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Assessment Report on Juglans Regia L., Folium Based on Article 16D(1), Article 16F and Article 16H of Directive 2001/83/EC As Amended (Traditional Use)

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Assessment Report on Juglans Regia L., Folium Based on Article 16D(1), Article 16F and Article 16H of Directive 2001/83/EC As Amended (Traditional Use) 15 January 2013 EMA/HMPC/346740/2011 Committee on Herbal Medicinal Products (HMPC) Assessment report on Juglans regia L., folium Based on Article 16d(1), Article 16f and Article 16h of Directive 2001/83/EC as amended (traditional use) Draft Herbal substance(s) (binomial scientific name of Juglans regia L., folium the plant, including plant part) Herbal preparation(s) Juglans regia L., leaves cut and dried b) Herbal preparations Comminuted herbal substance Pharmaceutical forms Comminuted herbal substance for preparation of decoction for cutaneous use Rapporteur Assessor(s) Note: This Assessment Report is published to support the release for public consultation of the draft Community herbal monograph on Juglans regia L., folium. It should be noted that this document is a working document, not yet edited, and which shall be further developed after the release for consultation of the monograph. Interested parties are welcome to submit comments to the HMPC secretariat, which the Rapporteur and the MLWP will take into consideration but no ‘overview of comments received during the public consultation’ will be prepared in relation to the comments that will be received on this assessment report. The publication of this draft assessment report has been agreed to facilitate the understanding by Interested Parties of the assessment that has been carried out so far and led to the preparation of the draft monograph. 7 Westferry Circus ● Canary Wharf ● London E14 4HB ● United Kingdom Telephone +44 (0)20 7418 8400 Facsimile +44 (0)20 7523 7051 E -mail [email protected] Website www.ema.europa.eu An agency of the European Union © European Medicines Agency, 2013. Reproduction is authorised provided the source is acknowledged. Table of contents Table of contents ................................................................................................................... 2 1. Introduction ....................................................................................................................... 3 1.1. Description of the herbal substance(s), herbal preparation(s) or combinations thereof .. 5 1.2. Information about products on the market in the Member States ............................... 6 1.3. Search and assessment methodology ..................................................................... 8 2. Historical data on medicinal use ........................................................................................ 8 2.1. Information on period of medicinal use in the Community ......................................... 8 2.2. Information on traditional/current indications and specified substances/preparations .... 9 2.3. Specified strength/posology/route of administration/duration of use for relevant preparations and indications ....................................................................................... 10 3. Non-Clinical Data ............................................................................................................. 12 3.1. Overview of available pharmacological data regarding the herbal substance(s), herbal preparation(s) and relevant constituents thereof ........................................................... 12 3.2. Overview of available pharmacokinetic data regarding the herbal substance(s), herbal preparation(s) and relevant constituents thereof ........................................................... 19 3.3. Overview of available toxicological data regarding the herbal substance(s)/herbal preparation(s) and constituents thereof ....................................................................... 20 3.4. Overall conclusions on non-clinical data ................................................................ 23 4. Clinical Data ..................................................................................................................... 24 4.1. Clinical Pharmacology ......................................................................................... 24 4.1.1. Overview of pharmacodynamic data regarding the herbal substance(s)/preparation(s) including data on relevant constituents ........................................................................ 24 4.1.2. Overview of pharmacokinetic data regarding the herbal substance(s)/preparation(s) including data on relevant constituents ........................................................................ 24 4.2. Clinical Efficacy .................................................................................................. 24 4.2.1. Dose response studies...................................................................................... 24 4.2.2. Clinical studies (case studies and clinical trials) ................................................... 24 4.2.3. Clinical studies in special populations (e.g. elderly and children) ............................ 24 4.3. Overall conclusions on clinical pharmacology and efficacy ........................................ 24 5. Clinical Safety/Pharmacovigilance ................................................................................... 24 5.1. Overview of toxicological/safety data from clinical trials in humans ........................... 24 5.2. Patient exposure ................................................................................................ 25 5.3. Adverse events and serious adverse events and deaths .......................................... 25 5.4. Laboratory findings ............................................................................................. 25 5.5. Safety in special populations and situations ........................................................... 25 5.6. Overall conclusions on clinical safety ..................................................................... 26 6. Overall conclusions .......................................................................................................... 26 Annex .................................................................................................................................. 26 List of references ................................................................................................................. 26 Assessment report on Juglans regia L., folium EMA/HMPC/346740/2011 Page 2/26 1. Introduction The herbal substance of European walnut (Juglans regia L.) leaves is mentioned in several well-known handbooks and sources such as Madaus (1938), Deutschen Arzneibuch (1926), Wren (1975), Ożarowski (1976), Miller and Murray (1998), Blumenthal (2000), Wyk and Wink 2004, Martindale (2009), Wichtl (1994; 2004), PDR for Herbal Medicines (Gruenwald et al.(ed) 2000; 2004), German Comission E Monograph, Gehrman et al. (2005) and Natural Medicines Comprehensive Database (2009). The herbal substance is described as the dried entire –margined leaflets freed from the rachis with faintly aromatic odour and astringent, somwhat bitter and harsh taste (Wichtl , 2004). By long preservation the leaves become brown and lose their aroma. Juglans regia leaves contain ca. 10% tannins (elegitannins). Juglone is unstable and in dry leaves is present only in traces. European walnut belongs to the family of Juglandacae which contains about 50 species in 8 genera. The deciduous tree native in Southeastern Europe, is now cultivated and distributed in North temperate and subtropical regions of Europe, Africa, Asia and America. It is native in a region stretching from the Balkans eastward to the Himalayas and southwest China. The largest forests are in Kyrgyzstan, where trees occur in extensive, nearly pure walnut forests at 1,000–2,000 m altitude. Possibly native in Greece and elsewhere in the Balkan penninsula; widely cultivated and locally naturalized in Europe (Flora Europea 2011). Its Latin name Juglans originates from the Latin Jupiter and glans (acorn) meaning “Jupiter nuts”. Tannins Leafs contains approximately 10% tannins of the ellagitannins type (Blumenthal 2000). According to DAC not less than 2.0%, calculated as pyrogallol (Wichtl, 2004). Naphtalene derivatives Naphthoquinones, oxygen-derivatives of naphthalene. The most known constituent is juglone (5- hydroxy-1,4-naphtoquinone) which occurs in fresh plant (leaf, stain) as glycoside of reduced form: 4β- D-glucoside of α-hydrojuglone=4β-D-glucoside of 1,4,5-trihydroxynaphthalene (2% in the stain, 0.6% in the leaves), but also in free state, particularly in the epicuticular leaf wax (to about 30% ), (Wichtl 2004, Evans 2000,Hazra et al. 2004; Prasad and Gülz 1990). This glucosidic form is decomposing by hydrojuglone-β-D-glucopyranoside-β-glucosidase to juglone (Morant 2008). Juglone is unstable and easily polymerized into yellow, brown and black pigments, so in the older leaves or dry leaves is present only in trace amounts. As dried leaves were used for extract preparation, juglone was not detected, which means that this compound is not suitable for use in quality control of dry plant (Amaral et al. 2004; Babula et al. 2009; Gîrzu et al. 1998; Wichtl 2004; Wójcik 1984). Flavonoids Leaf contains about 3.4% of flavonoids (Wichtl 2004, Carnat et al. 1993), especially quercetin, hyperoside=quercetin 3-O-galactoside (0.6% according to Carnat et al. 1993), and 0.2-0.6% of quercitrin=quercetin 3-O-rhamnoside (Wichtl 2004), kaempferol and kaempferol 3-O- arabinofuranoside have been also isolated (Liu et al. 2004). Several flavonoids (quercetin 3-galactoside, quercetin 3-arabinoside, quercetin 3-xyloside, quercetin 3- rhamnoside and two other partially identified 3-pentosides of quercetin and kaempferol in walnut Assessment report on Juglans
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