1 5th

SYMPOSIUM TARRAGONA 1 st / 4 th APRIL 2019

SYMPOSIUM PROGRAM Welcome

Dear colleagues

It is a pleasure to welcome you all to the 15th ISBR Symposium. Our program committee has worked tirelessly to put together Index an interesting and exciting scientific programme. Many volunteers have helped us to organise an array of parallel Welcome 03 sessions and workshops that cover many of the scientific topics Sponsors 04 currently under intense discussion in our scientific community. Symposium organization 06 We are also very honoured to have with us an outstanding group of keynote and plenary speakers. We hope that with Program overview 10 such a program you will all find plenty of opportunities to hear Venue overview 13 about the latest scientific developments in this field, to learn Scientific programme 15 new things and to interact with other scientists, widening your network and fostering new collaborations. Monday, April 1st 15 Tuesday, April 2nd 30 We have chosen the beautiful city of Tarragona to host this Wednesday, April 3rd 48 Symposium for many reasons. With the stunning Mediterranean Sea as the backdrop, the many historical Roman sites and its Thursday, April 4th 59 laid back nature, Tarragona provides a wonderful venue to General information 62 engage in the Symposium at the Palau Firal and then relax and enjoy its many offerings when the sessions are over.

We warmly welcome you and sincerely hope that you enjoy this Symposium and have a pleasant stay in Tarragona.

Dr. Ariel Alvarez Dr. Monica Garcia-Alonso ISBR President Symposium coordinator and local organiser

2 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 3 Sponsors Sponsors

MAJOR SPONSORS OTHER SPONSORS

I  I C I

FRIENDS OF ISBR

4 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 5 Symposium organization Symposium organization

SYMPOSIUM COORDINATOR / LOCAL ORGANISER CAMILLA BEECH > Cambea Consulting Ltd MÒNICA GARCÍA-ALONSO > Estel Consult Ltd / ISBR JENNIFER ANDERSON > Corteva Agriscience™ Agriculture Division of SCIENTIFIC PROGRAM COMMITTEE DowDuPont

MORVEN A. MCLEAN (Chair) > ILSI Research Foundation ISBR ADMINISTRATIVE SUPPORT

VESNA AHERNE CARMEN VICIEN > ISBR > University of Buenos Aires

VIBHA AHUJA COMMUNICATIONS SUPPORT > Biotech Consortium India Limited JILL KUEHNERT > Seed Stories HENNIE GROENEWALD > Biosafety South Africa

HEIDI MITCHELL > Office of the Gene Technology Regulator

JOERG ROMEIS > Agroscope

6 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 7 Symposium organization Symposium organization

ISBR BOARD SPONSORSHIP COMMITTEE

ARIEL ALVAREZ-MORALES (ISBR President) KAREN HOKANSON (Chair) > Center for Research and Advanced Studies – CINVESTAV > University of Minnesota

RALF WILHELM ANDREW ROBERTS (ISBR Treasurer) > Julius Kühn-Institut > ILSI Research Foundation

DONALD MACKENZIE JENNIFER ANDERSON > Donald Danforth Plant Science Center > Corteva Agriscience™ Agriculture Division of DowDuPont

ANDREW ROBERTS JUSTIN MACDONALD > ILSI Research Foundation > Syngenta

JOE SMITH (ISBR President Elect) DONALD MACKENZIE > Office Of The Gene Technology Regulator (Retired) > Donald Danforth Plant Science Center

MONICA GARCIA-ALONSO DONNA RAMAEKER > Estel Consult Ltd. > Program for Biosafety Systems

ALAN GRAY ANDRE ROSADO > Centre for Ecology and Hydrology (Retired) > International Centre for Genetic Engineering and Biotechnology (ICGEB) KAREN HOKANSON > University of Minnesota PATRICK RUDELSHEIM > Perseus BVBA

JOACHIM SCHIEMANN > Julius Kühn-Institut (Retired)

8 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 9 Program overview Program overview 6 Isis Room 6 (cont’d) Workshop Workshop Workshop Room Medusa Parallel Session 4 5 Room Minerva 5 (cont’d) Workshop Workshop Workshop Workshop Room Genius 4 Parallel Session 7 Parallel Session 3 Room Medusa 4 (cont’d) Workshop Workshop Workshop Workshop Break Break Lunch Monday 1 Poster Session I 3 only) Break Break Room Lunch Genius Eutyches 3 (cont’d) Reception Workshop Workshop Workshop Workshop President’s President’s Auditorium (by invitation Tuesday 2 Tuesday Pecha Kucha I Parallel Session 6 Parallel Session 2 Poster Session II 2 Pecha Kucha II Eutyches 2 (cont’d) Workshop Workshop Workshop Workshop Auditorium August President Plenary I from ISBRfrom Auditorium Parallel Session 5 Parallel Session 1 Welcome AddressWelcome Plenary I (cont`d) 1 Room Galba 1 (cont’d) Workshop Workshop Workshop Workshop August Welcome Welcome Reception Auditorium August Sunday 31 (cont’d) Plenary II Plenary II Auditorium Time Time 09:00h 15:30h 16:00h 17:30h 18:30h 19:30h 20:30h 10:30h 11:00h 13:00h 14:00h 17:30h 18:30h 19:30h 20:30h 09:00h 11:00h 14:00h 10:30h 13:00h 15:30h 16:00h

10 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 11 Program overview Venue overview

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Break REGISTRATION

August A (cont’d) Plenary IV Plenary IV Auditorium Symposium Thursday 4

Closes (13:30h) ROO GENIUS

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Room A Genius Parallel Session 14 Parallel Session 10 A ROOM Break Break IP Lunch POTR ARA Social Dinner ROO ISIS Wednesday 3 Wednesday -1 ROO MINERVA AITORI ROO MEDUSA Eutyches

Auditorium EUTYCHES Parallel Session 9 Parallel Session 13

LN August (cont’d) ARA Plenary III Plenary III Auditorium -2 Parallel Session 8 Parallel Session 12 ROO GALBA

Time ROO TRAJÀ 10:30h 11:00h 09:00h 13:00h 14:00h 15:30h 16:00h 17:30h 18:30h 19:30h

12 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 13 Monday 1st April

09:00-09:40 WELCOME ADDRESS AUDITORIUM AUGUST

Welcome Address Ariel Alvarez, ISBR President

Application and Interest on Agricultural Biotechnology in Esther Esteban Rodrigo, INIA, Spain

09:40-13:00 PLENARY SESSION I AUDITORIUM AUGUST

PL I: COMMUNICATIONS AND ENGAGEMENT WITH POLICY AND PUBLIC AUDIENCES

Session Organizers: Hennie Groenewald, Biosafety South Africa, South Africa and Jennifer Anderson, Corteva Agriscience, USA

09:40-10:30 PL I - 1 KEYNOTE ADDRESS: Can Agriculture Save the Planet Before it Destroys it? Jack A. Bobo, Intrexon, Germantown, USA

11:00-11:30 PL I - 2 How Do You Want Agbiotech Science and Scientists to be Perceived? John Besley, Michigan State University, East Lansing, USA

TARRAGONA · 1st - 4th APRIL 15 Monday 1st April Monday 1st April

11:30-12:00 PL I - 3 Agribiotech Proponents: Guilty till Proven 14:00-15:30 PARALLEL SESSIONS Innocent. How Do We Get a Fair Chance? AUDITORIUM AUGUST Mahaletchumy Arujanan, Malaysian Biotechnology Information Centre (MABIC), Kuala Lumpur, Malaysia PS1: Scientific Assessment of the Food and Feed Safety of 12:00-12:30 PL I - 4 The Critical Role of C&E in a Developing Genetically Engineered Crops World, Biotech Policy Context Ben Durham, Bio-innovation Department of Science and Organizer: Jay S. Petrick, Bayer CropScience, USA Technology, Pretoria, South Africa 14:00-14:10 Opening Remarks 12:30-13:00 Moderated Panel Discussion 14:10-14:30 PS I - 1 Framework for Food Safety Assessment 13:00-14:00 Lunch of GM Crops: Codex and Historical Learnings Lisa Kelly, Food Standards Australia New Zealand, Canberra, Australia

14:30-14:50 PS I - 2 Compositional Assessment and Safety Assessment in the Light of Natural Variability Rod Herman, Corteva Agriscience, Indianapolis, USA

14:50-15:10 PS I - 3 Food and Feed Safety Assessment of Proteins Expressed in Genetically Engineered (GE) Crops Jay Petrick, Bayer Crop Science, Chesterfield, MO, USA

15:10-15:30 PS I - 4 Risk Assessment vs Precautionary Principle, Putting Hazard and Perception in their Proper Place for GE Crop Assessment Alison van Eenennaam, University of California-Davis, USA

16 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 17 Monday 1st April Monday 1st April

AUDITORIUM EUTYCHES GENIUS ROOM

PS2: New Breeding Technologies: Regulatory Hurdles PS3: Familiarity in the Context of Risk Assessment of for Existing Frameworks Transgenic Crops in the Americas

Organizers: Thorben Sprink, Julius Kühn-Institut, Organizers: Deise Capalbo, EMBRAPA Environment, Brazil and Detlef Bartsch, Federal Office of Consumer Protection and Carmen Vicièn, University of Buenos Aires, Argentina and Food Safety (BVL), Berlin, Germany 14:00-14:10 Opening Remarks 14:00-14:10 Opening Remarks 14:10-14:30 PS III - 2 Familiarity in the Context of Problem 14:10-14:30 PS II - 1 New Breeding Technologies: Regulatory Formulation Hurdles for Existing Frameworks Clara Rubinstein, Bayer Crop Science Argentina, Buenos Detlef Bartsch, Federal Office of Consumer Protection and Food Aires, Argentina Safety (BVL), Berlin, Germany 14:30-14:50 PS III - 3 The Use of Familiarity and a History of Safe 14:30-14:50 PS II - 2 The CJEU Ruling on New Techniques of Use in the Decisions of the Brazilian National Biosafety Technical Mutagenesis - A Broad Hint to EU Law Makers? Commission Georg Leggewie, Federal Office of Consumer Protection Patricia Fernandes, UFES, Vitoria, Brasil and Food Safety (BVL), Berlin, Germany 14:50-15:10 PS III - 4 The Regulation of Agricultural Biotechnology 14:50-15:10 PS II - 3 Current Situation of NPBTs Regulation in and Science: A Canadian Perspective on the Conceptual Tools for Latin America Problem Formulation Agustina Whelan, Biotechnology Directorate, State Secretariat Philip Macdonald, Canadian Food Inspection Agency, Ottawa, of Foodstuff and Bioeconomy, Buenos Aires, Argentina Canada 15:10-15:30 PS II - 4 The Recent Regulatory Framework of 15:10-15:30 PS III - 5 Case Study: Transportability of Virus Resistant Genome Editing Organisms and Foods in Japan Transgenic Common Bean- Field Studies from Brazil to Argentina Yutaka Tabei, Institute of Agrobiological Sciences, National Facundo Vesprini, Biotechnology Directorate of the Secretary Agriculture and Food Research Organization (NARO), Tsukuba, of Agroindustry, Buenos Aires, Argentina Japan

18 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 19 Monday 1st April Monday 1st April

MEDUSA ROOM 16:00-17:30 PARALLEL SESSIONS AUDITORIUM AUGUST PS4: Open Session 1 - Building Technical Capacity in Biosafety PS5: Science-based Allergenicity Risk Assessment for Food Chair: Wendy Craig, International Center for Genetic Engineering Derived from Genetically Engineered Crops and Biotechnology, Italy Organizer: Ping Song, Corteva Agriscience, USA 14:00-14:10 Opening Remarks 16:00-16:10 Opening Remarks 14:10-14:30 PS IV - 1 Measuring Effectiveness of Training Hector Quemada, Western Michigan University, Kalamazoo, 16:10-16:30 PS V - 1 Evaluating Potential Risks of Food Allergy Michigan, USA and Celiac Disease from Intended and Unintended Changes in Genetically Engineered Food Crops 14:30-14:50 PS IV - 2 The ICGEB eLearning portfolio: Key Richard Goodman, University of Nebraska-Lincoln, Lincoln, Outcomes and Lessons Learned NE, USA Wendy Craig, International Center for Genetic Engineering and Biotechnology, Trieste, Italy 16:30-16:50 PS V - 2 In vitro Gastro-intestinal Digestion Protocols for Allergenicity Assessment: Are More Physiological Conditions 14:50-15:10 PS IV - 3 Post-Release Monitoring: Pathway to Helpful in Separating Allergens from Non-allergens? Technology Sustainability in Africa Ronald Van Ree, Amsterdam University Medical Centers, Modupe Adeyemo, AUDA/NEPAD-ABNE, Dakar, Senegal Amsterdam, Holland

15:10-15:30 PS IV - 4 Strengthening Biosafety Compliance in 16:50-17:10 PS V - 3 Bioinformatic Evaluation of Newly Introduced Public Sector Research Institutions in India Proteins in GM Crops Vibha Ahuja, Biotech Consortium India Limited, New Delhi, Andre Silvanovich, Bayer Crop Science, St. Louis, MO, USA India 17:10-17:30 PS V - 4 Celiac Risk Assessment of Newly Expressed Proteins in GM Crops Using Bioinformatics, its Implications, Potential Issues, and Proposed Solutions Ping Song, Corteva Agriscience, Indianapolis, USA

20 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 21 Monday 1st April Monday 1st April

AUDITORIUM EUTYCHES GENIUS ROOM

PS6: Regulation and Sustainability: Enabling an Innovative PS7: Open Session 2 - Risk Assessment and New Technologies and Sustainable Bio-economy through a Harmonized Global Biosafety Framework for Industrial Biotechnology Chair: Andrew Roberts, ILSI Research Foundation, Washington DC, USA Organizer: Thiago Falda Leite, Brazilian Industrial Biotechnology Association, São Paulo, Brazil 16:00-16:18 PS VII - 1 Assessment of Risks for Human Health and the Environment of New Developments in Modern 16:00-16:10 Opening Remarks Biotechnology Boet Glandorf, National Institute of Public Health and the 16:10-16:30 PS VI - 1 The New Regulatory Framework Environment, Bilthoven, Holland of Genetically Modified Microorganism in Brazil: Impact to Industrial Biotechnology Development and its Consequences 16:18-16:36 PS VII - 2 Hazard Characterization and Risk to Environment Assessment Considerations for dsRNA Agricultural Products Maria Sueli Soares Felipe, CTNBio - Comissão Técnica Pamela M. Bachman, Jay Petrick, Bayer Crop Science, Chesterfield, Nacional de Biossegurança, Brasilia, Brasil MO, USA

16:30-16:50 PS VI - 2 Advances in Science and Biosafety to 16:36-16:54 PS VII - 3 EFSA’s Updated Explanatory Note on Build a Green Economy Literature Searching – Learning from Experience Patrick Rüdelsheim, Perseus BVBA, Sint-Martens-Latem, Belgium Yann Devos, European Food Safety Authority (EFSA), Parma, Italy

16:50-17:10 PS VI - 3 Combining Advances in Science and 16:54-17:12 PS VII - 4 Sublethal Endpoint Assessment for Biosafety - Impacts on the Market NTOs - Results from a Workshop on Non-Bt GE Plants Fred Wondergem, DuPont Industrial Biosciences, Leiden, Holland John Teem, ILSI Research Foundation, Washington DC, USA

17:10-17:30 Panel Discussion 17:12-17:30 PS VII - 5 Managing Adaptation of the Potato Late Blight Pathogen to Disease Resistance Genes Phillip Wharton, University of Idaho, Aberdeen Research & Extension Center, USA

22 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 23 Monday 1st April Monday 1st April

17:30-18:30 PECHA KUCHA I PK I - 9 Effects of mCry51Aa2-producing Cotton on the Non- AUDITORIUM EUTYCHES target Spider Mite Tetranychus urticae and the Predatory Bug Orius majusculus Kim Young-Joong, National Institute of Ecology, Seochon, South Korea PK I - 1 Comparative Evaluation of Bacterial Diversity from GM and Non-GM Maize Rhizosphere 18:30-19:30 POSTER SESSIONS I Naseer Ahmad, COMSATS University/IUE-CAS, Abbottabad, Pakistan P-01 Effects of Bt genetic engineering on induced volatile PK I - 2 Mutual Acceptance of Food and Feed Safety Assessments organic compounds in maize and host selection behavior of of Transgenic Crops: An Attainable Goal Trichogramma ostriniae Danilo Fernandez Ríos, Universidad Nacional de Asunción, Facultad Wang, Jianwu; Wang, Xiaoyi; Xv, Hao; Chi, Guoliang de Ciencias Exactas y Naturales, San Lorenzo, Paraguay P-02 Reassessment of exclusion zones of GM cotton in Brazil: PK I - 3 Introgression of cry1Ab into Open-Pollinated Maize and the case of Rondônia State its Effect on Cry Protein Expression Levels and Target Pest Survival Vianna Barroso, Paulo Augusto; De Paulo Campos Godinho, Reynardt Erasmus , North West University, Potchefstroom, South Vicente Africa P-03 Safety assessment of Bacillus thuringiensis insecticidal PK I - 5 Cross compatible transferability of ground nut microsatellite proteins Cry1C and Cry2A with a zebrafish embryotoxicity test primers (SSR) across with pearl millets and chickpea crops Gao, Yanjie; Zhu, Haojun; Chen, Yi; Li, Yunhe; Peng, Yufa; Sahu Vinod Kumar, College of Agriculture, RVSKVV, Gwalior, Chen, Xiuping Madhya Pradesh, Gwalior, India P-04 A genetic engineering approach to develop greening and PK I - 7 Exploring Porteresia coarctata (Roxb.) Tateoka, a Promising canker resistant citrus cultivars Salt-loving Plant for Developing Highly Salt Tolerant Rice Shohael, Abdullah; Omar, Ahmad; Grosser, Jude Habiba Most Umme, University of Dhaka, Bangladesh P-05 Evolution of very strong resistance to glyphosate in PK I - 8 Biosafety of Helicoverpa Resistant Transgenic Chickpea horseweed (Conyza canadensis), a major weed of Roundup Lines Expressing either a Cry1Ac or a Cry2Aa Gene Ready soybean fields in the USA Rubi Gupta, Assam Agricultural University, Jorhat, India Beres, Zachery; Snow, Allison; Owen, Micheal; Mackey, David; Giese, Laura; Loux, Mark

24 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 25 Monday 1st April Monday 1st April

P-06 Indirect, plant-mediated interactions between target P-15 Safety considerations for genome edited crops and non-target pests in Bt rice Hart, Hope Li, Yunhe; Meissle, Michael; Romeis, Jörg; Peng, Yufa P-16 Development of efficient information providing P-07 Evaluating potential risks of Bt rice straw as cultivation program for agricultural biotechnology base for earthworm Eisenia fetida Lee, Bumkyu Shu, Yinghua; Li, Junfei; Feng, Yuanjiao; Wang, Jianwu

P-08 The dynamics of a probable spread of cultivated algae P-17 Untargeted metabolic profiling of components in a Dattaroy, Tomal; Kaliyamoorthy, Kannadasan; Soni, Badrish; Teredesai, food chain of salt-tolerant transgenic plant and insects Aniket; Badami, Pranesh; Prasad, Venkatesh; Dasgupta, Santanu Nam, Kyong-Hee; Kim, Young-Joong; Kim, Ho Bang; Kim, Chang-Gi P-09 An exposure-based risk assessment system for GM plants Liu, Yongbo. P-18 Rice genome editing: a contribution to climate change mitigation and achievement of food security P-10 Testing the invasiveness of a transgenic cyanobacterium Gatica-Arias, Andres M; Rojas, Randall; Valdez-Melara, Marta; Dattaroy, Tomal; Kaliyamoorthy, Kannadasan; Soni, Badrish; Teredesai, Albertazzi-Castro, Federico; Hernández-Soto, Alejandro; Aniket; Badami, Pranesh; Prasad, Venkatesh; Dasgupta, Santanu Arrieta-Espinoza, Griselda P-11 Are genome edited products credence goods? Implications for regulation and governance P-19 Detection, identification and quantification of products Consmüller, Nicola; Bartsch, Detlef; Vaasen, Anja resulting from the use of new plant breeding techniques Sowa, Slawomir; Linkiewicz, Anna; Zimny, Janusz P-12 The Bt eggplant project in Bangladesh: present status, lessons learned and future prospects P-20 Monitoring and assessing the attack and injury level of Shelton, Anthony; Hossain, Jahangir; Paranjape, Vijay Ostrinia nubilalis (European corn borer) and Helicoverpa zea (corn earworm) on Bt and conventional maize P-13 Study of rice transgene flow Mihael Cristin, Ichim; Paula Paraschiva, Sosoi; Ancuta Cristina, Pei, Xinwu Raclariu; Elena Larisa, Tomescu; Madalina Oana, Popa; Andreea, Andrei; Ramona Elena, Irimia; Ramona Mihaela, P-14 Variability of nutritional component levels in maize Ciubotaru; Aliona, Rosca; Elena, Trotus; Diaconu, Alecu grain within individual hybrids is greater than the variability between a GE maize hybrid and its near-isogenic hybrid Brune, Philip; Fuquay, Leslie

26 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 27 Monday 1st April Monday 1st April

P-21 Development and evaluation of transgenic events PK I - 5 Cross compatible transferability of ground nut independently expressing cry1Ac, cry2Aa, cry1F and cry1A microsatellite primers (SSR) across with pearl millets and for managing pod borer (Helicoverpa armigera) in pigeon chickpea crops pea (Cajanu cajan) Sahu Vinod Kumar, College of Agriculture, RVSKVV, Gwalior, Bashasab, Fakrudin; Mahale Manohar, Barku; Philip Kavil, Siji; Madhya Pradesh, Gwalior, India Gowda, Vijayalakshmi; Mahabal, Neha PK I - 7 Exploring Porteresia coarctata (Roxb.) Tateoka, a P-22 Introgression of cry1Ac gene from transgenic chickpea into promising salt-loving plant for developing highly salt tolerant rice cultivated chickpea for pod borer resistance and identification Habiba Most Umme, University of Dhaka, Bangladesh of homozygous plants through marker assisted selection Kaur, Ajinder; Sharma, Urvashi; Singh, Sarvjeet; Singh, PK I - 8 Biosafety of Helicoverpa resistant transgenic Ravinder; Singh, Satnam; Sarmah, Bidyut Kumar chickpea lines expressing either a Cry1Ac or a Cry2Aa gene Rubi Gupta, Assam Agricultural University, Jorhat, India P-25 Agrobacterium-mediated genetic transformation in green gram (Vigna radiata L) for sustainable improvement PK I - 9 Effects of mCry51Aa2-producing cotton on the non- Rout, Gyana Ranjan; Swain, Dhaneswar target spider mite Tetranychus urticae and the predatory bug Orius majusculus PK I - 1 Comparative evaluation of bacterial diversity from Kim Young-Joong, National Institute of Ecology, Seochon, GM and non-GM maize rhizosphere South Korea Naseer Ahmad, COMSATS University/IUE-CAS, Abbottabad, Pakistan

PK I - 2 Mutual acceptance of food and feed safety assessments of transgenic crops: an attainable goal Danilo Fernandez Ríos, Universidad Nacional de Asunción, Facultad de Ciencias Exactas y Naturales, San Lorenzo, Paraguay

PK I - 3 Introgression of cry1Ab into open-pollinated maize and its effect on Cry protein expression levels and target pest survival Reynardt Erasmus , North West University, Potchefstroom, South Africa

28 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 29 Tuesday 2nd April Tuesday 2nd April

09:00-13:00 PLENARY SESSION II 12:05-12:35 PL II - 5 Argentine Practical Experience in the AUDITORIUM AUGUST Regulation of Gene-edited Products for Agroindustry Martin Lema, Biotechnology Directorate, Ministry of Production, Argentina PL II: ENVIRONMENTAL RISK ASSESSMENT AND REGULATION OF GENE EDITED PRODUCTS 12:35-13:00 Moderated Panel Discussion

Session Organizers: Heidi Mitchell, Office of the Gene Technology 13:00-14:00 Lunch Regulator, Australia and Joerg Romeis, Agroscope, Switzerland 14:00-17:30 WORKSHOPS (All workshops will run concurrently) 09:00-09:10 Opening Remarks GALBA ROOM 09:10-10:00 PL II - 1 KEYNOTE ADDRESS: Current Environmental Risk Assessment for Genetically Modified Organisms and Workshop 1. Gene Editing and Gene Drives for Managing Implications for Gene Edited Products. Unwanted Vertebrates - Current Status and Biosafety Jeffrey Wolt, Professor Emeritus of Agronomy at Iowa State University Considerations

10:00-10:30 PL II - 2 Precision Breeding for Improved Organizers: Allison Snow, Ohio State University, USA and Animal Health and Welfare Tim Harvey-Samuel, Pirbright Institute, UK Mitch Abrahamsen, Recombinetics Inc., USA 14.00-14:10 Introduction by workshop co-chairs 11:00-11:35 PL II - 3 Normative Criteria and their Inclusion in Allison Snow and Tim Harvey-Samuel a Regulatory Framework for New Plant Varieties Derived from Genome Editing 14:10-14:30 WS I - 1 Ecological Context for the Proposed Release David Hamburger, University of Passau, Faculty of Law, Passau, of Lyme- resistant, White-footed Mice: A Case Study of Gene Editing Germany. Allison Snow, Ohio State University, USA

11:35-12:05 PL II - 4 Problem Formulation and Phenotypic 14:30-14:50 WS I - 2 Determining the Feasibility of Gene Characterisation for the Development of Gene-edited Crops Drives for Feral Cat Control in Australia Alan Raybould, Syngenta Crop Protection AG, Basel, Switzerland Owain Edwards, CSIRO, Australia

30 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 31 Tuesday 2nd April Tuesday 2nd April

14:50-15:10 WS I - 3 A CRISPR-Cas9 Split Drive Targeting 14:15-14:30 WS II - 2 Benefits of Regulatory Streamlining Female Reproduction in Mice and Harmonization & Current Timeline Trends for Global GM Gus McFarlane, Roslin Institute, University of Edinburgh, UK Approvals Laurie Goodwin, CropLife International, Washington DC, USA 15:30-15:50 WS I - 4 Safe Development of CRISPR Gene Drives for Invasive Rodent Population Suppression 14:30-14:50 WS II - 3 Problem Formulation Approach to Paul Thomas, University of Adelaide, Australia Environmental Risk Assessments Jeff Wolt, Iowa State University, Ames, USA 15:50-16:10 WS I - 5 Engineering Genetic Incompatibility and Applications for Controlling Invasive Fish Populations 14:50-15:10 WS II - 4 Data Transportability: Overview, Key Michael Smanski, University of Minnesota, USA Concepts and Terms John Teem, ILSI Research Foundation, Washington DC, USA 16:10-16:30 WS I - 6 Principles of Probabilistic Risk Assessment for Genetic Biocontrol Keith Hayes, CSIRO, Australia 15:10-15:30 WS II - 5 Concept of Familiarity Clara Rubinstein, Bayer Crop Science, Buenos Aires, Argentina 16:30-17:25 Panel Discussion Chair: Tim Harvey-Samuel, Pirbright Institute, ; 16:00-16:40 WS II - 6 Global Alignment of Data Requirements Owain Edwards, CSIRO, Australia; Neil Gemmel, Univ. Otago, for Risk Assessments New Zeland and Keith Hayes, CSIRO, Australia Angela Culler, Bayer Crop Science, USA, Jen Anderson, Corteva AgriScience, Johnston, IA, USA AUDITORIUM EUTYCHES 16:40-17:30 Panel Discussion - Q&A with Regulators Workshop 2. Benefits and Strategies for Global Regulatory Panellists: Karen Hokanson, Heidi Mitchell, Ryo Ohsawa, Martin Data Streamlining, Harmonization, and Collaboration Lema, Le Huy Ham, Maria Sueli Felipe Soares (to be confirmed)

Organizer: Laurie Goodwin, CropLife International, Washington DC, USA

14:00-14:15 WS II - 1 Introductory Remarks Karen Hokanson, Department of Horticultural Science, University of Minnesota, Minneapolis, USA

32 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 33 Tuesday 2nd April Tuesday 2nd April

GENIUS ROOM 14:25-14:40 WS IV - 3 Communication & Engagement for Policy and Regulation Development Workshop 3. Crop Composition as a Component of Food Sam Timpo, African Biosafety Network of Expertise, Senegal and Feed Safety Assessment and Hands on with the ILSI Crop Composition Database 14:40-14:55 WS IV - 4 Communication & Engagement that Moves People to Action Organizers: Andrew Roberts and Bhavneet Bajaj, ILSI Sarah Evanega, Cornell Alliance for Science, Cornell University, USA Research Foundation, USA 14:55-15:10 WS IV - 5 Communication & Engagement This workshop will be given twice: Results - Monitoring & Evaluation 14:00-15:45 Hennie Groenewald, Biosafety South Africa, South Africa 16:00-17:45 15:10-15:25 WS IV - 6 Embracing Nature: Communication & This is a hands-on, practical workshop where participants will be Engagement in Plant Breeding Innovation, from Lab to Fork using the CCDB. Attendees are encouraged to bring their laptops . Petra Jorasch, European Seed Association, Belgium

MEDUSA ROOM 16:00-16:15 WS IV - 7 Science of Science Communications: Perspectives on the Practice of Communications and Engagement Workshop 4. Real-world Biosafety Communication and John Besley, Michigan State University, USA Engagement 16:15-17:20 Panel Discussion on Common Approaches Organizers: Jill Kuehnert, Seed Stories, USA and Hennie and Areas of differentiation Groenewald, Biosafety SouthAfrica, South Africa Audience participation

14:00-14:10 WS IV - 1 Introduction & Goals: Real-world Biosafety Communication & Engagement 17:20-17:30 Wrap-up and Conclusion Hennie Groenewald, Biosafety South Africa, South Africa Jill Kuehnert, Seed Stories, USA

14:10-14:25 WS IV - 2 Communication & Engagement as an Integrated Aspect of R&D Projects Jill Kuehnert, Seed Stories, USA

34 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 35 Tuesday 2nd April Tuesday 2nd April

MINERVA ROOM 15:00-16:00 Session 2 - The Haves and Have-Nots: Equalizing Farmer Access to crop Biotech Innovations Workshop 5. Access to Crop Biotech Innovations: Exchange and Learnings from GM Cultivation in the EU, Chair: Patricia Nanteza, Alliance for Science, Uganda South Asia, and Africa > The Impact of Access in South Africa Organizers: Sarah Davidson Evanega, Cornell Alliance for Molatsi Musi, Farmer, South Africa Science; Coen Frederiks and Petra Kostolaniova, The European Association for Bio-Industries (EuropaBio) > Demanding Access to Innovations to Beat Fall Armyworm Patience Koku, Replenish Farms, Nigeria 14:00-15:00 Session 1 - GM Cultivation in Spain > The Benefits of Bt Eggplant in Bangladesh Chair: Esther Esteban Rodrigo, INIA, Spain Md. Milon Mla, Bangladesh

> Experience of a Farmer Cultivating Bt Maize > Lost Opportunity in India? José Luis Romeo, Bt maize grower and AGPME President M.T. Narain, India

> Monitoring Programs: Lessons from Implementation in Spain > Engaging Youth in Agriculture Through Access to Ag Innovations Felix Ortego, CIB-CSIC Evans Okomeng, Millennium Farms, Ghana

> Environmental Benefits of Bt Maize Cultivation in Spain > Roundtable Discussion with Farmers Francisco Areal, Reading University, UK 16:00-16:30 Session 3 - The Africa & the EU Biotech Relationship > Roundtable Discussion Moderated by Esther Esteban Rodrigo Chair: Patrick Rudelsheim, Perseus BVBA, Sint-Martens-Latem, Belgium

Moderated discussion with Molatsi Musi, Patience Koku, Esther Esteban Rodrigo, Francisco Areal and Patricia Nanteza

36 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 37 Tuesday 2nd April Tuesday 2nd April

ISIS ROOM WS VI - 5 Authorisation of Sprayable RNAi Based Plant Protection Products: Challenges for Environmental Risk Workshop 6. Biosafety of RNAi Applications for Plant Protection Assessment and Risk Management Achim Gathmann, Federal Office for Consumer Production Organizers: Salvatore Arpaia, Italian National Agency for New and Food Safety, Bruanschweig, Germany Technologies, Energy and Sustainable Economic Development (ENEA), Italy, Antje Dietz-Pfeilstetter, Julius Kühn-Institute, Germany WS VI - 6 Silencing an Essential Gene Involved in Infestation and Jeremy Sweet, JTEC Ltd., UK and Digestion in Grain Aphid through Plant-mediated RNA Interference Generates Aphid-resistant Wheat Plants WS VI - 1 A Review of Baseline Information on RNAi that Supports Huw Jones, Institute of Biological, Environmental & Rural the Environmental Risk Assessment of some RNAi-based GM Plants Sciences (IBERS), Aberystwyth University, UK Jeremy Sweet, JT Environmental Consultants Ltd, Cambridge, UK WS VI - 7 Problem Formulation in the ERA of RNAi-based WS VI - 2 Phage-based Bacterial Production and Exogenous GM Wheat with Resistance to Fusarium Pathogens Application of dsRNAs for Plant Protection Felix Moronta-Barrios, Biosafety Group, International Centre Annette Niehl, Julius Kühn-Institut (JKI), Institute for Epidemiology for Genetic Engineering and Biotechnology (ICGEB), Trieste, and Pathogen Diagnostics, Braunschweig, Germany Italy

WS VI - 3 Viral-based dsRNA Delivery Systems for Use in Pest WS VI - 8 Data Requirements for the Environmental Assessment and Disease Control of RNAi plants: Introduction to a Discussion Olivier Christiaens, Ghent University, Ghent, Belgium Antje Dietz-Pfeilstetter, Julius Kühn-Institut (JKI), Institute for Epidemiology and Pathogen Diagnostics, Braunschweig, WS VI - 4 Problem Formulation for Environmental Risk Germany Assessment of Spray Applications of Insecticides Containing Double-stranded RNA Alan Raybould, Syngenta Crop Protection AG, Basel, Switzerland

38 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 39 Tuesday 2nd April Tuesday 2nd April

17:30-18:30 PECHA KUCHA II PK II - 6 Socioeconomic Considerations - A Benefit or AUDITORIUM EUTYCHES Hindrance to Advancing Agricultural Biotechnology D. Hashini Galhena Dissanayake, College of Agrculture and Natural Resources, Michigan State University, East Lansing, USA PK II - 1 Public Perceptions of Bt Brinjal in Bangladesh Sium Ahmed, Department of Biotechnology and Genetic PK II - 7 A Critical Review of the Namibian Biosafety Regulations Engineering, Jahangirnagar University, Savar, Bangladesh and their Implication on Processed Food Importers Paulus Mungeyi, National Commission on Research Science PK II - 2 Prospective Biosafety Evaluation Regarding Genetic and Technology (NCRST), Windhoek, Namibia Modified Cultivars of Sugarcane: Gene Flow Assessment and Nutritional Composition PK II - 8 Pea p68, a DEAD-box helicase, enhances salt Eduardo de Andrade Bressan, Luiz de Queiroz Agriculture tolerance in marker-free transgenic soybean College, University of São Paulo (USP), Piracicaba, SP, Brazil Sivabalan Karthik, School of Biotechnology and Genetic Engineering, Department of Biotechnology, Bharathidasan PK II - 3 Inter-species Sensitivity Variation of Non-target University, Tiruchirappalli, India Lepidoptera Affects Risk Assessment of Bt Maize Marina Lee, Agrotecnio Center, Department of Plant Production PK II - 9 Effect of Busseola fusca on Cry1Ab Protein Expression and Forestry Science, University of Lleida, Lleida, Spain Levels in Bt Maize Plants and Bt Maize Crosses Reynardt Erasmus , North West University, Potchefstroom, PK II - 4 Variations in Resistance to the Diamondback Moth South Africa of Feral Brassica napus Growing Around the Ports in Japan Erina Yanagi, Graduate School of Life and Environmental 18:30-19:30 POSTER SESSIONS II Sciences, University of Tsukuba, Ibaraki, Japan P-23 Evaluation of whole genome sequencing and an insertion PK II - 5 Characterization of CP4-EPSPS, Cry1Ac and Cry2Ab site characterization method for molecular characterization of Genes Pyramid Transformed in to Tobacco Plants GM maize Muhammad Imran, Agricultural Biotechnology Division, Cade, Rebecca; Hart, Hope National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan P-24 Comparison of sequencing methods for the molecular characterization of genetically-modified crops Cade, Rebecca; Hart, Hope

40 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 41 Tuesday 2nd April Tuesday 2nd April

P-26 Hybridization between maize (Zea mays) and teosinte Z. P-33 Current and future contributions to the work of the Cartagena mays ssp. mexicana and Z. mays ssp. parviglumis Protocol on Biosafety (BSP) by the Global Industry Coalition Loureiro, Iñigo; Escorial, Concepción; Chueca, Cristina Lukie, Sarah; Atanassova, Ana

P-27 Studies on root nodulation and associated bacterial P-34 Genetically modified insect-protected maize cultivation community structure in insect resistant (IR) transgenic in the EU: the MON 810 case chickpea (Cicer arietinum L.) Fernández Cantón, Rocío; Bertho, Lieselot; Brants, Ivo Das, Alok; S, Shilpa; A, Harika; Singh, N P; M, Senthilkumar P-35 Socioeconomic impacts of the gene editing regulation P-28 Characterization of Bt Vip3Aa protein for GMO risk in Argentina: preliminary statistics assessment Whelan, Agustina; Gutti, Patricia; Lema, Martin Yoo, Su-Hyang; Jung, Young Jun P-37 Safety evaluation and approval status of genetically modified foods in Korea P-29 Intensified and sustainable agriculture in developing countries: Myung-Sang Yoo, In-Sun Joo, Ji-Eun Shin, Mi-Ran Jang, Su-Eun opportunities for, and role of, DNA-based crop improvement Lee, Ji-Yeon Kwak, Ji-Sun Park, Bo-Ram Yi and Jong-Seok Park Huttner, Eric P-38 Asia forum: An information exchange initiative by Korea BCH P-30 Fall armyworm and genetically modified maize: an effective Jang, Homin insect resistance management programme requires tight integration of pre-marketing research and post-marketing monitoring P-39 Positive impacts of the new Brazilian regulatory scenario Bouwer, Gustav for commercialization of genetically modified microorganisms and their derivatives: Amyris case P-31 Current applications of genome editing in agriculture: Seligman, Kelly; Curzio, Bianca a systematic map Wilhelm, Ralf; Modrzejewski, Dominik; Krause, Doerthe; P-40 The concept of pure and chemically defined substances Hartung, Frank; Sprink, Thorben; Kohl, Christian and implications for their risk assessment Gianotto, Adriana; Seligman, Kelly; Falda, Thiago P-32 Capacity building for regulatory compliance and product stewardship for commercialization and deployment P-41 Argentinian expertise in regulatory cooperation of GM crops in Africa Goberna, Florencia; Glorio, Maria Del Lucero; Whelan, Mbabazi, Ruth Agustina

42 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 43 Tuesday 2nd April Tuesday 2nd April

P-42 Prospective strategy of communication for biotechnology P-50 Towards developing science based regulation on in Argentina genome editing in India Glorio, Maria Del Lucero; Goberna, Florencia; Whelan, Agustina Agarwal, Sangeeta; Reddy, Vanga Siva; Rao, S Raghavendra

P-43 Determinants of attitude and perceptions towards P-51 Concept of familiarity in risk assessment - experience of GMOs and biosafety policy in Uganda the Americas Zawedde, Barbara Mugwanya; Mugwanya, Nassib; Oloka, Deise M. F. Capalbo Herbert; Makara, Arthur Musinguzzih PK II - 1 Public perceptions of Bt brinjal in Bangladesh Sium Ahmed, Department of Biotechnology and Genetic P-44 Evolution of the environmental risk assessment of stack Engineering, Jahangirnagar University, Savar, Bangladesh GM crops in Argentina Muhl, Marina; Whelan, Agustina; Vesprini, Facundo PK II - 2 Prospective biosafety evaluation regarding genetic modified cultivars of sugarcane: gene flow assessment and P-46 The regulation of GMOs in New Zealand nutritional composition Strabala, Timothy Eduardo de Andrade Bressan, Luiz de Queiroz Agriculture College, University of São Paulo (USP), Piracicaba, SP, Brazil P-47 A simple problem formulation framework to create the right solution to the right problem PK II - 3 Inter-species sensitivity variation of non-target Sauve, Alaina; Davis, Kathryn; Mcdonald, Justin; Ramanarayanan, Lepidoptera affects risk assessment of Bt maize Tharacad; Raybould, Alan; Wolf, Doug; Valenti, Ted Marina Lee, Agrotecnio Center, Department of Plant Production and Forestry Science, University of Lleida, Lleida, Spain P-48 Assessment of effects from Bt maize on non-target PK II - 4 Variations in resistance to the diamondback moth of Lepidoptera: towards improvement of test protocols and feral Brassica napus growing around the ports in Japan risk assessment Erina Yanagi, Graduate School of Life and Environmental Lee, Marina Stella; Berchtold, Julitta; Dolek, Matthias; Otto, Sciences, University of Tsukuba, Ibaraki, Japan Mathias; Lang, Andreas PK II - 5 Characterization of CP4-EPSPS, Cry1Ac and Cry2Ab P-49 Biosafety status and socioeconomic effects of Bt- brinjal genes pyramid transformed in to tobacco plants cultivation and its public perception in Bangladesh Muhammad Imran, Agricultural Biotechnology Division, Shahidul Haque, Muhammad; Ranjan Saha, Nihar; Solaiman, National Institute for Biotechnology and Genetic Engineering, Mohammed Faisalabad, Pakistan

44 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 45 Tuesday 2nd April

PK II - 6 Socioeconomic considerations - a benefit or hindrance to advancing agricultural biotechnology D. Hashini Galhena Dissanayake, College of Agriculture and Natural Resources, Michigan State University, East Lansing, USA

PK II - 7 A critical review of the Namibian biosafety regulations and their implication on processed food importers Paulus Mungeyi, National Commission on Research Science and Technology (NCRST), Windhoek, Namibia

PK II - 8 Pea p68, a DEAD-box helicase, enhances salt tolerance in marker-free transgenic soybean Sivabalan Karthik, School of Biotechnology and Genetic Engineering, Department of Biotechnology, Bharathidasan University, Tiruchirappalli, India ANUNCIO PK II - 9 Effect of Busseola fusca on Cry1Ab protein expression levels in Bt maize plants and Bt maize crosses Reynardt Erasmus, North West University, Potchefstroom, South Africa

19:30 PRESIDENT'S RECEPTION (MEMBERS ONLY) GENIUS ROOM

46 15th ISBR Symposium 2019 Wednesday 3rd April Wednesday 3rd April

09:00-13:00 PLENARY SESSION III 14:00-15:30 PARALLEL SESSIONS AUDITORIUM AUGUST AUDITORIUM AUGUST

PL III: FOOD SAFETY ASSESSMENT OF NOVEL MOLECULES– WHAT DOES THE FUTURE HOLD? PS8: Targeted Crop Improvement: Genome Editing in the Plant Breeder’s Tool Box Session Organizers: Vibha Ahuja, Biotech Consortium India Limited, India and Joe Smith, ISBR President Elect, Australia Organizers: John McMurdy, CropLife International, USA and 09:00-09:10 Opening Remarks Alessandra Salamini, Bayer CropScience, USA

09:10-10:00 PL III - 1 KEYNOTE ADDRESS: Innovation, Equity 14:00-14:10 Opening Remarks and Rates of Change Rob Horsch, Deputy Director, Agricultural Development (retired) 14:10-14:30 PS VIII - 1 Gene Editing 101: The Basics about Bill & Melinda Gates Foundation, USA Genome Editing Tools 10:00-10:30 PL III - 2 Dispatches from the Frontier of Fact and Huw Jones, IBERS Aberystwyth University, Aberystwyth, UK Fiction: The Past, Present and Future of Dietary RNA Studies Kenneth Witwer, Johns Hopkins University School of Medicine, USA 14:30-14:50 PS VIII - 2 Reflections on the UK’s First Field 11:00-11:35 PL III - 3 Plant and Animal Genome Editing Trial of Gene-edited Plants and the Impact of the ECJ Using CRISPR/Cas9 Ruling on European Plant Sciences Okaje Koo, ToolGen Inc., Republic of Korea Johnathan Napier, Rothamsted Research, Harpenden, UK

11:35-12:05 PL III - 4 Development and Deregulation of 14:50-15:10 PS VIII - 3 PS VIII - 3 Bringing Consumer- DHA-Canola - A Novel and Sustainable Source of Essential Omega-3 Fatty Acids focused Products to Market Allan Green, CSIRO Agriculture & Food, Australia Chloe Pavely, Calyxt Roseville, MN, USA

12:05-12:35 PL III - 5 Paradigms for the Interaction of 15:10-15:30 PS VIII - 4 The Need for Consistent Genome Nanoscale Objects with Living Organisms Editing Policies Globally to Foster Innovation in Agriculture Kenneth Dawson, University College Dublin, Ireland Detlef Bartsch, Federal Office of Consumer Protection and 12:35-13:00 Moderated Panel Discussion Food Safety (BVL), Berlin, Germany 13:00-14:00 Lunch

48 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 49 Wednesday 3rd April Wednesday 3rd April

AUDITORIUM EUTYCHES GENIUS ROOM

PS9: Risk Assessment and Management of Gene Drive Research PS10: Fall Armyworm IPM in Africa and Asia - The Challenge of Creating An Enabling Environment for Organizer: Fabio Niespolo, Outreach Network for Gene Drive Knowledge, Policy And Tools Research Chair: Joe Huesing and Regina Eddy, United States Agency for Chair: Delphine Thizy, Target Malaria, Imperial College London, UK International Development, Washington DC, USA

14:00-14:10 Opening Remarks 14:00-14:10 Opening Remarks

14:10-14:30 PS IX - 1 Safeguarding Gene Drive Research: 14:10-14:30 PS X - 1 The Fall Armyworm in Africa and Asia - Measures to Support Responsible Research Using Gene Drives Lessons on Controlling an Invasive Pest in the Developing World J. Royden Saah, GBIRd/Island Conservation, Raleigh, USA Joe Huesing, United States. Agency for International Development, Washington DC, USA 14:30-14:50 PS IX - 2 Building an Evaluation Pathway to Assess Gene Drive Technology for Malaria Control 14:30-14:50 PS X - 2 Risk Considerations in Technology Hector Quemada, Western Michigan University, Kalamazoo, Selection for FAW and Other Invasive Pests Michigan, USA Paul Jepson, College of Agricultural Sciences, Oregon State University, Corvallis, USA 14:50-15:10 PS IX - 3 Ethical Considerations Raised by Synthetic Gene Drive Research 14:50-15:10 PS X - 3 Fall Armyworm Spodoptera frugiperda Aaron Roberts; Claudia Emerson, Institute on Ethics and Policy in Asia, an Update from Thailand for Innovation, McMaster University, Hamilton, Canada Mao Chen, Bayer Crop Science, Singapore

15:10-15:30 PS IX - 4 Perspectives from a Regulator on 15:10-15:30 PS X - 4 Aligning Policy and Science for Effective Biosafety Assessment of Products Containing Gene Drives Regulatory Decision-making Martin Lema, Biotechnology Directorate, Ministry of Production, Alan Raybould, Syngenta Crop Protection AG, Basel, Switzerland Buenos Aires, Argentina

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Wednesday 3rd April Wednesday 3rd April

MEDUSA ROOM 16:00-17:30 PARALLEL SESSIONS AUDITORIUM AUGUST PS11: Open Session 3 - A Medley of Biosafety Risk Assessment and Regulation Topics PS12: Developing Innovative Genetic Technologies for Malaria Control: Risk Assessment and Stakeholder Engagement for Chair: Pamela Bachman, Bayer Crop Science, USA Field Testing

14:00-14:18 PS XI - 1 Gene Drives in the Environment – Facts and Experience to Inform Risk Assessment Organizer: Delphine Thizy, Target Malaria, Imperial College Patrick Rudelsheim, Perseus BVBA, Sint-Martens-Latem, Belgium London, UK

14:18-14:36 PS XI - 2 The First Field Release of a Genetically 16:00-16:10 Opening Remarks Engineered, Self-limiting Insect in North America and its Potential for Pest Management 16:10-16:30 PS XII - 1 Introduction to Target Malaria: Co- Anthony Shelton, Cornell University, US development for Success Delphine Thizy, Target Malaria, Imperial College London, UK 14:36-14:54 PS XI - 3 Advances in Genetic Modification Techniques and Challenges in Detection of GMOs on a 16:30-16:50 PS XII - 2 The Importance of Preparedness – Plans Regulatory Perspective and Steps for Innovation in the Field of Genetic Technologies John Lijo, Export Inspection Agency, Kochi, India for Malaria Control Charles Guissou, Institut de Recherche en Sciences de la 14:54-15:12 PS XI - 4 Assessing the Risk of Resistance Santé, Bobo Dioulasso, Burkina Faso Development of the Target Pest Sesamia nonagrioides to Bt Maize in the EU 16:50-17:10 PS XII - 3 Pathway to Deployment of Gene Drive Ana Martin Camargo, European Food Safety Authority, Parma, Mosquitoes as a Potential Biocontrol Tool for Elimination of Italy Malaria in Sub-Saharan Africa Brinda Dass, Foundation for the National Institutes of 15:12-15:30 PS XI - 5 Regulation of Genetically Modified Health, Bethesda, USA Organisms and New Breeding Technologies: Brazilian Experience Rubens José Nascimento, National Biosafety Technical Commission, Brasília, Brasil 17:10-17:30 PS XII - 4 Mapping Inputs and Evidence to Support Regulatory Decision Making for Target Malaria Gene Drive Strategies Geoff Turner, Imperial College London, UK

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AUDITORIUM EUTYCHES GENIUS ROOM

PS13: Opportunities and Challenges in Public Sector PS14: Biosafety Considerations for the Use of Genetic Variation Biotechnology Crop Improvement in Plant Breeding

Organizer: Donald MacKenzie, Institute for International Crop Organizer: Maria Fedorova, Corteva Agriscience, USA Improvement, Donald Danforth Plant Science Center, St. Louis, USA 16:00-16:10 Opening Remarks 16:00-16:10 Opening Remarks 16:10-16:30 PS XIV - 1 Sources and Uses of Genetic Variation 16:10-16:30 PS XIII - 1 Uncertain Regulatory and Policy in Conventional Plant Breeding: Spontaneous Mutations, Environments. Lessons from the Virus Resistant Cassava for Untargeted Induced Mutagenesis, and Tissue Culture Africa Plus (VIRCA Plus) Project in Kenya and Uganda Robert Stupar, University of Minnesota, Saint Paul, USA Andrew Kiggundu, Donald Danforth Plant Science Center, St. Louis, USA 16:30-16:50 PS XIV - 2 Comparison in Mutation Frequency Among Wild Types, Tissue Cultured Mutants, Genome- 16:30-16:50 PS XIII - 2 Public Sector Efforts on Agricultural edited Mutants, and Transgenic Lines in Rice Biotechnology Development – Case of PBR Cowpea in Africa Mai Tsuda, University of Tsukuba, Japan Onyekachi Francis, African Agricultural Technology Foundation (AATF) Nairobi, Kenya 16:50-17:10 PS XIV - 3 Evaluation of S. pyogenes Cas9 Specificity in Maize Genome Editing and its Relevance in 16:50-17:10 PS XIII - 3 Recent Advances on Research and Crop Improvement Development of Golden Rice in Bangladesh Sandeep Kumar, Corteva Agrisciences, Johnston, USA Partha S. Biswas, International Rice Research Institute., Gazipur, Bangladesh 17:10-17:30 Moderated Panel Discussion

17:10-17:30 Moderated Panel Discussion

56 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 57 Wednesday 3rd April Thursday 4th April

MEDUSA ROOM 09:00-13:30 PLENARY SESSION IV AUDITORIUM AUGUST PS15 Open Session 4 - Experiences with Communication and Stakeholder Engagement PL IV: CHALLENGES IN THE DEVELOPMENT AND ADOPTION Chair: Gabriela Levitus, ArgenBio, Argentina OF NOVEL BIOTECHNOLOGIES

16:00-16:20 PS XV - 2 The Alliance for Science: Partnering for Impact Session Organizers: Carmen Vicién, University of Buenos Aires, Sarah Evanega, Cornell University, Ithaca, USA Argentina and Camilla Beech, Cambea Consulting Ltd, UK

16:20-16:40 PS XV - 3 Challenges and Achievements 09:00-10:00 PL IV - 1 KEYNOTE ADDRESS: Enabling Innovation Communicating the Safety of GMOs in Agricultural Breeding Programs: Promises and Prospects Maria Luz Zapiola, ArgenBio, Argentina Alison Van Eenennaam, University of California-Davis, USA

16:40-17:00 PS XV - 4 Safeguarding Africa’s Interest in Ongoing 10:00-10:30 PL IV - 2 Establishing a Community of Practice International Negotiations on Regulating Emerging Technologies Around Public Sector Product Development Samuel Timpo, African Biosafety Network of Expertise, Dakar, Donald MacKenzie, Donald Danforth Plant Science Center, St. Senegal Louis, USA

17:00-17:20 PS XV - 5 Food Innovation Dialogue: How Gene 11:00-11:35 PL IV - 3 Local Developments: Why Have They Not Editing Could Benefit from the GMO Experience Reached the Market Yet? Adriana Brondani, CIB - Council for Information on Biotechnology, Dalia Marcela Lewi, Instituto Nacional de Tecnología Agropecuaria, São Paulo, Brasil Argentina

17:20-17:30 Moderated Panel Discussion 11:35-12:05 PL IV - 4 Abiotic Stress (Drought) Tolerant Transgenic Wheat 19:30 SOCIAL DINNER at Masia Boella Patricia V. Miranda, Instituto de Agrobiotecnologia Rosario, Bus service from the VENUE Argentina

58 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 59 th Thursday 4 April A HEALTHY WORLD NEEDS 12:05-12:35 PL IV - 5 What Dialogue is Needed? The Example HEALTHY FOOD. of Engagement for Innovative Genetic Approaches to Malaria Elimination We’re transforming the future of agriculture with science and technology to grow healthier food Delphine Thizy, Target Malaria, Imperial College, UK for everyone. Learn more at Corteva.com 12:35-13:00 Moderated Panel Discussion KEEP GROWING.

13:00-13:30 Closing remarks from Joe Smith, ISBR President

13:30 SYMPOSIUM CLOSES AUDITORIUM AUGUST TM ,®, SM Trademarks and service marks of Dow AgroSciences, DuPont or Pioneer, and their affiliated companies or their respective owners. © 2019 PHII. © 2019 owners. respective or their companies affiliated and their or Pioneer, DuPont AgroSciences, Dow of marks and service Trademarks TM ,®, SM

60 15th ISBR Symposium 2019 General information General information

ABOUT TARRAGONA ACCESS/SECURITY

Located on the Mediterranean, in the heart of the Costa Name badges will be provided to all delegates and Daurada, Tarragona is Catalonia’s southernmost capital city, participants when they check in at the Registration Desk. less than 100 kilometres away from Barcelona. Bathed by The badge is your admission pass to all conference sessions, the Mediterranean, Tarragona boasts stunning beaches and the exhibit hall and social events. Delegates are required to mild climate all year round. wear their name badge at all times and will not be granted access to the Conference without it. This is to ensure that access to the Conference is properly managed.

CURRENCY & BANK/ATM

The currency in Tarragona is the Euro (€). Most of the hotels, restaurants and stores accept credit cards, such as Visa and MasterCard, along with travelers’ cheques. “Cajeros Automaticos” (ATMs) are in all the major hotels and outside banks. Foreign currency can be exchanged at savings banks.

INTERNATIONAL TIME ZONE From 27 to 25 BC, Tarragona was home to Emperor Augustus, and the city has inherited much from its past. The time in Spain is CET (Central European Time) which is The declaration of Tarragona as World Heritage City by GMT + 1 hour. UNESCO is proof of this legacy. Monuments, location and climate make Tarragona an exceptional destination, one SYMPOSIUM DATES AND VENUE where visitors can play golf or tennis, go horseback riding or sailing ... activities that can also be combined with the city’s 1/4 April 2019 varied shopping and culinary offer.All of these attractions are Palacio de Congresos de Tarragona joined by easy access to and from the city and all together Arquitecte Rovira, 2 – 43001 Tarragona make Tarragona an ideal destination to combine culture, http://www.palautarragona.com/en/ tourism and entertainment with any type of event in a modern, urban setting.

62 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 63 General information

SYMPOSIUM MOBILE APP & SOCIAL MEDIA

The official 15th ISBR Symposium Mobile App can be installed by visiting https://app.isbr2019.com: a pop-up will come up with instructions about how to download it in your device.

Don’t forget to follow us on Twitter, Facebook, and Flikr for the Photo Competition:

www.twitter.com/ISBR2019

www.facebook.com/ISBR2019

www.flickr.com/groups/4536248@N21/pool/ with/43647643561/ SYMPOSIUM LANGUAGE Our roots The language spoken in Tarragona is Spanish and Catalan. The official language of the Symposium is English. All sessions will be conducted in English. Simultaneous run deep translation will not be provided. Chances are, you’ve seen us around the house, or around the yard. In the store, or even out in the field. In fact, families and farmers have turned to Bayer for six generations and counting. SYMPOSIUM SECRETARIAT Because for over 150 years, we’ve been right by your side. Advancing the health of the people, plants and pets you love. Thank you for trusting us, then and now. Maria Cubi, 4 – Pral. Bayer.com @Bayer Bayerofficial 08006 Barcelona (SPAIN) Tel. +34 932 388 777 / [email protected]

64 15th ISBR Symposium 2019 General information General information

SYMPOSIUM WI-FI SPEAKER PREP ROOM

There will be wi-fi available for all attendees, the net will be The conference will have a speakers’ preview room in Room open, no password required. Tarraco (0 floor)where speakers can test their presentation beforehand and upload the file onto the laptop, in the same ELECTRICITY Prep room, so that they can have it ready for their session. Speakers are invited to upload their presentation at least 3 Electricity supply is 220 volts throughout Spain with two pin hours prior to the beginning of their session. wall sockets. For any European countries that use 240 volts, No personal laptops can be used. e.g. UK and Ireland most electrical equipment will function Please note that all rooms will be equipped with the following: adequately. a microphone, projector, screen and PC computer (with MS PowerPoint). MEDICAL ASSISTANCE & INSURANCE TAXES Emergency phone: 112 Value-Added Tax is called IVA (for Impuesto sobre el valor Participants are advised to make their own arrangements añadido) in Spain. It is levied on services, such as hotels and regarding travel insurance and medical assistance during restaurants, and on consumer products. the Congress. Neither the Organization nor the Secretariat are able to accept any responsibility whatsoever for damage The IVA rate for hotels and restaurants is 10%. Menus will or injury to persons or their belongings during the Congress. generally say at the bottom whether tax is included (IVA incluido) or not. While food and basic necessities are taxed REGISTRATION DESK at the lowest rate, most consumer goods are taxed at 21%. TELEPHONE SERVICE The registration desk is located in the 1st Floor and will be open at the following times: General emergencies: 122 Sunday March 31: from 17:30h to 20:30h CatSalut (Medical emergencies): 061 Monday April 1: from 08:00h to 18:00h Fire Service: 080 Tuesday April 2: from 08:30h to 18:30h Guàrdia Urbana (Local ): 092 Wednesday April 3: from 08:30h to 17:30h Mossos d’Esquadra (Catalan Police Force): 112 Thursday April 4: form 08:30h to 13:00h Policia Nacional (National Police): 091

66 15th ISBR Symposium 2019 TARRAGONA · 1st - 4th APRIL 67 General information Notes

DISCLAIMER

All reasonable endeavors will be made to hold the 15th ISBR Symposium and to present the printed program as scheduled under circumstances which assure the comfort and safety of the Symposium Participants. However, the ISBR and its Regions, the 15th ISBR Organizing Committee, and their representative directors, officers, employees, representatives or agents, shall not be liable in any manner whatsoever to any person as a result of the cancellation of the Symposium or any of the arrangements, programs or events connected therewith; nor shall any of the foregoing entities or persons be liable in any manner whatsoever for any loss, injury, damage or inconvenience which may be suffered by any person’s presence in Spain in connection with the Symposium. Participants are advised to consider procuring their own insurance against any such occurrences.

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SYMPOSIUM