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!"#$% Supplemental Table II: List of genes induced by DCV, FHV and SINV
DCV specific (82 genes) Probe number Gene name Synomymus DCV * Putative function Key words 143500_at rho 12.5 signal transduction 153603_at CG10927 4.9 Unknown Cytidine/deoxycytidylate deaminase zinc-binding region 151144_at CG13553 4.2 152245_at CG13335 3.6 151473_i_at syt synaptotagmin p65 3.4 enzyme 143125_at dl dorsal 3.3 DNA binding NF-kappa-B/Rel/dorsal 150552_at CG9996 3.1 Unknown Glycosyl transferase family 8 143770_at Mtk Metchnikowin 3.0 Antifungal peptide activity
141691_at spz spatzle 3.0 Toll binding
141444_at CG2471 3.0 actin binding Leucine-rich repeat 141366_at CG10764 serine protease 3.0 serine-type endopeptidase activity Peptidase trypsin-like serine and cysteine proteases 154443_at CG1667 2.9 unknown 151661_s_at Nrt Neurotactin 2.8 cell adhesion Esterase/lipase/thioesterase
141718_at D12 2.8 transcription factor YEATS family
147495_at CG10081 2.8 Unknown Peptidase M28
143869_at vri vrille 2.8 RNA polymerase II transcription factor activity Basic-leucine zipper (bZIP) transcription factor
151648_at CalpB Calpain-B 2.7 calpain activity Peptidase C2 calpain 152979_at CG31531 2.7
152405_at CG6014 2.7 Unknown C-type lectin
147951_at CG13905 2.7
154983_at CG15634 2.7 AICARFT/IMPCHase bienzyme, Methylglyoxal synthase-like 153761_at CG11089 2.6 Unknown domain
141974_at CG4573 2.6 tyrosine--tRNA ligase; enzyme
153004_at CG8603 2.6 motor
153432_at Thor Thor 2.6 Eukaryotic initiation factor 4E binding Eukaryotic translation initiation factor 4E binding
142200_at CG32477 2.5
151361_at RhoGAP18B 2.5 GTPase activator activity Rho GTPase activation protein
148533_at ninjurin A ninjurin 2.5 cell adhesion 142429_at CG14089 2.5 Collagen triple helix repeat 142097_at Myosin 31DF myosin I 2.5 Actin binding Myosin head (motor domain), IQ calmodulin-binding region
154415_at CG3279 2.5 v-SNARE activity Vesicle transport v-SNARE
Fibronectin type III, Immunoglobulin-like, Peptidase M14 143665_at fra frazzled 2.5 netrin receptor activity carboxypeptidase A
153174_at CG9925 2.5 Maternal tudor protein, Zn-finger MYND type
151557_i_at CG32737 2.5 144197_at rdgB 2.5 phosphatidylinositol transporter activity Phosphatidylinositol transfer protein 147151_at CG18279 2.4 155065_at hdc headcase 2.3 signal transduction 151217_at U snoRNA host gene 1 2.3 151871_at CG30494 2.3 ligand binding or carrier
Zn-finger C2H2 type, Cytochrome c heme-binding site, 144505_at CG32767 2.3 Nucleic acid binding Immunoglobulin/MHC
152889_at dei delilah 2.3 transcription factor activity Basic helix-loop-helix dimerization domain bHLH Eukaryotic protein of unknown function DUF292, Pancreatic 153798_at CG10103 2.3 transcription factor ribonuclease General substrate transporter, Sugar transporter 154436_at rtet tetracycline resistance 2.3 sugar porter activity superfamily 147575_at CG18413 2.3 1-phosphatidylinositol-45- 1-phosphatidylinositol-45-biphosphate 142250_at norpA 2.3 biphosphate phosphodiesterase phosphodiesterase ; EC:3.1.4.11 153304_at bip1 2.2
145526_at CG4213 2.2 motor
148109_at CG12014 2.2 iduronate-2-sulfatase activity Sulfatase 153934_at CG12190 2.2 transcription factor Zn-finger Ran-binding 153814_at CG17612 2.2 nucleic acid binding Zn-finger C2H2 type
143293_at pbl pebble 2.2 guanyl-nucleotide exchange factor activity Rhodopsin-like GPCR superfamily
Dynein heavy chain, Peptidase eukaryotic cysteine 143726_at Dhc93AB Dynein heavy chain at 93AB 2.2 Dynein_heavy;microtubule motor activity peptidase active site, AAA ATPase 155084_at CG17260 2.2 nucleic acid binding Zn-finger RING
148881_at CG13059 2.2
154573_at CG8149 2.2 SAP;DNA binding;4 DNA-binding SAP 146703_at CG30158 2.2 GTP binding Ras GTPase superfamily
153520_at 5-HT7 Serotonin receptor 7 2.2 G-protein coupled serotonin receptor activity Rhodopsin-like GPCR superfamily
154930_at CG3165 3'-5' exonuclease 2.1 enzyme
154682_at Krn Keren 2.1 EGF receptor binding EGF-like domain
146238_at CG32955 2.1 kinesin;motor activity 143507_at mys integrin-beta-subunit 2.1 cell adhesion receptor 143605_at Drs Drosomycin 2.1 antifungal peptide activity Gamma thionin, Knottin
151022_at CG33188 2.1 protein binding Zn-finger AN1-like
147490_at Rgk1 GTP binding protein-like 2.1 RAS small monomeric GTPase activity Ras GTPase superfamily
148775_at CG10006 2.1 Zip;metal ion transporter activity Zinc transporter ZIP 152824_at Ect4 2.1 Sterile alpha motif SAM, ARM repeat fold, TIR Thrombospondin type I, von Willebrand factor type C, 153034_at CG32183 2.1 growth factor activity Cystine knot C-terminal
144380_at CG14770 2.1
Homeodomain-like, ARID (AT-rich interaction domain) 151685_r_at CG32813 2.1 transcription factor protein
148681_at CG12520 2.1
154808_at CG4953 2.1 Protein of unknown function DUF974, Actinoxanthin-like
Peptidase S1 chymotrypsin, Apoptosis regulator Bcl-2 151834_at CG32130 2.0 BAG;protein binding protein BAG 141962_at CG5787 2.0 transcription factor; DNA binding Sodium/calcium exchanger membrane region, K+- 151600_at Nckx30C sodium/calcium exchanger 2.0 calcium potassium:sodium antiporter activity dependent Na+/Ca+ exchanger related-protein 148381_r_at CG13674 2.0
141379_at Ag5r Antigen 5-related 2.0 Allergen V5/Tpx-1 related
148130_at ida imaginal discs arrested 2.0 TPR-like
143472_at Ten-m Tenascin major 2.0 cell adhesion EGF-like domain 143221_at Gliotactin gliotactin 2.0 serine esterase 150044_at CG18213 2.0 Zn-finger MYND type
146411_at CG15145 2.0
154066_at wus wurst 2.0 chaperone Heat shock protein DnaJ N-terminal FHV specific (279 genes)
Probe number Gene name Synomymus FHV * Putative function Key words
143470_at LysX Lysozyme X 6.9 lysozyme activity, cell death Glycoside hydrolase family 22
IPBinding-protein-dependent transport systems inner 141566_at CG10805 6.0 membrane component, Aldo/keto reductase, HEAT 152381_at Pcaf histone acetyltransferase 5.3 histone acetyltransferase activity Bromodomain, GCN5-related N-acetyltransferase
152230_at CG6778 4.5 glycine--tRNA ligase
155116_at POSH Plenty of SH3s 4.3 receptor signaling complex scaffold activity Zn-finger RING, Neutrophil cytosol factor 2
Leucine-rich repeat, TIR, Interleukin-1 receptor type I/Toll 152907_at 18w 18 wheeler 4.2 transmembrane receptor activity precursor
152730_at CG5205 4.2 RNA helicase activity Sec63 domain, DEAD/DEAH box helicase, AAA ATPase
149122_at CG5571 4.0 Rhodopsin-like GPCR superfamily GTP binding, hydrolase activity acting on acid Protein synthesis factor GTP-binding, Elongation factor Tu 144194_at Dgp-1 3.8 anhydrides in phosphorus-containing domain 2 anhydrides 147210_at CG12868 3.8
Tyrosine specific protein phosphatase, Rhodopsin-like 142986_at CG9311 protein phosphatase-like 3.7 protein-tyrosine-phosphatase activity GPCR superfamily
143828_at Apc APC-like 3.6 beta-catenin binding, microtubule binding Armadillo, APC cysteine-rich
145304_at psh persephone 3.6 serine-type endopeptidase activity Peptidase S1 chymotrypsin
154332_at CG12876 ALix 3.6 signal transducer activity, cell death BRO1, Rho GTPase activation protein
cytidine deaminase activity, 146014_at CG8353 cytidine deaminase-like 3.6 Cytidine/deoxycytidylate deaminase zinc-binding region dCMP_cyt_deam;zinc ion binding importin-alpha export receptor activity, cell 143953_at Cas CAS/CSE1 segregation protein 3.6 CAS/CSE C-terminal, Importin-beta N-terminal death, phagocytosis retinoid binding/fatty acid binding lipid binding, Vitellogenin_N;lipid transporter von Willebrand factor type D, Lipid transport protein N- 153828_at CG15828 3.5 protein-like glycoprotein activity terminal, Protein of unknown function DUF1081 peroxisomal carnitine O- 141776_at CG12428 3.4 carnitine O-octanoyltransferase activity Acyltransferase ChoActase/COT/CPT octanoyltransferase protein-tyrosine-phosphatase activity, Tyrosine specific protein phosphatase and dual specificity 145889_at Pez protein phosphatase-like 3.4 cytoskeletal protein binding protein phosphatase 149757_at GstD3 Glutathione S transferase D3 3.4 glutathione transferase activity Glutathione S-transferase
143031_at CG7627 ATP-binding cassette transporter 3.4 ATP-binding cassette (ABC) transporter activity ABC transporter, AAA ATPase
145025_at CG12177 purine nucleosidase 3.3 enzyme Inosine/uridine-preferring nucleoside hydrolase
149173_at CG7632 3.3 enzyme Annexin, Esterase/lipase/thioesterase
150261_at CG4335 3.3 gamma-butyrobetaine dioxygenase activity Gamma-butyrobetaine hydroxylase
receptor signaling protein serine/threonine 141756_at Mekk1 heat shock construct of Inoue 3.3 kinase activity, MAP kinase kinase kinase Serine/threonine protein kinase activity
149754_at GstD10 Glutathione S transferase D10 3.3 glutathione transferase activity Glutathione S-transferase
152949_at Cyp6d4 cytochrome P450 CYP6D4 3.2 cytochrome P450 activity Cytochrome P450, E-class P450 group I
152798_at Cyp12c1 cytochrome P450 CYP12C1 3.2 cytochrome P450 activity Cytochrome P450, E-class P450 group I
ATP dependent RNA helicase activity, DEAD/DEAH box helicase, ATP-dependent helicase DEAD- 153844_at Rs1 3.2 DEAD;ATP binding box
143384_at trx trithorax 3.2 DNA binding Zn-finger-like PHD finger, FY-rich domain SET-related region
141436_at CG3505 3.2 serine-type endopeptidase activity Peptidase trypsin-like serine and cysteine proteases
152481_at CG9951 3.2 motor Protein of unknown function DUF812
141381_at CG30069 3.2 RNA_pol_Rpb1_R;DNA binding Short-chain dehydrogenase/reductase SDR
Pol III transcription termination factor activity, RNA-binding region RNP-1 (RNA recognition motif), RNA- 143668_at La La autoantigen-like 3.2 RNA binding, 5S rRNA primary transcript binding protein Lupus Lal binding
153930_at CG5224 3.1 glutathione transferase activity Glutathione S-transferase
143374_at T-cp1 Tcp1-like 3.1 chaperone activity, phagocytosis Chaperonin Cpn60/TCP-1, GroEL-like chaperone ATPase
153051_at CG4841 3.1
143696_at CG4038 3.0 Gar1 protein RNA-binding region
141466_at CG15099 3.0 protein kinase Dopey N-terminal
154265_at CG8258 T-complex protein 1 theta-subunit 3.0 chaperonin ATPase activity Chaperonin Cpn60/TCP-1, GroEL-like chaperone ATPase Cyclin-like F-box, Zn-finger CXXC type, Cytochrome c heme- 151745_at CG11033 3.0 binding site, Leucine-rich repeat cysteine-containing subtype, Transcription factor jumonji jmjC
152411_at CG10286 3.0 ARM repeat fold
DEAD/DEAH box helicase, Heavy metal 146573_at CG9253 3.0 ATP dependent RNA helicase activity transport/detoxification protein
152638_at CG3363 2.9 DNA binding
154861_at asf1 anti-silencing factor 1 2.9 cell cycle regulator Anti-silencing protein ASF1-like, p53-like transcription factor
SNF2 related domain, DEAD/DEAH box helicase, ARM repeat 152420_at Hel89B Helicase 89B 2.9 ATP dependent DNA helicase activity fold UBA/THIF-type NAD/FAD binding fold, Ubiquitin-activating 152946_at Uba1 Ubiquitin activating enzyme 1 2.9 ubiquitin activating enzyme activity enzyme repeat 151728_at CG18596 2.9 SpoU_methylase;RNA binding tRNA/rRNA methyltransferase (SpoU), ARM repeat fold damaged DNA binding, CPSF_A;nucleic acid CPSF A subunit C-terminal, Immunoglobulin/major 147940_at CG13900 spliceosomal protein-like 2.9 binding histocompatibility complex actin binding, structural constituent of 154742_at Arp66B Actin-related protein 66B 2.8 Actin/actin-like, phagocytosis cytoskeleton Aminoacyl-tRNA synthetase class Ia, Valyl-tRNA synthetase 141603_at Aats-val Valyl-tRNA synthetase 2.8 glutamate-tRNA ligase activity class Ia
Zn-finger MYND type, Programmed cell death protein 2 C- 147841_at Zfrp8 Zinc finger protein RP-8 2.8 DNA binding terminal, 4Fe-4S ferredoxin iron-sulfur binding domain peripheral-type benzodiazepine 151838_at CG2789 2.8 benzodiazepine receptor activity TspO/MBR-related protein receptor
154028_at CG9200 2.8 myb_DNA-binding;DNA binding Myb DNA-binding domain, Homeodomain-like
154859_at CG17904 2.8 nucleotide binding
Alpha-2-macroglobulin, Terpenoid cylases/protein 152023_at TepIII Thiolester containing protein III 2.8 endopeptidase inhibitor activity, phagocytosis prenyltransferase alpha-alpha toroid
146827_at CG8738 2.8 serine-type endopeptidase activity Peptidase trypsin-like serine and cysteine proteases
150418_at sav salvador 2.8 enzyme, cell death WW/Rsp5/WWP domain
153299_at CG12292 2.8 Protein of unknown function DUF803
152623_at Est2 Esterase-2 2.7 carboxylesterase activity Carboxylesterase type B, Esterase/lipase/thioesterase
154156_at CG5033 2.7 transcription factor activity G-protein beta WD-40 repeat aldehyde reductase activity, trans-12- 148662_at CG10638 aldehyde reductase-like 2.7 Aldo/keto reductase dihydrobenzene-12-diol dehydrogenase activity
154452_at c11.1 2.7 ARM repeat fold
carnitine-acylcarnitine carrier carrier activity, acyl carnitine transporter Mitochondrial substrate carrier, Mitochondrial carrier 154670_at CG3476 2.7 protein activity protein, Adenine nucleotide translocator 1
transcription factor activity, ligand-dependent Zn-finger C4-type steroid receptor, Vitamin D receptor, 143144_at eg eagle 2.7 nuclear receptor activity Steroid nuclear receptor ligand-binding
154451_at CG2691 2.7 ARM repeat fold
143782_at Cyp4p1 Cytochrome P450-4p1 2.7 cytochrome P450 activity Cytochrome P450, E-class P450 group I
tRNA synthetase class II (D K and N), OB-fold nucleic acid 153336_at Aats-asp Aspartyl-tRNA synthetase 2.7 aspartate-tRNA ligase activity binding domain, Aspartyl-tRNA synthetase archea/euk type CUB, EGF-like domain, Aspartic acid and asparagine 141481_at CG32702 2.7 metalloendopeptidase activity hydroxylation site
type-I transmembrane ER-resident protein kinase activity, eukaryotic elongation 149333_at PEK 2.7 Serine/threonine protein kinase, Bacterial quinoprotein serine/threonine kinase-like factor-2 kinase activity
antibacterial peptide activity, wide-spectrum Alpha-2-macroglobulin, Serpin, Terpenoid cylases/protein 145970_at TepII Thiolester containing protein II 2.7 protease inhibitor activity, phagocytosis prenyltransferase alpha-alpha toroid endothelin-converting enzyme activity, 142141_at CG4723 2.7 Peptidase M13 neprilysin Peptidase_M13_N;metallopeptidase activity
141207_at CG4453 nucleoporin 2.7 endopeptidase
protein carrier activity, RAN protein binding, 151799_at msk moleskin 2.6 Importin-beta N-terminal, ARM repeat fold protein transporter activity 144700_at CG15347 2.6 Protein of unknown function DUF753
146788_at CG11210 2.6 Protein of unknown function DUF221
149968_at CG5399 2.6
154083_at Smg5 2.6 Nucleotide binding protein PINc
sphingomyelin phosphodiesterase activator Beige/BEACH domain, G-protein beta WD-40 repeat, 152479_at CG6734 2.6 activity Immunoglobulin/MHC 142720_at CG11660 2.6 protein kinase activity Protein of unknown function RIO1, Tyrosine protein kinase
142550_at l(3)mbt lethal (3) malignant brain tumor 2.6 transcription factor activity Sterile alpha motif (SAM)/Pointed domain, Mbt repeat
145098_at Lsd-2 Lipid storage droplet-2 2.6 Perilipin
RAB-protein geranylgeranyltransferase activity, 154565_at CG12007 2.6 Protein prenyltransferase PPTA;protein prenyltransferase activity 145074_at CG5321 2.6 gamma-butyrobetaine dioxygenase activity Gamma-butyrobetaine hydroxylase Interferon-related protein conserved region, Ankyrin, ARM 145681_at CG31694 interferon-like 2.6 signal transduction repeat fold
153088_at pst pastrel 2.6
antibacterial peptide activity, endopeptidase 146503_at TepIV Thiolester containing protein IV 2.6 Alpha-2-macroglobulin, HPr serine phosphorylation site inhibitor activity
154692_at CG18240 2.6 Cytochrome P450, E-class P450 group I
GTP binding, GTP_EFTU;translation elongation Protein synthesis factor GTP-binding, Elongation factor Tu 141564_at CG2017 2.6 factor activity domain 2 latrotoxin receptor activity, Gal_Lectin;sugar D-galactoside/L-rhamnose binding SUEL lectin domain, G- 146823_at Cirl latrophilin receptor-like 2.6 binding protein coupled receptor family 2 (secretin-like) glucuronosyltransferase activity, 147690_at Ugt58Fa 2.6 UDPGT;transferase activity transferring hexosyl UDP-glucoronosyl/UDP-glucosyl transferase groups Pre-mRNA processing ribonucleoprotein binding region, 153330_at Nop56 2.6 Nucleic acid-binding OB-fold
154194_at CG8939 2.5 rRNA methyltransferase activity Ribosomal RNA methyltransferase RrmJ/FtsJ
Pancreatic trypsin inhibitor (Kunitz), Immunoglobulin-like, 142182_s_at Ppn Papilin 2.5 Thrombospondin type I, EGF-like domain
electron carrier activity, fer2;electron 143690_at Fdxh Ferredoxin 2.5 Ferredoxin, Adrenodoxin, Cytochrome c heme-binding site transporter activity
[acyl-carrier protein] S-acetyltransferase Zinc-containing alcohol dehydrogenase superfamily, 151887_at v(2)k05816 2.5 activity, enoyl-[acyl-carrier protein] reductase Thioesterase, Phosphopantetheine-binding domain, Acyl (NADPH B-specific) activity transferase domain
154537_at CG31738 2.5 cell adhesion Fibronectin type III, Ribosomal protein S2
144074_at CG4025 2.5
148524_at CG14152 2.5 149907_r_at CG8066 cystatin-like 2.5 cysteine protease inhibitor activity Sarcocystatin, Cysteine protease inhibitor 154829_at CG7728 2.5 Protein of unknown function DUF663 oxidoreductase activity acting on CH-OH group Short-chain dehydrogenase/reductase SDR, Glucose/ribitol 149345_at CG12171 alcohol dehydrogenase-like 2.5 of donors, adh_short;oxidoreductase activity dehydrogenase 152727_at CG7224 2.5 153358_at Nmd3 Nonsense-mediated mRNA 3 2.5 RNA binding, protein binding NMD3 family, Cytochrome c heme-binding site
153152_at CG11920 2.5 Brix domain
alpha-tocopherol transfer protein- 154616_at CG31633 2.5 ligand binding or carrier Cyclin-like F-box, Four-helical cytokine like 154916_at CG7417 2.5 transcription factor activity Ubiquitin system component Cue, Zn-finger Ran-binding
145612_at CG7291 2.5 signal transduction E1 protein and Def2/Der2 allergen
141658_at CG5853 ATP-binding cassette transporter 2.5 ATP-binding cassette (ABC) transporter activity Phagocytosis, Phosphopantetheine attachment site
142836_at CG32041 heat shock protein 22 kD 2.5 heat shock protein
146844_at CG30349 2.5 G-protein beta WD-40 repeat
143606_at Cyp18a1 Cytochrome P450-18a1 2.5 cytochrome P450 activity Cytochrome P450, E-class P450 group I guanine deaminase activity, 155054_at CG18143 2.5 Amidohydrolase, Calcium-binding EF-hand Amidohydro_1;hydrolase activity Zn-finger C2H2 type, Zinc-finger protein of unknown 152398_at CG10631 2.5 nucleic acid binding function DM3 154928_at wdn wings down 2.4 RNA polymerase II transcription factor activity Zn-finger C2H2 type
145309_at CG6335 histidine--tRNA ligase 2.4 enzyme
tRNA synthetases class-II (G H P and S), Aminoacyl-transfer 142167_at CG17259 serine--tRNA ligase-like 2.4 serine-tRNA ligase activity RNA synthetase class II 145230_at CG5010 2.4 CHCH transcription factor activity, myb_DNA- 142244_at CG9305 2.4 Myb DNA-binding domain binding;DNA binding 153052_at CG10420 2.4 ARM repeat fold
154647_at CG8877 2.4 pre-mRNA splicing factor activity Peptidase M67 Mov34
glucose transporter activity, General substrate transporter, Sugar transporter 143040_at CG4797 sugar transporter-like 2.4 sugar_tr;transporter activity superfamily
142263_at CG32836 2.4 ligand binding or carrier
helicase activity, DNA dependent ATPase SNF2 related domain, DNA topoisomerase II, ATP-dependent 151511_r_at dom domino 2.4 activity, general RNA polymerase II DNA ligase transcription factor activity
153862_at l(3)07882 2.4 Nop14-like protein
RAB-protein geranylgeranyltransferase activity, 153458_at Rep Rab escort protein 2.4 Rab GTPase activator Rab escort protein activity
G-protein beta WD-40 repeat, Lissencephaly type-1-like 141309_at CG7611 2.4 chaperone homology motif
polypeptide N- polypeptide N-acetylgalactosaminyltransferase 152222_at CG4445 2.4 Glycosyl transferase family 2, Ricin B lectin domain acetylgalactosaminyltransferase activity
146718_at Tsp42Er Tetraspanin 42Er 2.4 CD9/CD37/CD63 antigen, Tetraspanin protein serine/threonine phosphatase activity, Serine/threonine-specific protein phosphatase and bis(5- 143976_at Pp4-19C Protein phosphatase 19C 2.4 CTD phosphatase activity, nucleosyl)-tetraphosphatase Metallophos;hydrolase activity Carboxylesterase type B, TONB Box N terminus, 154994_at clt cricklet 2.3 carboxylesterase activity Esterase/lipase/thioesterase
145265_at CG6762 2.3 ParB-like nuclease
154620_at CG6181 2.3 motor G-protein beta WD-40 repeat
151373_at CG32795 2.3
147699_at CG4250 2.3 EGF-like domain
152100_at CG31705 2.3 DNA binding
153963_at CG16971 2.3
153320_at Smg6 2.3 RNA binding Nucleotide binding protein PINc, TPR-like
RAB small monomeric GTPase activity, GTP Ras GTPase superfamily, ARF/SAR superfamily, Sigma-54 152357_at Rab-RP4 Rab-related protein 4 2.3 binding, ras;small monomeric GTPase activity factor interaction domain ATP dependent RNA helicase activity, KH, DEAD/DEAH box helicase, ATP-dependent helicase 154657_at CG7878 2.3 KH;nucleic acid binding DEAD-box
143627_at cora coracle 2.3 cytoskeletal protein binding Band 4.1, Ezrin/radixin/moesin ERM, FERM
Lethal(2) giant larvae protein, Regulator of chromosome 153565_at l(2)gl lethal (2) giant larvae 2.3 myosin II binding, cell death condensation RCC1 taste receptor activity, G-protein coupled 144536_at Tre1 heat shock construct of Ishimoto 2.3 Rhodopsin-like GPCR superfamily receptor activity unknown ligand, cell death DNA binding, RNA binding, rrm;nucleic acid 154081_at mod modulo 2.3 RNA-binding region RNP-1 (RNA recognition motif) binding
Octicosapeptide/Phox/Bem1p, Zn-finger ZZ type, Peptidase 152056_at ref(2)P refractory to sigma P 2.3 eukaryotic cysteine peptidase, Ubiquitin-associated domain
153126_at CG11523 2.3
SNF;neurotransmitter:sodium symporter 145975_at CG13795 2.3 Sodium:neurotransmitter symporter activity
152368_at CG8913 2.3 peroxidase activity Animal haem peroxidase, Haem peroxidase
142736_s_at Hmgs HMG Coenzyme A synthase 2.3 hydroxymethylglutaryl-CoA synthase activity Hydroxymethylglutaryl-coenzyme A synthase
154193_at Set 2.3 cyclin binding, NAP;DNA binding Nucleosome assembly protein (NAP)
149558_at CG16777 2.3
galactose-specific C-type lectin- 146490_at CG9978 2.3 lectin_c;sugar binding C-type lectin like 147547_at CG18067 2.3 3'5'-cyclic nucleotide phosphodiesterase
Protein of unknown function DUF139, EGF-like domain, 142395_at CG31839 nimrodB2 2.3 cell adhesion Growth factor receptor 151642_at stich1 sticky ch1 2.3 Basic helix-loop-helix dimerization domain bHLH 141751_at east enhanced adult sensory threshold 2.3 Peptidase M14 carboxypeptidase A
144771_at CG9691 2.3
150295_at CG7044 2.3 ARM repeat fold
uridine phosphorylase activity, Purine and other phosphorylases family 1, Uridine 145684_at CG17224 2.3 PNP_UDP_1;catalytic activity phosphorylase eukaryotic
152444_at ken ken and barbie 2.3 transcription factor activity, phagocytosis Zn-finger C2H2 type, BTB/POZ domain, Immunoglobulin-like
methylenetetrahydrofolate methylenetetrahydrofolate reductase (NADPH) 148573_at CG7560 2.3 Methylenetetrahydrofolate reductase reductase activity 151946_at Os9 Olfactory-specific 9 2.3 pheromone binding
152518_at CG8231 T-complex protein 1 zeta-subunit 2.3 chaperonin ATPase activity Chaperonin Cpn60/TCP-1, GroEL-like chaperone ATPase
translation initiation factor activity, MIF4G;RNA eIF4-gamma/eIF5/eIF2-epsilon, Initiation factor eIF-4 gamma 152430_at l(2)01424 NAT1 2.3 binding, cell death middle, ARM repeat fold
152280_at CG2467 2.3 Endoglin/CD105 antigen
Serine palmitoyltransferase 147131_at Spt-I 2.2 serine C-palmitoyltransferase activity subunit I
149759_at GstD5 Glutathione S transferase D5 2.2 glutathione transferase activity Glutathione S-transferase
152817_at CG1648 2.2
specific RNA polymerase II transcription factor 153515_at Dr Drop 2.2 Homeobox, Homeodomain-like activity
144950_at CG32654 glutamate receptor-like 2.2 enzyme
149937_at CG6912 2.2
translation release factor activity, Elongation factor Tu, Translation factor, Protein synthesis 142364_at HBS1 translation initiation factor 3-like 2.2 GTP_EFTU;translation elongation factor activity factor GTP-binding
Pheromone-binding protein- pheromone binding, phenylalkylamine binding, Pheromone/general odorant binding protein PBP/GOBP, 143646_at Pbprp1 2.2 related protein 1 PBP_GOBP;odorant binding Insect pheromone/odorant binding protein PhBP CBF/Mak21 family, Peptidase eukaryotic cysteine peptidase, 154719_at CG1234 2.2 ARM repeat fold 146710_at Tsp42Ef Tetraspanin 42Ef 2.2 CD9/CD37/CD63 antigen, Tetraspanin
144142_at Kaz1 2.2 serine protease inhibitor
154940_at CG6876 2.2 pre-mRNA splicing factor activity Pre-mRNA processing ribonucleoprotein binding region
146453_at CG31753 2.2 nucleic acid binding
BRK, SNF2 related domain, Helicase, Chromo, DEAD/DEAH 141644_at kis kismet 2.2 DNA helicase activity box helicase 147097_at CG30044 2.2 serine-type endopeptidase activity, 143699_at Ser6 Serine protease 6 2.2 Peptidase trypsin-like serine and cysteine proteases trypsin;trypsin activity
152874_at CG30015 2.2 motor
144115_at cib ciboulot 2.2 actin binding Thymosin beta-4
144890_at CG15220 replication factor A 14 kD subunit 2.2 DNA binding Nucleic acid-binding OB-fold
149419_at CG1105 2.2 Arrestin
146699_at Spn4 Serine protease inhibitor 4 2.2 serine-type endopeptidase inhibitor activity Serpin, Endoplasmic reticulum targeting sequence
142349_at yellow-f yellow-f 2.2 intramolecular isomerase activity Major royal jelly protein
149057_at CG9295 cuticle protein 2.2 structural constituent of cuticle (sensu Insecta) Insect cuticle protein
154058_at CG5295 2.2 Patatin;catalytic activity Patatin
142674_at CG8282 sorting nexin-like 2.2 Phox-like
154433_at CG7338 2.2 Protein of unknown function DUF663 Filamin/ABP280 repeat, Calponin-like actin-binding, Actin- 151902_at jbug jitterbug 2.2 actin binding binding actinin-type Ribosomal_L7Ae;structural constituent of Ribosomal protein L7Ae/L30e/S12e/Gadd45, High mobility 142579_at NHP2 2.2 ribosome group-like nuclear protein
141491_at CG8465 2.2 enzyme inhibitor Ankyrin, Ribosomal protein L9 N-terminal-like
C2 domain, Pleckstrin-like, Ras GTPase-activating protein, 143456_at Gap1 GTPase-activating protein 1 2.2 Ras GTPase activator activity Rho GTPase activation protein 154505_at CG9107 2.2 rrm;nucleic acid binding RNA-binding region RNP-1 (RNA recognition motif)
154039_at CG11738 2.2 RNA binding KH
141457_at Mtor Megator 2.2 motor
141622_at CG5841 ankyrin-like 2.1 apoptosis inhibitor Ankyrin, Zn-finger ZZ type, Mib_herc2, Zn-finger RING glycine dehydrogenase (decarboxylating) 149624_at CG3999 glycine dehydrogenase p protein 2.1 Glycine cleavage system P-protein activity cystathionine beta-synthase activity, Cysteine synthase/cystathionine beta-synthase P- 154013_at CG1753 cystathionine beta-synthase-like 2.1 PALP;lyase activity phosphate-binding site, Cystathionine beta-synthase Aminotransferase class I and II, Aminolevulinic acid 141461_at Alas Aminolevulinate synthase 2.1 5-aminolevulinate synthase activity synthase endonuclease G activity, Endonuclease;nucleic 154735_at CG8862 2.1 DNA/RNA non-specific endonuclease acid binding 155000_at CG7806 ATP-binding cassette transporter 2.1 ion channel
149590_at CG8516 2.1
150379_at CG6937 RNA binding protein-like 2.1 RNA binding, rrm;nucleic acid binding RNA-binding region RNP-1 (RNA recognition motif)
cathepsin L activity, KRAB;nucleic acid binding, Peptidase C1A papain, KRAB box, Peptidase eukaryotic 141762_at Cp1 Cysteine proteinase-1 2.1 Cell death cysteine peptidase active site
151904_at CG31012 2.1 SH3/SH2 adaptor protein activity SH3, Neutrophil cytosol factor 2
155134_at MICAL-like alpha-actinin-like 2.1 actin binding Zn-binding protein LIM, Calponin-like actin-binding
AAA ATPase VAT, Cell division protein 48 CDC48 domain 2, 143738_at Nsf2 NEM-sensitive fusion protein 2 2.1 cdc48_N;ATP binding Aspartate decarboxylase-like fold 143000_at CG5525 2.1 chaperonin ATPase activity Chaperonin Cpn60/TCP-1, GroEL-like chaperone ATPase
144243_at Spn6 Serine protease inhibitor 6 2.1 serine-type endopeptidase inhibitor activity Serpin SNF4/AMP-activated protein protein serine/threonine kinase activity, 154116_at SNF4A 2.1 CBS domain kinase gamma subunit SNF1A/AMP-activated protein kinase activity
149138_at CG4858 2.1 nucleotide binding Mrp family
estradiol 17 beta-dehydrogenase- steroid dehydrogenase activity, Short-chain dehydrogenase/reductase SDR, Glucose/ribitol 146386_at CG13284 2.1 like adh_short;oxidoreductase activity dehydrogenase, phagocytosis 145647_at Cyp309a1 cytochrome P450 CYP309A1 2.1 cytochrome P450 activity Cytochrome P450, E-class P450 group I
147354_at CG15917 2.1
152511_at Ela Elastin-like 2.1 Collagen triple helix repeat
142566_at CG2926 2.1 PHD;DNA binding Zn-finger RING, Zn-finger-like PHD finger
152581_at Spn5 Serine protease inhibitor 5 2.1 serine-type endopeptidase inhibitor activity Serpin
152470_at CG10189 2.1
152019_at to takeout 2.1 Odorant binding protein 155057_at CG10107 2.1 cysteine-type peptidase activity Peptidase C48 SUMO/Sentrin/Ubl1 153909_at CG2972 2.1 Protein of unknown function DUF133 149260_s_at CG10712 2.1 DNA binding 145393_at CG32528 2.1 actin binding Calponin-like actin-binding 145547_r_at CG13947 2.1
152066_at BcDNA:GH06451 asparagine--tRNA ligase-like 2.1 enzyme
144015_at Smrter Smr 2.1 transcription co-repressor, phagocytosis ecdysone receptor co-repressor Rabex-5, guanyl-nucleotide guanyl-nucleotide exchange factor activity, zf- 141553_at CG9139 2.1 Zn-finger A20-like, Vacuolar sorting protein 9 exchange factor A20;DNA binding 149020_at CG6843 CBF1 interacting corepressor 2.1 transcription factor binding ubiquitin-specific protease activity, Peptidase C19 ubiquitin carboxyl-terminal hydrolase family 154133_at CG15817 2.1 UCH;cysteine-type endopeptidase activity 2 Laminin-type EGF-like domain, Galactose-binding like, 154252_at LanA Laminin A 2.1 structural protein Concanavalin A-like lectin/glucanase
145466_at CG32521 2.1
150514_at CG13618 2.1 Odorant binding protein
thiol-disulfide exchange intermediate activity, 141539_at Trx-2 thioredoxin-2 2.1 Thioredoxin type domain, Thioredoxin domain 2 thiored;electron transporter activity
152780_at CG7967 2.1 Protein of unknown function DUF605
147696_at CG13510 2.1
peptidoglycan recognition protein- N-acetylmuramoyl-L-alanine amidase family 2, Animal 142657_at PGRP-SB1 2.1 peptidoglycan recognition activity like peptidoglycan recognition protein PGRP tRNA binding, translation initiation factor 142531_at eIF-2 Eukaryotic initiation factor 2&bgr; 2.1 Translation initiation factor IF5 activity, GTP binding Saccharomyces cerevisiae UAS 144174_at inx2 2.1 innexin channel activity Innexin construct a of Stebbings
150746_at CG12883 2.1
143957_at CG11971 2.1 nucleic acid binding Zn-finger C2H2 type
143982_at Chd3 DEAH-box helicase 2.1 ATP dependent DNA helicase ; EC:3.6.1.3
154495_at CG6459 2.1 defense/immunity protein Mitochondrial glycoprotein
143058_f_at Act5C Actin 5C 2.1 structural constituent of cytoskeleton Actin/actin-like, phagocytosis
Deoxyribonuclease/rho motif-related TRAM, Radical SAM, 153079_at CG6550 2.1 MiaB-like tRNA modifying enzyme archaeal-type 144369_at CG11378 2.1 Protein of unknown function DUF1397
146611_at CG6448 2.1 receptor
ubiquitin-protein ligase activity, apoptosis Zn-finger RING, Baculovirus inhibitor of apoptosis protein 152631_at th thread 2.1 inhibitor activity repeat (BIR) Pheromone/general odorant binding protein PBP/GOBP, 150834_at Obp99c Odorant-binding protein 99c 2.1 PBP_GOBP;odorant binding Insect pheromone/odorant binding protein PhBP
154669_at CG5080 2.1 motor alpha-tocopherol transfer protein- Cellular retinaldehyde-binding)/triple function, alpha- 146898_at CG12926 2.1 tocopherol binding like tocopherol transport transcription factor activity, RNA polymerase II Paired amphipathic helix, H+-transporting two-sector 141716_at Sin3A 2.0 transcription factor activity ATPase
143784_at Fer2LCH Ferritin 2 light chain homologue 2.0 ferrous iron binding, ferritin;binding Ferritin/ribonucleotide reductase-like AAA ATPase central region, MIT, Viral coat and capsid 154205_at spas spastin 2.0 ATPase activity protein 152140_at CG8678 2.0 enzyme G-protein beta WD-40 repeat
146771_at CG1882 2.0 enzyme Alpha/beta hydrolase fold, Esterase/lipase/thioesterase
149251_at l(3)04053 2.0
147486_i_at CG18606 2.0
142778_at bcn92 2.0 Complex 1 LYR protein
high affinity inorganic phosphate:sodium 142212_at l(2)08717 sodium/phosphate cotransporter 2.0 General substrate transporter, Major facilitator superfamily symporter activity, sugar_tr;transporter activity [2Fe-2S]-binding, Ferredoxin, 2Fe-2S ferredoxin iron-sulfur 154786_at CG18522 2.0 fer2;electron transporter activity binding site 147364_at CG14478 2.0 C-5 cytosine-specific DNA methylase
150582_at CG13659 2.0 Protein of unknown function DUF227
serine-type endopeptidase activity, 148144_at CG14990 2.0 Peptidase trypsin-like serine and cysteine proteases trypsin;trypsin activity
154757_at CG14991 mitogen inducible protein-like 2.0 Pleckstrin-like /// IPR009065 // FERM 2OG-Fe(II) oxygenase superfamily, Prolyl 4-hydroxylase 154136_at CG31120 2.0 alpha subunit 146493_at CG9987 2.0 Protein of unknown function UPF0027
Filamin/ABP280 repeat, Calponin-like actin-binding, Actin- 141641_at cher cheerio 2.0 actin binding binding actinin-type
143020_at Talin talin 2.0 actin binding, cytoskeletal anchoring activity
Short-chain dehydrogenase/reductase SDR, Glucose/ribitol 155055_at CG31549 2.0 oxidoreductase activity dehydrogenase
145021_at ligase4 DNA ligase 2.0 DNA ligase (ATP) activity ATP-dependent DNA ligase, BRCT
151208_at CG15068 2.0
PDZ/DHR/GLGF domain, Phosphotyrosine interaction 154462_at X11L 2.0 enzyme domain, Aminoacyl-tRNA synthetase class I G-protein coupled receptor activity, 149874_at CG9918 2.0 Rhodopsin-like GPCR superfamily neuropeptide receptor activity 141652_at CG5290 2.0 TPR repeat , TPR-like
142203_at CG14788 2.0 GTP-binding protein HSR1-related, GTP-binding domain
G-protein coupled receptor activity unknown 152436_at CG12290 G-protein coupled receptor-like 2.0 Rhodopsin-like GPCR superfamily ligand, rhodopsin-like receptor activity SINV specific (29 genes)
Probe number Gene name Synomymus SDV * Putative function Key words
structural protein of ribosome; small-subunit 142031_at RpS6 ribosomal protein S6 8.3 cytosol ribosomal protein 151466_at CG14599 3.8 cyclin-dependent protein kinase regulator 150138_at CG31232 2.8 Cyclin activity oxidoreductase activity acting on CH-OH group Short-chain dehydrogenase/reductase SDR, Rhodopsin-like 144428_at CG3603 2.6 of donors, acetoacetyl-CoA reductase activity GPCR superfamily
150711_at CG17189 2.6 Odorant binding protein
149283_at CG12585 2.5
149489_at CG7459 copper transporter-like 2.4 copper ion transporter activity Ctr copper transporter
151137_r_at IM4 Immune induced protein 4 2.3 defense/immunity protein activity
General substrate transporter, Sugar transporter 147027_at CG30035 2.3 sugar transporter activity superfamily
141289_at CG9821 2.3
142089_at BG:DS00941.14 2.3
female-specific independent of 150335_at fit 2.3 transformer 154079_at BCL7-like 2.2 BCL7 N-terminal
peroxidase activity, non-selenium glutathione Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ 146946_s_at Prx2540-2 Peroxiredoxin 2540 2.2 peroxidase activity Mal allergen
153378_at Cg25C Collagen type IV 2.2 structural protein Collagen helix repeat, Collagen triple helix repeat
149564_at CG9386 2.2
152347_at CG11841 serine protease 2.2 serine-type endopeptidase activity Peptidase trypsin-like serine and cysteine proteases
150052_at CG31267 2.2 serine-type endopeptidase activity Peptidase trypsin-like serine and cysteine proteases
144239_at la costa 2.2
148228_at CG10592 alkaline phosphatase-like 2.1 alkaline phosphatase activity Alkaline phosphatase
151358_at CG14189 2.1
150743_at CG31058 2.1 ligand binding or carrier
1-phosphatidylinositol-4- 1-phosphatidylinositol-4-phosphate 5-kinase 147724_at PIP5K59B 2.1 Phosphatidylinositol-4-phosphate 5-kinase phosphate kinase activity
147206_at L Lobe 2.1
153731_at Hsp26 Heat shock protein 26 2.0 heat shock protein activity Heat shock protein Hsp20, chaperone
145020_at CG12175 2.0 transcription factor
148888_at CG4893 2.0 P25-alpha
146673_at CG11211 C-type lectin-like 2.0 mannose binding, lectin_c;sugar binding C-type lectin
151945_at RPE65 2.0 beta-carotene 1515'-monooxygenase activity Retinal pigment epithelial membrane protein DCV & FHV specific (39 genes) Probe number Gene name Synomymus DCV * FHV * Putative function Key words 141374_at AttA Attacin-A 8.7 5.2 Gram-negative antibacterial peptide activity Attacin N and C-terminal region 143334_at scb scab 7.9 3.5 calcium-dependent cell adhesion molecule activity Integrins alpha chain 146991_at CG9080 Listericin 7.0 3.6 147421_at CG14499 5.7 6.7 147473_at DptB Diptericin B 5.0 3.7 antibacterial peptide activity Attacin C-terminal region 147685_at CG4269 4.9 2.0 147220_s_at AttB Attacin-B 4.7 4.9 antimicrobial peptide activity Attacin N and C-terminal region 147406_at CG10910 4.3 3.1 structural protein specific RNA polymerase II transcription factor 151822_at Rel Relish 3.5 4.1 NF-kappa-B/Rel/dorsal activity 147127_s_at CG13323 3.2 2.3 143126_at dm diminutive 3.2 2.8 DNA binding, transcription factor activity Basic helix-loop-helix dimerization domain bHLH 152356_at CG32412 3.1 3.5 glutaminyl-peptide cyclotransferase activity Peptidase M28 glutaminyl cyclase 152901_at CG10383 3.0 2.6 ARM repeat fold triacylglycerol lipase activity, lipase;catalytic 141233_at CG5966 triacylglycerol lipase 2.8 3.9 Esterase/lipase/thioesterase activity 153553_at CG18273 2.8 2.4 specific RNA polymerase II transcription factor 143186_at h hairy 2.7 3.0 Basic helix-loop-helix dimerization domain bHLH activity, specific transcriptional repressor activity 146364_at CG5953 2.7 2.1 141483_at CG17836 2.7 2.6 protein dimerization activity, AT_hook;DNA binding HMG-I and HMG-Y DNA-binding domain (A+T-hook) G protein linked receptor- 149715_at mthl5 2.7 2.1 G-protein coupled receptor activity G-protein coupled receptor family 2 (secretin-like) like helicase activity, general RNA polymerase II 153722_at Xpd Xeroderma pigmentosum D 2.7 2.0 ATP-dependent helicase DEAH-box, Helicase c2 transcription factor activity 141271_at CG1021 2.7 2.7 motor
147150_at Attacin-C attacin-like 2.7 4.9 defense/immunity protein
modulator of the activity of 153855_at mae 2.7 3.5 protein binding Ets Peptidase C19 ubiquitin carboxyl-terminal hydrolase family 147126_i_at CG32479 2.6 2.5 Ubiquitin-specific protease activity 2
148424_at CG13311 2.4 2.1 structural molecule activity Alkaline phosphatase
EGF-like domain, Laminin-type EGF-like domain, 151918_s_at drpr draper 2.3 2.1 cell adhesion molecule activity Immunoglobulin/MHC
154372_at tamo 2.3 2.4 nuclear localization sequence binding Zn-finger Ran-binding, Immunoglobulin/MHC
141948_at Replication Protein A 70 replication protein A 70 2.3 2.0 single-stranded DNA binding 149642_at CG31272 sugar transporter-like 2.2 2.1 transporter activity General substrate transporter 153631_at CG8675 2.2 2.9 protein-tyrosine-phosphatase activity, cytokine Fibronectin type III, H+-transporting two-sector ATPase 142932_at dome domeless 2.1 2.3 binding alpha/beta subunit
151326_at CG32666 2.1 2.5
152225_at kraken kraken 2.1 3.1 serine hydrolase activity Alpha/beta hydrolase, Esterase/lipase/thioesterase
150549_at CG11819 2.1 2.6 protein kinase C2 calcium/lipid-binding domain CaLB 141265_at SH3PX1 2.0 3.0 SH3, Phox-like 153278_at Cct5 T-complex Chaperonin 5 2.0 2.6 chaperonin ATPase activity Chaperonin Cpn60/TCP-1, GroEL-like chaperone ATPase 150583_at CG31436 2.0 2.2 Protein of unknown function DUF227 153688_at CG16718 2.0 2.3 Protein of unknown function DUF590 146100_at CG13117 2.0 3.9 DCV & SINV specific (3 genes)
Probe number Gene name Synomymus DCV * SDV * Putative function Key words
145171_at CG14948 dpr18 2.2 1.7 Immunoglobulin-like
149738_r_at CG14742 2.2 1.7
151211_at CG16844 Immune induced molecule 3 2.0 1.8 defense/immunity protein FHV & SINV specific (127 genes) Probe number Gene name Synomymus FHV * SDV * Putative function Key words 145820_at TotM Turandot M 47.4 42.4 Stress-inducible humoral factor Turandot cathepsin L activity, Peptidase_C1;cysteine-type 152626_at CG11459 cathepsin L-like (inactive) 17.0 12.4 Peptidase C1A papain peptidase activity
144790_at CG2909 9.1 4.6
152902_at CG10341 8.4 2.8 NAF1
141701_at CG2064 8.3 4.5 adh_short;oxidoreductase activity Short-chain dehydrogenase/reductase SDR
149723_at CG12224 8.1 5.8 oxidoreductase activity Aldo/keto reductase 151551_i_at CG30090 serine protease 8.0 6.1 trypsin;trypsin activity Peptidase trypsin-like serine and cysteine proteases Asparaginase/glutaminase, AMP-dependent synthetase 144460_at CG6428 asparaginase 7.8 3.3 Lysophospholipase activity and ligase 147195_at CG12505 7.3 5.1 Retrotransposon gag protein, Zn-finger CCHC type
145788_at CG3008 6.6 3.5 protein kinase activity Ribulose bisphosphate carboxylase small chain
152598_at GstE1 Glutathione S transferase E1 6.4 2.5 glutathione transferase activity Glutathione S-transferase 149123_at trbl tribbles 6.4 3.5 protein serine/threonine kinase activity Protein kinase 147139_at CG10799 6.3 4.0 Peptidase M neutral zinc metallopeptidases zinc-binding 142206_s_at CG14527 5.4 4.2 Peptidase_M13_N;metallopeptidase activity site ATP-binding cassette ABC_membrane;ATP-binding cassette (ABC) ABC transporter, Nitrogenase component 1 alpha and beta 153894_at CG11897 5.4 2.6 transporter transporter activity subunits 149222_at CG7130 5.2 2.4 heat shock protein activity Heat shock protein DnaJ 150398_at CG4725 5.1 3.2 Peptidase_M13_N;metallopeptidase activity Peptidase M13 neprilysin
144845_at CG15203 5.0 3.0
OB-fold nucleic acid binding domain, Replication factor-A 142545_at RpA-70 Replication Protein A 70 5.0 2.5 single-stranded DNA binding protein 1 Peptidase S1 chymotrypsin, Low density lipoprotein- 148446_at Tequila 5.0 4.8 serine-type endopeptidase activity, chitin binding receptor class A, Chitin binding Peritrophin-A L-lactate dehydrogenase activity, 143201_at ImpL3 Ecdysone-inducible gene L3 4.9 2.1 Lactate/malate dehydrogenase ldh;oxidoreductase activity
155131_at CG9424 4.8 2.3 Lamino-associated polypeptide 2/emerin
151210_at CG16836 4.6 3.8
151310_at CG8620 4.6 4.5
149467_at CG2791 4.5 2.4 enzyme
153695_at CG6769 4.5 2.5 transcription factor Zn-finger C2H2 type
147525_at CG16898 4.5 2.3 Protein of unknown function DUF227 T-complex protein 1 beta- Chaperonin Cpn60/TCP-1, ATP-dependent helicase DEAD- 142977_at CG7033 4.4 3.1 chaperone activity subunit box 149755_at GstD9 Glutathione S transferase D9 4.4 2.3 glutathione transferase activity Glutathione S-transferase 144521_at CG15784 4.4 2.4 Winged helix DNA-binding 142142_at CG4721 4.3 2.4 Peptidase_M13_N;metallopeptidase activity Peptidase M13 neprilysin ATP-binding cassette 154740_at CG31793 4.3 3.0 ATP-binding cassette (ABC) transporter activity ABC transporter, Ribonucleotide reductase R1 subunit transporter-like trans-12-dihydrobenzene-12-diol dehydrogenase 142258_at CG12766 4.0 2.2 Aldo/keto reductase activity 147433_at CG15067 4.0 3.3 Cytochrome c 142969_at Cys Cystatin-like 4.0 4.0 cysteine protease inhibitor activity Sarcocystatin, Cysteine protease inhibitor
141583_at Cyp6a20 cytochrome P450 CYP6A20 3.9 2.1 cytochrome P450 activity Cytochrome P450, E-class P450 group I
145956_at CG5958 retinoid binding protein-like 3.9 2.2 retinal binding Cellular retinaldehyde-binding)/triple function
150031_at CG17560 3.9 3.5 Male sterility protein
142737_at CG5059 3.9 2.4
147912_at CG13877 3.7 3.4 phosphoserine transaminase activity, 153150_at CG11899 3.7 2.4 Phosphoserine aminotransferase aminotran_5;transaminase activity Structure specific DNA secondary structure binding, single-stranded 141661_at Ssrp 3.6 2.1 HMG1/2 (high mobility group) box recognition protein RNA binding
141242_at CG15092 3.6 2.6
protein serine/threonine kinase activity, JUN kinase 148051_at msn misshapen 3.6 2.1 Serine/threonine protein kinase kinase kinase kinase activity 153629_at mre11 meiotic recombination 11 3.6 2.1 endonuclease activity, exonuclease activity Metallo-phosphoesterase, DNA repair exonuclease
143198_at Hsp83 Heat shock protein 83 3.5 2.1 chaperone activity, HATPase_c;ATP binding Heat shock protein Hsp90
155148_at CG10527 3.5 3.5 farnesoic acid O-methyltransferase activity Protein of unknown function DM9
148108_at CG12012 3.5 2.6
144724_at CG7267 3.5 2.6
leucine-tRNA ligase activity, tRNA-synt_1;tRNA Aminoacyl-tRNA synthetase class Ia, Haem peroxidase 151752_s_at CG33123 leucine--tRNA ligase 3.4 2.1 ligase activity plant/fungal/bacterial neprilysin-like Peptidase M neutral zinc metallopeptidases zinc-binding 145896_at CG9508 3.4 2.0 neprilysin activity metalloendopeptidase site
149340_at rev7 3.4 2.2 cell cycle regulator DNA-binding HORMA
chaperonine-containing T- 153982_at Cct 3.4 2.1 chaperonin ATPase activity Chaperonin Cpn60/TCP-1, GroEL-like chaperone ATPase complex gamma-subunit
145620_at CG4259 3.4 2.3 serine-type endopeptidase activity Peptidase trypsin-like serine and cysteine proteases
152325_at Lsd-1 Lipid storage droplet-1 3.4 3.4 chaperone Perilipin 147353_at CG11400 3.4 3.1
154266_at Ada2S Transcriptional adapter 2S 3.3 2.1 histone acetyltransferase activity Myb DNA-binding domain, Homeodomain-like
triacylglycerol lipase activity, sterol esterase 146165_at CG6113 triacylglycerol lipase-like 3.3 2.9 Alpha/beta hydrolase, Esterase/lipase/thioesterase activity
152063_at CG4716 3.2 2.5
Adenosine deaminase- 148973_at Adgf-A 3.2 2.7 adenosine deaminase activity Adenosine/AMP deaminase related growth factor A
142599_at CG31151 3.2 2.2 BAH;DNA binding Bromo adjacent region
149964_at CG14872 3.2 2.6 Lipocalin-related protein and Bos/Can/Equ allergen
154938_at CG1583 3.1 2.8 phospholipase A2 activity Phospholipase A2
146000_at CG7219 serpin 3.1 2.5 serine-type endopeptidase inhibitor activity Serpin
150482_at CG13607 3.1 2.3
142893_at Rtnl1 3.0 2.7 Reticulon, Calcium-binding EF-hand
150713_at CG6066 3.0 2.5 Protein of unknown function DUF926
147319_at CG8317 3.0 2.1
143845_at Rab6 Rab-protein 6 2.9 2.4 RAB small monomeric GTPase activity Ras GTPase superfamily
147564_at CG16799 lysozyme 2.9 2.4 defense/immunity protein activity, lysozyme activity Glycoside hydrolase family 22
145648_at Cyp309a2 2.9 2.9 cytochrome P450 activity Cytochrome P450, E-class P450 group I
141815_at PHGPx 2.9 2.0 glutathione peroxidase activity Glutathione peroxidase
141688_at ImpL2 Ecdysone-inducible gene L2 2.9 2.1 cell adhesion molecule activity Immunoglobulin subtype
transmembrane receptor protein serine/threonine 153075_at CG1773 serine protease-like 2.9 2.3 Peptidase trypsin-like serine and cysteine proteases kinase receptor-associated protein activity
145608_at CG15358 C-type lectin-like 2.9 2.0 lectin_c;sugar binding C-type lectin
152320_at CG6495 2.9 2.1 receptor Low density lipoprotein-receptor class A
147337_at CG6429 2.8 2.4
151967_at CG6415 aminomethyltransferase 2.8 2.1 aminomethyltransferase activity Glycine cleavage T protein (aminomethyl transferase)
Retinoid- and fatty-acid structural molecule activity, Vitellogenin_N;lipid 151538_s_at RfaBp 2.8 3.0 von Willebrand factor type D, Lipid transport protein binding protein transporter activity
143197_at Hsp68 Heat shock protein 68 2.8 2.6 heat shock protein activity Heat shock protein Hsp70
146311_at CG9928 2.7 2.1
148547_at Mocs1 2.7 2.0
152385_at Aats-gln Glutaminyl-tRNA synthetase 2.7 2.3 glutamine-tRNA ligase activity, ATP binding Glutamyl-tRNA synthetase class Ic
150616_at CG31380 2.7 2.3 Protein of unknown function DUF227
146558_at CG14400 2.7 2.4
151575_at CR32218 2.6 2.0 motor
149884_at CG9616 2.6 3.1
sodium-dependent 150628_at CG8932 2.6 2.0 sodium dependent multivitamin transporter activity Na+/solute symporter multivitamin transporter-like
151468_s_at egh egghead 2.6 2.6 beta-14-mannosyltransferase activity Peptidylprolyl isomerase FKBP-type
calcium-independent calcium-independent cytosolic phospholipase A2 142906_at CG6718 2.6 2.1 Patatin, Ankyrin phospholipase A2 activity Ubiquitin-associated domain, UBA-like, Zn-finger C2H2 148369_at CG8209 2.5 2.1 type
147607_at Glycogenin Glycogenin 2.5 2.1 glycogenin glucosyltransferase activity Glycosyl transferase family 8
144701_at CG12116 2.5 2.0 sepiapterin reductase activity
152613_at CG11255 adenosine kinase 2.5 2.3 adenosine kinase activity Carbohydrate kinase PfkB, Adenosine kinase
151841_at CG8586 2.5 2.1 serine-type endopeptidase activity Peptidase S1 chymotrypsin
replication factor A 30 kD 153194_at CG9273 2.5 2.3 DNA binding, tRNA_anti;nucleic acid binding OB-fold nucleic acid binding, Winged helix DNA-binding subunit
146526_at CG10680 2.5 2.7
144590_at CG32918 2.5 2.2 hydrogen-exporting ATPase activity 146216_at l(2)06225 ATP synthase g-subunit 2.5 2.1 Mitochondrial ATP synthase gamma phosphorylative mechanism
142954_at CG5773 2.5 2.3
151839_at CG31764 vir-1 2.4 2.1
cathepsin B activity, Peptidase_C1;cysteine-type 153218_at CG3074 2.4 2.3 Peptidase C1A papain, Somatomedin B peptidase activity Longevity-assurance protein (LAG1), TRAM LAG1 and 154405_at CG11642 2.4 2.2 CLN8 homology actin binding, calcium-dependent phospholipid 153673_at AnnIX Annexin IX 2.4 2.1 Annexin type V binding 142414_at CG11315 2.4 2.3 E1 protein and Def2/Der2 allergen
152591_at CG11395 2.4 2.0 structural protein
146726_at nec necrotic 2.4 2.3 serine-type endopeptidase inhibitor activity Serpin
146136_at Hand 2.3 3.1 transcription factor activity Basic helix-loop-helix dimerization domain bHLH
142768_at CG7407 2.3 2.2
glass multimer reporter 153313_at Rac2 2.3 2.8 small monomeric GTPase activity Ras GTPase superfamily construct of Nolan
151980_at CG5150 alkaline phosphatase-like 2.3 2.4 alkaline phosphatase activity Alkaline phosphatase
149053_at CG9451 acid phosphatase 2.2 2.5 acid phosphatase activity Histidine acid phosphatase Peptidase S9 prolyl oligopeptidase, 145223_at CG9059 dipeptidyl-peptidase IV-like 2.2 2.2 dipeptidyl-peptidase IV activity Esterase/lipase/thioesterase phenylalanine 4-monooxygenase activity, Aromatic amino acid hydroxylase, Phenylalanine-4- 153434_at Hn Henna 2.2 2.2 ACT;amino acid binding hydroxylase tetrameric form
155042_at scrib scribbled 2.2 2.2 cell proliferation Leucine-rich repeat, PDZ/DHR/GLGF domain
147665_at CG3290 alkaline phosphatase 2.2 2.1 alkaline phosphatase activity Alkaline phosphatase
144147_at BM-40-SPARC SPARC/ostenectin-like 2.1 2.0 ligand binding or carrier Calcium-binding EF-hand, Osteonectin-like
151851_at CG6206 alpha-mannosidase 2.1 2.2 alpha-mannosidase activity Glycoside hydrolase family 38
153583_at Hsp23 Heat shock protein 23 2.1 2.3 heat shock protein activity Heat shock protein Hsp20
145890_at CG9498 2.1 2.0 Protein of unknown function DUF227
150030_at CG17562 2.1 2.2 enzyme Male sterility protein
147336_at CG6426 calcium binding protein-like 2.0 2.9 ligand binding or carrier Destabilase, Calcium-binding EF-hand
4-nitrophenylphosphatase- 144903_at CG10352 2.0 2.0 4-nitrophenylphosphatase activity Haloacid dehalogenase-like hydrolase like
153365_at CG15825 2.0 2.1
143917_at lush lush 2.0 2.4 odorant binding Insect pheromone/odorant binding protein PhBP
ATP-binding cassette 145598_at CG17646 2.0 2.5 ATP-binding cassette (ABC) transporter activity ABC transporte, AAA ATPase transporter
152488_at CG8343 2.0 2.0 mannose binding, lectin_c;sugar binding C-type lectin
* Fold induction compared to Tris injection control Supplemental Table III: List of the 42 genes up-regulated by DCV, FHV and SINV
Fold induction Probe number Gene name Synomymus DCV FHV SINV E. c M. l B. b L. m Putative function 153941_at Fst Frost 19.7 10.9 2.9 16.9 23.8 8.6 15.5 Respond to cold. Stress response. 153231_at CG8791 7.5 3.7 2.5 3.5 -4.8 1.0 4.5 High affinity inorganic phosphate:sodium symporter activity 146285_at CG31764 Vir-1 7.1 9.5 4.6 4.1 3.1 1.9 3.7 Unknown, response to virus 145307_at CG15043 6.9 7.3 2.1 3.6 4.7 3.9 2.3 Unknown 146814_at CG12780 GNBP-like 6.5 5.4 3.1 1.6 1.9 2.2 2.7 Gram-negative bacterial cell surface binding 144846_at CG2081 Vago 5.3 6.0 4.7 1.0 0.9 1.0 1.5 Unknown, antiviral activity 141626_at CG7635 Mec2 4.8 2.9 2.2 2.7 2.9 4.0 2.5 Unknown, Band 7 protein; Stomatin 141353_at CG6687 Serpin 88Eb 4.5 10.3 6.5 2.7 5.0 7.4 5.7 Serine protease inhibitor Autophagic cell death. Pheromone/general odorant binding 150837_at Obp99b Odorant-binding protein 99b 3.8 10.8 4.6 0.2 0.2 0.2 0.3 protein 152122_at CG10912 3.6 7.7 2.3 1.6 1.8 2.4 2.7 Protein of unknown function DUF725 144998_at CG15745 3.4 10.9 8.5 2.3 2.7 2.7 2.5 Unknown 152721_at Idgf1 Imaginal disc growth factor 1 3.4 3.2 2.8 2.3 2.0 1.8 2.1 Chitinase II; Glycoside hydrolase, family 18 153233_at CG6357 3.3 4.9 2.6 1.3 1.7 2.0 2.5 Cysteine-type endopeptidase activity. 144882_at PGRP-SA 3.2 3.9 2.9 3.6 3.6 2.6 7.5 Peptidoglycan recognition 147430_at CG15066 IM23 3.1 2.2 3.2 7.8 16.4 19.0 1.6 Unknown 146256_at CG14934 Mal-B1 (Maltase B1) 3.1 7.7 3.7 1.0 1.6 1.0 1.1 Alpha amylase; Glycoside hydrolase, 149782_at Hsp70Bc 3.1 5.5 5.4 0.7 8.2 2.0 4.8 Heat shock protein 70 149477_at CG11671 3.1 5.0 2.0 1.1 1.5 2.3 2.1 Unknown 152112_at CG13625 2.9 2.4 2.1 1.3 1.5 2.1 1.0 Unknown 152183_at CG4680 2.9 13.7 8.6 0.8 0.9 1.4 3.1 Unknown N-methyl-D-aspartate receptor-associated 142415_at Nmda1 2.7 4.9 2.9 1.8 1.7 1.6 1.7 N-methyl-D-aspartate selective glutamate receptor activity protein 143682_at Tig Tiggrin 2.6 3.9 3.4 1.2 1.8 2.0 1.7 Haem oxygenase-like, multi-helical. 149139_at CG4786 Rcd2 (Reduction in Cnn dots 2) 2.6 3.2 2.5 8.8 8.1 2.7 1.5 Unknown, von Willebrand factor, type C 141511_at dos daughter of sevenless 2.5 4.9 2.8 2.2 3.2 2.9 1.0 Regulation of Ras protein signal transduction NAD-dependent methylenetetrahydrofolate NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/ 151767_at Nmdmc 2.5 5.4 5.1 2.8 3.6 0.8 1.3 dehydrogenase cyclohydrolase CHMP2B (Charged multivesicular body 154760_at CG4618 2.5 2.5 2.3 1.7 2.7 2.9 1.8 Unknown protein 2b) 146873_at Cyp4p3 2.5 2.1 2.0 3.4 4.8 3.6 2.0 Cytochrome P450, E-class, group I 154821_at CG8147 2.5 5.1 4.6 1.0 0.3 1.0 0.4 Alkaline phosphatase-like 153197_at Eip75B Ecdysone-induced protein 75B 2.5 3.3 2.1 1.3 1.3 1.8 2.7 Nuclear hormone receptor, 153527_at CG1572 2.4 2.1 2.0 1.1 1.2 1.1 0.8 Unknown, MARVEL-like domain 143005_at CG4199 2.4 5.8 4.5 2.3 2.5 1.8 1.4 FAD/NAD-linked reductase 150036_at CG14907 2.4 5.4 2.6 2.3 2.1 2.7 2.7 Unknown 154140_at CG4713 l(2)gd1 (lethal (2) giant discs 1) 2.4 3.3 2.3 0.8 1.2 1.6 1.2 C2 calcium-dependent membrane targeting 146708_at Tsp42Ed Tetraspanin 42Ed 2.4 4.0 2.5 1.5 1.4 2.0 2.2 Unknown 144068_at IM2 Immune induced molecule 2 2.4 2.6 2.7 2.7 4.1 3.5 1.4 Unknown 143802_at CG14906 2.3 4.4 2.8 1.3 1.3 1.7 0.9 Methyltransferase activity 147410_at CG10911 2.3 2.9 2.3 1.4 1.4 1.5 1.2 Protein of unknown function DUF725 141685_at CG3066 Sp7 (Serine protease 7) 2.2 4.1 3.0 1.9 2.0 1.8 4.1 Clip domain chymotrypsin-type peptidase 143401_at Uro Urate oxidase 2.2 2.2 2.1 3.8 5.0 5.5 2.0 Urate oxidase activity 152618_at Tsp42El Tetraspanin 42El 2.1 4.0 2.2 0.8 0.9 1.4 1.5 Unknown 148843_at CG13075 2.1 3.1 2.2 4.5 5.8 3.8 4.7 Chitin binding 155151_at CG10916 2.0 6.7 4.3 1.3 1.2 1.7 2.1 Zinc ion binding
Upregulation superior to 2-fold is shown in bold. Data for Escherichia coli (E.c), Micrococcus luteus (M.l) and Beauveria bassiana (B.b) are from Ref 19. Data for Listeria monocytogenes (L.m) are from Ref 30.