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Polyclonal Antibody to MFSD2 (C-Term) - Aff - Purified

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Polyclonal Antibody to MFSD2 (C-Term) - Aff - Purified OriGene Technologies, Inc. OriGene Technologies GmbH 9620 Medical Center Drive, Ste 200 Schillerstr. 5 Rockville, MD 20850 32052 Herford UNITED STATES GERMANY Phone: +1-888-267-4436 Phone: +49-5221-34606-0 Fax: +1-301-340-8606 Fax: +49-5221-34606-11 [email protected] [email protected] AP26290PU-N Polyclonal Antibody to MFSD2 (C-term) - Aff - Purified Alternate names: HMFN0656, Major facilitator superfamily domain-containing protein 2, PP9177 Quantity: 0.1 mg Background: Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis. Uniprot ID: Q8NA29 NCBI: NP_001129965 GeneID: 84879 Host: Rabbit Immunogen: 18 amino acid peptide near the carboxy terminus of human MFSD2A Format: State: Liquid Ig fraction Purification: Affinity chromatography purified via peptide column Buffer System: PBS containing 0.02% sodium azide Applications: ELISA. Western blot: 1 - 2 µg/ml. Positive control: Lung Tissue Lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Specificity: This antibody detects MFSD2 at C-term. Species Reactivity: Tested: Human, mouse, rat Storage: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. General Readings: 1. Fluman N, Bibi E. Bacterial multidrug transport through the lens of the major facilitator superfamily. Biochim Biophys Acta. 2009 May;1794(5):738-47. doi: 10.1016/j.bbapap.2008.11.020. Epub 2008 Dec 7. PubMed PMID: 19103310. 2. Law CJ, Maloney PC, Wang DN. Ins and outs of major facilitator superfamily antiporters. Annu Rev Microbiol. 2008;62:289-305. doi: 10.1146/annurev.micro.61.080706.093329. PubMed PMID: 18537473. 3. Spinola M, Falvella FS, Colombo F, Sullivan JP, Shames DS, Girard L, et al. MFSD2A For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20160219 1 / 3 AP26290PU-N: Polyclonal Antibody to MFSD2 (C-term) - Aff - Purified is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment. Mol Cancer. 2010 Mar 17;9:62. doi: 10.1186/1476-4598-9-62. PubMed PMID: 20236515. 4. Angers M, Uldry M, Kong D, Gimble JM, Jetten AM. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem J. 2008 Dec 15;416(3):347-55. doi: 10.1042/BJ20080165. PubMed PMID: 18694395. Pictures: Western blot analysis of MFSD2A in rat lung tissue lysate with MFSD2A antibody at (A) 1 and (B) 2 ug/mL. Immunohistochemistry of MFSD2A in rat lung tissue with MFSD2A antibody at 5 ug/mL. For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20160219 2 / 3 AP26290PU-N: Polyclonal Antibody to MFSD2 (C-term) - Aff - Purified Immunofluorescence of MFSD2A in Rat Lung cells with MFSD2A antibody at 20 ug/mL. For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20160219 3 / 3 Powered by TCPDF (www.tcpdf.org).
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