Table S1. Up or down regulated in Tcof1 heterozygous haploinsufficiency mutant mice embryos involved in differentbiological process analysed by DAVID database Pop Pop Fold Term PValue Genes Bonferroni Benjamini FDR Hits Total Enrichment GO:0006793~phosphorus metabolic process 2.53E-07 RNASEL, CAPZA2, 4930444A02RIK, LPAR3, 866 13588 1.553518 8.11E-04 8.11E-04 4.59E-04

PSKH1, AAK1, B230120H23RIK, MAP3K8, PTPRK,

BRAF, CSNK1G1, GM5951, MYLK4, PIK3CD, WNK1,

PIM3, WNK2, CDKL3, STK4, PTPDC1, MARK1,

MAP4K5, LOC100044742, ACAP1, NEK4, NEK6,

WNT5A, GM8783, STK16, GNAI2, MVD, PTK7,

STK17B, M

GO:0006796~phosphate metabolic process 2.53E-07 RNASEL, CAPZA2, 4930444A02RIK, LPAR3, 866 13588 1.553518 8.11E-04 8.11E-04 4.59E-04

PSKH1, AAK1, B230120H23RIK, MAP3K8, PTPRK,

BRAF, CSNK1G1, GM5951, MYLK4, PIK3CD, WNK1,

PIM3, WNK2, CDKL3, STK4, PTPDC1, MARK1,

MAP4K5, LOC100044742, ACAP1, NEK4, NEK6,

WNT5A, GM8783, STK16, GNAI2, MVD, PTK7,

STK17B, M

GO:0016310~phosphorylation 8.10E-06 RNASEL, CAPZA2, 4930444A02RIK, LPAR3, 718 13588 1.52782 0.025664 0.012915 0.014693

PSKH1, AAK1, B230120H23RIK, MAP3K8, BRAF,

CSNK1G1, MYLK4, PIK3CD, WNK1, PIM3, WNK2,

CDKL3, STK4, MARK1, MAP4K5, ACAP1, NEK4,

NEK6, WNT5A, STK16, GNAI2, MVD, STK17B,

MAPKAPK3, PTK7, EPHA10, ATP6V1B2,

ATP6V0C-PS2, GM100

GO:0015931~nucleobase, nucleoside, nucleotide and nucleic 1.55E-05 NCBP2, ENY2, NUP133, XPO1, GM5643, SLC25A4, 74 13588 2.936827 0.048626 0.016479 0.028169 acid transport HNRNPA2B1, NUP188, NUPL2, HNRNPA1, NUPL1,

TMEM48, NUP62, DDX19A, SEH1L, NPM1, BAT1A,

NUP54, GLE1, THOC3, SLC28A3, THOC1

GO:0050658~RNA transport 3.58E-05 NCBP2, ENY2, NUP133, XPO1, GM5643, 66 13588 2.979206 0.108617 0.028336 0.064964

HNRNPA2B1, NUP188, NUPL2, HNRNPA1, NUPL1,

TMEM48, NUP62, DDX19A, SEH1L, NPM1, BAT1A,

NUP54, GLE1, THOC3, THOC1

GO:0050657~nucleic acid transport 3.58E-05 NCBP2, ENY2, NUP133, XPO1, GM5643, 66 13588 2.979206 0.108617 0.028336 0.064964

HNRNPA2B1, NUP188, NUPL2, HNRNPA1, NUPL1,

TMEM48, NUP62, DDX19A, SEH1L, NPM1, BAT1A,

NUP54, GLE1, THOC3, THOC1

GO:0051236~establishment of RNA localization 3.58E-05 NCBP2, ENY2, NUP133, XPO1, GM5643, 66 13588 2.979206 0.108617 0.028336 0.064964

HNRNPA2B1, NUP188, NUPL2, HNRNPA1, NUPL1,

TMEM48, NUP62, DDX19A, SEH1L, NPM1, BAT1A,

NUP54, GLE1, THOC3, THOC1

GO:0007156~homophilic cell adhesion 4.01E-05 CADM3, CADM1, LOC100046008, PCDHGA9, 117 13588 2.388189 0.12068 0.025393 0.07266

PCDHGA8, PCDHGA7, PCDHGC5, L1CAM, PCDHGA6,

PCDHGC4, PCDHGA5, PCDHGC3, PCDHGA4,

PCDHGA3, PCDHGA2, PCDHGA1, CDH22, PCDHGB1,

PCDHGA12, PCDHGA10, PCDHGA11, PCDHB5,

PCDHB4, PCDH10, PCDHGB7, PCDH12, PCDHGB6,

CELSR2, PCDHGB8,

GO:0006403~RNA localization 4.46E-05 NCBP2, ENY2, NUP133, XPO1, GM5643, 67 13588 2.93474 0.133425 0.023585 0.080905

HNRNPA2B1, NUP188, NUPL2, HNRNPA1, NUPL1,

TMEM48, NUP62, DDX19A, SEH1L, NPM1, BAT1A,

NUP54, GLE1, THOC3, THOC1 GO:0006974~response to DNA damage stimulus 5.44E-05 MMS19, MORF4L1, HMGN1, XRCC4, ZMAT3, 287 13588 1.80293 0.160128 0.024621 0.098579

MORF4L2, 2310003H01RIK, FOXO3, PMAIP1,

XRCC1, 2210018M11RIK, AEN, NSMCE1, PRMT6,

FANCB, RTEL1, CIB1, POLK, REV1, BRCC3,

1110054O05RIK, LIG3, UBE2B, ESCO2, JMY,

CCND1, UHRF1, RIF1, PSEN1, LOC100044391,

RAD18, RAD23B, HM

GO:0034613~cellular localization 7.91E-05 SRP14, XPO1, CLTA, OXA1L, AP4E1, GRIK2, 299 13588 1.765183 0.224187 0.031232 0.143366

AP2S1, PAX6, TOMM20L, PMAIP1, PEX7, AIP,

CDC42, AP1S2, ANK2, SRPR, COPB1, GM2423,

GM14494, SEC24D, SAR1A, SEC23A, STX6,

SRP54A, SRP54B, SRP54C, TIMM8B, VTI1A,

TOMM20, SRP72, COPG, STON2, ARL6IP1, AP1M1,

AP1M2, RAB6,

GO:0006397~mRNA processing 9.34E-05 NCBP2, RNASEL, RNMT, SNRPD3, GM11847, WBP4, 262 13588 1.816968 0.259101 0.032772 0.16935

YBX1, SMNDC1, TARDBP, PCBP1, BAT1A, PABPN1,

GM5643, HNRNPA2B1, DDX39, GM8186, ESRP1,

CPSF6, SLU7, CELF1, ESRP2, SNRPE, THOC3,

THOC1, SNRPG, PRPF38A, GM11793, PPIL1,

SF3B4, NAA38, HNRNPA3, SF3B1, SFRS15,

HNRNPF,

GO:0070727~cellular macromolecule localization 9.40E-05 SRP14, XPO1, CLTA, OXA1L, AP4E1, GRIK2, 301 13588 1.753454 0.260382 0.029712 0.170326

AP2S1, PAX6, TOMM20L, PMAIP1, PEX7, AIP,

CDC42, AP1S2, ANK2, SRPR, COPB1, GM2423,

GM14494, SEC24D, SAR1A, SEC23A, STX6,

SRP54A, SRP54B, SRP54C, TIMM8B, VTI1A, TOMM20, SRP72, COPG, STON2, ARL6IP1, AP1M1,

AP1M2, RAB6,

GO:0006468~protein amino acid phosphorylation 9.65E-05 RNASEL, BCKDK, CAPZA2, 4930444A02RIK, 640 13588 1.487643 0.266343 0.027763 0.174892

LPAR3, EIF2A, ACVR1C, PSKH1, PAK3, AAK1,

B230120H23RIK, MAP3K8, FERT2, PAK1, CDK16,

CHUK, SIK3, CDK14, ADAM10, CAMK1G, BRAF,

CSNK1G1, MTAP2, MYLK4, LOC100048768, WNK1,

CDK9, PIM3, WNK2, CDK7, CDKL3, STK4, MARK1,

DAPK1

GO:0006396~RNA processing 1.54E-04 NCBP2, RNASEL, RNMT, SNRPD3, TRMT2A, 437 13588 1.586661 0.390907 0.040474 0.279817

GM11847, WBP4, YBX1, SMNDC1, INTS5,

LOC623245, TARDBP, PCBP1, BAT1A, FTSJ1,

ZCCHC6, PABPN1, KRR1, GM5643, RPP21, EXOSC7,

EXOSC4, HNRNPA2B1, GM14138, GM6476,

GM11263, DDX39, LARP7, GM8186, ESRP1,

GM4796, CPSF6, SLU7, CE

GO:0051028~mRNA transport 1.95E-04 NCBP2, ENY2, NUP133, XPO1, GM5643, NUP188, 62 13588 2.83758 0.465668 0.047067 0.353596

NUPL2, HNRNPA1, NUPL1, TMEM48, NUP62,

DDX19A, SEH1L, BAT1A, NUP54, GLE1, THOC3,

THOC1

GO:0016071~mRNA metabolic process 1.97E-04 NCBP2, RNASEL, RNMT, SNRPD3, GM11847, WBP4, 302 13588 1.713381 0.468441 0.044135 0.356526

YBX1, AUH, SMNDC1, PCBP1, TARDBP, BAT1A,

1500002O20RIK, PABPN1, GM5643, HNRNPA2B1,

DDX39, GM8186, ESRP1, CPSF6, SLU7, CELF1,

ESRP2, SNRPE, THOC3, SNRPG, THOC1, PRPF38A,

GM11793, PPIL1, SF3B4, NAA38, HNRNPA3, SF3 GO:0046907~intracellular transport 3.13E-04 NCBP2, XPO1, SRP14, CLTA, AP4E1, GRIK2, 431 13588 1.560727 0.633842 0.064785 0.566225

AP2S1, TOMM20L, PEX7, AIP, CDC42, ANKRD54,

AP1S2, SRPR, COPB1, GM2423, GLE1, GM14494,

SEC24D, SAR1A, STX6, SEC23A, NUP133, ADAM10,

GM5643, LOC100048600, SRP54A, SRP54B,

SRP54C, MYH6, TIMM8B, VTI1A, PSEN1, TOMM20,

SR

GO:0008380~RNA splicing 4.14E-04 NCBP2, GM11793, PPIL1, SNRPD3, GM11847, 201 13588 1.85352 0.734896 0.079628 0.74755

NAA38, SF3B4, WBP4, YBX1, SMNDC1, HNRNPA3,

SF3B1, HNRNPF, TARDBP, USP39, BAT1A, HNRNPC,

PABPC1, GEMIN6, SFRS14, PPWD1, GEMIN5,

TXNL4B, GM5643, HNRNPA2B1, LOC100047806,

SF3A2, HNRNPA1, DDX39, SFPQ, GM8186, ESRP1,

SLU

GO:0016477~cell migration 4.23E-04 CER1, NRP2, NRP1, SOX1, FGF15, CAPZA2, 240 13588 1.767923 0.743049 0.076822 0.76507

ATP5B, ASTN1, PAX6, GJA1, ABI2, GIPC1,

GM6212, PAX3, CD24A, PTEN, PEX7, ARX, DAB1,

CTGF, CLASP2, CAP1, TOP2B, PRRXL1, ARID5B,

NR4A2, DBH, ISL1, FEZF1, SMO, CORO1A, NUP62,

NAV1, PSEN1, BAX, MNX1, FOXC1, ALKBH1, LRP8,

GO:0016337~cell-cell adhesion 5.89E-04 CADM3, CADM1, LOC100046008, PCDHGA9, 236 13588 1.754037 0.84931 0.099802 1.063929

PCDHGA8, PCDHGA7, PCDHGA6, L1CAM, GM6212,

PCDHGA5, PCDHGA4, PCDHGA3, PCDHGA2,

PCDHGA1, CDH22, CDC42, PCDHGB1, DAB1, CTGF,

VNN1, PCDHGA12, PCDHGA10, PCDHGA11, ICAM4,

PCDHB5, PCDHB4, PCDHGB7, PCDHGB6, PCDH7, PCDHGB8, PCD

GO:0006886~intracellular protein transport 5.99E-04 XPO1, SRP14, CLTA, AP4E1, GRIK2, AP2S1, 276 13588 1.687308 0.854074 0.096336 1.081889

TOMM20L, AIP, PEX7, AP1S2, SRPR, COPB1,

GM2423, GM14494, SAR1A, SEC24D, SEC23A,

STX6, SRP54A, SRP54B, SRP54C, TIMM8B, VTI1A,

TOMM20, SRP72, COPG, ARL6IP1, STON2, AP1M1,

AP1M2, RAB6, GIPC1, CD24A, RAB7, STX12,

CSE1L,

GO:0006350~transcription 6.35E-04 STAT5B, 2810021G02RIK, HOXD10, NKX6-3, 1772 13588 1.23228 0.869816 0.096917 1.145687

CREB3L2, D330038O06RIK, A130010J15RIK,

RARG, RXRB, ZHX1, ZFP467, MED11,

LOC100047209, PPARGC1B, SUV420H2, UHRF1,

RFC1, PIAS4, HES5, PRDM6, TGIF1, ZZZ3,

TGIF2, PIAS1, TRAPPC2, HOXA11, MYEF2, TADA1,

ARX, TAL2, HEXIM1,

GO:0019637~organophosphate metabolic process 7.06E-04 CHKA, PGS1, CDIPT, SGPP1, ABHD5, PTEN, PIGK, 176 13588 1.881604 0.896462 0.102364 1.273553

TPI1, LPCAT1, PLA2G12A, PCSK9, PITPNC1,

IP6K1, PIK3R1, PTDSS2, PIGA, GPD2, GPD1,

SPHK2, LPGAT1, NCF2, ALDH5A1, TAZ, PIK3CD,

PIGS, PIGO, MBOAT7, CD81, PLA2G4F, MBOAT2,

GYK, CLN8

GO:0033554~cellular response to stress 8.02E-04 HMGN1, MORF4L1, MMS19, XRCC4, ZMAT3, 404 13588 1.536953 0.923863 0.110464 1.44493

MORF4L2, 2310003H01RIK, FOXO3, FGF12,

PMAIP1, XRCC1, PRDX1, AQP2, OS9, MAP1LC3A,

2210018M11RIK, AEN, NSMCE1, PRMT6, FANCB,

RTEL1, CIB1, POLK, 1110054O05RIK, REV1, BRCC3, LIG3, UBE2B, ESCO2, JMY, CCND1,

UHRF1, RIF1, PSE

GO:0001764~neuron migration 8.46E-04 PRRXL1, SOX1, CAPZA2, PAX6, NR4A2, GJA1, 70 13588 2.513285 0.93398 0.111451 1.524321

PEX7, FEZF1, ARX, DAB1, PSEN1, NAV1, BAX,

MNX1, ALKBH1, TOP2B, APBB1

GO:0007155~cell adhesion 9.20E-04 MPZL3, NRP2, DLC1, CTNNAL1, CADM3, NRP1, 561 13588 1.438873 0.947828 0.115781 1.655257

MPZL2, CADM4, CADM1, LOC100046008, PCDHGA9,

PCDHGA8, PCDHGA7, L1CAM, PCDHGA6, PCDHGA5,

GM6212, PCDHGA4, PCDHGA3, PCDHGA2, PCDHGA1,

CDH22, CD47, CDC42, PCDHGB1, DAB1, CTGF,

VNN1, FERT2, PARD3B, SPON2, NEGR1, SPON1,

GO:0022610~biological adhesion 9.71E-04 MPZL3, NRP2, DLC1, CTNNAL1, CADM3, NRP1, 562 13588 1.436313 0.955819 0.117308 1.747623

MPZL2, CADM4, CADM1, LOC100046008, PCDHGA9,

PCDHGA8, PCDHGA7, L1CAM, PCDHGA6, PCDHGA5,

GM6212, PCDHGA4, PCDHGA3, PCDHGA2, PCDHGA1,

CDH22, CD47, CDC42, PCDHGB1, DAB1, CTGF,

VNN1, FERT2, PARD3B, SPON2, NEGR1, SPON1,

GO:0051493~regulation of organization 0.001092 XPO1, STMN3, MTAP2, CAPZA2, PSRC1, RICTOR, 99 13588 2.195204 0.970029 0.126201 1.962882

KANK3, NEXN, ACTR3, FMN1, CORO1A, SPNB2,

NPM1, CAPG, TMOD3, CLASP1, MTOR, MAPRE1,

CLASP2, STMN1-RS2, STMN1, MAP6D1

GO:0060284~regulation of cell development 0.001253 XRCC4, NOG, NRP1, HOXA11, BEX1, PAX6, SOX5, 159 13588 1.887521 0.982159 0.138535 2.249879

GM6212, TIMP2, CD24A, MUSK, TIAM1, VWC2,

SOCS2, NLGN1, SMAD2, ISL1, HDAC5, NTRK3,

SMO, YWHAH, HES5, PSEN1, BAX, NPTN, TGIF1,

TGIF2, WNT7A, NGF GO:0007162~negative regulation of cell adhesion 0.001786 ADAM10, DAB1, ATP5B, CBLL1, GM6212, PTEN, 25 13588 3.725575 0.996774 0.185256 3.19027

CD24A, PIK3R1, CML3

GO:0008219~cell death 0.002069 CADM1, SGPP1, ZMAT3, LRDD, TIMM50, PMAIP1, 507 13588 1.428831 0.998702 0.20483 3.686975

GM6212, PAWR, PDCD4, PTEN, SMNDC1, RTN3,

ACVR1C, CLPTM1L, CASP6, UNC5B, ANK2,

LOC623245, AEN, TIA1, TICAM1, NDUFS1, CIB1,

MYCS, CYCT, GM14138, GM6476, 4632434I11RIK,

GM11263, BCL2L13, BCL2L12, STK4, PURB, GZMF,

D

GO:0012501~programmed cell death 0.002172 CADM1, SGPP1, ZMAT3, LRDD, TIMM50, PMAIP1, 473 13588 1.444021 0.99907 0.207601 3.868565

GM6212, PAWR, PDCD4, PTEN, SMNDC1, RTN3,

ACVR1C, CLPTM1L, CASP6, UNC5B, ANK2,

LOC623245, AEN, TIA1, TICAM1, NDUFS1, CIB1,

MYCS, CYCT, GM14138, 4632434I11RIK,

GM11263, GM6476, BCL2L13, BCL2L12, STK4,

PURB, DAPK1,

GO:0016265~death 0.00243 CADM1, SGPP1, ZMAT3, LRDD, TIMM50, PMAIP1, 519 13588 1.415734 0.999595 0.222737 4.318779

GM6212, PAWR, PDCD4, PTEN, SMNDC1, RTN3,

ACVR1C, CLPTM1L, CASP6, UNC5B, ANK2,

LOC623245, AEN, TIA1, TICAM1, NDUFS1, CIB1,

MYCS, CYCT, GM14138, GM6476, GM11263,

4632434I11RIK, BCL2L13, BCL2L12, STK4,

PURB, GZMF, D

GO:0006281~DNA repair 0.002506 MMS19, HMGN1, MORF4L1, RAD23B, XRCC4, HMGB2, 222 13588 1.678187 0.999682 0.222491 4.449469

MGMT, MORF4L2, POLA1, 2310003H01RIK, XRCC1,

ERCC5, 2210018M11RIK, NSMCE1, PRMT6, RAD51L3, RTEL1, FANCB, TRIP13, POLK,

1110054O05RIK, BRCC3, RAD51AP1, REV1, SMC5,

LIG3, GM5521, UBE2B, ESCO2, JMY, RNF8,

UHRF1, PO

GO:0008104~protein localization 0.002583 XPO1, SRP14, CADM3, OXA1L, AP4E1, GRIK2, 753 13588 1.333115 0.999752 0.222419 4.583638

PMAIP1, TOMM20L, AIP, FAM125A, ANK2,

RABGEF1, GLE1, RAB27B, SAR1A, NUP133,

SRP54A, SRP54B, SGOL2, SRP54C, NUPL2, YIF1A,

NUPL1, TIMM8B, VTI1A, RAB19, LCA5, SRP72,

ERC1, AKAP2, ARL6IP1, 5430435G22RIK, RAB6,

GIPC1, LM

GO:0030182~neuron differentiation 0.002669 NRP1, AGTPBP1, PAX6, L1CAM, PAX3, JAG1, 399 13588 1.478403 0.999812 0.223042 4.733873

GM6212, PTEN, HOXD10, IGHMBP2, CDC42, NR2F6,

POU4F2, PAK1, TOP2B, TUBB3, PRRXL1, STMN3,

MTAP2, OTX2, KIF5C, STXBP1, SMO, PSEN1,

HES5, GNAQ, MIAT, MNX1, USH1C, STMN1, CLN8,

SOX1, SOX5, BRSK2, ABI2, CD24A, ARX, MTPN,

GO:0045597~positive regulation of cell differentiation 0.002692 XRCC4, HMGB1, HOXA11, CSF1, STAT5B, BEX1, 175 13588 1.774083 0.999825 0.219027 4.772612

PAX6, JAG1, FOXO3, ANKRD54, TIAM1, VNN1,

POU4F2, VWC2, RUNX1, HSP90AA1, SOCS2, SMAD2,

BAD, NTRK3, SMO, WNT7B, ID2, NPTN, MNDA,

TGIF1, TGIF2, GM15387, H2-DMA, NGF, IFI204

GO:0006325~chromatin organization 0.002882 ENY2, MORF4L1, HMGN1, HIST4H4, EZH1, 315 13588 1.54411 0.999905 0.226925 5.102027

GM10257, MORF4L2, NAP1L1, CBX2,

LOC100047441, CBX1, GM10094, SMARCD2,

H2AFV, 2210018M11RIK, PRMT8, PRMT6, H2AFZ, EED, H2AFY, KDM5C, BRD8, KDM5D, TBL1XR1,

BRCC3, HIST1H1C, HDAC10, LOC100045490,

H2AFJ, UBE2B, LOC10004720

GO:0033043~regulation of organelle organization 0.003355 XPO1, CAPZA2, ACTR3, MSX3, CDC42, SPNB2, 154 13588 1.814403 0.999979 0.252909 5.915047

NPM1, CLASP1, CLASP2, STMN3, MTAP2, PSRC1,

RICTOR, KANK3, NEXN, UBE2B, FMN1, CORO1A,

YWHAH, MAD2L1, CAPG, TMOD3, MTOR, MAPRE1,

STMN1-RS2, STMN1, NEK6, MAP6D1

GO:0042981~regulation of apoptosis 0.003451 XRCC4, GRIK2, STAT5B, FOXO3, PMAIP1, GM6212, 553 13588 1.384833 0.999985 0.253244 6.079025

ITSN1, PTEN, PRDX1, ACVR1C, LOC100046255,

CASP6, ANK2, LOC623245, B230120H23RIK, AEN,

TICAM1, VNN1, RARG, GM14138, GM6476,

GM11263, BCL2L13, CSDA, BCL2L12, UBE2B, JMY,

DAPK1, SMO, AGTR1B, PSEN1, GM4796, FOXC2,

GO:0006915~apoptosis 0.003514 CADM1, SGPP1, ZMAT3, LRDD, TIMM50, GM6212, 465 13588 1.424354 0.999988 0.25153 6.18652

PMAIP1, PAWR, PDCD4, PTEN, SMNDC1, RTN3,

ACVR1C, CLPTM1L, CASP6, UNC5B, ANK2,

LOC623245, AEN, TIA1, TICAM1, NDUFS1, CIB1,

MYCS, CYCT, GM14138, 4632434I11RIK,

GM11263, GM6476, BCL2L13, BCL2L12, STK4,

PURB, DAPK1,

GO:0016192~vesicle-mediated transport 0.00369 CLTA, AP4E1, LDLR, HIP1R, AP2S1, EPS15L1, 466 13588 1.421297 0.999993 0.256706 6.486827

ARHGAP17, GM6212, ITSN1, RTN3, CD47, CDC42,

CTTN, AP1S2, COPB1, RABGEF1, RAB6B, CAP1,

SEC24D, SAR1A, KDELR1, CLINT1, STX6, SEC23A,

LOC100048600, KIF17, LRP1B, STXBP1, ARHGAP27, YIF1A, TRIM36, GAPVD1, PSEN1,

OPHN1,

GO:0050767~regulation of neurogenesis 0.003747 XRCC4, NOG, NRP1, SOCS2, BEX1, PAX6, NLGN1, 132 13588 1.881604 0.999994 0.254659 6.583953

SOX5, GM6212, TIMP2, ISL1, CD24A, NTRK3,

SMO, YWHAH, PSEN1, HES5, TIAM1, NPTN, TGIF1,

VWC2, TGIF2, WNT7A, NGF

GO:0045664~regulation of neuron differentiation 0.003789 NRP1, SOCS2, PAX6, NLGN1, SOX5, BEX1, 102 13588 2.02918 0.999995 0.251837 6.655311

GM6212, TIMP2, ISL1, CD24A, NTRK3, YWHAH,

PSEN1, HES5, TIAM1, TGIF1, VWC2, TGIF2,

WNT7A, NGF

GO:0051960~regulation of nervous system development 0.003947 XRCC4, NOG, NRP1, BEX1, PAX6, SOX5, GM6212, 148 13588 1.818036 0.999997 0.255615 6.922831

TIMP2, CD24A, MUSK, TIAM1, VWC2, LHX5,

SOCS2, NLGN1, ISL1, NTRK3, SMO, YWHAH,

PSEN1, HES5, NPTN, TGIF1, TGIF2, WNT7A, NGF

GO:0007049~cell cycle 0.004184 MAEA, ANKRD54, LOC623245, B230120H23RIK, 611 13588 1.355001 0.999999 0.263502 7.323838

MAP3K8, PARD3B, CCNA2, MTUS1, ANAPC5,

GM5951, SGOL2, 4632434I11RIK, LIG3,

GM11263, PIM3, BOLL, VASH1, ESCO2, REC8,

UHRF1, MAD2L1, RCC2, LOC100044742, ZWINT,

STMN1, NEK4, NEK6, GM8783, EID1,

A730008H23RIK, CCNG1, SE

GO:0006613~cotranslational to membrane 0.004405 ARL6IP1, SRP14, SRP54A, SRPR, SRP54B, 8 13588 6.468012 0.999999 0.270134 7.69648

SRP54C, SRP72

GO:0044087~regulation of cellular component biogenesis 0.004596 CAPZA2, PSRC1, GM6212, RICTOR, KANK3, PTEN, 89 13588 2.09302 1 0.27493 8.01841

CD24A, ACTR3, FMN1, MUSK, CORO1A, SPNB2,

CAPG, TMOD3, MTOR, MAPRE1, STMN1-RS2, STMN1, WNT7A

GO:0043067~regulation of programmed cell death 0.004689 XRCC4, GRIK2, STAT5B, FOXO3, PMAIP1, GM6212, 560 13588 1.367523 1 0.274603 8.17438

ITSN1, PTEN, PRDX1, ACVR1C, LOC100046255,

CASP6, ANK2, LOC623245, B230120H23RIK, AEN,

TICAM1, VNN1, RARG, GM14138, GM6476,

GM11263, BCL2L13, CSDA, BCL2L12, UBE2B, JMY,

DAPK1, SMO, AGTR1B, PSEN1, GM4796, FOXC2,

GO:0015031~protein transport 0.004881 XPO1, SRP14, CLTA, AP4E1, GRIK2, ZMAT3, 651 13588 1.335332 1 0.279074 8.494451

AP2S1, VPS37C, TIMM50, NUP188, MITD1,

TOMM20L, PEX7, AIP, FAM125A, AP1S2, SRPR,

SEH1L, COPB1, GM2423, RABGEF1, RAB6B, GLE1,

GM14494, RAB27B, SEC24D, SAR1A, KDELR1,

STX6, SEC23A, NUP133, LOC100048600, SRP54A,

KIF17,

GO:0007507~heart development 0.004915 DLC1, NRP2, NRP1, FGF15, TBX20, GJA1, 223 13588 1.624254 1 0.275874 8.551436

FKBP1A, SOX6, PAX3, PTEN, GJA5,

LOC100046255, MSX2, ECE2, HEXIM1, PPP3CB,

MB, C2CD3, RXRB, SMAD7, TEAD1, SMAD2, MYH6,

ISL1, COL5A1, FOXP1, HDAC5, SMO, MURC,

PSEN1, ID2, GNAQ, FOXC2, NPPB, FOXC1, VCAN

GO:0010941~regulation of cell death 0.00527 XRCC4, GRIK2, STAT5B, FOXO3, PMAIP1, GM6212, 563 13588 1.360236 1 0.287678 9.141102

ITSN1, PTEN, PRDX1, ACVR1C, LOC100046255,

CASP6, ANK2, LOC623245, B230120H23RIK, AEN,

TICAM1, VNN1, RARG, GM14138, GM6476,

GM11263, BCL2L13, CSDA, BCL2L12, UBE2B, JMY,

DAPK1, SMO, AGTR1B, PSEN1, GM4796, FOXC2, GO:0010639~negative regulation of organelle organization 0.005557 MTAP2, CAPZA2, KANK3, UBE2B, MSX3, MAD2L1, 62 13588 2.33683 1 0.295831 9.615525

SPNB2, CAPG, TMOD3, CLASP1, STMN1-RS2,

STMN1, CLASP2, MAPRE1, MAP6D1

GO:0051674~localization of cell 0.00578 CER1, NRP2, NRP1, SOX1, FGF15, CAPZA2, 284 13588 1.530459 1 0.300809 9.98239

ATP5B, ASTN1, PAX6, GJA1, ABI2, GIPC1,

GM6212, PAX3, CD24A, PTEN, PEX7, ARX, DAB1,

CTGF, CLASP2, CAP1, TOP2B, PRRXL1, ARID5B,

NR4A2, DBH, ISL1, GAS8, FEZF1, SMO, CORO1A,

NUP62, NAV1, PSEN1, BAX, MNX1, FOXC1,

ALKBH1,

GO:0048870~cell motility 0.00578 CER1, NRP2, NRP1, SOX1, FGF15, CAPZA2, 284 13588 1.530459 1 0.300809 9.98239

ATP5B, ASTN1, PAX6, GJA1, ABI2, GIPC1,

GM6212, PAX3, CD24A, PTEN, PEX7, ARX, DAB1,

CTGF, CLASP2, CAP1, TOP2B, PRRXL1, ARID5B,

NR4A2, DBH, ISL1, GAS8, FEZF1, SMO, CORO1A,

NUP62, NAV1, PSEN1, BAX, MNX1, FOXC1,

ALKBH1,

GO:0045184~establishment of protein localization 0.005966 XPO1, SRP14, CLTA, AP4E1, GRIK2, ZMAT3, 656 13588 1.325154 1 0.304011 10.2877

AP2S1, VPS37C, TIMM50, NUP188, MITD1,

TOMM20L, PEX7, AIP, FAM125A, AP1S2, SRPR,

SEH1L, COPB1, GM2423, RABGEF1, RAB6B, GLE1,

GM14494, RAB27B, SEC24D, SAR1A, KDELR1,

STX6, SEC23A, NUP133, LOC100048600, SRP54A,

KIF17,

GO:0070507~regulation of microtubule cytoskeleton 0.006046 XPO1, MTAP2, CAPZA2, PSRC1, NPM1, CLASP1, 36 13588 2.874672 1 0.302685 10.41924 organization MAPRE1, STMN1, STMN1-RS2, CLASP2, MAP6D1 GO:0009890~negative regulation of biosynthetic process 0.006639 SRP14, CCDC85B, TBX20, NR6A1, PRRX1, CBX2, 434 13588 1.406867 1 0.32212 11.38367

PAX3, CBX1, PDCD4, CDT1, EIF4EBP3, INSIG2,

DYNLL1, TIA1, PRMT6, POU4F2, NFX1, TBL1XR1,

RARG, ZHX1, TLE1, IRF2BP2, UBE2B, PURB,

CTNNBIP1, PIAS4, HES5, PRDM6, TGIF1, CUX2,

NSD1, EID1, BCLAF1, HAT1, SOX6, ZBTB16, PA

GO:0035108~limb morphogenesis 0.006728 WNT5A, LMBR1, RARG, C2CD3, HOXA11, FTO, 115 13588 1.889784 1 0.320873 11.52676

PRRX1, GAS1, ZBTB16, KRTAP16-7, GJA5,

HOXD10, LOC100046255, MSX2, FMN1, ACD,

PSEN1, GNAQ, DLX6, BAX, HOXA9, WNT7A

GO:0035107~appendage morphogenesis 0.006728 WNT5A, LMBR1, RARG, C2CD3, HOXA11, FTO, 115 13588 1.889784 1 0.320873 11.52676

PRRX1, GAS1, ZBTB16, KRTAP16-7, GJA5,

HOXD10, LOC100046255, MSX2, FMN1, ACD,

PSEN1, GNAQ, DLX6, BAX, HOXA9, WNT7A

GO:0016568~chromatin modification 0.006775 MORF4L1, ENY2, ING5, EZH1, A730008H23RIK, 236 13588 1.578633 1 0.318087 11.60353

MORF4L2, HAT1, CBX2, LOC100047441, GM10094,

2210018M11RIK, SMARCD2, PRMT8, HJURP,

PRMT6, EED, H2AFY, TCF3, MYSM1, KDM5C,

KDM5D, BRD8, TBL1XR1, AEBP2, BRCC3, GM5521,

HDAC10, SMYD3, SAP18, UBE2B, LOC100047209,

HDAC5

GO:0010558~negative regulation of macromolecule 0.007176 SRP14, CCDC85B, TBX20, NR6A1, PRRX1, CBX2, 418 13588 1.411203 1 0.328724 12.24798 biosynthetic process PAX3, CBX1, PDCD4, CDT1, EIF4EBP3, TIA1,

PRMT6, POU4F2, NFX1, TBL1XR1, RARG, ZHX1,

TLE1, IRF2BP2, UBE2B, PURB, CTNNBIP1, PIAS4,

HES5, PRDM6, TGIF1, CUX2, NSD1, EID1, BCLAF1, HAT1, SOX6, ZBTB16, PAIP2B, MSX3,

HEXI

GO:0006644~phospholipid metabolic process 0.007218 CHKA, PGS1, CDIPT, SGPP1, ABHD5, PTEN, PIGK, 163 13588 1.714222 1 0.325726 12.31525

LPCAT1, PLA2G12A, PCSK9, PITPNC1, IP6K1,

PIK3R1, PIGA, PTDSS2, SPHK2, LPGAT1,

ALDH5A1, PIK3CD, TAZ, PIGS, PIGO, MBOAT7,

CD81, PLA2G4F, MBOAT2, CLN8

GO:0051129~negative regulation of cellular component 0.00725 NRP1, MTAP2, CAPZA2, KANK3, PTEN, UBE2B, 93 13588 2.002997 1 0.322468 12.36724 organization MSX3, YWHAH, MAD2L1, PSEN1, SPNB2, CAPG,

TMOD3, CLASP1, STMN1-RS2, STMN1, CLASP2,

MAPRE1, MAP6D1

GO:0051094~positive regulation of developmental process 0.008285 HMGB1, XRCC4, HOXA11, CSF1, STAT5B, BEX1, 214 13588 1.595846 1 0.354534 14.00929

PAX6, GJA1, JAG1, FOXO3, ANKRD54, TIAM1,

VNN1, POU4F2, VWC2, RUNX1, HSP90AA1, SOCS2,

SMAD2, BAD, NTRK3, SMO, WNT7B, ID2, BAX,

NPTN, MNDA, TGIF1, TGIF2, GM15387, H2-DMA,

WNT7A, NGF, IFI204

GO:0031327~negative regulation of cellular biosynthetic 0.008336 SRP14, CCDC85B, TBX20, NR6A1, PRRX1, CBX2, 430 13588 1.395887 1 0.351687 14.08942 process PAX3, CBX1, PDCD4, CDT1, EIF4EBP3, INSIG2,

DYNLL1, TIA1, PRMT6, POU4F2, NFX1, TBL1XR1,

RARG, ZHX1, TLE1, IRF2BP2, UBE2B, PURB,

CTNNBIP1, PIAS4, HES5, PRDM6, TGIF1, CUX2,

NSD1, EID1, BCLAF1, HAT1, SOX6, ZBTB16, PA

GO:0043254~regulation of protein complex assembly 0.008382 CAPZA2, PSRC1, RICTOR, GM6212, CD24A, ACTR3, 65 13588 2.228977 1 0.348779 14.16291

FMN1, CORO1A, SPNB2, CAPG, TMOD3, MTOR,

MAPRE1, STMN1-RS2, STMN1 GO:0045449~regulation of transcription 0.00869 STAT5B, 2810021G02RIK, HOXD10, NKX6-3, 2227 13588 1.147804 1 0.354512 14.64416

CREB3L2, TIGD5, CCNA2, D330038O06RIK,

A130010J15RIK, RARG, OBOX1, RXRB, OBOX2,

ZHX1, ZFP467, MED11, LOC100047209,

PPARGC1B, SUV420H2, UHRF1, RFC1, PIAS4,

HES5, PRDM6, TGIF1, ZZZ3, TGIF2, PIAS1,

TRAPPC2, NFKBID, HOXA1

GO:0030888~regulation of B cell proliferation 0.009456 CD38, CDKN1A, TICAM1, CD81, IGH-6, PAWR, 32 13588 2.910605 1 0.374505 15.83359

GM6212, CD24A, TCF3

GO:0021575~hindbrain morphogenesis 0.009795 DLC1, SMO, DAB1, AGTPBP1, MTPN, LHX5, GAS1, 26 13588 3.184252 1 0.380426 16.35378

WNT7A

GO:0048736~appendage development 0.009814 WNT5A, LMBR1, RARG, C2CD3, HOXA11, FTO, 119 13588 1.826262 1 0.376557 16.3829

PRRX1, GAS1, ZBTB16, KRTAP16-7, GJA5,

HOXD10, LOC100046255, MSX2, FMN1, ACD,

PSEN1, GNAQ, DLX6, BAX, HOXA9, WNT7A

GO:0060173~limb development 0.009814 WNT5A, LMBR1, RARG, C2CD3, HOXA11, FTO, 119 13588 1.826262 1 0.376557 16.3829

PRRX1, GAS1, ZBTB16, KRTAP16-7, GJA5,

HOXD10, LOC100046255, MSX2, FMN1, ACD,

PSEN1, GNAQ, DLX6, BAX, HOXA9, WNT7A

GO:0006457~ 0.009942 C80913, HSP90AA1, FKBP5, PPIL1, FKBP3, 127 13588 1.792709 1 0.37603 16.57882

FKBP1A, CCT3, LOC100047806, NKTR, AIP,

DNAJC17, TRAP1, HSP90B1, CLGN, PPIA, SLMAP,

CCT8L1, TOR1A, TOR1B, HSPE1, GM6257, H2-DMA,

PPWD1, HSPA8

GO:0010605~negative regulation of macromolecule metabolic 0.010067 NCBP2, SRP14, CCDC85B, TBX20, NR6A1, PRRX1, 506 13588 1.349846 1 0.375451 16.77081 process CBX2, PAX3, CBX1, PDCD4, CDT1, EIF4EBP3, TIA1, PRMT6, POU4F2, NFX1, TBL1XR1, RARG,

ZHX1, TLE1, IRF2BP2, UBE2B, PURB, TRAT1,

CTNNBIP1, PSEN1, PIAS4, HES5, PRDM6, ,

TGIF1, CUX2, NSD1, EID1, BCLAF1, HAT1, GIPC

GO:0030326~embryonic limb morphogenesis 0.01102 WNT5A, LMBR1, RARG, C2CD3, HOXA11, FTO, 97 13588 1.920399 1 0.398383 18.2114

PRRX1, GAS1, ZBTB16, GJA5, HOXD10, MSX2,

LOC100046255, ACD, PSEN1, GNAQ, DLX6, HOXA9,

WNT7A

GO:0035113~embryonic appendage morphogenesis 0.01102 WNT5A, LMBR1, RARG, C2CD3, HOXA11, FTO, 97 13588 1.920399 1 0.398383 18.2114

PRRX1, GAS1, ZBTB16, GJA5, HOXD10, MSX2,

LOC100046255, ACD, PSEN1, GNAQ, DLX6, HOXA9,

WNT7A

GO:0051172~negative regulation of nitrogen compound 0.011149 CCDC85B, NR6A1, TBX20, PRRX1, CBX2, CBX1, 401 13588 1.393607 1 0.397623 18.40463 metabolic process PAX3, PDCD4, CDT1, DYNLL1, PRMT6, POU4F2,

NFX1, TBL1XR1, RARG, ZHX1, TLE1, IRF2BP2,

UBE2B, PURB, CTNNBIP1, PIAS4, HES5, PRDM6,

TGIF1, RAD18, CUX2, NSD1, EID1, BCLAF1,

HAT1, SOX6, ZBTB16, MSX3, HEXIM1, ZKSCAN17,

LA

GO:0045934~negative regulation of nucleobase, nucleoside, 0.014013 CCDC85B, NR6A1, TBX20, PRRX1, CBX2, CBX1, 397 13588 1.38158 1 0.466956 22.58752 nucleotide and nucleic acid metabolic process PAX3, PDCD4, CDT1, PRMT6, POU4F2, NFX1,

TBL1XR1, RARG, ZHX1, TLE1, IRF2BP2, UBE2B,

PURB, CTNNBIP1, PIAS4, HES5, PRDM6, TGIF1,

RAD18, CUX2, NSD1, EID1, BCLAF1, HAT1, SOX6,

ZBTB16, MSX3, HEXIM1, ZKSCAN17, LANCL2, NP

GO:0006614~SRP-dependent cotranslational protein 0.014363 SRP14, SRP54A, SRPR, SRP54B, SRP54C, SRP72 6 13588 6.899213 1 0.470689 23.08565 targeting to membrane

GO:0031111~negative regulation of microtubule 0.014696 MTAP2, CLASP1, MAPRE1, STMN1, STMN1-RS2, 16 13588 3.880807 1 0.473885 23.55557 polymerization or depolymerization CLASP2, MAP6D1

GO:0051494~negative regulation of cytoskeleton 0.014798 MTAP2, SPNB2, CAPZA2, CAPG, TMOD3, CLASP1, 48 13588 2.371604 1 0.471705 23.69893 organization MAPRE1, STMN1, STMN1-RS2, CLASP2, KANK3,

MAP6D1

GO:0031110~regulation of microtubule polymerization or 0.014877 MTAP2, CAPZA2, PSRC1, CLASP1, MAPRE1, STMN1, 28 13588 2.956806 1 0.469035 23.80877 depolymerization STMN1-RS2, CLASP2, MAP6D1

GO:0016481~negative regulation of transcription 0.01528 CCDC85B, NR6A1, TBX20, PRRX1, CBX2, CBX1, 372 13588 1.39097 1 0.473709 24.3725

PAX3, PDCD4, PRMT6, POU4F2, NFX1, TBL1XR1,

RARG, ZHX1, TLE1, IRF2BP2, UBE2B, PURB,

CTNNBIP1, PIAS4, HES5, PRDM6, TGIF1, CUX2,

NSD1, EID1, BCLAF1, HAT1, ZBTB16, SOX6,

MSX3, HEXIM1, ZKSCAN17, LANCL2, POU2F1,

PER3, S

GO:0006612~protein targeting to membrane 0.015433 ARL6IP1, SRP14, SRP54A, SRPR, SRP54B, 22 13588 3.292806 1 0.47276 24.58647

SRP54C, DNHD1, SRP72, TIMM8B

GO:0021587~cerebellum morphogenesis 0.015433 SMO, DAB1, AGTPBP1, MTPN, LHX5, GAS1, WNT7A 22 13588 3.292806 1 0.47276 24.58647

GO:0006928~cell motion 0.018119 NRP2, NRP1, FGF15, CAPZA2, ATP5B, PAX6, 367 13588 1.381722 1 0.524297 28.23181

GJA1, L1CAM, GM6212, PAX3, PTEN, PEX7, DAB1,

CTGF, POU4F2, CAP1, TOP2B, PRRXL1, ARID5B,

KIF5C, SMO, PSEN1, NAV1, MNX1, FOXC1, CER1,

SOX1, ASTN1, ABI2, GIPC1, CD24A, ARX, LHX2,

CLASP2, B3GNT2, NR4A2, GAS1, DBH, ISL1,

GO:0007050~cell cycle arrest 0.018969 CDKN1A, AK1, 4632434I11RIK, GAS2L2, 57 13588 2.178699 1 0.536265 29.35117

TRP53INP1, GAS1, SKIL, SESN2, APBB1, VASH1, SESN3, JMY

GO:0032271~regulation of protein polymerization 0.018969 CAPZA2, PSRC1, RICTOR, ACTR3, FMN1, CORO1A, 57 13588 2.178699 1 0.536265 29.35117

SPNB2, CAPG, TMOD3, STMN1-RS2, STMN1,

MAPRE1, MTOR

GO:0051276~ organization 0.019143 HMGN1, MORF4L1, ENY2, HIST4H4, EZH1, 404 13588 1.357642 1 0.535132 29.57872

MORF4L2, GM10257, NAP1L1, CBX2, CBX1,

LOC100047441, GM10094, SMARCD2, H2AFV,

2210018M11RIK, PRMT8, SEH1L, PRMT6, EED,

H2AFZ, H2AFY, KDM5C, RTEL1, KDM5D, BRD8,

TBL1XR1, BRCC3, HIST1H1C, SGOL2, HDAC10,

LOC100045490, H2AF

GO:0046164~alcohol catabolic process 0.020434 ALDOA, ALDOART1, GPD1, LDHAL6B, PGD, DLAT, 65 13588 2.069764 1 0.554337 31.24066

BAD, DBH, GPI1, TPI1, PGLS, PGK1, GAPDH

GO:0010648~negative regulation of cell communication 0.020654 CER1, NOG, GNAI2, NFKBID, GRIK2, PAWR, PTEN, 186 13588 1.557887 1 0.553881 31.52116

SLC24A2, VWC2, DDIT4L, SKIL, PHLDA3, STMN3,

SOCS2, STXBP1, GAS1, CISH, CTNNBIP1, CYP7B1,

RGS20, CCND1, SOST, NUP62, ACAP1, RGS6,

TGIF1, TNK1, MTOR

GO:0042325~regulation of phosphorylation 0.020949 HMGB1, GNAI2, CSF1, LPAR3, FKBP1A, GM6212, 290 13588 1.427423 1 0.554713 31.89322

PDCD4, CD24A, APLP2, TRIB1, CDC42, ANKRD54,

DAB1, DGKD, HEXIM1, DGKG, NPM1, DUSP16,

PDGFD, PPP1R14C, PPP1R14B, PPP1R14A, SPHK2,

SPHK1, STRADA, IGH-6, RICTOR, UBE2B, CISH,

ACVR2A, CDKN1A, ARRB2, NUP62, PSEN1, BAX,

GO:0002260~lymphocyte homeostasis 0.021598 GM8779, STAT5B, GM14138, PIK3CD, GM11263, 30 13588 2.759685 1 0.561585 32.70861

GM6476, RPS6, LOC639593, GM16409, CORO1A, GM13654, LOC623245, LILRB3, BAX, PPP3CB,

GM4796, SKIL

GO:0045637~regulation of myeloid cell differentiation 0.02223 HMGB1, ANKRD54, ID2, CSF1, STAT5B, FOXO3, 51 13588 2.232098 1 0.567903 33.49241

JAG1, ZBTB16, GM15387, RUNX1, CLEC2G, PIK3R1

GO:0016052~carbohydrate catabolic process 0.02225 ALDOA, ALDOART1, GPD1, HYAL2, LDHAL6B, PGD, 81 13588 1.916448 1 0.564039 33.51663

CHI3L1, DLAT, BAD, GPI1, AKR1A4, PGLS, TPI1,

PGK1, GAPDH

GO:0046486~glycerolipid metabolic process 0.02259 CHKA, ALDH5A1, PIK3CD, ABHD5, TAZ, PNPLA2, 129 13588 1.684692 1 0.565461 33.93531

PIGS, PTEN, PNPLA3, PIGO, APOB48R, PIGK,

INSIG2, DGKD, CD81, PCSK9, PITPNC1, IP6K1,

PIK3R1, PIGA, PTDSS2

GO:0070230~positive regulation of lymphocyte apoptosis 0.023348 NFKBID, BAX, GM6212, CD24A 7 13588 5.913611 1 0.573477 34.8588

GO:0051253~negative regulation of RNA metabolic process 0.023397 EID1, TBX20, NR6A1, PRRX1, HAT1, CBX2, SOX6, 310 13588 1.402098 1 0.570182 34.91747

ZBTB16, PAX3, CBX1, MSX3, HEXIM1, ZKSCAN17,

PRMT6, NPM1, POU4F2, PER3, SKIL, TCF25,

NFX1, ETV3, TBL1XR1, RARG, KLF12, ZHX1,

TRIM27, IRF2BP2, TLE1, TRIM24, WWTR1, UBE2B,

PURB, FOXP1, CTNNBIP1, HDAC5, HES5, PIAS4

GO:0031334~positive regulation of protein complex assembly 0.023585 FMN1, CAPZA2, PSRC1, MTOR, RICTOR, GM6212, 24 13588 3.018406 1 0.569111 35.14435

CD24A

GO:0007264~small GTPase mediated signal transduction 0.024563 CTNNAL1, 5430435G22RIK, GRB2, ARFRP1, RAB6, 258 13588 1.444021 1 0.580102 36.31365

ITSN1, 4933421I07RIK, RAB7, CDC42, ARL5A,

DAB1, DIRAS2, TIAM1, SOS1, GM2423, RRAS,

RALA, RAB6B, CDC42EP4, RAB27B, ARL5B, RHOG,

RHOH, RAP2B, ARL1, RAP2C, BAIAP2, PSD3,

TRIM23, ARL6, RND3, MURC, ARF1, RAB19, YWHAQ GO:0019320~hexose catabolic process 0.025221 ALDOA, ALDOART1, PGLS, TPI1, LDHAL6B, PGD, 52 13588 2.189173 1 0.585923 37.0885

DLAT, BAD, PGK1, GAPDH, GPI1

GO:0006007~glucose catabolic process 0.025221 ALDOA, ALDOART1, PGLS, TPI1, LDHAL6B, PGD, 52 13588 2.189173 1 0.585923 37.0885

DLAT, BAD, PGK1, GAPDH, GPI1

GO:0007242~intracellular signaling cascade 0.025782 CTNNAL1, STAT5B, LPAR3, TNFSF14, FGF12, 915 13588 1.21019 1 0.590153 37.7418

ITSN1, DIRAS2, DAB1, CTGF, TIAM1,

B230120H23RIK, RRAS, RALA, RAB27B, EDARADD,

DEPDC6, RARG, SOCS2, BRAF, STMN3, RXRB,

STMN2, BAIAP2, PIK3CD, PSD3, NTSR2, MARK1,

PPARGC1B, RND3, MAP4K5, SSTR2, PIAS4, RAB19,

ACAP1, CA

GO:0032886~regulation of microtubule-based process 0.026007 XPO1, MTAP2, CAPZA2, PSRC1, NPM1, CLASP1, 45 13588 2.299738 1 0.589512 38.00288

MAPRE1, STMN1, STMN1-RS2, CLASP2, MAP6D1

GO:0006259~DNA metabolic process 0.026819 MMS19, MORF4L1, HMGN1, XRCC4, MORF4L2, 421 13588 1.327402 1 0.597068 38.93282

2310003H01RIK, XRCC1, CDT1, DNASE1L1,

2210018M11RIK, ORC4L, CTGF, NSMCE1, PRMT6,

TOP2B, FANCB, RTEL1, POLK, 1110054O05RIK,

REV1, BRCC3, LIG3, MCM3, UBE2B, MBD1, ESCO2,

PURB, ORC1L, JMY, UHRF1, RFC4, RFC1,

LOC10004439

GO:0008654~phospholipid biosynthetic process 0.02698 CHKA, CDIPT, PGS1, LPGAT1, SPHK2, ABHD5, 83 13588 1.870269 1 0.595502 39.1164

PIGS, PIGO, PIGK, LPCAT1, MBOAT7, CD81,

MBOAT2, PTDSS2, PIGA

GO:0044275~cellular carbohydrate catabolic process 0.027052 ALDOA, ALDOART1, GPD1, PGLS, TPI1, LDHAL6B, 60 13588 2.069764 1 0.592736 39.19794

PGD, DLAT, BAD, PGK1, GAPDH, GPI1

GO:0051338~regulation of activity 0.02711 GNAI2, CSF1, LPAR3, CD24A, PDCD4, APLP2, 199 13588 1.508119 1 0.589823 39.26414 TRIB1, CDC42, ANKRD54, DAB1, HEXIM1, DGKD,

DGKG, NPM1, DUSP16, SPHK2, SPHK1, STRADA,

IGH-6, CISH, CDKN1A, NUP62, PSEN1, CD81,

MAPK8IP3, FABP4, LRP8, MTOR, CLN8

GO:0045639~positive regulation of myeloid cell 0.028571 HMGB1, ANKRD54, ID2, CSF1, FOXO3, JAG1, 25 13588 2.897669 1 0.605638 40.89741 differentiation GM15387, RUNX1

GO:0043549~regulation of activity 0.029768 GNAI2, CSF1, LPAR3, CD24A, PDCD4, APLP2, 192 13588 1.509203 1 0.617287 42.20514

TRIB1, CDC42, ANKRD54, DAB1, HEXIM1, DGKD,

DGKG, NPM1, DUSP16, SPHK2, SPHK1, STRADA,

IGH-6, CISH, CDKN1A, NUP62, PSEN1, CD81,

MAPK8IP3, FABP4, LRP8, MTOR

GO:0016570~histone modification 0.029792 MORF4L1, ING5, BRCC3, HDAC10, HAT1, UBE2B, 92 13588 1.799795 1 0.613969 42.23126

RNF8, SUV420H2, PRMT8, PRMT6, EED, FTSJD2,

APBB1, TCF3, NSD1, MYSM1, BRD8

GO:0006605~protein targeting 0.030315 ARL6IP1, SRP14, XPO1, GIPC1, TOMM20L, AIP, 133 13588 1.634024 1 0.61687 42.79293

PEX7, CSE1L, SRPR, SPNB2, GM2423, GM14494,

NUP54, TNPO2, LOC100044630, TNPO1, SRP54A,

SRP54B, SRP54C, STRADA, DNHD1, TIMM8B,

6230409E13RIK, TOMM20, YWHAQ, SRP72

GO:0043603~cellular amide metabolic process 0.030339 PGLS, TPI1, NCF2, ARG2, OTC, PGD, STAT5B, 39 13588 2.388189 1 0.613621 42.81918

NADSYN1, DCXR

GO:0046365~monosaccharide catabolic process 0.03205 ALDOA, ALDOART1, PGLS, TPI1, LDHAL6B, PGD, 54 13588 2.108093 1 0.630592 44.62169

DLAT, BAD, PGK1, GAPDH, GPI1

GO:0016125~sterol metabolic process 0.032076 SREBF1, SC5D, HDLBP, MVD, LDLR, LEPR, PCTP, 77 13588 1.881604 1 0.627407 44.64852

APOB48R, CYP7B1, INSIG2, PCSK9, PRKAA1,

CLN8, CLN6 GO:0045892~negative regulation of transcription, 0.032296 EID1, TBX20, NR6A1, PRRX1, HAT1, CBX2, SOX6, 308 13588 1.377603 1 0.626512 44.87667

DNA-dependent ZBTB16, PAX3, CBX1, MSX3, HEXIM1, ZKSCAN17,

PRMT6, POU4F2, PER3, SKIL, TCF25, NFX1,

ETV3, TBL1XR1, RARG, KLF12, ZHX1, TRIM27,

IRF2BP2, TLE1, TRIM24, WWTR1, UBE2B, PURB,

FOXP1, CTNNBIP1, HDAC5, HES5, PIAS4, ID2,

GO:0007010~cytoskeleton organization 0.0323 DLC1, PRKCZ, MAEA, CNN3, CAPZA2, ARHGAP17, 326 13588 1.365028 1 0.623143 44.88128

FHDC1, PFN2, TUBGCP5, SEH1L, B230120H23RIK,

NPM1, TUBB5, PALM2, LOC100047856, CAP1,

EHD2, RHOG, CAP2, STMN3, MTAP2, PSRC1, MYH6,

RICTOR, RACGAP1, UBE2B, MARK1, FMN1, SS18,

EPB4.1L3, MURC, CORO1A, PPP1R9A, MAST1,

GO:0010720~positive regulation of cell development 0.033654 NTRK3, SMO, XRCC4, TIAM1, HOXA11, NPTN, 47 13588 2.201876 1 0.635113 46.26373

PAX6, BEX1, SMAD2, NGF

GO:0045859~regulation of activity 0.034657 GNAI2, CSF1, LPAR3, CD24A, PDCD4, APLP2, 186 13588 1.502248 1 0.642746 47.26673

TRIB1, ANKRD54, DAB1, HEXIM1, DGKD, DGKG,

NPM1, DUSP16, SPHK2, SPHK1, STRADA, IGH-6,

CISH, CDKN1A, PSEN1, NUP62, CD81, MAPK8IP3,

FABP4, LRP8, MTOR

GO:0008203~cholesterol metabolic process 0.034672 SREBF1, HDLBP, MVD, LDLR, LEPR, PCTP, 70 13588 1.921924 1 0.639578 47.28143

APOB48R, CYP7B1, INSIG2, PCSK9, PRKAA1,

CLN8, CLN6

GO:0009083~branched chain family amino acid catabolic 0.034714 BCKDK, BCAT2, ACAD8, AUH 8 13588 5.17441 1 0.63673 47.32281 process

GO:0051174~regulation of phosphorus metabolic process 0.035246 HMGB1, GNAI2, CSF1, LPAR3, FKBP1A, GM6212, 301 13588 1.375258 1 0.639155 47.84694

PDCD4, CD24A, APLP2, TRIB1, CDC42, ANKRD54, DAB1, DGKD, HEXIM1, DGKG, NPM1, DUSP16,

PDGFD, PPP1R14C, PPP1R14B, PPP1R14A, SPHK2,

SPHK1, STRADA, IGH-6, RICTOR, UBE2B, CISH,

ACVR2A, CDKN1A, ARRB2, NUP62, PSEN1, BAX,

GO:0019220~regulation of phosphate metabolic process 0.035246 HMGB1, GNAI2, CSF1, LPAR3, FKBP1A, GM6212, 301 13588 1.375258 1 0.639155 47.84694

PDCD4, CD24A, APLP2, TRIB1, CDC42, ANKRD54,

DAB1, DGKD, HEXIM1, DGKG, NPM1, DUSP16,

PDGFD, PPP1R14C, PPP1R14B, PPP1R14A, SPHK2,

SPHK1, STRADA, IGH-6, RICTOR, UBE2B, CISH,

ACVR2A, CDKN1A, ARRB2, NUP62, PSEN1, BAX,

GO:0030030~cell projection organization 0.035308 NRP1, PAX6, LPAR3, ABI2, L1CAM, GM6212, 319 13588 1.36254 1 0.636576 47.90811

CD24A, PTEN, ARX, CDC42, IFT20, LHX2,

POU4F2, PAK1, B3GNT2, TOP2B, FGD3, PRRXL1,

C2CD3, STMN3, MTAP2, MCF2, BAIAP2, KIF5C,

RTN4R, STXBP1, NR4A2, GAS1, WWTR1, ISL1,

UBE2B, WHRN, FEZF1, CORO1A, PPP1R9A, CAPG,

MNX1, MA

GO:0030155~regulation of cell adhesion 0.035323 ADAM10, CSF1, ATP5B, STAT5B, L1CAM, GM6212, 94 13588 1.761501 1 0.633516 47.92218

CBLL1, ECM2, PTEN, CD24A, DAB1, LOC640441,

FBLN2, VWC2, THBS1, CML3, PIK3R1

GO:0010629~negative regulation of expression 0.035415 NCBP2, CCDC85B, NR6A1, TBX20, PRRX1, CBX2, 410 13588 1.312533 1 0.631308 48.01248

CBX1, PAX3, PDCD4, PRMT6, POU4F2, NFX1,

TBL1XR1, RARG, ZHX1, TLE1, IRF2BP2, UBE2B,

PURB, CTNNBIP1, PIAS4, HES5, PRDM6, TGIF1,

CUX2, NSD1, EID1, BCLAF1, HAT1, SOX6,

ZBTB16, MSX3, HEXIM1, ZKSCAN17, LANCL2, POU2F1,

GO:0050864~regulation of B cell activation 0.03591 CD38, CDKN1A, TICAM1, STAT5B, CD81, IGH-6, 55 13588 2.069764 1 0.633351 48.49441

PAWR, GM6212, BAD, CD24A, TCF3

GO:0032535~regulation of cellular component size 0.036267 NRP1, CCDC85B, CAPZA2, ZMAT3, PSRC1, RICTOR, 161 13588 1.542681 1 0.633928 48.83947

NTRK3, ACTR3, FMN1, CORO1A, EI24, ACAP1,

SPNB2, CD81, NPM1, CAPG, POU4F2, TMOD3,

TNK1, MTOR, WNT7A, CLN8, APBB1, NGF

GO:0021522~spinal cord motor neuron differentiation 0.03778 IGHMBP2, MNX1, PAX6, ISL1, CLN8, HOXD10 20 13588 3.104646 1 0.646138 50.27668

GO:0009791~post- 0.0386 HMGN1, ALDH5A1, ARID5B, NR4A2, SMAD2, 87 13588 1.784279 1 0.651111 51.04006

KRTAP16-7, SOX6, TET2, TAL2, PSEN1, GNAQ,

BAX, LOC100044391, SCN9A, MNX1, MAPK8IP3

GO:0070228~regulation of lymphocyte apoptosis 0.039397 NFKBID, BAX, GM6212, PTEN, CD24A 14 13588 3.696007 1 0.655717 51.7709

GO:0048339~paraxial development 0.039397 NUP133, FOXC2, FOXC1, SMAD2, EPB4.1L5 14 13588 3.696007 1 0.655717 51.7709

GO:0006739~NADP metabolic process 0.039397 PGLS, TPI1, NCF2, PGD, DCXR 14 13588 3.696007 1 0.655717 51.7709

GO:0051168~nuclear export 0.040506 NCBP2, NUP133, XPO1, GM5643, NPM1, STRADA, 27 13588 2.683027 1 0.6631 52.77192

GLE1, HNRNPA1

GO:0009953~dorsal/ventral pattern formation 0.041336 SMO, PSEN1, DISP1, HOXA11, LHX2, TBX20, 64 13588 1.940404 1 0.667698 53.50772

OTX2, MNX1, PAX6, TGIF1, GAS1, WNT7A

GO:0016569~covalent chromatin modification 0.041561 MORF4L1, ING5, BRCC3, HDAC10, HAT1, UBE2B, 96 13588 1.724803 1 0.666755 53.70444

RNF8, SUV420H2, PRMT8, PRMT6, EED, FTSJD2,

APBB1, TCF3, NSD1, MYSM1, BRD8

GO:0006650~glycerophospholipid metabolic process 0.04199 CHKA, ALDH5A1, PIK3CD, ABHD5, TAZ, PIGS, 88 13588 1.764003 1 0.66766 54.07942

PTEN, PIGO, PIGK, CD81, PITPNC1, IP6K1,

PIK3R1, PTDSS2, PIGA

GO:0046578~regulation of Ras protein signal transduction 0.042688 AGFG2, CSF1, AKAP13, ITSN1, PLEKHG4, 181 13588 1.486571 1 0.670907 54.68233

TBC1D12, TIAM1, SOS1, GIT2, FGD3, IQSEC1, TBC1D9B, STMN3, MCF2, PSD3, ARHGAP27,

RICTOR, ARHGEF12, ECT2, SGSM1, NUP62, ACAP1,

TNK1, MTOR, ARAP2, SPATA13

GO:0048872~homeostasis of number of cells 0.043194 MAEA, CSF1, STAT5B, ILDR2, SOX6, PRDX1, 113 13588 1.648485 1 0.672427 55.11553

GM16409, LOC623245, PPP3CB, DYRK3, SKIL, MB,

GM8779, PIK3CD, GM14138, GM11263, GM6476,

RPS6, LOC639593, CORO1A, GM13654, RPS19,

ID2, LILRB3, BAX, GM4796, ADD1

GO:0030510~regulation of BMP signaling pathway 0.045774 CER1, ACVR2A, NOG, SOST, KCP, VWC2 21 13588 2.956806 1 0.691186 57.26061

GO:0043242~negative regulation of protein complex 0.046894 MTAP2, SPNB2, CAPZA2, CAPG, TMOD3, CLASP1, 35 13588 2.365444 1 0.697342 58.16219 disassembly CLASP2, MAP6D1

GO:0031175~neuron projection development 0.047174 NRP1, PAX6, ABI2, L1CAM, GM6212, CD24A, 218 13588 1.424149 1 0.696751 58.38421

PTEN, ARX, LHX2, POU4F2, PAK1, B3GNT2,

TOP2B, PRRXL1, STMN3, MCF2, MTAP2, KIF5C,

RTN4R, STXBP1, NR4A2, GAS1, ISL1, FEZF1,

PPP1R9A, MNX1, MAPK8IP3, ALKBH1, STMN1-RS2,

STMN1, APBB1

GO:0032946~positive regulation of mononuclear cell 0.047822 CD38, CDKN1A, CORO1A, TICAM1, STAT5B, CD81, 50 13588 2.069764 1 0.699038 58.895 proliferation IGH-6, GM6212, CD24A, TCF3

GO:0050671~positive regulation of lymphocyte 0.047822 CD38, CDKN1A, CORO1A, TICAM1, STAT5B, CD81, 50 13588 2.069764 1 0.699038 58.895 proliferation IGH-6, GM6212, CD24A, TCF3

GO:0002902~regulation of B cell apoptosis 0.048408 BAX, GM6212, PTEN, CD24A 9 13588 4.599475 1 0.700799 59.35139

GO:0033002~muscle cell proliferation 0.048408 RXRB, FOXC2, FOXC1, NAA35 9 13588 4.599475 1 0.700799 59.35139

GO:0045047~protein targeting to ER 0.048408 SRP14, SRP54A, SRPR, SRP54B, SRP54C, SRP72 9 13588 4.599475 1 0.700799 59.35139

GO:0032314~regulation of Rac GTPase activity 0.048973 STMN3, MTOR, RICTOR 4 13588 7.761615 1 0.702367 59.78676

GO:0002327~immature B cell differentiation 0.048973 GM6212, CD24A, FOXP1 4 13588 7.761615 1 0.702367 59.78676 GO:0002329~pre-B cell differentiation 0.048973 GM6212, CD24A, FOXP1 4 13588 7.761615 1 0.702367 59.78676

GO:0009081~branched chain family amino acid metabolic 0.049737 BCKDK, BCAT2, STAT5B, ACAD8, AUH 15 13588 3.449606 1 0.705395 60.36933 process

GO:0003007~heart morphogenesis 0.050291 DLC1, C2CD3, SMAD7, TBX20, GJA1, FKBP1A, 74 13588 1.818036 1 0.706809 60.78633

ISL1, COL5A1, MSX2, LOC100046255, SMO,

PSEN1, FOXC2, FOXC1

GO:0040007~growth 0.050907 WNT5A, HOXA11, CSF1, GJA1, FOXO3, KRTAP16-7, 193 13588 1.447762 1 0.708647 61.24518

PTEN, GJC3, ACVR1C, TAL2, ERCC5, SAFB, MTPN,

NPM1, APBA2, POU4F2, GINS1, RXRB, ARID5B,

SMAD2, GAS1, SMO, PSEN1, FOXC2, FOXC1,

ALKBH1, ADD1

GO:0043244~regulation of protein complex disassembly 0.050917 MTAP2, SPNB2, CAPZA2, CAPG, TMOD3, CLASP1, 43 13588 2.166032 1 0.706086 61.25269

CLASP2, PTMS, MAP6D1

GO:0048666~neuron development 0.052128 NRP1, SOX1, PAX6, ABI2, L1CAM, GM6212, 292 13588 1.346764 1 0.71214 62.13946

CD24A, PTEN, HOXD10, ARX, LHX2, NR2F6,

POU4F2, B3GNT2, PAK1, TOP2B, RUNX1, PRRXL1,

STMN3, MTAP2, MCF2, KIF5C, RTN4R, STXBP1,

NR4A2, GAS1, ISL1, WHRN, FEZF1, PPP1R9A,

GNAQ, PSEN1, MIAT, MNX1, MAPK8IP3, ALKBH1,

STMN1,

GO:0030029~actin filament-based process 0.052436 DLC1, CNN3, CAPZA2, ARHGAP17, FHDC1, PFN2, 176 13588 1.470003 1 0.711723 62.36223

PALM2, LOC100047856, CAP1, EHD2, RHOG,

RICTOR, MYH6, RACGAP1, FLNC, FMN1, MURC,

EPB4.1L3, PPP1R9A, CORO1A, NRAP, EPB4.1,

OPHN1, USH1C, APBB1, AKAP2, CDC42BPB

GO:0008284~positive regulation of cell proliferation 0.05454 HMGB1, XRCC4, NOG, CNBP, GNAI2, FGF15, 284 13588 1.348262 1 0.723601 63.84969 MARCKSL1, CSF1, STAT5B, BEX1, PRRX1, PAX6,

GM6212, PAX3, CD24A, NPM1, TICAM1, LHX5,

TCF3, NACC1, CCKBR, SPHK2, SPHK1, BIRC6,

IGH-6, GAS1, FOXP1, CD38, SMO, CYP7B1,

CDKN1A, CORO1A, DLX6, TIAL1, CD81, TGIF1,

FABP4, GM1

GO:0007157~heterophilic cell adhesion 0.054697 CADM3, CADM1, L1CAM, GM6212, MCAM, CD24A 22 13588 2.822405 1 0.722125 63.95883

GO:0030890~positive regulation of B cell proliferation 0.054697 CD38, CDKN1A, TICAM1, CD81, IGH-6, TCF3 22 13588 2.822405 1 0.722125 63.95883

GO:0048589~developmental growth 0.056312 WNT5A, GINS1, CSF1, HOXA11, GJA1, SMAD2, 100 13588 1.655811 1 0.730235 65.05936

FOXO3, GAS1, KRTAP16-7, PTEN, ACVR1C, SMO,

PSEN1, MTPN, POU4F2, ALKBH1

GO:0006730~one-carbon metabolic process 0.056976 MAT2A, LCMT2, LOC676792, RAB6, UBE2B, MBD1, 117 13588 1.592126 1 0.732022 65.50292

PRMT3, MTHFD1, SUV420H2, RNF8, MTHFD2, DHFR,

PRMT8, PRMT6, CAR8, EED, FTSJD2, AHCYL1,

FTSJ1, NSD1

GO:0070665~positive regulation of leukocyte proliferation 0.059184 CD38, CDKN1A, CORO1A, TICAM1, STAT5B, CD81, 52 13588 1.990158 1 0.743333 66.93965

IGH-6, GM6212, CD24A, TCF3

GO:0048598~embryonic morphogenesis 0.059308 DLC1, NOG, LMO4, PRRX1, PAX3, GJA5, HOXD10, 359 13588 1.297206 1 0.741666 67.01828

ZIC2, LOC100046255, INSIG2, LOC623245,

ODZ4, RARG, C2CD3, GM14138, OTX2, GM11263,

GM6476, ACVR2A, PSEN1, GNAQ, TGIF1, FOXC2,

GM4796, USH1C, FOXC1, EXT1, NSD1, CER1,

WNT5A, LMBR1, GRB2, HOXA11, ARFRP1, PTK7,

ZBTB

GO:0050871~positive regulation of B cell activation 0.060786 CD38, CDKN1A, TICAM1, STAT5B, CD81, IGH-6, 37 13588 2.237583 1 0.74812 67.94588

BAD, TCF3 GO:0035050~embryonic heart tube development 0.061418 TBX20, GJA1, FOXC2, FOXC1, GJA5 16 13588 3.234006 1 0.749454 68.3347

GO:0010324~membrane invagination 0.061996 STON2, ABCA7, LDLR, GULP1, HIP1R, EPS15L1, 188 13588 1.43122 1 0.750458 68.68678

GM6212, ITSN1, CD24A, CD47, CTTN, AP1S2,

RABGEF1, CAP1, CLINT1, EHD2, HIP1, LRP1B,

STXBP1, ARHGAP27, AP2A2, GAPVD1, OPHN1,

LRP8, STEAP2, DNM2

GO:0006897~endocytosis 0.061996 STON2, ABCA7, LDLR, GULP1, HIP1R, EPS15L1, 188 13588 1.43122 1 0.750458 68.68678

GM6212, ITSN1, CD24A, CD47, CTTN, AP1S2,

RABGEF1, CAP1, CLINT1, EHD2, HIP1, LRP1B,

STXBP1, ARHGAP27, AP2A2, GAPVD1, OPHN1,

LRP8, STEAP2, DNM2

GO:0030833~regulation of actin filament polymerization 0.063933 FMN1, ACTR3, CORO1A, SPNB2, CAPZA2, CAPG, 45 13588 2.069764 1 0.759096 69.8397

TMOD3, MTOR, RICTOR

GO:0009225~nucleotide-sugar metabolic process 0.064317 GNE, GNPNAT1, B3GALNT2, CMAH 10 13588 4.139528 1 0.758924 70.06326

GO:0031329~regulation of cellular catabolic process 0.064553 HMGB1, ABHD5, PCSK9, PNPLA2, GIPC1, MTOR, 23 13588 2.699692 1 0.757942 70.1998

GM15387

GO:0021517~ventral spinal cord development 0.064553 IGHMBP2, MNX1, PAX6, ISL1, CLN8, HOXD10 23 13588 2.699692 1 0.757942 70.1998

GO:0051251~positive regulation of lymphocyte activation 0.066801 HSP90AA1, STAT5B, TNFSF14, IGH-6, BAD, 94 13588 1.651407 1 0.767776 71.47254

GM6212, CD24A, CD38, CORO1A, CDKN1A, TICAM1,

CD81, VNN1, H2-DMA, TCF3

GO:0035023~regulation of Rho protein signal transduction 0.06857 STMN3, MCF2, ARHGAP27, AKAP13, RICTOR, 86 13588 1.684692 1 0.774703 72.4382

ARHGEF12, ITSN1, ECT2, PLEKHG4, TIAM1, SOS1,

MTOR, SPATA13, FGD3

GO:0034622~cellular macromolecular complex assembly 0.068884 HIST1H4M, XPO1, HIST4H4, HIST1H4K, CAPZA2, 217 13588 1.383022 1 0.774103 72.6061

A730008H23RIK, GM10257, NAP1L1, EIF2A,

GM11275, TSPYL5, SMNDC1, MUSK, HIST1H4A, CSE1L, H2AFV, HIST1H4B, HJURP, CENPA, TUBB5,

H2AFZ, HIST1H4F, TUBE1, H2AFY, HIST1H4C,

HIST1H4D, PAK1, HIST1H4I, GEMIN6, TNPO2,

GM672

GO:0042113~B cell activation 0.070123 XRCC4, PIK3CD, GM6212, TPD52, SKAP2, CD24A, 78 13588 1.724803 1 0.778126 73.25968

FOXP1, HDAC5, BAX, MS4A1, BANK1, TCF3,

PIK3R1

GO:0016044~membrane organization 0.070486 STON2, ABCA7, OXA1L, LDLR, HIP1R, GULP1, 272 13588 1.33165 1 0.777769 73.44871

EPS15L1, TIMM50, GM6212, PMAIP1, ITSN1,

CD24A, CD47, CTTN, AP1S2, RABGEF1, CAP1,

EHD2, CLINT1, HIP1, LRP1B, STXBP1, DNHD1,

ARHGAP27, TIMM8B, MFN1, AP2A2, ADAM1A,

GAPVD1, BAX, OPHN1, LRP8, STEAP2, CLN8, DNM2

GO:0021510~spinal cord development 0.071149 IGHMBP2, SMO, PRRXL1, MNX1, PAX6, PAX3, 46 13588 2.024769 1 0.778879 73.79016

ISL1, CLN8, HOXD10

GO:0034621~cellular macromolecular complex subunit 0.071536 XPO1, HIST4H4, CAPZA2, GM10257, NAP1L1, 245 13588 1.351683 1 0.778638 73.98747 organization EIF2A, SMNDC1, H2AFV, SEH1L, H2AFZ, TUBB5,

H2AFY, PAK1, TUBB3, HIST1H1C, LOC100045490,

GM6142, H2AFJ, HIST2H4, TBCA, SLU7, CELF1,

STMN1, HIST1H4M, HIST1H4K, A730008H23RIK,

TSPYL5, GM11275, GFM2, MUSK, CSE1L, HIST1H4

GO:0005996~monosaccharide metabolic process 0.071911 ALDOA, GNE, GNPNAT1, PGD, GPI1, AKR1A4, 191 13588 1.40874 1 0.778345 74.17747

GALK1, TPI1, B3GALNT2, PRKAA1, GAPDH,

ALDOART1, GPD2, GPD1, LDHAL6B, ALDH5A1,

CMAH, PCDH12, BAD, DLAT, CPT1A, PGM2L1,

PGLS, POFUT2, PGK1, DCXR GO:0009063~cellular amino acid catabolic process 0.072145 MTHFD1, BCKDK, BCAT2, ASRGL1, MOXD2, 54 13588 1.916448 1 0.777379 74.29559

6530401N04RIK, ACAD8, DBH, HPD, AUH

GO:0022402~cell cycle process 0.072172 LZTS2, LOC623245, SEH1L, TUBB5, CCNA2, 393 13588 1.263978 1 0.775419 74.30879

TUBB3, ANAPC5, SGOL2, GM14138, GM6476,

GM11263, 4632434I11RIK, UBE2B, VASH1, BOLL,

KLHDC3, JMY, CCND1, REC8, MAD2L1, RCC2,

ZWINT, GM4796, MAPRE1, STMN1, NEK4, NEK6,

DHH, POLA1, CCNG1, SESN2, SESN3, GM16409,

NPM1, CAM

GO:0006412~translation 0.073378 GM6646, RPL17, GM10159, RPL15, HBS1L, EIF2A, 319 13588 1.297658 1 0.779107 74.90801

RPS27L, IGHMBP2, LOC623245, FAU, GM11945,

EIF2B3, RPS27A, MRPL52, GM16389, LOC676774,

GM14138, GM6476, GM11263, GM6834, MRPS5,

EIF1B, 2810422J05RIK, RPS19, MRPS18C,

GM7567, EIF4A2, RPS12, UBC, GM4796, RPS13,

UB

GO:0051173~positive regulation of nitrogen compound 0.074249 ENY2, TBX20, STAT5B, PAX6, ZXDC, ZXDB, PAX3, 526 13588 1.219823 1 0.781144 75.33272 metabolic process FOXO3, HOXD10, GATA5, TICAM1, PAX8, POU4F2,

CCNA2, RHOG, AVP, RARG, BRCC3, HSP90AA1,

TCFAP2B, RXRB, OTX2, HMGA1, UBE2B, PPARGC1B,

SMO, MURC, HES5, FOXC2, FOXC1, NSD1, ING5,

HMGB1, HMGB2, CNBP, SOX5, SOX6, ZBTB1

GO:0065003~macromolecular complex assembly 0.074314 XPO1, HIST4H4, ATL2, CAPZA2, GM10257, 338 13588 1.285948 1 0.779408 75.36392

NAP1L1, H2-D1, EIF2A, SMNDC1, IGHMBP2,

H2AFV, GTF2A1, H2AFZ, TUBB5, H2AFY, PAK1,

TUBB3, H2-L, HIST1H1C, OTC, GM6142, LOC100045490, H2AFJ, HIST2H4, TBCA, SLU7,

CELF1, PRNP, HIST1H4M, HIST1H4K,

A730008H23RIK, GM11275, T

GO:0030036~actin cytoskeleton organization 0.074483 DLC1, CNN3, CAPZA2, ARHGAP17, FHDC1, PFN2, 165 13588 1.442563 1 0.778166 75.4452

PALM2, LOC100047856, CAP1, EHD2, RHOG,

RICTOR, MYH6, RACGAP1, FMN1, MURC, EPB4.1L3,

CORO1A, PPP1R9A, NRAP, EPB4.1, OPHN1, USH1C,

AKAP2, CDC42BPB

GO:0051056~regulation of small GTPase mediated signal 0.075196 AGFG2, CSF1, AKAP13, ITSN1, 4933421I07RIK, 228 13588 1.361687 1 0.779457 75.78627 transduction PLEKHG4, GARNL3, TBC1D12, TIAM1, SOS1, GIT2,

FGD3, IQSEC1, TBC1D9B, STMN3, MCF2, PSD3,

ARHGAP27, RICTOR, ARHGEF12, ECT2, RALGAPA1,

GAPVD1, SGSM1, NUP62, ACAP1, TNK1, MTOR,

ARAP2, SPATA13

GO:0009820~alkaloid metabolic process 0.075334 PGLS, TPI1, NCF2, PGD, NADSYN1, DCXR 24 13588 2.587205 1 0.77809 75.85187

GO:0006769~nicotinamide metabolic process 0.075334 PGLS, TPI1, NCF2, PGD, NADSYN1, DCXR 24 13588 2.587205 1 0.77809 75.85187

GO:0046496~nicotinamide nucleotide metabolic process 0.075334 PGLS, TPI1, NCF2, PGD, NADSYN1, DCXR 24 13588 2.587205 1 0.77809 75.85187

GO:0043933~macromolecular complex subunit organization 0.076392 XPO1, HIST4H4, ATL2, CAPZA2, GM10257, 367 13588 1.268929 1 0.780938 76.34826

NAP1L1, H2-D1, EIF2A, SMNDC1, IGHMBP2,

H2AFV, GTF2A1, SEH1L, H2AFZ, TUBB5, H2AFY,

PAK1, TUBB3, H2-L, HIST1H1C, OTC, GM6142,

LOC100045490, H2AFJ, HIST2H4, TBCA, SLU7,

CELF1, STMN1, PRNP, HIST1H4M, HIST1H4K,

A730008H23R

GO:0050435~beta- metabolic process 0.076464 PSEN1, BACE1, IDE 5 13588 6.209292 1 0.779289 76.38184

GO:0002904~positive regulation of B cell apoptosis 0.076464 BAX, GM6212, CD24A 5 13588 6.209292 1 0.779289 76.38184 GO:0009103~lipopolysaccharide biosynthetic process 0.076464 GLT25D1, GNE, CERCAM 5 13588 6.209292 1 0.779289 76.38184

GO:0033152~immunoglobulin V(D)J recombination 0.076464 XRCC4, TCF3, FOXP1 5 13588 6.209292 1 0.779289 76.38184

GO:0001776~leukocyte homeostasis 0.076947 GM8779, STAT5B, GM14138, PIK3CD, GM11263, 39 13588 2.122835 1 0.779505 76.60463

GM6476, RPS6, LOC639593, GM16409, CORO1A,

GM13654, LOC623245, LILRB3, BAX, PPP3CB,

GM4796, SKIL

GO:0032103~positive regulation of response to external 0.076947 NTRK3, HMGB1, CD47, LOC640441, STAT5B, 39 13588 2.122835 1 0.779505 76.60463 stimulus FABP4, GM6212, GM15387, THBS1, CD24A

GO:0008283~cell proliferation 0.077799 MORF4L1, WNT5A, GNAI2, TBX20, POLA1, FKBP1A, 247 13588 1.340738 1 0.781373 76.99365

BOP1, PAX3, KRTAP16-7, PRDX1, LGR4, NAA35,

ACVR1C, ARX, GM16409, CSE1L, LOC623245,

CHUK, GINS1, A130010J15RIK, SPHK2, RXRB,

GM8779, GM14138, GM11263, GM6476, BAD,

RACGAP1, RPS6, PURB, LOC639593, ACVR2A,

CCND1,

GO:0051130~positive regulation of cellular component 0.078131 CAPZA2, PSRC1, IGH-6, SMAD2, GM6212, CBLL1, 122 13588 1.526875 1 0.780905 77.14304 organization RICTOR, CD24A, NTRK3, FMN1, CD47, TIAM1,

NPM1, MTOR, PTMS, WNT7A, NGF, HIP1

GO:0010604~positive regulation of macromolecule metabolic 0.078724 ENY2, TBX20, STAT5B, PAX6, ZXDC, ZXDB, PAX3, 633 13588 1.193466 1 0.781599 77.40858 process FOXO3, GM6212, PAWR, HOXD10, GATA5, TICAM1,

PAX8, POU4F2, CCNA2, RHOG, RARG, BRCC3,

TCFAP2B, RXRB, OTX2, HMGA1, UBE2B, PPARGC1B,

ACVR2A, SMO, MURC, PSEN1, PIAS4, HES5, CD81,

FOXC2, FOXC1, PIAS1, PTMS, NSD1, CLN

GO:0045935~positive regulation of nucleobase, nucleoside, 0.080853 ENY2, TBX20, STAT5B, PAX6, ZXDC, ZXDB, PAX3, 510 13588 1.217508 1 0.788887 78.33717 nucleotide and nucleic acid metabolic process FOXO3, HOXD10, GATA5, PAX8, POU4F2, CCNA2, RHOG, AVP, RARG, BRCC3, TCFAP2B, RXRB, OTX2,

HMGA1, UBE2B, PPARGC1B, SMO, MURC, HES5,

FOXC2, FOXC1, NSD1, ING5, HMGB1, HMGB2,

CNBP, SOX5, SOX6, ZBTB17, RGMB, TEF, POU2

GO:0006470~protein amino acid dephosphorylation 0.08132 GM8783, PTPRK, GM5951, PTPN14, PPM1A, 114 13588 1.543245 1 0.788978 78.536

TIMM50, GM15801, CDC25C, PTEN, PTPDC1,

CDC25A, LOC100044642, PPM1E, DUSP2, DUSP1,

PTP4A3, LOC100044742, PTP4A1, PPM1H,

DUSP16, PPP3CB, PPM1L

GO:0008610~lipid biosynthetic process 0.08184 CHKA, PGS1, SC5D, CDIPT, MVD, GNE, CYP11B2, 285 13588 1.307219 1 0.789292 78.75539

ABHD5, NDUFAB1, PIGK, TPI1, LPCAT1, INSIG2,

B3GNT5, PRKAA1, ELOVL6, PTDSS2, PIGA, SCD1,

GLT25D1, LPGAT1, SPHK2, CYP21A1, ACLY, PIGS,

CERCAM, PNPLA3, TECR, PIGO, CYP7B1, ST8SIA6,

MBOAT7, LASS2, CD81, MBOAT2, RNPE

GO:0001501~skeletal system development 0.08184 WNT5A, NOG, HOXA11, SOX5, PRRX1, SOX6, 285 13588 1.307219 1 0.789292 78.75539

ZBTB16, HOXD1, LOC100042019, GJA5, HOXD10,

PEX7, ACD, INSIG2, CTGF, HOXA9, ETL4, GPNMB,

RUNX1, PAPSS2, MN1, RPS27A, RARG, ARID5B,

SMAD2, GAS1, WWTR1, FMN1, HDAC5, ACVR2A,

SMO, 2810422J05RIK, SOST, GNAQ, PSEN1, UBC,

F

GO:0033365~protein localization in organelle 0.082249 SRP14, XPO1, SRP54A, SRP54B, SRP54C, PAX6, 97 13588 1.600333 1 0.789142 78.92648

DNHD1, TIMM8B, AIP, 6230409E13RIK, CSE1L,

SRPR, SPNB2, TOMM20, SRP72, GM14494, TNPO2,

LOC100044630, TNPO1 GO:0007005~mitochondrion organization 0.082249 DNHD1, TIMM50, PMAIP1, GM6212, CD24A, 97 13588 1.600333 1 0.789142 78.92648

TIMM8B, AIP, MFN1, GFM2, 6230409E13RIK,

MRPL15, BAX, MRPL17, TOMM20, GM14494,

LOC100044630, CLN8

GO:0051896~regulation of signaling 0.082287 RICTOR, ITSN1, PTEN, PHLDA3 11 13588 3.763207 1 0.787445 78.94198 cascade

GO:0012502~induction of programmed cell death 0.082463 C9, GSDMA, STK17B, FOXO3, GM6212, PMAIP1, 167 13588 1.425287 1 0.786337 79.01535

BAD, PTEN, CD24A, PRDX1, DAPK1, JMY, CASP6,

EI24, BAX, AEN, TICAM1, TRP53INP1, PCSK9,

APAF1, PERP, PHLDA3, IFI204

GO:0006917~induction of apoptosis 0.082463 C9, GSDMA, STK17B, FOXO3, GM6212, PMAIP1, 167 13588 1.425287 1 0.786337 79.01535

BAD, PTEN, CD24A, PRDX1, DAPK1, JMY, CASP6,

EI24, BAX, AEN, TICAM1, TRP53INP1, PCSK9,

APAF1, PERP, PHLDA3, IFI204

GO:0021515~cell differentiation in spinal cord 0.0825 IGHMBP2, MNX1, PAX6, PAX3, ISL1, CLN8, 32 13588 2.263804 1 0.784652 79.03072

HOXD10

GO:0016311~dephosphorylation 0.085121 GM8783, PPM1A, TIMM50, PTEN, MTMR2, DUSP16, 141 13588 1.467918 1 0.793559 80.09107

PPP3CB, MTMR9, MTMR7, PTPRK, GM5951, PTPN14,

GM15801, CDC25C, PTPDC1, CDC25A,

LOC100044642, DUSP2, PPM1E, LOC100044742,

PTP4A3, DUSP1, PTP4A1, PPM1H, PPM1L

GO:0000122~negative regulation of transcription from RNA 0.085472 EID1, NR6A1, PRRX1, CBX2, PAX3, SOX6, MSX3, 231 13588 1.344003 1 0.793169 80.22948 polymerase II promoter HEXIM1, ZKSCAN17, POU4F2, PER3, SKIL, TCF25,

NFX1, ETV3, RARG, KLF12, TRIM27, IRF2BP2,

TLE1, WWTR1, FOXP1, CTNNBIP1, HDAC5, HES5,

PIAS4, ID2, TGIF1, PHF21A, NSD1 GO:0034637~cellular carbohydrate biosynthetic process 0.086732 GPD2, GPD1, GLT25D1, TPI1, GNE, GNPNAT1, 56 13588 1.848003 1 0.796366 80.71791

PGD, CERCAM, GPI1, HS2ST1

GO:0008624~induction of apoptosis by extracellular signals 0.087025 BAX, TICAM1, GM6212, BAD, CD24A, DAPK1 25 13588 2.483717 1 0.795741 80.82963

GO:0045941~positive regulation of transcription 0.087757 ENY2, STAT5B, TBX20, PAX6, ZXDC, ZXDB, PAX3, 475 13588 1.220071 1 0.796826 81.10647

FOXO3, HOXD10, GATA5, PAX8, POU4F2, CCNA2,

RHOG, RARG, TCFAP2B, RXRB, OTX2, HMGA1,

PPARGC1B, MURC, SMO, HES5, FOXC2, FOXC1,

NSD1, ING5, HMGB1, HMGB2, CNBP, SOX5, SOX6,

ZBTB17, RGMB, TEF, POU2F1, RUNX1, TCF3, MY

GO:0007411~axon guidance 0.087867 PRRXL1, NRP1, KIF5C, PAX6, L1CAM, GAS1, 98 13588 1.584003 1 0.795504 81.14779

ISL1, ARX, FEZF1, LHX2, MNX1, POU4F2,

MAPK8IP3, B3GNT2, APBB1

GO:0043068~positive regulation of programmed cell death 0.087887 BCLAF1, C9, GSDMA, NFKBID, STK17B, GM6212, 250 13588 1.324649 1 0.793839 81.15532

ZBTB16, PMAIP1, FOXO3, PRDX1, CD24A, PTEN,

ACVR1C, CASP6, B230120H23RIK, AEN, TICAM1,

TRP53INP1, PCSK9, PHLDA3, RARG, BAD, JMY,

DAPK1, CDKN1A, EI24, PSEN1, BAX, APAF1,

PERP, APBB1, IFI204

GO:0021696~cerebellar cortex morphogenesis 0.088661 SMO, AGTPBP1, MTPN, LHX5, WNT7A 18 13588 2.874672 1 0.795095 81.44361

GO:0043029~T cell homeostasis 0.088661 GM8779, GM14138, STAT5B, GM11263, GM6476, 18 13588 2.874672 1 0.795095 81.44361

RPS6, LOC639593, GM16409, GM13654, CORO1A,

LOC623245, BAX, PPP3CB, GM4796

GO:0051270~regulation of cell motion 0.090032 GM8783, HMGB1, NRP1, EGFL7, GM5951, CSF1, 107 13588 1.547487 1 0.798584 81.94343

PAX6, GM15801, CBLL1, NEXN, PTEN, CORO1A,

LOC100044642, LOC100044742, LOC640441,

CLIC4, PTP4A1, RRAS, TMOD3, GM15387, STMN1-RS2, STMN1, THBS1, PIK3R1

GO:0003002~regionalization 0.090082 CER1, HOXA11, TBX20, PAX6, ABI1, ZBTB16, 214 13588 1.354051 1 0.797066 81.96138

HOXD10, SF3B1, ACD, DISP1, LHX2, HOXA9,

RARG, MAFB, OTX2, SMAD2, CELSR2, GAS1,

CTNNBIP1, SMO, ACVR2A, SFRP1, PSEN1, MNX1,

TGIF1, FOXC2, FOXC1, WNT7A

GO:0009310~amine catabolic process 0.092832 MTHFD1, BCKDK, BCAT2, ASRGL1, MOXD2, SMOX, 65 13588 1.751339 1 0.805513 82.92513

6530401N04RIK, ACAD8, DBH, HPD, AUH

GO:0014032~neural crest cell development 0.093008 NRP2, SMO, FGF15, FOXC2, FOXC1, PAX3, ISL1 33 13588 2.195204 1 0.804483 82.98518

GO:0014033~neural crest cell differentiation 0.093008 NRP2, SMO, FGF15, FOXC2, FOXC1, PAX3, ISL1 33 13588 2.195204 1 0.804483 82.98518

GO:0002696~positive regulation of leukocyte activation 0.09372 HSP90AA1, STAT5B, TNFSF14, IGH-6, BAD, 99 13588 1.568003 1 0.805382 83.22596

GM6212, CD24A, CD38, CORO1A, CDKN1A, TICAM1,

CD81, VNN1, H2-DMA, TCF3

GO:0010942~positive regulation of cell death 0.095081 BCLAF1, C9, GSDMA, NFKBID, STK17B, GM6212, 252 13588 1.314136 1 0.808553 83.67709

ZBTB16, PMAIP1, FOXO3, PRDX1, CD24A, PTEN,

ACVR1C, CASP6, B230120H23RIK, AEN, TICAM1,

TRP53INP1, PCSK9, PHLDA3, RARG, BAD, JMY,

DAPK1, CDKN1A, EI24, PSEN1, BAX, APAF1,

PERP, APBB1, IFI204

GO:0051272~positive regulation of cell motion 0.095379 GM8783, HMGB1, GM5951, CSF1, CBLL1, GM15801, 41 13588 2.019282 1 0.807969 83.77449

CORO1A, LOC100044642, LOC100044742,

LOC640441, PTP4A1, GM15387, STMN1-RS2,

STMN1, THBS1, PIK3R1

GO:0050769~positive regulation of neurogenesis 0.095379 NTRK3, SMO, XRCC4, TIAM1, NPTN, PAX6, BEX1, 41 13588 2.019282 1 0.807969 83.77449

NGF

GO:0007369~gastrulation 0.097554 CER1, GM8779, ARFRP1, GM14138, GM11263, 74 13588 1.678187 1 0.813832 84.46789 GM6476, SMAD2, ZBTB17, RPS6, LOC639593,

GM16409, ACVR2A, GM13654, LOC623245, FOXC2,

GM4796, FOXC1, EXT1, NSD1, CML3, ODZ4

GO:0055085~transmembrane transport 0.098851 KCNAB2, ATP5B, ZMAT3, AQP5, AQP4, NUP188, 460 13588 1.214861 1 0.816585 84.86787

TIMM50, AQP2, SEH1L, SLC25A3, GLE1,

AI317395, KCNQ2, ATP5H, NUP133, KCND3,

SLC12A8, SLC25A4, NUPL2, NUPL1, TIMM8B,

SLC26A4, SLC25A31, ABCB1B, SLC25A36,

SLC25A39, HIATL1, ATP6V0C-PS2, KCNA5,

ATP5G1, ATP6V1B2, GM100

GO:0007006~mitochondrial membrane organization 0.099601 BAX, DNHD1, TIMM50, PMAIP1, CLN8, TIMM8B 26 13588 2.388189 1 0.817487 85.09475