SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition
Version: 1.0 Creation Date: Feb. 6, 2018 Revision Date: Feb. 6, 2018 1. Identification 1.1 GHS Product identifier Product name Cyclohexanone oxime 1.2 Other means of identification Product number A606108 Other names N-cyclohexylidenehydroxylamine 1.3 Recommended use of the chemical and restrictions on use Identified uses Used for research and development only.Intermediates Uses advised against no data available 1.4 Supplier's details Company Sangon Biotech (Shanghai) Co., Ltd. Address 698 Xiangmin Road, Songjiang, Shanghai 201611, China Telephone +86-400-821-0268 / +86-800-820-1016 Fax +86-400-821-0268 to 9 1.5 Emergency phone number Emergency phone +86-21-57072055 number Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). 2. Hazard identification 2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 4 2.2 GHS label elements, including precautionary statements Pictogram(s)
Signal word Warning
Cyclohexanone oxime Page 1 of 8 Hazard statement(s) H302 Harmful if swallowed Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. Response P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. Storage none Disposal P501 Dispose of contents/container to ... 2.3 Other hazards which do not result in classification
no data available 3. Composition/information on ingredients 3.1 Substances
Common names and CAS EC Chemical name Concentration synonyms number number Cyclohexanone Cyclohexanone oxime 100-64-1 202-874-0 ≥98% oxime 4. First-aid measures 4.1 Description of necessary first-aid measures General advice
Medical attention is required. Consult a doctor. Show this safety data sheet (SDS) to the doctor in attendance. If inhaled
Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical. Following skin contact
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor. Following eye contact
Rinse with pure water for at least 15 minutes. Consult a doctor. Following ingestion
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately. 4.2 Most important symptoms/effects, acute and delayed
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides.
Cyclohexanone oxime Page 2 of 8 4.3 Indication of immediate medical attention and special treatment needed, if necessary
no data available 5. Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing media
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. 5.2 Specific hazards arising from the chemical
Flash point data for this chemical are not available; however, it is probably combustible. 5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary. 6. Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours. Avoid contacting with skin and eye. Use personal protective equipment. Wear chemical impermeable gloves. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. 6.2 Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. 6.3 Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations. 7. Handling and storage 7.1 Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam. 7.2 Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials. 8. Exposure controls/personal protection 8.1 Control parameters Occupational Exposure limit values
Cyclohexanone oxime Page 3 of 8 Component Cyclohexanone oxime CAS No. 100-64-1 Limit value - Eight hours Limit value - Short term ppm mg/m³ ppm mg/m³ Latvia 10 Remarks
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area. 8.3 Individual protection measures, such as personal protective equipment (PPE) Eye/face protection
Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US). Skin protection
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator. Thermal hazards
no data available 9. Physical and chemical properties Physical state Solid. Colour - Odour no data available Melting point/ freezing 89.05 °C. Remarks:No more information available from this point data source. Boiling point or initial >= 206 - <= 210 °C. Remarks:No more information available boiling point and boiling from this data source. range Flammability no data available Lower and upper no data available explosion limit / flammability limit Flash point 79°C(lit.) Auto-ignition no data available temperature Decomposition no data available temperature pH no data available Kinematic viscosity no data available
Cyclohexanone oxime Page 4 of 8 Solubility less than 1 mg/mL at 20°C Partition coefficient n- Pow = 18.4. Temperature:25 °C.;log Pow = 1.265. octanol/water Temperature:25 °C. Vapour pressure 1.78 Pa. Temperature:20 °C. Density and/or relative 1.087 g/cm³. density Relative vapour density 3.91 (Relative to Air) Particle characteristics no data available 10. Stability and reactivity 10.1 Reactivity
no data available 10.2 Chemical stability
no data available 10.3 Possibility of hazardous reactions
CYCLOHEXANONE OXIME reacts violently with fuming sulfuric acid at temperatures > 150°C. . Several explosions or violent decompositions have occurred during distillation of aldoximes, which may be attributable to the formation of peroxides of various types. This is especially the case in the presence of acid, Chem. Eng. News, 1974, 52(35), 3. A nickel catalyzed aldoxime rearrangement to an amide, went out of control after changing the solvent employed, J. Loss Prev., 1993, 6(2), 69. 10.4 Conditions to avoid
no data available 10.5 Incompatible materials
no data available 10.6 Hazardous decomposition products
no data available 11. Toxicological information Acute toxicity
Oral: LD50 - rat (male) - 1 765.01 mg/kg bw. Remarks:Acc. to study report: data obtained excluding the results of the 1000 mg/kg group; including this group the LD50 was 1758.94 (95% CI: 1374.74-2250.52) mg/kg. Inhalation: no data available Dermal: approximate LD50 - rabbit (male/female) - > 5 000 mg/kg bw.
Skin corrosion/irritation
no data available Serious eye damage/irritation
no data available Respiratory or skin sensitization
no data available
Cyclohexanone oxime Page 5 of 8 Germ cell mutagenicity
no data available Carcinogenicity
no data available Reproductive toxicity
no data available STOT-single exposure
no data available STOT-repeated exposure
no data available Aspiration hazard
no data available 12. Ecological information 12.1 Toxicity
Toxicity to fish: LC50 - Pimephales promelas - 208 mg/L - 96 h. Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - 22 mg/L - 48 h. Toxicity to algae: EC50 - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - 18.24 mg/L - 72 h. Toxicity to microorganisms: EC50 - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - 18.24 mg/L - 72 h. 12.2 Persistence and degradability
no data available 12.3 Bioaccumulative potential
no data available 12.4 Mobility in soil
no data available 12.5 Other adverse effects
no data available 13. Disposal considerations 13.1 Disposal methods Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems. Contaminated packaging
Cyclohexanone oxime Page 6 of 8 Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials. 14. Transport information 14.1 UN Number ADR/RID: UN3271 IMDG: UN3271 IATA: UN3271 14.2 UN Proper Shipping Name ADR/RID: ETHERS, N.O.S. IMDG: ETHERS, N.O.S. IATA: ETHERS, N.O.S. 14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3 14.4 Packing group, if applicable ADR/RID: II IMDG: II IATA: II 14.5 Environmental hazards ADR/RID: no IMDG: no IATA: no 14.6 Special precautions for user
no data available 14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available 15. Regulatory information 15.1 Safety, health and environmental regulations specific for the product in question
Chemical name Common names and synonyms CAS number EC number Cyclohexanone oxime Cyclohexanone oxime 100-64-1 202-874-0 European Inventory of Existing Commercial Chemical Substances Listed. (EINECS) EC Inventory Listed. United States Toxic Substances Control Act (TSCA) Inventory Listed. China Catalog of Hazardous chemicals 2015 Not Listed. New Zealand Inventory of Chemicals (NZIoC) Listed. Philippines Inventory of Chemicals and Chemical Substances Listed. (PICCS) Vietnam National Chemical Inventory Not Listed.
Cyclohexanone oxime Page 7 of 8 Chinese Chemical Inventory of Existing Chemical Substances (China Listed. IECSC) 16. Other information Information on revision Creation Date Feb. 6, 2018 Revision Date Feb. 6, 2018 Abbreviations and acronyms
CAS: Chemical Abstracts Service ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road RID: Regulation concerning the International Carriage of Dangerous Goods by Rail IMDG: International Maritime Dangerous Goods IATA: International Air Transportation Association TWA: Time Weighted Average STEL: Short term exposure limit LC50: Lethal Concentration 50% LD50: Lethal Dose 50% EC50: Effective Concentration 50%
References
IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/ eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index? pageID=0&request_locale=en CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
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