Respiratory and Internal 09/FEB/2015 Medicine Medicine, Respiratory

27-1-41, Minami 1-jo Nishi, Chuo-ku Hokkaido, Sapporo IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 064-0801 Japan The IRB of Obihiro Kokyukika Naika Hospital Obihiro Kokyukika Naika Hospi, Respiratory 16/FEB/2015

20-1, Higashi-5-jo Minami Hokkaido, Obihiro 080-0805 Japan The IRB of National Hospital Organization Asahikawa National Hospital Organization Asahikawa Medical 16/FEB/2015 Medical Center center,r, Clinical Trial Center, Clinical Research Coordinator 7-4048, Hanasaki-cho Hokkaido, Asahikawa 070-8644 Japan The IRB of Japan Community Health care Organization Japan Community Health care Organization 12/FEB/2015 Hokkaido Hospital Hokkaido Hospital

8-3-18, Nakanoshima 1-jo, Toyohira-ku Hokkaido, Sapporo 062-8618 Japan The IRB of Hakodate Goryoukaku Hospital Hakodate Goryoukaku Hospital,,Clinical Trial 25/MAR/2015 Center, Respiratotry 38-3, Goryokaku-cho Hokkaido, Hakodate IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 040-8611 Japan The IRB of Hakodate Municipal Hospital Hakodate Municipal Hospital,Clinical Trial Center, 19/FEB/2015 1-10-1, Minato-cho Respiratotry Hokkaido, Hakodate 041-8680 Japan The IRB of Koizumi Clinic of Respiratory and Internal Ohmichi Internal medicine and Respiratory Clinic, 09/FEB/2015 Medicine Respiratory

27-1-41, Minami 1-jo Nishi, Chuo-ku Hokkaido, Sapporo 064-0801 Japan The IRB of Hokkaido P.W.F.A.C Obihiro-Kosei General Hokkaido P.W.F.A.C Obihiro-Kosei General 25/MAR/2015 Hospital Hospital, Respiratory Medicine

8-1, Minami, Nishi 6-jo Hokkaido, Obihiro 080-0016 Japan The IRB of Otaru Kyokai Hospital Otaru Kyokai Hospital, respiratory 25/FEB/2015

1-6-15, Suminoe Hokkaido, Otaru 047-8510 IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) Japan The IRB of KKR Sapporo Medical Center KKR Sapporo Medical Center, Drug department 26/FEB/2015

6-3-40, Hiragishi 1-jyo, Toyohira-ku Hokkaido, Sapporo 062-0931 Japan The IRB of Iwate Medical University Hospital Iwate Medical University Hospital, Division of 19/FEB/2015 Pulmonary Medicine, Allergy and Rheumatology 19-1, Uchimaru Iwate, Morioka 020-8505 Japan The IRB of Hospital Tohoku University Hospital, Department of 23/FEB/2015 Respiratory Medicine 1-1, Seiryo-machi, Aoba-ku Miyagi, Sendai 980-8574 Japan The IRB of Tohoku Rosai Hospital Japan Organization of Occupational Health and 12/MAR/2015 Safety Tohoku Rosai Hospital 4-3-21, Dainohara, Aoba-ku Miyagi, Sendai 981-8563 Japan IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) The IRB of Sanyudo Hospital Sanyudo Hospital, Respiratory Medicine 10/MAR/2015

6-1-219, Chuo Yamagata, Yonezawa 992-0045 Japan The IRB of Fukushima Medical University Hospital Fukushima Medical University Hospital, Pulmonary 04/MAR/2015 Medicine 1, Hikarigaoka Fukushima, Fukushima 960-1295 Japan The IRB of Ibarakihigashi National Hospital National Hospital Organization Ibarakihigashi 19/FEB/2015 National Hospital, Respiratory Medicine 825, Terunuma, Tokai-mura Ibaraki, Naka-gun 319-1113 Japan The IRB of Review Board of Human Rights and Ethics for Hitachi, Ltd. Hitachinaka General Hospital, 03/MAR/2015 Clinical Studies Respiratory Medicine

13-2, Ichiban-cho, ,Chiyoda-ku 102-0082 Japan IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) The IRB of Outpatient, Fujioka General Hospital Outpatient, Fujioka General Hospital, Respiratory 25/FEB/2015 Diseases Department 813-1, Nakakurisu Gunma, Fujioka 375-0015 Japan The IRB of Review Board of Human Rights and Ethics for Tsuchiya Clinic, internal medicine 20/FEB/2015 Clinical Studies

13-2, Ichiban-cho, Tokyo,Chiyoda-ku 102-0082 Japan The IRB of Maebashi Red Cross Hospital Maebashi Red Cross Hospital, Respiratory medicine 23/FEB/2015

3-21-36, Asahi-cho Gunma, Maebashi 371-0014 Japan The IRB of Review Board of Human Rights and Ethics for Okano Clinic, Internal Medicine 20/FEB/2015 Clinical Studies

13-2, Ichiban-cho, Tokyo,Chiyoda-ku 102-0082 Japan IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) The IRB of Red Cross Hospital Saitama Red Cross Hospital, Internal Medicine 03/MAR/2015

8-3-33, Kamiochiai, Chuo-ku Saitama, Saitama 338-8553 Japan The IRB of Hospital Chiba University Hospital, Respiratory Medicine 16/MAR/2015

1-8-1, Inohana, Chuo-ku Chiba, Chiba 260-8677 Japan The IRB of Tesshokai Kameda Clinic, Respiratory 17/FEB/2015

929, Higashi-cho Chiba, Kamogawa 296-0041 Japan The IRB of The Jikei University Hospital The Jikei University Hospital, Respiratory Medicine 24/FEB/2015

3-19-18, Nishishinbashi Tokyo, Minato-ku 105-8471 Japan The IRB of Hospital Tokyo Medical University Hospital, Respiratory 09/MAR/2015 IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) Medicine 6-7-1, Nishishinjuku Tokyo, Shinjuku-ku 160-0023 Japan The IRB of National Hospital Organization Tokyo Medical National Hospital Organization Tokyo Medical 16/FEB/2015 Center Center, Respiratory

2-5-1, Higashigaoka Tokyo, Meguro-ku 152-8902 Japan The IRB of Hospital Nihon University Itabashi Hospital, Respiratory 24/FEB/2015 Medicine 30-1, Oyaguchi, Kami-cho Tokyo, Itabashi-ku 173-8610 Japan Tokyo-Eki Center-building Clinic Tokyo-Eki Center-building Clinic, Internal Medicine 17/FEB/2015

3-3-14, Nihonbashi Tokyo, Chuo-ku 103-0027 Japan The IRB of Sendai Hikarigaoka Spellman Hospital, Department of 10/MAR/2015 Internal Medicine IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY)

7-22-8, Sakuragaoka, Aoba-ku, Miyagi, Sendai 983-0833 Japan The IRB of Tokyo Medical University Hachioji Medical Tokyo Medical University Hachioji Medical Center, 26/FEB/2015 Center Respiratory

1163, Tatemachi Tokyo, Hachioji 193-0998 Japan The IRB of Tokyo-Eki Center-building Clinic Fukuwa Clinic 17/FEB/2015

3-3-14, Nihonbashi Tokyo, Chuo-ku 103-0027 Japan The IRB of Hospital Keio University Hospital, Division of Pulmonary 26/FEB/2015 Medicine 35, Shinanomachi Tokyo, Shinjuku-ku 160-8582 Japan The IRB of Center Hospital of the National Center for Center Hospital of the National Center for Global 19/FEB/2015 Global Health and Medicine Health and Medicine, Respiratory Medicine IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY)

1-21-1, Toyama Tokyo, Shinjuku-ku 162-8655 Japan The IRB of Hospital Teikyo University Hospital, Internal Medicine 24/FEB/2015

2-11-1, Kaga Tokyo, Itabashi-ku 173-8606 Japan The IRB of Federation of National Public Service Federation of National Public Service Personnel 02/MAR/2015 Personnel Mutual Aid Associations Tachikawa Hospital Mutual Aid Associations Tachikawa Hospital, Clinical Research Center, Clinical Research

4-2-22, Nishikicho Coordinator Tokyo, Tachikawa 190-8531 Japan The IRB of Koto Hospital Koto Hospital, Department of Respiratory medicine 09/MAR/2015

6-8-5, Ojima Tokyo, Koto-ku 136-0072 Japan The IRB of Sakayori Clinic Sakayori Clinic, Clinical Trial Center, Clinical 16/FEB/2015 Research Coordinator IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY)

2-26-3, Higashioi Tokyo, Shinagawa-ku 140-0011 Japan The IRB of Asai Dermatology Clinic Healthcare corporation Aigokai Kanamecho 16/FEB/2015 Hospital, Respiratory department 1-14, Katabira-cho, Hodogaya-ku, Kanagawa, Yokohama 240-0013 Japan The IRB of Kanagawa Cardiovascular and Respiratory Kanagawa Cardiovascular and Respiratory Center, 10/MAR/2015 Center Department of Respiratory medicine

6-16-1, Tomioka-higashi, Kanazawa-ku Kanagawa, Yokohama 236-0051 Japan The IRB of Hospital Tokai University Hospital, Respiratory 25/FEB/2015

143, Shimokasuya Kanagawa, Isehara 259-1193 Japan The IRB of Medical Center Yokohama City University Medical Center, 10/APR/2015 Respiratory Disease Center IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY)

4-57, Urafune-cho, Minami-ku Kanagawa, Yokohama 232-0024 Japan The IRB of Kokan Clinic Medical corporation kokankai kokan clinic, Internal 03/FEB/2015 Medicine 1-2-3, Kokandori, Kawasaki-ku Kanagawa, Kawasaki 210-0852 Japan The IRB of St. Marianna University School of Medicine St. Marianna University School of Medicine 16/MAR/2015 Hospital Hospital, Internal Medicine Division of Respiratory and Infectious Diseases 2-16-1, Sugao, Miyamae-ku Kanagawa, Kawasaki 216-8511 Japan The IRB of Yokohama Minoru Clinic Shinada Respiratory and Cardiovascular Clinic, 12/FEB/2015 Respiratory 1-13-8, Bessho, MInami-ku Kanagawa, Yokohama 232-0064 Japan The IRB of Teikyo University Hospital, Mizonokuchi Teikyo University Hospital, Mizonokuchi, Clinical 14/APR/2015 Trial Center IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY)

3-8-3, Mizonokuchi, Takatsu-ku Kanagawa, Kawasaki 213-8507 Japan The IRB of Sagamihara National Hospital National Hospital Organization Sagamihara National 18/FEB/2015 Hospital, Allergology 18-1, Sakuradai, Minami-ku Kanagawa, Sagamihara 252-0392 Japan The IRB of Nishi-Niigata Chuo National Hospital Nishi-Niigata Chuo National Hospital, Respiratory 18/FEB/2015 Medicine 1-14-1, Masago, Nishi-ku Niigata, Niigata 950-2085 Japan The IRB of Niigata Rinko Hospital Niigata Rinko Hospital, Internal Medicine 23/FEB/2015 Respiratory, 1-114-3, Momoyamacho, Higashi-ku Niigata, Niigata 950-0051 Japan The IRB of Medical and Dental Niigata University Medical & Dental Hospital, 24/FEB/2015 Hospital Internal Medicine Division of Respiratory and infectious Diseases IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY)

754, Asahimachidori 1-bancho, Chuo-ku Niigata, Niigata 951-8520 Japan The IRB of Kanazawa Municipal Hospital Kanazawa Municipal Hospital, Respiratory 13/MAR/2015

3-7-3, Heiwamachi Ishikawa, Kanazawa 921-8105 Japan The IRB of Fukui Prefectural Hospital Fukui Prefectural Hospital, Respiratory Medicine 04/FEB/2015

2-8-1, Yotsui Fukui, Fukui 910-8526 Japan The IRB of Yokohama Minoru Clinic Okubo Chest Clinic, Respiratory and Medicine 12/FEB/2015

1-13-8, Bessho, MInami-ku Kanagawa, Yokohama 232-0064 Japan The IRB of Review Board of Human Rights and Ethics for Koyama Medical Clinic, Internal Medicine 20/FEB/2015 Clinical Studies IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY)

13-2, Ichiban-cho, Tokyo,Chiyoda-ku 102-0082 Japan The IRB of Shinshu University Hospital Shinshu University Hospital, Respirology & 28/APR/2015 Infectious Disease 3-1-1, Asahi , Matsumoto 390-8621 Japan The IRB of Ogaki Municipal Hospital Ogaki Municipal Hospital, Respiratory Medicine 26/FEB/2015

4-86, Minaminokawacho Gifu, Ogaki 503-8502 Japan The IRB of Clinical Research Tokyo Hospital Tohno Chuo Clinic, Internal Medicine 26/FEB/2015

3-87-4, Haramachi, Tokyo, Shinjuku 162-0053 Japan The IRB of Tenryu Hospital National Hospital Organization Tenryu Hospital, 20/FEB/2015 Department of Internal Medicine IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 4201-2, Oro Hamakita-ku Shizuoka, Hamamatsu 434-8511 Japan The IRB of Shizuoka Prefectural Hospital Organization Shizuoka Prefectural Hospital Organization 25/MAR/2015 Shizuoka General Hospital Shizuoka General Hospital, Respiratory Medicine

4-27-1, Kita Ando, Aoi-ku Shizuoka, Shizuoka 420-8527 Japan The IRB of Tosei General Hospital Tosei General Hospital, Respiratory Medicine and 16/MAR/2015 Allergy 160, Nishioiwake-cho Aichi, Seto 489-8642 Japan The IRB of Nagoya University Hospital Nagoya University Hospital, Respirology 27/MAR/2015

65, Tsurumai-cho, Showa-ku Aichi, Nagoya 466-8560 Japan The IRB of National Hospital for Geriatric Medicine National Center for Geriatrics and Gerontology, 19/JUN/2015 Department of Pulmonary Medicine IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 7-430, Morioka-cho Aichi, Obu 474-0038 Japan The IRB of Clinical Research Tokyo Hospital Hiramatsu Internal & Respiratory Medecine Clinic, 26/FEB/2015 Respiratory 3-87-4, Haramachi, Tokyo, Shinjuku 162-0053 Japan The IRB of Japan Organization of Occupational Health and Japan Organization of Occupational Health and 16/FEB/2015 Safety Chubu Rosai Hospital Safety Chubu Rosai Hospital

1-10-6, Komei, Minato-ku Aichi, Nagoya 455-8530 Japan The IRB of Japan Community Health care Organization Japan Community Health care Organization Chukyo 26/FEB/2015 Chukyo Hospital Hospital, Respiratory Medicine

1-1-10, Sanjo, Minami-ku Aichi, Nagoya 457-8510 Japan The IRB of The Nippon Medical School The Respiratory Care Clinic, Nippon Medical 26/FEB/2015 School, Internal Medicine IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 4-7-15, Kudan-minami Tokyo, Chiyoda-ku 102-0074 Japan The IRB of Matsusaka City Hospital Matsusaka City Hospital, Respiratory Medicine 06/FEB/2015

1550, Tonomachi Mie, Matsusaka 515-8544 Japan The IRB of Kyoto University Hospital Kyoto University Hospital, Respiratory Medicine 18/MAR/2015

54, Shogoin-Kawaharacho, Sakyo-ku Kyoto, Kyoto 606-8507 Japan The IRB of Kindai University Hospital Kinki University Hospital, Faculty of Medicine, 23/MAR/2015 Respiratory Medicine and Allergology 377-2, Onohigashi Osaka, Osakasayama 589-8511 Japan The IRB of Osaka City University Hospital Osaka City University Hospital, Department of 25/FEB/2015 respiratory Medicine 1-5-7, Asahimachi, Abeno-ku IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) Osaka, Osaka 545-8586 Japan The IRB of Osaka Red Cross Hospital Osaka Red Cross Hospital, Respiratory 01/APR/2015 01/APR/2015 5-30, Fudegasaki-cho, Tennoji-ku Osaka, Osaka 543-8555 Japan The IRB of Takatsuki Red Cross Hospital Takatsuki Red Cross Hospital, Respiratory Division 20/FEB/2015

1-1-1, Abuno Osaka, Takatsuki 569-1096 Japan The IRB of Kishiwada City Hospital Kishiwada City Hospital, Department of Respiratory 16/FEB/2015 Medicine 1001, Gakuhara-cho Osaka, Kishiwada 596-8501 Japan The IRB of Tomisaka Clinic Sasaki naika clinic, Respiratory medicine 04/FEB/2015

1-33-9, Hongo, Tkyo, Bunkyo IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY)

113-0033 Japan The IRB of National Hospital Organization Toneyama National Hospital Organization Toneyama National 20/FEB/2015 National Hospital Hospital, Respiratory medicine

5-1-1, Toneyama Osaka, Toyonaka 560-8552 Japan The IRB of Osaka Saiseikai Nakatsu Hospital Osaka Saiseikai Nakatsu Hospital , Respiratory 03/MAR/2015 Medicine 2-10-39, Shibata, Kita-ku Osaka, Osaka 530-0012 Japan The IRB of Tokushukai Group Yao Tokushukai General Hospital, The internal 23/FEB/2015 department 1-8-7, Kojimachi Tokyo, Chiyoda 581-0011 Japan The IRB of Japan Community Health care Organization Japan Community Health care Organization Osaka 17/FEB/2015 Osaka Hospital Hospital, Internal Medicine

4-2-78, Fukushima, Fukusima-ku IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) Osaka, Osaka 553-0003 Japan The IRB of Ikeda Municipal Hospital Ikeda Municipal Hospital, Respiratory Medicine 02/FEB/2015

3-1-18, Jonan Osaka, Ikeda 563-8510 Japan The IRB of National Hospital Organization Himeji National Hospital Organization Himeji Medical 25/FEB/2015 Medical Center Center, Respiratory tract medicine

68, Honmachi Hyogo, Himeji 670-8520 Japan The IRB of Kobe City Hospital Organization Kobe City Kobe City Medical Center General Hospital, 09/MAR/2015 Medical Center General Hospital Respiratory Medicine

2-1-1, Minatojimaminamimachi, Chuo-ku Hyogo, Kobe 650-0047 Japan The IRB of Hyogo College of Medicine Hospital Hyogo College Of Medicine College Hospital, 25/MAR/2015 Respiratory 1-1, Mukogawacho IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) Hyogo, Nishinomiya 663-8501 Japan The IRB of Nakatani Hospital Nakatani Hospital, Internal Medicine 19/FEB/2015

2501, Hosoe, Shikama-ku Hyogo, Himeji 672-8064 Japan The IRB of Nara Hospital Kinki University Faculty of Nara Hospital Kinki University Faculty of Medicine, 10/APR/2015 Medicine Department of Respiratory Medicine and Allergology 1248-1, Otodacho Nara, Ikoma 630-0293 Japan The IRB of Wakayama Medical University Hospital Wakayama Medical University Hospital, Third 24/FEB/2015 Department of Internal Medicine 811-1, Kimiidera Wakayama, Wakayama 641-8510 Japan The IRB of Wakayama National Hospital Wakayama National Hospital, Respiratory Medicine, 12/MAR/2015 Department of pharmacy, Shuji Masamichi 1138, Oazawada, Mihama-cho IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) Wakayama, Hidaka-gun 644-0044 Japan The IRB of Shimane University Hospital Shimane University Hospital, Division of Medical 12/FEB/2015 Oncology and Respiratory Medicine 89-1, Enya-cho Shimane, Izumo 693-8501 Japan The IRB of Shimane Prefectural Central Hospital Shimane Prefectural Central Hospital, Respiratory 19/FEB/2015

4-1-1, Himebara Shimane, Izumo 693-8555 Japan The IRB of Kawasaki Hospital , Kawasaki Medical School Kawasaki Medical School General Medical Center 04/MAR/2015

2-1-80, Nakasange, Kita-ku Okayama, Okayama 700-8505 Japan The IRB of Chugoku Central Hospital Public school building cooperative association 17/MAR/2015 Chugoku central hospital, Respiratory internal 148-13, Kamiiwanari, Miyuki-cho medicine Hiroshima, Fukuyama IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 720-0001 Japan The IRB of National Hospital Organization Kure Medical National Hospital Organization Kure Medical Center 13/MAR/2015 Center and Chugoku Cancer Center and Chugoku Cancer Center, Respiratory medicine

3-1, Aoyama-cho Hiroshima, Kure 737-0023 Japan The IRB of Kure Kyosai Hospital Federation of National Public Services and Affiliated 10/FEB/2015 Personnel Mutual Aid Associations Kure Kyosai 2-3-28, Nishichuo Hospital, Respiratory Medicine Hiroshima, Kure 737-8505 Japan The IRB of Hiroshima Prefectural Hospital Hiroshima Prefectural Hospital, Respiratory internal 27/FEB/2015 medicine 1-5-54, Ujinakanda, Minami-ku Hiroshima, Hiroshima 734-8530 Japan The IRB of Yokohama Minoru Clinic Sentohill Hospital, Allergology and respiratory 26/FEB/2015 medicine 1-13-8, Bessho, MInami-ku Kanagawa, Yokohama IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 232-0064 Japan The IRB of National Hospital Organization Iwakuni National Hospital Organization Iwakuni Clinical 05/FEB/2015 Clinical Center Center, Respiratory Medicine

1-1-1, Atagomachi Yamaguchi, Iwakuni 740-8510 Japan The IRB of Takamatsu Municipal Hospital Takamatsu Municipal Hospital, Respiratory 26/FEB/2015 Medicine 2-36-1, Miyawaki Cho Kagawa, Takamatsu 760-8538 Japan The IRB of Sakaide City Hospital Sakaide City Hospital, Department of Internal 27/FEB/2015 Medicine 3-1-2, Kotobuki-cho Kagawa, Sakaide 762-8550 Japan The IRB of Nihonbashi Sakura Clinic Kamei Internal medicine and Respiratory Clinic, 18/FEB/2015 Internal medicine and Respiratory 1-9-2, Kayaba-cho, Nihonbashi, Tokyo, Chuo IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 103-0025 Japan The IRB of Yokohama Minoru Clinic Yokohama Minoru Clinic, Internal medicine, 12/FEB/2015

1-13-8, Bessho, MInami-ku Kanagawa, Yokohama 232-0064 Japan The IRB of Kurume University Hospital Kurume University, Clinical Trial Center, Division 16/FEB/2015 Of Respirology, Neurology And Rheumatology,

67, Asahi-machi Department Of Medicine Fukuoka, Kurume 830-0011 Japan The IRB of K-YOU HEALTH CARE Co. KIRIGAOKA K-YOU HEALTH CARE Co. KIRIGAOKA 26/FEB/2015 TSUDA HOSPITAL TSUDA HOSPITAL, Internal Medicine

3-9-20, Kirigaoka, Kokurakita-ku Fukuoka, Kitakyushu-city 802-0052 Japan The IRB of National Hospital Organization Fukuoka- National Hospital Organization Fukuoka-higashi 20/FEB/2015 higashi Medical Center Medical Center, Respiratotry

1-1-1, Chidori IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) Fukuoka, Koga 811-3195 Japan The IRB of Seiwakai Medical Corporation Nagata Hospital Seiwakai Medical Corporation Nagata Hospital, 16/FEB/2015 Department of Respiratory Medicine 523-1, Shimomiyanaga-machi Fukuoka, Yanagawa 832-0059 Japan The IRB of Nihonbashi Sakura Clinic Shin Yukuhashi Hospital, Internal Medicine 18/FEB/2015

1-9-2, Kayaba-cho, Nihonbashi, Tokyo, Chuo 103-0025 Japan The IRB of International University of health and welfare Fukuoka Sanno Hospital, Department of respiratory 12/FEB/2015 Kyusu area medicine

3-6-45, Sawara-ku,Momochihama Fukuoka, Fukuoka 814-0001 Japan The IRB of Japanese Red Cross Nagasaki Genbaku Japanese Red Cross Nagasaki Genbaku Isahaya 20/FEB/2015 Isahaya Hospital Hospital, Respiratory Medicine

IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 986-2, Keya, Tarami-cho Nagasaki, Isahaya 859-0497 Japan The IRB of Kagoshima University Medical And Dental Kagoshima University Medical And Dental Hospital, 23/FEB/2015 Hospital Department of Pulmonary Medicine

8-35-1, Sakuragaoka Kagoshima, Kagoshima 890-8520 Japan The IRB of Nihonbashi Sakura Clinic Healthcare corporation H.S.R Nakamura clinic, 18/FEB/2015 Inrernal Medicine 1-9-2, Kayaba-cho, Nihonbashi, Tokyo, Chuo 103-0025 Japan The IRB of Okinawa Prefectural Chubu Hospital Okinawa Prefectural Chubu Hospital, Respiratory 17/FEB/2015 Medicine 281, aza-Miyazato Okinawa, Uruma 904-2293 Japan The IRB of Hospital Showa University Hospital, Clinical Trial Support 27/JUL/2015 Center IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) 1-5-8, Hatanodai Tokyo, Shinagawa-ku 142-8666 Japan The IRB of Jichi Medical University Hospital Jichi Medical University Hospital, Department of 24/JUL/2015 Clinical Trial Promotion 3311-1, Yakushiji Tochigi, Shimotsuke 329-0498 Japan The IRB of Hospital Yamagata University Hospital, Clinical Trial Center 01/SEP/2015

2-2-2, Iidanishi Yamagata, Yamagata 990-9585 Japan The IRB of Okayama University Hospital Okayama University Hosipital, Division of Clinical 21/JUL/2015 Research of New Drugs and Therapeutics 2-5-1, Shikata-cho, Kita-ku Okayama, Okayama 700-8558 Japan The IRB of Tokyo Women's Medical University Hospital Tokyo Women's Medical University 10/JUL/2015 Hospital,Pulmonology 8-1, Kawada-cho IRB or IEC (name/address) Center Date of Final Approval (DD/MMM/YYYY) Tokyo, Shinjuku-ku 162-8666 Japan The IRB of Shiga University of Medical Science Hospital Shiga University of Medical Science Hospital, 23/JUL/2015 Respiratory Medicine Seta, Tsukinowa-cho Shiga, Otsu 520-2192 Japan The IRB of Tokyo Medical University Ibaraki Medical Tokyo Medical University Ibaraki Medical Center, 10/AUG/2015 Center Respiratory Medicine

3-20-1, Chuo, Amimachi Ibaraki, Inashiki-gun 300-0395 Japan The IRB of Kochi Medical School Hospital Kochi Medical School Hospital, Department of 28/SEP/2015 Hematology and Respiratory Medicine 185-1, Kohasu, Oko-cho Kochi, Nankoku 783-8505 Japan