Iii Bds Oral Pathology and Microbiology
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Applications of Cytokeratin Expression in the Diagnosis of Oral Diseases
Jemds.com Review Article Applications of Cytokeratin Expression in the Diagnosis of Oral Diseases Archana Sonone1, Alka Hande2, Madhuri Gawande3,Swati Patil4 1, 2, 3, 4 Department of Oral Pathology and Microbiology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed to Be University) Sawangi (Meghe), Wardha, Maharashtra, India. ABSTRACT All mammalian cells have a complex intracytoplasmic cytoskeleton made up of three Corresponding Author: main structural units and related proteins, tubulin containing microtubules, actin Dr. Archana Sonone. Department of Oral Pathology and containing microfilaments, and Intermediate Filaments (IF). There are six types of Microbiology, Sharad Pawar Dental IFs; cytokeratin fibres consisting of type I and type II IFs. Cytokeratins (CK), College, Datta Meghe Institute of Medical . comprising of collections of IFs that are explicitly communicated by epithelial tissues Sciences (Deemed to Be University) There are 20 unique polypeptides of CK expressed by epithelium that have been Sawangi (Meghe), Wardha, Maharashtra, indexed based on their molecular weight (range 40-70 kDa). India. CK and associated filaments give a framework to epithelial cells and tissues to E-mail: [email protected] maintain their structural integrity. Thus, ensure mechanical resilience, sustain stress, establish cell polarity, and to protect against variations in hydrostatic pressure. DOI: 10.14260/jemds/2021/50 Genetic encoding of cytokeratins shows homogeneous “nucleotide sequence”. 54 How to Cite This Article: genes are responsible for encoding of cytokeratin in humans which are congregated Sonone A, Hande A, Gawande M, et al. on chromosome no. 2. Genetic mutation of cytokeratins is important for Applications of cytokeratin expression in pathophysiology of various mucocutaneous disorders, which is mostly autosomal the diagnosis of oral diseases. -
Oralmedicine
116 Test 98.2 ORAL MEDICINE Developmental Mandibular Salivary Gland Defect The Importance of Clinical Evaluation developmental mandibular salivary gland defect (also known as static A bone cyst, static bone defect, Stafne bone cavity, latent bone cyst, latent bone defect, idiopathic bone cavity, developmen- tal submandibular gland defect of the mandible, aberrant salivary gland defect in the mandible, and lingual mandibular bone Sako Ohanesian, concavity) is a deep, well-defined depression DDS in the lingual surface of the posterior body of the mandible. More precisely, the most common location is within the submandibu- lar gland fossa and often close to the inferi- or border of the mandible. In developmental bone defects investigated surgically, an aberrant lobe of the submandibular gland extends into the bony depression. First recognized by Dr. Edward Stafne in 1942, numerous cases of developmental mandibular salivary gland defect have since been reported, and the lesion should not be considered rare.1 In a study of 4963 pan- Most authorities now agree that this entity is a congenital defect, although it has rarely been observed in children and its precise anatomic nature is still uncertain. oramic images of adult patients, 18 cases of Figure 1. CT slices/panoramic views showing a well-defined radiolucent lesion in the right mandible. salivary gland depression were found by Karmiol and Walsh2, an incidence of nearly 0.4%. Most authorities now agree that this The margins of the radiolucent defect are around an extension of salivary tissue. This entity is a congenital defect, although it has well-defined by a dense radiopaque line. -
Peripheral Giant Cell Reparative Granuloma of Maxilla in a Patient with Aggressive Periodontitis
Peripheral Giant Cell Reparative Granuloma of Maxilla in a Patient with Aggressive Periodontitis E Cayci1, B Kan2, E Guzeldemir-Akcakanat1, B Muezzinoglu3 1Department of Periodontology, Kocaeli University, Faculty of Dentistry, Kocaeli, Turkey. 2Department of Oral and Maxillofacial Surgery, Kocaeli University, Faculty of Dentistry, Kocaeli, Turkey. 3Department of Pathology, Kocaeli University, School of Medicine, Kocaeli, Turkey. Abstract Peripheral giant cell reparative granuloma is a reactive and rare lesion of oral cavity with unknown etiology which is derived from periosteum and periodontal ligament and occurs frequently in young adults. Inflammation or trauma is underlying causative factor of reactive proliferation. In the present case report, a 35 year-old male with aggressive periodontitis and peripheral giant cell reparative granuloma is presented. The patient applied to our clinic with a complaining about a big nodule at his palate. The lesion was pedunculated and localized at his right maxilla between #16 and #17 which arose from distal aspect of #16, and the surface of the lesion was hyperkeratotic and the lesion was measured 22 x 30 mm at the largest diameter. He also had severe generalized aggressive periodontitis and hypertension. Amoxicillin clavulanate 625 mg, three times a day, metronidazole 500 mg three times a day and 0.2% chlorhexidine digluconate oral rinse, twice a day for a week, were prescribed to the patient. Then, scaling and root planing were performed along with systemic antibiotic treatment and he scheduled for surgery. The lesion was excised completely and #16 was extracted. After the healing period, periodontal surgery was planned for the treatment of aggressive periodontitis. Obtained tissue specimen was sent for histopathological examination. -
Oral Path Questions
Oral Pathology Oral Pathology • Developmental Conditions • Mucosal Lesions—Reactive • Mucosal Lesions—Infections • Mucosal Lesions—Immunologic Diseases • Mucosal Lesions—Premalignant • Mucosal Lesions—Malignant • CT Tumors—Benign • CT Tumors—Malignant • Salivary Gland Diseases—Reactive • Salivary Gland Diseases—Benign • Salivary Gland Diseases—Malignant • Lymphoid Neoplasms • Odontogenic Cysts • Odontogenic Tumors • Bone Lesions—Fibro-Osseous • Bone Lesions—Giant Cell • Bone Lesions—Inflammatory • Bone Lesions—Malignant • Hereditary Conditions #1 One of the primary etiologic agents of aphthous stomatitis is proposed to be: A. Cytomegalovirus B. Staphylococcus C. Herpes simplex D. Human leukocyte antigen E. Candidiasis #1 One of the primary etiologic agents of aphthous stomatitis is proposed to be: A. Cytomegalovirus B. Staphylococcus C. Herpes simplex D. Human leukocyte antigen E. Candidiasis #2 Intracellular viral inclusions are seen in tissue specimens of which of the following? A. Solar cheilitis B. Minor aphthous ulcers C. Geographic tongue D. Hairy leukoplaKia E. White sponge nevus #2 Intracellular viral inclusions are seen in tissue specimens of which of the following? A. Solar cheilitis B. Minor aphthous ulcers C. Geographic tongue D. Hairy leukoplakia E. White sponge nevus #3 Sjogren’s Syndrome has been linKed to which of the following malignancies? A. Leukemia B. Lymphoma C. Pleomorphic adenoma D. Osteosarcoma #3 Sjogren’s Syndrome has been linKed to which of the following malignancies? A. Leukemia B. Lymphoma C. Pleomorphic adenoma D. Osteosarcoma #4 Acantholysis, resulting from desmosome weaKening by autoantibodies directed against the protein desmoglein, is the disease mechanism attributed to which of the following? A. Epidermolysis bullosa B. Mucous membrane pemphigoid C. Pemphigus vulgaris D. Herpes simplex infections E. -
Oral Pathology and Oral Microbiology
3.3.2 SYLLABUS ( Including Teaching Hours.) MUST KNOW 109 HRS 1 Developmental Disturbances of oral and paraoral structures 03 HRS Developmental disturbances of hard tissues: -dental arch relations, -disturbances related to - -size,shape,number and structure of teeth, -disturbances related to eruption and shedding. Developmental disturbances of soft tissues: Lip,palate,oral mucosa,gingival,tongue and salivary glands Craniofacial anomalies 2 Benign and Malignant tumors of oral cavity 25 HRS Potentially Malignant Disorders of epithelial tissue origin. -Definitions and nomenclature -Epithelial dysplasia -Lesions and conditions:leukoplakia, erythroplakia,oral lichen planus and oral submucous fibrosis. Benign tumors of epithelial tissue origin. - Squamous papilloma, Oral nevi. Malignant tumors of epithelial tissue origin. -Oral squamous cell carcinoma: Definition and nomenclature,etiopathogenesis, TNM staging ,Broder’s and Bryne’s grading systems. -Verrucous carcinoma -Basal cell carcinoma: Definition etiopathogenesis and histopathology -Malignant melanoma: Definition etiopathogenesis and histopathology Benign and malignant tumors of connective tissue -Fibroblast origin:oral fibromas and fibromatosis,peripheral ossifying fibroma peripheral giant cell granuloma, pyogenic granuloma and Fibrosarcoma -Adipose tissue origin:Lipoma -Endothelial origin(blood and lymphatics: Hemangiomas and lymphangiomas, Hereditary hemorrhagic telangiactasia, Kaposi’s sarcoma Bone and cartilage: Chondroma,osteoma,osteoid osteoma, benign osteoblastoma, osteosarcoma, -
Oral Pathology Final Exam Review Table Tuanh Le & Enoch Ng, DDS
Oral Pathology Final Exam Review Table TuAnh Le & Enoch Ng, DDS 2014 Bump under tongue: cementoblastoma (50% 1st molar) Ranula (remove lesion and feeding gland) dermoid cyst (neoplasm from 3 germ layers) (surgical removal) cystic teratoma, cyst of blandin nuhn (surgical removal down to muscle, recurrence likely) Multilocular radiolucency: mucoepidermoid carcinoma cherubism ameloblastoma Bump anterior of palate: KOT minor salivary gland tumor odontogenic myxoma nasopalatine duct cyst (surgical removal, rare recurrence) torus palatinus Mixed radiolucencies: 4 P’s (excise for biopsy; curette vigorously!) calcifying odontogenic (Gorlin) cyst o Pyogenic granuloma (vascular; granulation tissue) periapical cemento-osseous dysplasia (nothing) o Peripheral giant cell granuloma (purple-blue lesions) florid cemento-osseous dysplasia (nothing) o Peripheral ossifying fibroma (bone, cartilage/ ossifying material) focal cemento-osseous dysplasia (biopsy then do nothing) o Peripheral fibroma (fibrous ct) Kertocystic Odontogenic Tumor (KOT): unique histology of cyst lining! (see histo notes below); 3 important things: (1) high Multiple bumps on skin: recurrence rate (2) highly aggressive (3) related to Gorlin syndrome Nevoid basal cell carcinoma (Gorlin syndrome) Hyperparathyroidism: excess PTH found via lab test Neurofibromatosis (see notes below) (refer to derm MD, tell family members) mucoepidermoid carcinoma (mixture of mucus-producing and squamous epidermoid cells; most common minor salivary Nevus gland tumor) (get it out!) -
Compound Odontoma in the Anterior Maxilla
Oncology and Radiotherapy © 1 (46) 2019: 043-045 • CASE REPORT Compound odontoma in the anterior maxilla Ramesh Kunusoth1, Vikas Sahu1, Afreen Fathima2, Rathod Prakash1, Sampath Kumar Pala1, Kotya Naik Maloth3 1 Department of Oral and Maxillofacial Surgery, MNR Dental College and Hospital, Telangana, India 2 Department of Oral Medicine and Radiology, MNR Dental College and Hospital, Telangana, India 3 Department of Oral Medicine and Radiology, Mamata Dental College and Hospital, Telangana, India Odontomas are commonly reported in the dental literature, as they arise from odontogenic epithelium referred to as a mixed INTRODUCTION odontogenic tumor. It is considered to be hamartomas rather than the tumor, characterized by an abnormal calcified mass of dental Background SUMMARY tissues like enamel, dentin, pulp, and cementum. World Health Organization (WHO) classified odontoma into two types, compound Odontoma is a developmental anomaly and considered and complex types based on radiological features. The exact etiology is unknown, but based on the literature postulated causes included to be hamartomas rather than the tumor, characterized by an local trauma, infection, and genetic mutations. Clinically represented abnormal calcified mass of dental tissues like enamel, dentin, as asymptomatic swelling and pain secondary to infection. Here, we report a case of compound odontoma in the anterior maxilla in 20 pulp, and cementum. It is the most comment mixed odontogenic years female patient. tumor occurring in the oral cavity, resulting in the progression Key words: compound odontoma, hamartoma, odontogenic tumor of completely differentiated epithelial and mesenchymal cells, which appear normal or defect in structure [1, 2]. Address for correspondence: Odontoma term is used to denote lesions that contain all Ramesh Kunusoth, Department of Oral and Maxillofacial Surgery, MNR Dental College and Hospital, MNR Nagar, Fasalwadi, Sangareddy, the dental tissues such as enamel, dentin, pulp, and cementum Telangana, 502294, India, email: [email protected] [3]. -
Adverse Effects of Medicinal and Non-Medicinal Substances
Benign? Not So Fast: Challenging Oral Diseases presented with DDX June 21st 2018 Dolphine Oda [email protected] Tel (206) 616-4748 COURSE OUTLINE: Five Topics: 1. Oral squamous cell carcinoma (SCC)-Variability in Etiology 2. Oral Ulcers: Spectrum of Diseases 3. Oral Swellings: Single & Multiple 4. Radiolucent Jaw Lesions: From Benign to Metastatic 5. Radiopaque Jaw Lesions: Benign & Other Oral SCC: Tobacco-Associated White lesions 1. Frictional white patches a. Tongue chewing b. Others 2. Contact white patches 3. Smoker’s white patches a. Smokeless tobacco b. Cigarette smoking 4. Idiopathic white patches Red, Speckled lesions 5. Erythroplakia 6. Georgraphic tongue 7. Median rhomboid glossitis Deep Single ulcers 8. Traumatic ulcer -TUGSE 9. Infectious Disease 10. Necrotizing sialometaplasia Oral Squamous Cell Carcinoma: Tobacco-associated If you suspect that a lesion is malignant, refer to an oral surgeon for a biopsy. It is the most common type of oral SCC, which accounts for over 75% of all malignant neoplasms of the oral cavity. Clinically, it is more common in men over 55 years of age, heavy smokers and heavy drinkers, more in males especially black males. However, it has been described in young white males, under the age of fifty non-smokers and non-drinkers. The latter group constitutes less than 5% of the patients and their SCCs tend to be in the posterior mouth (oropharynx and tosillar area) associated with HPV infection especially HPV type 16. The most common sites for the tobacco-associated are the lateral and ventral tongue, followed by the floor of mouth and soft palate area. -
Abstracts of the XXI Brazilian Congress of Oral Medicine and Oral Pathology
Vol. 117 No. 2 February 2014 Abstracts of the XXI Brazilian Congress of Oral Medicine and Oral Pathology ORAL PRESENTATIONS GERMANO, MÁRCIA CRISTINA DA COSTA MIGUEL, ÉRICKA JANINE DANTAS DA SILVEIRA. UNIVERSIDADE AO-01 - MAXILLARY OSTEOSARCOMA INITIALLY FEDERAL DO RIO GRANDE DO NORTE. RESEMBLING PERIAPEX DENTAL INJURY: CLINICAL Renal osteodystrophy represents the musculoskeletal mani- CASE REPORT. JOANA DOURADO MARTINS, JARIELLE festations resulting from metabolic abnormalities in patients with OLIVEIRA MASCARENHAS ANDRADE, JULIANA ARAUJO chronic renal failure (CRF). Woman, 23, reported a hard, asymp- LIMA DA SILVA, ALESSANDRA LAIS PINHO VALENTE, tomatic, expansive mass present for 4 years on the right side of the MÁRCIO CAMPOS OLIVEIRA, MICHELLE MIRANDA face that was causing airway compromise and facial disfigurement. LOPES FALCÃO, VALÉRIA SOUZA FREITAS. UNI- Her history included idiopathic CRF, and she had been receiving VERSIDADE ESTADUAL DE FEIRA DE SANTANA. hemodialysis for 10 years. During this period she developed sec- Maxillary osteosarcoma is a rare and aggressive bone tumor ondary hyperparathyroidism that was managed with total para- that can initially resemble a periapical lesion. Man, 42, came to the thyroidectomy. Computed tomography revealed marked osseous Oral Lesions Reference Center at UEFS complaining of “tooth expansion on the right side of the maxilla and discrete expansion numbness and swollen gums” and loss of sensation in the anterior on the right side of mandible and cranial base. The clinical diag- teeth. His history included previous endodontic emergency treat- nosis was brown tumor. Incisional biopsy led to a diagnosis of ment of units 1.1 and 2.1. The extraoral examination demonstrated renal osteodystrophy. -
Odontoameloblastoma: a Report of a Rare Case
Case Report Odontoameloblastoma: A report of a rare case Karpagaselvi Sanjai1, Bhavna Pandey2, Divya Shivalingaiah1, Harish Muniswamy Kumar1 1Vydehi Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, 2Department of Oral Pathology, Chettinad Dental College and Hospital, Kanchipuram, Tamil Nadu, India Abstract Odontoameloblastoma (OA) is an uncommon mixed odontogenic tumor that contains an ameloblastomatous component and odontoma-like elements, usually seen to occur in the mandible of younger patients. Radiographically, the tumor shows central destruction of bone with extension of cortical plates and calcified structures which have the radiopacity of tooth structure. These may resemble miniature teeth similar to a compound odontoma or occur as large masses of calcified material similar to a complex odontoma. We report a case of a 17-year-old male with a hard solitary, diffuse swelling over the right lower third of the face for 8 months. Histopathological sections of tumor mass showed diverse and characteristic features of ameloblastoma along with odontogenic epithelium proliferation in unrestrained manner so as to resemble developing tooth bud in stages of morphodifferentiation, apposition and calcification. A diagnosis of OA was made. Hemimandibulectomy was performed on the patient and he remains disease free till today. Keywords: Ameloblastic odontoma, ameloblastoma, complex odontoma, odontoameloblastoma, odontogenic tumor Address for correspondence: Dr. Karpagaselvi Sanjai, Vydehi Institute of Dental Sciences and Research Centre, 82, EPIP Area, Nallurahalli, Bengaluru ‑ 560 066, Karnataka, India. E‑mail: [email protected] Received: 01.09.2017, Accepted: 18.06.2018 INTRODUCTION in both structure and behavior. Due to the presence of odontogenic ectomesenchyme, inductive changes take The combination of two odontogenic tumors is seldom place leading to the formation of dentin and enamel in seen in the field of odontogenic tumors. -
47 Peripheral Compound Odontoma: a Rare Case Report
International Journal of Medicine Research International Journal of Medicine Research ISSN: 2455-7404; Impact Factor: RJIF 5.42 www.medicinesjournal.com Volume 2; Issue 3; May 2017; Page No. 47-50 Peripheral compound odontoma: A rare case report 1 Mariem Meddeb, 2 Sameh Sioud, 3 Chiraz Baccouche, 4 Mounir Omami, 5 Jemil Selmi 1, 2, 4, 5 Department of Medicine and Oral Surgery of the Dentistry Clinic of Monastir, Tunisia 3 Departmen of Dental Anatomy of The Dentistry Clinic of Monastir, Tunisia Abstract Odontomas are the most common odontogenic tumors. They are considered to be hamartomatous malformation rather than true neoplasm. They develop from epithelial and mesenchymal components of the dental apparatus, producing enamel and dentin. Clinically, they may be classified as intraosseous and peripheral odontomas. Although most of the odontomas are asymptomatic, yet these are often associated with tooth eruption disturbances and malocclusion. Keywords: odontoma, peripheral, compound Introduction Odontomas, one of the most common benign odontogenic tumors of epithelial and mesenchymal origin. They are considered actually as hamartomas or developmental anomalies composed of enamel, dentin, cementum and pulp tissue [1]. Peripheral or soft tissue odontomas, those arising in the soft tissue, are rare, judging from the paucity in the literature, or are rarely reported. This excludes those that were in the bone and subsequently erupted [2]. The aim of this article is to report clinical case of compound peripheral odontoma which be diagnosed and treated at the department of Medicine and Oral Surgery of the Dentistry Clinic of Monastir, Tunisia. Case report A 12 year-old male patient with no notable medical history; referred by the pediatric dentistry department for bone Fig 1 swelling in relation to the maxillary left lateral incisor. -
Description Concept ID Synonyms Definition
Description Concept ID Synonyms Definition Category ABNORMALITIES OF TEETH 426390 Subcategory Cementum Defect 399115 Cementum aplasia 346218 Absence or paucity of cellular cementum (seen in hypophosphatasia) Cementum hypoplasia 180000 Hypocementosis Disturbance in structure of cementum, often seen in Juvenile periodontitis Florid cemento-osseous dysplasia 958771 Familial multiple cementoma; Florid osseous dysplasia Diffuse, multifocal cementosseous dysplasia Hypercementosis (Cementation 901056 Cementation hyperplasia; Cementosis; Cementum An idiopathic, non-neoplastic condition characterized by the excessive hyperplasia) hyperplasia buildup of normal cementum (calcified tissue) on the roots of one or more teeth Hypophosphatasia 976620 Hypophosphatasia mild; Phosphoethanol-aminuria Cementum defect; Autosomal recessive hereditary disease characterized by deficiency of alkaline phosphatase Odontohypophosphatasia 976622 Hypophosphatasia in which dental findings are the predominant manifestations of the disease Pulp sclerosis 179199 Dentin sclerosis Dentinal reaction to aging OR mild irritation Subcategory Dentin Defect 515523 Dentinogenesis imperfecta (Shell Teeth) 856459 Dentin, Hereditary Opalescent; Shell Teeth Dentin Defect; Autosomal dominant genetic disorder of tooth development Dentinogenesis Imperfecta - Shield I 977473 Dentin, Hereditary Opalescent; Shell Teeth Dentin Defect; Autosomal dominant genetic disorder of tooth development Dentinogenesis Imperfecta - Shield II 976722 Dentin, Hereditary Opalescent; Shell Teeth Dentin Defect;