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Selective Ensembles in Supported Palladium Sulfide Nanoparticles For ARTICLE DOI: 10.1038/s41467-018-05052-4 OPEN Selective ensembles in supported palladium sulfide nanoparticles for alkyne semi-hydrogenation Davide Albani1, Masoud Shahrokhi2, Zupeng Chen1, Sharon Mitchell1, Roland Hauert 3, Núria López 2 & Javier Pérez-Ramírez1 Ensemble control has been intensively pursued for decades to identify sustainable alter- natives to the Lindlar catalyst (PdPb/CaCO3) applied for the partial hydrogenation of alkynes 1234567890():,; in industrial organic synthesis. Although the geometric and electronic requirements are known, a literature survey illustrates the difficulty of transferring this knowledge into an efficient and robust catalyst. Here, we report a simple treatment of palladium nanoparticles supported on graphitic carbon nitride with aqueous sodium sulfide, which directs the for- mation of a nanostructured Pd3S phase with controlled crystallographic orientation, exhibiting unparalleled performance in the semi-hydrogenation of alkynes in the liquid phase. The exceptional behavior is linked to the multifunctional role of sulfur. Apart from defining a structure integrating spatially-isolated palladium trimers, the active ensembles, the modifier imparts a bifunctional mechanism and weak binding of the organic intermediates. Similar metal trimers are also identified in Pd4S, evidencing the pervasiveness of these selective ensembles in supported palladium sulfides. 1 Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland. 2 Institute of Chemical Research of Catalonia (ICIQ), and The Barcelona Institute of Technology Av., Països Catalans 16, 43007 Tarragona, Spain. 3 EMPA, Swiss Federal Laboratories for Materials Science and Technology, Uberlandstrasse129, 8600 Dübendorf, Switzerland. These authors contributed equally: Davide Albani, Masoud Shahrokhi. Correspondence and requests for materials should be addressed to N.Lóp. (email: [email protected]) or to J.Pér-Rír. (email: [email protected]) NATURE COMMUNICATIONS | (2018) 9:2634 | DOI: 10.1038/s41467-018-05052-4 | www.nature.com/naturecommunications 1 ARTICLE NATURE COMMUNICATIONS | DOI: 10.1038/s41467-018-05052-4 he ultimate mission of researchers working in hetero- Liquid phase Gas phase geneous catalysis is the identification of active ensembles 1890 1930 1950 1970 1990 2010 T fi [1] with a high density to enable ef cient turnover while Pt black avoiding undesired intermolecular interactions, and exhibiting long-term stability to ensure a well-defined performance. Ni, Cu[2] Nevertheless, the fulfillment of all these requirements in one Pd catalytic material has yet to be accomplished, even for well- 1910 established reactions like heterogeneously-catalyzed hydrogena- tions studied since the 1880’s by Wilde, Sabatier, and 1,2 Senderens . Pd colloids[6] The chemo- and stereoselective hydrogenation of functiona- lized alkynes is a key catalytic transformation applied industrially PdPb at different scales, ranging from the gas-phase multi-ton pur- Ni[7] [8] ification of olefin streams for polymer manufacture3 to the Pd/diatomite Ni Raney[9`] smaller three-phase batch preparation of high-added-value fine chemicals4,5. Examination of the rich scientific literature emphasizes the wide dominance of palladium-based catalysts, due Alkali metals[10] to the ability to dissociate hydrogen, and the importance of [11] PdPb/CaCO3 preventing the undesired hydrogenation of competing functional Ag PdAg/Al O [12] groups through electronic poisoning with suitable modifiers 2 3 – Pd/BaSO + KOH[13] (Fig. 1)6 35. Similarly, oligomerization paths (C–C couplings) 4 must be suppressed by the strict control over the ensemble size. [14] – Pd/CaCO3 + SnCl2 Thus, the synthesis of trimeric ensembles36 39, and the presence of electronic modifiers reducing the hydrogen uptake of Pd and [15] the formation of subsurface hydrides, are key parameters for PdPb/CaCO3+ Bn2S achieving high selectivity both in gas- and three-phase operations. Pd-HHDMA Since 1952, the manufacture of building blocks for pharmaceu- ticals, vitamins, agrochemicals, and fragrances via alkyne semi- Pd/ZnO[16] hydrogenation4,40,41 has been conducted over the well-known lead- PdAu/TiO [18] poisoned palladium (5 wt.%) supported on calcium carbonate (Lin- c-Pd/C[17] 2 dlar catalyst), despite drawbacks of poor metal utilization and toxicity42,43. However, the recent disruptive legislations restricting the CuNiFe[19] CeO2 use of hazardous compounds have steered the innovation and PdGa[20] PdZn/ZnO[21] creativity of scientists towards the development of sustainable alter- Pd/TiO + Ph S[22] [25] 2 2 natives. This has enabled the incorporation of new families of Pd-HHDMA 1,2,7,9,10,30 Al Fe [23] hydrogenation catalysts based on: (i) alternative metals , (ii) Ce/TiO [27] 13 4 2 [24] 8,11–16,18–21 [28,29] Pd /Cu alloy and intermetallic compounds , (iii) ligand-modified PdB 1 6,17,22,25 26,27,34,35 Ag/SiO [30] [26] nanoparticles , (iv) transition metal oxides ,and(v) 2 CeO2 24,31,32 Pd@C N [31] Pd@C N supported single atoms . While these share better ensemble 3 4 [33] 3 4 [32] Pd4S/CNF definition than unmodified Pd, intrinsic drawbacks like instability Ag@C3N4 44–46 [34] against high pressure induced segregation for intermetallics , FeOx /ZrO2 fi Pd S/C N accessibility constraints in ligand-modi ed and single atom 3 3 4 In O [35] 31,47 48 2 3 catalysts , and poor H2 activation on oxides have been identified. In the search for new catalysts, very few works have studied the Pd S/C N modification with p-block elements22,28,29,49. In particular, sulfur- 3 3 4 modified Pd catalysts could be envisaged mimicking the strategy of ensemble and electronic density control in enzymes. In fact, Fig. 1 Survey of alkyne semi-hydrogenation catalysts. Chronological transition metal sulfides are applied for hydrotreating in oil development for gas- and liquid-phase applications tracing from the 1 2 6– refineries due to their resistance to poisons and ability toward H2 pioneering works of Wilde and Sabatier to the more recent discoveries activation50,51, and have also been studied for electrochemical 35. Six prominent catalyst families can be distinguished based on (i) 52 hydrogen evolution . Recently, a crystalline Pd4S phase was supported metal nanoparticles, (ii) intermetallics, alloys, and Lindlar-type shown to exhibit promising performance in the high pressure formulations where Pd is poisoned by a second metal, (iii) ligand-modified gas-phase hydrogenation of simple alkynes impurities in or hybrid materials featuring an organic surfactant that partially covers the petroleum-derived olefin streams, although no molecular-level surface of Pd nanoparticles, (iv) metal oxides, (v) supported single atoms, understanding was gathered33,53,54. Since the Pd-S phase diagram and (vi) Pd modified by p-block elements. The current industrially applied shows full mixing in all compositions and a continuum of closely catalysts are indicated in bold. Surface structures of representative related stable phases55, it offers room to tailor the active phase examples of each catalyst family are illustrated, highlighting the catalytic with the most selective ensemble and amount of electronic poi- ensemble soning at the atomic scale. By introducing a facile and scalable procedure to prepare alkynes. This is linked to the presence of trimeric metal ensem- crystal phase and orientation controlled Pd3S nanoparticles sup- fi ported on carbon nitride, this article demonstrates that sulfur can bles, which are also shown to be present in palladium sul des of play a multifunctional role enabling unparalleled hydrogenation different stoichiometry by the preparation and detailed inter- performance in the continuous-flow three-phase semi- rogation of the supported Pd4S phase. The superiority with hydrogenation of linear, internal, and bulky functionalized respect to other major families of hydrogenation catalysts is 2 NATURE COMMUNICATIONS | (2018) 9:2634 | DOI: 10.1038/s41467-018-05052-4 | www.nature.com/naturecommunications NATURE COMMUNICATIONS | DOI: 10.1038/s41467-018-05052-4 ARTICLE a Pd Pd3S Table 1 Properties of the catalysts studied Catalyst Pda/wt.% S b/ V c/ d d/nm D e/% Na S BET pore Pd CO 2 m2 g–1 cm3 g–1 T = 373–423 K Pd/C3N4 0.4 278 0.74 1.7 63 g Pd3S/C3N4- 0.4(1.9) 265 0.51 1.9 34 423f Pd4S/CNF 1.0 28 0.09 2.5 36 b PdPb/ 4.5 10 0.03 15 6 CaCO3 Pd-HHDMA 0.5 170 0.64 8.0 37 Pd@C3N4 0.5 155 0.26 0.4 — a 0123 0 1 2 3 ICP-OES bBET method d / nm d / nm c Pd Pd Volume of N2 adsorbed at p/p0 = 0.95 dTEM eCO chemisorption fTemperature of sulfidation in K gMolar Pd/S ratio, the sulfur content was determined by elemental analysis phases57, but this toxic and highly corrosive gas is synthetically c unattractive. Here, aqueous sodium sulfide was applied as an alternative, less widely studied sulfidation agent and the phase selectivity was monitored at different temperatures (Fig. 2a). Mesoporous graphitic carbon nitrite (C3N4) was targeted as a 0.250 nm carrier due to its well-known ability to stabilize palladium with 0.250 nm 31 high dispersion, including as single atoms (Pd@C3N4) , which was expected to facilitate the sulfidation treatment. Interestingly, despite exhibiting high stability in oxidative and reductive environments at elevated temperatures, tests in the temperature – range 373 423 K over Pd@C3N4 revealed that isolated palladium atoms were not stable against sulfidation treatments, transform- d ing into nanoparticles, as evidenced by scanning transmission 0.256 nm electron microscopy (STEM) (Supplementary Fig. 1a). For this reason, palladium was introduced via the wet deposition of pal- ladium chloride coupled with an additional sodium borohydride reduction step to promote the formation of palladium nano- 0246 8 – particles (Pd/C3N4) with an average diameter of 1 2 nm and a d / nm Pd very narrow size distribution. fi Analysis of the bulk properties of Pd/C3N4 and the sul ded analogs (Pd3S/C3N4-T, where Pd3S was the only crystalline phase identified and T = 373–473 K) confirmed the uptake of sulfur, absence of metal leaching, the negligible incorporation of sodium (< 2 ppm), and structural integrity of the carrier upon sulfidation Fig.
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