Journal of Investigative Genomics Research Article Open Access GST polymorphisms and GST enzyme activity in type 1 myotonic dystrophy Abstract Volume 2 Issue 2 - 2015 Glutathione S-transferases (GSTs) play an important role in protecting cells from damage Ashok Kumar,1 Sarita Agarwal,1 Suni,l caused by endogenous and exogenous compounds. In present study, we investigated the 2 association of GST gene polymorphisms (GSTT1, GSTM1, GSTP1 and GSTM3) and its Pradhan 1 enzyme activity in DM1 affected Indian population. Serum GST level was assessed by Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, India using GST-kit. GSTM1 (null or present) & GSTT1 (null or present) GSTM3 (AA, AB 2Department of Neurology, Sanjay Gandhi Post Graduate and BB) & GSTP1 (Ile/Ile, Ile/Val and Val/Val -105) polymorphism were analyzed. The Institute of Medical Sciences, India serum GST significantly reduced in the patient group compared to the control group and significantly correlated with diabetes. Patients had significantly higher (except GSTM3A/B) Correspondence: Sarita Agarwal, Department of Genetics, GSTM1*0 (GSTM1 null genotype), GSTT1*0 and GSTP1 (ile/val) frequency than Sanjay Gandhi Post Graduate Institute of Medical Sciences, controls. The deletion frequencies (GSTM1 and GSTT1) and GSTP1 (ile/val) were not Lucknow, India- 226014, Tel 91 522 249 4349, Fax 9152 2266 associated with higher risk while heterozygous frequency of GSTM3 (A/B) increased risk 8017, Email
[email protected] ratio up to three fold. The GSTM1, GSTT1, GSTM3 genotypes correlated with dyspepsia, age at presentation and duration of disease respectively. The allelic frequencies were 0.46, Received: January 12, 2015 | Published: March 04, 2015 0.54 and 0.48, 0.52 for GSTM3*A and GSTM3*B and were 0.61, 0.39 and 0.55, 0.45 for ile (A) and val (G) of GSTP1 for DM1 patients and control group respectively.