Nelarabine (Arranon) Datasheet | Buy Nelarabine (Arranon) from Supplier Selleckchem.Com

12/12/12 Nelarabine (Arranon) Datasheet | Buy Nelarabine (Arranon) from supplier Selleckchem.com

Nelarabine (Arranon) Datasheet

Technical Data Nelarabine (Arranon) Chemical Structure

DMSO 60 mg/mL Molecular Weight (MW) 297.27 Solubility (25°C) Water 3 mg/mL Formula C H N O 11 15 5 5 Ethanol <1 mg/mL

2 years -20°C Powder CAS No. 121032-29-9 Storage 2 weeks 4°C in DMSO Return Policy Synonyms Arranon 6 months -80°C in DMSO Selleck Chemicals wishes you the best possible online shopping experience with our 365 day unconditional Return Biological Activity Policy. If you are not satisfied with your Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor for HSB2 cell purchase, either for protocol related or Description lines and ALL-SIL cell lines with IC50 of 0.13 μg/mL and 0.37 μg/mL, respectively. product related problems, you may return any item(s) within 365 days from Targets HSB2 cell lines ALL-SIL cell lines JURKAT cell lines PER-255 cell lines the original purchase date. Please see the following instructions when you IC50 0.13 μg/mL 0.37 μg/mL 0.64 μg/mL [1] 0.02 μg/mL return products.

The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T- 1. All requests for returns should be ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. communicated to Selleck Chemicals In vitro The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, prior to shipping. Any items returned to respectively. [1] Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible Selleck Chemicals should be in the cells. [2]Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity. [3] original packaging and in the same condition as originally purchased. The Nelarabine plasma AUC is 2.82 mM minutes and the ara-G plasma AUC is 20 mM minutes. The 2. When returning purchased goods, terminal half-life of Nelarabine in plasma is 25 min, clearance is 42 mL/minutes/kg, and central volume please inform us of the purchase order of distribution is 1.1 L/kg. The terminal half-life of ara-G in plasma is 182 minutes and the central In vivo number or package tracking number. volume of distribution is 1.4 L/kg. In CSF the terminal half-life of Nelarabine is 77 minutes and of ara-G 3. Return shipping is absolutely FREE. is 232 minutes. The AUCcsf:AUCplasma is 29 % for Nelarabine and 23 % for ara-G. Nelarabine and 4. This offer is only valid for products [4] ara-G do not accumulate with daily infusions because of their relatively short half-lives. purchased directly from Selleck and its authorized distributors. Nelarabine plus Doxorubicin, Cyclophosphamide,Cytarabine, Dexamethasone, Methotrexate or 5. Once your return request is received Clinical Trials Vincristine has entered in a phase II clinical trial in the treatment of leukemia, acute lymphoblastic and approved, your refund will be leukemia, and lymphoblastic lymphoma. processed or automatically applied to Features Nelarabine is rapidly converted into ara-G through demethoxylation by adenosine deaminase. your credit card within 7 days. Please note that depending on your credit card company, it may take additional 2-10 Protocol (Only for Reference) business days for us to post the refund Cell Assay: sup>[1] to your account. Cell Lines HSB2, ALL-SIL, JURKAT and PER-255 cell lines Toll Free: Concentrations 0.125 μg/mL - 8 μg/mL (877) 796-6397 Incubation Time 96 hours -- USA and Canada only -- HSB2, ALL-SIL, JURKAT and PER-255 cell lines are tested for drug resistance using the MTT assay. Nelarabine are incubated over 4 days, with concentration tested in triplicate. The IC50 (drug concentration Fax: that inhibits cell growth by 50%) is used as the measure of drug resistance. Data represent the average of Methods +1-713-796-9816 2–6 experiments performed on separate occasions. In cases where 50% cytotoxicity is not achieved by even the highest dose in a particular experiment, the IC50 is recorded as double the highest concentration tested. Orders: +1-832-582-8158 Animal Study:[4] [email protected] Animal Models Healthy adult male rhesus monkeys

Formulation Control Tech Support: +1-832-582-8158 Doses 35 mg/kg Ext:3 Administration Administered via i.v. Monday–Friday 9:00 AM–5:00 PM (Central Time) References [email protected] [1] Beesley AH, et al. Br J Haematol. 2007, 137(2), 109-116. We will contact you within one business day [2] Kline J, et al. Expert Opin Pharmacother. 2006, 7(13), 1791-1799. [3] DeAngelo DJ, et al. Blood. 2007, 109(12), 5136-5142. Website: [4] Berg SL, et al. Cancer Chemother Pharmacol. 2007, 59(6), 743-747. www.selleckchem.com

PLEASE KEEP THE PRODUCT UNDER -20°C FOR LONG-TERM STORAGE.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products are stable under www.selleckchem.com/datasheet/Arranon-DataSheet.html 1/2 12/12/12 Nelarabine (Arranon) Datasheet | Buy Nelarabine (Arranon) from supplier Selleckchem.com

the recommended conditions. Products are sometimes shipped at a temperature that differs from the recommended storage temperature. Many products are stable in the short-term at temperatures that differ from that required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality, but save your shipping charges by using the most economical storage conditions for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product datasheet.