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Descriptive Aspects of Odontoma: Literature Review Aspectos Descriptivos Del Odontoma: Revisión De La Literatura

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Descriptive Aspects of Odontoma: Literature Review Aspectos Descriptivos Del Odontoma: Revisión De La Literatura www.medigraphic.org.mx Revista Odontológica Mexicana Facultad de Odontología Vol. 20, No. 4 October-December 2016 pp 265-269 LITERATURE REVIEW Descriptive aspects of odontoma: literature review Aspectos descriptivos del odontoma: revisión de la literatura Lucía Thistle Barba,* Daniela Muela Campos,§ Martina M Nevárez Rascón,§ Víctor A Ríos Barrera,§ Alfredo Nevárez Rascón§ ABSTRACT RESUMEN Odontoma is the most commonly found odontogenic tumor (35- Los odontomas corresponden a los tumores odontogénicos más 76%). Odontoma is a benign tumor originating from an alteration comunes (35-76%). Es un tumor benigno originado a partir de una of differentiated mesenchymal and epithelial odontogenic cells; alteración de células odontogénicas epiteliales y mesenquimatosas it has the capacity of forming enamel, dentin and cement. They diferenciadas con capacidad de formar esmalte, dentina y cemento. are classifi ed into compound and complex, in a 2:1 relationship, Se clasifi can en compuestos y complejos en una relación de 2:1, the difference between both being dental tissue organization. siendo la diferencia entre ambos la organización del tejido denta- Etiology is still unknown but relation to infections, hereditary rio. La etiología es desconocida pero se ha explorado la ocasión a anomalies, odontoblastic hyperactivity and trauma has been infecciones, anomalías hereditarias, hiperactividad odontoblástica explored. Since these tumors are asymptomatic, 75% of all cases y traumatismos. El 75% de los casos se diagnostican antes de la are diagnosed before the second decade of life, due to a delay in segunda década de vida debido a un retraso en la erupción dental eruption of permanent teeth. Treatment of choice for these tumors permanente, ya que son asintomáticos. El tratamiento es la enu- is enucleation, attempting to preserve the tooth; relapse is very cleación tratando de conservar el diente permanente, siendo las uncommon. recidivas poco frecuentes. Key words: Odontoma, complex odontoma, compound odontoma, odontogenic tumor, impacted retained tooth. Palabras clave: Odontoma, odontoma complejo, odontoma compuesto, tumor odontogénico, diente retenido. INTRODUCTION Etiology Presently, the World Health Organization Etiology of theses tumors is unknown, nevertheless, (WHO) classifies odontoma within the category of some authors have described the possible relationship odontogenic tumors (OT) composed by epithelium with trauma in primary dentition, Malassez paradental and odontogenic ectomesenchyme with or without remains, inflammation processes, odontoblastic formation of mineralized dental tissues.1 The term hyperactivity and hereditary anomalies (Gardner and 8-12 odontoma was coined by Pierre Paul Broca in Herman syndrome). 1867, with it he described any tumor created by Epidemiological aspects the excessive transitory or full growth of dental tissues.2 Later on, in 1946 Thoma KM and Goldman Worldwide reported frequency of odontogenic HM formulated a presently disused odontoma tumors varies to a wide range (1-32%).13 Most of these classifi cation.3 Odontoma are classifi ed taking into account organization and degree of alteration of odontogenic cells, there arewww.medigraphic.org.mx two classifications: * Student of Pediatric Stomatology Master’s Degree, School of compound (CpO) and complex (CO).1,4 Compound Dentistry, Chihuahua Autonomous University, Mexico. odontogenic tumor (CpO) exhibits morphological § Research Professor at the School of Dentistry, Autonomous Uni- versity of Chihuahua, Mexico. and histological differentiation, while complex odontogenic tumor (CO) only presents histological Received: January 2015. Accepted: March 2016. differentiation.5 In CpO multiple amorphous dental © 2016 Universidad Nacional Autónoma de México, [Facultad de structures are formed (denticles), while in CO a Odontología]. This is an open access article under the CC BY-NC- solid mass of dental soft and hard tissues is formed, ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). these tissues are haphazardly arranged and do not This article can be read in its full version in the following page: resemble the morphology of a tooth.4,6,7 http://www.medigraphic.com/facultadodontologiaunam Thistle BL et al. Descriptive aspects of odontoma 266 series report odontoma as the most prevalent lesion the oral cavity.7 Crespo et al, reported a case of chronic of odontogenic tumors in an interval of 35 to 76%.13- maxillary sinusitis secondary to drain obstruction caused 19 Buchner et al,13 studied in 2006 a sample of 1,088 by an odontoma;37 Suenaga et al presented the case odontogenic tumors, of which 76% corresponded to of a complex odontoma located in the right nasal fossa odontoma. Previous to that, in 1997, Mosqueda Taylor which caused nasal obstruction and bleeding.18 et al examined 349 odontogenic tumors, out of which Amado-Cuesta et al conducted a literature review in 35% were odontoma.14 This difference in prevalence which they reviewed 38 cases of compound odontoma. among various studies can be due to differences in In that review denticle numbers varied from 4 to 28. terminology and classifi cation; possible association to In a case reported by Sharma et al a compound ethnic or genetic aspects is equally suggested.8 odontoma with 37 denticles was extracted; denticles Odontoma frequency according to gender has been exhibited concrescence, fusion and laceration.11 variously reported in several studies, to this date no consensus has been reached, this can be due to the Radiographic characteristics subtle prevalence differences reported between both genders.8 Compound odontoma (Figure 1) can be observed Some authors report higher prevalence in as radio-opaque masses with irregular margins females17,20-22 while others have reported higher adopting a tooth-like confi guration; they present radio- prevalence in males.13,23-25 Hidalgo O et al conducted lucid peripheral borders, whilst complex odontoma in 2008 a meta-analysis on epidemiological exhibit unique radio-opacity.4 According to the degree characteristics of odontoma. They studied 3,065 cases of odontoma calcifi cation, three stages of development and mention in their results that 49.4% were female can be identifi ed: in the fi rst stage the lesion appears patients and 50.6% males.8 Concluding thus there radio-lucid (due to lack of calcification of dental was no significant difference according to gender; tissues), the intermediate stage is characterized by this concurs with different studies.14,26-28 According to partial calcifi cation, and in the fi nal stage the odontoma age diagnosis, odontoma can be identified at wide appears radio-opaque and surrounded by a radio-lucid age ranges, nevertheless a high prevalence peak is halo (Figure 2).21 reported in the second decade of life.21,25,27-30 Histological characteristics Clinical characteristics From a histological point of view, compound In scientifi c literature, three clinical presentations odontoma (Figure 3) are characterized by presence of of odontoma have been recognized: intra-osseous, dental tissue, demineralized enamel, dentin, cement extra-osseous and erupted. Intra-osseous odontoma and pulp, arranged in an organized manner of dental are the most frequent.31 The most frequently reported structures and partially surrounded by a connective location is the incisor-canine area of the upper jaw tissue capsule. Conversely, complex odontoma (Figure (67%) followed by lower-anterior and lower-posterior 4) exhibit a disorganized mass of hard dental tissue;6 areas of the lower jaw (33%).14,26-28,32 CpO clearly odontogenic epithelium strands can be found in the appear more frequently than complex odontoma in periphery,20 and sometimes, presence of phantom the anterior section of the upper jaw over the crown cells, cementicles and ameloblastic epithelium can of one of more non-erupted teeth, or between roots be detected.4 These tumors can be associated to of erupted teeth (61%) (Figure 1), whereas complex other odontogenic tumors such as ameloblastoma, odontoma most frequently appears in the posterior ameloblastic fi bro-odontoma, odonto-ameloblastoma, section of the mandible (59%) (Figure 2).8,33,34 calcifying epithelial odontogenic tumor, adenomatoid Some other more uncommonwww.medigraphic.org.mx isolated cases have odontogenic tumor and dentigerous cyst, therefore been reported in the maxillary sinus, nasal cavity and histopathological study is recommended in all cases.15 fl oor of the orbit.8 Soluk Tekkesin M et al, conducted a study in 2012 Odontoma are benign, not very aggressive tumors where they assessed histological characteristics of which usually do not elicit symptoms; over half the 160 odontoma. Within their results they mention that cases are discovered as radiographic fi ndings (57%).8 ameloblastic epithelium was more frequently observed Different studies report an association (16-61%) with in complex odontoma, whereas mesenchimal impacted teeth.35,36 odontogenic tissue was mainly observed in compound Most odontoma are intra-osseous, nevertheless there odontoma; they equally reported that phantom cells are reported cases of odontoma which have erupted into were found in up to 20% of examined samples.4 Revista Odontológica Mexicana 2016;20 (4): 265-269 267 A B Figure 1. A) Compound odontoma in lower premolars. B) Macroscopic image of compound odontoma constituted by a capsule of fibrous tissue and multiple denticles. A B Figure 2. A) Periapical projection of complex odontoma. B) Complex odontoma in the area of lower premolars (orthopantomography).
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