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S2 Cells Infected S2 Cells Total Reads (18 28Nt) 22 375 548 18 059

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S2 Cells Infected S2 Cells Total Reads (18 28Nt) 22 375 548 18 059 &'(' !"#$% Supplemental Table II: List of genes induced by DCV, FHV and SINV DCV specific (82 genes) Probe number Gene name Synomymus DCV * Putative function Key words 143500_at rho 12.5 signal transduction 153603_at CG10927 4.9 Unknown Cytidine/deoxycytidylate deaminase zinc-binding region 151144_at CG13553 4.2 152245_at CG13335 3.6 151473_i_at syt synaptotagmin p65 3.4 enzyme 143125_at dl dorsal 3.3 DNA binding NF-kappa-B/Rel/dorsal 150552_at CG9996 3.1 Unknown Glycosyl transferase family 8 143770_at Mtk Metchnikowin 3.0 Antifungal peptide activity 141691_at spz spatzle 3.0 Toll binding 141444_at CG2471 3.0 actin binding Leucine-rich repeat 141366_at CG10764 serine protease 3.0 serine-type endopeptidase activity Peptidase trypsin-like serine and cysteine proteases 154443_at CG1667 2.9 unknown 151661_s_at Nrt Neurotactin 2.8 cell adhesion Esterase/lipase/thioesterase 141718_at D12 2.8 transcription factor YEATS family 147495_at CG10081 2.8 Unknown Peptidase M28 143869_at vri vrille 2.8 RNA polymerase II transcription factor activity Basic-leucine zipper (bZIP) transcription factor 151648_at CalpB Calpain-B 2.7 calpain activity Peptidase C2 calpain 152979_at CG31531 2.7 152405_at CG6014 2.7 Unknown C-type lectin 147951_at CG13905 2.7 154983_at CG15634 2.7 AICARFT/IMPCHase bienzyme, Methylglyoxal synthase-like 153761_at CG11089 2.6 Unknown domain 141974_at CG4573 2.6 tyrosine--tRNA ligase; enzyme 153004_at CG8603 2.6 motor 153432_at Thor Thor 2.6 Eukaryotic initiation factor 4E binding Eukaryotic translation initiation factor 4E binding 142200_at CG32477 2.5 151361_at RhoGAP18B 2.5 GTPase activator activity Rho GTPase activation protein 148533_at ninjurin A ninjurin 2.5 cell adhesion 142429_at CG14089 2.5 Collagen triple helix repeat 142097_at Myosin 31DF myosin I 2.5 Actin binding Myosin head (motor domain), IQ calmodulin-binding region 154415_at CG3279 2.5 v-SNARE activity Vesicle transport v-SNARE Fibronectin type III, Immunoglobulin-like, Peptidase M14 143665_at fra frazzled 2.5 netrin receptor activity carboxypeptidase A 153174_at CG9925 2.5 Maternal tudor protein, Zn-finger MYND type 151557_i_at CG32737 2.5 144197_at rdgB 2.5 phosphatidylinositol transporter activity Phosphatidylinositol transfer protein 147151_at CG18279 2.4 155065_at hdc headcase 2.3 signal transduction 151217_at U snoRNA host gene 1 2.3 151871_at CG30494 2.3 ligand binding or carrier Zn-finger C2H2 type, Cytochrome c heme-binding site, 144505_at CG32767 2.3 Nucleic acid binding Immunoglobulin/MHC 152889_at dei delilah 2.3 transcription factor activity Basic helix-loop-helix dimerization domain bHLH Eukaryotic protein of unknown function DUF292, Pancreatic 153798_at CG10103 2.3 transcription factor ribonuclease General substrate transporter, Sugar transporter 154436_at rtet tetracycline resistance 2.3 sugar porter activity superfamily 147575_at CG18413 2.3 1-phosphatidylinositol-45- 1-phosphatidylinositol-45-biphosphate 142250_at norpA 2.3 biphosphate phosphodiesterase phosphodiesterase ; EC:3.1.4.11 153304_at bip1 2.2 145526_at CG4213 2.2 motor 148109_at CG12014 2.2 iduronate-2-sulfatase activity Sulfatase 153934_at CG12190 2.2 transcription factor Zn-finger Ran-binding 153814_at CG17612 2.2 nucleic acid binding Zn-finger C2H2 type 143293_at pbl pebble 2.2 guanyl-nucleotide exchange factor activity Rhodopsin-like GPCR superfamily Dynein heavy chain, Peptidase eukaryotic cysteine 143726_at Dhc93AB Dynein heavy chain at 93AB 2.2 Dynein_heavy;microtubule motor activity peptidase active site, AAA ATPase 155084_at CG17260 2.2 nucleic acid binding Zn-finger RING 148881_at CG13059 2.2 154573_at CG8149 2.2 SAP;DNA binding;4 DNA-binding SAP 146703_at CG30158 2.2 GTP binding Ras GTPase superfamily 153520_at 5-HT7 Serotonin receptor 7 2.2 G-protein coupled serotonin receptor activity Rhodopsin-like GPCR superfamily 154930_at CG3165 3'-5' exonuclease 2.1 enzyme 154682_at Krn Keren 2.1 EGF receptor binding EGF-like domain 146238_at CG32955 2.1 kinesin;motor activity 143507_at mys integrin-beta-subunit 2.1 cell adhesion receptor 143605_at Drs Drosomycin 2.1 antifungal peptide activity Gamma thionin, Knottin 151022_at CG33188 2.1 protein binding Zn-finger AN1-like 147490_at Rgk1 GTP binding protein-like 2.1 RAS small monomeric GTPase activity Ras GTPase superfamily 148775_at CG10006 2.1 Zip;metal ion transporter activity Zinc transporter ZIP 152824_at Ect4 2.1 Sterile alpha motif SAM, ARM repeat fold, TIR Thrombospondin type I, von Willebrand factor type C, 153034_at CG32183 2.1 growth factor activity Cystine knot C-terminal 144380_at CG14770 2.1 Homeodomain-like, ARID (AT-rich interaction domain) 151685_r_at CG32813 2.1 transcription factor protein 148681_at CG12520 2.1 154808_at CG4953 2.1 Protein of unknown function DUF974, Actinoxanthin-like Peptidase S1 chymotrypsin, Apoptosis regulator Bcl-2 151834_at CG32130 2.0 BAG;protein binding protein BAG 141962_at CG5787 2.0 transcription factor; DNA binding Sodium/calcium exchanger membrane region, K+- 151600_at Nckx30C sodium/calcium exchanger 2.0 calcium potassium:sodium antiporter activity dependent Na+/Ca+ exchanger related-protein 148381_r_at CG13674 2.0 141379_at Ag5r Antigen 5-related 2.0 Allergen V5/Tpx-1 related 148130_at ida imaginal discs arrested 2.0 TPR-like 143472_at Ten-m Tenascin major 2.0 cell adhesion EGF-like domain 143221_at Gliotactin gliotactin 2.0 serine esterase 150044_at CG18213 2.0 Zn-finger MYND type 146411_at CG15145 2.0 154066_at wus wurst 2.0 chaperone Heat shock protein DnaJ N-terminal FHV specific (279 genes) Probe number Gene name Synomymus FHV * Putative function Key words 143470_at LysX Lysozyme X 6.9 lysozyme activity, cell death Glycoside hydrolase family 22 IPBinding-protein-dependent transport systems inner 141566_at CG10805 6.0 membrane component, Aldo/keto reductase, HEAT 152381_at Pcaf histone acetyltransferase 5.3 histone acetyltransferase activity Bromodomain, GCN5-related N-acetyltransferase 152230_at CG6778 4.5 glycine--tRNA ligase 155116_at POSH Plenty of SH3s 4.3 receptor signaling complex scaffold activity Zn-finger RING, Neutrophil cytosol factor 2 Leucine-rich repeat, TIR, Interleukin-1 receptor type I/Toll 152907_at 18w 18 wheeler 4.2 transmembrane receptor activity precursor 152730_at CG5205 4.2 RNA helicase activity Sec63 domain, DEAD/DEAH box helicase, AAA ATPase 149122_at CG5571 4.0 Rhodopsin-like GPCR superfamily GTP binding, hydrolase activity acting on acid Protein synthesis factor GTP-binding, Elongation factor Tu 144194_at Dgp-1 3.8 anhydrides in phosphorus-containing domain 2 anhydrides 147210_at CG12868 3.8 Tyrosine specific protein phosphatase, Rhodopsin-like 142986_at CG9311 protein phosphatase-like 3.7 protein-tyrosine-phosphatase activity GPCR superfamily 143828_at Apc APC-like 3.6 beta-catenin binding, microtubule binding Armadillo, APC cysteine-rich 145304_at psh persephone 3.6 serine-type endopeptidase activity Peptidase S1 chymotrypsin 154332_at CG12876 ALix 3.6 signal transducer activity, cell death BRO1, Rho GTPase activation protein cytidine deaminase activity, 146014_at CG8353 cytidine deaminase-like 3.6 Cytidine/deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam;zinc ion binding importin-alpha export receptor activity, cell 143953_at Cas CAS/CSE1 segregation protein 3.6 CAS/CSE C-terminal, Importin-beta N-terminal death, phagocytosis retinoid binding/fatty acid binding lipid binding, Vitellogenin_N;lipid transporter von Willebrand factor type D, Lipid transport protein N- 153828_at CG15828 3.5 protein-like glycoprotein activity terminal, Protein of unknown function DUF1081 peroxisomal carnitine O- 141776_at CG12428 3.4 carnitine O-octanoyltransferase activity Acyltransferase ChoActase/COT/CPT octanoyltransferase protein-tyrosine-phosphatase activity, Tyrosine specific protein phosphatase and dual specificity 145889_at Pez protein phosphatase-like 3.4 cytoskeletal protein binding protein phosphatase 149757_at GstD3 Glutathione S transferase D3 3.4 glutathione transferase activity Glutathione S-transferase 143031_at CG7627 ATP-binding cassette transporter 3.4 ATP-binding cassette (ABC) transporter activity ABC transporter, AAA ATPase 145025_at CG12177 purine nucleosidase 3.3 enzyme Inosine/uridine-preferring nucleoside hydrolase 149173_at CG7632 3.3 enzyme Annexin, Esterase/lipase/thioesterase 150261_at CG4335 3.3 gamma-butyrobetaine dioxygenase activity Gamma-butyrobetaine hydroxylase receptor signaling protein serine/threonine 141756_at Mekk1 heat shock construct of Inoue 3.3 kinase activity, MAP kinase kinase kinase Serine/threonine protein kinase activity 149754_at GstD10 Glutathione S transferase D10 3.3 glutathione transferase activity Glutathione S-transferase 152949_at Cyp6d4 cytochrome P450 CYP6D4 3.2 cytochrome P450 activity Cytochrome P450, E-class P450 group I 152798_at Cyp12c1 cytochrome P450 CYP12C1 3.2 cytochrome P450 activity Cytochrome P450, E-class P450 group I ATP dependent RNA helicase activity, DEAD/DEAH box helicase, ATP-dependent helicase DEAD- 153844_at Rs1 3.2 DEAD;ATP binding box 143384_at trx trithorax 3.2 DNA binding Zn-finger-like PHD finger, FY-rich domain SET-related region 141436_at CG3505 3.2 serine-type endopeptidase activity Peptidase trypsin-like serine and cysteine proteases 152481_at CG9951 3.2 motor Protein of unknown function DUF812 141381_at CG30069 3.2 RNA_pol_Rpb1_R;DNA binding Short-chain dehydrogenase/reductase SDR Pol III transcription termination factor activity, RNA-binding region RNP-1 (RNA recognition motif),
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