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Gene C Profile Test Results GeneGc Profile Test Results Horse: ByeMe Champagne Owner: Wendall, Jane Horse and Owner Informaon Horse ByeMe Champagne DOB 6/1/2007 Breed Paint Age 7 Color Classic Champagne Sex S Discipline Western Height 14.2 Registry APHA Reg. Number 12345 Sire Bye Bye Baby Dam Super Champagne Sire Reg. 9058-234 Dam Reg. 4314-334 Comments: Excellent Temperament Owner Wendall, Jane Address Tinseltown Phone 555-1212 City Hollywood, CA E-mail [email protected] Zip Code 91604 GeneGc Profile Test Results Horse: ByeMe Champagne Owner: Wendall, Jane Results Summary Coat Color : ByeMe Champagne has one Black allele and one Red allele making the Base coat appear Black. Also detected were single Champagne and Cream alleles; likely resulUng in a rare Champagne Cream color. One copy of the Frame Overo allele is also detected, indicang underlying white patches (hidden By CH). As a result of single gene copies in each of the following, he has a 50% chance of passing Black or Red, Cream and/or Champagne, AgouU and/or Frame Overo alleles to his offspring. Allele Summary: Aa, Ee, Ch, Cr, LWO/n Traits: ByeMe Champagne is a not a carrier of any known recessive disease genes. CauUon is recommended however, as any mare Bred to him should Be Frame Overo negave as to avoid a 25% chance of foal death (+/+ LWO results in a lethal condiUon at Birth). He may also throw Gaited foals when Bred to Gaited (+) mares. Notes: Please note that your analysis is ongoing and may include some regions marked with an asterisk denoUng the following: * Discovery – This gene detecUon is in the early stages of discovery and will have varying reliability results ** Inconclusive – Not a Bad omen! Simply put, the gene of interest did not reveal itself (neither a posiUve nor a negave = no result, unknown) GeneGc Profile Test Results Horse: ByeMe Champagne Owner: Wendall, Jane Coat Color/PaLerns Results AgouG +/- MC1R Aa – One dominant AgouU allele detected More about Agou% Black/Red +/- MC1R E/e One Black and one Red allele detected More about Black/Red Brindle (IP) -/- IKBKG No Brindle IP alleles detected More about Brindle Champagne +/- SLC36 Ch/ch – One Champagne allele detected More about Champagne Cream +/- SLC36 Cr/cr – One Cream allele detected More about Cream Dominant White -/- KITL No Dominant White alleles detected (DW 1-20) More about D. White Frame Overo +/- EDNRB LWO/- - One Frame Overo allele detected More about Overo Grey -/- STX17A No Grey alleles detected More about Grey Pearl Inconclusive (Couture panel only) More about CS Pearl Sabino -/- KITL No Sabino alleles detected More about Sabino Silver -/- PMEL17 No Silver alleles detected More about Silver Splashed White -/- MITF No Splashed White alleles detected (SW 1-4) More about S White Tobiano -/- E2 No ToBiano alleles detected More about Tobiano White SpoTng -/- PAX3 No White Spong alleles detected More about Spong GeneGc Profile Test Results Horse: ByeMe Champagne Owner: Wendall, Jane Health GeneGcs AIS -/- AR No androgen insensivity detected More about AIS Cereb. Abiotrophy -/- MUTYH No CereBellar ABiotrophy genes detected More about CA EAV SuscepGbility* 12/16 ECA11 Unknown Equine Arteritus Viral suscepUBility More about EAV No Foal Immunodeficiency Syndrome genes FIS -/- SLC5A3 More about FIS detected No Glycogen Branching Enzyme Deficiency alleles GBED -/- GBED1 More about GBED detected No Hereditary Equine Regional Dermal Asthenia HERDA -/- PPIB More about HERDA alleles detected HYPP -/- SCN4A No Hyperkalemic Periodic Paralysis alleles detected More about HYPP IAR - SubFerGlity -/+; -/- FKBP6 One suBferUlity allele detected, likely no effect More about IAR JEB1 -/- LAMC2 No JuncUonal Epidermolysa Bullosis detected More about JEB1 Lavender Foal Synd. -/- MYO5A No Lavender Foal alleles detected More about LFS MH -/- RYR1 No Malignant Hyperthermia alleles detected More about MH Myotonia -/- CLCN4 No Myotonia alleles detected More about Myotonia PSSM -/- GYS1 No Polysaccharide Storage Myopathy detected More about PSSM SCID -/- DNAPK No SCID alleles detected More about SCID West Nile* -/- WNVR Normal suscepUBility to West Nile Virus More about WNVR GeneGc Profile Test Results Horse: ByeMe Champagne Owner: Wendall, Jane Trait Genecs Lordosis* 0/8 ECA20 No lordosis risk alleles present More about Lordosis Curiosity/ Two Curiously alleles detected. Likely more +/+ DRD4 More about C/V Vigilance* curious MyostaGn/Speed +/+ MSTN C/C - Likely sprint, faster, short distances More about Myosta%n Gait +/- DMRT3 Likely carrier of gaited allele (Loss of Canter) More about Gait GeneGc Profile Test Results Horse: ByeMe Champagne Owner: Wendall, Jane Coat Color Inheritance Probabilies 2 Alleles 1 Allele 0 Alleles Bay/Agouti Black Brindle Champagne Cream Dom. White Frame Sabino Splashed White White Base Overo White Markings Spots Coat Color Inheritance Probabilies: The Bar graph above depicts the numBer of alleles for specific coat color phenotypes Based upon ByeMe Champagne’s geneUc tesUng results. Filled in red represents the proBability that offspring of ByeMe Champagne will have that coat phenotype. GeneGc Profile Test Results Horse: ByeMe Champagne Owner: Wendall, Jane Health GeneGcs High Proportion Non−Risk Alleles Medium Proportion Risk Alleles Low EAV IAS Lordosis MulG-allele Risk Graph: The proporUon of risk alleles carried By ByeMe Champagne for each of these health traits is graphed above. More red indicates ByeMe Champagne carries more risk alleles. Note that for most of these traits, risk is only present if the horse is a carrier of all of the risk alleles. GeneGc Profile Test Results Horse: ByeMe Champagne Owner: Wendall, Jane Health GeneGcs EAV (12/16) Lordosis (0/8) IAR (1/4) MulG-allele Risk Graph: Each Bar indicates a trait and each Box indicates a disUnct risk site that act in comBinaon towards the trait. A red Box indicates the horse carriers 2 risk alleles at the site, an orange Box indicates 1 risk allele, and a grey Box indicates 0 risk alleles. An all red Bar indicates that the horse carries two risk alleles at each risk site and is likely affected. A Bar filled completely with orange and red indicates the horse may Be a carrier. Otherwise, the horse is not a likely a carrier of the risk allele. GeneGc Profile Test Results Horse: ByeMe Champagne Owner: Wendall, Jane Defining GeneGcs & More InFo Allele - One of two or more alternave forms of a gene that arise By mutaon and are found at the same place on a chromosome. Gene - A unit of heredity that is transferred from a parent to offspring and is thought to determine some characterisUc of the offspring Genotype - The geneUc consUtuUon or make up of an individual organism Heterozygous - A pair of genes which are different (not the same). One is typically dominant and one recessive Homozygous - A pair of genes that are idenUcal (of one type) Phenotype - The oBservable or visiBle characterisUcs of an individual resulUng from their genotype or the interacUon of their various genes and environment. The results depicted in this report do not consUtute veterinary or medical advice. Any medical or veterinary advice should Be sought from your veterinarian regarding these results or any health issues or quesUons you may have about your animal. Breed, sex, gene interacUon, unknown genes and individual variances may impact the results/ phenotypes/Behaviors in any animal in unknown and unpredictable ways. Please Be advised that your animals’ health is important to us and you should feel free to contact us should you have any further quesUons or feedBack on our diagnosUc plaorm, results reporUng or general quesUons. We value your input & thank you! .
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