JAMA Dermatology Pages 501-600

In This Issue May 2016 Volume 152, Number 5 JAMA Dermatology Pages 501-600

Clinical Review & Education Research JAMA Dermatology Squamous Cell Carcinoma After Vismodegib Therapy 527 Clinicopathological Challenge Hedgehog pathway inhibitors, particularly smoothened inhibitors, are a new type of tar- geted therapy for advanced basal cell carcinoma. Cutaneous squamous cell carcinoma (CSCC) has been reported following vismodegib treatment, but no systemic assessment of this risk has been completed. In this case-control study, Mohan et al demonstrate an increased CSCC risk after vismodegib therapy, highlighting the importance of continued skin surveillance after treatment. Hedgehog pathway inhibition activates the RAS/MAPK pathway, thereby circumventing hedgehog pathway dependency for tumor growth. This RAS pathway dysregulation may promote CSCC and other second cancers. Editorial 521 567 What is your diagnosis? Sirolimus and Risk of Skin Cancer After Organ Transplant 533 LETTERS Solid-organ transplant recipients (OTRs) are at increased risk for skin cancer because of long-term immunosuppression. Mammalian target of rapamycin inhibitors (mTORs), such Observation as sirolimus, reduce the growth and proliferation of tumor cells, and cancer formation is 580 Cutaneous Presentation of Methicillin-Resistant Staphylococcus a major reason for conversion from calcineurin inhibitors to mTORs. In this retrospective aureus Sepsis in a Healthy Child cohort study, Karia et al demonstrate that patients taking sirolimus after developing post- W Wall and Coauthors transplant cancer had a lower risk of developing subsequent skin cancer and no increased 582 Safe Use of Therapeutic-Dose Oral risk for overall mortality. Isotretinoin in Patients With a History of Pseudotumor Cerebri Rosacea and Risk for Glioma 541 SJ Tintle and Coauthors 584 Melanoma Gene Expression Rosacea is a common infl ammatory facial skin disorder. The pathogenesis is poorly under- Markers for Surveillance of stood, although increased matrix metalloproteinase (MMP) activity may play an impor- Epidermolysis Bullosa Nevi Malignant tant role. Glioma accounts for 80% of primary central nervous system malignant tumors, Transformation and glioma also shows upregulation of MMP. In this nationwide cohort study, Egeberg et al JW Ahn and Coauthors demonstrate that rosacea was associated with a signifi cantly increased risk for glioma. In- 586 Recurrent Richter’s Transformation creased focus on neurologic symptoms such as headache, memory loss, seizures, visual Presenting With a Penile Ulcer T Yamany and Coauthors changes, or personality changes in patients with rosacea may be warranted. 587 Radiation Recall Dermatitis With Continuing Medical Education jamanetworkcme.com Concomitant Dabrafenib and Pazopanib Therapy Dermoscopy for Nonpigmented Basal Cell Carcinoma 546 S Haraldsdottir and Coauthors Basal cell carcinoma (BCC) is the most common type of skin cancer and is usually non- 589 Necrobiotic Xanthogranuloma pigmented. Dermoscopic features of pigmented BCC have been well described, but few Treated With Topical Nitrogen Mustard (Mechlorethamine) studies have focused on the dermoscopic features of nonpigmented BCCs, particularly O Rodriguez and Coauthors using polarized dermoscopy. In this study, Navarrete-Dechent et al demonstrate that the 590 Inverse Psoriasiform Eruption combined presence of shiny white blotches and strands in polarized dermoscopic images During Pembrolizumab Therapy for was associated with high diagnostic specifi city for nonpigmented BCC. These features Metastatic Melanoma should be added to criteria for BCC detection. MB Totonchy and Coauthors 592 Correction Treatment Decisions for Hidradenitis Suppurativa 553 Hidradenitis suppurativa (HS) is a potentially debilitating chronic infl ammatory disease Departments with implications for quality of life. Its inherent unpredictability poses considerable chal- 504 Staff Listing lenges to patient and physician alike, and studies evaluating predictors of disease severity 541 CME Article remain limited. In this retrospective cohort study, Garg et al demonstrate that HS had a 595 Classifi ed Advertising progressive course of disease. Clinical factors that played a role in developing partnered 597 Journal Advertiser Index short- and long-term treatment strategies included dermatologist referral, tobacco smok- 598 Contact Information ing, and age. Obesity and sex did not seem to infl uence treatment decisions in HS. 600 CME Questions Instructions for Authors www.jamadermatology.com/public /instructionsforauthors.aspx

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