XXXXXX 2014 PROGRESS REPORT 1 2014 XXXXX PROGRESS X REPORT
DARE TO LOOK BEYOND THE HORIZON 2014 PROGRESS REPORT 3 TABLE OF CONTENTS
A Word from the Director 4
A Word from the Scientific Director 5
2013-2018 Strategic Research Plan 6 to 11
Discovery and Hope 12 to 17
The New CHUM Research Centre 18 and 19
The Student Environment: Excellence in the Next Generation 20 and 21
Philanthropy: Supporting Speculative Research and the Next Generation 22 and 23
2013-2014 Financial Picture 24 and 25
Our Committees 26
SEEK OUT WHAT OTHERS FEAR TO TREAD
Premiers arrivants Designed expressly to overhang the FRANÇOIS VINCENT CRCHUM entrance hall, this work Painter pays homage to a more sensitive Materials: oil on panels fastened to approach to life. Its simplicity for- hardwood (ash) uprights sakes the complexity of science and Dimensions: 5 panels measuring its grandeur invites the passer-by to 1.4 m. x 1.7 m., the entire piece take a moment to contemplate and measures 5.1 m. in all and is hung look into oneself. 1.8 m. above the ground.
This work was chosen within the framework of the Government’s policy geared towards integrating the arts into the architecture and built environ- ment of Government and public sites, which compels any organization that receive grants from the State to set aside at least 1% of their budget to create or purchase works of art. 4 A WORD FROM 2014 PROGRESS REPORT 5 A WORD THE DIRECTORS FROM THE DIRECTORS
A WORD FROM A WORD FROM THE THE DIRECTOR SCIENTIFIC DIRECTOR
fter six years of tho possibilities for meaningful exchan- of direct investment made by the he past few years have devotion and passion. They include continuum that characterizes us. rough methodical plan- ges arise daily and participation in Government of Quebec. Over the been transformative researchers, members of our per- The plan also provides several ning and a smoothly numerous conferences in a variety past five years, the CRCHUM bud- and prolific ones for sonnel, students and trainees who strategic initiatives to recruit lea- completed construction of areas is now more than possible. get has erased all previous accumu- the CRCHUM. To begin are conducting innovative research ding world-class researchers, two phase, the CRCHUM lated deficits and now boasts a capi- with, in 2013, we moved projects that are closely linked to of whom have already been suc- Aopened its doors in the fall of 2013. Today, the CRCHUM gives us great tal fund of $4.8 million, in addition Tinto a new complex right in the the health of both individuals and cessfully hired. Accordingly, the Seeing as this project was indispen- pride that all of its researchers wish to a balanced annual budget. heart of Montreal. Naturally, our populations. CRCHUM has reinforced its criti- sable for the continued development to expose to the rest of the world. physical environment is a neces- cal mass in several fields of excel- and outreach mission of our ins- This feeling is embodied by the Dear readers, it gives me immense sary prerequisite to our success, The CRCHUM Scientific Commit- lence, including viral and chronic titution, we very effectively “got it recurring commitment of its stu- pleasure that we may present to you but it is clearly insufficient by itself. tee undertook a comprehensive diseases, translational cell biology right”. The result: our path has been dents, personnel and researchers some of the CRCHUM’s more signi- What make our centre stand out reflection regarding its strengths, and imaging, by recruiting excep- unblemished. The Centre was com- to various fundraising activities. ficant achievements. are all the wonderful people who its focal research themes and its tional researchers from prestigious pleted on time and on budget and For a fifth year now, the CRCHUM come to work there every day with development priorities. This reflec- institutions such as Harvard Medi- now provides technical facilities on Challenge has provided the means tion culminated in cal School and University College the cutting edge of the most modern to raise substantial amounts of the drafting of our London. technologies to more than nineteen money that are redirected towards 2013-2018 Scienti- hundred researchers, students and both student and personnel activi- After six years of thorough fic Plan, which sets Firmly entrenched in its vision of members of the Centre’s personnel. ties. The Grand Labo, that will be Jacques Turgeon out certain goals excellence, the CRCHUM is affir- marking its fifth edition in 2014, B.Pharm, PhD methodical planning and and targets for the ming its place as a major North This new edifice was more than ne- provides an occasion to attract win- Director of the next five years. The American research establishment cessary. Over the past few years, the ners of the Nobel Prize in Medicine CHUM Research Centre a smoothly completed research themes within its university hospital, its CRCHUM has experienced conside- every year, and thereby foster and have been remodel- status as a flagship for the Univer- rable growth in terms of the number fulfil the CRCHUM’s international construction phase, the led, our strengths sité de Montréal Faculty of Medi- of researchers and grants received. potential. This research potential in imaging and cine and its role as a partner who It was morally bound to make the is dedicated to pursuing one single CRCHUM opened its doors engineering have is firmly committed to all of Quebec most of pooling its various areas objective: namely, enabling patients in the fall of 2013. This been consolidated society. We can all be proud. of expertise by bringing together in the Province of Quebec to be the into a new research the different teams who had pre- first to enjoy access to and benefit capital project to develop theme and a matrix viously been scattered over six dif- from cutting edge treatments. structure that fos- ferent sites. Once it was officially and boost the outreach of ters cross-fertili- announced, this project promptly The CRCHUM is also an economic zation between the generated the dynamic that was engine for the Montreal area. With the institution was carried various disciplines eagerly awaited and hoped for by an annual budget of $75 million, it has been adopted to Vincent Poitout all the researchers. Since then, col- helps attract foreign credits, by a out very effectively and we better sustain and D.V.M., PhD laborative projects are flourishing, ratio of five to one, for every dollar “got it right”. The result: nurture the research Scientific Director our path has been unblemished. 6 2013-2018 STRATEGIC 2014 PROGRESS REPORT 7 2013-2018 RESEARCH PLAN STRATEGIC RESEARCH RECONFIGURATION OF THE PLAN FOCAL RESEARCH THEMES THOROUGHLY DANIEL KAUFMANN, MD, INTERRELATED CRCHUM RESEARCHER PRIORITIES To move forward, CRITICAL CRCHUM management has elaborated a 2013-2018 Strategic Research Plan that introduces several major changes. The CRCHUM has chosen to focus one has to work its research priorities on eight specific research themes that are interrelated between one another, so as to create an amalgam of expertise that is perfect- with the best, not POSITIONING ly complementary. The Centre’s research themes have thus been remodel- led in order to develop a critical mass of multidisciplinary expertise in the only in one’s own targeted fields, thereby corresponding to the CHUM’s areas of excellence. research field, but ON THE The priorities that were retained will help entrench even more thoroughly also with other the links between basic, clinical, and population health research activities, while fostering the development of emerging themes. The creation of an specialists. After applied Clinical Research Unit will consolidate clinical and epidemiological WORLD STAGE research. Since the research themes function vis à vis one another as a ma- several years at trix, some of them will explore the specific components of a given pathology, while others will concentrate on transversal approaches. This new vision Harvard, I deci- will thus decompartmentalize various areas of expertise, and now provide the 435 researchers with a unique and high-performance framework that ded to join the CANCER CARDIO- TISSUE INJURY, NEURO- fosters interdisciplinary collaboration. CRCHUM for the METABOLIC IMMUNITY, SCIENCE › Solid tumours INFECTION interrelatedness CRCHUM’S (ovary, breast, › Diabetes and AND INFLAM- › Neuro- prostate, neck) hypertension MATION immunology of the different RESEARCH › Biomarkers › Personalized › Neuro- medecine › Arthrosis and degeneration auto-immunity research themes, PRIORITIES › Aging › Neuro-genetics › Organ transplan which pool a uni- tation and donation › Chronic viral que amalgam of diseases expertises.” IMAGING AND › Morpho-functional and physical imaging and modelling of biological systems ENGINEERING › Image-guided medical acts › Design, development and validation of new biomaterials and implants Daniel Kaufmann is a physician scientist whose research addresses the human immunodeficiency RISKS Etiological epidemiology: Risks factors › virus (HIV) and the regulation TO HEALTH of the body’s immune system. An internal medicine and GLOBAL HEALTH › Vulnerability and health infectious disease specialist, he has notably worked in EVALUATION, › Health promotion, Chronic disease prevention and management Switzerland, as well as at the CARE SYSTEMS › Improving healthcare delivery prestigious Harvard University. AND SERVICES › Evaluative research ACRU AND CORE FACILITIES 8 PLAN2014 DE PROGRESS RECHERCHE REPORT 2013-2018 STRATEGIC 2013-2018 STRATEGIC 2014 PROGRESS REPORT 9 STRATÉGIQUE 2013-2018 RESEARCH PLAN RESEARCH PLAN
FOCUS POOLING STATE UPON OF THE ART EMERGING TECHNOLOGY SECTORS PLATFORMS
The CRCHUM has In order to implement a genuine concentration of knowledge and excellence that truly creates a unique synergy where everyone identified emerging sectors rubs shoulders together, the CRCHUM took the initiative of poo- in such a way as to cultivate ling its researchers’ equipment. Accordingly, each of them now and nurture the critical has access to 10 cutting edge technology platforms in order to ad- mass and expertise linked vance and develop innovative applications. The CRCHUM thus shoulders 50% of the cost of equipment maintenance and upgra- to these sectors des, while researchers use part of their research funds to pay the fees associated with using the equipment based upon what their research work requires. This user pays principle hence enables all researchers to now have access to their colleagues’ equipment THE SERIOUS and platforms on the cutting edge of the most modern technology. BURN CLINICAL VICTIMS Animal facility RESEARCH Biobanks UNIT Genomics and genotyping WELCOMES Biostatistics ITS FIRST PAIN Cytometry, cell imaging PATIENTS and molecular pathology The Clinical Research Unit phase 1 Experimental Imaging and 2 is a rarity in its category in COMPARE OURSELVES SO North America and plays a key role AS TO PUSH THE ENVELOPE BioSafety Level 3 (BSL3) in giving the CRCHUM its creden- tials and reputation. With a capa- CRCHUM management has created a Scientific Rodent phenotyping city of 15 beds, it provides a place to Advisory Committee of international renown to study new treatments and to deter- evaluate the Centre’s performance. The goal: › Metabolic phenotyping mine with what kind of patients they raise the CRCHUM into the category of the most ADDICTION › Cardiovascular phenotyping might be effective. Thanks to the competitive research centres in the world. The › Behavioral phenotyping convergence of an advanced exper- members of the committee will visit the Centre tise in research and in 3rd line ter- every two years and make recommendations to Mass spectrometry and surface tiary care and access to an immense CRCHUM management with a view towards refi- plasmon resonance pool of patients from the CHUM, it ning the Strategic Plan so that the Centre’s quality is feasible to conduct clinical trials standards reach the highest possible level. › Metabolomics and cellular physiology with healthy volunteer subjects › Pharmacokinetics (phase 1) and volunteer patients THE MEMBERS OF THIS COMMITTEE ARE: › Surface plasmon resonance (phase 2). Last April 24, the per- › Dr. Marc G. Caron, Duke University MEDICALLY- sonnel in the unit welcomed its first › Dr . Jean-Laurent Casanova, ASSISTED Gene targeting and animal modelling two patients, as part of a clinical trial Rockefeller University REPRODUC- supervised by Dr. Claire Fournier, a and Université Paris Descartes TION CHUM hepatologist. › Dr. Pierre Corvol, Collège de France › Dr . Marcel Goldberg, Université de Versailles, Saint-Quentin-en-Yvelines 10 2014 PROGRESS REPORT 2013-2018 STRATEGIC 2013-2018 STRATEGIC 2014 PROGRESS REPORT 11 RESEARCH PLAN RESEARCH PLAN
THE CYCLOTRON THE RESEARCH CONTINUUM
A CLEAR STRATEGIC The CRCHUM cyclotron is a state of the art piece of equipment that produ- H ces radioactive atoms that can be used to treat cancer, as well as for research IC C R C S R E L DIRECTION JEAN DASILVA, PHD, development in the area of imaging. The proximity between the cyclotron A A S IN B E E S I CRCHUM RESEARCHER and the imaging facility located in the animal facility is a major asset that A C With its 48,000 m2 of research space, the CRCHUM is E R A will help develop new markers. In addition, a pneumatic conveyer system R one of the most impressive research centres in North Ame-
C
L TRANSLA-
between the CRCHUM and the CHUM will provide a way to rapidly trans- rica. Under one roof, it houses a comprehensive research H
TIONAL
mit new markers matched with isotopes that have a very short life span, continuum, which includes population health, basic and
“It’s rare to find RESEARCH
thereby opening up a whole new field of diagnostics built upon using cer- clinical research. The research continuum is a major asset,
G
tain isotopes that until now would have been difficult to employ. There are e n which will accelerate the translation of scientific knowled- o a research n i e t very few research institutions that are equipped with such a high calibre a ge and help better take charge of individuals who require z | i
P P n institution that apparatus, which makes the CRCHUM a most sought after centre by resear- a treatment. It represents the cornerstone of the Centre’s r H o O g t E r chers in the imaging theme. e P o scientific development plan. The CRCHUM’s strategic i A U N n L LATIO re boasts both T a plan stipulates transforming the research continuum into | H H c C C e RESEAR th ll al a genuine competitive advantage, by optimizing collabo- s e a radiochemistry | A | H ration in the primary research themes in order to make ni ts mal ien lab and a cyclo- modelling | Pat major discoveries, which will differentiate the Centre. To do this, three key interrelated elements have been adopted tron dedicated as guiding principles: a clear scientific statement, access to the necessary resources and active partnerships with to research. For other research centres. a radiochemistry researcher, access STRATEGIC RECRUITMENT to this exceptio- The deployment of the scientific development plan requires that we recruit leading, high performance, mid-career nal technological researchers. The CRCHUM has set itself the goal of strategically recruiting five individuals in its 2013-2018 plan. At the end of the present fiscal year, two such individuals have indeed been recruited. Our targets in terms of the platform lowers next generation are similarly geared towards our research priorities. barriers and opens up brand Translational Cell Biology COMPLETED Recruitment of Greg FitzHarris, previously new horizons.” a researcher at the University College London, a leading authority with regard to fertilization and oocyte and embryo biology.
Jean DaSilva was Head of the Imaging and positron emission tomography COMPLETED Radiochemistry Department at (PET): radiochemist associated with the new Recruitment of Jean DaSilva, a leading international the National Cardiac PET Centre CRCHUM cyclotron authority in radiochemistry and previously a researcher at the University of Ottawa. at the University of Ottawa Cardiology Institute. Recognized around the world as a leading light in radiochemistry, this renowned authority in the Population and clinical studies: UNDER WAY domain is directing avant-garde methodology/epidemiology/biostatistics work in translational research. Cancer: breast, ovarian or prostate UNDER WAY cancer research
Diabetes: clinical research in diabetes UNDER WAY and metabolic diseases 12 DISCOVERY DISCOVERY 2014 PROGRESS REPORT 13 AND HOPE A FEW DISCOVERIES BREAKING
Over the past few years, CRCHUM researchers DOWN have distinguished
themselves by extending Daniel Kaufmann, Andrés Finzi, Julie Bruneau, MD, a researcher PhD, a researcher MD, MSc., the frontiers of science. in the Tissue injury, in the Tissue injury, BARRIERS a researcher in the infection, immunity and infection, immunity and Risks to health research inflammation research inflammation research theme and co author Theme and project domain and project of the study co-director co-director
DNA reprogramming A better Methadone reduces to counter understanding the risk of HIV the AIDS virus of the early stages transmission A research team reveals how HIV of the AIDS Thanks to an international study, neutralizes immune cells. This im- solid existent evidence is now de- portant discovery could well pave virus infection monstrating that opiate substitu- the way towards genetically repro- A CRCHUM team has published tion therapies are effective in redu- gramming the immune cell’s DNA two studies that convincingly reject cing the risk of HIV transmission Manon Choinière, Marc Prentki, John Stagg, PhD, PhD, a researcher in order to boost its capacity to fight our understanding of the mecha- amongst injection drug users. PhD, a researcher in a researcher in the in the Evaluation, care the Cardiometabolic Cancer research off HIV. nisms by which HIV-1 enters the systems and services research theme and theme and body. The results of this research research theme and project leader project leader project leader study are crucial, not only because they are likely to point towards new therapeutic targets, but also becau- se they could help guide the design A novel drug Chronic A breakthrough of more effective vaccines. target linked to postoperative pain: in the fight against OUR RESEARCHERS’ insulin secretion a necessary evil? triple-negative PUBLICATIONS and type 2 diabetes About 10% of patients who undergo breast cancer Breakthrough heart surgery experience chronic treatment postoperative pain for a period that A team of researchers in the identification CRCHUM researchers have dis- can last up to two years after sur- have discovered that 900 of the multiple covered a new enzyme, ABHD6, gery, according to a vast multi-cen- an enzyme in triple- linked to insulin secretion in the tre study. This study paves the way negative breast can- publications sclerosis mechanisms blood. This discovery could lead to towards rendering a better follow cer makes patients on average per year* A team of researchers has shed the development of effective drugs up of patients who suffer postope- less responsive to light on blood-brain-barrier func- for treating type 2 diabetes. rative pain, that is not insignificant. chemotherapy. This tioning and the mechanisms used important discove- by the brain to naturally defend ry opens the door to 5 itself against attacks to the immune new treatments for publications per system, such as multiple sclerosis. patients with this Alexandre Prat, regular researcher MD, PhD, FRCPC, particularly virulent a researcher in the form of cancer. per year Neuroscience research theme and project * Listed on PubMed co-director 14 2014 PROGRESS REPORT DISCOVERY HOPE 2014 PROGRESS REPORT 15
A FEW PROJECTS
DR. FRANÇOISE BARRÉ-SINOUSSI, WINNER OF THE 2008 NOBEL PRIZE IN MEDICINE TO INSPIRE HOPE What gives me the most pleasure? Going to Stockholm to receive the Nobel Prize in
Pavel Hamet, Nicola Janusz OQ, MD, PhD, Medicine or, when the Nobel Hagemeister, Kaczorowski, MA, FRCPC, FCAHS, FRSM, Eng, PhD, a researcher PhD a researcher in the a researcher in the in the Imaging and Evaluation, care systems Cardiometabolic engineering theme and services research research theme and and project theme and project lead project co-director co-director Prize is announced, receiving investigator
messages from patients from The Opti-Thera Better diagnoses A knowledge network project: better and treatments for front line care prevention to fight of osteoarthritis, and services in the the 1980s who congratulate me type 2 diabetes a healthcare system Province of Quebec The Opti-Thera project seeks to priority The knowledge network for front foster the development of a per- line care and services in the Pro- and who say to me “we’re still sonalized approach to medicine Nicola Hagemeister pilots a large-sca- vince of Quebec seeks to boost the in the Province of Quebec so as to le research project that seeks to im- capacity for countering fundamental better prevent certain diseases and prove the diagnoses and management problems related to ageing, mental identify more effective treatments of osteoarthritis of the knee and to re- health and chronic disease. here and we thank you”. ” to deal with certain pathologies, duce the direct and by adapting pharmacotherapy to indirect costs lin- the patient based upon the latter’s ked to this disease. genetic information. The MonArthrose. Guest of Honour at the 2010 CRCHUM Grand Labo, Dr. Françoise Barré-Sinoussi played a key role, in 1983, EXCEPTIONAL in the discovery of the HIV that causes AIDS. She is the recipient of the 2008 Nobel Prize in Medicine. ca program makes HONORS use of a personali- zed treatment plan adapted to each In 2012 the CRCHUM patient’s condition, was attributed the score in contrast to the usual practice that “exceptional”, the highest takes a more gene- one possible, by the ric approach. Fonds de recherche du Québec – Santé. 16 2014 PROGRESS REPORT HOPE HOPE 2014 PROGRESS REPORT 17
DR. FERID MURAD, WINNER OF THE 1998 NOBEL PRIZE IN MEDICINE
Marie-Josée If I went into Hébert, MD, Patrick Cossette, Jennifer Fred Saad, a researcher in the MD, PhD, O’Loughlin, MD, FRCSC, Tissue injury, infection, a researcher in the M Sc, PhD, a researcher a researcher in the immunity and Neuroscience research in the Risks to health Cancer research inflammation research theme and project research theme and theme and medicine, I would theme and co-director project leader project leader project leader
Creation of a Diagnostic tests Take action to help What kinds have helped about unique pan-Canadian linked to drug- adolescents stop of prostate cancer research network resistant epilepsy smoking require immediate 2,000 or 3,000 peo- treatment? A unique network in the whole Diagnostic tests linked to drug-re- A team of researchers has received world, the Canadian National Trans- sistant epilepsy seek to more easily two subsidies totalling $1.2 million A cross-Canada network of prostate plant Research Program will help identify patients who are likely to from the Canadian Cancer Society cancer researchers are seeking to ple. Because of my stimulate innovation in research and respond better to alternative thera- to conduct a study that seeks to es- identify the significant biomarker generate many positive benefits for pies. These diagnostic and clinical tablish a program to quit smoking combinations, used with existing patients in terms of organ and cell guidelines could represent annual that will be especially designed for clinical tools, which will help better research, I have donation and transplants. savings of nearly $12 million for the adolescents from 12 to 17 years old. evaluate the probable progression Canadian healthcare system. of early stage tumours before and after treatment. The study could reduce the disease’s recurrence been able to help and improve the quality of life of A new initiative to change the men who are affected by it. how ovarian cancer is diagnosed millions of people and managed in the world Women all over the world will be able to benefit from and I hope that they the cross-Canada multi-institutional program on ova- rian cancer, that goes by the name of CŒUR, which seeks to change how ovarian cancer is diagnosed and will be able to help managed. The study will try to identify new biomarkers for screening and treating this relatively rare, but often fatal form of cancer. Anne-Marie Mes-Masson, PhD, millions more.” and Diane Provencher MD, FRCSC, FACOG, both researchers in the Cancer research theme and are co-directors These were the words that Dr. Ferid Murad, winner of the of the project 1998 Nobel Prize in Medicine, addressed to the 500 guests who attended the 2012 CRCHUM Grand Labo. 18 THE NEW CHUM 2014 PROGRESS REPORT 19 THE NEW RESEARCH CENTRE CHUM RESEARCH THE INFRASTRUCTURE CENTRE AND FACILITIES 48,000 square meters of new AN IMPORTANT facilities on the cutting edge of technology in a complex measuring MILESTONE IN 68,000 square meters THE CRCHUM’S 13 2013 marks an important milestone in the CRCHUM’s football fields in terms history. After 40 months of construction work and some $469.5 million coming from a public-private par- of its total surface tnership, the CRCHUM was inaugurated on October 8, HISTORY 2013. Built in the very heart of the new Montreal Health Care District, it is one of the largest integrated research centres operating in a hospital setting in America, and one of the very first to bring under one roof basic, clini- 75 cal and population health research activities. 735 laboratories professionals, THE TEAMS support staff, AND TALENT technicians and research nurses 1 180 MeV cyclotron and trainees a ultra-modern medical This 40-month project was carried out as a public- imaging platform private partnership initiative and was delivered on time and without any cost overruns. Built according to LEED silver certification norms, it constitutes 1,900 the kick-off to the first phase of the overall CHUM people modernization project. 10 work there specialized platforms A PROJECT THAT HAS RECEIVED VARIOUS AWARDS › Recipient of the 2012 Investment Infrastructure Award in the “Best social project” category, 36 470 awarded by the London-based financial magazine clinical examination rooms graduate World Finance. and postdoctoral › Winner of the 2014 Real Estate Excellence Award students in the “Best commercial real estate project” category, in the course of the Montreal 435 Real Estate Summit. 15 researchers phase l beds 20 THE STUDENT 2014 PROGRESS REPORT 21 THE STUDENT ENVIRONMENT ENVIRONMENT CRCHUM SCHOLARSHIPS
Various CRCHUM scholarships, funded notably with some of the monies raised through charitable activities, are geared towards supporting gra- duate and post-graduate students. PhDs can also receive scholarships to HASNA MAACHI, MSC, help them undertake postdoctoral research training at the CRCHUM. CRCHUM STUDENT
EXCELLENCE IN THE NOBEL PRIZE GUESTS I decided to conti- OF HONOUR EVERY YEAR nue my education NEXT GENERATION at the CRCHUM 2013 Dr. Jules Hoffmann, winner of the 2011 Nobel Prize in Medicine owing to its state
The CRCHUM welcomes more than 2012 Dr. Ferid Murad, winner of the 1998 Nobel Prize in Medicine of the art tech- 470 graduate and post-graduate 2011 Dr. Lee Hartwell, winner of the 2001 Nobel Prize in Medicine nology platforms medical research students. Given its association with the Université 2010 Dr. Françoise Barré-Sinoussi, and its modern de Montréal, the Number One tea- winner of the 2008 Nobel Prize in Medicine ching and research pole in the Pro- research environ- vince of Quebec and the 2nd biggest student body in Canada, there thus ment. Numerous exists a veritable wealth of talent. In addition, with the Université de meetings and Montréal Faculty of Medicine, the conferences are a 3rd biggest in North America and where the excellence of its projects crucially important submitted generates more than 60% of the research funds in the part of my training form of subsidies, the CRCHUM is duty-bound to create and sustain a and push me training environment conducive to the highest quality of learning, to to see beyond thereby cultivate a promising and certain disciplinary committed new generation dedica- ted to research excellence. boundaries.”
The basic, clinical and population health research laboratories, cou- Hasna Maachi completed her pled with an integrated teaching CRCHUM SYMPOSIUMS AND CONFERENCES Masters degree at the CRCHUM, and training centre, enable the stu- STIMULATING AND where she worked on a renal dents to simulate clinical interven- proximal tubule apoptotic pro- tions and thereby acquire expertise WORLD-RENOWNED tein. A student of the CRCHUM in state of the art areas, alongside FORUMS FOR SCIENTIFIC since January 2014, she has world-renowned researchers. EXCHANGE AND DIALOGUE decided to do her Doctorate in Pharmacology at the Université Following the example of many major research de Montréal Faculty of Medicine institutions all around the world, the CRCHUM and is working in the laboratory organizes prestigious conferences hosted by of Vincent Poitout, the CRCHUM Scientific Director. She is looking scientist-speakers coming from a wide variety of into the proliferation of cells in disciplines. The originality of this formula has nu- A student proudly presents her research project human islets of Langerhans. merous benefits, notably with regard to training to the winner of the Nobel Prize in Medicine, Dr. Jules Hoffmann. students who are thus able to interact at very clo- se range with many highly regarded researchers. 22 PHILANTHROPY PHILANTHROPY 2014 PROGRESS REPORT 23
DR. LEE HARTWELL, WINNER OF THE 2001 NOBEL PRIZE IN MEDICINE I share the CRCHUM’s commitment, a real world centre for exciting medical research, to allow young CRCHUM CHALLENGE SUPPORTING people to have OVER Organized in co-operation with the Fondation du THE YEARS… crazy ideas and CHUM, the CRCHUM Challenge is a charitable activi- SPECULATIVE More than try imaginative ty that invites people to raise money for a run or walk to be done in support of research. things. Because The donations thus collected RESEARCH are notably redistributed $2.5M most research as professional develop- OVER ment scholarships for THE YEARS… has been raised as a result funding is very postdoctoral fellows AND THE NEXT of the Grand Labo, and trainees at the More than since 2010. conventional, it’s CRCHUM, to ena- ble them to play a GENERATION very hard to test role in our research $350,000 crazy ideas. But if and in improving as been raised as Certain research projects, that ne- PUTTING THE health care for the a result of the vertheless pass the test of excellen- THE CRCHUM they turn out to entire population. ce, do not necessarily respond to the FUNDS TO WORK CRCHUM Challenge, visions or inclinations of various GRAND LABO › Postdoctoral training be right, it chan- since 2010. subsidizing bodies. Unconventio- The CRCHUM Grand Labo is a co- scholarship fund ges the way we PUTTING THE nal and innovative ideas are often lourful exciting evening that highli- › Fund to attract researchers FUNDS TO WORK however those that give rise to the ghts the importance of the research who are being recruited do medicine.” % greatest discoveries. They are also being done at the CRCHUM and Creation of a student scholarship frequently those that are not readily that is inspired by a theme that › Development of various 25 technology platforms fund to help them participate supported by the funding bodies. focuses upon research and science. in scientific symposiums % The CRCHUM thus devotes a part The evening provides an opportu- Dr. Lee Hartwell was awarded 50 of the monies it raises from its cha- nity to bring together several repre- PRESTIGIOUS GUESTS the 2001 Nobel Prize in Medicine Direct support to technology for his contribution to understan- % ritable activities to supporting less sentatives from Quebec’s business platforms and services provided conventional research programs, milieu and CRCHUM researchers, Quebec leaders have ding the life cycle of cells. The by the CRCHUM 25 in order to generate the conditions under the aegis of a Nobel Prize 11 sponsored the event research that led him to this pres- tigious award was never funded, that are suitable for making major winner Guest of Honour. Initiatives to help in the professional Nobel Prize in Medicine winners because it was considered to be discoveries. development of the Centre’s personnel 4 who have been Guests of Honour too speculative. 24 THE 2013-2014 2014 PROGRESS REPORT 25 THE 2013-2014 FINANCIAL PICTURE FINANCIAL PICTURE
For each dollar received from the Government of Quebec, the CRCHUM is able to generate five dollars from Canadian and international sources in the form FINANCIAL RESULTS, of federal grants, contracts, spon- sorships and private investments UNAUDITED from major companies. FOR THE FINANCIAL YEAR ENDED MARCH 31, 20141 $
REVENUES RESEARCH OPERATING CAPITAL ASSETS2 TOTAL Grants with peer committee $28 748 714 $3 895 58 $32 644 295 Non-recognized grants $8 410 273 $7 179 434 $15 589 707 Contracts with the private sector $11 619 953 $1 347 500 $12 967 45 Various funds $5 916 755 $5 916 755 $ $ Indirect costs of research $3 778 022 $3 778 022 Platforms $1 206 958 $1 206 958 Philanthropic activities and other $1 104 981 $1 104 981
TOTAL $54 695 696 $11 333 041 $7 179 434 $73 208 171
EXPENSES RESEARCH OPERATING CAPITAL ASSETS TOTAL Salaries and employee benefits $22 720 730 $5 180 487 $27 901 217 Services $3 021 938 $501 293 $3 523 231 Other supplies $28 953 027 $5 651 262 $34 604 288 $ $ $ Equipment $7 179 434 $7 179 434
TOTAL $54 695 695 $11 333 041 $7 179 434 $73 208 171
CAPITAL FUNDS $4 776 375
Note 1 : Unaudited financial information. Note 2 : Equipment purchases in the CHUM’s annual financial report (AS-471) are excluded from accessories research activities. 26 OUR COMMITTEES
DELEGATE FROM THE ASSEMBLY LEADER, IMAGING AND EXECUTIVE OF RESEARCHERS ENGINEERING RESEARCH THEME Manon Choinière Jacques de Guise This report is published COMMITTEE Researcher Researcher by the CRCHUM’s PRESIDENT OF THE COMMITTEE REPRESENTATIVE LEADER, GLOBAL HEALTH scientific division. Jacques Turgeon OF RESEARCH EMPLOYEES RESEARCH THEME Director Christian Demers Slim Haddad Photos Researcher Pierrette Gaudreau Co-ordinator of the institutional Productions Associate Scientific Director, animal protection committee LEADER, TISSUE INJURY, INFECTION, multimédias-CHUM Student Affairs IMMUNITY, AND INFLAMMATION Cosmos Image Pierrette Gaudreau RESEARCH THEME Brigitte Leclerc Associate Scientific Director, Marie-Josée Hébert Manager, Financial Management Student affairs Researcher June 2014 Brigitte M. Lespérance REPRESENTATIVE OF THE CRCHUM LEADER, EVALUATION, CARE SYSTEMS EXECUTIVE DIRECTOR CHUM RESARCH CENTER Interim Associate Director, Administration AND SERVICES RESEARCH THEME Yvan Gendron Janusz Kaczorowski (CRCHUM) Vincent Poitout Associate Executive Director Researcher Pavillion R Scientific Director 900 Saint Denis Street Brigitte M. Lespérance LEADER, CANCER RESEARCH THEME Paolo Renzi Interim Assistant Director, Anne-Marie Mes-Masson Montreal (Quebec) H2X 0A9 Interim Associate Scientific Director, Administration Researcher Clinical Research LEADER, NEUROSCIENCE THEME 514 890-8000 Brigitte Leclerc www.crchum.com Financial management Manager Alexandre Prat MANAGEMENT Researcher [email protected] COMMITTEE Josée Leclerc Assistant, Administration Paolo Renzi Interim Associate Scientific Director – CHAIRMAN ISBN 978-2-9813070-2-6 Les jeux de ficelles (Cat’s cradle) This large sculpture characteri- Jacques Turgeon DELEGATE FROM THE ASSEMBLY Clinical Research OF RESEARCHERS Legal deposit PIERRE BOURGAULT zed by organic shapes, that is both Director LEADER, RISKS TO HEALTH Bibliothèque et Archives Anne-Marie Mes-Masson Materials: Aluminium transparent and light, generates a RESEARCH THEME nationales du Québec, 2014 Researcher Sylvie Beaulieu Jack Siemiatycki Library and Archives with a fine-brushed finish kind of asymmetrical movement in Assistant to the Scientific Director Vincent Poitout Researcher Canada, 2014 Dimensions: 525 cm. high, a built environment. A graphic and REPRESENTATIVE OF THE Scientific Director LEADER, CARDIOMETABOLIC 365 cm. wide and 375 cm. in depth sculptural poem transposed into a VICE-RECTOR IN CHARGE RESEARCH THEME © CRCHUM, 2014 Types of construction: public space. This work is part of OF RESEARCH AT THE UNIVERSITÉ Marc Prentki Johanne Tremblay Reproduction of material rectangular tubing, four welded the artist’s Les sculptures habitables DE MONTRÉAL Researcher contained in this publication Researcher sides (20.5 cm. x 17 cm.) series, which he began in 1969. Dominique Bérubé is permitted, except for Associate Vice-Rector of Research, Paolo Renzi commercial purposes, with Creation and Innovation, Interim Associate Scientific Director – ADVISORY acknowledgment of its source. This work was chosen within the framework of the Government’s policy at the Université de Montréal Clinical Research COMMITTEE Partial reproduction must accurately represent the text used. geared towards integrating the arts into the architecture and built environ- REPRESENTATIVE OF THE Marie-Josée Samson ment of Government and public sites, which compels any organization that CHUM EXECUTIVE DIRECTOR Dr. Marc G. Caron Assistant, Clinical Research Duke University receive grants from the State to set aside at least 1% of their budget to Jocelyn Boucher create or purchase works of art. Associate Executive Director, Dr. Jean-Laurent Casanova administrative affairs at the CHUM SCIENTIFIC Rockefeller University REPRESENTATIVE OF THE DEAN COMMITTEE and Université Paris Descartes OF THE UNIVERSITÉ DE MONTRÉAL CHAIRMAN Dr. Pierre Corvol FACULTY OF MEDICINE Vincent Poitout Collège de France Daniel Bourbonnais Scientific Director Vice-Dean of Research and Scientific Dr. Marcel Goldberg Innovation at the Université Sylvie Beaulieu Université de Versailles de Montréal Faculty of Medicine Assistant to the Scientific Director Saint-Quentin-en-Yvelines Pavillion R 900 Saint Denis Street Montreal (Quebec) H2X 0A9
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