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Special Edition Inside
A Publication by The American Society for the Pharmacology and Experimental Therapeutics Pharmacologist Inside: Feature articles from 2014-2015 Special Edition VISIT THE ASPET CAREER CENTER TODAY! WWW.ASPET.ORG/CAREERCENTER/ 4 5 12 21 30 41 WHAT YOU NEED: ASPET’S CAREER CENTER HAS IT 52 Jobseekers: Employers: No registration fee Searchable résumé database Advanced search options Hassle-free posting; online account management tools 61 Sign up for automatic email notifi cations of new jobs that Reach ASPET’s Twitter followers (over 1,000), match your criteria LinkedIn Members (over 2,000), and email subscribers (over 4,000) Free & confi dential résumé posting 71 Post to just ASPET or to entire NHCN network Access to jobs posted on the National Healthcare Career Network (NHCN) Sign up for automatic email notifications of new résumés that match your criteria Career management resources including career tips, coaching, résumé writing, online profi le development, Job activity tracking and much more ASPET is committed to your success: The ASPET Career Center is the best resource for matching job seekers and employers in the pharmacology and related health science fi elds. Our vast range of resources and tools will help you look for jobs, fi nd great employees, and proactively manage 9650 Rockville Pike, Bethesda, MD 20814-3995 your career goals. Main Office: 301.634.7060 www.aspet.org ASPET Career Center Full Page Ad 2015 Updated.indd 1 1/15/2016 3:18:16 PM The Pharmacologist is published and distributed by the American Society for Pharmacology and Experimental Therapeutics. THE PHARMACOLOGIST VISIT THE ASPET CAREER CENTER TODAY! PRODUCTION TEAM Rich Dodenhoff Catherine Fry, PhD WWW.ASPET.ORG/CAREERCENTER/ Judith A. -
Medical Leadership and Affiliate Providers
Scripps Proton Therapy Center Medical Leadership and Affiliate Providers SCRIPPS HEALTH AND SCRIPPS CLINIC – Scripps Health provides clinical management services for Scripps Proton Therapy Center and Scripps Clinic oversees the center’s medical services. Founded in 1924 by philanthropist Ellen Browning Scripps, Scripps Health is a nonprofit integrated health system based in San Diego, Calif. Scripps treats a half-million patients annually through the dedication of 2,600 affiliated physicians and 13,500 employees among its five acute-care hospital campuses, hospice and home health care services, and an ambulatory care network of physician offices and 26 outpatient centers and clinics. With more than 500 physicians and 50 medical and surgical specialties, Scripps Clinic provides care for a wide range of diseases and conditions at 13 locations across San Diego County. Recognized as a leader in the prevention, diagnosis, and treatment of disease, Scripps is also at the forefront of clinical research, genomic medicine, wireless health care and graduate medical education. With three highly respected graduate medical education programs, Scripps is a longstanding member of the Association of American Medical Colleges. Truven Health Analytics (formerly Thomson Reuters) has named Scripps one of the top five large health systems in the nation. Scripps is nationally recognized in six specialties by U.S. News & World Report, which places Scripps’ cardiovascular program among the top 20 in the country. Scripps has been consistently recognized by Fortune, Working Mother magazine and AARP as one of the best places in the nation to work. For more information, visit www.scripps.org. RADY CHILDREN’S HOSPITAL-SAN DIEGO – Rady Children’s Hospital-San Diego is an affiliate provider of pediatric care at Scripps Proton Therapy Center. -
VASDHS Psychology Internship Brochure
2021-22 UCSD/VA PSYCHOLOGY INTERNSHIP TRAINING PROGRAM Department of Psychiatry University of California, San Diego VA San Diego Healthcare System Co-Directors Sandra Brown, Ph.D., ABPP Amy Jak, Ph.D. Applicant Manual Last updated September 2020 Dear Prospective Applicant, Thank you for your interest in the UCSD/VA Psychology Internship Training Program. In the following pages, you will find detailed information about our internship, including clinical training, didactic experiences, research opportunities, our faculty, and application instructions. Our program is based on the scientist-practitioner model. As such, we seek competitive applicants interested and experienced in both research and clinical practice, particularly those interested in academic careers. Clinical training and didactic experiences integrate cutting-edge evidence-based techniques with a foundation of established empirically-supported treatments and assessment. We also recognize the importance of diversity represented by our trainees and faculty, as well as in our patients. We encourage those of diverse backgrounds, in all the many ways that diversity is defined, to apply to our program. Our full-time internship has been accredited by APA since 1986 (Further information about accreditation of this program can be found at: Office of Program Consultation and Accreditation, American Psychological Association, 750 First Street, N.E., Washington, DC 20002-4242, Phone: (202) 336-5979, Fax: (202) 336-5978, Email: [email protected], Web: www.apa.org/ed/accreditation). For the 2021-2022 year, interns will earn an annual stipend of $29,212. Our competitive benefits, both for UCSD and for the VA, include health insurance, paid leave days, and paid holidays. The COVID-19 pandemic has led our faculty to implement multiple changes in our training program. -
Appendix 1*) for Essential Information Very Well Illustrated in Google and Wikipedia
Appendix 1*) For Essential Information Very Well Illustrated in Google and Wikipedia *) in Support of the Text with Literature Citations. Referrals to illustrations in Appendix 2. Cancer in the Plant. The insertion of the Agrobacterium tumefaciens circular plasmid T (transferred) DNA into the genome of its new host, the plant (Gelvin BS. Microbiol Molecular Biol Rev 2003;67:16–37). The plant cancer “crown gall” (agrocallus; Agrobacterial crown gall) consists of malignantly transformed cells replicating the agrobacterial T DNA plasmid (reviewed in postscript Table XXXV). For reference: Koncz C Mayerhofer R Koncz-Kálmán Zs et al EMBO J 1990;9:1337–1346. Transfer of potentially oncogenic bacterial genes and proteins to patients: Septicemic Bacteroides enterotoxigenic (Sinkovics J G & Smith JP Cancer 1970;25:663–671; Viljoen KS et al PLoS One 2015;10(3):e0119462); Bartonella bacilliformis etc (Guy L et al PLoS Genet 2013;9(3):e1003393; Harms A & Dehio C Clin Microbiol Rev 2012;25:42–78; Llosa M et al Trends Microbiol 2012;20:355–9; Minnick MF et al PLoS Negl Trop Dis 2014;6(7):e2919); Helicobacter pylori (Bonsor DA et al J Biol Chem 2015;pii:jbc.M115.641829; Su YL et al J Immunol 2015;194:3997–4007; Vaziri F et al Pathog Dis 2015;73(3). pii.ftu021); Porphyromonas gingivalis (Katz J et al Int J Oral Sci 2011;3:209–215); Tuberculous infections with A. tumefaciens in patients (Ramirez FC et al Clin Infect Dis 1992;15:938–940). DNA-binding Antibodies. DNA- (or RNA-) binding proteins use zink finger motifs, leucine zippers and winged (beta-sheet loops) helix-turn helix motifs (HTH, two helices separated by the loop, RNA/DNA-binding domains) in recognition of RNA/DNA receptors for attachment. -
SDSC Welcomes Halicioğlu Data Science Institute Staff
SAN DIEGO SUPERCOMPUTER CENTER at UC SAN DIEGO Newsletter innovators JAN | FEB 2018 INSIDE INNOV8@SDSC 2 Welcome from SDSC Director Headlines 3 SDSCers Take the CENIC Route Staff Innovator 4 Meet Kevin Coakley Research 5 SDSC Simulations Advance Heart SDSC Welcomes Halicioğlu Data Drug Design Science Institute Staff Comet Shines in Novel LED Research UC San Diego’s official launch of the year’s announcement of a $75 million Halicioğlu Data Science Institute (HDSI) donation from UC San Diego Alumnus Education in early March was welcomed by SDSC, Taner Halicioğlu (hah-li-jyo-loo) to create 6 REHS Gearing up for Summer! which will house research labs and of- such an institute. SDSC Interns Present at fices for HDSI’s senior staff and faculty “It just made sense to have the institute Biomarkers Conference in the Center’s East Building. “We’re at SDSC because this place is all about pleased that SDSC will be home to many Partnerships data,” said Halicioğlu, who earned a HDSI faculty and staff as this exciting 7 UC San Diego, Japan’s AIST bachelor’s degree in computer science at new initiative gets underway,” said SDSC Expand Alliance the UC San Diego in 1996 and interned Director Michael Norman. “We look for- at SDSC in 1995 and 1996. In remarks San Diego County Funds ward to SDSC being a hub of connectivity during the event, he noted that “data sci- New HPWREN Upgrades for data analytics and innovation for the ence has technically always existed, but entire UC San Diego campus.” Industry Relations I don’t think it really started to coalesce 8 Growing an Innovation Platform UC San Diego Chancellor Pradeep K. -
University of California, San Diego Annual Financial Report 2009–10
UNIVERSITY OF CALIFORNIA, SAN DIEGO ANNUAL FINANCIAL REPORT 2009–10 UNIVERSITY OF CALIFORNIA, SAN DIEGO ANNUAL FINANCIAL REPORT 2009–10 1 Chancellor Fox Awarded the NATIONAL MEDAL OF SCIENCE UC SAN DIEGO CHANCELLOR MARYE ANNE FOX received the National Medal of Science in 2010, the highest honor bestowed by the United States government on scientists, engineers, and inventors. A nationally recognized organic chemist and academic leader, Fox has been elected to membership in the National Academy of Sciences and the American Philosophical Society, and to fellowships in the American Academy of Arts and Sciences and the American Association for the Advance- ment of Science. She has also received honorary degrees from twelve U.S. institutions. Her research has focused on fundamental principles that were later translated into practical use in solar energy conversion, environmental remediation, and materials science. Fox is the most recent member of the UC San Diego community to receive this prestigious award. Previous living National Medal of Science recipients from UC San Diego are E. Margaret Burbidge, astrophysics (1983); Walter Munk, geophysics (1983); Michael H. Freedman, mathematics (1987); Yuan-Cheng Fung, bioen- gineering (2000); Andrew Viterbi, electrical and computer engineering (2008); and Craig Venter, pharmacology (2009). Clockwise from top: Chancellor Marye Anne Fox; Fox receives the medal from President Barack Obama at the White House, November 17, 2010; an inspirational note Fox wrote as a young girl “I always thought I would be a scientist. Once you’ve understood something that didn’t exist before, it’s almost like you have to figure out what the answer to the next question is, and generate the next question after that. -
Emil Frei III, MD: in Memoriam (1924–2013)
Cancer Obituary Research Emil Frei III, MD: In Memoriam (1924–2013) "Tackle a big problem and stay with it"—advice from Emil Frei II to Emil Frei III Emil Frei III (Tom) was probably the most admired Amer- pleura-pneumonia–like organism. They worked out the nature ican cancer researcher of his generation. His death marks the of the infection in the ear canal of the rat and how to cure it with end of an amazing journey in oncology, a field that was in its a new antibiotic, tetracycline. Tom credited this and subsequent infancy in February 1955 when he arrived at the National experience with Dr. Zubrod (after both had moved to NCI) with Cancer Institute (NCI; Bethesda, MD). During his long career, teaching him about rigorous measurement in clinical research he contributed importantly to the cure of childhood leukemia, and the importance of the laboratory in bringing science to the Hodgkin's disease and other lymphomas, breast cancer, and bedside. other malignancies. It would be appropriate to state that his When Tom arrived at the NCI in 1955 at the age of 31 years, he work and that of his colleagues' has saved and will save millions decided to focus on the treatment of leukemia. Quantitative of lives throughout the world. Born in St. Louis, Tom Frei grew studies on leukemia were lacking; the relative response rates up in a deeply religious family, surrounded by artists and to two known chemotherapeutic agents, methotrexate and musicians. The family business was the Emil Frei Art Glass 6-mercaptopurine, were unknown; and no one had defined Company, founded by his grandfather and managed by his partial and complete responses. -
Printable UCSD
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October 2, 2020 | 8:30 A.M.—5:30 P.M
in Tumor Immunology and Cancer Immunotherapy Conference October 2, 2020 | 8:30 a.m.—5:30 p.m. Time Title Speaker Neli Ulrich, PhD 8:30 a.m. Welcome Executive Director, Comprehensive Cancer Center Huntsman Cancer Institute Antitumor Immune Responses Induced by PD-1 Antoni Ribas, MD, PhD 8:45 a.m. Blockade Therapy University of California Los Angeles Rational Tumor and Immune Cell Treatment Daniel Peeper, PhD 9:30 a.m. Combinations: A Functional Genomics Approach Netherlands Cancer Institute 10:15 a.m. Break Sandra D’Angelo, MD 10:30 a.m. Cancer Testis Antigens as Therapeutic Targets in Sarcoma Memorial Sloan Kettering Cancer Center New T Cell Receptors and Targets by Dissection of Andrew Sewell, PhD 11:15 a.m. Successful Cancer Immunotherapy Cardiff University Noon Lunch CAR T Cell-Based Combination Immunotherapy for Prasad S. Adusumilli, MD, FACS 1 p.m. Solid Tumors Memorial Sloan Kettering Cancer Center Overcoming Resistance to Immune Checkpoint Blockers Zihai Li, MD, PhD 1:45 p.m. by Targeting GARP-TGF-Beta Pathway The Ohio State University 2:30 p.m. Break From the Clinic to the Lab: Investigating Mechanisms of Padmanee Sharma, MD, PhD 2:45 p.m. Response and Resistance to Immune Checkpoint Therapy MD Anderson Cancer Center The Role of Gut and Tumor Microbiome in Response Jennifer Wargo, MD, MMSc 3:30 p.m. to Cancer Therapy MD Anderson Cancer Center 4:15 p.m. Break Ira Mellman, PhD 4:30 p.m. Mechanistic Basis of Cancer Immunotherapy Genetech Alana Welm, PhD 5:15 p.m. Closing Remarks Co-Director, Cell Response and Regulation Program Huntsman Cancer Institute SPEAKERS Prasad S. -
Radiation Medicine and Applied Technologies
University of California San Diego Department of Radiation Medicine and Applied Sciences: Department Overview 2 University of California San Diego University of California System The University of California (UC) http://www.universityofcalifornia.edu was chartered in 1868. As a whole, the UC is one of the largest Universities in the world consisting of over 7,000 faculty members, 160,000 students and employs approximately 121,000 faculty, staff and academics statewide. The UC system is currently comprised of 10 separate campuses: Berkeley, Davis, Irvine, Los Angeles, Merced, Riverside, San Diego, San Francisco, Santa Barbara and Santa Cruz. In 2011, there were over 76,000 student applications. UC is affiliated with the Lawrence Livermore and Lawrence Berkeley Laboratories and the Los Alamos Facility. Each campus boasts a unique environment, and a variety of achievements, honors and academic disciplines. There are 5 medical centers in the UC system: Davis, Irvine, Los Angeles, San Diego and San Francisco. A medical center in Riverside is under development. The 5 UC Medical Centers support the clinical teaching programs of the medical and health sciences schools and receive more than 138,000 inpatient discharges, 261,000 emergency room visits and more than 3.6 million outpatient visits per year. Collectively, these centers comprise the largest health care system in California. University of California San Diego (UCSD) UC San Diego http://www.ucsd.edu/ occupies 1200 acres along the Pacific coast in La Jolla, California. One of the premiere campuses of the UC system, UC San Diego is also one of the youngest (founded in 1960). The first graduate student was admitted in 1960 and the first undergraduate in 1964. -
UC SAN DIEGO: Celebrating Five DECADES Visionaries, Innovators, and Overachievers
Visionaries, InnovAtOrS, and OvErachievErS UC SAN DIEGO: CElEbrAting FIvE Decades rOGEr has A DrEAm, AND A NEw UC CAmpUS IS bOrN ... The vision and energies of Roger Revelle, director of Scripps Institution of Oceanography from 1951 to 1964, led to the establishment of UC San Diego. The university first received about 1,000 acres for the campus, much of it deeded as a gift from the city of San Diego, and another 545 acres of former San Diego pueblo land from the Marine Corps. 1903 Scripps Institution of Oceanography is established. 1960 1960 1962 1964 1966 1967 1968 1968 1968 1968 In September, the first In November, documents President John F. The first undergraduates UC San Diego begins The University of Califor- The first four-year The first students enroll UC San Diego Medical Scripps Institution of graduate students are signed to officially Kennedy signs a bill enroll at UC San Diego. operating University nia acquires 130 acres in undergraduate class in the UC San Diego Center surgeons Oceanography estab- enroll in science establish the University that commits the Hospital as its primary the La Jolla Farms area, receives degrees. School of Medicine. perform the region’s lishes the Deep Sea and engineering. of California, San Diego. federal government to clinical teaching facility. the first land purchased first kidney transplant. Drilling Program, transfer 436 acres of for UC San Diego. which explores the Camp Matthews to the earth’s crust. University of California. 1960 1970 1972 1972 1973 1976 1978 1978 1978 The landmark Central The UC San Diego Foun- The UCSD Alumni The UC San Diego The UC San Diego Scripps Institution of The UC San Diego Can- San Diego’s first bio- Library opens. -
AACR Settles Dispute with Toronto Hotels Over 2003 Annual Meeting
Vol. 31 No. 15 April 15, 2005 © Copyright 2005 The Cancer Letter Inc. All rights reserved. Price $335 Per Year AACR Settles Dispute With Toronto Hotels Over 2003 Annual Meeting Cancellation By Kirsten Boyd Goldberg The American Association for Cancer Research has settled a legal dispute with the Toronto Convention Center and hotels, stemming from the AACR 2003 Aftermath: cancellation of its annual meeting in April 2003. NCI Provided $2 Million The convention center and 19 hotels sought $6.2 million Canadian To Pay Washington from AACR as payment under contracts for housing the estimated 16,000 Convention Center, scientists and others who were expected to attend the meeting. Other Expenses Two days before the event was scheduled to begin, AACR cancelled . Page 2 it, citing the outbreak of Severe Acute Respiratory Syndrome in Toronto. (Continued to page 2) Washington Roundup: In Brief: Senate Committee AACR To Honor Eight Scientists Delays Session At Annual Meeting In Anaheim On FDA Nominee The American Association for Cancer Research will honor several . Page 4 scientists at its annual meeting April 16-20, in Anaheim, Calif. David Livingston, deputy director, Dana-Farber/Harvard Cancer Center National Academies: and the Emil Frei Professor of Genetics and Medicine, Harvard Medical Report Defines School, will receive the AACR-G.H.A. Clowes Memorial Award for his Indicators Of Progress contributions to the understanding of the molecular basis of cancer. In Quality of Care Charles Sawyers, investigator, Howard Hughes Medical Institute and . Page 5 Peter Bing Professor of Medicine, University of California, Los Angeles, will be awarded the AACR-Richard and Hinda Rosenthal Foundation Award Oversight Needed for his research in molecularly-targeted therapy, with special emphasis on For Cord Blood Banks, signaling pathway abnormalities in cancer cells as targets for drug therapy.