Bavarian Biotech Repor
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We have 80,000 R&D centres like this one. Roche develops and produces highly effective treatments and diagnostic tools for diseases such as cancer, hepatitis, diabetes and rheumatoid arthritis. Our innovations help millions of people by alleviating their suffering and improving their quality of life. We give them hope. We Innovate Healthcare WhereWhere the the future future becomes becomes reality reality HHOTSPOTSH FOR LIFE SCIENCE STARTUPS s Lab and offi ce space (S1 & S2) s Competitive leasing rents s Furnished, fl e xible rooms s In-house estate management s The center of an impressive research campus (2 excellent universities TU & LMU, Max Planck Institutes for Bioche- mistry and Neurobiology, Clinic Großhadern, Gene Center, Biomedical Center, Prion Center) s Close contacts with investment partners Am Klopferspitz 19 82152 Planegg/Martinsried s Home for more than 60 startups Tel.: +49 (0) 89 - 700 656 70 s Joint location marketing Fax: +49 (0) 89 - 700 656 77 s Attractive, modern conference rooms also for external booking www.izb-online.de Our tenants in Martinsried: 4SC AG (DD) · AMSilk GmbH (P) · amYmed GmbH (DS) · Bayerische Gewebebank GmbH (P/S) · Bernina Plus & Hartmann Diagnostic Service (DD/DS) · BioM AG (S) · BioM Cluster Development GmbH (S) · Biontex Laboratories GmbH (P) · Blackfield AG (S) · ChromoTek GmbH (DS) · conoGenetix biosciences GmbH (S) · Coriolis Pharma (S) · CRELUX GmbH (DD/DS) · DoNatur GmbH (DD) · DPC Pharma Consulting (S) · EKFS Herzchirurgie Prof. Dr. Eissner (DD) · Ella Biotech GmbH (DS) · eticur) GmbH (DS) · EuMMCR (European Mouse Mutant Cell Repository) (S) · evotec Munich (DD) · Exosome Diagnostics GmbH (DS) · Fresenius Biotech GmbH (DD) · FROST LIFESCIENCE (DS/S) · GNA Biosolution GmbH (I/P) · Helmholtz Zentrum München (S) · IBB Netzwerk GmbH (S) · ibidi GmbH (DS) · Leukocare AG (P/S) · Max-Delbrück Centrum (T-Abs.) (DD/DS) · MenloSystems GmbH (I) · NanoScape AG (P) · Omegametrix GmbH (DS) · origenis GmbH (DD/DS) · Patentquadrat Patentanwaltskanzlei (S) · PELOBiotech (S/P) · PhaToCon (S) · quattro research GmbH (DD/DS) · R&D Biopharmaceuticals GmbH (DD/DS) · SiNatur GmbH (DD) · SIRION Biotech GmbH (P/S) · Smart Move GmbH (I) · Smartec Ingenieur Büro GmbH (S) · SpheroTec GmbH (DS) · SuppreMol GmbH (DD) · that‘s it GmbH (IT-S) · THE WORKING GROUP Unternehmensberatung (S) · TRION Research GmbH (DD/DS) · VELUMETRIX GmbH (S) · Vesalius Biocapital (VC) Our tenants in Freising: AromaLAB AG (S) · ATRES engineering biogas (S) · GENidee (DS) · gimbio mbH (P/S) · HDBI Hans-Dieter-Belitz-Institut (P/I) · Pieris AG (DD) · UGT Umwelt-Geräte-Technik GmbH (P) · vertis Biotechnologie AG (DD/DS) · XL Protein GmbH (DD/P) Furthermore in Martinsried: CEM Chemieschule Dr. Elhardt GmbH · Café Freshmaker · Kindertagesstätte BioKids status: february 13 DD = Drug Discovery · DS = Diagnostic Services · I = Instruments · IT-S = IT-Services · S = Services · VC = Venture Capital · P = Products status: status: february february 13 13 Imprint Editorial staff: Georg Kääb, Bianca Reuter, Daniela Tonn Data collection: Daniel Neumeier, Sabine Jordan Company Profiles: Daniel Neumeier, Monika Bertuleit We thank the Bavarian companies and the regional organizations of the Bavarian Biotechnology Cluster for their support of this survey. April, 2013 Contact Prof. Dr. Horst Domdey, Managing Director Spokesman of the Bavarian Biotechnology Cluster Dr. Georg Kääb, Cluster Manager The Bavarian and the Munich Biotechnology Cluster are managed by: BioM Biotech Cluster Development GmbH Am Klopferspitz 19a D-82152 Martinsried Phone: +49 (0)89-899679-0 Fax: +49 (0)89-899679-79 E-Mail: [email protected] Internet: www.biotech-bavaria.de The layout, graphics and other contents of this brochure of the Bavarian Biotechnology Cluster are protected by copyright law. Layout-Design: aimcom, Munich, www.aimcom.de Picture credits: fotolia.com (© Bastos, © christian-colista, © sergey02); istockphoto.com Supported by the Bavarian State Ministry of Economic Affairs, Infrastructure, Transport and Technology www.stmwivt.bayern.de/en/foreign-trade 4 Content Internationale Anerkennung für Innovationen – Internationally Renowned for Innovation 07 Prof. Dr. Horst Domdey – Spokesman Bavarian Biotechnology Cluster Schnellüberblick – Executive Summary 08–11 Biotechnology: Regional Profiles in Bavaria 12–13 Interview with Claus Haberda, Roche Penzberg 14–15 The network IBB – Biotechnology is an industry application in Bavaria 16 Biotechnology: Science in Bavaria 18–20 Facts and Figures 2012 22–36 Employment 24–25 Jobs in Biotechnology Companies Products and Pipeline 26–28 Drug Development Deals, Cooperation, Mergers, Financing 29–36 Deals and Cooperation Interview with Richard Paulson, Amgen GmbH 30–31 M&A-Activity Milestone Payments Financing Company Profiles 39–148 in alphabetical order About this survey: For the following report, a biotechnology company has been defined as a company, which develops and/or manufactures products on the basis of state-of-the-art molecular biological methods. But as “conventional” pharmaceutical companies are increasingly also using such methods, it is often difficult to differentiate between biotech and pharma. Traditional phytopharmaceutical companies and manufacturers of homeopa- thic products are however not included in this compilation. We distinguished the parameters specific to each sector and conducted separate surveys for biotech companies, pharmaceutical companies, (pre)clini- cal contract research organizations (CROs), contract manufacturing organizations (CMOs), suppliers and others with activities in the biotechnology sector. In the case of the biotech companies, a distinction was once again made between small and medium-sized companies (SMEs) having their headquarters in Bavaria, and branch offices and subsidiaries of national and international biotech companies (biotechnolo- gy companies, non-SMEs). The term “non-SME” therefore does not say anything about the actual size of this branch office. The data forming the basis of this report are based on the evaluation of a written survey carried out by BioM Biotech Cluster Development GmbH at the beginning of 2013 of approx. 340 Life Science companies throughout Bavaria. Based on the questionnaires returned and intensive follow-up telephone calls it was possible to achieve a response rate of almost 90 %. Possible deviations from previously published figures are the result of additional data obtained in this survey that also may refer to previous years. The period under review for this report is the year 2012. Company profiles: There are about 300 companies listed in the appendix of this brochure (page 39 ff). Not every company being listed is also “counted” in this survey (for example those from the Medtech area), and there are other Bavarian biotech and pharma companies having not activated their listing. Published in April 2013 5 Nanotechnology-based Drugs Patented Drugs and branded Generics Innovative Formulations „Creating new values for established drugs!“ Concept Development Drug Approval Patents GMP-Manufacturing leon-nanodrugs is developing nanotechnology-based oral administration. This vital problem in pharmacotherapy reformulations (Generic plus) of successfully marketed can be solved by using our innovative MJR-Technology: brands and generics as well as innovative drug delivery by downsizing particle size to nanoscale, compounds systems for NCEs. Based on our patented superior MJR- become more soluble and faster dissolving in water. The Technology we can process all kinds of application forms unique MJR-Technology allows small and large scale GMP- and a variety of different substance classes like small production any size without changing the hardware. molecules, peptides, hormones and proteins. Each of our API-specific and customized „Generic plus“- More than half of all marketed therapeutic drugs projects is covered by an API-specific formulation patent. are poorly soluble in water or display a low grade of Our technology is superior to all other competitors in terms membrane permeability, limiting their bioavailability and of cost and efficiency. leon-nanodrugs GmbH Kopernikusstr.6 9 D-81679 München T +49.89.41 42 48 89-0 F +49.89.41 42 48 89-88 www.leon-nanodrugs.com Internationale Internationally Anerkennung Renowned für Innovationen for Innovation Die Biotechnologiebranche in Bayern hat ihre Wurzeln in The biotechnology sector in Bavaria has its roots in the den hervorragenden wissenschaftlichen Einrichtungen excellent scientific institutions in the region. On the one des Landes. Hierzu zählen einerseits die heute mit einem hand these are the nationally approved "Excellence" nationalen „Exzellenz-Status“ versehenen universities in Munich (Ludwig-Maximi- Universitäten in München (Ludwig- lian University, LMU,Technical University Maximilians-Universität, LMU; Technische of Munich, TUM) with their hospitals and Universität München, TUM) mit ihren the bioscientific orientated university Kliniken, sowie die biowissenschaftlich institutes in Regensburg, Würzburg, ausgerichteten universitären Institute in Nuremberg-Erlangen and Bayreuth. On Regensburg, Würzburg, Nürnberg-Erlan- the other hand the research institutes of gen und Bayreuth. Andererseits tragen die the Max Planck Society (Max-Planck- Forschungsinstitute der Max-Planck- Institute of Biochemistry and of Neurobi- Gesellschaft (Max-Planck-Institut für ology, both in Martinsried/Munich), the Biochemie sowie für Neurobiologie, beide Helmholtz Centre Munich for Environ- in Martinsried b. München), das Helmholtz