STAPLES LECTURESHIP in BIOCHEMISTRY 2018

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MOLECULAR & BIOMEDICAL SCIENCES STAPLES LECTURESHIP in BIOCHEMISTRY 2018 David Bartel’s research centers on RNA, with a special interest in microRNAs (miRNAs), short RNA molecules that regulate gene expression. He and his laboratory utilize a variety of methods that allowed them to discover the abundance of miRNAs, to investigate how miRNAs are made, and to predict which genes miRNAs regulate in both plants and animals. The Bartel Laboratory also has shown how a specific miRNA helps to prevent cancer and has contributed to the development of RNA as a tool for silencing gene expression. In addition, they have been studying messenger RNAs (mRNAs) and the functions of the tails added to the ends of most mRNAs. Dr. Bartel’s research has been recognized with the AAAS Newcomb Cleveland Prize (2002), the National Academy of Sciences Molecular Biology Award (2005) and the Institut de France Louis-D. Prize (2005). Dr. Bartel received his undergraduate degree from Goshen College (IN) before completing his doctorate in Virology at Harvard University. He subsequently joined the Whitehead Institute as a Whitehead Fellow and was appointed as an Associate Member of the Whitehead and Assistant Professor of Biology at MIT (1996). He was named an investigator of the Howard Hughes Medical Institute in 2005 and elected to the National Academy of Sciences in 2011. Dr. Bartel is currently an Investigator of the Howard Hughes Medical Institute, a Member at the Whitehead Institute and Professor of Biology at the Massachusetts Institute of Technology (MIT). David P. Bartel PUBLIC LECTURE Small RNAs that Regulate Genes and Treat Diseases Thursday November 15 4:30PM McIntire Room, Buchanan Alumni House Research Seminar 1 MicroRNAs and Other Regulatory RNAs Thursday November 15 11:00AM Arthur St. John Hill Auditorium, ERSB Research Seminar 2 The Dynamics of Cytoplasmic mRNA Metabolism Friday November 16 1:00PM Arthur St. John Hill Auditorium, ERSB All lectures are free and open to the public . For additional information contact the Department of Molecular and Biomedical Sciences 581-2810 The University of Maine is an equal opportunity/affirmative action institution. .

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2008-Annual-Report.Pdf
whitehead institute 2008 AnnuAl RepoRt. a year in the life of a scientific community empowered to explore biology’s most fundamental questions for the betterment of human health. whitehead institute 2008 annual report a Preserving the mission, contents facing the future 1 preserving the mission, it’s customary in this space to recount and reflect facing the future on the accomplishments of the year gone by. i’ll certainly do so here—proudly—but in many 5 scientific achievement important ways, 2008 was about positioning the institute for years to come. 15 principal investigators many colleges, universities, and independent 30 whitehead fellows research institutions found themselves in dire fiscal positions at the close of 2008 and entered 34 community evolution 2009 in operational crisis reflective of the global economic environment. hiring freezes and large- 40 honor roll of donors scale workforce reductions have become the norm. although whitehead institute is certainly not 46 financial summary insulated from the impact of the downturn, i am 48 leadership pleased and somewhat humbled to report that the institute remains financially strong and no less 49 sited for science committed to scientific excellence. david page, director over the past two years, we have been engaged in a focused effort to increase efficiency and editor & direCtor reduce our administrative costs, with the explicit goal of ensuring that as much of the institute’s matt fearer revenue as possible directly supports Whitehead research. Our approach, which has resulted in assoCiate editor nicole giese a 10-percent reduction in operational expense, has been carefully considered. every decision offiCe of CommuniCation and PubliC affairs has been evaluated not just for its potential effects on our scientific mission, but also for 617.258.5183 www.whitehead.mit.edu possible consequences to the whitehead community and its unique culture.
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Dr. David P. Bartel Journal Interviews
Home About Scientific Press Room Contact Us ● ScienceWatch Home ● Interviews Featured Interviews Author Commentaries Institutional Interviews 2008 : June 2008 - Author Commentaries : Dr. David P. Bartel Journal Interviews Podcasts AUTHOR COMMENTARIES - 2008 ● Analyses June 2008 Featured Analyses Dr. David P. Bartel A Featured Scientist from Essential Science IndicatorsSM What's Hot In... Special Topics Earlier this year, ScienceWatch.com published an analysis of high-impact research in Molecular Biology & Genetics over the past five years. The ● Data & Rankings analysis ranked David Bartel #2 among authors publishing high-impact papers in this field, based on 19 papers cited a total of 4,542 times. Sci-Bytes In Essential Science Indicators from Thomson Reuters, Dr. Bartel's record Fast Breaking Papers includes 76 original articles and review papers published between January 1, New Hot Papers 1998 and February 29, 2008, with a total of 10,386 cites. These papers can be found in the fields of Molecular Biology & Genetics, Biology & Emerging Research Fronts Biochemistry, and Plant & Animal Science. Fast Moving Fronts Research Front Maps Current Classics Dr. Bartel is a Howard Hughes Medical Institute investigator whose lab is based at the Whitehead Institute Top Topics for Biomedical Research in Cambridge, Massachusetts. He is also a Professor in the Department of Biology at MIT. Rising Stars New Entrants In the interview below, he talks with correspondent Gary Taubes about his highly cited research. Country Profiles What motivated your research originally on these small, non-coding RNAs, and particularly the 2000 Cell paper (Zamore PD, et al., RNAi: double-stranded RNA directs the ATP-dependent ● About Science Watch cleavage of mRNA at 21 to 23 nucleotide intervals," 101[1]: 25-33, 31 March 200), which is your most-highly cited paper that’s not a review? Methodology Tom Tuschl and Phil Zamore [see also] were postdocs in my lab working in collaboration with Phil Sharp Archives [see also] on the biochemistry of RNAi.
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Fire Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Room L235, Stanford, CA 94305-5324, USA
GENE SILENCING BY DOUBLE STRANDED RNA Nobel Lecture, December 8, 2006 by Andrew Z. Fire Departments of Pathology and Genetics, Stanford University School of Medicine, 300 Pasteur Drive, Room L235, Stanford, CA 94305-5324, USA. I would like to thank the Nobel Assembly of the Karolinska Institutet for the opportunity to describe some recent work on RNA-triggered gene silencing. First a few disclaimers, however. Telling the full story of gene silencing would be a mammoth enterprise that would take me many years to write and would take you well into the night to read. So we’ll need to abbreviate the story more than a little. Second (and as you will see) we are only in the dawn of our knowledge; so consider the following to be primer... the best we could do as of December 8th, 2006. And third, please understand that the story that I am telling represents the work of several generations of biologists, chemists, and many shades in between. I’m pleased and proud that work from my labo- ratory has contributed to the field, and that this has led to my being chosen as one of the messengers to relay the story in this forum. At the same time, I hope that there will be no confusion of equating our modest contributions with those of the much grander RNAi enterprise. DOUBLE STRANDED RNA AS A BIOLOGICAL ALARM SIGNAL These disclaimers in hand, the story can now start with a biography of the first main character. Double stranded RNA is probably as old (or almost as old) as life on earth.
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Whitehead Faculty and Fellows Members
Whitehead Faculty and Fellows Members Ask a visiting scientist to describe Whitehead Institute and three themes David Bartel studies microRNAs and other small RNAs emerge immediately: the exceptional quality of the scientific staff, the that specify the destruction and/or translational collaborative spirit, and the ethos that encourages researchers at every level repression of mRNAs. He also studies mRNAs, focusing to share new ideas and benefit from the insights and experience of their on their untranslated regions and poly(A) tails, and colleagues. how these regions recruit and mediate regulatory processes. His lab found that microRNAs affect most human protein-coding genes, either by regulating The key to this combination of excellence and accessibility is, of course, the them or by shaping their evolution. Faculty. “From the beginning, we sought researchers who had terrific scientific instincts, but we were also looking for people who would feel comfortable in Iain Cheeseman investigates the process of our open environment,” says Founding Member Gerald Fink. “The exchange chromosome segregation and cell division. In of energy and new ideas never stops, from the formal research retreat, to the particular, he uses proteomics, biochemistry, cell faculty lunches, to the countless informal conversations in hallways and biology, and functional approaches to examine the lounges.” composition, structure, organization and function of the kinetochore — the group of proteins that assemble Whitehead Institute faculty, known as Members, are selected through a joint at the centromere and are required for chromosome appointment process with the Massachusetts Institute of Technology (MIT) segregation and cell division. Department of Biology. Whitehead Institute is solely responsible for their salary and research.
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Micrornas Generate Gene Expression Thresholds with Ultrasensitive Transitions
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Computational and experimental analysis of plant microRNAs by Matthew W. Jones-Rhoades B.A., Chemistry (1999) Grinnell College Submitted to the Department of Biology in Partial Fulfillment of the Requirement for the Degree of Doctor of Philosophy in Biology MASSACHUSETTSINSTATE at the OF TECHNOLOGY Massachusetts Institute of Technology MAY 2 7 2005 June 2005 LIBRARIES © 2005 Massachusetts Institute of Technology All rights reserved Signatureof Author.................................... ................. ................. Department of Biology x.. '"---.~ May 20, 2005 Certified by ......... · .................................................... David P. Bartel Professor of Biology Thesis Supervisor Acceptedby ... ......... Stephen P. Bell Professor of Biology Chairman, Graduate Student Committee ,' tti v ;S Computational and experimental analysis of plant microRNAs Matthew W. Jones-Rhoades Submitted to the Department of Biology on May 20, 2005 in Partial Fulfillment of the Requirement for the Degree of Doctor of Philosophy in Biology ABSTRACT MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs that mediate gene regulation in plants and animals. We demonstrated that Arabidopsis thaliana miRNAs are highly complementary (0-3 mispairs in an ungapped alignment) to more mRNAs than would be expected by chance. These mRNAs are therefore putative regulatory targets of their complementary miRNAs. Many miRNA complementary sites are conserved to the monocot Oryza sativa (rice), implying evolutionary conservation based on function at the nucleotide level. The majority of predicted miRNA targets encode for transcription factors and other proteins with known or inferred roles in developmental patterning, implying that the miRNAs themselves are high-level regulators of development. Our findings indicated that miRNAs are key components of numerous regulatory circuits in plants and set the stage for numerous additional experiments to investigate in depth the significance of miRNA-mediated regulation for particular target families and genes.
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(12) United States Patent (10) Patent No.: US 8,790,922 B2 Tuschl Et Al
USOO8790922B2 (12) United States Patent (10) Patent No.: US 8,790,922 B2 Tuschl et al. (45) Date of Patent: *Jul. 29, 2014 (54) RNASEQUENCE-SPECIFIC MEDIATORS OF 5,576,208 A 11/1996 Monia et al. RNA INTERFERENCE 5,578,716 A 1 1/1996 Szyfetal. 5,580,859 A 12/1996 Felgner et al. 5,594,122 A 1/1997 Friesen (75) Inventors: Thomas Tuschl, Brooklyn, NY (US); 5,624,803 A 4/1997 Noonberg et al. Phillip D. Zamore, Northborough, MA 5,624,808 A 4/1997 Thompson et al. (US); Phillip A. Sharp, Newton, MA 5,670,633. A 9, 1997 Cook et al. 5,672,695 A 9, 1997 Eckstein et al. (US); David P. Bartel, Brookline, MA 5,674,683 A 10, 1997 KOO1 (US) 5,712.257 A 1/1998 Carter 5,719,271 A 2f1998 Cook et al. (73) Assignees: Max-Planck-Gesellschaft zur 5,770,580 A 6/1998 Ledley et al. Forderung der Wissenschaften E.V. 5,795,715 A 8, 1998 Livache et al. Munich (DE); Massachusetts Institute 5,801,154 A 9, 1998 Baracchini et al. 5,814,500 A 9, 1998 Dietz of Technology, Cambridge, MA (US); 5,898,031 A 4/1999 Crooke Whitehead Institute for Biomedical 5,908,779 A 6/1999 Carmichael et al. Research, Cambridge, MA (US); 5,919,722 A 7/1999 Verduijn et al. University of Massachusetts, Boston, 5,919,772 A 7/1999 Szyfetal. 5,972,704 A 10/1999 Draper et al. MA (US) 5.998,203 A 12/1999 Matulic-Adamic et al.
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Xuebing Wu, Ph.D
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