pharmaceutics Review Drug-Rich Phases Induced by Amorphous Solid Dispersion: Arbitrary or Intentional Goal in Oral Drug Delivery? Kaijie Qian 1 , Lorenzo Stella 2,3 , David S. Jones 1, Gavin P. Andrews 1,4, Huachuan Du 5,6,* and Yiwei Tian 1,* 1 Pharmaceutical Engineering Group, School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK;
[email protected] (K.Q.);
[email protected] (D.S.J.);
[email protected] (G.P.A.) 2 Atomistic Simulation Centre, School of Mathematics and Physics, Queen’s University Belfast, 7–9 College Park E, Belfast BT7 1PS, UK;
[email protected] 3 David Keir Building, School of Chemistry and Chemical Engineering, Queen’s University Belfast, Stranmillis Road, Belfast BT9 5AG, UK 4 School of Pharmacy, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang 110122, China 5 Laboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland 6 Simpson Querrey Institute, Northwestern University, 303 East Superior Street, 11th Floor, Chicago, IL 60611, USA * Correspondence:
[email protected] (H.D.);
[email protected] (Y.T.); Tel.: +41-446339049 (H.D.); +44-2890972689 (Y.T.) Abstract: Among many methods to mitigate the solubility limitations of drug compounds, amor- Citation: Qian, K.; Stella, L.; Jones, phous solid dispersion (ASD) is considered to be one of the most promising strategies to enhance D.S.; Andrews, G.P.; Du, H.; Tian, Y. the dissolution and bioavailability of poorly water-soluble drugs.