MEDIA KIT 2018

New YORK CITY October 25, 2018 / 4 PRIX GALIEN USA FOUNDING COMMITTEE

/ 5 2018 AWARDS COMMITTEE

/ 6-7 GALIEN FORUM Overview & Background “They participated in the Forum”

/ 8-9 TESTIMONIALS FROM AROUND THE GLOBE

/ 10 HALL OF FAME - HISTORY OF THE PRIZE AND MEDAL

/ 11 PRIX GALIEN USA

/ 12 THE PRO BONO HUMANUM AWARD

/ 13 WHO WAS GALEN

/ 14 PRIX GALIEN MEDSTART UP

/ 15 PRIX GALIEN USA WINNERS

Pre-event & On-site Resources for Journalists For more information and Galien Foundation events are conducted fully on the record, and we welcome register for a press pass and invite members of the media to participate as engaged stakeholders via please contact: onsite discussion, as well as via social media, and to report on proceedings and outcomes. Finn Partners Holmes Report & PR News We certainly appreciate coverage of our events, but our priority is to help you Midsize Agency of the Year explore and uncover today’s key issues and connect with the people and diverse organizations we bring together that make the world a healthier place. Contact: Giana Gregga To help facilitate your engagement with our speakers and stakeholders, T +1 312 329 3910 we are delighted to work with you in the lead-up to our 2018 Forum and M +1 708 703 2210 Ceremony on: [email protected]

Arranging interviews with key speakers Helpful links and stakeholders www.galienfoundation.org Prix Galien USA Reserving private spaces for on-site interviews Forum (latest programs, participants, Sharing our latest programs and speaker lists registration, and reports) Pro Bono Humanum Award Providing hi-resolutions imagery (including photos Med StartUp Award of people, spaces, logos, etc.) Prix Galien Around the Globe Prix Galien Hall of Fame

2 innovation to improve the human condition

Mission

Sue Desmond-Hellmann, Ethiopia Clinic site visit

The Prix Galien Award recognizes outstanding achievements in improving the global human condition through the and politics. The outcome we seek is guided by the development of innovative drugs and synthesis principle that underpins the conduct of other treatments. science itself: successful innovation where financing, physical assets, knowledge and skills are combined from many sources to move new ideas quickly “from The Prix Galien was created in 1970 in the bench to the bedside,” on behalf of patients everywhere. honor of Galen, the father of medical science and modern pharmacology. A truly global program present in 14 countries* Our program includes a review of contributions from Worldwide the Prix Galien is regarded a new generation of innovators representing diverse as the equivalent of the Nobel Prize in sectors in health. Our theme: better cross-cultural contacts, harmonized regulation, internal business biopharmaceutical research. process improvements, new information technologies and effective public-private partnerships can remove barriers to the commercialization of good medicines and The Prix Galien is more than an award: it is a expand access to these benefits to all who need them. movement with a mandate to foster, recognize and reward excellence in scientific innovation to improve the state of human health. Building on an unrivaled 2018 network of Top biomedical scientists including Nobel Through our partnership with the Élie Wiesel Foundation Laureates in medicine, the Prix Galien manages an for Humanity and our first initiative in Africa, 2018 will independent, cross-functional and geographically represent a new and exciting stage in the evolution of diverse program of events and sponsorships to the Prix Galien as the pre-eminent “force populaire” brand “the best of the best” in new medicines and behind the global scientific enterprise. With the support diagnostics. of our sponsoring organizations, our efforts will extend to all who see medical innovation not only as an Our scope is global, and our commitment to industrial policy asset but as a source of social progress progress in medicine is both measurable and concrete. – where private enterprise and public engagement Our members express this through the establishment combine to deliver a greater public good. of productive relationships to build lasting bridges between the commercial research enterprise and local We invite all communities with a commitment to the communities engaged in public policy, science, finance, conduct and promotion of life sciences innovation to academic research and the media. contribute to this important work. In addition to recognizing advances in promising therapies, the Prix Galien’s annual Pro Bono Humanum * Belgium, Canada, China, France, Germany, Greece, Italy, Award for humanitarian achievements brings a unique Netherlands, Poland, Russia, Spain, Switzerland, United focus to the intersection between science, business Kingdom and the . 3 Elie WIESEL In Memoriam Honorary Founding President The Galien Foundation Peace Nobel Laureate Boston University

Committee 2007-2011

Michael S. BROWN, MD Barry S. COLLER, MD Walter GILBERT, PhD Joseph GOLDSTEIN, MD Nobel Laureate Vice President for Nobel Laureate Nobel Laureate Professor of Molecular Medical Affairs Professor Emeritus Professor of Molecular Genetics and Internal Medicine and Physician-in-Chief, Harvard University Genetics and Internal Medicine UT Southwestern Rockefeller University UT, Southwestern Medical Center at Dallas Medical Center at Dallas

Paul GREENGARD, PhD Eric R. KANDEL, MD Joshua LEDERBERG, M.D. Ph.D. Richard A. LERNER, M.D. Nobel Laureate Nobel Laureate Nobel Laureate Professor of Immunochemistry, Professor of Molecular Professor of physiology Professor Emeritus, Chair in Chemistry and Cellular Neuroscience and Cellular Biophysics Laboratory of Molecular Genetics Scripps Research Institute Rockfeller University Columbia University and Informatics, Rockefeller University

Paul A. MARKS, MD Bengt SAMUELSSON, MD, PhD Jan T. VILCEK, M.D. Gerald WEISSMANN, M.D. Laboratory Head of Cell Biology Nobel Laureate Professor of Microbiology Professor of Rheumatology Memorial Sloan Kettering Professor Karolinska Institutet; University School and Director of Biotechnology Cancer Center Former President Karolinska of Medicine Study Center Institutet; Former Chairman New York University School Nobel Foundation of Medicine 4 AWARDS COMMITTEE 2018

Susan DESMOND-HELLMANN, MD, MPh Richard AXEL, MD Michael S. BROWN, MD Laurie GLIMCHER, MD Committee Chair Nobel Laureate Nobel Laureate President and CEO Dana Farber Cancer Institute; Chief Executive Officer Co-director Professor of Molecular Genetics Professor of Medicine Bill & Melinda Gates Foundation The Kavli Institute for Brain and Internal Medicine Harvard Medical School Science. Columbia University UT Southwestern Medical Medical Centre Center at Dallas

Joseph GOLDSTEIN, MD Robert S. LANGER Cato T. LAURENCIN, MD, PhD Paul A. MARKS, MD Nobel Laureate David H. Koch Institute Professor University Professor Laboratory Head of Cell Biology Professor of Molecular Genetics MIT University of Connecticut Memorial Sloan Kettering and Internal Medicine Cancer Center UT, Southwestern Medical Center at Dallas

Michael ROSENBLATT, MD Bengt SAMUELSSON, MD, PhD Marc TESSIER-LAVIGNE, PhD P. Roy VAGELOS, MD Chief Medical Officer Nobel Laureate President Prix Galien USA Flagship Pioneering at Dallas Professor Stanford University Committee Chairman 2012-2017 Karolinska Institutet; Retired Chairman and CEO Former President Merck & Co., Inc.; Karolinska Institutet; Chairman of the Board Former Chairman Regeneron Pharmaceuticals, Inc. Nobel Foundation 5 Galien FORUM october 25, 2018 - 7:30AM ALEXANDRIA CENTER FOR LIFE SCIENCE NEW YORK CITY

The Galien Forum, held every autumn at New York’s Alexandria Center for Life Sciences since 2010, offers a full day of dynamic presentations and spirited discussions with top scientists and industry researchers who offer perspectives on the most significant challenges in the global burden of disease and highlight the latest research and clinical pathways toward diagnosis, treatment, and cure.

Topics debated at previous forums include: Our 700 attendees represent the top executive and thought > Cancer Immunotherapeutics leadership from academic research, industry, government, the regulatory community, patient organizations, international > The Brain Initiative organizations, and the media. Time and again, Forum participants > Personalized Medicine’s Impact on Drug R&D and Patient Care praise the caliber of the speakers and their fellow attendees, > Improving efficiency in Drug Development the quality of the panel discussions and presentations, and > What is “Value” and How Can it be Measured and the recognition of industry’s critical role in creating life-saving innovations. Demonstrated in Therapeutic Innovations? > U.S. Health Reform These events represent peer-to-peer exchange with a public > A New Agenda for Global Health purpose, and they feature unique opportunities to connect with > The Future of Digital Health and its Impact on Healthcare a diverse range of people, organizations, and interests, from professional and scientific groups, academia and governments to > New Mechanisms for Industry-Academia Collaboration patient associations, non-profit organizations and the media. > The Future of Targeted Drug Delivery > Microbiota in Human Disease Visit the forum webcast to read our > Autism - The Next Decade 2017 Forum Report on people and substance and to see videos and > Untangling the Web of Neurodegeneration photos from the event > Precision Medicine: Delivering on the Promise > Molecular Scissors: What Can We Expect from Gene Editing? 6 AMONG THE PREVIOUS GALIEN FORUM SPEAKERS

Richard Axel, MD Cori Bargmann PhD Michael Bloomberg Michael S. Brown Dr Samantha Budd Rory Collins Mikael Dolsten, MD, PhD Nobel Laureate Rockefeller University Former Mayor Nobel Laureate Vice President Co-director President, Worldwide Co-director City of New York Professor of Molecular Neuroscience iMed, University of Oxford Research and Development Kavli Institute Genetics and Internal AstraZeneca R&D Clinical Trials Unit Pfizer for Brain Science, Medicine Columbia University UT Southwestern Medical Medical Centre Center at Dallas

Ezekiel Emanuel, MD, PhD Kenneth C. Frazier Maria C. Freire, PhD Laurie Glimcher, MD Joseph Goldstein Dr Alex Gorsky Vice Provost for Global Chaiman, CEO and President & Executive CEO and President Nobel Laureate Chaiman and CEO Initiatives; Chair, President, Director Dana Farber Cancer Professor of Molecular Johnson & Johnson Dept. of Medical Ethics Merck Foundation for the National Institute; Genetics and Internal and Health Policy Levy Institutes of Health Professor of Medicine Medicine University Professor Perelman Harvard Medical School UT, Southwestern Medical School of Medicine and The Center at Dallas Wharton School, University of Pennsylvania

Paul Greengard, PhD William N. Hait, Margaret A. Hamburg, MD Eric R. Kandel, MD Sachin H. Jain, MD, MBA Nobel Laureate MD, PhD Former Commissioner Nobel Laureate Chief Medical information Professor of Molecular Global Head, Research U.S. Food and Drug Professor of Physiology and innovation officer and Cellular Neuroscience and Development Administration and Cellular Biophysics Merck and Co.; Rockefeller University Janssen Research Columbia University; Lecturer in Healthcare & Development Director Bio-technology Policy Harvard Medical Study Center, NYU School School of Medicine

John Lechleiter Dr Jeffrey Leiden Donald Lloyd-Jones Joel S. Marcus Mark McClellan, MD, PhD Dr Ira Mellman Tara Narula, MD, FACC Chairman and CEO Chairman, President Chairman, Department Chairman, CEO & Founder Director Vice President Medical Contributor Eli Lilly & Cie and CEO of Preventive Medicine Alexandria Real Estate Duke-Robert J. Margolis Research Genentech “CBS This Morning” Veritex Northwestern University Equities / Center for Health Policy; Alexandria Venture Professor of Business, Investments; Co-Founder Medicine, and Health Policy Alexandria Summit Duke University

Guido Rasi Michael Rosenblatt, MD Bengt Samuelsson, George A. Scangos, PhD Dr Morgan Sheng Steven H. Stein, MD Executive Director Chief Medical Officer MD, PhD Chief Executive Officer Vice President Senior Vice President European Medicines Flagship Ventures Nobel Laureate Biogen Idec Neuroscience Genentech US Clinical Development Agency Former President & Medical Affairs Karolinska Institute Novartis Oncology US Former Chairman Nobel Foundation

Marc Tessier-Lavigne PhD P. Roy Vagelos Bert Vogelstein George Yancopoulos, Krishna Yeshwant, MD Elias Zerhouni President M.D., Retired Chairman Professor MD, PhD General Partner President, Global R&D Stanford University and CEO, Merck & Co., Inc. Johns Hopkins Medical Chief Scientific Officer Google Ventures Sanofi Chairman of the Board, School Regeneron Pharmaceuticals Regeneron Pharmaceuticals President, Regeneron Laboratories

7 “I applaud Prix Galien for recognizing the pioneering spirit of America innovation and research.“

John McCain American Senator - 2008

“The Prix Galien USA recognizes the important research necessary to develop innovative medicines and devices that have a life-saving impact on individuals and families across the globe.“

Kathleen Sebelius American Secretary of Health and Human Services - 2011 “We recognize the importance of the Prix Galien in promoting drug research, and we salute the excellent work of the Jury.“

Philippe Douste-Blazy French Minister of Foreign Affairs – 2006

“I’d also like to congratulate all the candidates for the 5th Annual Prix Galien Awards Competition, which honors those in the pharmaceutical industry who “When Olympic rhymes with Galenic: have developed the technical, scientific there is a gold medal that can be won and clinical research skills necessary for an extraordinary achievement: to develop innovative medicines and this is the Galien Award, the Oscar of devices. Your work is invaluable.“ pharmaceutical research.“ Margaret A. Hamburg, M.D. Walter Sutter Commissioner of Food and Drugs Swiss State Advisor, Director US Food and Drug Administration - 2011 of the Public Economy - 2004

“The Galien Foundation, created to honor and catalyze excellence in scientific innovation, recognizes outstanding achievement with the prestigious Prix “Prix Galien recognizes men and women Galien Award.“ from the pharmaceutical and biomedical industries whose contributions of science Bill De Blasio have improved and saved countless lives.“ Mayor of the City of New York - 2015

Michael Bloomberg 8 Mayor of the City of New York - 2010

A record of leadership in bringing

the best of biomedical discovery to the attention“ of the world… “

“The Prix Galien is the right event, on the “I welcome you to the annual Prix right issue at the right time. I thank the Galien awards for innovative excellence Galien Foundation for bringing us together in biomedical products and health and for recognizing that a healthier world is technologies. The awards are among a safer world and a more just world.“ the highest honors in science and commerce..“ BAN Ki-moon UN Secretary-General - 2010 Jimmy Carter American President - 2017

“I am particularly grateful to receive this Award.“

“The Prix Galien is a prestigious award, Bill Clinton a magnificent occasion to pay American President - 2010 recognition to our researchers and to encourage our industry.“

Jean Chretien Canadian Prime Minister - 1994

“It is a pleasure to congratulate all “I know the importance of the Prix Galien those who promote the Prix Galien and which rewards every year therapeutic pharmaceutical research: they play a vital innovations and research works among role in the fight against disease throughout the most creative.“ the world.“

Emmanuel Macron John Major French President - 2018 British Prime Minister - 1996

“The Prix Galien since 1970 is dedicated “The Prix Galien is a welcome to promoting the research initiative to stimulate creative and development of the medicine research and promote excellence.“ and medicine industries.“

Barack Obama Macky Sall American President - 2008 Senegalese President - 2018 9 PRIX GALIEN Hall of fame Around the globe since 1970

BY NUMBER OF MEDALS

51 Merck 6 Astra-Zeneca, Inserm, Vertex

45 Novartis 5 Gilead Sciences, Lilly

42 Roche 4 Biogen, Institut Pasteur, Takeda

37 Sanofi 3 Actelion, Alexion, Almirall, Teva

35 GlaxoSmithKline 2 AP-HP, Celgene, Chiesi, CTRS, Edwards Life-sciences, Fresenius Biotech, Genzyme, Institut Merieux, Ipsen, 32 J&J/Janssen Lundbeck, Pierre-Fabre, Procter & Gamble, PTC Thera- peutics, Shire Pharmaceuticals 28 Pfizer 1 AAZ, AbbVie, Abbott/AbbVie, Albana Pharma, Army 23 Bristol-Myers Squibb Health Department - France, Astellas, Baxter, Biocodex, Boston Scientific, Centre of Polymer and Carbon Materi- 17 als of the Polish Academy of Sciences, Chugaî, Engel- hardt Institute of Molecular Biology, EOS Imaging, Ferrer, 16 Amgen Genethon, Genentech, Generium, Guerbet, Institut Santa Creu, Intercept Pharmaceuticals, Insightec, Intermunde, 11 Abbott, Servier Ionis Pharmaceuticals, Leo, LFB, Menarini, Norgine GmbH, Orphan, Otzuka, PharmaPharm, Roche/Genen- 8 Boehringer Ingelheim tech, Swedish Orphan International, T2 Biosystems, Uriach, Viron Therapeutics,

Updated December 2017

The Medal by Albert de JAEGER

The Prix Galien medal was designed by Albert de Jaeger (1908 – 1992), laureate of the Premier Grand Prix de Rome architectural prize. De Jaeger designed medals for prominent figures such as Pope Pius XII (at the Villa Medicis, 1937) and Pope Jean-Paul I, Presidents Dwight D. Eisenhower and John F. Kennedy, distinguished military leaders including Marshals Leclerc, Koenig, Montgomery, Marshall and Joukov; the Weizmann Institute, as well as numerous artists, literary figures and prominent personalities such as Sacha Guitry, Marcel Proust, Henri de Montherlant, Paul Harris, a number of Nobel Prize laureates, the Empress of Iran SA Farah Diba, Princess Grace of Monaco, and others…

De Jaeger is also the architect of numerous outstanding monuments in France and throughout the world.

10 Our annual gala awards dinner is a creative Galien AWARDS recognition of the productive and positive power of partnerships that drive progress in medical CEREMONY 2018 science. It is peer exchange with a public purpose - with a diverse range of opportunities for contact with a range of interests, from professional and october 25, 2018 scientific groups, academia and governments 6:30 PM to patient associations, other non-profit organizations and the media. AMERICAN MUSEUM OF NATURAL HISTORY NEW YORK CITY

WHAT PREVIOUS “Merck’s mission is to “Our 2016 Prix Galien USA translate science into awards [for Cosentyx and PRIX GALIEN medically important Gleevec] … represent years WINNERS HAVE products that positively of hard work by our scientists. SAID UPON impact humanity, so it is These wins underscore our RECEIVING THE natural for us to support the Prix commitment to addressing the Galien, since it supports exactly that.” unmet medical needs of patients through HONOUR science-based innovation.” Kenneth C. Frazier Chaiman, CEO and President Joseph Jimenez Merck CEO Novartis

“The Galien Foundation “Our 2016 Prix Galien award “Our goal — to combine the brings together the top highlights not only the best science with the most scientists in the world. breakthrough science behind efficient drug development You have Nobel Laureates Cologuard, but also the plan and deliver across the spectrum of unrivaled team that worked to transformational medicines to scientific disciplines meeting and develop and bring to market an innovation patients in need — is completely aligned talking with members of the pharmaceutical with the potential to make a significant with the Galien Foundation mission to industry to see what’s going on at the impact in eradicating colorectal cancer. We promote innovations that improve the cutting edge, because ultimately that’s are humbled and thankful to be counted human condition.” going to benefit patients.” among the companies honored by the Galien Foundation.” Mace L. Rothenberg, William Hait, MD, PhD M.D. Chief Development Officer, Oncology - Global Head, Research & Development Graham Lidgard, PhD Pfizer Global Product Development Janssen, Pharmaceutical Companies of Chief Science Officer Johnson & Johnson Exact Sciences 11 The committee follows a century-old example set in . The Prix Galien rewards excellence and novelty, and awards special honors to those who have served humanity at large. Presented at the Ceremony, the Pro Bono Humanum Award recognizes exemplary and innovative efforts in improving the human condition. This special award was presented by the late and beloved Elie Wiesel, in presence of the Prix Galien USA Committee.

2017 countries. This includes the eradication of the Guinea worm President Jimmy Carter & The Carter Center disease as well as the MECTIZAN initiative to control the In recognition of his role as the nation’s 39th President in scourge of river blindness in Africa and Latin America, which expanding access to childhood immunizations and, for the today serves as a precedent for productive public-private first time, adding social progress and human rights as a partnerships. The Committee points as well to his selection foundational principle of US foreign policy. The Prix Galien as recipient of the Nobel Peace Prize in 2002, USA Committee also commends his unmatched record in in which the Swedish Academy noted his decades of effort public health provision after leaving office, launching the to promote individual freedoms and economic and social Carter Center in 1982 and subsequently positioning it as a development for all. These are now recognized around the leading global donor on programs to control and eradicate world as important drivers of individual health status. six major communicable diseases prevalent in developing

2016 2015 2014 2013 2012 Paula S. Apsell Pr. Mary-Claire King Bernard Kouchner, M.D. Dr. Anthony Fauci Dr. Francis S. Collins. In recognition of her early and In recognition of your In recognition of his role in for his paramount Dr. Collins, Director of the continuing leadership in Making the work in transforming the the creation, from amongst contributions to basic and National Institutes of Health complexities of science, engineering application of human French doctors, this group of clinical research on the (N.I.H) and medical research accessible to a genetics to medicine through “Doctors Without Borders” pathogenesis and treatment In recognition of his mass audience. Through innovative identification of who have lent the modern of immunemediated and contribution to the ethical broadcast and digital programming the first gene, BRCA1, field of humanitarian infectious diseases. implications of scientific of the highest journalistic responsible for inherited medicine both legitimacy He currently serves as research standard, her work has educated, susceptibility to breast and worldwide acclaim and Director of the NIAID and entertained and enlightened cancer. You also for his fieldwork that has chief of the NIAID Laboratory successive generations of viewers demonstrated that the nurtured and developed, of Immunoregulation in on the mysteries that underlie our genomes of humans and not only among public Bethesda, Maryland. understanding of the natural world. chimpanzees are 99% opinion but also within And by turning great science into identical, and you pioneered various governments, the a good story - a human story - Ms. the application of genetic notion of the universality Apsell shows that scientific literacy sequencing in forensics to of humanitarian action and is society’s essential line of defense identify victims of human the concept of the Non- against the destructive forces of fear, rights abuse. Governmental Organization. ignorance and blight.

2011 2010 2009 2008 2007 Pr. Paul Farmer Bill Clinton and Harvard Professor Barry Bloom Sheldon Segal and the Former Merck CEO Roy in recognition of his Philippe Douste-Blazy, for bringing the fruits of basic for their Vagelos, for the River heroic efforts to do in recognition of their biological science to those global efforts in support of Blindness Program and “whatever it takes” to outstanding achievements who are most needy. Columbia reproductive health and family his historic decision improve the lives and in providing treatment for University Earth Institute Director planning. to donate the drug health of patients in underserved populations Jeffrey Sachs for bringing the Mectizan® to more than destitute communities through the William J. Clinton fruits of scholarly economics 530 million people in 34 around the world Foundation HIV / AIDS to bear our problems that have countries to treat and through the Partners in Initiative and the multilateral plagued the world for millennia. prevent river blindness: Health initiative which organization, UNITAID. “as much as necessary for he co-founded with as long as necessary.” Tom White.

12 An UNRIVALED REPUTATION FOR INTELLECTUAL RIGOR AND INTEGRITY…

The Prix Galien USA Committee, a group of highly accomplished individuals from the scientific and research communities, will judge which among the candidates, independent of any category, is the Best Pharmaceutical Agent (i.e. small molecule), is the Best Biotechnology Product and which is the Best Medical Technology approved by the FDA in the past ten years. As few as one or as many as three prizes may be awarded in each of these categories, and from time to time the committee may decide on awards hors prix. The prizes are awarded for products and agents that improve the human condition.

Elie Wiesel, Peace Nobel Laureate; BAN Ki-moon, General Secretary, United Nations; Bill Clinton & Philippe Douste-Blazy, 2010 Prix Galien Pro Bono Humanum Award Laureate Who was Galien?

Born in 131AD, Galen (Galien in French) is inspired the direction of his life. When he world, studying local plants and remedies, considered the father of modern medicine was 17, Galen worked as a physician to eventually describing 473 original drugs and and pharmacology.As an anatomist, the gladiatorial school. At the age of 37, many substances of mineral and vegetable physiologist, clinician and researcher, Marcus Aurelius summoned him to Rome, origin. Importantly, Galen was the first to his work formed the basis of a school where he grew in reputation and stature codify the art of preparing active drugs of thought known as “Galenism”, which as a healer, teacher, researcher and writer. using multiple ingredients. Galen’s faculties dominated medicine until the Renaissance. His ideas on the functioning of the human of observation, logic and deduction made In fact, Galen’s works were used as primary body were so well received that he became him the true successor of Hippocrates, medical reference for nearly two centuries. the personal doctor of young Commodus, and his declaration that the primary aim of the heir to the Emperor. He died in 201AD. medicine was patient care formed the very Raised in Pergamos, he studied in Smyrna, During his long and eminent career, Galen cornerstone of modern pharmacy.To quote Corinth, and Alexandria, the three centers completed over five hundred learned works Jean-Pierre Changeux, “Galen first showed of medical excellence in the ancient world. addressing anatomy, physiology, pathology, that our mind was in the brain, not in our Legend has it that Galen was visited medical theory and practice, and many hearts.” It can be said that this was the by Aesclapius in a dream and that this forms of therapy. He traveled throughout the beginning of experimental medicine. 13 The mission of The Prix Galien-MedStartUp program is to foster private-sector collaborations to treat and cure medical conditions that pose a threat to public health worldwide and promotes foster innovative research partnerships among major integrated pharmaceutical companies, biotech firms, and medical device manufacturers, producers of vaccines, academic research institutes, and health care organizations, including e-health vendors.

This unique initiative, which takes place in Best Collaboration/Partnership with an the same venue and at the same time as the Academic institution in a Breakthrough Galien Forum, was built on several years of Therapy cooperation between the Galien Foundation and Business France with three core goals: A focal point of the program is the active Best Innovative Clinical Trial Design to achieve participation of the most innovative start-up a Faster and Better Therapeutic Outcome Strengthen commercial partnerships companies who are seeking US partners to that bridge the traditional silos between share research and support global commercial Best Use of a Patient-Centered Health government, industry and academia; development of promising lead technologies. Engagement Technology

Defray the growing complexity and cost Each year the Jury nominates candidates Best Collaboration/Partnership in a burden of medicines R&D; and for four awards in the following categories: Breakthrough Therapy or Diagnosis geared to Developing Countries. Promote cross-border trade, jobs, and economic growth.

THE JURY ! Chairman: Bernard POUSSOT Director, Roche Holding, Former Chairman & CEO,

! Roch DOLIVEUX ! François MAISONROUGE Honorary CEO, Senior Managing Director, UCB Evercore Partners

! Mikael DOLSTEN ! Paul STOFFELS Global R&D President, Chief Scientific Officer, Pfizer Johnson and Johnson

! Jean-Pierre GARNIER ! Elias ZERHOUNI Former CEO, Global R&D President, GSK Sanofi

! Franz HUMER Former CEO, JOIN US ON : Roche http://medstartup.galienfoundation.org +

14 PRIX GALIEN USA WINNERS And in 2018, the winners are…

2017 2016 2015 Best Pharmaceutical Product: Best Pharmaceutical Agent: Best Pharmaceutical Agent: Venclexta™, AbbVie & Genentech Ibrance®, Pfizer, Inc. IMBRUVICA®, Janssen Biotech, Inc. (a Member of the Roche Group) Best Biotechnology Product: & Pharmacyclics LLC, an AbbVie Cosentyx®, Novartis Pharma. Company Best Biotechnology Product: ® SPINRAZA , Biogen & Ionis Best Medical Technology: Discovery of the Decade winners: Best Biotechnology Product: ® Pharmaceuticals Cologuard , Exact Sciences Best Pharmaceutical Agent: OPDIVO®, Bristol-Myers Squibb Gleevec®, Novartis Pharma. KEYTRUDA®, Merck & Co., Inc. Best Medical Technology: Best Biotechnology Product: Exablate Neuro, INSIGHTEC ® Best Medical Technology: Yervoy , Bristol-Myers Squibb T2Candida Panel, T2 Biosystems, Pro Bono Humanum Award: Best Medical Technology: Inc. Former President Jimmy Carter Sapien 3TM, Edwards Lifesciences Corpo. Pro Bono Humanum Award: Pr. Mary-Claire King Pro Bono Humanum Award: Paula S. Apsell

2014 2013 2012 2011 Best Pharmaceutical Agent: Best Pharmaceutical Agents: Best Pharmaceutical Agents: Best Pharmaceutical Agent: Sovaldi® - Gilead Sciences Zelboraf® - Genentech Victrelis® - Merck; Incivek® - Vertex Prevnar13® - Pfizer

Best Biotechnology Product: Best Biotechnology Product: Best Biotechnology Product: Best Biotechnology Product: ® ® ® HEMACORD - The New York Zostavax - Merck Yervoy - Bristol-Myers Squibb Stelara® - Janssen Blood Center’s Howard Prolia and XGEVA® - Amgen P. Milstein Cord Blood Center Best Medical Technology product: Best Medical Technology product: S-ICD® System - Boston Scientific Sapien® - Edwards Lifesciences’ Pro Bono Humanum Award: Best Medical Technology: Melody® - Medtronic Paul Farmer Trevo ProVue® - Stryker Pro Bono Humanum Award: Dr. Anthony S. Fauci Pro Bono Humanum Award: Pro Bono Humanum Award: Dr. Francis S. Collins Dr. Bernard Kouchner

2010 2009 2008 2007 Best Pharmaceutical Agent: Best Pharmaceutical Agent: Best Pharmaceutical Agent: Best Pharmaceutical Agent: Coartem® - Novartis Gleevec® - Novartis Isentress® - Merck; Januvia® - Merck; Selzentry® - Pfizer Chantix® - Pfizer Best Biotechnology Product: Best Biotechnology Product: ® Best Biotechnology Product: RotaTeq - Merck & Co. ® Nplate - Amgen; Soliris® - Alexion; Best Biotechnology Product: ® ® Best Medical Technology: Promacta - GSK Infuse® - Wyeth Humira - Abbott; ® xTAG ® - Luminex Corporation Gardasil - Merck Best Medical Technology: Special therapeutic development: ® Pro Bono Humanum Award: Cellsearch® - Veridex (J&J) Revlimid - Celgene Pro Bono Humanum Award: Bill Clinton and Dr. Roy Vagelos Pro Bono Humanum Award: Philippe Douste-Blazy Pro Bono Humanum Award: Sheldon Segal Jeffrey Sachs and Barry Bloom 15 OCTOBER 25, 2018 AMERICAN MUSEUM OF NATURAL HISTORY

and the winner is…

Actors win Oscars ... Innovators win Prix Galien USA

Exablate Neuro® 2017TM 2017 Spinraza® / Venclexta

2016Cologuard® / Cosentyx® 2016 Ibrance®

Imbruvica®/ Keytruda®/ 2015Opdivo® / T2Candida Panel 2015

HemacordTM / Trevo®ProVueTM 2014Sovaldi® 2014

S-ICD® System 2013Zelboraf® / Zostavax® 2013

Incivek® / Melody® / Sapien® 2012 2012 Victrelis® / Yervoy® 2011 Prevnar13® / Prolia and XGEVA® / Stelara® 2011

2010 Coartem® / Rotateq® / xTAG® 2010 2009 Cellsearch® / Gleevec® / Nplate® / Promacta® 2009

2008 Infuse® / Isentress® / Revlimid®/ Selzentry® / Soliris® 2008

2007 Chantix® / Gardasil® / Humira® / Januvia® 2007

The Galien Foundation 99 John Street, Suite 2502 The Galien Foundation New York, NY 10038 99 John Street , Suite 2502. Tel: 212-685-1592 New York, New York 10038 www.galienfoundation.org 212-685-1592