Article Ionizing Radiation Mediates Dose Dependent Effects Affecting the Healing Kinetics of Wounds Created on Acute and Late Irradiated Skin Candice Diaz 1,2, Cindy J. Hayward 1,2, Meryem Safoine 1,2, Caroline Paquette 1,2, Josée Langevin 3, Josée Galarneau 3, Valérie Théberge 4, Jean Ruel 5,6 , Louis Archambault 6,7,8 and Julie Fradette 1,2,6,* 1 Centre de Recherche en Organogénèse Expérimentale de l’Université Laval (LOEX), Québec, QC G1J 1Z4, Canada;
[email protected] (C.D.);
[email protected] (C.J.H.);
[email protected] (M.S.);
[email protected] (C.P.) 2 Department of Surgery, Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada 3 Department of Radiation Oncology, Cégep de Sainte-Foy, Québec, QC G1V 1T3, Canada;
[email protected] (J.L.);
[email protected] (J.G.) 4 Department of Radiation Oncology, Centre Hospitalier Universitaire de Québec–Université Laval, Québec, QC G1R 2J6, Canada;
[email protected] 5 Department of Mechanical Engineering, Faculty of Science and Engineering, Université Laval, Québec, QC G1V 0A6, Canada;
[email protected] 6 Centre de Recherche du CHU de Québec-Université Laval, Québec, QC G1E 6W2, Canada;
[email protected] 7 Department of Physics, Université Laval, Québec, QC G1V 0A6, Canada 8 Centre de Recherche sur le Cancer de l’Université Laval, Québec, QC G1R 2J6, Canada * Correspondence:
[email protected] Citation: Diaz, C.; Hayward, C.J; Abstract: Radiotherapy for cancer treatment is often associated with skin damage that can lead to Safoine, M.; Paquette, C.; Langevin, J.; incapacitating hard-to-heal wounds.