The New D8 QUEST ECO Crystallography with a Conscience
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Biochemistry and the Genomic Revolution 1.1
Dedication About the authors Preface Tools and Techniques Clinical Applications Molecular Evolution Supplements Supporting Biochemistry, Fifth Edition Acknowledgments I. The Molecular Design of Life 1. Prelude: Biochemistry and the Genomic Revolution 1.1. DNA Illustrates the Relation between Form and Function 1.2. Biochemical Unity Underlies Biological Diversity 1.3. Chemical Bonds in Biochemistry 1.4. Biochemistry and Human Biology Appendix: Depicting Molecular Structures 2. Biochemical Evolution 2.1. Key Organic Molecules Are Used by Living Systems 2.2. Evolution Requires Reproduction, Variation, and Selective Pressure 2.3. Energy Transformations Are Necessary to Sustain Living Systems 2.4. Cells Can Respond to Changes in Their Environments Summary Problems Selected Readings 3. Protein Structure and Function 3.1. Proteins Are Built from a Repertoire of 20 Amino Acids 3.2. Primary Structure: Amino Acids Are Linked by Peptide Bonds to Form Polypeptide Chains 3.3. Secondary Structure: Polypeptide Chains Can Fold Into Regular Structures Such as the Alpha Helix, the Beta Sheet, and Turns and Loops 3.4. Tertiary Structure: Water-Soluble Proteins Fold Into Compact Structures with Nonpolar Cores 3.5. Quaternary Structure: Polypeptide Chains Can Assemble Into Multisubunit Structures 3.6. The Amino Acid Sequence of a Protein Determines Its Three-Dimensional Structure Summary Appendix: Acid-Base Concepts Problems Selected Readings 4. Exploring Proteins 4.1. The Purification of Proteins Is an Essential First Step in Understanding Their Function 4.2. Amino Acid Sequences Can Be Determined by Automated Edman Degradation 4.3. Immunology Provides Important Techniques with Which to Investigate Proteins 4.4. Peptides Can Be Synthesized by Automated Solid-Phase Methods 4.5. -
Nagy Rock 'N' Roll Könyv
Szakács Gábor Nagy rock ʼnʼ roll könyv Szakács Gábor „Ahogy SzakácsSzakács GáborGábor mondjamondja aa műfajábanműfajában egyedülegyedülálló álló Nagy rock’n’rollOzzy Osbourne: c. könyvében: …el kell döntenünk, hogy zajt vagy zenét aka- runk„Amikor hallani.” fiam rehabilitációján megismertem a szerek mélységét, és ez hasonló a heroinhoz, teljesen ledöbbentem.Juhász Kristóf: 55 éves Magyar vagyok Idők és 2017/3/7.hátralé- vô életemben újra kell gondolnom sok mindent, mivel saját magamat is hihetetlenül hosszú ideig károsítottam.” Ozzy Osbourne: „Amikor fiam rehabilitációján megismertem a szerek mélységét, és ez hasonló a heroinhoz, teljesen ledöbbentem. 55 éves vagyok és hátralévő életemben újra kell gondolnom sok mindent, mivel saját magamat is hihetetlenül hosszú ideig károsítottam.” A szerző külünköszönetet köszönetet mond mondaz Attila az ifjúságaAttila ifjúsága lemez zenészeinek:zenészeinek: Kecskés együttes: L. Kecskés András, Kecskés Péter, Herczegh László, Lévai Péter, Nagyné Bartha Anna ifjúifj.© Szakács CsoóriCsoóri Gábor, SándorLászló 2004. június Rock:ISBN Bernáth 963 216 329Tibor, X Berkes Károly, Bóta Zsolt, Horváth János, Hor- váth Menyhért, Papp Gyula, Sárdy Barbara, Szász Ferenc A szerző köszönetet mond Valkóczi Józsefnek a könyv javításáért. © Szakács Gábor, 2004. június, 2021 ISBN© Szakács 963 216Gábor, 329 2004. X június, 2021. február ISBN 963 216 329 X FOTÓK: Antal Orsolya, Ágg Károly, Becskereki Dusi, Dávid Zsolt, Galambos Anita, Knapp Zoltán, Rásonyi Mária, Tóth Tibor BORÍTÓTERV, KÉPFELDOLGOZÁS: FortekFartek Zsolt KIADVÁNYSZERKESZTÔ: Székely-Magyari Hunor KIADÓ ÉS NYOMDA: Holoprint Kft. • 1163 Bp., Veres Péter út 37. Tel.: 403-4470, fax: 402-0229, www.holoprint.hu Nagy Rock ʼnʼ Roll Könyv Tartalomjegyzék Elôszó . 4 Így kezdôdött . 6 Írók, költôk, hangadók . 15 Családok, gyermekek, utódok . 24 Indulás, feltûnés, beérkezés . -
Obscured Asymptotic Giant Branch Stars in the Magellanic Clouds IV
A&A manuscript no. (will be inserted by hand later) ASTRONOMY AND Your thesaurus codes are: ASTROPHYSICS 06(08.03.1; 08.03.4; 08.13.2; 08.16.4; 11.13.1; 13.09.6) 6.9.2018 Obscured Asymptotic Giant Branch stars in the Magellanic Clouds IV. Carbon stars and OH/IR stars⋆ Jacco Th. van Loon1,2, Albert A. Zijlstra1, Patricia A. Whitelock3, Peter te Lintel Hekkert4, Jessica M. Chapman5,6, Cecile Loup7,8, M.A.T. Groenewegen9, L.B.F.M. Waters2,10 and Norman R. Trams11 1 European Southern Observatory, Karl-Schwarzschild Straße 2, D-85748 Garching bei M¨unchen, Germany 2 Astronomical Institute, University of Amsterdam, Kruislaan 403, NL-1098 SJ Amsterdam, The Netherlands 3 South African Astronomical Observatory, P.O.Box 9, 7935 Observatory, Republic of South Africa 4 Australia Telescope National Facility, Parkes Observatory, P.O.Box 276, Parkes, NSW 2870, Australia 5 Anglo-Australian Observatory, P.O.Box 296, Epping, NSW 2121, Australia 6 Australia Telescope National Facility, P.O.Box 76, Epping, NSW 2121, Australia 7 European Southern Observatory, Casilla 19001, Santiago 19, Chile 8 Institut d’Astrophysique de Paris, 98bis Boulevard Arago, F-75014 Paris, France 9 Max-Planck Institut f¨ur Astrophysik, Karl-Schwarzschild Straße 1, D-85740 Garching bei M¨unchen, Germany 10 Space Research Organization Netherlands, Landleven 12, NL-9700 AV Groningen, The Netherlands 11 ISO Science Operations Centre, Astrophysics Division of ESA, Villafranca del Castillo, P.O.Box 50727, E-28080 Madrid, Spain Received date; accepted date Abstract. We present N-band photometry for a sample Key words: Stars: carbon – circumstellar matter – Stars: of 21 dust-enshrouded AGB stars in the Large Magellanic mass loss – Stars: AGB and post-AGB – Magellanic Cloud, and three additional sources in the Small Magel- Clouds – Infrared: stars lanic Cloud. -
See the Scientific Petition
May 20, 2016 Implement the Endangered Species Act Using the Best Available Science To: Secretary Sally Jewell and Secretary Penny Prtizker We, the under-signed scientists, recommend the U.S. government place species conservation policy on firmer scientific footing by following the procedure described below for using the best available science. A recent survey finds that substantial numbers of scientists at the U.S. Fish and Wildlife Service (FWS) and the National Oceanic and Atmospheric Administration believe that political influence at their agency is too high.i Further, recent species listing and delisting decisions appear misaligned with scientific understanding.ii,iii,iv,v,vi For example, in its nationwide delisting decision for gray wolves in 2013, the FWS internal review failed the best science test when reviewed by an independent peer-review panel.vii Just last year, a FWS decision not to list the wolverine ran counter to the opinions of agency and external scientists.viii We ask that the Departments of the Interior and Commerce make determinations under the Endangered Species Actix only after they make public the independent recommendations from the scientific community, based on the best available science. The best available science comes from independent scientists with relevant expertise who are able to evaluate and synthesize the available science, and adhere to standards of peer-review and full conflict-of-interest disclosure. We ask that agency scientific recommendations be developed with external review by independent scientific experts. There are several mechanisms by which this can happen; however, of greatest importance is that an independent, external, and transparent science-based process is applied consistently to both listing and delisting decisions. -
Community Foundation of Jackson Hole Annual
COMMUNITY FOUNDATION OF JACKSON HOLE ANNUAL REPORT / 2018 TA B L E Welcome Letter 3 OF CONTENTS About Us 4 Donor Story 6 Professional Development & Resources 8 Competitive Grants 10 Youth Philanthropy 12 Micro Grants 16 Opportunities Fund 18 Collective Impact 20 Legacy Society 24 1 Fund Highlights 24-25 Key Financial Indicators 26 Donor Story 28 The Foundation Circle 30 Community Foundation Funds 34 Old Bill’s Fun Run 36 Co-Challengers 38 Friends of the Match 42 Gifts to Funds 44 Community Foundation of Teton Valley 46 Behind the Scenes 48 In Memoriam 50 Community Foundation of Jackson Hole / Annual Report 2018 2 Fund & Program Highlight HELLO, Mr. and Mrs. Old Bill say it best. They have always led with the question, “How can we help?” Their initial vision was to inspire “we” to become “all of us.” And it has. In 2018, you raised an astonishing amount, bringing Old Bill’s Fun Run’s 22-year total to more than $159 million for local nonprofits. Inside these pages, you will see the impact of our remarkable community’s generosity. In fact, one out of every three families in Teton County takes part in Old Bill’s—an event that has become a national model for collaborative fundraising. Old Bill’s lasts only a morning, but because of your support, we are touching lives and working for the community 3 every day. Nonprofits rely on us for professional workshops and resources and receive critical funding through our Competitive and Capacity Building grant opportunities. We convene Community Conversations to find collaborative solutions to local problems. -
Los Premios Nobel De Química
Los premios Nobel de Química MATERIAL RECOPILADO POR: DULCE MARÍA DE ANDRÉS CABRERIZO Los premios Nobel de Química El campo de la Química que más premios ha recibido es el de la Quí- mica Orgánica. Frederick Sanger es el único laurea- do que ganó el premio en dos oca- siones, en 1958 y 1980. Otros dos también ganaron premios Nobel en otros campos: Marie Curie (física en El Premio Nobel de Química es entregado anual- 1903, química en 1911) y Linus Carl mente por la Academia Sueca a científicos que so- bresalen por sus contribuciones en el campo de la Pauling (química en 1954, paz en Física. 1962). Seis mujeres han ganado el Es uno de los cinco premios Nobel establecidos en premio: Marie Curie, Irène Joliot- el testamento de Alfred Nobel, en 1895, y que son dados a todos aquellos individuos que realizan Curie (1935), Dorothy Crowfoot Ho- contribuciones notables en la Química, la Física, la dgkin (1964), Ada Yonath (2009) y Literatura, la Paz y la Fisiología o Medicina. Emmanuelle Charpentier y Jennifer Según el testamento de Nobel, este reconocimien- to es administrado directamente por la Fundación Doudna (2020) Nobel y concedido por un comité conformado por Ha habido ocho años en los que no cinco miembros que son elegidos por la Real Aca- demia Sueca de las Ciencias. se entregó el premio Nobel de Quí- El primer Premio Nobel de Química fue otorgado mica, en algunas ocasiones por de- en 1901 al holandés Jacobus Henricus van't Hoff. clararse desierto y en otras por la Cada destinatario recibe una medalla, un diploma y situación de guerra mundial y el exi- un premio económico que ha variado a lo largo de los años. -
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Introduction Have you ever seen those little About the International Year of Crystallography pictures of a molecule of your The United Nations declares 2014 as the official International Year of prescribed medication? …or a drawing Crystallography. It commemorates not only the centennial of X-ray of DNA showing two strands winding Amoxicillin diffraction, which allowed the detailed study of crystalline material, but also the 400th anniversary of Kepler’s observation in 1611 of the What do around each other? symmetrical form of ice crystals, which began the wider study of the role Molecules are too small to be seen by of symmetry in matter. New Drug Design, normal microscopy. Learn more at http://iycr2014.org X-ray crystallography is one of the DNA Studies few techniques that can visualize them About IUCr The International Union of Crystallography is a not-for- and was used to determine the first Schematic picture profit, scientific organization that aims to: and molecular structures ever known. of DNA • promote international cooperation in crystallography • contribute to all aspects of crystallography X-rays X-rays & X-ray Crystallography • promote international publication of crystallographic research have in common? How They Work • facilitate standardization of methods, units, nomenclatures and symbols • form a focus for the relations of crystallography to other sciences • X-ray beams are shot through • We calculate how the diffracted a crystal composed of the X-rays would look, if they The IUCr fulfils these objectives by publishing -
GEORGE Mclean: Intimate Moments in Nature
Soul of the Bay Nature / Culture / Recreation www.georgianbaytodaynews.com GEORGE McLEAN: Intimate moments in nature Spring 2017 Issue #116 $2.65 plus tax Bill Davis: Legacy on Georgian Bay Legendary Hunt ‘Deep-V’ on the Bay 2 GEORGIAN BAY TODAY Spring 2017 www.georgianbaytodaynews.com www.georgianbaytodaynews.com GEORGIAN BAY TODAY Spring 2017 3 Thank goodness the ‘Denier Industry’ Legendary ‘Deep-V’s and the Payne family legacy BAY TODAY missed the Ozone problem generation, landmark business in Pointe au Baril. Current proprietor, By David Sweetnam , Executive Director Georgian Bay Forever Mark Payne, “grew up in the business, started by cutting grass Thank good- repairing itself and protecting the the Grand Canyon from behind a and pumping gas.” The business had ness the Denier earth once again from harmful secure railing. And if the denial humble, but proud beginnings. It Industry missed cancer-causing ultraviolet rays. This industry had been as well formed in was started by Mark’s grandfather Georgian Bay Today the Ozone problem. is happening because scientists, the 1970s as it is today the world Vince, a Toronto watchmaker, and Issue 116 governments, manufacturers and would already have been well on its Mark’s father, Mike, in 1960. They Spring 2017 Spring is here citizens all worked together to way to becoming a hostile, irradiated began with nothing more than a and our thoughts address a truly life-threatening planet. dilapidated building and a chicken Publisher turn towards the global emergency. coup. The first priority was to build Bird Room Press record heat of Halogenated hydrocarbon a house to survive their first winter. -
Meet the Scientist Linus Pauling (1901-1994)
Meet the Scientist Linus Pauling (1901-1994) Do you know that different cells have certain unique proteins that have unique jobs? Muscles have proteins that contract, enabling the muscle cell to contract. Pancreas cells make the protein insulin, which regulates blood sugar levels. There are unique cells in the part of the brain called the hypothalamus that make small unique proteins that trigger the release of pituitary hormones. There are proteins in nerve cells that work to create new axon terminals and synapses that store your memories? How many other examples can you think of cells with specific proteins? A British journal included only Linus Pauling and Einstein from the 20th Century in their list of the greatest scientists in the history of the world. As you will see, Linus made major discoveries about chemical bonding and the structure of proteins―pretty heady stuff for a high-school dropout. He didn’t drop out because school was too hard. For him, it was too easy. Some scientists are born with a silver spoon in their mouth. But not Linus Pauling. From age 4 to 9, Linus lived in a small Oregon town, which was like an outpost in the Old West. The town had one street, lined by stores with false fronts on many of the buildings, as you see on cowboy movie sets today. Real cowboys lounged in front of the general store, and real Indians camped on the edge of town. His father, Herman, was a self-taught pharmacist and "medicine man." He ran a drug store in town. -
Contributions of Civilizations to International Prizes
CONTRIBUTIONS OF CIVILIZATIONS TO INTERNATIONAL PRIZES Split of Nobel prizes and Fields medals by civilization : PHYSICS .......................................................................................................................................................................... 1 CHEMISTRY .................................................................................................................................................................... 2 PHYSIOLOGY / MEDECINE .............................................................................................................................................. 3 LITERATURE ................................................................................................................................................................... 4 ECONOMY ...................................................................................................................................................................... 5 MATHEMATICS (Fields) .................................................................................................................................................. 5 PHYSICS Occidental / Judeo-christian (198) Alekseï Abrikossov / Zhores Alferov / Hannes Alfvén / Eric Allin Cornell / Luis Walter Alvarez / Carl David Anderson / Philip Warren Anderson / EdWard Victor Appleton / ArthUr Ashkin / John Bardeen / Barry C. Barish / Nikolay Basov / Henri BecqUerel / Johannes Georg Bednorz / Hans Bethe / Gerd Binnig / Patrick Blackett / Felix Bloch / Nicolaas Bloembergen -
From the President New Program to Boost Membership
July August 2011 · Volume 20, Number 4 New Program to From the President Boost Membership igma Xi’s new Member-Get-A-Member Dear Colleagues and Companions in Zealous Research program gives all active Sigma Xi It is indeed an honor for me to have been elected president of our Smembers a chance to earn a free year international honor society for scientists and engineers. Sigma Xi of membership by was created 125 years ago with high ideals, a worthy mission and recommending five an inspiring vision that remain critical to science and engineering in the 21st Century. new members during As incoming president, I will seek to further the mission of Sigma Xi. a one-year period. Public confidence in the fundamental truths derived from application of science is Active Sigma Xi members should perhaps more critical now than at any time in the history of our honor society. From recommend their qualified friends, students, openness in research to accuracy in conducting and reporting research to integrity in colleagues and fellow scientists and engineers the peer review process and authorship, we have an obligation to our members and the to the honor of Sigma Xi membership. Any public to focus on these issues. active Sigma Xi member who recommends I applaud my friend and colleague, our immediate past-president, Joe Whitaker. Dr. five new members who are then approved Whitaker deserves our gratitude for providing outstanding leadership and initiating for membership between now and June 30, a new hope for the evolution of our esteemed honor society. My intention will be to 2012 will receive one free year of Sigma Xi build upon the spark Joe ignited during his tenure, and implement an enabling strategy membership. -
Crystallography News British Crystallographic Association
Crystallography News British Crystallographic Association Issue No. 125 June 2013 ISSN 1467-2790 Coming soon: ECM28 AGM of the BCA p6 Bragg Centenary Events p9 Bursary Recipientsʼ Reports p15 Worldwide Protein Data Bank p16 News from the Groups p20 EXPERIENCE TRUE BRILLIANCE Confidence means a revolutionary high-brilliance X-ray system that meets the needs of the most challenging crystallography projects. Agilent’s new GV1000 X-ray diffractometer represents a major leap forward in the generation of X-rays for demanding structural biology applications. The GV1000 combines novel approaches in all core source components, with innovative gradient vacuum technology affording an extremely compact, quiet and high-brilliance X-ray source. See macromolecular structures in a whole new light with the brilliant new Agilent GV1000 X-ray diffractometer. Learn more at www.agilent.com/lifesciences/GV1000. Discover the powerful new features in Agilent’s CrysAlisPro software. Register for our 2013 Software and Applications Webinar Series at www.agilent.com/chem/xray_eSeminars © Agilent Technologies, Inc. 2013 PDF-4/Organics 2013 What’s in your sample? Verify your results with PDF-4/Organics A comprehensive materials database featuring 471,257 organic and organometallic compounds. Designed for rapid materials identifi cation Polymorph screening Quality control Drug & Excipients identifi cation Formulation analysis Quantitative analysis Polymorph identifi cation Crystallite size COMPREHENSIVE ❖ STANDARDIZED ❖ QUALITY REVIEW www.icdd.com | marketing @icdd.com 610.325.9814 | toll-free 866.378.9331 (U.S. & Canada) ICDD, the ICDD logo and PDF are registered in the U.S. Patent and Trademark Offi ce. Powder Diff raction File is a trademark of JCPDS—International Centre for Diff raction Data.