Oral Pathology and Oral Microbiology
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Applications of Cytokeratin Expression in the Diagnosis of Oral Diseases
Jemds.com Review Article Applications of Cytokeratin Expression in the Diagnosis of Oral Diseases Archana Sonone1, Alka Hande2, Madhuri Gawande3,Swati Patil4 1, 2, 3, 4 Department of Oral Pathology and Microbiology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed to Be University) Sawangi (Meghe), Wardha, Maharashtra, India. ABSTRACT All mammalian cells have a complex intracytoplasmic cytoskeleton made up of three Corresponding Author: main structural units and related proteins, tubulin containing microtubules, actin Dr. Archana Sonone. Department of Oral Pathology and containing microfilaments, and Intermediate Filaments (IF). There are six types of Microbiology, Sharad Pawar Dental IFs; cytokeratin fibres consisting of type I and type II IFs. Cytokeratins (CK), College, Datta Meghe Institute of Medical . comprising of collections of IFs that are explicitly communicated by epithelial tissues Sciences (Deemed to Be University) There are 20 unique polypeptides of CK expressed by epithelium that have been Sawangi (Meghe), Wardha, Maharashtra, indexed based on their molecular weight (range 40-70 kDa). India. CK and associated filaments give a framework to epithelial cells and tissues to E-mail: [email protected] maintain their structural integrity. Thus, ensure mechanical resilience, sustain stress, establish cell polarity, and to protect against variations in hydrostatic pressure. DOI: 10.14260/jemds/2021/50 Genetic encoding of cytokeratins shows homogeneous “nucleotide sequence”. 54 How to Cite This Article: genes are responsible for encoding of cytokeratin in humans which are congregated Sonone A, Hande A, Gawande M, et al. on chromosome no. 2. Genetic mutation of cytokeratins is important for Applications of cytokeratin expression in pathophysiology of various mucocutaneous disorders, which is mostly autosomal the diagnosis of oral diseases. -
Benign Cementoblastoma Associated with an Impacted Mandibular Third Molar – Report of an Unusual Case
Case Report Benign Cementoblastoma Associated with an Impacted Mandibular Third Molar – Report of an Unusual Case Chethana Dinakar1, Vikram Shetty2, Urvashi A. Shetty3, Pushparaja Shetty4, Madhvika Patidar5,* 1,3Senior Lecturer, 4Professor & HOD, Department of Oral Pathology and Microbiology, AB Shetty Memorial Institute of Dental Science, Mangaloge, 2Director & HOD, Nittee Meenakshi Institute of Craniofacial Surgery, Mangalore, 5Senior Lecturer, Department of Oral Pathology and Microbiology, Babu Banarasi Das College of Dental Sciences, Lucknow *Corresponding Author: Email: [email protected] ABSTRACT Cementoblastoma is characterized by the formation of cementum-like tissue in direct connection with the root of a tooth. It is a rare lesion constituting less than 1% of all odontogenic tumors. We report a unique case of a large cementoblastoma attached to the lateral root surface of an impacted permanent mandibular third molar in a 33 year old male patient. The association of cementoblastomas with impacted teeth is a rare finding. Key Words: Odontogenic tumor, Cementoblastoma, Impacted teeth, Third molar, Cementum Access this article online opening limited to approximately 10mm. The swelling Quick Response was firm to hard in consistency and tender on palpation. Code: Website: Lymph nodes were not palpable. www.innovativepublication.com On radiographical examination, it showed a large, well circumscribed radiopaque mass attached to the lateral root surface of impacted permanent right mandibular DOI: 10.5958/2395-6194.2015.00005.3 third molar. The mass displayed a radiolucent area at the other end and was seen occupying almost the entire length of the ramus of mandible. The entire lesion was INTRODUCTION surrounded by a thin, uniform radiolucent line (Fig. -
Glossary for Narrative Writing
Periodontal Assessment and Treatment Planning Gingival description Color: o pink o erythematous o cyanotic o racial pigmentation o metallic pigmentation o uniformity Contour: o recession o clefts o enlarged papillae o cratered papillae o blunted papillae o highly rolled o bulbous o knife-edged o scalloped o stippled Consistency: o firm o edematous o hyperplastic o fibrotic Band of gingiva: o amount o quality o location o treatability Bleeding tendency: o sulcus base, lining o gingival margins Suppuration Sinus tract formation Pocket depths Pseudopockets Frena Pain Other pathology Dental Description Defective restorations: o overhangs o open contacts o poor contours Fractured cusps 1 ww.links2success.biz [email protected] 914-303-6464 Caries Deposits: o Type . plaque . calculus . stain . matera alba o Location . supragingival . subgingival o Severity . mild . moderate . severe Wear facets Percussion sensitivity Tooth vitality Attrition, erosion, abrasion Occlusal plane level Occlusion findings Furcations Mobility Fremitus Radiographic findings Film dates Crown:root ratio Amount of bone loss o horizontal; vertical o localized; generalized Root length and shape Overhangs Bulbous crowns Fenestrations Dehiscences Tooth resorption Retained root tips Impacted teeth Root proximities Tilted teeth Radiolucencies/opacities Etiologic factors Local: o plaque o calculus o overhangs 2 ww.links2success.biz [email protected] 914-303-6464 o orthodontic apparatus o open margins o open contacts o improper -
Misdiagnosis of Osteosarcoma As Cementoblastoma from an Atypical Mandibular Swelling: a Case Report
ONCOLOGY LETTERS 11: 3761-3765, 2016 Misdiagnosis of osteosarcoma as cementoblastoma from an atypical mandibular swelling: A case report ZAO FANG1*, SHUFANG JIN1*, CHENPING ZHANG1, LIZHEN WANG2 and YUE HE1 1Department of Oral Maxillofacial Head and Neck Oncology, Faculty of Oral and Maxillofacial Surgery; 2Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, P.R. China Received December 1, 2014; Accepted January 12, 2016 DOI: 10.3892/ol.2016.4433 Abstract. Cementoblastoma is a form of benign odontogenic of the lesion with extraction of the associated tooth (2); tumor, with the preferred treatment consisting of tooth extrac- however, certain patients may decide against surgery, under- tion and follow-up examinations, while in certain cases, going follow-up alone. Osteosarcoma is a non-hematopoietic, follow-up examinations without surgery are performed. malignant tumor of the bone, with the neoplastic cells of the Osteosarcoma of the jaw is a rare, malignant, mesenchymal lesion producing osteoid (3). This form of tumor is character- tumor, associated with a high mortality rate and low incidence ized by high malignancy, metastasis and mortality rates (4). of metastasis. Cementoblastoma and osteosarcoma of the jaw The tumors are most prevalently located in the metaphyseal are dissimilar in terms of their histological type and prognosis; region of long bones, particularly in the knee and pelvis (5). however, there are a number of covert associations between Osteosarcoma of the jaw is rare, accounting for 5-13% of all them. The present study describes the case of a 20-year-old osteosarcoma cases (6), the majority of which are located in female with an unusual swelling in the left mandible that the mandible. -
Benign Cementoblastoma Associated with an Unerupted Third Molar - a Case Report
CORE Metadata, citation and similar papers at core.ac.uk Provided by Directory of Open Access Journals BENIGN CEMENTOBLASTOMA ASSOCIATED WITH AN UNERUPTED THIRD MOLAR - A CASE REPORT J.Dinakar* M.S.Senthil Kumar** Shiju Mathew Jacob*** *Professor & HOD, Department of Oral Pathology, ** Reader, *** Lecturer, Department of Oral Surgery, Sri Ramakrishna Dental College and Hospital, Coimbatore, Tamilnadu, India. ABSTRACT: Cementoblastoma is a rare odontogenic tumor derived from odontogenic ectomesenchyme of cementoblast origin that forms cementum layer on the roots of a tooth. A case report is presented of a patient treated with surgical excision of Cementoblastoma associated with an unerupted infected right lower third molar tooth. Key words: Cementoblastoma, Odontogenic tumour, unerupted third molar. The cell of origin is cementoblast. INTRODUCTION: Clinically it causes bony expansion. The commonest site is the posterior region of Cementoblastoma is an odontogenic the mandible. In the radiograph it is seen tumor of ectomesenchymal origin. It is as large radiopaque mass associated with also called cementoma. They are large the root of the tooth. We report a case of bulbous mass of cementum or cementum- Benign Cementoblastoma from Sri like tissue on roots of teeth. Ramakrishna Dental College & Hospital, Coimbatore. restriction in opening the mouth and intra oral examination reveals a partially CASE REPORT: erupted third molar tooth with pus discharge. A panoramic radiograph A 41 year old man presented to our showed a radio-opaque, dense, department with a complaint of pain and amorphous, irregularly shaped mass swelling in the right lower half of the face. measuring 2.2 x 1.5cm attached with the Patient gave history of intermittent pain third molar (Fig 1,1a). -
Ankylosed Primary Molars, Andlaw (1974) Described Surface Defects from Bicuspids Preceded by Non-Ankylosed 11 Molars
PEDIATRICDENTISTRY/Copyright (~) 1980 The AmericanAcademy of Pedodontics/Vol. 2, No, 1 Ankylosedprimary mola.rs: Results and treatment recommendat,onsfrom an eight-year longitudinal study Louise Brearley Messer,B.D.Sc., L.D.S., M.D.Sc. Jay T. Cline, D.D.S., M.A. Abstract continues concomitantly with vertical alveolar bone growth,~,3 and the tooth is immobile to manual rock- A total of 263 ankyloscd primarymolars in 107 ing.4,5 children aged three to 12 years was studied for four years. Forty-six children remainedin the study for eight years. The etiology of the condition remains unknown. Extrinsic causative factors implicated are local me- Observationof affected dentitions showedthat the con- ~ ~ dition waslikely to recur. Threeclinical pa~ternsfor the chanical trauma, disturbed local metabolism, local- condition are described. Typically, maxillary molars be- ized infection, 6 chemical or thermal irritation 7 and came ankylosed earlier and demonstrated more severe tooth reimplantation, s Intrinsic factors cited include a in[raocclusion than mandibularmolars. Mandibularfirst genetic or congenital gap in the periodontal liga- molars usually remainedslightly or moderatelyin#a- ment. Since both erupting and exfoliating teeth show occluded; mandibularsecond molars and maxillary first alternating periods of resorption and deposition of and second molars showedprogressively severe infra- bone and cementum,° aberrant deposition of these tis- occlusion. Followingeither extraction or ex~oliation of the suesI° may produce an area of ankylosing tissue.Z, affected molars, the succedaneousbicuspids did not differ In a summaryof studies reporting the prevalence of in either coronal morphologyor in distribution of enamel ankylosed primary molars, Andlaw (1974) described surface defects from bicuspids preceded by non-ankylosed 11 molars. -
Maxillary Ameloblastoma: a Review with Clinical, Histological
in vivo 34 : 2249-2258 (2020) doi:10.21873/invivo.12035 Review Maxillary Ameloblastoma: A Review With Clinical, Histological and Prognostic Data of a Rare Tumor ZOI EVANGELOU 1, ATHINA ZARACHI 2, JEAN MARC DUMOLLARD 3, MICHEL PEOC’H 3, IOANNIS KOMNOS 2, IOANNIS KASTANIOUDAKIS 2 and GEORGIA KARPATHIOU 1,3 Departments of 1Pathology and Otorhinolaryngology, and 2Head and Neck Surgery, University Hospital of Ioannina, Ioannina, Greece; 3Department of Pathology, University Hospital of Saint-Etienne, Saint-Etienne, France Abstract. Diagnosis of odontogenic tumors can be neoplasms, diagnosis could be straightforward. In locations challenging due to their rarity and diverse morphology, but outside the oral cavity or when rare histological variants are when arising near the tooth, the diagnosis could be found, suspecting the correct diagnosis can be challenging. suspected. When their location is not typical, like inside the This is especially true for maxillary ameloblastomas, which paranasal sinuses, the diagnosis is less easy. Maxillary are rare, possibly leading to low awareness of this neoplasm ameloblastomas are exceedingly rare with only sparse at this location and often show non-classical morphology, information on their epidemiological, histological and genetic thus, rendering its diagnosis more complicated. characteristics. The aim of this report is to thoroughly review Thus, the aim of this review is to define and thoroughly the available literature in order to present the characteristics describe maxillary ameloblastomas based on the available of this tumor. According to available data, maxillary literature after a short introduction in the entity of ameloblastomas can occur in all ages but later than mandible ameloblastoma. ones, and everywhere within the maxillary region without necessarily having direct contact with the teeth. -
Odontogenic Tumors
4/26/20 CONTEMPORARY MANAGEMENT OF ODONTOGENIC TUMORS RUI FERNANDES, DMD, MD,FACS, FRCS(ED) PROFESSOR UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE- JACKSONVILLE 1 2 Benign th 4 Edition Odontogenic 2017 Tumors Malignant 3 4 BENIGN ODONTOGENIC TUMORS BENIGN ODONTOGENIC TUMORS • EPITHELIAL • MESENCHYMAL • AMELOBLASTOMA • ODONTOGENIC MYXOMA • CALCIFYING EPITHELIAL ODONTOGENIC TUMOR • ODONTOGENIC FIBROMA • PINDBORG TUMOR • PERIPHERAL ODONTOGENIC FIBROMA • ADENOMATOID ODONTOGENIC TUMOR • CEMENTOBLASTOMA • SQUAMOUS ODONTOGENIC TUMOR • ODONTOGENIC GHOST CELL TUMOR 5 6 1 4/26/20 BENIGN ODONTOGENIC TUMORS MALIGNANT ODONTOGENIC TUMORS • PRIMARY INTRAOSSEOUS CARCINOMA • MIXED TUMORS • CARCINOMA ARISING IN ODONTOGENIC CYSTS • AMELOBLASTIC FIBROMA / FIBRO-ODONTOMA • AMELOBLASTIC FIBROSARCOMA • ODONTOMA • AMELOBLASTIC SARCOMA • CLEAR CELL ODONTOGENIC CARCINOMA • ODONTOAMELOBLASTOMA • SCLEROSING ODONTOGENIC CARCINOMA New to the Classification • PRIMORDIAL ODONTOGENIC TUMOR New to the Classification • ODONTOGENIC CARCINOSARCOMA 7 8 0.5 Cases per 100,000/year Ameloblastomas 30%-35% Myxoma AOT 3%-4% Each Ameloblastic fibroma CEOT Ghost Cell Tumor 1% Each 9 10 Courtesy of Professor Ademola Olaitan AMELOBLASTOMA • 1% OF ALL CYSTS AND TUMORS • 30%-60% OF ALL ODONTOGENIC TUMORS • 3RD TO 4TH DECADES OF LIFE • NO GENDER PREDILECTION • MANDIBLE 80% • MAXILLA 20% 11 12 2 4/26/20 AMELOBLASTOMA CLASSIFICATION AMELOBLASTOMA HISTOLOGICAL CRITERIA • SOLID OR MULTI-CYSTIC Conventional 2017 • UNICYSTIC 1. PALISADING NUCLEI 2 • PERIPHERAL 2. REVERSE POLARITY 3. VACUOLIZATION OF THE CYTOPLASM 4. HYPERCHROMATISM OF BASAL CELL LAYER 1 3 4 AmeloblAstomA: DelineAtion of eArly histopathologic feAtures of neoplasiA Robert Vickers, Robert Gorlin, CAncer 26:699-710, 1970 13 14 AMELOBLASTOMA CLASSIFICATION OF 3677 CASES AMELOBLASTOMA SLOW GROWTH – RADIOLOGICAL EVIDENCE Unicystic Peripheral 6% 2% Solid 92% ~3 yeArs After enucleAtion of “dentigerous cyst” P.A . -
Iii Bds Oral Pathology and Microbiology
III BDS ORAL PATHOLOGY AND MICROBIOLOGY Theory: 120 Hours ORAL PATHOLOGY MUST KNOW 1. Benign and Malignant Tumours of the Oral Cavity (30 hrs) a. Benign tumours of epithelial tissue origin - Papilloma, Keratoacanthoma, Nevus b. Premalignant lesions and conditions: - Definition, classification - Epithelial dysplasia - Leukoplakia, Carcinoma in-situ, Erythroplakia, Palatal changes associated with reverse smoking, Oral submucous fibrosis c. Malignant tumours of epithelial tissue origin - Basal Cell Carcinoma, Epidermoid Carcinoma (Including TNM staging), Verrucous carcinoma, Malignant Melanoma. d. Benign tumours of connective tissue origin : - Fibroma, Giant cell Fibroma, Peripheral and Central Ossifying Fibroma, Lipoma, Haemangioma (different types). Lymphangioma, Chondroma, Osteoma, Osteoid Osteoma, Benign Osteoblastoma, Tori and Multiple Exostoses. e. Tumour like lesions of connective tissue origin : - Peripheral & Central giant cell granuloma, Pyogenic granuloma, Peripheral ossifying fibroma f. Malignant Tumours of Connective tissue origin : - Fibrosarcoma, Chondrosarcoma, Kaposi's Sarcoma Ewing's sarcoma, Osteosarcoma Hodgkin's and Non Hodgkin's L ymphoma, Burkitt's Lymphoma, Multiple Myeloma, Solitary Plasma cell Myeloma. g. Benign Tumours of Muscle tissue origin : - Leiomyoma, Rhabdomyoma, Congenital Epulis of newborn, Granular Cell tumor. h. Benign and malignant tumours of Nerve Tissue Origin - Neurofibroma & Neurofibromatosis-1, Schwannoma, Traumatic Neuroma, Melanotic Neuroectodermal tumour of infancy, Malignant schwannoma. i. Metastatic -
Pharmacology of Local Anesthesia
By Mohammad Hussein Zaki Lecturer Oral & Maxillofacial Surgery Faculty of Dentistry – Minia University . Impacted tooth. Failure of the tooth to fully erupt into the oral cavity within its expected developmental time period and can no longer reasonably be expected to do so. A tooth that can not, or will not, erupt into its normal functioning positions. Impacted tooth. An impacted tooth is one that is erupted, partially erupted or unerupted and will not eventually assume a normal arch relationship with the other teeth and tissues. Unerupted tooth. Includes impacted teeth and teeth that are in the process of erupting. Impacted teeth seen in the following order of frequency: 1. Mandibular third molars. 2. Maxillary third molars. 3. Maxillary canine. 4. Mandibular premolar. 5. Maxillary premolar. 6. Mandibular canine. 7. Maxillary central incisors. 8. Maxillary lateral incisors. Systemic factors: • Syndromes. Cleidocranial dysplasia. • Endocrine deficiencies. Hypothyroidism. • Irradiation. Local factors: • Obstruction for eruption. Irregularity in position of an adjacent tooth. Density of the overlying soft tissue or bone. Prolonged deciduous tooth retention. Supernumerary teeth. • Tooth ankylosis. • Dilaceration of roots. • Malposed tooth germs. Local factors: • Pathological lesions. • Cleft lip and palate. • Arch-length deficiency. Phylogenic theory. Mendelian theory. Clinical. Radiographic. • Periapical. Radiographic. • Periapical. Radiographic. • Occlusal. Radiographic. • Panorama. Radiographic. • Panorama. Radiographic. • CT. Radiographic. • CBCT. Impacted teeth other than third molars. Exposure. • A procedure that allows natural eruption of impacted teeth. • It should be done as soon as it is determined that the tooth is not going to erupt spontaneously. • Spontaneous eruption versus orthodontic assistance. Impacted teeth other than third molars. Exposure. Impacted teeth other than third molars. -
Eruption Abnormalities in Permanent Molars: Differential Diagnosis and Radiographic Exploration
DOI: 10.1051/odfen/2014054 J Dentofacial Anom Orthod 2015;18:403 © The authors Eruption abnormalities in permanent molars: differential diagnosis and radiographic exploration J. Cohen-Lévy1, N. Cohen2 1 Dental surgeon, DFO specialist 2 Dental surgeon ABSTRACT Abnormalities of permanent molar eruption are relatively rare, and particularly difficult to deal with,. Diagnosis is founded mainly on radiographs, the systematic analysis of which is detailed here. Necessary terms such as non-eruption, impaction, embedding, primary failure of eruption and ankylosis are defined and situated in their clinical context, illustrated by typical cases. KEY WORDS Molars, impaction, primary failure of eruption (PFE), dilaceration, ankylosis INTRODUCTION Dental eruption is a complex developmen- at 0.08% for second maxillary molars and tal process during which the dental germ 0.01% for first mandibular molars. More re- moves in a coordinated fashion through cently, considerably higher prevalence rates time and space as it continues the edifica- were reported in retrospective studies based tion of the root; its 3-dimensional pathway on orthodontic consultation records: 2.3% crosses the alveolar bone up to the oral for second molar eruption abnormalities as epithelium to reach its final position in the a whole, comprising 1.5% ectopic eruption, occlusion plane. This local process is regu- 0.2% impaction and 0.6% primary failure of lated by genes expressing in the dental fol- eruption (PFE) (Bondemark and Tsiopa4), and licle, at critical periods following a precise up to 1.36% permanent second molar iim- chronology, bilaterally coordinated with fa- paction according to Cassetta et al.6. cial growth. -
Oral Pathology Final Exam Review Table Tuanh Le & Enoch Ng, DDS
Oral Pathology Final Exam Review Table TuAnh Le & Enoch Ng, DDS 2014 Bump under tongue: cementoblastoma (50% 1st molar) Ranula (remove lesion and feeding gland) dermoid cyst (neoplasm from 3 germ layers) (surgical removal) cystic teratoma, cyst of blandin nuhn (surgical removal down to muscle, recurrence likely) Multilocular radiolucency: mucoepidermoid carcinoma cherubism ameloblastoma Bump anterior of palate: KOT minor salivary gland tumor odontogenic myxoma nasopalatine duct cyst (surgical removal, rare recurrence) torus palatinus Mixed radiolucencies: 4 P’s (excise for biopsy; curette vigorously!) calcifying odontogenic (Gorlin) cyst o Pyogenic granuloma (vascular; granulation tissue) periapical cemento-osseous dysplasia (nothing) o Peripheral giant cell granuloma (purple-blue lesions) florid cemento-osseous dysplasia (nothing) o Peripheral ossifying fibroma (bone, cartilage/ ossifying material) focal cemento-osseous dysplasia (biopsy then do nothing) o Peripheral fibroma (fibrous ct) Kertocystic Odontogenic Tumor (KOT): unique histology of cyst lining! (see histo notes below); 3 important things: (1) high Multiple bumps on skin: recurrence rate (2) highly aggressive (3) related to Gorlin syndrome Nevoid basal cell carcinoma (Gorlin syndrome) Hyperparathyroidism: excess PTH found via lab test Neurofibromatosis (see notes below) (refer to derm MD, tell family members) mucoepidermoid carcinoma (mixture of mucus-producing and squamous epidermoid cells; most common minor salivary Nevus gland tumor) (get it out!)