Joseph L. Mayberry, Sr. Lecture Department of Pathology

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The Twenty-Fourth Annual Joseph L. Mayberry, Sr. Lecture Department of Pathology This lecture honors Joseph L. Mayberry, Sr. for his interest in the relationship between chemicals and diseases. Northwestern University Feinberg School of Medicine Titia de Lange joined Rockefeller University in 1990 and has been the Leon Hess Professor since 1999. She is also the Director of the Anderson Center for Cancer Research and head of the laboratory for Cell Biology and Genetics at Rockefeller University, as well as an American Cancer Society Research Professor. Dr. de Lange received her Ph.D. in Biochemistry from the University of Amsterdam and The Netherlands Cancer Institute, and completed a post-doctoral fellowship with Harold E. Varmus, who received the Nobel Prize for the discovery of the cellular origin of retroviral oncogenes. Early in her career, she became one of the first scientists to isolate the telomeres of human chromosomes. Since then, she has identified a protein complex at telomeres, which she named shelterin. Her laboratory studies how the telomeric shelterin complex prevents the activation of DNA damage signaling pathways and blocks various forms of double-strand break (DSB) repair at chromosome ends as well as the role of telomeres in genome instability in cancer. Dr. de Lange is an elected member of the Dutch Royal Academy of Sciences, the European Molecular Biology Organization, the US National Academy of Sciences, the Institute of Medicine, and the American Academy for Arts and Sciences. Among her awards are the inaugural Paul Marks Prize for Cancer Research from Memorial Sloan Kettering Cancer Center, the 2011 Vilcek Prize for Biomedical Science, and the Heineken Prize from the Royal Dutch Academy for Arts and Sciences. In 2013, she was one of the 11 inaugural recipients of the Breakthrough Prize in Life Sciences; she also received the 2014 Canada Gairdner International Award. “Telomeres and cancer: tumor suppression and genome instability” Titia de Lange, PhD Tuesday, May 18, 2021 3:30 pm – 4:30 pm Northwestern University Feinberg School of Medicine Mayberry Lecture Series Inaugural Lecture June 17, 1997 Bruce Ames Second Lecture May 21, 1998 H. Robert Horvitz Third Lecture May 24, 1999 Peter Nowell Fourth Lecture June 13, 2000 Robert Roeder Fifth Lecture May 3, 2001 Bert O’Malley Sixth Lecture April 30, 2002 Marc Kirschner Seventh Lecture April 28, 2003 Mina Bissell Eighth Lecture June 8, 2004 Bruce Spiegelman Ninth Lecture May 17, 2005 Patricia Spear Tenth Lecture May 10, 2006 Elaine Fuchs Eleventh Lecture April 17, 2007 Robert Goldman Twelfth Lecture March 25, 2008 Tom Rapoport Thirteenth Lecture May 19, 2009 Michael Gimbrone Fourteenth Lecture June 8, 2010 Douglas Lowy Fifteenth Lecture May 12, 2011 Ronald Germain Sixteenth Lecture Nov. 13, 2012 Vann Bennett Seventeenth Lecture April 23, 2013 Anthony Pawson* Eighteenth Lecture April 15, 2014 Jennifer Lippincott-Schwartz Nineteenth Lecture May 12, 2015 Alan Hall* Twentieth Lecture April 12, 2016 Jean-Laurent Casanova Twenty-first Lecture April 11, 2017 Tom Misteli Twenty-second Lecture April 10, 2018 Peter Walter Twenty-third Lecture June 4, 2019 Ira Mellman Department of Pathology 303 E. Chicago Avenue Chicago, Illinois 60611 312.503.8144 feinberg.northwestern.edu/pathology *Canceled lectures .

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