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List of Publications(Experimental Papers Are Followed by the List Of List of Publications (Experimental papers are followed by the list of books , of Reviews/Hypothesis/Consensus papers, and chapters). 32050 citations, H index: 92 by Google Scholar (may 2019): 255. Pirazzini M, Carle S, Barth H., Rossetto O, Montecucco C. Primary resistance of human patients to botulinum neurotoxins A and B. Ann. Clin. Transl. Neurology (2018) 5: 971-975. 254. Bano L, Tonon E, Drigo I, Pirazzini M, Guolo A, Farina G, Agnoletti F, Montecucco C. Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls. Toxins (Basel) (2018) 10. pii: E248. doi: 10.3390/toxins10060248. 253. Negro S, Stazi M, Marchioretto M, Tebaldi T, Rodella U, Duregotti E, Gerke V, Quattrone A, Montecucco C, Rigoni M, Viero G. Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2, and cytoskeletal remodeling in Schwann cells. RNA (2018) 24:915-925. doi: 10.1261/rna.064816.117. 252. Bano L, Drigo I, Tonon E, Pascoletti S, Puiatti C, Anniballi F, Auricchio B, Lista F, Montecucco C, Agnoletti F. Identification and characterization of Clostridium botulinum group III field strains by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS). Anaerobe (2017) 48:126-134. doi: 10.1016/j.anaerobe.2017.08.004. 251. Carle S, Pirazzini M, Rossetto O, Barth H, Montecucco C. High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins SuggestsThat These Pathogens Exerted Little or No Evolutionary Pressure on Humans. Toxins (Basel) (2017) 9. pii: E404. doi: 10.3390/toxins9120404. 250. Negro S, Lessi F, Duregotti E, Aretini P, La Ferla M, Franceschi S, Menicagli M, Bergamin E, Radice E, Thelen M, Megighian A, Pirazzini M, Mazzanti CM, Rigoni M & Montecucco C. CXCL12/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals. EMBO Mol. Med (2017) 9:1000-1010. doi: 10.15252/emmm.201607257. 249. Zornetta I, Scorzeto M, Mendes Dos Reis PV, De Lima ME, Montecucco C, Megighian A, Rossetto O. Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom. Toxins (Basel). (2017) Feb 27;9(3). pii: E81. doi: 10.3390/toxins9030081. 248. Rodella U, Negro S, Scorzeto M, Bergamin E, Jalink K, Montecucco C, Yuki N, Rigoni M. Schwann cells are activated by ATP released from neurons in an in vitro cellular model of Miller Fisher syndrome. Dis. Model. Mech. (2017) Jan 6. pii: dmm.027870. doi: 10.1242/dmm.027870. 247. Azarnia Tehran D, Pirazzini M, Leka O, Mattarei A, Lista F, Binz T, Rossetto O & Montecucco C. Hsp90 is involved in the entry of Clostridial Neurotoxins into the Cytosol of Nerve Terminals. Cell Microbiol. (2017) 19. doi: 10.1111/cmi.12647 246. Zornetta I, Azarnia Tehran D, Arrigoni G, Anniballi F, Bano L, Leka O, Zanotti G, Binz T & Montecucco C. The first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain. Sci Rep. (2016) 6:30257. doi: 10.1038/srep30257. 245. Rodella U, Scorzeto M, Duregotti E, Negro S, Dickinson BC, Chang CJ, Yuki N, Rigoni M & Montecucco C. An animal model of Miller Fisher syndrome: Mitochondrial hydrogen peroxide is produced by the autoimmune attack of nerve terminals and activates Schwann cells. Neurobiol Dis. (2016) 96:95-104. 244. Schnell L, Mittler AK, Mattarei A, Tehran DA, Montecucco C, Barth H. Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication. Toxins (Basel). (2016) 15;8:101 doi: 10.3390/toxins8070221. 243. Negro S, Bergamin E, Rodella U, Duregotti E, Scorzeto M, Jalink K, Montecucco C, Rigoni M.. ATP Released by Injured Neurons Activates Schwann Cells. Front Cell Neurosci. (2016) 10:134. doi: 10.3389/fncel.2016.00134. 242. Azarnia Tehran D, Zanetti G, Leka O, Lista F, Fillo S, Binz T, Shone CC, Rossetto O, Montecucco C, Paradisi C, Mattarei A, Pirazzini M. A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins. Sci Rep. (2015) 5:17513. doi: 10.1038/srep17513. 241. Duregotti E, Zanetti G, Scorzeto M, Megighian A, Montecucco C, Pirazzini M, Rigoni M. Snake and Spider Toxins Induce a Rapid Recovery of Function of Botulinum Neurotoxin Paralysed Neuromuscular Junction. Toxins (Basel) (2015) 7:5322-36. doi: 10.3390/toxins7124887.240. 240. Schnell L, Dmochewitz-Kück L, Feigl P, Montecucco C, Barth H. Thioredoxin reductase inhibitor auranofin prevents membrane transport of diphtheria toxin into the cytosol and protects human cells from intoxication. Toxicon (2015) 24101(15)00109-9. doi: 10.1016/j.toxicon. 239. Zanetti G, Azarnia Tehran D, Pirazzini M, Binz T, Shone CC, Fillo S, Lista F, Rossetto O, Montecucco C. Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism. Biochem Pharmacol. (2015) 98:522-30 doi: 10.1016/j.bcp.2015.09.023. 238. Caccin P, Scorzeto M, Damiano N, Marin O, Megighian A, Montecucco C. The synaptotagmin juxtamembrane domain is involved in neuroexocytosis. FEBS Open Bio.(2015) 5:388-96. doi: 10.1016/j.fob.2015.04.013. 237. Duregotti E, Scorzeto M, Negro S, Zornetta I, Dickinson BC, Chang CJ, Montecucco C*, Rigoni M* . Mitochondrial alarmins released by degenerating motor axon terminals activate perisynaptic Schwann cells. Proc Natl Acad Sci U S A. (2015) http://www.pnas.org/content/early/2015/01/15/1417108112.full.pdf+html Editor’s Choice: Leslie K. Ferrarelli . Summoning Schwann cells for neuromuscular recovery. Science Signalling (2015) 8, Issue 364, p. ec35 DOI: 10.1126/scisignal.aaa9059 236. Pirazzini M, Azarnia Tehran D, Zanetti G, Megighian A, Scorzeto M, Fillo S, Shone CC, Binz T, Rossetto O, Lista F, Montecucco C. Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins. Cell Rep. (2014) 8:1870-8. doi: 10.1016/j.celrep.2014.08.017. with highlight by: Montal M. Redox regulation of botulinum neurotoxin toxicity: therapeutic implications. Trends Mol Med. (2014) Sep 18. pii: S1471-4914(14)00142-7. doi: 10.1016/j.molmed.2014.09.005. 235. Mora-Obando D, Fernández J, Montecucco C, Gutiérrez JM, Lomonte B. Synergism between Basic Asp49 and Lys49 Phospholipase A2 Myotoxins of Viperid Snake Venom In Vitro and In Vivo. PLoS ONE (2014) 9: e109846. doi:10.1371/journal.pone.0109846 234. Lonati D, Giampreti A, Rossetto O, Petrolini VM, Vecchio S, Buscaglia E, Mazzoleni M, Chiara F, Aloise M, Gentilli A, Montecucco C, Coccini T, Locatelli CA. Neurotoxicity of European viperids in Italy: Pavia Poison Control Centre case series 2001-2011. Clin Toxicol (Phila). (2014) 52:269-76. doi:10.3109/15. 233. Leka O., Vallese F., Pirazzini M., Berto P., Montecucco C.*, Zanotti G.*. Diphtheria toxin conformational switching at acidic pH. FEBS J. (2014) 281:2115-22. doi: 10.1111/febs.12783 232. Vono M, Taccone M, Caccin P, Gallotta M, Donvito G, Falzoni S, Palmieri E, Pallaoro M, Rappuoli R, Di Virgilio F, De Gregorio E*, Montecucco C*, Seubert A. The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination. Proc Natl Acad Sci U S A. (2013) 110:21095-100. doi: 10.1073/pnas.1319784110. 231. Pirazzini M., Henke T, Rossetto O., Mahrhold S., Krez N., Rummel A., Montecucco C.*, Binz T*. Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain. FEBS Lett. (2013) 587:3831-6. 230. Megighian A, Zordan M, Pantano S, Scorzeto M, Rigoni M, Zanini D, Rossetto O, Montecucco C. Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction. J Cell Sci. (2013) 126:3134-40. doi: 10.1242/jcs.123802. 229. Pirazzini M, Bordin F, Rossetto O, Shone CC, Binz T, Montecucco C. The Thioredoxin Reductase-Thioredoxin System is involved in the Entry of Tetanus and Botulinum Neurotoxins in the Cytosol of Nerve Terminals. FEBS Lett. (2013) 587:150-5. doi: 10.1016/j.febslet.2012.11.007. 228.Colasante C, Morbiato L., Rossetto O, Pirazzini M, Molgo J. and Montecucco C. Botulinum Neurotoxin type A is Internalized and Translocates from Small Synaptic Vesicles at the Neuromuscular Junction. Mol. Neurobiol. (2013), 48:120-127. doi:10.1007/s12035-013-8423-9 227. Silva, DS Pereira, LMG Moreira, AM Silva, F Brito,R Faria T, Zornetta I, Montecucco C, Oliveira P, Azevedo JE, Pereira PJB, Macedo-Ribeiro , S do Vale A, dos Santos NMS. The apoptogenic toxin AIP56 is a metalloprotease A-B toxin that cleaves NF-κB p65. PLOS Pathogens (2013) 9:e1003128. doi: 10.1371/journal.ppat.1003128. 226. Pirazzini M, Rossetto O, Bertasio C, Bordin F, Shone CC, Binz T, Montecucco C. Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons. Biochem Biophys Res Commun. (2013) 430:38-42. doi: 10.1016/j.bbrc.2012.11.048. 225. Eleopra R, Montecucco C, Devigili G, Lettieri C, Rinaldo S, Verriello L, Pirazzini M, Caccin P, Rossetto O. Botulinum neurotoxin serotype D is poorly effective in humans: An in vivo electrophysiological study. Clin Neurophysiol. (2013) 124:999-1004. doi: 10.1016/j.clinph.2012.11.0042 224. Caccin P, Pellegatti P, Fernandez J, Vono M, Cintra-Francischinelli M, Lomonte B, Gutierrez JM, Di Virgilio F, Montecucco C. Why myotoxin-containing snake venoms possess powerful nucleotidases? Biochem Biophys Res Commun. (2013) :1289-93. doi: 10.1016/j.bbrc.2012.11.129. 223. Duregotti E, Tedesco E, Montecucco C, Rigoni M. Calpains participate in nerve terminal degeneration induced by spider and snake presynaptic neurotoxins. Toxicon (2013) 64:20-8. doi: 10.1016/j.toxicon.2012.12.0072. 222. Tonello F., Simonato M., Aita A., Pizzo P., Fernández J., Lomonte B., Gutiérrez JM and Montecucco C.
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