An Evidence-Based Systematic Review of Slimple® by the Natural Standard Research Collaboration

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An Evidence-Based Systematic Review of Slimple® by the Natural Standard Research Collaboration One Davis Square | Somerville, MA 02144 | T: 617.591.3300 | F: 617.758.4274 | www.naturalstandard.com An Evidence-Based Systematic Review of Slimple® By the Natural Standard Research Collaboration SYNONYMS/COMMON NAMES/RELATED SUBSTANCES Slimple®: Achiote leaf, Cassia nomame, chuchuhuasi, citrus bioflavonoids, MaCoca™, glycomacropeptide (GMP), green tea, guggulsterones, lotus leaf extract. Achiote leaf (Bixa orellana L.): Acetate, acetone, achiot (Spanish - Colombia), achiote (Spanish - Peru), achiote seeds, achiotillo, achiotin, arnotta, arnotto (Native American), annatto, annatto extract, annatto tree, annotta, aploppas, apocarotenoids, azo dyes, biche, bija, Bixa acuminata, Bixa acuminata Bojer., Bixa americana, Bixa americana Poiret, Bixa katangensis Delpierre, Bixa odorata, Bixa odorata Ruiz & Pav. ex G. Don., Bixa orellana, Bixa platycarpa, Bixa platycarpa Ruiz & Pav. ex G. Don., Bixa purpurea, Bixa purpurea Hort., Bixa tinctoria, Bixa tinctoria Salixb., Bixa upatensis, Bixa upatensis Grosscurdy, Bixa urucurana, Bixa urucurana Willd., Bixaceae (family), bixin, brickdust, butter color, BXN, carotenoids, calcium sulfate, chalk, changuarica (Spanish - Mexico), colcothar, E160b, E number E160b, eroya, essential oil, false damiana, farinaceous matter, fat-soluble color, fatty acid, fiber, flag annotta, gypsum, ishwarane, jafara, kasujmba-kelling, kham thai, k’u-zub (Spanish - Mexico), lipstick tree, natural color, natural food color, norbixin, occidentalol, occidentalol acetate, ochre, onoto (Spanish - Venezuela), orellana, Orellana americana, Orellana americana Kuntze, Orellana orellana, Orellana orellana (L.) Kuntze, orellin, orleana, Orleanstrauch (German), orucu-axiote, phosphoric acid, potassa, powdered bricks, pumacua (Mexico), red ochre, rocou (Dutch, French), roucou (French - Dominica and the French West Indies), roucouyer, ruku (Hungarian), sand, sand gypsum, silica, spathulenol, starchy bodies, sulfuric acid, terebinthinous body, tomentosic acid, Ultrabix™, unane, urucu (Portuguese - Brazil), urucum (Portuguese), urucu-üva, uruku, water-soluble color, (Z,E)-farnesyl acetate. Cassia nomame: Anthraquinoids, anthraquinones, cássia de empingem (Portuguese (Brazil)), Cassia mimosoides, Cassia mimosoides var. nomame, Cassia nomame, catechins, Chamaecrista mimosoides L., chichani (Marathi), emodic acid, emodin, emodin glycosides, Fabaceae (family), feather-leaved cassia, fish-bone cassia, fiveleaf cassia, glucosides, guaiacol peroxidase, hama cha (Japanese), Japanese tea, kawara-ketumei (Japanese), kita, Leguminosae (family), luteolin, luteolin glucosides, mateloi, mateloi lalahi, mimosoides tea, mountain flat-bean, nemucha (Japanese), nomame, nomame herba, patwa ghas (Hindi), phenols, physcion, sensitiva (Portuguese (Brazil)), Slimple™, tea senna, ukellela chedip (Palauan). Chuchuhuasi (Maytenus krukovii, Maytenus macrocarpa, Maytenus laevis): 3-oxofriedelan-28-oic acid, 3-oxofriedelan-29-oic acid, 4'-methyl-(-)-epigallocatechin, 6-benzoyl-6- deacetylmayteine, 7,8-dihydro-B alpha, 7,8-dihydro-C alpha, 7,8-dihydro-C beta, 7,8-dihydro-D alpha, 7,8- dihydro-D beta, 15-alpha-hydroxy-21-keto-pristimerine, 22-hydroxytingenone, 24(Z)-3- oxodammara20(21),24-dien-27-oic acid, 28,29-dihydroxyfriedelan-3-one, agarofuran sesquiterpenes, canophyllol, catechin tannins, Celastraceae (family), Celastrus macrocarpus, chocha huasha (shipibo- conibo), chu chu huasu, chucchu huashu, chuchasha, chuchuasi, chuchuhuasha, chuchuhuasi, chuchuwasha, chuchuwasha blanca, dammarane-type terpeines, dulcitol, ebenifoline alkaloids, euojaponine alkaloids, One Davis Square | Somerville, MA 02144 | T: 617.591.3300 | F: 617.758.4274 | www.naturalstandard.com friedelane-type triterpenes, Haenkea macrocarpa, Haenkea multiflora, isoxuxuarines B alpha, isoxuxuarines B beta, krukovine A, krukovine B, krukovine triterpenes, laevisine alkaloids, macrocarpin triterpenes, macrocarpins, makrocarpine, maytansine, mayteine, maytenin, maytenoic acid, Maytenus boaria, Maytenus chuchuhuasca, Maytenus colasii, Maytenus diversifolia, Maytenus ebenifolia, Maytenus guyanensis, Maytenus krukovii, Maytenus laevis, Maytenus macrocarpa, Maytenus multiflora, Maytenus terapotensis, mebeverine, octa-nor-13-hydroxydammara-1-en-3,17-dione, ouratea-proanthocyanidin A, ouratea-proanthocyanidin B, phenoldienones, pristimeran, pristimerin, proanthocyanidins, sesquiterpenes, Slimple™, tingenone, triterpenes, xuxuá, xuxuasin A, xuxuasin B. Note: The name “catuaba” may be used for the infusions of the bark of several trees that are native to Brazil. The most widely used barks are derived from the trees Trichilia catigua and Erythroxylum vacciniifolium; however, “catuaba” may also refer to the bark of Maytenus species. Catuaba is a remedy common in Brazilian folk medicine. Maytenus spp. may be found around the world and may be used in a variety of traditional medicine systems. This monograph, however, will focus on Maytenus spp. from South America that are more commonly associated with chuchuhuasi. According to review, several different species may be referred to as “chuchuhuasi,” which may cause a modicum of confusion {Gonzalez, 2000, No pmid}. In addition to Maytenus macrocarpa, Maytenus species that are generally used as chuchuhuasi may also include, but may not be limited to, Maytenus krukovii (Maytenus chuchuhuasha) and Maytenus laevis, and occasionally Maytenus colasii (Salacia colasii) {Gonzalez, 2000, No pmid}. Other species that have been associated with chuchuhuasi include Maytenus ebenifolia, Maytenus boaria, and Maytenus guyanensis (secondary sources). Typically, however, Maytenus macrocarpa, Maytenus krukovii (Maytenus chuchuhuasha), and Maytenus laevis are the more widely accepted species for chuchuhuasi. Some secondary sources cite that Maytenus ilicifolia is used as chuchuhuasi; however, expert opinion indicates that this species should not be associated with chuchuhuasi. This monograph focuses on Maytenus macrocarpa, Maytenus krukovii (Maytenus chuchuhuasha), and Maytenus laevis, in addition to Maytenus ebenifolia, Maytenus boaria, Maytenus guyanensis, and to a lesser extent, Maytenus colasii. Citrus bioflavonoids (hesperidin): 3',5,7-trihydroxy-4-methoxyflavanone 7-rhamnoglucoside, 3',5,7-trihydroxy-4'-methoxyflavanone 7- rhamnoglucoside, 3',5,7-trihydroxyflavanone 7-rhamnoglucoside, 3',5,9-dihydroxy-4'-methoxy-7-O- rutinosyl flavanone, 5,7, 3'-trihydroxy-4'-methoxy-flavanone 7-rhamnoglucoside, α-glucosylhesperidin, bioflavonoid, citrus flavonoids, Dangyooja (Citrus grandis Osbeck), flavanone, flavonoid glycosides, flavonoids, G-hesperidin, glucosyl hesperidin, hesperidin, hesperidin-7-O-rutinoside, hesperidin-7- rhamnoglucoside, hesperidin-7-rutinose, hesperidin-7-rutinoside, hesperidin glycoside, hesperidin methyl chalcone (HMC), hesperidine methylchalcone, Kjool (Citrus unshiu Marcow), micronized purified flavonoid fraction, MPFF, neohesperidin, vitamin P, trimethyl-hesperidin-chalkon, yuza (Citrus junos Sieb ex Tanaka). 5682 SE, Alvenor®, Ardium®, Arvenum 500®, Capiven®, Daflon® 500mg, Detralex®, Elatec®, S 5682, Venotec®, Rikkunshito, Slimple™,Venitol®: micronized purified flavonoid fraction that contains diosmin and flavonoids (hesperidin, isorhoifolin, linarin, disometin) expressed as hesperidin; Cyclo 3 Fort®, Great Legs: Ruscus aculeatus root extract + hesperidin methyl chalcone, and <ref id=”vitaminc”>ascorbic acid</ref>. Glycomacropeptide (GMP): Acetyl galactosamine, branched chain amino acids (BCAAs), carbohydrate, casein-derived peptide (CDP), casein glycomacropeptide (cGMP), casein glycopeptide (CGP), casein macropeptide (CMP), caseinglycopeptide, caseinmacropeptide, caseinoglycomacropeptide, cheese, cholecystokinin (CCK), One Davis Square | Somerville, MA 02144 | T: 617.591.3300 | F: 617.758.4274 | www.naturalstandard.com galactosamine, galactose, glucosamine, isoleucine, kappa-casein, milk, phosphorus, sialic acid (N- acetylneuraminic acid), Slimple™, sweet whey, valine, whey. Green tea (Camellia sinensis): (-)-epigallocatechin, anthocyanins, Árbol del té (Spanish), arbre à thé (French), caffeine, čaj (Czech, Russian, Slovenian), čaje zelené (Czech), čajnoe derevo (Russian), čajovník čínský (Czech), camellia, Camellia assamica, Camellia sinensis, Camellia sinensis (L.) Kuntze, camellia tea, Camellia thea, Camellia theifera, catechins, çay (Turkish), cha (Chinese, Thai, Japanese, Korean, Sinhalese, Urdu), chá (Portuguese - Brazil), cha no ki (Japanese), chaa (Hindi), chaay (Hindi, Sinhalese), chá-da-Índia (Portuguese), chaha (Kannada), chai (Hindi, Russian), Chainoe derevo (Russian), chá-preto (Brazilian), chay (Persian, Urdu), chaya (Tamil), Chinese rea, Chinesischer Thee (German), chiya (Nepali), EGC, EGCG, epicatechin gallate, epicatechins, epigallocatechin, epigallocatechin-3-gallate, green tea extract, GTE, herbata chińska (Polish), hiina teepõõsas (Estonian), ichibi (Japanese), Japanese tea, kamelia (Polish), lignin, lotus-f3, L-theanine, matcha, matcha green tea, matsu-cha tea, methylxanthine, nok cha (Korean), O-methylated catechin, organic acids, phenolic acids, phytochemicals, pianta del tè (Italian), planta del té (Spanish), Poly E, polyphenols, Polyphenon E®, proanthocyanidins, shay (Arabic), sinecatechins, te (Danish, Kannada, Norwegian, Sinhalese, Swedish), Slimple™, tannins, té (Spanish), tea (Hungarian), tea green, tebusk (Danish), tebuske (Swedish), tee (Finnish, German), teekameelia (Estonian), teepensas (Finnish), teestrauch (German), teestruik (Dutch), teh (Hebrew, Malay), teyaku (Telugu), thayilai (Tamil), the (French),
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