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Rikiya Watanabe JST CREST-PRESTO joint international symposium ― Structural Biological Dynamics: From Molecules to Life with 60 trillion Cells ― November 5-6, 2015 (Thursday & Friday) Ito Hall, Ito International Research Center, The University of Tokyo Program organizers Plenary Speakers Tadashi Yamamoto Nahum Sonenberg Okinawa Institute of Science and Technology McGill University (OIST) Andrea Musacchio Soichi Wakatsuki Max-Planck Institute of Molecular Physiology SLAC National Accelerator Laboratory Stanford University Ian A. Wilson Scripps Research Institute Keiji Tanaka Tokyo Metropolitan Institute of Medical Science Plenary Speakers Hiroki Ueda Ursula Klingmüller The University of Tokyo/RIKEN QBiC German Cancer Research Center (DKFZ) Yifan Cheng University of California, San Francisco Feng Zhang Broad Institute of MIT and Harvard / Massachusetts Institute of Technology JST CREST-PRESTO joint international symposium Welcome Note It is our great pleasure to invite you to participate in Tadashi Yamamoto Professor, the Okinawa Institute of the international symposium, “Structural Biological Science and Technology Dynamics: From Molecules to Life with 60 trillion Program Officer at CREST Cells” . elcome“Biodynamics” WRecently, our CREST and PRESTO programs have been tackling the understanding of hierarchical dynamics (from molecules to life with 60 trillion cells) of biological phenomena via interdisciplinary analyses. The symposium focuses on recent Keiji Tanaka developments in systems biology, synthetic biology, Director, the Tokyo Metropolitan structural biology, and other relevant areas. It also Institute of Medical Science aims to increase the exchange of scientific knowledge Program Officer at CREST “Structural between local and international scientists in order to Life Science” provide an integrated approach on understanding the hierarchical biological dynamics, and to discuss various approaches to further the development of those areas. This will be a great opportunity for all of you to acquire the latest information and recent advances through networking and oral/poster Soichi Wakatsuki presentation. Professor, the SLAC National Accelerator Laboratory/Stanford University Program Officer at PRESTO “Structural Life Science” Hiroki Ueda Professor, the University of Tokyo/RIKEN QBiC Program Officer at PRESTO “Design and Control of Cellular functions” Dear colleagues, Yoshiko Shirokizawa On April 1, 2015, the government of Japan Executive Director, JST established the National Research and Development Agencies by transforming the former Independent Administrative Agencies for R&D, including JST elcome (Japan Scienceote and Technology Agency). The NNational Research and Development Agencies have greater flexibility in institutional management based on the characteristics of R&D agencies, and at the same time greater responsibility to maximize research achievements. On the occasion of institutional transformation, JST, as the core agency in the furtherance of Japan’ s STI, will further optimize its virtual network-based research institution structure and strive for higher achievements in contributing to the acceleration of Japan’ s growth strategies and realization of a sustainable society. We are delighted to invite you to participate in the “JST CREST-PRESTO joint international symposium—Structural Biological Dynamics: From Molecules to Life with 60 trillion Cells” to be held on November 5–6, 2016, in Tokyo, Japan. The CREST and PRESTO are some of JST’ s main strategic basic research programs, striving to lead the world in research excellence. The symposium features hot topics within highly relevant areas of systems biology, synthetic biology, and structural biology. This time, we are inviting leading scientists from overseas, and from four CREST-PRESTO programs, who are exploring biological principles to address current and future developments. We expect this symposium to provide a platform for networking and for fostering research collaborations with participants or with researchers worldwide. JST CREST-PRESTO joint international symposium Program Thursday, November 5, 2015 12:00 - 13:00 Registration 13:00 - 13:10 Welcome Message Tadashi Yamamoto Session 1 Biology and gene regulation Chair: Tadashi Yamamoto 13:10 - 13:40 Translational control of cancer and autism …………………………………………… 2 Nahum Sonenberg（McGill University） 13:40 - 14:00 Identifi cation of a sleep regulatory circuit and implications for the function and evolution of REM sleep ……………………………………………………………… 3 Yu Hayashi（University of Tsukuba） 14:00 - 14:25 Oscillatory control of neural stem cells ………………………………………………… 4 Ryoichiro Kageyama（Kyoto University） 14:25 - 14:35 Break Session 2 Cellular module Chair: Masasuke Yoshida 14:35 - 15:05 The role of kinetochores in chromosome segregation and feedback control of cell division ………………………………………………………… 5 Andrea Musacchio（Max Planck Institute of Molecular Physiology） 15:05 - 15:25 Transport toward the center of the cell: structure & mechanism of cytoplasmic dynein ………………………………………………………………………… 6 Takahide Kon（Osaka University） 15:25 - 15:50 Proton pumping mechanism coupled with electron transfer of bovine cytochrome c oxidase …………………………………………………………… 7 Tomitake Tsukihara（University of Hyogo） 15:50 - 16:10 Molecular mechanism of V1 rotary motor ……………………………………………… 8 Takeshi Murata（Chiba University） 16:10 - 16:20 Break Session 3 In vivo function and structure Chair: Keiji Tanaka 16:20 - 16:50 Broad Neutralization of Infl uenza Viruses and Implications for a Universal Vaccine and Therapy …………………………………………………… 9 Ian A. Wilson（Scripps Research Institute） 16:50 - 17:15 Structural study of TLR8 sensing single stranded RNA in innate immune system ………………………………………………………………………… 10 Toshiyuki Shimizu（The University of Tokyo） 17:15 - 17:35 Structural insight into multitasking molecular chaperone Trigger Factor ……… 11 Tomohide Saio（Hokkaido University） 17:35 - 18:00 Structural Basis of Bacterial Multidrug Effl ux Pumps and Development of Pump Inhibitors ………………………………………………………………………… 12 Akihito Yamaguchi（Osaka University） 18:00 - 18:10 Break 18:10 - 20:50 Poster Presentation & Reception Friday, November 6, 2015 9:00-10:00 Registration Session 4 Biological dynamics Chair: Tetsu Akiyama 10:00-10:30 Systems medicine ‒ from molecules to patients …………………………………… 13 Ursula Klingmüller（The German Cancer Research Center ） 10:30-10:50 Generating diverse organ buds from stem cells …………………………………… 14 Takanori Takebe（Yokohama City University） 10:50-11:15 Temporal Coding and Transomic Analysis of Insulin Action ……………………… 15 Shinya Kuroda（The University of Tokyo） 11:15-13:00 On Own for Lunch & Poster Viewing Session 5 State-of-the-art biological technologies Chair: Junichi Takagi 13:00-13:30 Structures of TRP ion channels by single particle cryo-EM ………………………… 16 Yifan Cheng（University of California, San Francisco） 13:30-13:55 Direct Visualization of Protein Molecules in Dynamic Action by High-speed Atomic Force Microscopy …………………………………………… 17 Toshio Ando（Kanazawa University） 13:55-14:15 Novel arrayed lipid bilayer chamber system for highly sensitive analysis of membrane transporters ………………………………………………………………… 18 Rikiya Watanabe（The University of Tokyo） 14:15-14:40 Probing the biological dynamics using Zero-Mode Waveguides ………………… 19 Sotaro Uemura（The University of Tokyo） 14:40-14:50 Break Session 6 State-of-the-art biological technologies and biological dynamics Chair: Hiroki Ueda 14:50-15:20 Development and Applications of CRISPR-Cas9 for Genome Editing …………… 20 Feng Zhang（Broad Institute of MIT and Harvard / Massachusetts Institute of Technology） 15:20-15:40 Carrying skeletal elements by novel type of cells enables the self-organizing construction of 4D skeleton of sponges ……………………………………………… 21 Noriko Funayama（Kyoto University） 15:40-16:05 Roles of the tight junction (TJ)-apical complex in epithelial morphogenetic dynamics ………………………………………………………………………………… 22 Sachiko Tsukita（Osaka University） 16:05-16:25 A synthetic approach to understanding protein molecules ……………………… 23 Nobuyasu Koga（Institute for Molecular Science） 16:25-16:30 Closing remarks Yoshiko Shirokizawa（JST） JST CREST-PRESTO joint international symposium General Information Venue Ito International Research Center B2F 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Entrance Tel：+81-3-5841-0779 (9:00-17:30, Weekdays only) Fax：+81-3-5841-0932 E-mail：[email protected] Access Information：http://www.u-tokyo.ac.jp/ext01/iirc/en/access.html From the Entrance Poster Exhibition Area Reception Desk Hall B2F Please come to the Reception Desk Hall Layout（Ito Hall B2F） Notes 1. No power outlets are available nearby audience seats 2. Eating and drinking are prohibited in the Ito Hall 3. No smoking on the premises 4. Wireless LAN is available Poster Presentation & Reception (18:10-20:50) Event Space (Ito International Research Center) Please pay 5,000JPY for your participation in advance at the reception desk of the symposium. Structural Biological Dynamics: From Molecules to Life with 60 trillion Cells Oral Presentation Session 1 Biological principles 13:10-13:40, November 5 Translational control of cancer and autism Nahum Sonenberg ABSTRACT McGill University, Canada Prof. Dr. Nahum Sonenberg joined the Translational control plays a critical role in the regulation of Roche Institute of Molecular Biology essential cellular processes including cell growth, proliferation, in Nutley after receiving his Ph.D. at development, and learning and memory. mRNA translation the Weizmann Institute of Science. He is dysregulated
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