October 27, 2020 PROFESSOR STEPHEN HEDRICK, Professor
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Medical Leadership and Affiliate Providers
Scripps Proton Therapy Center Medical Leadership and Affiliate Providers SCRIPPS HEALTH AND SCRIPPS CLINIC – Scripps Health provides clinical management services for Scripps Proton Therapy Center and Scripps Clinic oversees the center’s medical services. Founded in 1924 by philanthropist Ellen Browning Scripps, Scripps Health is a nonprofit integrated health system based in San Diego, Calif. Scripps treats a half-million patients annually through the dedication of 2,600 affiliated physicians and 13,500 employees among its five acute-care hospital campuses, hospice and home health care services, and an ambulatory care network of physician offices and 26 outpatient centers and clinics. With more than 500 physicians and 50 medical and surgical specialties, Scripps Clinic provides care for a wide range of diseases and conditions at 13 locations across San Diego County. Recognized as a leader in the prevention, diagnosis, and treatment of disease, Scripps is also at the forefront of clinical research, genomic medicine, wireless health care and graduate medical education. With three highly respected graduate medical education programs, Scripps is a longstanding member of the Association of American Medical Colleges. Truven Health Analytics (formerly Thomson Reuters) has named Scripps one of the top five large health systems in the nation. Scripps is nationally recognized in six specialties by U.S. News & World Report, which places Scripps’ cardiovascular program among the top 20 in the country. Scripps has been consistently recognized by Fortune, Working Mother magazine and AARP as one of the best places in the nation to work. For more information, visit www.scripps.org. RADY CHILDREN’S HOSPITAL-SAN DIEGO – Rady Children’s Hospital-San Diego is an affiliate provider of pediatric care at Scripps Proton Therapy Center. -
Speaker Bios
Moores UCSD Cancer Center Industry/Academia Translational Oncology Symposium Speaker Bios David R. Bentley, D.Phil. Vice President & Chief Scientist, Illumina, Inc. David Bentley, Ph.D., is Chief Scientist for Illumina’s Sequencing business. His major research interest is the study of human sequence variation. He was previously Head of Human Genetics and founding member of the Board of Management at the Wellcome Trust Sanger Institute where he played leading roles in the Institute’s contribution to the human genome referencing sequence, the SNP Consortium and the International HapMap Project. Dr. Bentley earned a degree in Natural Sciences from the University of Cambridge, took a DPhil at the University of Oxford, and is currently a Fellow of the Academy of Medical Sciences. Clara D. Bloomfield, M.D. Distinguished University Professor William G. Pace III Professor of Cancer Research Cancer Scholar and Senior Advisor, Ohio State University Comprehensive Cancer Center and James Cancer Hospital and Solove Research Institute Education &Academic Appointments: 1968 M.D. U Chicago; 1973-80, Assistant, Associate Prof. of Medicine, U Minnesota (U. MN), Minneapolis, MN; 1980-89 Prof. of Medicine, Div. of Oncology, U.MN; 1989-97 Prof. of Medicine & Chief, Div. of Oncology, State University of NY at Buffalo; 1989-97 Chair, Department of Medicine, Roswell Park Cancer Institute (RPCI), Buffalo, NY; 1997-2001 Director, Div. of Hematology & Oncology, Department of Internal Medicine, The Ohio State University College of Medicine & Public Health (OSU COMPH), Columbus, OH; 1997- William G. Pace III Endowed Chair in Cancer Research & Prof, OSU; 1997-2003 Director, Comprehensive Cancer Center (CCC) & Deputy Director, James Cancer Hospital & Solove Research Institute (JCH), OSU; 2003- Cancer Scholar & Senior Advisor, OSUCCC & JCH; 2006- Distinguished University Prof. -
VASDHS Psychology Internship Brochure
2021-22 UCSD/VA PSYCHOLOGY INTERNSHIP TRAINING PROGRAM Department of Psychiatry University of California, San Diego VA San Diego Healthcare System Co-Directors Sandra Brown, Ph.D., ABPP Amy Jak, Ph.D. Applicant Manual Last updated September 2020 Dear Prospective Applicant, Thank you for your interest in the UCSD/VA Psychology Internship Training Program. In the following pages, you will find detailed information about our internship, including clinical training, didactic experiences, research opportunities, our faculty, and application instructions. Our program is based on the scientist-practitioner model. As such, we seek competitive applicants interested and experienced in both research and clinical practice, particularly those interested in academic careers. Clinical training and didactic experiences integrate cutting-edge evidence-based techniques with a foundation of established empirically-supported treatments and assessment. We also recognize the importance of diversity represented by our trainees and faculty, as well as in our patients. We encourage those of diverse backgrounds, in all the many ways that diversity is defined, to apply to our program. Our full-time internship has been accredited by APA since 1986 (Further information about accreditation of this program can be found at: Office of Program Consultation and Accreditation, American Psychological Association, 750 First Street, N.E., Washington, DC 20002-4242, Phone: (202) 336-5979, Fax: (202) 336-5978, Email: [email protected], Web: www.apa.org/ed/accreditation). For the 2021-2022 year, interns will earn an annual stipend of $29,212. Our competitive benefits, both for UCSD and for the VA, include health insurance, paid leave days, and paid holidays. The COVID-19 pandemic has led our faculty to implement multiple changes in our training program. -
Revised January 2003
Revised 9 June 2017 CURRICULUM VITAE NAME Anjana Rao OFFICE ADDRESS La Jolla Institute for Allergy & Immunology 9420 Athena Circle La Jolla, CA 92037 Telephone: (858) 952-7155/7161 FAX: (858) 752-6984 Email: [email protected] PLACE OF BIRTH Washington, D. C., USA EDUCATION 1970 B.Sc. Osmania University, Hyderabad, India 1972 M.Sc. Osmania University, Hyderabad, India (Physics) 1978 Ph.D. Harvard University, Cambridge, MA (Biophysics) POSTDOCTORAL TRAINING 1978-1979 Fellow in Medicine, Harvard Medical School 1979-1981 Fellow in Pathology, Harvard Medical School ACADEMIC APPOINTMENTS 1981-1984 Instructor in Pathology, Harvard Medical School 1984-1992 Assistant Professor of Pathology, Harvard Medical School 1993-1995 Associate Professor of Pathology, Harvard Medical School 1981-2009 Board of Tutors, Department of Biochemistry and Molecular Biology, Harvard University 1988-1995 Associate Head Tutor, Department of Biochemistry and Molecular Biology, Harvard University 1996-2010 Professor of Pathology, Harvard Medical School 1995-2011 Senior Investigator, Immune Disease Institute 2009-2011 Program in Cellular and Molecular Medicine, Children’s Hospital Boston 2010-present Professor, Division of Signaling and Gene Expression, La Jolla Institute (LJI) 2011-present Professor, Sanford Consortium for Regenerative Medicine, La Jolla 2011-present Affiliate faculty appointment, Department of Pharmacology, UCSD 2011-present Faculty member, Biomedical Sciences Graduate Program, UCSD 2011-present Health Sciences Immunity/Infection/Inflammation (Triple I), UCSD -
SDSC Welcomes Halicioğlu Data Science Institute Staff
SAN DIEGO SUPERCOMPUTER CENTER at UC SAN DIEGO Newsletter innovators JAN | FEB 2018 INSIDE INNOV8@SDSC 2 Welcome from SDSC Director Headlines 3 SDSCers Take the CENIC Route Staff Innovator 4 Meet Kevin Coakley Research 5 SDSC Simulations Advance Heart SDSC Welcomes Halicioğlu Data Drug Design Science Institute Staff Comet Shines in Novel LED Research UC San Diego’s official launch of the year’s announcement of a $75 million Halicioğlu Data Science Institute (HDSI) donation from UC San Diego Alumnus Education in early March was welcomed by SDSC, Taner Halicioğlu (hah-li-jyo-loo) to create 6 REHS Gearing up for Summer! which will house research labs and of- such an institute. SDSC Interns Present at fices for HDSI’s senior staff and faculty “It just made sense to have the institute Biomarkers Conference in the Center’s East Building. “We’re at SDSC because this place is all about pleased that SDSC will be home to many Partnerships data,” said Halicioğlu, who earned a HDSI faculty and staff as this exciting 7 UC San Diego, Japan’s AIST bachelor’s degree in computer science at new initiative gets underway,” said SDSC Expand Alliance the UC San Diego in 1996 and interned Director Michael Norman. “We look for- at SDSC in 1995 and 1996. In remarks San Diego County Funds ward to SDSC being a hub of connectivity during the event, he noted that “data sci- New HPWREN Upgrades for data analytics and innovation for the ence has technically always existed, but entire UC San Diego campus.” Industry Relations I don’t think it really started to coalesce 8 Growing an Innovation Platform UC San Diego Chancellor Pradeep K. -
University of California, San Diego Annual Financial Report 2009–10
UNIVERSITY OF CALIFORNIA, SAN DIEGO ANNUAL FINANCIAL REPORT 2009–10 UNIVERSITY OF CALIFORNIA, SAN DIEGO ANNUAL FINANCIAL REPORT 2009–10 1 Chancellor Fox Awarded the NATIONAL MEDAL OF SCIENCE UC SAN DIEGO CHANCELLOR MARYE ANNE FOX received the National Medal of Science in 2010, the highest honor bestowed by the United States government on scientists, engineers, and inventors. A nationally recognized organic chemist and academic leader, Fox has been elected to membership in the National Academy of Sciences and the American Philosophical Society, and to fellowships in the American Academy of Arts and Sciences and the American Association for the Advance- ment of Science. She has also received honorary degrees from twelve U.S. institutions. Her research has focused on fundamental principles that were later translated into practical use in solar energy conversion, environmental remediation, and materials science. Fox is the most recent member of the UC San Diego community to receive this prestigious award. Previous living National Medal of Science recipients from UC San Diego are E. Margaret Burbidge, astrophysics (1983); Walter Munk, geophysics (1983); Michael H. Freedman, mathematics (1987); Yuan-Cheng Fung, bioen- gineering (2000); Andrew Viterbi, electrical and computer engineering (2008); and Craig Venter, pharmacology (2009). Clockwise from top: Chancellor Marye Anne Fox; Fox receives the medal from President Barack Obama at the White House, November 17, 2010; an inspirational note Fox wrote as a young girl “I always thought I would be a scientist. Once you’ve understood something that didn’t exist before, it’s almost like you have to figure out what the answer to the next question is, and generate the next question after that. -
Printable UCSD
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Radiation Medicine and Applied Technologies
University of California San Diego Department of Radiation Medicine and Applied Sciences: Department Overview 2 University of California San Diego University of California System The University of California (UC) http://www.universityofcalifornia.edu was chartered in 1868. As a whole, the UC is one of the largest Universities in the world consisting of over 7,000 faculty members, 160,000 students and employs approximately 121,000 faculty, staff and academics statewide. The UC system is currently comprised of 10 separate campuses: Berkeley, Davis, Irvine, Los Angeles, Merced, Riverside, San Diego, San Francisco, Santa Barbara and Santa Cruz. In 2011, there were over 76,000 student applications. UC is affiliated with the Lawrence Livermore and Lawrence Berkeley Laboratories and the Los Alamos Facility. Each campus boasts a unique environment, and a variety of achievements, honors and academic disciplines. There are 5 medical centers in the UC system: Davis, Irvine, Los Angeles, San Diego and San Francisco. A medical center in Riverside is under development. The 5 UC Medical Centers support the clinical teaching programs of the medical and health sciences schools and receive more than 138,000 inpatient discharges, 261,000 emergency room visits and more than 3.6 million outpatient visits per year. Collectively, these centers comprise the largest health care system in California. University of California San Diego (UCSD) UC San Diego http://www.ucsd.edu/ occupies 1200 acres along the Pacific coast in La Jolla, California. One of the premiere campuses of the UC system, UC San Diego is also one of the youngest (founded in 1960). The first graduate student was admitted in 1960 and the first undergraduate in 1964. -
NR4A Transcription Factors Limit CAR T Cell Function in Solid Tumors
LETTER https://doi.org/10.1038/s41586-019-0985-x NR4A transcription factors limit CAR T cell function in solid tumours Joyce Chen1,2,3,4*, Isaac F. López-Moyado1,4,5, Hyungseok Seo1, Chan-Wang J. Lio1, Laura J. Hempleman1, Takashi Sekiya6, Akihiko Yoshimura7, James P. Scott-Browne1,4,9,10* & Anjana Rao1,3,4,8,10* T cells expressing chimeric antigen receptors (CAR T cells) targeting CD8+CD45.1+ OT-I cells (specific for chicken ovalbumin (OVA) human CD19 (hCD19) have shown clinical efficacy against B cell SIINFEKL peptide presented by H-2Kb; Extended Data Fig. 2a, b) malignancies1,2. CAR T cells have been less effective against solid showed similar tumour growth rates (Extended Data Fig. 2c); low tumours3–5, in part because they enter a hyporesponsive (‘exhausted’ numbers of CAR T cells were transferred to minimize tumour rejec- or ‘dysfunctional’) state6–9 triggered by chronic antigen stimulation tion (Extended Data Fig. 2d). Eight days after adoptive transfer, CAR and characterized by upregulation of inhibitory receptors and loss of and OT-I tumour-infiltrating lymphocytes (TILs) (Fig. 1b, Extended effector function. To investigate the function of CAR T cells in solid Data Fig. 2b, e, f) comprised around 18% and 9%, respectively, of CD8+ tumours, we transferred hCD19-reactive CAR T cells into hCD19+ TILs (Fig. 1c) and exhibited similar proportions of PD-1hiTIM3hi cells tumour-bearing mice. CD8+CAR+ tumour-infiltrating lymphocytes compared to endogenous TILs (Fig. 1b, Extended Data Fig. 2b). All and CD8+ endogenous tumour-infiltrating lymphocytes expressing TILs produced low levels of TNF and IFNγ upon re-stimulation with the inhibitory receptors PD-1 and TIM3 exhibited similar profiles PMA and ionomycin (Fig. -
5 24 21 Summary Corona Virus Update by H. Robert Silverstein, MD, FACC for the Preventive Medicine Center
5 24 21 Summary Corona Virus Update by H. Robert Silverstein, MD, FACC for the Preventive Medicine Center Clyde W. Yancy, MD, Vice Dean for Diversity and Inclusion Chief of Cardiology in the Department of Medicine, Feinberg School of Medicine at Northwestern University in Chicago Clyde W. Yancy, MD: “I’m exhausted by the stress; disheartened by the toll on human life; concerned deeply about the exposure to healthcare workers- BUT, I am emboldened by the display of courage, selflessness, compassion, and sacrifice that I see in physicians, nurses and health care workers across the country.” “It is not a case of ‘don’t confuse me with the facts’, but the best clinical insights exceed so called knowledge by at least one step.” History, precedents, similarities, virus structure and invasion, pathology, physiology, lethality vs safety in perspective, China, geography, EU vs USA comparison, time-line, media, politics, pandemic modelling, symptoms, lockdown, economics, joblessness, vascular-platelet-glycocalyx clotting, testing, ventilators, medications, vaccines, supplements, diet: This 2019 corona virus CoV2-19 is an entirely new RNA virus with 30 proteins. Corona viruses have the largest known viral genome. The RNA of a corona virus is single-stranded. The word 1 “VIRUS” means “poison.” A human cell has 20,000 different proteins. Being an RNA virus, it is similar to hepatitis C; it is not a DNA virus like hepatitis B. There are 200 viruses that can cause the common cold and several of these are corona viruses. “Corona” is Latin for “crown” which is how the virus looks in the microscope as if it has an encircling crown. -
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M A Y 2 0 0 1 Can you believe his eyes or his nose or his smile? Facing the Truth Using Science to Evaluate Expressions Hypertension • DNA’s Machinery • Classroom Design • Molecular Art 18 Touching the Invisible One Molecule at a Time Carlos Bustamante, who took apart toy cars as a boy, is now exploring the machinery of DNA. Cover: Courtesy of Paul Ekman M AY 2 0 0 1 FEATURES VOLUME 14 NUMBER 2 12 Facing the Truth 22 Solving 28 Overcoming the A New Tool to Analyze Hypertension’s Intractable Our Expressions Deadly Puzzle Problem Rick Lifton’s Team at Increasing the Numbers of Yale Is Putting the Pieces Underrepresented Minorities Together in Science 34 N OTA B ENE 2 Awards and Honors 39 Teens Tend to Be Night Owls HHMI TRUSTEES ETTERFROM James A. Baker, III, Esq. L HHMI Awards $15 Million to Senior Partner THE P RESIDENT Baker & Botts European Researchers Alexander G. Bearn, M.D. Executive Officer American Philosophical Society 3 The Other Genome Race Adjunct Professor 40 Untangling the Web of Yeast The Rockefeller University Professor Emeritus of Medicine Protein Interactions Cornell University Medical College Frank William Gay Former President and Chief Executive Officer U P F RONT SUMMA Corporation 41 Vaccination Experiment Casts James H. Gilliam, Jr., Esq. Former Executive Vice President 4 The Human Genome Goes to a Key Guilty Vote Against and General Counsel, Beneficial Corporation Hanna H. Gray, Ph.D., Chairman Amyloid in Alzheimer’s President Emeritus and High School Harry Pratt Judson Distinguished Service Professor of History The University of Chicago 6 Fruit Fly Gene Survey Finds Garnett L. -
Tet2 and Tet3 Cooperate with B-Lineage Transcription Factors To
RESEARCH ARTICLE Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility Chan-Wang Lio1†, Jiayuan Zhang2†, Edahı´Gonza´ lez-Avalos1, Patrick G Hogan1, Xing Chang1,2,3*, Anjana Rao1,3,4,5* 1Division of Signaling and Gene Expression, San Diego, United States; 2Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China; 3Sanford Consortium for Regenerative Medicine, San Diego, United States; 4Department of Pharmacology, University of California, San Diego, San Diego, United States; 5Moores Cancer Center, University of California, San Diego, San Diego, United States Abstract Ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine, facilitating DNA demethylation and generating new epigenetic marks. Here we show that concomitant loss of Tet2 and Tet3 in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 expression and impaired the germline transcription and rearrangement of the Igk locus. Tet2/3-deficient pro-B cells showed increased CpG methylation at the Igk 3’ and distal enhancers that was mimicked by depletion of E2A or PU.1, as well as a global decrease in chromatin accessibility at enhancers. Importantly, re-expression of the Tet2 catalytic domain in *For correspondence: Tet2/3-deficient B cells resulted in demethylation of the Igk enhancers and restored their chromatin [email protected] (XC); arao@ accessibility. Our data suggest that TET proteins and lineage-specific transcription factors lji.org (AR) cooperate to influence chromatin accessibility and Igk enhancer function by modulating the modification status of DNA.