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Table S1. up Or Down Regulated Genes in Tcof1 Heterozygous

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Table S1. up Or Down Regulated Genes in Tcof1 Heterozygous Table S1. Up or down regulated genes in Tcof1 heterozygous haploinsufficiency mutant mice embryos involved in differentbiological process analysed by DAVID database Pop Pop Fold Term PValue Genes Bonferroni Benjamini FDR Hits Total Enrichment GO:0006793~phosphorus metabolic process 2.53E-07 RNASEL, CAPZA2, 4930444A02RIK, LPAR3, 866 13588 1.553518 8.11E-04 8.11E-04 4.59E-04 PSKH1, AAK1, B230120H23RIK, MAP3K8, PTPRK, BRAF, CSNK1G1, GM5951, MYLK4, PIK3CD, WNK1, PIM3, WNK2, CDKL3, STK4, PTPDC1, MARK1, MAP4K5, LOC100044742, ACAP1, NEK4, NEK6, WNT5A, GM8783, STK16, GNAI2, MVD, PTK7, STK17B, M GO:0006796~phosphate metabolic process 2.53E-07 RNASEL, CAPZA2, 4930444A02RIK, LPAR3, 866 13588 1.553518 8.11E-04 8.11E-04 4.59E-04 PSKH1, AAK1, B230120H23RIK, MAP3K8, PTPRK, BRAF, CSNK1G1, GM5951, MYLK4, PIK3CD, WNK1, PIM3, WNK2, CDKL3, STK4, PTPDC1, MARK1, MAP4K5, LOC100044742, ACAP1, NEK4, NEK6, WNT5A, GM8783, STK16, GNAI2, MVD, PTK7, STK17B, M GO:0016310~phosphorylation 8.10E-06 RNASEL, CAPZA2, 4930444A02RIK, LPAR3, 718 13588 1.52782 0.025664 0.012915 0.014693 PSKH1, AAK1, B230120H23RIK, MAP3K8, BRAF, CSNK1G1, MYLK4, PIK3CD, WNK1, PIM3, WNK2, CDKL3, STK4, MARK1, MAP4K5, ACAP1, NEK4, NEK6, WNT5A, STK16, GNAI2, MVD, STK17B, MAPKAPK3, PTK7, EPHA10, ATP6V1B2, ATP6V0C-PS2, GM100 GO:0015931~nucleobase, nucleoside, nucleotide and nucleic 1.55E-05 NCBP2, ENY2, NUP133, XPO1, GM5643, SLC25A4, 74 13588 2.936827 0.048626 0.016479 0.028169 acid transport HNRNPA2B1, NUP188, NUPL2, HNRNPA1, NUPL1, TMEM48, NUP62, DDX19A, SEH1L, NPM1, BAT1A, NUP54, GLE1, THOC3, SLC28A3, THOC1 GO:0050658~RNA transport 3.58E-05 NCBP2, ENY2, NUP133, XPO1, GM5643, 66 13588 2.979206 0.108617 0.028336 0.064964 HNRNPA2B1, NUP188, NUPL2, HNRNPA1, NUPL1, TMEM48, NUP62, DDX19A, SEH1L, NPM1, BAT1A, NUP54, GLE1, THOC3, THOC1 GO:0050657~nucleic acid transport 3.58E-05 NCBP2, ENY2, NUP133, XPO1, GM5643, 66 13588 2.979206 0.108617 0.028336 0.064964 HNRNPA2B1, NUP188, NUPL2, HNRNPA1, NUPL1, TMEM48, NUP62, DDX19A, SEH1L, NPM1, BAT1A, NUP54, GLE1, THOC3, THOC1 GO:0051236~establishment of RNA localization 3.58E-05 NCBP2, ENY2, NUP133, XPO1, GM5643, 66 13588 2.979206 0.108617 0.028336 0.064964 HNRNPA2B1, NUP188, NUPL2, HNRNPA1, NUPL1, TMEM48, NUP62, DDX19A, SEH1L, NPM1, BAT1A, NUP54, GLE1, THOC3, THOC1 GO:0007156~homophilic cell adhesion 4.01E-05 CADM3, CADM1, LOC100046008, PCDHGA9, 117 13588 2.388189 0.12068 0.025393 0.07266 PCDHGA8, PCDHGA7, PCDHGC5, L1CAM, PCDHGA6, PCDHGC4, PCDHGA5, PCDHGC3, PCDHGA4, PCDHGA3, PCDHGA2, PCDHGA1, CDH22, PCDHGB1, PCDHGA12, PCDHGA10, PCDHGA11, PCDHB5, PCDHB4, PCDH10, PCDHGB7, PCDH12, PCDHGB6, CELSR2, PCDHGB8, GO:0006403~RNA localization 4.46E-05 NCBP2, ENY2, NUP133, XPO1, GM5643, 67 13588 2.93474 0.133425 0.023585 0.080905 HNRNPA2B1, NUP188, NUPL2, HNRNPA1, NUPL1, TMEM48, NUP62, DDX19A, SEH1L, NPM1, BAT1A, NUP54, GLE1, THOC3, THOC1 GO:0006974~response to DNA damage stimulus 5.44E-05 MMS19, MORF4L1, HMGN1, XRCC4, ZMAT3, 287 13588 1.80293 0.160128 0.024621 0.098579 MORF4L2, 2310003H01RIK, FOXO3, PMAIP1, XRCC1, 2210018M11RIK, AEN, NSMCE1, PRMT6, FANCB, RTEL1, CIB1, POLK, REV1, BRCC3, 1110054O05RIK, LIG3, UBE2B, ESCO2, JMY, CCND1, UHRF1, RIF1, PSEN1, LOC100044391, RAD18, RAD23B, HM GO:0034613~cellular protein localization 7.91E-05 SRP14, XPO1, CLTA, OXA1L, AP4E1, GRIK2, 299 13588 1.765183 0.224187 0.031232 0.143366 AP2S1, PAX6, TOMM20L, PMAIP1, PEX7, AIP, CDC42, AP1S2, ANK2, SRPR, COPB1, GM2423, GM14494, SEC24D, SAR1A, SEC23A, STX6, SRP54A, SRP54B, SRP54C, TIMM8B, VTI1A, TOMM20, SRP72, COPG, STON2, ARL6IP1, AP1M1, AP1M2, RAB6, GO:0006397~mRNA processing 9.34E-05 NCBP2, RNASEL, RNMT, SNRPD3, GM11847, WBP4, 262 13588 1.816968 0.259101 0.032772 0.16935 YBX1, SMNDC1, TARDBP, PCBP1, BAT1A, PABPN1, GM5643, HNRNPA2B1, DDX39, GM8186, ESRP1, CPSF6, SLU7, CELF1, ESRP2, SNRPE, THOC3, THOC1, SNRPG, PRPF38A, GM11793, PPIL1, SF3B4, NAA38, HNRNPA3, SF3B1, SFRS15, HNRNPF, GO:0070727~cellular macromolecule localization 9.40E-05 SRP14, XPO1, CLTA, OXA1L, AP4E1, GRIK2, 301 13588 1.753454 0.260382 0.029712 0.170326 AP2S1, PAX6, TOMM20L, PMAIP1, PEX7, AIP, CDC42, AP1S2, ANK2, SRPR, COPB1, GM2423, GM14494, SEC24D, SAR1A, SEC23A, STX6, SRP54A, SRP54B, SRP54C, TIMM8B, VTI1A, TOMM20, SRP72, COPG, STON2, ARL6IP1, AP1M1, AP1M2, RAB6, GO:0006468~protein amino acid phosphorylation 9.65E-05 RNASEL, BCKDK, CAPZA2, 4930444A02RIK, 640 13588 1.487643 0.266343 0.027763 0.174892 LPAR3, EIF2A, ACVR1C, PSKH1, PAK3, AAK1, B230120H23RIK, MAP3K8, FERT2, PAK1, CDK16, CHUK, SIK3, CDK14, ADAM10, CAMK1G, BRAF, CSNK1G1, MTAP2, MYLK4, LOC100048768, WNK1, CDK9, PIM3, WNK2, CDK7, CDKL3, STK4, MARK1, DAPK1 GO:0006396~RNA processing 1.54E-04 NCBP2, RNASEL, RNMT, SNRPD3, TRMT2A, 437 13588 1.586661 0.390907 0.040474 0.279817 GM11847, WBP4, YBX1, SMNDC1, INTS5, LOC623245, TARDBP, PCBP1, BAT1A, FTSJ1, ZCCHC6, PABPN1, KRR1, GM5643, RPP21, EXOSC7, EXOSC4, HNRNPA2B1, GM14138, GM6476, GM11263, DDX39, LARP7, GM8186, ESRP1, GM4796, CPSF6, SLU7, CE GO:0051028~mRNA transport 1.95E-04 NCBP2, ENY2, NUP133, XPO1, GM5643, NUP188, 62 13588 2.83758 0.465668 0.047067 0.353596 NUPL2, HNRNPA1, NUPL1, TMEM48, NUP62, DDX19A, SEH1L, BAT1A, NUP54, GLE1, THOC3, THOC1 GO:0016071~mRNA metabolic process 1.97E-04 NCBP2, RNASEL, RNMT, SNRPD3, GM11847, WBP4, 302 13588 1.713381 0.468441 0.044135 0.356526 YBX1, AUH, SMNDC1, PCBP1, TARDBP, BAT1A, 1500002O20RIK, PABPN1, GM5643, HNRNPA2B1, DDX39, GM8186, ESRP1, CPSF6, SLU7, CELF1, ESRP2, SNRPE, THOC3, SNRPG, THOC1, PRPF38A, GM11793, PPIL1, SF3B4, NAA38, HNRNPA3, SF3 GO:0046907~intracellular transport 3.13E-04 NCBP2, XPO1, SRP14, CLTA, AP4E1, GRIK2, 431 13588 1.560727 0.633842 0.064785 0.566225 AP2S1, TOMM20L, PEX7, AIP, CDC42, ANKRD54, AP1S2, SRPR, COPB1, GM2423, GLE1, GM14494, SEC24D, SAR1A, STX6, SEC23A, NUP133, ADAM10, GM5643, LOC100048600, SRP54A, SRP54B, SRP54C, MYH6, TIMM8B, VTI1A, PSEN1, TOMM20, SR GO:0008380~RNA splicing 4.14E-04 NCBP2, GM11793, PPIL1, SNRPD3, GM11847, 201 13588 1.85352 0.734896 0.079628 0.74755 NAA38, SF3B4, WBP4, YBX1, SMNDC1, HNRNPA3, SF3B1, HNRNPF, TARDBP, USP39, BAT1A, HNRNPC, PABPC1, GEMIN6, SFRS14, PPWD1, GEMIN5, TXNL4B, GM5643, HNRNPA2B1, LOC100047806, SF3A2, HNRNPA1, DDX39, SFPQ, GM8186, ESRP1, SLU GO:0016477~cell migration 4.23E-04 CER1, NRP2, NRP1, SOX1, FGF15, CAPZA2, 240 13588 1.767923 0.743049 0.076822 0.76507 ATP5B, ASTN1, PAX6, GJA1, ABI2, GIPC1, GM6212, PAX3, CD24A, PTEN, PEX7, ARX, DAB1, CTGF, CLASP2, CAP1, TOP2B, PRRXL1, ARID5B, NR4A2, DBH, ISL1, FEZF1, SMO, CORO1A, NUP62, NAV1, PSEN1, BAX, MNX1, FOXC1, ALKBH1, LRP8, GO:0016337~cell-cell adhesion 5.89E-04 CADM3, CADM1, LOC100046008, PCDHGA9, 236 13588 1.754037 0.84931 0.099802 1.063929 PCDHGA8, PCDHGA7, PCDHGA6, L1CAM, GM6212, PCDHGA5, PCDHGA4, PCDHGA3, PCDHGA2, PCDHGA1, CDH22, CDC42, PCDHGB1, DAB1, CTGF, VNN1, PCDHGA12, PCDHGA10, PCDHGA11, ICAM4, PCDHB5, PCDHB4, PCDHGB7, PCDHGB6, PCDH7, PCDHGB8, PCD GO:0006886~intracellular protein transport 5.99E-04 XPO1, SRP14, CLTA, AP4E1, GRIK2, AP2S1, 276 13588 1.687308 0.854074 0.096336 1.081889 TOMM20L, AIP, PEX7, AP1S2, SRPR, COPB1, GM2423, GM14494, SAR1A, SEC24D, SEC23A, STX6, SRP54A, SRP54B, SRP54C, TIMM8B, VTI1A, TOMM20, SRP72, COPG, ARL6IP1, STON2, AP1M1, AP1M2, RAB6, GIPC1, CD24A, RAB7, STX12, CSE1L, GO:0006350~transcription 6.35E-04 STAT5B, 2810021G02RIK, HOXD10, NKX6-3, 1772 13588 1.23228 0.869816 0.096917 1.145687 CREB3L2, D330038O06RIK, A130010J15RIK, RARG, RXRB, ZHX1, ZFP467, MED11, LOC100047209, PPARGC1B, SUV420H2, UHRF1, RFC1, PIAS4, HES5, PRDM6, TGIF1, ZZZ3, TGIF2, PIAS1, TRAPPC2, HOXA11, MYEF2, TADA1, ARX, TAL2, HEXIM1, GO:0019637~organophosphate metabolic process 7.06E-04 CHKA, PGS1, CDIPT, SGPP1, ABHD5, PTEN, PIGK, 176 13588 1.881604 0.896462 0.102364 1.273553 TPI1, LPCAT1, PLA2G12A, PCSK9, PITPNC1, IP6K1, PIK3R1, PTDSS2, PIGA, GPD2, GPD1, SPHK2, LPGAT1, NCF2, ALDH5A1, TAZ, PIK3CD, PIGS, PIGO, MBOAT7, CD81, PLA2G4F, MBOAT2, GYK, CLN8 GO:0033554~cellular response to stress 8.02E-04 HMGN1, MORF4L1, MMS19, XRCC4, ZMAT3, 404 13588 1.536953 0.923863 0.110464 1.44493 MORF4L2, 2310003H01RIK, FOXO3, FGF12, PMAIP1, XRCC1, PRDX1, AQP2, OS9, MAP1LC3A, 2210018M11RIK, AEN, NSMCE1, PRMT6, FANCB, RTEL1, CIB1, POLK, 1110054O05RIK, REV1, BRCC3, LIG3, UBE2B, ESCO2, JMY, CCND1, UHRF1, RIF1, PSE GO:0001764~neuron migration 8.46E-04 PRRXL1, SOX1, CAPZA2, PAX6, NR4A2, GJA1, 70 13588 2.513285 0.93398 0.111451 1.524321 PEX7, FEZF1, ARX, DAB1, PSEN1, NAV1, BAX, MNX1, ALKBH1, TOP2B, APBB1 GO:0007155~cell adhesion 9.20E-04 MPZL3, NRP2, DLC1, CTNNAL1, CADM3, NRP1, 561 13588 1.438873 0.947828 0.115781 1.655257 MPZL2, CADM4, CADM1, LOC100046008, PCDHGA9, PCDHGA8, PCDHGA7, L1CAM, PCDHGA6, PCDHGA5, GM6212, PCDHGA4, PCDHGA3, PCDHGA2, PCDHGA1, CDH22, CD47, CDC42, PCDHGB1, DAB1, CTGF, VNN1, FERT2, PARD3B, SPON2, NEGR1, SPON1, GO:0022610~biological adhesion 9.71E-04 MPZL3, NRP2, DLC1, CTNNAL1, CADM3, NRP1, 562 13588 1.436313 0.955819 0.117308 1.747623 MPZL2, CADM4, CADM1, LOC100046008, PCDHGA9, PCDHGA8, PCDHGA7, L1CAM, PCDHGA6, PCDHGA5, GM6212, PCDHGA4, PCDHGA3, PCDHGA2, PCDHGA1, CDH22, CD47, CDC42, PCDHGB1, DAB1, CTGF, VNN1, FERT2, PARD3B, SPON2, NEGR1, SPON1, GO:0051493~regulation of cytoskeleton organization 0.001092 XPO1, STMN3, MTAP2, CAPZA2, PSRC1, RICTOR, 99 13588 2.195204 0.970029 0.126201 1.962882 KANK3, NEXN, ACTR3, FMN1, CORO1A, SPNB2, NPM1, CAPG, TMOD3, CLASP1, MTOR, MAPRE1, CLASP2, STMN1-RS2, STMN1, MAP6D1 GO:0060284~regulation of cell development 0.001253 XRCC4, NOG, NRP1, HOXA11, BEX1, PAX6, SOX5, 159 13588 1.887521 0.982159 0.138535 2.249879 GM6212, TIMP2, CD24A, MUSK, TIAM1, VWC2, SOCS2, NLGN1, SMAD2, ISL1, HDAC5, NTRK3, SMO, YWHAH, HES5, PSEN1, BAX, NPTN, TGIF1,
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