MFSD2A Antibody

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Product Datasheet MFSD2A Antibody Catalog No: #37724 Orders: [email protected] Description Support: [email protected] Product Name MFSD2A Antibody Host Species Rabbit Clonality Polyclonal Purification Antigen affinity purification. Applications WB IHC Species Reactivity Hu Specificity The antibody detects endogenous levels of total MFSD2A protein. Immunogen Type Peptide Immunogen Description Synthetic peptide corresponding to residues near the C terminal of human major facilitator superfamily domain containing 2A Target Name MFSD2A Other Names MFSD2 Accession No. Swiss-Prot#: Q8NA29NCBI Gene ID: 84879Gene Accssion: NP_001129965 SDS-PAGE MW 60kd Concentration 1.7mg/ml Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage Store at -20°C Application Details Western blotting: 1:500-1:2000 Immunohistochemistry: 1:25-1:100 Images Gel: 8%SDS-PAGE Lysates (from left to right): Human thyroid cancer tissue Amount of lysate: 40ug per lane Primary antibody: 1/250 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 1 Immunohistochemical analysis of paraffin-embedded Human brain tissue using #37724 at dilution 1/25. Background MFSD2 (major facilitator superfamily domain containing 2), also known as MFSD2A, is a 543 amino acid multi-pass membrane protein of the endoplasmic reticulum that is involved in beta-adrenergic signaling during thermogenesis. Existing as three alternatively spliced isoforms, MFSD2 plays a role in G1 regulation and is encoded by a gene that maps to human chromosome 1p34.2. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, ParkinsonΒ‘Β―s disease, Gaucher disease, schizophrenia and Usher syndrome. Note: This product is for in vitro research use only and is not intended for use in humans or animals. Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 2.

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Paleovirology of 'Syncytins', Retroviral Env Genes Exapted for a Role in Placentation
Paleovirology of ‘syncytins’, retroviral env genes exapted for a role in placentation Christian Lavialle1,2, Guillaume Cornelis1,2, Anne Dupressoir1,2, Ce´cile Esnault1,2, Odile Heidmann1,2,Ce´cile Vernochet1,2 1,2 rstb.royalsocietypublishing.org and Thierry Heidmann 1UMR 8122, Unite´ des Re´trovirus Endoge`nes et E´le´ments Re´troı¨des des Eucaryotes Supe´rieurs, CNRS, Institut Gustave Roussy, 94805 Villejuif, France 2Universite´ Paris-Sud XI, 91405 Orsay, France Review The development of the emerging field of ‘paleovirology’ allows biologists to reconstruct the evolutionary history of fossil endogenous retroviral sequences Cite this article: Lavialle C, Cornelis G, integrated within the genome of living organisms and has led to the retrieval of conserved, ancient retroviral genes ‘exapted’ by ancestral hosts to fulfil Dupressoir A, Esnault C, Heidmann O, essential physiological roles, syncytin genes being undoubtedly among the Vernochet C, Heidmann T. 2013 Paleovirology most remarkable examples of such a phenomenon. Indeed, syncytins are of ‘syncytins’, retroviral env genes exapted for a ‘new’ genes encoding proteins derived from the envelope protein of endogen- role in placentation. Phil Trans R Soc B 368: ous retroviral elements that have been captured and domesticated on multiple 20120507. occasions and independently in diverse mammalian species, through a pro- http://dx.doi.org/10.1098/rstb.2012.0507 cess of convergent evolution. Knockout of syncytin genes in mice provided evidence for their absolute requirement for placenta development and embryo survival, via formation by cell–cell fusion of syncytial cell layers at One contribution of 13 to a Theme Issue the fetal–maternal interface.
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Polyclonal Antibody to MFSD2 (C-Term) - Aff - Purified
OriGene Technologies, Inc. OriGene Technologies GmbH 9620 Medical Center Drive, Ste 200 Schillerstr. 5 Rockville, MD 20850 32052 Herford UNITED STATES GERMANY Phone: +1-888-267-4436 Phone: +49-5221-34606-0 Fax: +1-301-340-8606 Fax: +49-5221-34606-11 [email protected] [email protected] AP26290PU-N Polyclonal Antibody to MFSD2 (C-term) - Aff - Purified Alternate names: HMFN0656, Major facilitator superfamily domain-containing protein 2, PP9177 Quantity: 0.1 mg Background: Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis. Uniprot ID: Q8NA29 NCBI: NP_001129965 GeneID: 84879 Host: Rabbit Immunogen: 18 amino acid peptide near the carboxy terminus of human MFSD2A Format: State: Liquid Ig fraction Purification: Affinity chromatography purified via peptide column Buffer System: PBS containing 0.02% sodium azide Applications: ELISA. Western blot: 1 - 2 µg/ml. Positive control: Lung Tissue Lysate.
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Suppressyn Localization and Dynamic Expression Patterns in Primary Human Tissues Support a Physiologic Role in Human Placentation Jun Sugimoto1,4,5*, Danny J
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