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Recommended INN: List 46 WHO Drug Information, Vol 15, No 3-4, 2001 Recommended INN: List 46 International Nonproprietary Names for Pharmaceutical Substances (INN) RECOMMENDED International Nonproprietary Names (Rec INN): List 46 Notice is hereby given that, in accordance with paragraph 7 of the Procedure for the Selection of Recommended International Nonproprietary Names for Pharmaceutical Substances [Off Rec Wld Health Org, 1955, 60, 3 (Resolution EB15&R7); 1969, 173, 10 (Resolution EB43&R9)], the following names are selected as Recommended International Nonproprietary Names& The inclusion of a name in the lists of Recommended International Nonproprietary Names does not imply any recommendation of the use of the substance in medicine or pharmacy& Lists of Proposed (173) and Recommended (135) International Nonproprietary Names can be found in Cumulative List No 9, 1996 Dénominations communes internationales des Substances pharmaceutiques (DCI) Dénominations communes internationales RECOMMANDÉES (DCI Rec): Liste 46 Il est notifié que, conformément aux dispositions du paragraphe 7 de la Procédure à suivre en vue du choix de Dénominations communes internationales recommandées pour les Substances pharmaceutiques [Actes off Org mond Santé, 1955, 60, 3 (résolution EB15&R7); 1969, 173, 10 (résolution EB43&R9)] les dénominations ci-dessous sont choisises par lOrganisation mondiale de la Santé en tant que dénominations communes internationales recommandées& Linclusion dune dénomination dans les listes de DCI recommandées nimplique aucune recommandation en vue de lutilisation de la substance correspondante en médecine ou en pharmacie& On trouvera dautres listes de Dénominations communes internationales proposées (173) et recommandées (135) dans la Liste récapitulative No 9, 1996 Denominaciones Comunes Internacionales para las Sustancias Farmacéuticas (DCI) Denominaciones Comunes Internacionales RECOMENDADAS (DCI Rec): Lista 46 De conformidad con lo que dispone el párrafo 7 del Procedimiento de Selección de Denominaciones Comunes Internacionales Recomendadas para las Sustancias Farmacéuticas [Act Of Mund Salud, 1955, 60, 3 (Resolución EB15&R7); 1969, 173, 10 (Resolución EB43&R9)], se comunica por el presente anuncio que las denominaciones que a continuación se expresan han sido seleccionadas como Denominaciones Comunes Internacionales Recomendadas& La inclusión de una denominación en las listas de las Denominaciones Comunes Recomendadas no supone recomendación alguna en favor del empleo de la sustancia respectiva en medicina o en farmacia& Las listas de Denominaciones Comunes Internacionales Propuestas (173) y Recomendadas (135) se encuentran reunidas en Cumulative List No 9, 1996 187 Recommended INN: List 46 WHO Drug Information, Vol 15, No 3-4, 2001 Latin, English, French, Spanish: Recommended INN Chemical name or description; Molecular formula; Graphic formula DCI Recommandée Nom chimique ou description; Formule brute; Formule développée DCI Recomendada Nombre químico o descripción; Fórmula empírica; Fórmula desarrollada abrineurinum abrineurin N-L-methionylneurotrophic factor (human brain-derived) cyclic (13→80),(58→109),(68→111)-tris(disulfide), dimer abrineurine dimère du (13→80),(58→109),(68→111)-tris(disulfure) cyclique du L-méthionylfacteur neurotrophique cerébral humain abrineurina dímero del (13→80),(58→109),(68→111)-tris(disulfuro)cíclico del factor N-L-metionilneurotrófico (derivado de cerebro humano) C H N O S (monomer) 587 947 177 177 10 M HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR acidum carglumicum carglumic acid N-carbamoyl-L-glutamic acid acide carglumique acide (2S)-2-(carbamoylamino)pentanedioïque ácido carglúmico ácido N-carbamoil-L-glutámico C H N O 6 10 2 5 NH2 O H NH HO2C CO2H 188 WHO Drug Information, Vol 15, No 3-4, 2001 Recommended INN: List 46 acidum lidadronicum lidadronic acid [1-amino-3-(dimethylamino)propylidene]diphosphonic acid acide lidadronique acide [1-amino-3-(diméthylamino)propylidène]bisphosphonique ácido lidadrónico ácido[1-amino-3-(dimetilamino)propiliden]difosfónico C H N O P 5 16 2 6 2 OH O P OH H2N OH H3C N P OH CH3 O agalsidasum alfa agalsidase alfa human alpha-galactosidase isoenzyme A, isolated from human cell line, clone RAG 001, glycoform α agalsidase alfa isoenzyme A de lalpha-galactosidase humaine (dimère), glycoforme α produit par la lignée humaine RAG 001 agalsidasa alfa isoenzima A de la alfa-galactosidasa humana glicosilada, aislada de cultivos de células humanas RAG 001, glicoforma α C H N O S 2029 3080 544 587 27 (subunit protein moiety reduced) LDNGLARTPT MGWLHWERFM CNLDCQEEPD SCISEKLFME MAELMVSEGW KDAGYEYLCI DDCWMAPQRD SEGRLQADPQ RFPHGIRQLA NYVHSKGLKL GIYADVGNKT* CAGFPGSFGY YDIDAQTFAD WGVDLLKFDG CYCDSLENLA DGYKHMSLAL NRTGRSIVYS** CEWPLYMWPF QKPNYTEIRQ YCNHWRNFAD IDDSWKSIKS ILDWTSFNQE RIVDVAGPGG WNDPDMLVIG NFGLSWNQQV TQMALWAIMA APLFMSNDLR HISPQAKALL QDKDVIAINQ DPLGKQGYQL RQGDNFEVWE RPLSGLAWAV AMINRQEIGG PRSYTIAVAS LGKGVACNPA CFITQLLPVK RKLGFYEWTS RLRSHINPTG TVLLQLENTM QMSLKDLL * glycosylation sites (asparagine) * sites de glycosylation (asparagine) * posiciones de glicosilación (asparagine) 189 Recommended INN: List 46 WHO Drug Information, Vol 15, No 3-4, 2001 agalsidasum beta agalsidase beta α-galactosidase (human clone λAG18 isoenzyme A subunit protein moiety reduced), glycoform β agalsidase bêta isoenzyme A de lalpha-galactosidase humaine (dimère dont la partie protéique est codée par lADN de cellules λAG18 humaines) glycoforme β produit par culture de cellules ovariennes de hamster chinois (CHO) agalsidasa beta isoenzima A de la α-galactosidasa, fracción proteíca reducida obtenida del clon humano λAG18, glicoforma β C H N O S 2029 3080 544 587 27 (subunit protein moiety reduced) LDNGLARTPT MGWLHWERFM CNLDCQEEPD SCISEKLFME MAELMVSEGW KDAGYEYLCI DDCWMAPQRD SEGRLQADPQ RFPHGIRQLA NYVHSKGLKL GIYADVGNKT CAGFPGSFGY YDIDAQTFAD WGVDLLKFDG CYCDSLENLA DGYKHMSLAL NRTGRSIVYS CEWPLYMWPF QKPNYTEIRQ YCNHWRNFAD IDDSWKSIKS ILDWTSFNQE RIVDVAGPGG WNDPDMLVIG NFGLSWNQQV TQMALWAIMA APLFMSNDLR HISPQAKALL QDKDVIAINQ DPLGKQGYQL RQGDNFEVWE RPLSGLAWAV AMINRQEIGG PRSYTIAVAS LGKGVACNPA CFITQLLPVK RKLGFYEWTS RLRSHINPTG TVLLQLENTM QMSLKDLL alefaceptum alefacept 1-92-antigen LFA-3 (human) fusion protein with human immunoglobulin G1 (hinge-C 2-C 3 γ1-chain), dimer H H aléfacept dimère de la protéine de fusion entre le 1-92-LFA-3 humain et la région charnière C 2-C 3 de la chaîne γ1 de limmunoglobuline G1 humaine H H alefacept dímero de la proteína de fusión entre el 1-92-antígeno LFA-3 humano y la immunoglobulina G1 (cadena γ1 bisagra-C 2-C 3) H H C H N O S 3264 5002 840 988 20 FSQQIYGVVY GNVTFHVPSN VPLKEVLWKK QKDKVAELEN SEFRAFSSFK NRVYLDTVSG SLTIYNLTSS DEDEYEMESP NITDTMKFFL YVDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK 2 190 WHO Drug Information, Vol 15, No 3-4, 2001 Recommended INN: List 46 alfatradiolum alfatradiol estra-1,3,5(10)-triene-3,17α-diol alfatradiol estra-1,3,5(10)-triène-3,17α-diol alfatradiol estra-1,3,5(10)-trieno-3,17α-diol C H O 18 24 2 OH CH3 H H HH HO aprepitantum aprepitant 3-[[(2R,3S)-3-(p-fluorophenyl)-2-[[(αR)-α-methyl- 3,5-bis(trifluoromethyl)benzyl]oxy]morpholino]methyl]-∆3-1,2,4-triazolin-5-one aprépitant 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluorométhyl)phényl]éthoxy]-3- (4-fluorophényl)morpholin-4-yl]méthyl]-1,2-dihydro-3H-1,2,4-triazol-3-one aprepitant 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluorometil)fenil]etoxi]- 3-(4-fluorofenil)morfolin-4-il]metil]-1,2-dihidro-3H-1,2,4-triazol-3-ona C H F N O 23 21 7 4 3 O N O H CH3 HN H N CF3 N O H H CF3 F atrasentanum atrasentan (2R,3R,4S)-1-[(dibutylcarbamoyl)methyl]-2-(p-methoxyphenyl)- 4-[3,4-(methylenedioxy)phenyl]-3-pyrrolidinecarboxylic acid atrasentan acide (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoéthyl]- 2-(4-méthoxyphényl)pyrrolidine-3-carboxylique atrasentán ácido (2R,3R,4S)-1-[(dibutilcarbamoil)metil]-2-(p-metoxifenil)- 4-[3,4-(metilenodioxi)fenil]-3-pirrolidinacarboxílico 191 Recommended INN: List 46 WHO Drug Information, Vol 15, No 3-4, 2001 C H N O 29 38 2 6 O CO2H H H O H N CH3 H3CO N CH3 O aviscuminum aviscumine toxin ML-I (mistletoe lectin I) (Viscum album) aviscumine toxine ML-I (lectine I de gui) (Viscum album) obtenue par génie génétique, constituée par deux chaînes peptidiques A (250 amino-acides) et B (264 amino-acides) liées entre elles par un pont disulfure aviscumina toxina ML-I (lectina I de muérdago) (Viscum album) obtenida por ingeniaria genética, constituida por dos cadenas peptídicas A (250 aminoácidos) y B (264 aminoácidos) unidas entre sí por un puente disulfuro C H N O S ( A ) 1251 1956 346 374 5 C H N O S ( B ) 1255 1983 363 394 15 MYERIRLRVT HQTTGEEYFR FITLLRDYVS SGSFSNEIPL LRQSTIPVSD AQRFVLVELT NQGGDSITAA IDVTNLYVVA YQAGDQSYFL RDAPRGAETH LFTGTTRSSL PFNGSYPDLE RYAGHRDQIP LGIDQLIQSV TALRFPGGST RTQARSILIL IQMISEAARF NPILWRARQY INSGASFLPD VYMLELETSW GQQSTQVQHS TDGVFNNPIR LAIPPGNFVT LTNVRDVIAS LAIMLFVCGE MDDVTCSASE PTVRIVGRNG MCVDVRDDDF RDGNQIQLWP SKSNNDPNQL WTIKRDGTIR SNGSCLTTYG YTAGVYVMIF DCNTAVREAT LWQIWGNGTI INPRSNLVLA ASSGIKGTTL TVQTLDYTLG QGWLAGNDTA PREVTIYGFR DLCMESNGGS VWVETCVSSQ KNQRWALYGD GSIRPKQNQD QCLTCGRDSV STVINIVSCS AGSSGQRWVF TNEGAILNLK NGLAMDVAQA NPKLRRIIIY PATGKPNQMW LPVP 192 WHO Drug Information, Vol 15, No 3-4, 2001 Recommended INN: List 46 balaglitazonum balaglitazone (±)-5-[p-[(3,4-dihydro-3-methyl-4-oxo-2-quinazolinyl)methoxy]benzyl]-
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