Polygenic Transmission Disequilibrium Confirms That Common and Rare Variation Act Additively to Create Risk for Autism Spectrum Disorders
bioRxiv preprint doi: https://doi.org/10.1101/089342; this version posted November 23, 2016. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders Daniel J. Weiner1,2,3, Emilie M. Wigdor1,2,3, Stephan Ripke1,2,3,4, Raymond K. Walters1,2, Jack A. Kosmicki1,2,3,5, Jakob Grove6,7,8,9, Kaitlin E. Samocha1,2,3, Jacqueline Goldstein1,2,3, Aysu Okbay10, Jonas Bybjerg-Grauholm7,11, Thomas Werge7,12,13, David M. Hougaard11, Jacob Taylor1,2,3,14, iPSYCH-Broad Autism Group, Psychiatric Genomics Consortium Autism Group, David Skuse15, Bernie Devlin16, Richard Anney17, Stephan Sanders18, Somer Bishop18, Preben Bo Mortensen6,7,19, Anders D. Børglum6,7,8, George Davey Smith20, Mark J. Daly1,2,3, and Elise B. Robinson1,2,3,* 1Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. 2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. 3Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. 4Department of Psychiatry and Psychotherapy, Charité, Campus Mitte, Berlin, Germany. 5Program in Genetics and Genomics, Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA. 6Department of Biomedicine (Human Genetics), Aarhus University, Aarhus, Denmark. 7Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Copenhagen, Denmark.
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