Pauling: Charismatic, Controversial, and Tough
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Biochemistry and the Genomic Revolution 1.1
Dedication About the authors Preface Tools and Techniques Clinical Applications Molecular Evolution Supplements Supporting Biochemistry, Fifth Edition Acknowledgments I. The Molecular Design of Life 1. Prelude: Biochemistry and the Genomic Revolution 1.1. DNA Illustrates the Relation between Form and Function 1.2. Biochemical Unity Underlies Biological Diversity 1.3. Chemical Bonds in Biochemistry 1.4. Biochemistry and Human Biology Appendix: Depicting Molecular Structures 2. Biochemical Evolution 2.1. Key Organic Molecules Are Used by Living Systems 2.2. Evolution Requires Reproduction, Variation, and Selective Pressure 2.3. Energy Transformations Are Necessary to Sustain Living Systems 2.4. Cells Can Respond to Changes in Their Environments Summary Problems Selected Readings 3. Protein Structure and Function 3.1. Proteins Are Built from a Repertoire of 20 Amino Acids 3.2. Primary Structure: Amino Acids Are Linked by Peptide Bonds to Form Polypeptide Chains 3.3. Secondary Structure: Polypeptide Chains Can Fold Into Regular Structures Such as the Alpha Helix, the Beta Sheet, and Turns and Loops 3.4. Tertiary Structure: Water-Soluble Proteins Fold Into Compact Structures with Nonpolar Cores 3.5. Quaternary Structure: Polypeptide Chains Can Assemble Into Multisubunit Structures 3.6. The Amino Acid Sequence of a Protein Determines Its Three-Dimensional Structure Summary Appendix: Acid-Base Concepts Problems Selected Readings 4. Exploring Proteins 4.1. The Purification of Proteins Is an Essential First Step in Understanding Their Function 4.2. Amino Acid Sequences Can Be Determined by Automated Edman Degradation 4.3. Immunology Provides Important Techniques with Which to Investigate Proteins 4.4. Peptides Can Be Synthesized by Automated Solid-Phase Methods 4.5. -
See the Scientific Petition
May 20, 2016 Implement the Endangered Species Act Using the Best Available Science To: Secretary Sally Jewell and Secretary Penny Prtizker We, the under-signed scientists, recommend the U.S. government place species conservation policy on firmer scientific footing by following the procedure described below for using the best available science. A recent survey finds that substantial numbers of scientists at the U.S. Fish and Wildlife Service (FWS) and the National Oceanic and Atmospheric Administration believe that political influence at their agency is too high.i Further, recent species listing and delisting decisions appear misaligned with scientific understanding.ii,iii,iv,v,vi For example, in its nationwide delisting decision for gray wolves in 2013, the FWS internal review failed the best science test when reviewed by an independent peer-review panel.vii Just last year, a FWS decision not to list the wolverine ran counter to the opinions of agency and external scientists.viii We ask that the Departments of the Interior and Commerce make determinations under the Endangered Species Actix only after they make public the independent recommendations from the scientific community, based on the best available science. The best available science comes from independent scientists with relevant expertise who are able to evaluate and synthesize the available science, and adhere to standards of peer-review and full conflict-of-interest disclosure. We ask that agency scientific recommendations be developed with external review by independent scientific experts. There are several mechanisms by which this can happen; however, of greatest importance is that an independent, external, and transparent science-based process is applied consistently to both listing and delisting decisions. -
Los Premios Nobel De Química
Los premios Nobel de Química MATERIAL RECOPILADO POR: DULCE MARÍA DE ANDRÉS CABRERIZO Los premios Nobel de Química El campo de la Química que más premios ha recibido es el de la Quí- mica Orgánica. Frederick Sanger es el único laurea- do que ganó el premio en dos oca- siones, en 1958 y 1980. Otros dos también ganaron premios Nobel en otros campos: Marie Curie (física en El Premio Nobel de Química es entregado anual- 1903, química en 1911) y Linus Carl mente por la Academia Sueca a científicos que so- bresalen por sus contribuciones en el campo de la Pauling (química en 1954, paz en Física. 1962). Seis mujeres han ganado el Es uno de los cinco premios Nobel establecidos en premio: Marie Curie, Irène Joliot- el testamento de Alfred Nobel, en 1895, y que son dados a todos aquellos individuos que realizan Curie (1935), Dorothy Crowfoot Ho- contribuciones notables en la Química, la Física, la dgkin (1964), Ada Yonath (2009) y Literatura, la Paz y la Fisiología o Medicina. Emmanuelle Charpentier y Jennifer Según el testamento de Nobel, este reconocimien- to es administrado directamente por la Fundación Doudna (2020) Nobel y concedido por un comité conformado por Ha habido ocho años en los que no cinco miembros que son elegidos por la Real Aca- demia Sueca de las Ciencias. se entregó el premio Nobel de Quí- El primer Premio Nobel de Química fue otorgado mica, en algunas ocasiones por de- en 1901 al holandés Jacobus Henricus van't Hoff. clararse desierto y en otras por la Cada destinatario recibe una medalla, un diploma y situación de guerra mundial y el exi- un premio económico que ha variado a lo largo de los años. -
Martin Karplus &LISTING RELEASE IMMEDIATE for 7:30 PM PM 7:30 SEP 24 52 East 11 Cultural New Forum Austrian York SEP 25 1953 Photographs MARTIN KARPLUS Exhib
FOR IMMEDIATE RELEASE & LISTING Exhibition: MARTIN KARPLUS Photographs 1953 – 2009 SEP 25 – NOV 28, 2014 Austrian Cultural Forum New York 11 East 52nd Street, New York SEP 24 | EXHIBITION OPENING 7:30 PM – 9PM (no RSVP req'd) Self Portrait of Martin Karplus, Marineland of the pacific, California, USA 1956 Martin Karplus is a chemist, Professor emeritus at Harvard University, and Nobel laureate who has spent the past treet treet york| new | ny 10022 | phone:(212) 319 5300 | (212) fax: 644 8660 [email protected] | | www.acfny.org fifty years consumed by a passion for documenting humanity in thousands of photographs. Sourced from Europe, s Asia, and the Americas, these photographs candidly capture societies at pivotal moments in their cultural and nd economic development in rich Kodachrome color. From September 25 through November 28, the Austrian Cultural Forum New York will present these works in his first ever New York retrospective, Martin Karplus | Photographs 1953- 2009. In 1953, nearing the completion of his PhD at Cal Tech, the Austrian-born, American Karplus received his uncle’s Leica camera as a gift from his parents and headed to Oxford University on a fellowship. In the ensuing years he austriancultural forum | east 11 52 would spend months on end exploring the globe, documenting what he describes in his artist statement as a “vision of a world, much of which no longer exists”. Images from the Netherlands, Denmark, Greece, Italy, France, Yugoslavia, and Germany present the closure of a bygone lifestyle as societies modernized and rebuilt in the wake of World War II and the dawning of the Cold War. -
Nfap Policy Brief » October 2019
NATIONAL FOUNDATION FOR AMERICAN POLICY NFAP POLICY BRIEF» OCTOBER 2019 IMMIGRANTS AND NOBEL PRIZES : 1901- 2019 EXECUTIVE SUMMARY Immigrants have been awarded 38%, or 36 of 95, of the Nobel Prizes won by Americans in Chemistry, Medicine and Physics since 2000.1 In 2019, the U.S. winner of the Nobel Prize in Physics (James Peebles) and one of the two American winners of the Nobel Prize in Chemistry (M. Stanley Whittingham) were immigrants to the United States. This showing by immigrants in 2019 is consistent with recent history and illustrates the contributions of immigrants to America. In 2018, Gérard Mourou, an immigrant from France, won the Nobel Prize in Physics. In 2017, the sole American winner of the Nobel Prize in Chemistry was an immigrant, Joachim Frank, a Columbia University professor born in Germany. Immigrant Rainer Weiss, who was born in Germany and came to the United States as a teenager, was awarded the 2017 Nobel Prize in Physics, sharing it with two other Americans, Kip S. Thorne and Barry C. Barish. In 2016, all 6 American winners of the Nobel Prize in economics and scientific fields were immigrants. Table 1 U.S. Nobel Prize Winners in Chemistry, Medicine and Physics: 2000-2019 Category Immigrant Native-Born Percentage of Immigrant Winners Physics 14 19 42% Chemistry 12 21 36% Medicine 10 19 35% TOTAL 36 59 38% Source: National Foundation for American Policy, Royal Swedish Academy of Sciences, George Mason University Institute for Immigration Research. Between 1901 and 2019, immigrants have been awarded 35%, or 105 of 302, of the Nobel Prizes won by Americans in Chemistry, Medicine and Physics. -
Modeling Atomic Structure of the Emre Multidrug Pump to Design Inhibitor Peptides
PI: Karplus, Martin Title: Modeling atomic structure of the EmrE multidrug pump to design inhibitor peptides Received: 06/14/2013 FOA: PA11-262 Council: 01/2014 Competition ID: ADOBE-FORMS-B2 FOA Title: NIH SMALL RESEARCH GRANT PROGRAM (PARENT R03) 1 R03 AI111416-01 Dual: Accession Number: 3599020 IPF: 3212901 Organization: HARVARD UNIVERSITY Former Number: Department: Chemistry and Chemical Biology IRG/SRG: ZRG1 MSFD-N (08)F AIDS: N Expedited: N Subtotal Direct Costs Animals: N New Investigator: N (excludes consortium F&A) Humans: N Early Stage Investigator: N Year 1: Clinical Trial: N Year 2: Current HS Code: 10 HESC: N Senior/Key Personnel: Organization: Role Category: Martin Karplus Ph.D. Harvard University PD/PI Victor Ovchinnikov Ph.D Harvard University Co-Investigator Always follow your funding opportunity's instructions for application format. Although this application demonstrates good grantsmanship, time has passed since the grantee applied. The sample may not reflect the latest format or rules. NIAID posts new samples periodically: https://www.niaid.nih.gov/grants-contracts/sample-applications The text of the application is copyrighted. You may use it only for nonprofit educational purposes provided the document remains unchanged and the PI, the grantee organization, and NIAID are credited. Note on Section 508 conformance and accessibility: We have reformatted these samples to improve accessibility for people with disabilities and users of assistive technology. If you have trouble accessing the content, please contact the NIAID Office of Knowledge and Educational Resources at [email protected]. Principal Investigator/Program Director (Last, first, middle): Karplus, Martin Specific Aims Many aromatic compounds are used as antibiotic, antiseptic, and antineoplastic agents in the control of pathogens. -
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Introduction Have you ever seen those little About the International Year of Crystallography pictures of a molecule of your The United Nations declares 2014 as the official International Year of prescribed medication? …or a drawing Crystallography. It commemorates not only the centennial of X-ray of DNA showing two strands winding Amoxicillin diffraction, which allowed the detailed study of crystalline material, but also the 400th anniversary of Kepler’s observation in 1611 of the What do around each other? symmetrical form of ice crystals, which began the wider study of the role Molecules are too small to be seen by of symmetry in matter. New Drug Design, normal microscopy. Learn more at http://iycr2014.org X-ray crystallography is one of the DNA Studies few techniques that can visualize them About IUCr The International Union of Crystallography is a not-for- and was used to determine the first Schematic picture profit, scientific organization that aims to: and molecular structures ever known. of DNA • promote international cooperation in crystallography • contribute to all aspects of crystallography X-rays X-rays & X-ray Crystallography • promote international publication of crystallographic research have in common? How They Work • facilitate standardization of methods, units, nomenclatures and symbols • form a focus for the relations of crystallography to other sciences • X-ray beams are shot through • We calculate how the diffracted a crystal composed of the X-rays would look, if they The IUCr fulfils these objectives by publishing -
Interview with Harry B. Gray
HARRY B. GRAY (b. 1935) INTERVIEWED BY SHIRLEY K. COHEN SEPTEMBER 2000 – MARCH 2001 AND HEIDI ASPATURIAN JANUARY – MAY 2016 Photo taken in 1997 ARCHIVES CALIFORNIA INSTITUTE OF TECHNOLOGY Pasadena, California Subject area Chemistry Abstract Two interviews in seven and six sessions respectively, with Harry Gray, the Arnold O. Beckman Professor of Chemistry. The first series of interviews, conducted in 2000-01 with Shirley Cohen, deals with Gray’s life and career up to that time. The second series, conducted in 2016 with Heidi Aspaturian, covers the period 2001–2016, expands on a number of topics discussed in the first interview series, and adds to the account of Gray’s earlier decades. Discussion topics common to the two interviews are cross-referenced in both texts. 2000–01 Interview Gray opens this interview series with a description of his family roots and formative years in Kentucky’s tobacco-farming country, including his youthful career with the local newspaper and early interest in chemistry. He then provides an account of his undergraduate studies at Western Kentucky State College (BS 1957), graduate work with F. Basolo and R. Pearson at Northwestern University http://resolver.caltech.edu/CaltechOH:OH_Gray_H (PhD 1960), and postdoctoral work with C. Ballhausen at the University of Copenhagen, where he pioneered the development of ligand field theory. As a professor at Columbia University, he continued work at the frontiers of inorganic chemistry, published several books and, through an affiliation with Rockefeller University, was drawn to interdisciplinary research, which led him to accept a faculty position at Caltech in 1966. He talks about his approach to teaching and his research in inorganic chemistry and electron transfer at Caltech, his interactions with numerous Caltech personalities, including A. -
Nobel Special Issue of Chemical Physics Letters
Accepted Manuscript Editorial Nobel Special Issue of Chemical Physics Letters David Clary, Mitchio Okumura, Villy Sundstrom PII: S0009-2614(13)01325-0 DOI: http://dx.doi.org/10.1016/j.cplett.2013.10.045 Reference: CPLETT 31683 To appear in: Chemical Physics Letters Please cite this article as: D. Clary, M. Okumura, V. Sundstrom, Nobel Special Issue of Chemical Physics Letters, Chemical Physics Letters (2013), doi: http://dx.doi.org/10.1016/j.cplett.2013.10.045 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Nobel Special Issue of Chemical Physics Letters Editorial The hallmark of Chemical Physics Letters is the fast publication of urgent communications of the highest quality. It has not escaped our notice that this policy has allowed several of the breakthrough papers in chemistry to be published in our journal. Indeed, looking through Chemical Physics Letters over the last 42 years we found papers published by as many as 15 authors who went on subsequently to win the Nobel Prize in Chemistry for work linked to their articles. Furthermore, several of these papers were referenced in the Nobel citations. We thought our readers would find it of interest to see a collection of these papers brought together and introduced with summaries explaining their significance and written by the Nobelists themselves, close colleagues or editors of the journal. -
Development of Multiscale Models for Complex Chemical Systems
9 OCTOBER 2013 Scientifc Background on the Nobel Prize in Chemistry 2013 DEVELOPMENT OF MULTISCALE MODELS FOR COMPLEX CHEMICAL SYSTEMS THE ROYAL SWEDISH ACADEMY OF SCIENCES has as its aim to promote the sciences and strengthen their infuence in society. BOX 50005 (LILLA FRESCATIVÄGEN 4 A), SE-104 05 STOCKHOLM, SWEDEN Nobel Prize® and the Nobel Prize® medal design mark TEL +46 8 673 95 00, [email protected] HTTP://KVA.SE are registrated trademarks of the Nobel Foundation Scientific background on the Nobel Prize in Chemistry 2013 DEVELOPMENT OF MULTISCALE MODELS FOR COMPLEX CHEMICAL SYSTEMS The Royal Swedish Academy of Science has decided to award the 2013 Nobel Prize in Chemistry to Martin Karplus, Harvard U., Cambridge, MA, USA Michael Levitt, Stanford U., Stanford, CA, USA and Arieh Warshel, U. Southern Ca., Los Angeles, CA, USA For “Development of Multiscale Models for Complex Chemical Systems” 1 (10) Multiscale models for Complex Chemical Systems The Nobel Prize in Chemistry 2013 has been awarded to Martin Karplus, Michael Levitt and Arieh Warshel for development of multiscale models of complex chemical systems. Background Chemistry and Biochemistry have developed very rapidly during the last 50 years. This applies to all parts of the fields, but the development of Biochemistry is perhaps the most striking one. In the first half of these 50 years the determination of protein structure was perhaps the field where the largest efforts were spent and the largest progress was made. The standard methods to analyse the structure of proteins are X-ray crystallography of crystals or analysing the spin – spin couplings obtained from NMR-spectroscopy. -
Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013
PROFILE Profile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 Nobel Laureates in Chemistry Alan R. Fersht1 Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom You can read the Nobel Prize Web site for affectionately called “LMB,” thehomeof the best description of the science behind the Sydney Brenner, Francis Crick, John Ken- 2013 Nobel Prize in Chemistry. However, let drew, Aaron Klug, Cesar Milstein, Max me tell you what the beginnings of the sci- Perutz, and Fred Sanger—all now legends ence and its immediate impact were really in molecular biology. LMB was small and like–a personal account from a close by- overcrowded. Theoreticians were crammed stander and indirect collaborator in a neigh- side by side in small offices; experimentalists boring field who grew up scientifically with did not have offices, but sat at the end of the two of the laureates, and knows well the bench for paper work. Nobel laureates occu- third. The new laureates’ papers in the mid- pied tiny cubbyholes, and Sydney Brenner 1970s changed the way we think about pro- and Francis Crick shared a small office. We Michael Levitt. Credit: Linda A. Cicero/Stan- teins and set up a new area of science, which metallofthetimeincorridors,andinthe ford News Service. immediately and radically influenced and in- canteen for coffee, lunch, and tea. There spired me, along with many others. was continual cross-fertilization of ideas and The 1960s and 1970s were a time of great discussions among the different strands of timewasratheresotericandmainlyappealed excitement in the world of proteins. Their scientists. -
Development of Multiscale Models for Complex Chemical Systems from H+H2 to Biomolecules Nobel Lecture, December 8, 2013
Development of Multiscale Models for Complex Chemical Systems From H+H2 to Biomolecules Nobel Lecture, December 8, 2013 by Martin Karplus Department of Chemistry & Chemical Biology, Harvard University, U.S.A. and Laboratoire de Chimie Biophysique, ISIS, Université de Strasbourg, France. “Do not go where the path may lead, go instead where there is no path and leave a trail.” Ralph Waldo Emerson araphrasing Ralph Waldo Emerson, a 19th century New England philoso- P pher and essayist, I shall try to show in this lecture how I have gone where there was no path and lef a trail. It leads from trajectory studies of the reactions of small molecules to molecular dynamics simulations of macromolecules of biological interest. In developing computational methods to study complex chemical systems, the essential element has been to introduce classical concepts wherever possible, to replace the much more time-consuming quantum mechanical calculations. In 1929 [1] Paul Dirac (Nobel Prize in Physics, 1933) wrote (Fig. 1) the now familiar statement: Te underlying physical laws necessary for the mathematical theory of a large part of physics and the whole of chemistry are thus 63 6490_Book.indb 63 11/4/14 2:25 PM 64 The Nobel Prizes FIGURE 1. Quote from P.A.M. Dirac in 1929 (reference 1). completely known, and the difculty is only that the exact application of these laws leads to equations that are much too complicated to be soluble. However, the paragraph goes on to a less familiar part (Fig. 2): It therefore becomes desirable that approximate practical methods of applying quantum mechanics should be developed, which can lead FIGURE 2.