Use of High Throughput Assays and Computational Tools; Endocrine Disruptor Screening Program; Notice of Availability and Opportunity for Comment’’

NRDC EPA-HQ-OPPT-2015-0305 August, 2015

Comments from the Natural Resources Defense Council

On The Document Titled, ‘‘Use of High Throughput Assays and Computational Tools; Endocrine Disruptor Screening Program; Notice of Availability and Opportunity for Comment’’

To the U.S. Environmental Protection Agency Docket No. EPA-HQ-OPPT-2015-0305

August 18, 2015

Background

The Natural Resources Defense Council ("NRDC") is a national, non-profit environmental organization of lawyers, scientists, and other professionals. NRDC presents these comments on behalf of our 1.4 million members and online activists. NRDC does not have any financial interest in the topic of these comments.

The endocrine system utilizes highly complex, tightly controlled molecular processes for its optimal functioning in the body. The proper balance of hormones can be synchronized in a variety of ways (including direct protein binding, epigenetic alterations, gene activation and silencing), and is essential across the entirety of the life course. Small changes in the perfectly orchestrated symphony of hormone levels can severely disrupt the harmony necessary for critical windows of development (e.g., fetal development, infanthood, childhood, and adolescence), leaving the body vulnerable to a host of negative health outcomes (such as diabetes, cancer, obesity, and reproductive dysfunction).

The last decade has seen an exponential increase in the development of computational, biological, and chemical tools capable of increasing both the number of chemicals analyzed and the pace of chemical toxicity evaluation. These tools, including the EPA Toxicity Forecaster (ToxCast™) and the National Institute of Environmental Health Sciences (NIEHS) Tox21 platforms, have the potential to rapidly generate molecular and cellular data for thousands of chemicals at once, and provide an additional stream of useful information that can aide in regulatory decision-making.

A program that evaluates chemicals for their ability to disrupt the endocrine system (also known as endocrine disrupting chemicals or EDCs) must be both protective and productive to sufficiently

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safeguard the health of the public. To be productive, the program must test and identify high priority EDCs as quickly as possible and prohibit them from entering or remaining in commerce. To be protective, the program must minimize the number of potentially harmful chemicals that are missed via testing and screening procedures (protect against false negatives).

Created in response to the mandate in the 1996 Food Quality Protection Act, the Endocrine Disruptor Screening Program (EDSP) was established by the EPA to identify chemicals that could negatively impact the endocrine systems of humans and wildlife. In nearly 20 years since it was conceived of in the law, no chemical has been fully evaluated and regulated as a result of the EDSP, and thus the program has not been protective or productive.

Unfortunately, EPA’s request for comments on the use of high throughput assays and computational tools in the Endocrine Disruptor Screening Program does not address the lack of protection and productivity of the program. In fact, the proposal could exacerbate the flaws – especially the lack of protectiveness in the EDSP - by relying on a model that produces an unacceptably high rate of false negatives, does not evaluate all known relevant biological pathways1, and has the potential to miss chemicals that could adversely impact large subsets (e.g., developing fetuses, infants, and children) of our population.

In the comments presented below, we will outline both the deficiencies in the agency's proposed use of emerging technology, as well as offer possible alternative ways to more fully and effectively utilize emerging data streams to protect public health. Our comments will be presented in two parts. First, to be responsive to the agency request for comments on the use of the ToxCast™ “ER Model” as an alternative to the uterotrophic, ER binding, and ER transactivation (ERTA) EDSP Tier 1 assays, we will provide a technical critique of the “ER Model” and its uses. Second, we will provide recommendations for the use of emerging sources of data (including ToxCast™) to help increase the productivity and public health protective ability of the EDSP.

NRDC does not support the use of the ToxCast™ “ER Model” as an alternative to the uterotrophic, ER binding, or ER transactivation Tier 1 assays.

After extensive review of the scientific literature and background material provided with the FR notice, NRDC does not support the use of the “ER Model” as a replacement for the uterotrophic, ER binding, and ERTA EDSP Tier 1 assays2. We are very concerned with the inability of the “ER Model” to identify

1 Pathway-based approaches could be useful for evaluating the toxicity of chemicals that act via known molecular cascades, but can be unprotective when used to evaluate the toxicity of chemicals with unknown and/or multiple ways to disrupt a cellular process. For example, chemicals can act via different pathways depending upon the organ exposed (e.g., tamoxifen inhibits cell proliferation in breast cancer cells but can stimulate proliferation in the uterus). Large-scale efforts aimed at identifying the toxicity of large pools of chemically and physically distinct environmental chemicals should, therefore, not limit themselves by relying solely on overly simplified pathway- based models to identify and characterize chemical hazard and/or risk. 2 Though there are well-documented issues with the specificity and sensitivity of the uterotrophic, ER binding, and ERTA EDSP Tier 1 assays, these assays are part of a more robust battery of tests. Replacing three tests in a larger battery with a single approach (e.g., the “ER Model”) requires a high level of confidence (and low level of

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chemicals with well-established estrogenic activity (i.e., the model has too high a false negative rate), the limited statistical characterization and transparency of the model, and the overreliance on a narrowly focused pathway-based model that is populated with data from a convenience sample of high- throughput assays3. We are also troubled by the agency’s disregard of the FIFRA Scientific Advisory Panel (SAP) recommendations4 to forgo replacement of the uterotrophic assay with the “ER Model” without further testing.

A. Limitations in the “ER Model” preclude it from replacing the EDSP Tier 1 uterotrophic assay.

There are at least four limitations in the ToxCast™ “ER Model” that prohibit its use as a replacement for the in vivo uterotrophic assay. First, as noted by the FIFRA SAP in its review of the “ER Model,”5 the inability of in vitro assays to detect or account for altered chemical behavior due to biological processes such as metabolism and absorption severely limits the model’s ability to predict toxicity in whole animal systems. Chemical toxicity can change when a substance is bound to biomolecules or broken down by metabolism in the body. Cell-free and cell-based assays that lack metabolic capabilities, like those used in the ToxCast™ platform, could therefore miss toxicity that would otherwise occur in an intact living system (e.g., a human body).

Second, the pathway modeled by EPA is merely a proxy for actual biological activity, and represents only one possible way in which estrogenic compounds can disrupt cellular processes. Chemicals can perturb estrogen signaling via genomic and non-genomic pathways, and can act as agonists (substances that turn on a signaling pathway) or antagonists (substances that turn off a signaling pathway). By evaluating only nuclear receptor-mediated (genomic) agonist behavior, the “ER Model” will miss chemicals that that interfere with normal estrogen signaling processes by other mechanisms, significantly reducing the usefulness of the model to identify estrogenic chemicals.

Third, when compared to guideline and guideline-like studies, the “ER Model” demonstrated abysmal detection of estrogenic chemicals. The model missed nearly 30 percent (15/556) of the

uncertainty) in the ability of the replacement approach to identify endocrine disrupting chemicals. The “ER Model” fails to meet this basic threshold. 3 The assays used in ToxCast™ were assembled from existing, “off-the-shelf” assays that could be purchased and/or resourced out (performed in contract labs) by EPA. The ToxCast™ assays were not designed to specifically test for activity on the proposed ER pathway. EPA’s approach is in stark contrast to that taken by NIEHS in their Tox21 program. As opposed to developing a “pathway-based model” to fit readily available assays, the Tox21 approach seeks to map biologically-relevant pathways first, then develop or modify assays to measure pathway-specific responses. By building a model to fit the available assays, the EPA approach is akin to forcing round pegs (biological mechanism) to fit into square holes (available assays). 4 FIFRA Scientific Advisory Panel (2015). Transmittal of Meeting Minutes of the FIFRA Scientific Advisory Panel Meeting held on “Integrated Endocrine Bioactivity and Exposure-Based Prioritization and Screening.” 5 Referred to as the “AUC Model” in footnote 4. 6 For this discussion, false negatives include chemicals that were incorrectly identified as not having estrogenic activity and those with “inconclusive” results.

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in vivo estrogenic reference chemicals7 from guideline-like studies and 3 percent (1 out of 30 chemicals) of estrogenic reference chemicals from guideline studies.8 The lack of sensitivity (high false negative rate) of the “ER Model” for in vivo studies is extraordinarily problematic and leads to decreased confidence in the ability of the model to identify chemicals that could disrupt estrogen signaling pathways in whole animal (including human) systems.

Fourth, the score derived from the “ER Model” (the area under the curve, or AUC score) utilizes relatively arbitrary cutoffs that have not been adequately validated using a diverse array of in vivo assays. In not recommending the “ER Model” be used as a substitute for the uterotrophic Tier 1 assay, the FIFRA SAP voiced concern over the model performance for chemicals with low or moderate estrogenicity. To overcome this deficiency in the model, the expert panel of scientists on the FIFRA SAP suggested that the agency demonstrate the predictive ability of the model by comparing model results to 1) new, targeted uterotrophic assays for chemicals with moderate to low estrogenic activity and 2) other in vivo EDSP Tier 1 tests for estrogen activity (e.g., rat pubertal). There is no evidence in the public record that the agency has performed these recommended additional tests, thus rendering the results from the “ER Model” for low to moderate estrogenic compounds uncertain and unreliable.

The inability of the “ER Model” to measure and account for metabolic activity, the overreliance on a single pathway/mode of action, the critically high false negative rate, and the lack of additional data to demonstrate model performance for low and moderate estrogenic compounds renders the “ER Model” an unacceptable replacement for the EDSP Tier 1 uterotrophic assay.

B. Limitations in the “ER Model” preclude it from replacing the EDSP Tier 1 ER binding and ERTA assays.

Adding to the metabolic, pathway, and predictive capacity limitations discussed above (in the uterotrophic assay limitations section), the “ER Model” has several additional limitations that prohibit its use as a replacement for the EDSP Tier 1 ER binding and ERTA assays. First, as noted in the FIFRA SAP minutes,9 there are several unclear and non-transparent aspects of the model that limit the confidence in model results. For example, it is unclear why an unweighted model with underlying linearity assumptions10 and a penalized least-squares approach11 was chosen to

7 Estrogenic in vivo reference chemicals missed by the “ER Model” include methylparaben, triclosan, reserpine, permethrin, octamethylcyclotetrasiloxane, and gibberellic acid. Inconclusive chemicals cannot be specifically listed due to coded identities in footnote 8. 8 Browne, P., Judson, R. S., Casey, W., Kleinstreuer, N., & Thomas, R. S. (2015). Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model. Environmental Science & Technology, 150612115349008. http://doi.org/10.1021/acs.est.5b02641 9 See footnote 4. 10 The “ER Model” assumes that the signal from an assay is directly related to a signal from the receptor. The linearity is a function of model performance, not the shape of the dose-response curve. 11 A penalized least squares method is a statistical tool for removing the roughness of the line when fitting different data points together – it smooths the curve. As noted in footnote 4, model results are strongly

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represent ER activity. A model that assumes perfect alignment of assay responses and receptor activity seems unlikely to be accurate or reliable given that variations can occur across different assay types (e.g., cell-free versus cell-based), cell types (e.g., breast, uterine, and liver carcinoma cell lines), cell origins (e.g., mouse, human, bovine), endpoints (e.g., receptor-binding, receptor dimerization, cell proliferation), and assay sensitivities.12 Also, without publically disclosed sensitivity analysis of the weighting, penalty term, and model structure (e.g., linear versus non- linear), it is impossible for the public and the scientific community to evaluate the ability of the model to sufficiently identify estrogenic compounds. For the public to more fully embrace the use of emerging biological and computational methods as a decision-making tool, the agency must make transparency (including assay performance and specificity13, model assumptions, key terms/concepts, and decision criteria14), particularly for its statistical models, one of its highest priorities.

Second, the “ER Model” is severely limited by its unacceptably low sensitivity (false negative rate) in vitro. For the in vitro reference chemicals, 11 percent (3 out of 28 chemicals15) were inaccurately identified as non-estrogenic compounds, with 2 of the 3 chemicals mistakenly identified as having no activity at all according to the model.16 For chemical screening, the final report of the Endocrine Disruptor Screening and Testing Advisory Committee17 recommended that Tier 1 assays “be more ‘sensitive’ than they are ‘specific,’ meaning that they should have as their primary objective the minimization of false negative or (Type II) errors, while permitting an as-of-yet undetermined, but acceptable, level of false positive or (Type I) errors”.18 The failure of the “ER Model” to accurately identify the estrogenic reference chemicals renders the model inadequate to protect the health of populations.

influenced by the penalty term used, with the outcome of the model moving closer to zero (in this case, no estrogenic effect) as the penalty term changes. In the case of the “ER model” the penalty term is used to decrease the value of model solutions (e.g., AUC scores) that predict chemicals to be promiscuous (i.e., interacting with more than one receptor in the model). 12 Dreier, D. a., Connors, K. a., & Brooks, B. W. (2015). Comparative endpoint sensitivity of in vitro estrogen agonist assays. Regulatory Toxicology and Pharmacology, 72(2), 185–193. http://doi.org/10.1016/j.yrtph.2015.04.009 13 To our knowledge, QA/QC statistics and assay specificity have not been publically released for any of the ToxCast assays. From what we can discern from public presentations made by the agency (e.g., ToxCast data summit), many of the assays used in ToxCast™ rely heavily upon immortalized cell lines. Cell lines can be susceptible to a variety of environmental (e.g., vapor pressure, temperature) and experimental (e.g., culture methods) variations, making QA/QC information essential for proper evaluation of resultant data. 14 For example, the biological rationale for choosing 0.1 as the activity threshold for the “ER Model”. 15 Estrogenic in vitro reference chemicals missed by the “ER Model” include di-n-butyl phthalate (DBP), diethylhexyl phthalate (DEHP) and dicofol. 16 See footnote 8. 17 The federal advisory committee made up of representatives from government, industry, worker safety groups, academia, and public health and environmental groups, tasked with developing consensus-based recommendations for a screening program capable of providing information on the endocrine effects of chemicals for EPA regulatory decision-making. 18 U.S. Environmental Protection Agency. (1999) Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) Final Report; at chapter 7, pg. 2-3.

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A third limitation of the “ER Model” for use as replacement for the ER binding and ERTA Tier 1 assays is the lack of clarity on whether both agonist and antagonist information will be measured. While the EPA White Paper19 for the December 2014 FIFRA SAP meeting analyzes both agonist and antagonist modes (with the panel members noting that model performance for antagonist mode is slightly weaker than that for agonist mode20), the Browne, et al21 analysis was limited to agonism only. It is, therefore, unclear as to whether EPA intends to use the “ER Model” solely for the detection of agonists or if the model will also be used for antagonists. Given the ability of the ToxCast™ assays to detect both agonism and antagonism, EPA should evaluate both types of activity when assessing model performance.

The combination of high false negative rates, unclear and unlikely model structure/performance, lack of clarity on endpoint behavior to be assessed (i.e., agonist versus antagonist), the lack of metabolic competency, and an overly constrained pathway-based model design, make the “ER Model” an unfit replacement for the ER binding and ERTA EDSP Tier 1 assays.

Given the severe limitations of the “ER Model” for the uterotrophic, ER binding, and ERTA Tier 1 assays, it is deeply disturbing and highly problematic that the agency staff has already publically stated in its published article that the “EPA is accepting ToxCast™ ER model data for 1812 chemicals as alternatives for EDSP Tier 1 ER binding, ER transactivation, and uterotrophic assays.”22 This statement strongly suggests this Federal Register notice is merely a rubber stamp of decisions already made. The public, including the broader scientific community, deserves to have the agency consider and address their questions, concerns, and criticisms of new methods that could significantly alter the course of chemical toxicity testing - before official conclusions impacting regulatory decisions are reached.

NRDC recommendations for the use of emerging sources of data to help increase the productivity and public health protective ability of the Endocrine Disruptor Screening Program (EDSP).

The EDSP currently utilizes a two-tiered screening and testing system as a decision-support tool for making a “statutory determination of whether a particular substance ‘may have an effect in humans that is similar to an effect produced by a naturally occurring [hormone]’ (21 U.S.C. 346a(p)).” 23 The first tier of the screening and testing program (Tier 1) involves the use of a battery of validated in vitro24 and

19 U.S. Environmental Protection Agency (2014). Integrated Bioactivity and Exposure Ranking : A Computational Approach for the Prioritization and Screening of Chemicals in the Endocrine Disruptor Screening Program FIFRA SAP December 2-5 , 2014. 20 See footnote 4, pp. 11 and 23. 21 See footnote 8. 22 See footnote 8. 23 Endocrine Disruptor Screening Program; Proposed Statement of Policy, 63 Fed. Reg. 71,542 (Dec. 28, 1998). 24 In vitro EDSP Tier 1assays include estrogen receptor binding in rat uterine cytosol, estrogen receptor transcriptional activation in a human cervical carcinoma cell line, androgen receptor binding in rat prostate cytosol, steroidogenesis in a human adenocarcinoma cell line, and aromatase activity in human microsomes.

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in vivo25 assays to detect androgen-, estrogen-, and thyroid-mediated effects (Figure 1). The second tier (Tier 2) utilizes in vivo tests to quantify dose-response relationships and identify adverse outcomes across different taxa. For a chemical to advance to the next tier, a weight-of-evidence evaluation must provide sufficient proof that a chemical is likely to have endocrine disrupting potential.

Figure 1. Diagram of the two-tiered EDSP testing protocol. Chemicals from the 10,000 chemical EDSP universe are prioritized using chronological (time until next pesticide review) or biological (e.g. relevant in vitro and in vivo tests) means. Weight of evidence evaluations determine movement between the tiers. NRDC proposes that ToxCast data be used in prioritization and evidence integration/weight of evidence evaluations (shown in italics).

Though NRDC does not support the use of the “ER Model” to evaluate chemicals in the EDSP, we are supportive of using emerging streams of toxicological data for screening purposes (prioritization for the Tier 1 battery) and as additional streams of information (in the evidence integration/weight-of-evidence determination) for the program. Despite the model-specific limitations mentioned in the previous section, the ability of ToxCast™ and similar platforms (such as Tox21) to increase the breadth of chemical coverage, the depth of mechanistic understanding, and the speed/efficiency of chemical testing, make them valuable tools for identifying chemicals that can interfere “with the production, release, transport, metabolism, binding, action or elimination of natural hormones in the body responsible for the maintenance of homeostasis and the regulation of developmental processes.”26

25 In vivo EDSP Tier 1 assays include the rat uterotrophic, Hershberger, pubertal female, and pubertal male assays, and the amphibian (frog) metamorphosis and fish short-term reproduction assays. 26 EPA definition of an endocrine disruptor as defined by Kavlock, 1996; Kavlock, R. J., Daston, G. P., DeRosa, C., Fenner-Crisp, P., Gray, L. E., Kaattari, S., … Tilson, H. A. (1996). Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop. Environmental Health Perspectives, 104 Suppl 4(August), 715–740. http://doi.org/10.1289/ehp.96104s4715

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In lieu of the more problematic, indirect, and unnecessary “ER Model” for prioritization, the agency should investigate the use of simpler, more inclusive, pathway-free approaches that use bioactivity ranges derived from ToxCast™ assay replicates27 to prioritize chemicals for Tier 1 testing. Chemical ranking could be based upon a combination of multiple endpoints (e.g., estrogen receptor, androgen receptor, thyroid receptor, steroidogenesis) and could rely on easily attainable metrics such as the total number of active assays or the lowest activity concentrations (e.g., AC5, AC10, or AC50 values) across all assays to set testing priorities.

To test whether or not a pathway-free approach would perform similarly or better to a pathway-based approach, NRDC performed a qualitative analysis using EPA-processed ToxCast™ activity calls28 and 29 30 AC50 values for estrogen receptor α and β (see Figure 2) .

Figure 2. NRDC data processing and analysis scheme for ranking EDSP chemicals in a pathway-free format.

First, we downloaded the processed, assay-specific ToxCast™ data from the iCSS dashboard. Second, we reorganized the data in a by chemical format instead of the by assay format of the iCSS downloaded data. Next, we summed the total number of ER assays that were active for each chemical and identified the lowest AC50 score across all assays. Finally, we ranked the chemicals by a normalized “potency factor” (the lowest AC50 divided by the total number of active assays) and qualitatively compared the results to the “ER Model” AUC scores.31

Comparing the pathway-free versus ER model-based results, several notable findings emerge. First, both methods prioritize strong agonist chemicals highly in their ranking (i.e., chemicals with strong agonist activity appear within the top-ranked chemicals on each list; see Table 1). This means that both pathway-free and pathway-based approaches are capable of identifying chemicals with strong estrogenic activity.

27 Based on recommendation from December 2014 FIFRA SAP. In the meeting minutes, the panel suggested that data from each assay replicate be used to generate several curves that could correspond to a range of bioactivity values. 28 EPA determines a chemical as active in an assay by fitting raw data to several curve types (e.g., Hill, gain-loss, or constant) and determining the best fitting curve using Akaike Information Criteria. This curve-fitting method introduces uncertainty into the assignment of activity (i.e., active or inactive), and may result in discordant assignment of activity depending upon statistical models employed. 29 AC50 values are the concentration that results in 50 percent activity in a given assay. AC50 values are related to chemical potency. 30 Data download for gene symbols ESRA and ESRB from iCSS dashboard on August 10, 2015. Data processed via the ToxCast data analysis pipeline (see http://www.epa.gov/nheerl/comptox/toxcast/files/MySQL%20Database/Pipeline_Overview.pdf) for more details on data processing, and are available via the Interactive Chemical Safety for Sustainability (iCSS) dashboard at http://actor.epa.gov/actor/faces/CSSDashboardLaunch.jsp 31 Standards from footnote 8 and Huang, R., Sakamuru, S., Martin, M. T., Reif, D. M., Judson, R. S., Houck, K. a, … Xia, M. (2014). Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. Scientific Reports, 4, 5664. http://doi.org/10.1038/srep05664

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Table 1. Comparison of pathway-free and pathway-based (“ER Model”) approaches to chemical

prioritization.

ER ER

™

ER ER assays

/total number number /total

™

assays

free (normalized (normalized free

ER agonist ER agonist

active assays) active

potency) rank potency)

Chemical Name Chemical

standard_Browne

ToxCast

ER ER standard_Huang

otal Number of Active Active of Number otal

"ER Model" AUC rank AUC Model" "ER

all active ToxCast active all

"ER Model" AUC score AUC Model" "ER

Lowest AC50 score across across score AC50 Lowest

pathway

(lowest AC (lowest Normalized potency factor factor potency Normalized Moderate- meso-Hexestrol 18 1.0E-05 5.6E-07 strong 0.993 3 1 Strong 17alpha- 16 1.0E-05 6.3E-07 strong Strong 1 2 2 Ethinylestradiol 17alpha-Estradiol 17 1.1E-05 6.3E-07 moderate Moderate 1.06 1 3 Equilin 15 1.0E-05 6.8E-07 NA NA 0.822 6 4 17beta-Estradiol 17 3.1E-05 1.8E-06 strong Strong 0.935 5 5 Raloxifene Antagonist- 14 3.2E-05 2.3E-06 NA 0.0243 188 6 hydrochloride Moderate Diethylstilbestrol 18 7.4E-05 4.1E-06 strong Strong 0.943 4 7 Sodium 2,5-dimethyl- 2 1.1E-05 5.5E-06 NA NA 0.00016 425 8 benzenesulfonate Antagonist 4-Hydroxytamoxifen 13 9.7E-05 7.5E-06 NA 0.0118 260 9 Moderate Zearalenone 17 1.5E-04 8.8E-06 NA NA 0.71 10 10 Table notes: Top ten chemicals are ranked according the normalized potency factor used in the pathway-free method. “ER Model” AUC ranks are based upon position when ranked by AUC score value. CASRN numbers for the top ten chemicals ranked by normalized potency factor are meso-Hexestrol (CASRN: 84-16-2), 17alpha-Ethinylestradiol (CASRN: 57-63-6), 17alpha-Estradiol (CASRN: 57-91-0), Equilin (CASRN: 474-86-2), 17beta-Estradiol (CASRN: 50-28-2), Raloxifene hydrochloride (CASRN: 82640-04- 8), Diethylstilbestrol (CASRN: 56-53-1), Sodium 2,5-dimethylbenzenesulfonate (CASRN: 827-19-0), 4-Hydroxytamoxifen (CASRN: 68392-35-8), Zearalenone (CASRN: 17924-92-4). Total number of ToxCast™ ER assays are out of a possible 18 assays. AC50 and normalized potency are in µM. See footnote 27 for sources of ER standards.

Second, the pathway-free method was superior to the “ER Model” in ranking chemicals with ER antagonist behavior. Using references for agonist and antagonist behavior,32 the pathway-free approach prioritized chemicals with both agonist and antagonist behavior highly in the ranked list (see Table 1). The “ER Model” only prioritized agonist behavior and it is unclear whether the agency will address antagonist behavior at all.

Finally, using p,p'-DDE (CASRN: 72-55-9) as a “cut off” of activity determined by Browne, et al33, 58 out of 521 (11 %) registered pesticides34 would be prioritized for Tier 1 screening using the pathway-free

32 ibid 33 p,p'-DDE was the in vitro standard with the lowest, non-zero AUC score.

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approach compared to only 16 out of 521 (3%) using the “ER Model” ranking (see Table 2 in appendix for detailed chemical ranking). This is an important finding due to the agency’s position that “chemicals would only be queued for T1S [tier 1 screening] assays that are indicated based on the biological activity identified by HTP [high-throughput] assays”.35 Many of the 58 pesticides identified for prioritization by the pathway-free ranking method would fall below an “ER Model” score of 0.136, potentially preventing them from entering the Tier 1 screening queue.

While the precise reasons for why the different approaches result in a different numbers of priority pesticides remains to be determined, the pathway-free method could be capturing a larger number of chemicals due to (1) the inclusion of antagonistic behavior and (2) the inclusion of pathways outside of those considered in the “ER Model” (e.g., non-genomic mechanisms, steroidogenesis). The ability of the pathway-free methods to prioritize a larger number of pesticides, however, indicate that methods that do not rely solely on a pre-determined pathway have the potential to more closely follow EDSTAC recommendations for more inclusive priority setting (see dark grey line in Figure 1).37

While we readily acknowledge that a more quantitative analysis of the sensitivity of a pathway-free approach would be required before recommending its adoption, the simplicity of ranking using a pathway-free approach allows for the rapid creation of a prioritized list, without the added uncertainty, lack of transparency, and complexity associated with a pathway-based model. A rapid ranking and prioritization of chemicals for Tier 1 and Tier 2 screening, with appropriate thresholds that are sufficiently protective against false negatives, could help EDSP orient its focus and allocation of resources toward the chemicals that are of the highest public health importance, without screening out potentially important EDCs.

Moreover, priority lists should not be seen as static entities. The ever-increasing sophistication and detection abilities of high-throughput assays allows for the periodic (no less than every 2-3 years) re- evaluation of each chemical (including those that have not shown endocrine activity in prioritization, Tier 1, or Tier 2 tests) via ToxCast™ or a similar platform.38 Additionally, the agency should develop guidelines for how chemicals that currently reside outside of ToxCast™ testing capability (e.g., chemicals that are insoluble in DMSO, have fluorescent properties, or high volatility) will be evaluated and prioritized for further testing. The ToxCast™ library only includes a small subset of the larger 10,000 chemical EDSP universe, and the agency must not allow technological limitations to prohibit the identification and prioritization of all the potential EDCs in commerce.

In addition to prioritization, data generated using high-throughput mechanistically-based data could be used as an additional stream of information in the evidence integration (weight-of evidence evaluation)

34 The use of pesticides as an example does not imply that non-pesticide chemicals in the EDSP universe should not be ranked and evaluated. It merely serves as an illustration of the potential for a pathway-free approach to be more inclusive than a pathway-based one. 35 U.S. Environmental Protection Agency (2011) EDSP21 Work Plan 36 Meaning that they would be considered inactive. 37 See footnote 4. 38 Such as Tox21.

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process. For example, in its evaluation the carcinogenic potential of an agent, the International Agency for Research on Cancer uses positive results in mechanistic assays to strengthen causal links between exposures and cancer outcomes. Negative results in mechanistic assays, however, provide less weight in the overall hazard determination due to their inability to rule out toxicity via unmeasured alternative mechanisms.39 Though not required for its hazard assessments, the NIEHS National Toxicology Program’s Office of Health Assessment and Translation uses mechanistic data (such as that produced by the ToxCast™ platform) to support the biological plausibility of a chemical agent leading to an adverse effect.40 Mechanistic data can be combined with existing animal and human data to upgrade hazard identification, and could be used in the absence of in vivo data to categorize a chemical as “suspected” of a particular hazard.

Conclusion

In summary, NRDC does not support the replacement of the EDSP Tier 1 uterotrophic, ER binding, or ERTA assays with the proposed “ER Model”. The inability of the model to measure and account for metabolic activity, the reliance of the model on an overly constrained pathway-based model design, the unclear and unlikely model structure/performance, the critically high false negative rate of the model, the lack of confidence in model performance for low and moderate estrogenic chemicals, and the lack of clarity on endpoint behavior to be assessed (i.e., agonist versus antagonist), render it unsuitable for the replacement of Tier 1 tests.

We do, however, recognize the potential for these data streams to aide in the identification of chemical hazards, and encourage the agency to continue its efforts to develop, evolve, and validate these methods for their use in prioritization and evidence integration. Data from high-throughput tools like ToxCast™ and Tox21 can help the agency move chemicals to the top of the priority list, and speed up Tier 1 and Tier 2 evaluations for potentially strong EDCs. Unless and until EPA reorients itself toward identifying high priority chemicals and moving them quickly to a full evaluation and regulatory action, EDSP will remain unresponsive to its statutory mandate.

Thank you for the opportunity to provide comments on this topic.

Sincerely,

Kristi Pullen, Ph.D. Staff Scientist Natural Resources Defense Council

39 International Agency for Research on Cancer (2006) Preamble to the IARC Monographs. 40 National Toxicology Program (2015) Handbook for Conducting a Literature-Based Health Assessment Using OHAT Approach for Systematic Review and Evidence Integration; pp. 66-67

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Table 2. Comparison of pathway-free and pathway-based (“ER Model”) approaches to chemical prioritization – expanded list.

”

/total number number /total

potency factor potency

score across all all across score

“

CASRN

free (normalized (normalized free

active assays) active

potency) rank potency)

Chemical Name Chemical

ToxCast ERassays ToxCast

ERstandard_Huang

Registered Pesticide Registered

"ER Model" AUC rank AUC Model" "ER

"ER Model" AUC score AUC Model" "ER

Total Number of Active Active of Number Total

active ToxCast ER assays ER ToxCast active

pathway

(lowest AC (lowest

Lowest AC Lowest

Normalized Normalized ER agonist standard_Browne ERagonist

84-16-2 meso-Hexestrol 18 1.0E-05 5.6E-07 strong Moderate- 0.993 3 1 no Strong 57-63-6 17alpha-Ethinylestradiol 16 1.0E-05 6.3E-07 strong Strong 1 2 2 no 57-91-0 17alpha-Estradiol 17 1.1E-05 6.3E-07 moderate Moderate 1.06 1 3 no 474-86-2 Equilin 15 1.0E-05 6.8E-07 NA NA 0.822 6 4 no 50-28-2 17beta-Estradiol 17 3.1E-05 1.8E-06 strong Strong 0.935 5 5 no 82640-04-8 Raloxifene hydrochloride 14 3.2E-05 2.3E-06 NA Antagonist- 0.0243 188 6 no Moderate 56-53-1 Diethylstilbestrol 18 7.4E-05 4.1E-06 strong Strong 0.943 4 7 no 827-19-0 Sodium 2,5- 2 1.1E-05 5.5E-06 NA NA 0.00016 425 8 no dimethylbenzenesulfonate 68392-35-8 4-Hydroxytamoxifen 13 9.7E-05 7.5E-06 NA Antagonist 0.0118 260 9 no Moderate 17924-92-4 Zearalenone 17 1.5E-04 8.8E-06 NA NA 0.71 10 10 no 72-33-3 Mestranol 15 2.0E-04 1.3E-05 NA NA 0.742 9 11 no 53-16-7 Estrone 16 2.8E-04 1.7E-05 moderate Moderate 0.807 7 12 no 83-79-4 Rotenone 3 9.8E-05 3.3E-05 NA NA 0.00041 412 13 yes 50-27-1 Estriol 16 6.4E-04 4.0E-05 NA NA 0.786 8 14 no 58-18-4 17-Methyltestosterone 11 9.0E-04 8.2E-05 very_weak Weak 0.495 15 15 no 196808-45-4 Farglitazar 2 1.8E-04 9.2E-05 NA NA 0 NA 16 no 57-85-2 Testosterone propionate 8 9.0E-04 1.1E-04 NA NA 0.392 28 17 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 2971-36-0 2,2-Bis(4-hydroxyphenyl)-1,1,1- 17 3.0E-03 1.8E-04 NA NA 0.568 11 18 trichloroethane no 65277-42-1 Ketoconazole 6 1.4E-03 2.4E-04 inactive NA 0 NA 19 no 50-41-9 Clomiphene citrate 13 3.3E-03 2.6E-04 NA Antagonist- 0.0293 167 20 Moderate no 63-05-8 4-Androstene-3,17-dione 4 1.1E-03 2.8E-04 NA NA 0.183 60 21 no 129453-61-8 Fulvestrant 14 5.7E-03 4.1E-04 NA Antagonist- 0 NA 22 Moderate no 76-87-9 Triphenyltin hydroxide 4 2.0E-03 5.0E-04 NA NA 0 NA 23 yes 68-22-4 Norethindrone 16 9.3E-03 5.8E-04 NA Moderate 0.524 14 24 no 78587-05-0 Hexythiazox 4 2.6E-03 6.6E-04 NA NA 0 NA 25 yes 500-38-9 Nordihydroguaiaretic acid 17 1.3E-02 7.4E-04 NA NA 0.0998 93 26 no 630-56-8 Hydroxyprogesterone caproate 6 5.1E-03 8.5E-04 NA NA 0.0177 220 27 no 446-72-0 Genistein 17 1.5E-02 8.5E-04 weak Weak 0.538 13 28 no 2919-66-6 Melengestrol acetate 3 2.8E-03 9.2E-04 NA NA 0.155 69 29 no 96489-71-3 Pyridaben 5 4.6E-03 9.3E-04 NA NA 0.1 92 30 yes 84371-65-3 Mifepristone 13 1.3E-02 9.8E-04 NA NA 0.00255 376 31 no 101-81-5 Diphenylmethane 6 6.4E-03 1.1E-03 NA NA 0.0207 200 32 no 10161-33-8 17beta-Trenbolone 15 1.7E-02 1.1E-03 NA NA 0.475 17 33 no 111812-58-9 Fenpyroximate (Z,E) 4 4.6E-03 1.2E-03 NA NA 0 NA 34 no 147-81-9 Arabinose 1 1.2E-03 1.2E-03 NA NA 0 NA 35 no 1076-97-7 1,4-Cyclohexanedicarboxylic acid 1 1.2E-03 1.2E-03 NA NA 0 NA 36 no 54965-24-1 Tamoxifen citrate 14 1.7E-02 1.2E-03 NA NA 0.027 179 37 no 199584-38-8 1-Methoxy-4-tert- 2 2.7E-03 1.4E-03 NA NA 0 NA 38 pentylcyclohexane no 1478-61-1 Bisphenol AF 17 2.6E-02 1.5E-03 NA Weak 0.552 12 39 no 64359-81-5 4,5-Dichloro-2-octyl-3(2H)- 7 1.3E-02 1.8E-03 NA NA 0.00534 329 40 isothiazolone yes 58-72-0 Triphenylethylene 15 2.7E-02 1.8E-03 NA NA 0.383 30 41 no 612-82-8 3,3'-Dimethylbenzidine 7 1.3E-02 1.8E-03 NA NA 0.143 74 42 dihydrochloride no 125116-23-6 Metconazole 9 1.9E-02 2.1E-03 NA NA 0.0105 271 43 no 10540-29-1 Tamoxifen 15 3.5E-02 2.3E-03 NA Antagonist 0.0199 206 44 no 13

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 683-18-1 Dibutyltin dichloride 7 1.7E-02 2.5E-03 NA NA 0.00019 422 45 no 81741-28-8 Tributyltetradecylphosphonium 9 2.2E-02 2.5E-03 NA NA 0.093 98 46 chloride no 80-05-7 Bisphenol A 17 5.0E-02 2.9E-03 weak Weak 0.45 18 47 no 6485-40-1 R-(-)-Carvone 3 9.1E-03 3.0E-03 NA NA 0.00195 390 48 no 134-31-6 8-Hydroxyquinoline sulfate 4 1.2E-02 3.1E-03 NA NA 0.00897 285 49 no 131-55-5 2,2',4,4'- 16 5.3E-02 3.3E-03 NA Moderate 0.397 24 50 Tetrahydroxybenzophenone no 1189-08-8 1,3-Butyleneglycol dimethacrylate 1 3.7E-03 3.7E-03 NA NA 0 NA 51 no 3383-96-8 Temephos 5 2.0E-02 3.9E-03 NA NA 0.00268 371 52 yes 1062243-51-9 PharmaGSID_48511 3 1.2E-02 4.1E-03 NA NA NA NA 53 no 4342-36-3 Tributyltin benzoate 8 3.4E-02 4.2E-03 NA NA 0 NA 54 yes 21245-02-3 2-Ethylhexyl 4- 4 1.7E-02 4.2E-03 NA NA 0.0114 266 55 (dimethylamino)benzoate no 486-66-8 Daidzein 16 6.8E-02 4.2E-03 weak Very Weak 0.44 19 56 no NOCAS_34742 Milbemectin (mixture of 70% 4 1.7E-02 4.3E-03 NA NA NA NA 57 Milbemcin A4, 30% Milbemycin A3) no 521-18-6 5alpha-Dihydrotestosterone 14 6.3E-02 4.5E-03 weak NA 0.4 23 58 no 114369-43-6 Fenbuconazole 3 1.5E-02 4.9E-03 NA NA 0.00054 407 59 yes 104-43-8 4-Dodecylphenol 17 8.4E-02 5.0E-03 NA NA 0.41 22 60 no 1007-28-9 Deisopropylatrazine 2 1.0E-02 5.0E-03 NA NA 0.00394 349 61 no 77-40-7 Bisphenol B 16 8.5E-02 5.3E-03 weak Weak 0.491 16 62 no 131-57-7 2-Hydroxy-4- 8 4.3E-02 5.4E-03 NA NA 0.0645 121 63 methoxybenzophenone no 1067-53-4 Tris(2-methoxyethoxy)vinylsilane 2 1.1E-02 5.5E-03 NA NA 0 NA 64 no 55285-14-8 Carbosulfan 5 2.8E-02 5.5E-03 NA NA 0.0115 264 65 no 520-36-5 Apigenin 13 7.4E-02 5.7E-03 very_weak NA 0.307 37 66 no 27955-94-8 4,4',4'-Ethane-1,1,1-triyltriphenol 16 9.4E-02 5.9E-03 NA NA 0.319 36 67 no 119168-77-3 Tebufenpyrad 3 1.8E-02 5.9E-03 NA NA 0 NA 68 no 1085-12-7 Heptylparaben 17 1.0E-01 5.9E-03 NA NA 0.269 41 69 no 90357-06-5 Bicalutamide 6 3.8E-02 6.4E-03 NA NA 0.00307 366 70 no 2795-39-3 PFOS-K 4 2.7E-02 6.6E-03 NA NA 0 NA 71 no 695-06-7 gamma-Caprolactone 2 1.5E-02 7.4E-03 NA NA 0 NA 72 no 14

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 129-17-9 Sulfan blue 2 1.5E-02 7.6E-03 NA NA 0 NA 73 no 427-51-0 Cyproterone acetate 2 1.6E-02 7.8E-03 NA NA 0.00054 408 74 no 789-02-6 o,p'-DDT 13 1.1E-01 8.1E-03 weak Weak; 0.385 29 75 Negative- Weak Agonist no 60-51-5 Dimethoate 2 1.7E-02 8.7E-03 NA NA 0 NA 76 yes 57-83-0 Progesterone 8 7.0E-02 8.8E-03 NA Negative 0.0507 133 77 no 84852-15-3 4-Nonylphenol, branched 16 1.4E-01 8.9E-03 NA Weak 0.435 20 78 no 41372-20-7 Apomorphine hydrochloride hydrate 4 3.7E-02 9.4E-03 NA NA 0.00617 316 79 no 143390-89-0 Kresoxim-methyl 14 1.3E-01 9.5E-03 NA NA 0.0154 236 80 yes 59669-26-0 Thiodicarb 2 1.9E-02 9.5E-03 NA NA 0 NA 81 yes 599-64-4 4-Cumylphenol 16 1.7E-01 1.0E-02 weak Weak 0.376 31 82 no 50-22-6 Corticosterone 2 2.1E-02 1.1E-02 inactive Negative 0.000056 462 83 no 105624-86-0 5HPP-33 15 1.7E-01 1.1E-02 NA NA 0.418 21 84 no 110-87-2 3,4-Dihydro-2H-pyran 1 1.2E-02 1.2E-02 NA NA 0 NA 85 no 17696-62-7 Phenylparaben 15 1.7E-01 1.2E-02 NA NA 0.275 40 86 no 18924-66-8 2,2'-(Tetradecylimino)diethanol 7 8.3E-02 1.2E-02 NA NA 0 NA 87 no 929-59-9 2,2'-[Ethane-1,2- 2 2.5E-02 1.2E-02 NA NA NA NA 88 diylbis(oxy)]diethanamine no 989-38-8 Rhodamine 6G 6 7.5E-02 1.2E-02 NA NA NA NA 89 no 13680-35-8 4,4'-Methylenebis(2,6- 5 6.3E-02 1.3E-02 NA NA 0.000011 475 90 diethylaniline) no 22839-47-0 Aspartame 3 3.8E-02 1.3E-02 NA NA 0.00559 325 91 no 53-43-0 Dehydroepiandrosterone 16 2.0E-01 1.3E-02 NA NA 0.365 33 92 no 50-65-7 Niclosamide 2 2.6E-02 1.3E-02 NA NA 0 NA 93 no 67485-29-4 Hydramethylnon 8 1.1E-01 1.3E-02 NA NA 0.2 57 94 yes 94-18-8 Benzylparaben 15 2.1E-01 1.4E-02 NA NA 0.234 52 95 no 2934-05-6 2,4-Diisopropylphenol 4 5.7E-02 1.4E-02 NA NA 0.00488 336 96 no 33820-53-0 Isopropalin 8 1.2E-01 1.5E-02 NA NA 0.0122 255 97 yes 106-48-9 4-Chlorophenol 8 1.2E-01 1.5E-02 NA NA 0.0293 168 98 no 69806-50-4 Fluazifop-butyl 1 1.5E-02 1.5E-02 NA NA 0 NA 99 yes

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 18979-55-0 4-(Hexyloxy)phenol 11 1.7E-01 1.5E-02 NA NA 0.161 67 100 no 1031-07-8 Endosulfan sulfate 4 6.1E-02 1.5E-02 NA NA 0 NA 101 no NOCAS_48505 PharmaGSID_48505 4 6.3E-02 1.6E-02 NA NA NA NA 102 no 27193-86-8 Dodecylphenol 16 2.7E-01 1.7E-02 NA NA 0.392 27 103 no 520-18-3 Kaempferol 12 2.0E-01 1.7E-02 very_weak NA 0.252 46 104 no 150-76-5 4-Methoxyphenol 1 1.7E-02 1.7E-02 NA NA 0 NA 105 no 140-66-9 4-(1,1,3,3-Tetramethylbutyl)phenol 18 3.2E-01 1.8E-02 moderate Weak 0.393 26 106 no 2390-60-5 Basic Blue 7 5 8.8E-02 1.8E-02 NA NA 0 NA 107 no 33228-45-4 4-Hexylaniline 8 1.5E-01 1.8E-02 NA NA 0.00955 276 108 no 181274-15-7 Propoxycarbazone-sodium 1 1.9E-02 1.9E-02 NA NA 0 NA 109 no 99-08-1 3-Nitrotoluene 2 3.7E-02 1.9E-02 NA NA NA NA 110 no 1008-72-6 Sodium 2-formylbenzenesulfonate 1 1.9E-02 1.9E-02 NA NA 0 NA 111 no 77-09-8 Phenolphthalein 16 3.3E-01 2.0E-02 NA Moderate 0.276 39 112 no 101-05-3 Anilazine 1 2.1E-02 2.1E-02 NA NA 0.000043 470 113 yes 2392-39-4 Dexamethasone sodium phosphate 1 2.1E-02 2.1E-02 NA NA 0 NA 114 no 98730-04-2 Benoxacor 3 6.3E-02 2.1E-02 NA NA 0.00036 414 115 no 797-63-7 Norgestrel 9 1.9E-01 2.1E-02 NA NA 0.394 25 116 no 56-95-1 Chlorhexidine diacetate 7 1.5E-01 2.1E-02 NA NA 0.00201 388 117 yes 50-14-6 Ergocalciferol 2 4.4E-02 2.2E-02 NA NA 0 NA 118 no 501027-49-2 PD-0333941 2 4.5E-02 2.2E-02 NA NA 0 NA 119 no 5153-25-3 2-Ethylhexylparaben 17 3.8E-01 2.2E-02 NA NA 0.37 32 120 no 444610-91-7 PharmaGSID_47315 2 4.8E-02 2.4E-02 NA NA 0 NA 121 no 120511-73-1 Anastrozole 4 1.0E-01 2.5E-02 NA NA 0.0201 205 122 no 17372-87-1 Eosin 4 1.0E-01 2.5E-02 NA NA 0 NA 123 no 491-80-5 Biochanin A 16 4.2E-01 2.6E-02 NA NA 0.356 34 124 no 684-93-5 N-Nitroso-N-methylurea 3 8.2E-02 2.7E-02 NA NA 0.00097 404 125 no 77-47-4 Hexachlorocyclopentadiene 4 1.1E-01 2.8E-02 NA NA 0.00973 274 126 yes 143-50-0 Kepone 11 3.1E-01 2.8E-02 weak Weak 0.174 64 127 no 63449-41-2 C8-18-Alkydimethylbenzyl 10 2.9E-01 2.9E-02 NA NA 0.0312 163 128 ammonium chlorides yes 1582-09-8 Trifluralin 3 9.5E-02 3.2E-02 NA NA 0.0337 160 129 yes 5349-51-9 4-(2-Methylbutan-2-yl)cyclohexanol 9 3.1E-01 3.4E-02 NA NA 0.248 49 130 no 16

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 NOCAS_47353 SSR241586 6 2.1E-01 3.5E-02 NA NA NA NA 131 no 180084-01-9 SB236057A 5 1.8E-01 3.6E-02 NA NA 0 NA 132 no NOCAS_48176 YM218 1 3.7E-02 3.7E-02 NA NA NA NA 133 no 68-96-2 17alpha-Hydroxyprogesterone 4 1.6E-01 3.9E-02 NA NA 0.343 35 134 no 4130-42-1 2,6-Di-tert-butyl-4-ethylphenol 2 8.2E-02 4.1E-02 NA NA 0 NA 135 no 111-20-6 Decanedioic acid 1 4.2E-02 4.2E-02 NA NA NA NA 136 no 621-64-7 N-Nitrosodipropylamine 2 8.5E-02 4.2E-02 NA NA 0 NA 137 no 1559-35-9 2-(2-Ethylhexyloxy)ethanol 3 1.3E-01 4.3E-02 NA NA 0.00053 409 138 no 644-97-3 Phenyl phosphorus dichloride 2 8.8E-02 4.4E-02 NA NA 0 NA 139 no 20325-40-0 3,3'-Dimethoxybenzidine 3 1.4E-01 4.6E-02 NA NA 0 NA 140 dihydrochloride no 2231-57-4 Thiocarbazide 2 9.3E-02 4.7E-02 NA NA 0 NA 141 no 80-46-6 4-(2-Methylbutan-2-yl)phenol 13 6.3E-01 4.9E-02 NA NA 0.282 38 142 yes 1675-54-3 Bisphenol A diglycidyl ether 2 1.0E-01 5.1E-02 NA NA 0 NA 143 no 80-09-1 4,4'-Sulfonyldiphenol 15 8.0E-01 5.3E-02 NA NA 0.263 44 144 no 70-55-3 4-Toluenesulfonamide 1 5.3E-02 5.3E-02 NA NA 0 NA 145 no 97322-87-7 Troglitazone 4 2.3E-01 5.7E-02 NA NA 0.000063 455 146 no 80-43-3 Dicumyl peroxide 12 6.8E-01 5.7E-02 NA NA 0.216 55 147 no 108-68-9 3,5-Dimethylphenol 1 5.7E-02 5.7E-02 NA NA 0 NA 148 no 27306-78-1 Silwet L77 8 4.6E-01 5.7E-02 NA NA 0.00023 419 149 no 53-19-0 o,p'-DDD 16 9.6E-01 6.0E-02 NA NA 0.236 51 150 no 26027-38-3 Polyoxyethylene(10)nonylphenyl 9 5.5E-01 6.1E-02 NA NA 0.0406 147 151 ether no 6683-19-8 Irganox 1010 5 3.2E-01 6.3E-02 NA NA 0.149 71 152 no 79-24-3 Nitroethane 1 6.3E-02 6.3E-02 NA NA 0 NA 153 no 92-68-2 4-Cyclohexylcyclohexanone 3 1.9E-01 6.4E-02 NA NA 0.0491 135 154 no 105-55-5 N,N'-Diethylthiourea 2 1.3E-01 6.5E-02 NA NA 0.0196 208 155 no 72-43-5 Methoxychlor 14 9.1E-01 6.5E-02 very_weak (Metabolism 0.254 45 156 Required) yes 94-26-8 Butylparaben 15 9.9E-01 6.6E-02 NA Weak 0.251 47 157 yes 112226-61-6 Halofenozide 1 6.6E-02 6.6E-02 NA NA 0 NA 158 yes 203942-49-8 UK-337312 4 2.7E-01 6.8E-02 NA NA 0.0021 385 159 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 4574-04-3 Myristyltrimethylammonium 6 4.1E-01 6.8E-02 NA NA 0.0071 310 160 chlorideN,N,N-Trimethyltetradecan- 1-aminium chloride no 2396-68-1 4-tert-Butylbenzenethiol 4 2.8E-01 6.9E-02 NA NA 0.0234 191 161 no 6088-51-3 6-Hydroxy-2-naphthyl disulfide 17 1.2E+00 6.9E-02 NA NA 0.25 48 162 no 57-11-4 Octadecanoic acid 6 4.2E-01 6.9E-02 NA NA 0.248 50 163 yes 107-30-2 Chloromethyl methyl ether 3 2.1E-01 7.0E-02 NA NA 0.0306 164 164 no 2155-70-6 Tributyltin methacrylate 5 3.5E-01 7.0E-02 NA NA 0 NA 165 yes 563-12-2 Ethion 11 7.8E-01 7.1E-02 NA NA 0.0974 95 166 yes 131-56-6 2,4-Dihydroxybenzophenone 16 1.2E+00 7.3E-02 NA NA 0.266 43 167 no 78-42-2 Tris(2-ethylhexyl) phosphate 2 1.5E-01 7.5E-02 NA NA 0.00568 324 168 no 548-62-9 Gentian Violet 4 3.0E-01 7.5E-02 NA NA 0 NA 169 yes 90-72-2 2,4,6- 1 7.7E-02 7.7E-02 NA NA 0 NA 170 Tris(dimethylaminomethyl)phenol no 119446-68-3 Difenoconazole 3 2.3E-01 7.7E-02 NA NA 0 NA 171 yes 69806-40-2 Haloxyfop-methyl 2 1.6E-01 8.1E-02 NA NA 0 NA 172 no 69-09-0 Chlorpromazine hydrochloride 3 2.4E-01 8.1E-02 NA NA 0 NA 173 no 22260-51-1 Bromocriptine mesylate 2 1.6E-01 8.2E-02 NA NA 0 NA 174 no 5137-55-3 Methyltrioctylammonium chloride 4 3.4E-01 8.4E-02 NA NA 0.00331 360 175 no 1120-36-1 1-Tetradecene 1 8.5E-02 8.5E-02 NA NA NA NA 176 no 3811-73-2 Sodium (2-pyridylthio)-N-oxide 5 4.3E-01 8.6E-02 NA NA 0 NA 177 yes 1461-22-9 Tributyltin chloride 5 4.4E-01 8.7E-02 NA NA 0 NA 178 yes 66-81-9 Cycloheximide 4 3.6E-01 8.9E-02 inactive NA 0 NA 179 yes 72-20-8 Endrin 3 2.7E-01 9.1E-02 NA NA 0 NA 180 yes 126-92-1 Sodium ethasulfate 1 9.4E-02 9.4E-02 NA NA 0 NA 181 no 140-64-7 Pentamidine isethionate 6 5.9E-01 9.8E-02 NA NA 0 NA 182 no 23593-75-1 Clotrimazole 5 4.9E-01 9.8E-02 NA NA 0.00043 411 183 no 686756-87-6 PharmaGSID_48519 4 4.0E-01 9.9E-02 NA NA NA NA 184 no 51-24-1 Tiratricol 10 1.0E+00 1.0E-01 NA NA 0.179 62 185 no 83-88-5 Riboflavin 3 3.0E-01 1.0E-01 NA NA 0 NA 186 no 79-95-8 2,2',6,6'-Tetrachlorobisphenol A 15 1.5E+00 1.0E-01 NA NA 0.19 58 187 no 102409-92-7 FR073317 3 3.1E-01 1.0E-01 NA NA NA NA 188 no 18

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 1219-38-1 Octylparaben 17 1.8E+00 1.0E-01 NA NA 0.268 42 189 no 5146-66-7 2,6-Octadienenitrile, 3,7-dimethyl- 2 2.1E-01 1.0E-01 NA NA 0 NA 190 no 97-56-3 2-Amino-5-azotoluene 11 1.2E+00 1.1E-01 NA NA 0.142 76 191 no 92-69-3 4-Phenylphenol 15 1.6E+00 1.1E-01 NA NA 0.219 54 192 no 108-95-2 Phenol 1 1.1E-01 1.1E-01 NA NA NA NA 193 yes 654055-01-3 Morin hydrate 5 5.6E-01 1.1E-01 NA NA 0.0898 100 194 no 1987-50-4 4-Heptylphenol 10 1.1E+00 1.1E-01 NA Weak 0.113 86 195 no 302-79-4 trans-Retinoic acid 2 2.3E-01 1.2E-01 NA NA 0.00023 420 196 no 50-21-5 Lactic acid 1 1.2E-01 1.2E-01 NA NA 0 NA 197 no 51-52-5 6-Propyl-2-thiouracil 5 6.3E-01 1.3E-01 NA NA 0.144 73 198 no 96-83-3 Iopanoic acid 11 1.4E+00 1.3E-01 NA NA 0.0454 140 199 no 98-54-4 4-tert-Butylphenol 12 1.6E+00 1.4E-01 NA NA 0.161 66 200 yes 126-06-7 3-Bromo-1-chloro-5,5- 1 1.4E-01 1.4E-01 NA NA 0 NA 201 dimethylhydantoin yes 125225-28-7 Ipconazole 4 5.6E-01 1.4E-01 NA NA 0 NA 202 no 117-79-3 2-Aminoanthraquinone 3 4.3E-01 1.4E-01 NA NA 0.0453 141 203 no 53-70-3 Dibenz(a,h)anthracene 1 1.5E-01 1.5E-01 NA NA 0 NA 204 no 29091-21-2 Prodiamine 9 1.4E+00 1.6E-01 NA NA 0.00775 299 205 yes 24169-02-6 Econazole nitrate 5 8.2E-01 1.6E-01 NA NA 0 NA 206 no 120-32-1 Clorophene 11 1.8E+00 1.7E-01 NA NA 0.0353 157 207 yes 86-73-7 Fluorene 3 5.1E-01 1.7E-01 NA NA 0 NA 208 no 92-04-6 2-Chloro-4-phenylphenol 9 1.5E+00 1.7E-01 NA NA 0.138 79 209 no 9004-82-4 Sodium lauryl polyoxyethylene ether 8 1.4E+00 1.7E-01 NA NA 0.00534 328 210 sulfate yes 102676-31-3 Fadrozole hydrochloride 6 1.0E+00 1.7E-01 NA NA 0.0825 109 211 no 62924-70-3 Flumetralin 10 1.8E+00 1.8E-01 NA NA 0.224 53 212 yes 375-95-1 PFNA 4 7.1E-01 1.8E-01 NA NA 0.00751 301 213 no 31519-22-9 1,4-Dihydroxy-2-naphthoic acid 3 5.3E-01 1.8E-01 NA NA 0 NA 214 no 249296-43-3 CJ-013610 6 1.1E+00 1.9E-01 NA NA 0.000044 467 215 no 13463-41-7 Zinc pyrithione 8 1.5E+00 1.9E-01 NA NA 0 NA 216 yes 4151-50-2 Sulfluramid 3 5.7E-01 1.9E-01 NA NA 0 NA 217 yes 136-77-6 4-Hexylresorcinol 11 2.2E+00 2.0E-01 NA NA 0.0687 114 218 no 19

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 120-56-9 Triethylene glycol dibenzoate 3 6.0E-01 2.0E-01 NA NA 0.0732 112 219 no 62-38-4 Phenylmercuric acetate 5 1.1E+00 2.1E-01 NA NA 0 NA 220 yes 319-85-7 beta-Hexachlorocyclohexane 4 8.6E-01 2.2E-01 NA NA 0.082 111 221 no 104-40-5 4-Nonylphenol 10 2.2E+00 2.2E-01 very_weak Weak 0.088 101 222 no 66575-29-9 Forskolin 4 8.7E-01 2.2E-01 NA NA 0.0528 130 223 no 1461-25-2 Tetrabutyltin 4 8.9E-01 2.2E-01 NA NA 0 NA 224 no 480-40-0 Chrysin 8 1.8E+00 2.2E-01 very_weak NA 0.134 82 225 no 1806-26-4 4-Octylphenol 10 2.2E+00 2.2E-01 NA NA 0.118 83 226 no 139-96-8 Dodecyl sulfate triethanolamine 2 4.5E-01 2.3E-01 NA NA 0.000072 450 227 yes 7173-51-5 Didecyldimethylammonium chloride 6 1.4E+00 2.3E-01 NA NA 0.00313 365 228 yes 14816-18-3 Phoxim 12 2.8E+00 2.3E-01 NA NA 0.156 68 229 no 175013-18-0 Pyraclostrobin 3 7.2E-01 2.4E-01 NA NA 0 NA 230 yes 262376-75-0 HMR1426 3 7.3E-01 2.4E-01 NA NA 0.0176 222 231 no 127308-82-1 Zamifenacin 6 1.5E+00 2.5E-01 NA NA 0.0271 178 232 no 60-57-1 Dieldrin 4 1.0E+00 2.5E-01 NA NA 0.0181 219 233 yes 155990-20-8 SR271425 5 1.3E+00 2.5E-01 NA NA 0.0558 129 234 no 41481-66-7 4,4'-Sulfonylbis[2-(prop-2-en-1- 7 1.8E+00 2.5E-01 NA NA 0.0231 193 235 yl)phenol] no 611-70-1 Isopropyl phenyl ketone 2 5.1E-01 2.6E-01 NA NA 0.00034 416 236 no 16587-71-6 4-(tert-Pentyl)-cyclohexanone 4 1.0E+00 2.6E-01 NA NA 0.0437 143 237 no 95-74-9 3-Chloro-4-methylaniline 3 7.9E-01 2.6E-01 NA NA 0.00428 345 238 no 115-29-7 Endosulfan 5 1.4E+00 2.7E-01 NA NA 0.0295 166 239 yes 99-71-8 4-(Butan-2-yl)phenol 11 3.0E+00 2.7E-01 NA NA 0.163 65 240 no 1034-01-1 Octyl gallate 12 3.4E+00 2.8E-01 NA NA 0.0144 240 241 no 3691-35-8 Chlorophacinone 5 1.4E+00 2.9E-01 NA NA 0 NA 242 yes 2104-64-5 EPN 11 3.2E+00 2.9E-01 NA NA 0.0868 105 243 yes 50-29-3 p,p'-DDT 11 3.3E+00 3.0E-01 NA NA 0.19 59 244 yes 84-61-7 Dicyclohexyl phthalate 7 2.1E+00 3.0E-01 NA NA 0.0199 207 245 no 959-98-8 Endosulfan I 8 2.5E+00 3.1E-01 NA NA 0.0619 123 246 no 68-11-1 Thioglycolic acid 2 6.2E-01 3.1E-01 NA NA 0 NA 247 no 131341-86-1 Fludioxonil 9 2.8E+00 3.1E-01 NA NA 0.0521 131 248 yes 10016-20-3 alpha-Cyclodextrin 3 9.3E-01 3.1E-01 NA NA 0.00038 413 249 no 20

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 94-13-3 Propylparaben 14 4.4E+00 3.2E-01 NA NA 0.205 56 250 yes 5915-41-3 Terbuthylazine 5 1.6E+00 3.2E-01 NA NA 0.057 127 251 yes 140-10-3 Cinnamic acid 7 2.3E+00 3.2E-01 NA NA 0.101 91 252 no 52-01-7 Spironolactone 2 6.5E-01 3.2E-01 inactive NA 0.00028 417 253 no 402910-27-4 UK-416244 3 9.7E-01 3.2E-01 NA NA 0 NA 254 no 139-13-9 Nitrilotriacetic acid 2 6.5E-01 3.3E-01 NA NA 0.0176 223 255 no 676116-04-4 PD 0343701 6 2.0E+00 3.3E-01 NA NA 0 NA 256 no 725228-45-5 AVE5638 4 1.3E+00 3.3E-01 NA NA 0.00507 332 257 no 2058-94-8 Perfluoroundecanoic acid 4 1.3E+00 3.3E-01 NA NA 0.00337 359 258 no 5598-15-2 Chlorpyrifos oxon 5 1.8E+00 3.5E-01 NA NA 0 NA 259 no 1241-94-7 2-Ethylhexyl diphenyl phosphate 3 1.1E+00 3.6E-01 NA NA 0.0117 262 260 no 108-38-3 1,3-Dimethylbenzene 1 3.6E-01 3.6E-01 NA NA 0 NA 261 no 116255-48-2 Bromuconazole 5 1.8E+00 3.6E-01 NA NA 0 NA 262 yes 6344-67-8 3-Hydroxyfluorene 11 4.1E+00 3.7E-01 NA NA 0.0945 96 263 no 32388-55-9 1-Cedr-8-en-9-ylethanone 7 2.7E+00 3.8E-01 NA NA 0.0562 128 264 no 25155-18-4 Methylbenzethonium chloride 11 4.2E+00 3.8E-01 NA NA 0.00822 293 265 yes 6459-94-5 C.I. Acid Red 114 4 1.6E+00 3.9E-01 NA NA 0 NA 266 no 838-88-0 4,4'-Methylenebis(2-methylaniline) 11 4.5E+00 4.0E-01 NA NA 0.0458 139 267 no 97-23-4 Dichlorophen 8 3.2E+00 4.1E-01 NA NA 0.0058 323 268 yes 960-71-4 Triphenylborane 13 5.3E+00 4.1E-01 NA NA 0.101 89 269 no 61-73-4 Methylene blue 8 3.3E+00 4.1E-01 NA NA 0.00154 397 270 yes 6893-02-3 3,5,3'-Triiodothyronine 6 2.4E+00 4.1E-01 NA NA 0.135 80 271 no 60207-90-1 Propiconazole 4 1.7E+00 4.1E-01 NA NA 0.000044 468 272 yes 126-00-1 Diphenolic acid 15 6.2E+00 4.2E-01 NA NA 0.174 63 273 no 72-55-9 p,p'-DDE 8 3.5E+00 4.4E-01 very_weak NA 0.0677 115 274 no 1638-22-8 4-Butylphenol 11 4.8E+00 4.4E-01 NA NA 0.111 87 275 no NOCAS_47374 SSR161421 3 1.3E+00 4.4E-01 NA NA 0.000006 478 276 no 205-99-2 Benzo(b)fluoranthene 4 1.8E+00 4.6E-01 NA NA 0.012 259 277 no 101-02-0 Triphenyl phosphite 5 2.3E+00 4.6E-01 NA NA 0.0021 384 278 no 126833-17-8 Fenhexamid 13 6.1E+00 4.7E-01 NA NA 0.148 72 279 yes 140-11-4 Benzyl acetate 1 4.7E-01 4.7E-01 NA NA 0 NA 280 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 6846-50-0 2,2,4-Trimethyl-1,3-pentanediol 4 1.9E+00 4.7E-01 NA NA 0.0272 176 281 diisobutyrate no 2554-06-5 1,3,5,7-Tetramethyl-1,3,5,7- 7 3.3E+00 4.7E-01 NA NA 0.0268 180 282 tetravinylcyclotetrasiloxane no 20830-75-5 Digoxin 1 4.8E-01 4.8E-01 NA NA 0 NA 283 no 1836-75-5 Nitrofen 2 9.5E-01 4.8E-01 NA NA 0 NA 284 yes 200940-23-4 SB243213A 2 9.6E-01 4.8E-01 NA NA 0 NA 285 no 60168-88-9 Fenarimol 10 4.9E+00 4.9E-01 very_weak NA 0.105 88 286 yes 107-98-2 1-Methoxy-2-propanol 4 1.9E+00 4.9E-01 NA NA 0.0156 234 287 no 56-55-3 Benz(a)anthracene 4 2.0E+00 4.9E-01 NA (Metabolism 0.0372 155 288 Required) Negative- Weak Agonist no 85-68-7 Butyl benzyl phthalate 13 6.4E+00 4.9E-01 very_weak NA 0.179 61 289 no 78-11-5 Pentaerythritol tetranitrate 4 2.1E+00 5.2E-01 NA NA 0 NA 290 no 171866-31-2 CP-283097 2 1.1E+00 5.3E-01 NA NA 0.0212 198 291 no 112-00-5 Dodecyltrimethylammonium 4 2.1E+00 5.3E-01 NA NA 0.00011 432 292 chloride yes 2772-45-4 2,4-Bis(1-methyl-1- 6 3.2E+00 5.3E-01 NA NA 0.0274 175 293 phenylethyl)phenol no 68694-11-1 Triflumizole 3 1.6E+00 5.3E-01 NA NA 0 NA 294 yes 102-71-6 Triethanolamine 2 1.1E+00 5.5E-01 NA NA 0 NA 295 yes 99-85-4 gamma-Terpinene 1 5.6E-01 5.6E-01 NA NA NA NA 296 no 754-91-6 PFOSA 11 6.1E+00 5.6E-01 NA NA 0.024 189 297 no 23386-52-9 Dicyclohexyl sodium sulfosuccinate 1 5.7E-01 5.7E-01 NA NA 0 NA 298 no 57-74-9 Chlordane 7 4.0E+00 5.7E-01 NA NA 0.0191 210 299 yes 4712-55-4 Diphenyl phosphite 12 6.9E+00 5.8E-01 NA NA 0.142 75 300 no 604-75-1 Oxazepam 2 1.2E+00 5.9E-01 NA NA 0.00109 402 301 no 111-44-4 Bis(2-chloroethyl) ether 1 5.9E-01 5.9E-01 NA NA 0 NA 302 no 842-07-9 C.I. Solvent Yellow 14 4 2.4E+00 5.9E-01 NA NA 0.117 84 303 no 328392-46-7 HMR1171 2 1.2E+00 6.0E-01 NA NA NA NA 304 no 120-47-8 Ethylparaben 11 6.8E+00 6.2E-01 very_weak Very Weak 0.0864 108 305 no 22

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 90-30-2 N-Phenyl-1-naphthylamine 3 1.9E+00 6.2E-01 NA NA 0.0386 153 306 no 27176-87-0 Dodecylbenzenesulfonic acid 6 3.8E+00 6.3E-01 NA NA 0.00049 410 307 yes 58-14-0 Pyrimethamine 2 1.3E+00 6.4E-01 NA NA 0 NA 308 no NOCAS_47364 SSR103800 2 1.3E+00 6.5E-01 NA NA NA NA 309 no 124-22-1 1-Dodecanamine 7 4.5E+00 6.5E-01 NA NA 0.149 70 310 no 117428-22-5 Picoxystrobin 3 2.0E+00 6.5E-01 NA NA 0 NA 311 no 106-43-4 4-Chlorotoluene 1 6.5E-01 6.5E-01 NA NA 0 NA 312 no NOCAS_47381 AVE8923 4 2.7E+00 6.7E-01 NA NA NA NA 313 no 119-61-9 Benzophenone 8 5.4E+00 6.7E-01 NA NA 0.04 150 314 no 88-85-7 Dinoseb 3 2.1E+00 7.0E-01 NA NA 0 NA 315 yes 21145-77-7 6-Acetyl-1,1,2,4,4,7- 6 4.3E+00 7.2E-01 NA NA 0.0388 152 316 hexamethyltetralin no 33228-44-3 4-Pentylaniline 6 4.4E+00 7.3E-01 NA Weak 0.0138 244 317 no 119-93-7 3,3'-Dimethylbenzidine 9 6.6E+00 7.3E-01 NA NA 0.139 78 318 no 106-50-3 1,4-Benzenediamine 7 5.3E+00 7.5E-01 NA NA 0.0201 204 319 no 1072-15-7 Sulfuric acid, monononyl ester, 6 4.5E+00 7.6E-01 NA NA 0.093 99 320 sodium salt no 6055-19-2 Cyclophosphamide monohydrate 4 3.1E+00 7.9E-01 NA NA 0.135 81 321 no 120068-37-3 Fipronil 4 3.1E+00 7.9E-01 NA NA 0 NA 322 yes 78473-71-9 Enterolactone 9 7.2E+00 8.0E-01 NA NA 0.0866 106 323 no 115-86-6 Triphenyl phosphate 8 6.6E+00 8.2E-01 NA NA 0.0641 122 324 no 742693-38-5 SSR504734 3 2.5E+00 8.3E-01 NA NA 0 NA 325 no 288104-79-0 Surinabant 5 4.2E+00 8.3E-01 NA NA 0.0866 107 326 no 39300-45-3 Dinocap 5 4.2E+00 8.3E-01 NA NA 0 NA 327 yes 1120-04-3 Octadecyl sulfate sodium salt 5 4.3E+00 8.6E-01 NA NA 0.00252 377 328 no 121-00-6 2-tert-Butyl-4-methoxyphenol 6 5.2E+00 8.7E-01 NA NA 0.0139 243 329 no 41198-08-7 Profenofos 5 4.3E+00 8.7E-01 NA NA 0.0025 378 330 yes 84-75-3 Dihexyl phthalate 4 3.5E+00 8.8E-01 NA NA 0.0096 275 331 no 8004-92-0 C.I. Acid Yellow 3 disodium salt 1 8.9E-01 8.9E-01 NA NA 0 NA 332 no 87-18-3 4-tert-Butylphenyl salicylate 6 5.5E+00 9.1E-01 NA NA 0.0488 136 333 no 79622-59-6 Fluazinam 5 4.6E+00 9.2E-01 NA NA 0 NA 334 yes 55-98-1 Busulfan 1 9.2E-01 9.2E-01 NA NA 0 NA 335 no 23

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 NOCAS_47328 MK-274 3 2.8E+00 9.3E-01 NA NA NA NA 336 no 141-79-7 4-Methylpent-3-en-2-one 7 6.6E+00 9.4E-01 NA NA 0.14 77 337 no 5315-79-7 1-Hydroxypyrene 4 3.8E+00 9.4E-01 NA NA 0.00941 280 338 no 496-72-0 3,4-Diaminotoluene 2 1.9E+00 9.4E-01 NA NA 0.000054 465 339 no 3319-31-1 Tris(2-ethylhexyl) trimellitate 13 1.2E+01 9.5E-01 NA NA 0.115 85 340 no 135-19-3 2-Naphthalenol 12 1.2E+01 9.6E-01 NA NA 0.0874 104 341 yes 2312-35-8 Propargite 3 2.9E+00 9.7E-01 NA NA 0 NA 342 yes 111-71-7 Heptanal 5 5.0E+00 1.0E+00 NA NA 0.0319 161 343 no 35256-85-0 Butam 8 8.0E+00 1.0E+00 NA NA 0.0822 110 344 no 712-50-5 Cyclohexylphenylketone 6 6.2E+00 1.0E+00 NA Weak 0.0191 211 345 no 57-97-6 7,12-Dimethylbenz(a)anthracene 3 3.1E+00 1.0E+00 NA NA 0.00017 424 346 no 585-34-2 3-tert-Butylphenol 7 7.3E+00 1.0E+00 NA NA 0.0248 187 347 no 2433-14-9 4-Cyclohexylcyclohexanol 7 7.3E+00 1.0E+00 NA NA 0.0253 185 348 no 4291-63-8 Cladribine 3 3.1E+00 1.0E+00 NA NA 0.0207 202 349 no 119-47-1 2,2'-Methylenebis(4-methyl-6-tert- 5 5.4E+00 1.1E+00 NA NA 0.00113 401 350 butylphenol) no 35400-43-2 Sulprofos 4 4.4E+00 1.1E+00 NA NA 0.0115 265 351 yes 510-15-6 Chlorobenzilate 3 3.3E+00 1.1E+00 NA NA 0 NA 352 yes 122453-73-0 Chlorfenapyr 4 4.5E+00 1.1E+00 NA NA 0 NA 353 yes 82385-42-0 Sodium saccharin hydrate 2 2.3E+00 1.2E+00 NA NA 0.0257 184 354 no 534-13-4 N,N'-Dimethylthiourea 3 3.5E+00 1.2E+00 NA NA 0 NA 355 no 298-04-4 Disulfoton 5 5.9E+00 1.2E+00 NA NA 0.025 186 356 yes 77-93-0 Triethyl citrate 1 1.2E+00 1.2E+00 NA NA 0.00006 459 357 no 111-30-8 Glutaraldehyde 2 2.4E+00 1.2E+00 NA NA 0 NA 358 yes 120-46-7 1,3-Diphenyl-1,3-propanedione 6 7.2E+00 1.2E+00 NA NA 0.0491 134 359 no 79-94-7 3,3',5,5'-Tetrabromobisphenol A 4 4.9E+00 1.2E+00 NA NA 0 NA 360 no 51632-16-7 1-(Bromomethyl)-3- 10 1.2E+01 1.2E+00 NA NA 0.0607 124 361 phenoxybenzene no 5333-42-6 2-Octyl-1-dodecanol 2 2.4E+00 1.2E+00 NA NA 0 NA 362 no 117-39-5 Quercetin 9 1.1E+01 1.2E+00 NA NA 0.101 90 363 no 101-20-2 Triclocarban 2 2.5E+00 1.3E+00 NA NA 0 NA 364 yes 90-02-8 Salicylaldehyde 5 6.4E+00 1.3E+00 NA NA 0.0288 170 365 no 24

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 1918-16-7 Propachlor 4 5.2E+00 1.3E+00 NA NA 0 NA 366 yes 95-38-5 1H-Imidazole-1-ethanol, 2-(8- 6 7.8E+00 1.3E+00 NA NA 0.0142 241 367 heptadecenyl)-4,5-dihydro- no 221671-62-1 SR146131 3 3.9E+00 1.3E+00 NA NA 0 NA 368 no 57-09-0 Hexadecyltrimethylammonium 6 8.0E+00 1.3E+00 NA NA 0.00076 405 369 bromide no 496-46-8 Glycoluril 5 6.7E+00 1.3E+00 NA NA 0.0207 201 370 no 2440-22-4 2-(2H-Benzotriazol-2-yl)-4- 4 5.4E+00 1.3E+00 NA NA 0.0875 103 371 methylphenol no 13826-35-2 3-Phenoxybenzenemethanol 10 1.4E+01 1.4E+00 NA NA 0.0657 117 372 no 588941-45-1 PharmaGSID_48506 2 2.8E+00 1.4E+00 NA NA NA NA 373 no 82558-50-7 Isoxaben 1 1.4E+00 1.4E+00 NA NA 0 NA 374 yes 868-85-9 Dimethyl hydrogen phosphite 6 8.3E+00 1.4E+00 NA NA 0.0148 238 375 no 97886-45-8 Dithiopyr 5 7.0E+00 1.4E+00 NA NA 0.0183 215 376 yes 1166-52-5 Dodecyl gallate 7 1.0E+01 1.4E+00 NA NA 0.000053 466 377 no 137-26-8 Thiram 2 2.9E+00 1.4E+00 NA NA 0.00506 334 378 yes 124-94-7 Triamcinolone 5 7.2E+00 1.4E+00 NA NA 0.0939 97 379 no NOCAS_47334 MK-968 4 5.7E+00 1.4E+00 NA NA NA NA 380 no 122-62-3 Bis(2-ethylhexyl) decanedioate 2 2.9E+00 1.4E+00 NA NA NA NA 381 no 103055-07-8 Lufenuron 1 1.5E+00 1.5E+00 NA NA 0 NA 382 no 525-82-6 Flavone 3 4.4E+00 1.5E+00 NA NA 0.0423 145 383 no 33629-47-9 Butralin 4 5.9E+00 1.5E+00 NA NA 0.0426 144 384 yes 79983-71-4 Hexaconazole 5 7.6E+00 1.5E+00 NA NA 0.00017 423 385 no 88-04-0 4-Chloro-3,5-dimethylphenol 8 1.2E+01 1.5E+00 NA NA 0.0439 142 386 yes 121-79-9 Propyl gallate 9 1.4E+01 1.5E+00 NA NA 0.0601 125 387 no 155569-91-8 Emamectin benzoate 3 4.6E+00 1.5E+00 NA NA 0 NA 388 no 158081-99-3 CP-105696 2 3.1E+00 1.5E+00 NA NA 0 NA 389 no 53-03-2 Prednisone 4 6.2E+00 1.5E+00 NA NA 0.0991 94 390 no 99-89-8 4-Isopropylphenol 9 1.4E+01 1.5E+00 NA NA 0.021 199 391 no 99-86-5 alpha-Terpinene 7 1.1E+01 1.6E+00 NA NA 0.0161 231 392 no 1689-84-5 Bromoxynil 4 6.3E+00 1.6E+00 NA NA 0 NA 393 yes 161326-34-7 Fenamidone 5 7.8E+00 1.6E+00 NA NA 0.0164 228 394 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 120-95-6 2,4-Bis(2-methylbutan-2-yl)phenol 3 4.7E+00 1.6E+00 NA NA 0.00528 330 395 no 118-79-6 2,4,6-Tribromophenol 3 4.8E+00 1.6E+00 NA NA 0 NA 396 no NOCAS_47351 SSR240612 4 6.4E+00 1.6E+00 NA NA 0.00262 373 397 no 603-35-0 Triphenylphosphine 8 1.3E+01 1.6E+00 NA NA 0.0652 119 398 no 463-40-1 Linolenic acid 3 4.8E+00 1.6E+00 NA NA 0.00166 394 399 no 81-90-3 Phenolphthalin 4 6.4E+00 1.6E+00 NA NA 0.0459 138 400 no 88-60-8 2-tert-Butyl-5-methylphenol 5 8.1E+00 1.6E+00 NA NA 0.0402 149 401 no 88-24-4 2,2'-Methylenebis(ethyl-6-tert- 4 6.5E+00 1.6E+00 NA NA 0 NA 402 butylphenol) no 121552-61-2 Cyprodinil 4 6.5E+00 1.6E+00 NA NA 0.0356 156 403 yes 68-26-8 Retinol 2 3.3E+00 1.6E+00 NA NA 0.00014 426 404 no 2044-64-6 N,N-Dimethylacetoacetamide 1 1.6E+00 1.6E+00 NA NA 0 NA 405 no 115-32-2 Dicofol 7 1.2E+01 1.6E+00 very_weak NA 0 NA 406 yes 333-41-5 Diazinon 5 8.3E+00 1.7E+00 NA NA 0.0237 190 407 yes NOCAS_47362 SSR150106 3 5.0E+00 1.7E+00 NA NA NA NA 408 no 210880-92-5 Clothianidin 1 1.7E+00 1.7E+00 NA NA 0 NA 409 no 40487-42-1 Pendimethalin 8 1.3E+01 1.7E+00 NA NA 0.0656 118 410 yes 135-20-6 Cupferron 4 6.8E+00 1.7E+00 NA NA 0.0224 195 411 no 1114-71-2 Pebulate 2 3.4E+00 1.7E+00 NA NA 0.00391 350 412 yes 645-56-7 4-Propylphenol 8 1.4E+01 1.7E+00 NA NA 0.0275 174 413 no 484-17-3 9-Phenanthrol 5 8.6E+00 1.7E+00 NA NA 0 NA 414 no 13071-79-9 Terbufos 6 1.1E+01 1.8E+00 NA NA 0.0482 137 415 yes 141517-21-7 Trifloxystrobin 3 5.3E+00 1.8E+00 NA NA 0 NA 416 yes 110-97-4 Diisopropanolamine 5 8.9E+00 1.8E+00 NA NA 0.0651 120 417 no NOCAS_48507 PharmaGSID_48507 4 7.2E+00 1.8E+00 NA NA NA NA 418 no 678-39-7 1,1,2,2-Tetrahydroperfluoro-1- 2 3.7E+00 1.8E+00 NA NA 0.0146 239 419 decanol no 117-80-6 Dichlone 3 5.5E+00 1.8E+00 NA NA 0 NA 420 yes 131-18-0 Dipentyl phthalate 6 1.1E+01 1.9E+00 NA NA 0.0125 250 421 no 84-69-5 Diisobutyl phthalate 7 1.3E+01 1.9E+00 NA NA 0.0283 172 422 no NOCAS_47383 AVE3247 1 1.9E+00 1.9E+00 NA NA NA NA 423 no 133855-98-8 Epoxiconazole 8 1.5E+01 1.9E+00 NA NA 0 NA 424 no 26

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 2321-07-5 Fluorescein 6 1.1E+01 1.9E+00 NA NA 0.00451 344 425 no 69-74-9 Cytarabine hydrochloride 5 9.6E+00 1.9E+00 NA NA 0.0289 169 426 no 8007-70-3 Anise oil 10 1.9E+01 1.9E+00 NA NA 0.0384 154 427 no 96-70-8 2-tert-Butyl-4-ethylphenol 4 7.8E+00 1.9E+00 NA NA 0.0193 209 428 no 79241-46-6 Fluazifop-P-butyl 4 7.8E+00 2.0E+00 NA NA 0.0272 177 429 yes 43121-43-3 Triadimefon 4 7.9E+00 2.0E+00 NA NA 0.0039 351 430 yes 43222-48-6 Difenzoquat metilsulfate 3 6.0E+00 2.0E+00 NA NA 0.0001 437 431 yes 39515-41-8 Fenpropathrin 4 8.0E+00 2.0E+00 NA NA 0.0117 261 432 yes 72-54-8 p,p'-DDD 7 1.4E+01 2.0E+00 NA NA 0.0728 113 433 no 86479-06-3 Hexaflumuron 1 2.0E+00 2.0E+00 NA NA 1.4E-21 481 434 yes 53939-28-9 (Z)-11-Hexadecenal 4 8.2E+00 2.0E+00 NA NA 0.0879 102 435 yes 88-30-2 3-Trifluoromethyl-4-nitrophenol 8 1.6E+01 2.1E+00 NA NA 0.00604 319 436 yes 1861-40-1 Benfluralin 5 1.0E+01 2.1E+00 NA NA 0.0398 151 437 yes 72490-01-8 Fenoxycarb 4 8.5E+00 2.1E+00 NA NA 0 NA 438 yes 97-00-7 1-Chloro-2,4-dinitrobenzene 4 8.5E+00 2.1E+00 NA NA 0 NA 439 yes 148-79-8 Thiabendazole 1 2.1E+00 2.1E+00 NA NA 0 NA 440 yes 117718-60-2 Thiazopyr 5 1.1E+01 2.2E+00 NA NA 0.00886 286 441 yes 117-81-7 Di(2-ethylhexyl) phthalate 2 4.3E+00 2.2E+00 very_weak NA 0 NA 442 no 39905-57-2 4-Hexyloxyaniline 4 8.9E+00 2.2E+00 NA NA 0.00257 374 443 no 68959-20-6 Disiquonium chloride 4 8.9E+00 2.2E+00 NA NA 0.0121 257 444 yes 22248-79-9 Z-Tetrachlorvinphos 3 6.7E+00 2.2E+00 NA NA 0 NA 445 yes 78-40-0 Triethyl phosphate 1 2.3E+00 2.3E+00 NA NA 0 NA 446 no 584-79-2 Allethrin 3 7.0E+00 2.3E+00 NA NA 0 NA 447 yes 827-21-4 Benzenesulfonic acid, 2,4-dimethyl-, 5 1.2E+01 2.3E+00 NA NA 0.0123 254 448 sodium salt no 78-07-9 Ethyltriethoxysilane 1 2.4E+00 2.4E+00 NA NA 0 NA 449 no 8001-54-5 Benzalkonium chloride 4 9.5E+00 2.4E+00 NA NA 0 NA 450 yes 97-54-1 Isoeugenol 9 2.2E+01 2.4E+00 NA NA 0.0124 252 451 no 2457-01-4 Barium bis(2-ethylhexanoate) 4 9.6E+00 2.4E+00 NA NA 0.011 268 452 no 7664-38-2 Phosphoric acid 2 4.9E+00 2.4E+00 NA NA 0.0069 312 453 yes 1724-39-6 Cyclododecanol 5 1.2E+01 2.5E+00 NA NA 0.0221 196 454 no 29232-93-7 Pirimiphos-methyl 5 1.2E+01 2.5E+00 NA NA 0.0176 221 455 yes 27

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 169590-42-5 Celecoxib 4 9.9E+00 2.5E+00 NA NA 0 NA 456 no 52-68-6 Trichlorfon 7 1.7E+01 2.5E+00 NA NA 0.0405 148 457 yes 361377-29-9 Fluoxastrobin 3 7.5E+00 2.5E+00 NA NA 0 NA 458 no 2467-02-9 Bisphenol F 6 1.5E+01 2.5E+00 NA NA 0.0303 165 459 no 88671-89-0 Myclobutanil 2 5.1E+00 2.6E+00 NA NA 0 NA 460 yes 120116-88-3 Cyazofamid 4 1.0E+01 2.6E+00 NA NA 0 NA 461 no 1596-84-5 Daminozide 5 1.3E+01 2.6E+00 NA NA 0.0318 162 462 yes 92-84-2 Phenothiazine 4 1.0E+01 2.6E+00 NA NA 0.0122 256 463 yes 95-50-1 1,2-Dichlorobenzene 3 7.8E+00 2.6E+00 NA NA 0.00153 398 464 yes 84-74-2 Dibutyl phthalate 9 2.4E+01 2.6E+00 very_weak Negative 0.0265 182 465 yes 199171-88-5 CP-401387 2 5.3E+00 2.6E+00 NA NA NA NA 466 no 66-71-7 1,10-Phenanthroline 3 8.0E+00 2.7E+00 NA NA 0 NA 467 no 143-74-8 Phenol red 7 1.9E+01 2.7E+00 NA NA 0.0409 146 468 no 87-61-6 1,2,3-Trichlorobenzene 1 2.7E+00 2.7E+00 NA NA 0 NA 469 no 122-99-6 2-Phenoxyethanol 1 2.7E+00 2.7E+00 NA NA 0 NA 470 no 59-50-7 4-Chloro-3-methylphenol 7 1.9E+01 2.7E+00 NA NA 0.0285 171 471 yes 60-09-3 4-Aminoazobenzene 9 2.4E+01 2.7E+00 NA NA 0.0658 116 472 no 55219-65-3 Triadimenol 6 1.6E+01 2.7E+00 NA NA 0.0188 212 473 yes 127-25-3 Methyl abietate 3 8.3E+00 2.8E+00 NA NA 0.00607 318 474 no 1134-23-2 Cycloate 2 5.5E+00 2.8E+00 NA NA 0 NA 475 yes 105512-06-9 Clodinafop-propargyl mixt. 1 2.8E+00 2.8E+00 NA NA 0 NA 476 yes 118-56-9 3,3,5-Trimethylcyclohexyl salicylate 5 1.4E+01 2.8E+00 NA NA 0.0217 197 477 no 117-99-7 2-Hydroxybenzophenone 5 1.4E+01 2.9E+00 NA NA 0.0157 233 478 no 82-68-8 Pentachloronitrobenzene 3 8.8E+00 2.9E+00 NA NA 0.00362 355 479 yes 19666-30-9 Oxadiazon 3 8.8E+00 2.9E+00 NA NA 0 NA 480 yes 62-56-6 Thiourea 1 3.0E+00 3.0E+00 NA NA 0 NA 481 no 35554-44-0 Imazalil 3 9.0E+00 3.0E+00 NA NA 8.3E-06 476 482 yes NOCAS_47349 AVE8488 2 6.0E+00 3.0E+00 NA NA NA NA 483 no 90-43-7 2-Phenylphenol 4 1.2E+01 3.0E+00 NA NA 0.00543 327 484 yes 101-61-1 4,4'-Methylenebis(N,N- 3 9.0E+00 3.0E+00 NA NA 0.0518 132 485 dimethylaniline) no 2491-38-5 2-Bromo-4-hydroxyacetophenone 5 1.5E+01 3.0E+00 NA NA 0.0164 229 486 yes 28

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 122-14-5 Fenitrothion 3 9.2E+00 3.1E+00 NA NA 0.000054 464 487 yes 124-07-2 Octanoic acid 5 1.6E+01 3.1E+00 NA NA 0.00457 340 488 yes 137-30-4 Ziram 4 1.3E+01 3.1E+00 NA NA 0 NA 489 yes 115-77-5 Pentaerythritol 1 3.2E+00 3.2E+00 NA NA 0 NA 490 no 1929-73-3 2,4-D-Butotyl 2 6.4E+00 3.2E+00 NA NA 0 NA 491 yes 1024-57-3 Heptachlor epoxide 3 9.6E+00 3.2E+00 NA NA 0.00739 306 492 no 94-46-2 Isopentyl benzoate 2 6.4E+00 3.2E+00 NA NA 0.00166 395 493 no 179465-71-5 CJ-013790 4 1.3E+01 3.2E+00 NA NA 0.0185 213 494 no 120-83-2 2,4-Dichlorophenol 5 1.6E+01 3.3E+00 NA NA 0.00424 346 495 no 58-93-5 Hydrochlorothiazide 1 3.3E+00 3.3E+00 NA NA 0 NA 496 no 104795-68-8 CI-959 4 1.3E+01 3.3E+00 NA NA 0 NA 497 no 94361-06-5 Cyproconazole 5 1.7E+01 3.3E+00 NA NA 0.0268 181 498 yes 52-86-8 Haloperidol 2 6.7E+00 3.4E+00 inactive NA 0.00598 320 499 no 103-76-4 1-Piperazineethanol 1 3.4E+00 3.4E+00 NA NA 0 NA 500 no 42874-03-3 Oxyfluorfen 2 6.8E+00 3.4E+00 NA NA 0 NA 501 yes NOCAS_47379 SSR126768 3 1.0E+01 3.4E+00 NA NA NA NA 502 no 6259-76-3 Hexyl salicylate 5 1.7E+01 3.4E+00 NA NA 0.0173 224 503 no 40649-36-3 4-Propylcyclohexanone 2 6.8E+00 3.4E+00 NA NA 0.000059 461 504 no 143-07-7 Dodecanoic acid 2 6.9E+00 3.4E+00 NA NA 0 NA 505 no 1434-54-4 Pregnenolone carbonitrile 2 6.9E+00 3.4E+00 NA NA 0 NA 506 no 154-42-7 6-Thioguanine 2 6.9E+00 3.5E+00 NA NA 0 NA 507 no 112-63-0 Methyl linoleate 2 6.9E+00 3.5E+00 NA NA 0 NA 508 no 90-15-3 1-Naphthol 6 2.1E+01 3.5E+00 NA NA 0.0232 192 509 no 103-11-7 2-Ethylhexyl acrylate 1 3.5E+00 3.5E+00 NA NA 0 NA 510 no 4602-84-0 Farnesol 5 1.8E+01 3.5E+00 NA NA 0.0162 230 511 yes 605-45-8 Diisopropyl phthalate 5 1.8E+01 3.5E+00 NA NA 0.00932 283 512 no 298-02-2 Phorate 5 1.8E+01 3.5E+00 NA NA 0.0181 218 513 yes 75330-75-5 Lovastatin 2 7.1E+00 3.5E+00 NA NA 0.000076 447 514 no 95737-68-1 Pyriproxyfen 3 1.1E+01 3.6E+00 NA NA 0.0259 183 515 yes 1763-23-1 PFOS 5 1.8E+01 3.6E+00 NA NA 0.00026 418 516 no 825643-57-0 PharmaGSID_48513 3 1.1E+01 3.6E+00 NA NA NA NA 517 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 744-45-6 Diphenyl isophthalate 3 1.1E+01 3.6E+00 NA NA 0.035 158 518 no 579-66-8 2,6-Diethylaniline 3 1.1E+01 3.6E+00 NA NA 0 NA 519 no 2144-53-8 Tridecafluorohexylethyl 3 1.1E+01 3.7E+00 NA NA 0.0134 248 520 methacrylate no 71751-41-2 Abamectin 2 7.4E+00 3.7E+00 NA NA 0 NA 521 yes 51-03-6 Piperonyl butoxide 3 1.1E+01 3.7E+00 NA NA 0.00231 381 522 yes 55283-68-6 Ethalfluralin 4 1.5E+01 3.8E+00 NA NA 0.0346 159 523 yes 104-13-2 4-Butylaniline 3 1.2E+01 3.9E+00 NA NA 0.00355 356 524 no 120-14-9 Veratraldehyde 3 1.2E+01 3.9E+00 NA NA 0.0572 126 525 no 6706-59-8 L-Glucitol 3 1.2E+01 3.9E+00 NA NA 0.000072 449 526 no NOCAS_47346 SSR162369 1 3.9E+00 3.9E+00 NA NA 0.000062 457 527 no 7773-06-0 Ammonium sulfamate 1 4.0E+00 4.0E+00 NA NA 0 NA 528 yes 87818-31-3 Cinmethylin 4 1.6E+01 4.0E+00 NA NA 0.0107 270 529 no 51630-58-1 Fenvalerate 3 1.2E+01 4.0E+00 NA NA 0.00468 338 530 yes 82657-04-3 Bifenthrin 3 1.2E+01 4.0E+00 NA NA 0.000069 453 531 yes 2921-88-2 Chlorpyrifos 5 2.0E+01 4.0E+00 NA NA 0.0125 251 532 yes NOCAS_47377 AVE6324 4 1.6E+01 4.1E+00 NA NA 0.0137 246 533 no 107-87-9 2-Pentanone 3 1.2E+01 4.1E+00 NA NA 0.00202 387 534 no 110-25-8 Oleyl sarcosine 3 1.3E+01 4.2E+00 NA NA 0 NA 535 no 120-65-0 2-((Dimethylamino)methyl)phenol 1 4.2E+00 4.2E+00 NA NA 7.5E-06 477 536 no NOCAS_48509 PharmaGSID_48509 4 1.7E+01 4.2E+00 NA NA NA NA 537 no 3025-30-7 Ethyl (2E,4Z)-deca-2,4-dienoate 4 1.7E+01 4.3E+00 NA NA 0 NA 538 no 311-45-5 Paraoxon 2 8.7E+00 4.3E+00 NA NA 0 NA 539 no 131860-33-8 Azoxystrobin 3 1.3E+01 4.4E+00 NA NA 0.00013 427 540 yes 13684-63-4 Phenmedipham 1 4.4E+00 4.4E+00 NA NA 0 NA 541 yes 25155-30-0 Sodium dodecylbenzenesulfonate 5 2.2E+01 4.4E+00 NA NA 0 NA 542 yes 131-17-9 Diallyl phthalate 8 3.6E+01 4.5E+00 NA NA 0.014 242 543 no 52315-07-8 Cypermethrin 3 1.4E+01 4.5E+00 NA NA 0.0138 245 544 yes 108-46-3 Resorcinol 4 1.8E+01 4.5E+00 NA NA 0.00321 364 545 no 106-30-9 Ethyl heptanoate 3 1.4E+01 4.5E+00 NA NA 0.0173 225 546 no 49562-28-9 Fenofibrate 4 1.8E+01 4.6E+00 NA NA 0.000021 472 547 no 3164-85-0 Potassium 2-ethylhexanoate 3 1.4E+01 4.6E+00 NA NA 0.00456 342 548 no 30

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 98967-40-9 Flumetsulam 2 9.2E+00 4.6E+00 NA NA NA NA 549 yes 77-71-4 5,5-Dimethylhydantoin 3 1.4E+01 4.6E+00 NA NA 0 NA 550 no 2409-55-4 2-tert-Butyl-4-methylphenol 3 1.4E+01 4.6E+00 NA NA 0 NA 551 no 63-25-2 Carbaryl 4 1.9E+01 4.6E+00 NA NA 0.00877 288 552 yes 2110-18-1 2-(3-Phenylpropyl)pyridine 4 1.9E+01 4.7E+00 NA NA 0.0171 226 553 no 140-31-8 1-(2-Aminoethyl)piperazine 2 9.3E+00 4.7E+00 NA NA 0.0078 298 554 no 85509-19-9 Flusilazole 3 1.4E+01 4.7E+00 NA NA 0 NA 555 no 7212-44-4 Nerolidol 2 9.4E+00 4.7E+00 NA NA 0 NA 556 yes 451-40-1 1,2-Diphenylethanone 5 2.4E+01 4.7E+00 NA NA 0.0227 194 557 no 115-39-9 Bromophenol blue 3 1.4E+01 4.7E+00 NA NA 0 NA 558 no 133-07-3 Folpet 3 1.4E+01 4.8E+00 NA NA 0 NA 559 yes 112281-77-3 Tetraconazole 4 1.9E+01 4.8E+00 NA NA 0 NA 560 no 2310-17-0 Phosalone 2 9.6E+00 4.8E+00 NA NA 0.00011 434 561 yes 4344-55-2 4-Butyloxyaniline 3 1.5E+01 4.8E+00 NA NA 0.00848 290 562 no 7758-19-2 Sodium chlorite 1 4.9E+00 4.9E+00 NA NA NA NA 563 yes 67-30-1 Tetrac 4 2.0E+01 5.0E+00 NA NA 0 NA 564 no 1610-18-0 Prometon 2 1.0E+01 5.0E+00 NA NA 0 NA 565 yes 5437-45-6 Benzyl bromoacetate 2 1.0E+01 5.1E+00 NA NA 0.00188 392 566 yes 115-95-7 Linalyl acetate 2 1.0E+01 5.1E+00 NA NA 0 NA 567 no 86-30-6 N-Nitrosodiphenylamine 5 2.5E+01 5.1E+00 NA NA 0.0102 272 568 no 156052-68-5 Zoxamide 3 1.5E+01 5.1E+00 NA NA 0 NA 569 yes 123-96-6 2-Octanol 2 1.0E+01 5.2E+00 NA NA 0 NA 570 no 118-58-1 Benzyl salicylate 7 3.7E+01 5.2E+00 NA NA 0.013 249 571 no 51218-45-2 Metolachlor 2 1.1E+01 5.3E+00 NA NA 0.000093 443 572 yes 493-52-7 Methyl red 2 1.1E+01 5.3E+00 NA NA 0 NA 573 no 142-31-4 Sodium octyl sulfate 2 1.1E+01 5.3E+00 NA NA 0 NA 574 no 741-58-2 Bensulide 3 1.6E+01 5.3E+00 NA NA 0 NA 575 yes 26040-51-7 Bis(2-ethylhexyl) 1 5.3E+00 5.3E+00 NA NA 0.00036 415 576 tetrabromophthalate no 104-54-1 3-Phenyl-2-propen-1-ol 4 2.1E+01 5.4E+00 NA NA 0.00786 296 577 yes 647-42-7 3,3,4,4,5,5,6,6,7,7,8,8,8- 2 1.1E+01 5.4E+00 NA NA 0.007 311 578 Tridecafluorooctan-1-ol no 31

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 78-63-7 2,5-Dimethyl-2,5-di-(tert- 3 1.6E+01 5.4E+00 NA NA 0.0159 232 579 butylperoxy)hexane no NOCAS_47305 CP-608039 1 5.4E+00 5.4E+00 NA NA NA NA 580 no 58-89-9 Lindane 3 1.6E+01 5.4E+00 NA NA 0.00306 367 581 yes 335-76-2 PFDA 3 1.6E+01 5.4E+00 NA NA 0.000014 474 582 no 23564-06-9 Thiophanate 2 1.1E+01 5.5E+00 NA NA 0 NA 583 yes 54593-83-8 Chlorethoxyfos 5 2.7E+01 5.5E+00 NA NA 0.0203 203 584 yes 2016-57-1 1-Decanamine 1 5.5E+00 5.5E+00 NA NA 0 NA 585 no 67-20-9 Nitrofurantoin 4 2.2E+01 5.5E+00 NA NA 1.4E-06 479 586 no 2550-40-5 Dicyclohexyl disulfide 4 2.2E+01 5.6E+00 NA NA 0.00737 307 587 no 13171-00-1 1-(6-tert-Butyl-1,1-dimethyl-2,3- 2 1.1E+01 5.6E+00 NA NA 0 NA 588 dihydro-1H-inden-4-yl)ethanone no 118-71-8 Maltol 1 5.6E+00 5.6E+00 NA NA 0 NA 589 no 705-60-2 (2-Nitro-1-propenyl)benzene 3 1.7E+01 5.6E+00 NA NA 0.000043 469 590 no 122-42-9 Propham 1 5.6E+00 5.6E+00 NA NA 0 NA 591 yes 79902-63-9 Simvastatin 1 5.7E+00 5.7E+00 NA NA 0.000071 451 592 no 290352-28-2 CP-634384 4 2.3E+01 5.8E+00 NA NA 0.00739 305 593 no 26264-06-2 Calcium dodecylbenzene sulfonate 4 2.3E+01 5.8E+00 NA NA 0 NA 594 no 2386-87-0 UT-632 2 1.2E+01 5.8E+00 NA NA 0.00355 357 595 no 1477-55-0 1,3-Benzenedimethanamine 1 5.8E+00 5.8E+00 NA NA 0 NA 596 no 309-00-2 Aldrin 2 1.2E+01 5.9E+00 NA NA 0.0001 439 597 yes 668981-02-0 CP-863187 3 1.8E+01 5.9E+00 NA NA 0 NA 598 no 26002-80-2 Phenothrin 2 1.2E+01 6.0E+00 NA NA 0 NA 599 yes 94-91-7 N,N'-Disalicylidene-1,2- 2 1.2E+01 6.0E+00 NA NA 0 NA 600 diaminopropane no 142-18-7 1-Monolaurin 2 1.2E+01 6.0E+00 NA NA 0 NA 601 no 144-62-7 Oxalic acid 4 2.4E+01 6.1E+00 NA NA 0.00766 300 602 yes 334-48-5 Decanoic acid 3 1.9E+01 6.2E+00 NA NA 0.0001 438 603 yes 127-51-5 alpha-Isomethylionone 3 1.9E+01 6.2E+00 NA NA 0.0185 214 604 no 4638-48-6 5-Chlorosalicylanilide 3 1.9E+01 6.2E+00 NA NA 0 NA 605 no NOCAS_47387 SAR102779 4 2.5E+01 6.3E+00 NA NA 0.000059 460 606 no 134-03-2 Sodium L-ascorbate 1 6.3E+00 6.3E+00 NA NA 0 NA 607 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 14351-66-7 Sodium abietate 3 1.9E+01 6.3E+00 NA NA 0.00244 379 608 no 2353-45-9 FD&C Green No. 3 3 1.9E+01 6.3E+00 NA NA 0 NA 609 no NOCAS_47708 Igepal CO-890 4 2.5E+01 6.4E+00 NA NA NA NA 610 no 123-01-3 Dodecylbenzene 2 1.3E+01 6.4E+00 NA NA NA NA 611 no 101-55-3 p-Bromodiphenyl ether 4 2.5E+01 6.4E+00 NA NA 0.00744 304 612 no 78-48-8 Tribufos 2 1.3E+01 6.4E+00 NA NA 0.000038 471 613 yes 1825-21-4 Pentachloroanisole 5 3.2E+01 6.4E+00 NA NA 0 NA 614 no 10453-86-8 Resmethrin 3 1.9E+01 6.4E+00 NA NA 0.00944 278 615 yes 141-22-0 9-Octadecenoic acid, 12-hydroxy-, 3 1.9E+01 6.4E+00 NA NA 0 NA 616 (9Z,12R)- no 313994-79-5 MK-578 1 6.5E+00 6.5E+00 NA NA 0 NA 617 no 156-10-5 4-Nitrosodiphenylamine 4 2.6E+01 6.6E+00 NA NA 0.028 173 618 no 16079-88-2 Bromo-3-chloro-5,5- 1 6.6E+00 6.6E+00 NA NA 0 NA 619 dimethylhydantoin yes 26225-79-6 Ethofumesate 4 2.6E+01 6.6E+00 NA NA 0.00195 389 620 yes 6152-33-6 Sodium 2-phenylphenate 2 1.3E+01 6.6E+00 NA NA 0 NA 621 tetrahydrate no 99-76-3 Methylparaben 5 3.3E+01 6.6E+00 NA NA 0.00684 314 622 yes 91-53-2 Ethoxyquin 3 2.0E+01 6.7E+00 NA NA 0.00011 433 623 yes 59-87-0 Nitrofurazone 3 2.0E+01 6.7E+00 NA NA 0 NA 624 no 66230-04-4 Esfenvalerate 1 6.8E+00 6.8E+00 NA NA 0 NA 625 yes 22047-49-0 2-Ethylhexyl octadecanoate 3 2.1E+01 6.9E+00 NA NA 0 NA 626 no 253450-09-8 Besonprodil 2 1.4E+01 6.9E+00 NA NA 0 NA 627 no 81406-37-3 Fluroxypyr-meptyl 3 2.1E+01 7.0E+00 NA NA 0.00936 282 628 yes 489-01-0 2,6-Di-tert-butyl-4-methoxyphenol 3 2.1E+01 7.0E+00 NA NA 0.00583 322 629 no 69327-76-0 Buprofezin 3 2.1E+01 7.0E+00 NA NA 0 NA 630 yes 138-22-7 Butyl lactate 1 7.0E+00 7.0E+00 NA NA 0 NA 631 no 13301-61-6 C.I. Disperse Orange 37 1 7.1E+00 7.1E+00 NA NA 0.00013 429 632 no 88-75-5 2-Nitrophenol 1 7.1E+00 7.1E+00 NA NA 0 NA 633 no 120-80-9 Catechol 3 2.1E+01 7.1E+00 NA NA 0.0155 235 634 no 27138-31-4 Di(propylene glycol) dibenzoate 3 2.1E+01 7.1E+00 NA NA 0.00955 277 635 no 6381-77-7 Sodium erythorbate (1:1) 3 2.2E+01 7.2E+00 NA NA 0 NA 636 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 88-58-4 2,5-Di-tert-butylbenzene-1,4-diol 3 2.2E+01 7.3E+00 NA NA 0 NA 637 no 95-95-4 2,4,5-Trichlorophenol 4 2.9E+01 7.3E+00 NA NA 0.00613 317 638 yes 111-42-2 Diethanolamine 1 7.3E+00 7.3E+00 NA NA 0 NA 639 no 1333-39-7 Phenolsulfonic acid 1 7.4E+00 7.4E+00 NA NA 0 NA 640 no NOCAS_47248 CI-1018 1 7.4E+00 7.4E+00 NA NA NA NA 641 no 2425-77-6 2-Hexyl-1-decanol 2 1.5E+01 7.5E+00 NA NA 0.0021 386 642 no 26530-20-1 Octhilinone 2 1.5E+01 7.5E+00 NA NA 0 NA 643 yes 31218-83-4 Propetamphos 2 1.5E+01 7.5E+00 NA NA 0 NA 644 yes 122-66-7 1,2-Diphenylhydrazine 2 1.5E+01 7.6E+00 NA NA 0 NA 645 no 3825-26-1 PFOA, ammonium salt 3 2.3E+01 7.6E+00 NA NA 0 NA 646 no 90-00-6 2-Ethylphenol 1 7.6E+00 7.6E+00 NA NA 0 NA 647 no 930-55-2 N-Nitrosopyrrolidine 3 2.3E+01 7.6E+00 NA NA 0.00171 393 648 no 123-17-1 2,6,8-Trimethyl-4-nonanol 2 1.5E+01 7.7E+00 NA NA 0.00239 380 649 no 108-21-4 Isopropyl acetate 4 3.1E+01 7.7E+00 NA NA 0.0152 237 650 yes 55-38-9 Fenthion 3 2.3E+01 7.7E+00 NA NA 0.00263 372 651 yes 264618-44-2 SSR146977 2 1.6E+01 7.8E+00 NA NA 0 NA 652 no 5116-94-9 Monotridecyl phosphate 3 2.4E+01 7.9E+00 NA NA 0 NA 653 no 14371-10-9 (2E)-3-Phenylprop-2-enal 3 2.4E+01 7.9E+00 NA NA 0.0167 227 654 no 80-26-2 alpha-Terpinyl acetate 3 2.4E+01 8.1E+00 NA NA 0.00943 279 655 no 89-87-2 1,3-Dimethyl-4-nitrobenzene 2 1.6E+01 8.1E+00 NA NA 0.0121 258 656 no 368832-42-2 CP-728663 3 2.4E+01 8.1E+00 NA NA 0 NA 657 no 1570-64-5 4-Chloro-2-methylphenol 6 4.9E+01 8.2E+00 NA NA 0.0109 269 658 no 1303-11-3 Indium arsenide 2 1.6E+01 8.2E+00 NA NA 0 NA 659 no 122-40-7 Pentylcinnamaldehyde 3 2.5E+01 8.2E+00 NA NA 0.00842 291 660 no 141-04-8 Diisobutyl adipate 1 8.2E+00 8.2E+00 NA NA 0 NA 661 no 97-78-9 N-Dodecanoyl-N-methylglycine 2 1.7E+01 8.4E+00 NA NA 0 NA 662 no 15299-99-7 Napropamide 3 2.5E+01 8.4E+00 NA NA 0 NA 663 yes 174185-16-1 FR167356 2 1.7E+01 8.5E+00 NA NA NA NA 664 no 80-54-6 3-(4-tert-Butylphenyl)-2- 3 2.5E+01 8.5E+00 NA NA 0.0022 382 665 methylpropanal no 159138-81-5 Cariporide mesylate 4 3.4E+01 8.5E+00 NA NA 0.0124 253 666 no 1192-52-5 4,5-Dichloro-3H-1,2-dithiol-3-one 1 8.5E+00 8.5E+00 NA NA 0 NA 667 yes 34

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 60-33-3 Linoleic acid 3 2.6E+01 8.6E+00 NA NA 0 NA 668 no 134523-03-8 Atorvastatin calcium 2 1.7E+01 8.6E+00 NA NA 0 NA 669 no 618-45-1 3-Isopropylphenol 5 4.3E+01 8.7E+00 NA NA 0.00783 297 670 no 769-92-6 4-tert-Butylaniline 3 2.6E+01 8.7E+00 NA NA 0.00506 333 671 no 2243-62-1 1,5-Naphthalenediamine 1 8.7E+00 8.7E+00 NA NA 0 NA 672 no 101-77-9 4,4'-Methylenedianiline 4 3.5E+01 8.7E+00 NA NA 0.00885 287 673 no 10081-67-1 4-(2-Phenylpropan-2-yl)-N-[4-(2- 2 1.8E+01 8.8E+00 NA NA 0 NA 674 phenylpropan-2-yl)phenyl]aniline no 39236-46-9 Imidazolidinyl urea 3 2.6E+01 8.8E+00 NA NA 0.00189 391 675 no 6624-73-3 Pentane-1,5-diyl dibenzoate 3 2.6E+01 8.8E+00 NA NA 0 NA 676 no 4940-11-8 2-Ethyl-3-hydroxy-4H-pyran-4-one 1 8.8E+00 8.8E+00 NA NA 0 NA 677 no 75-86-5 2-Hydroxy-2-methylpropanenitrile 3 2.7E+01 8.9E+00 NA NA 0.00499 335 678 no 151506-44-4 FR140423 4 3.6E+01 8.9E+00 NA NA NA NA 679 no 88-18-6 2-tert-Butylphenol 2 1.8E+01 9.0E+00 NA NA 0.00325 362 680 no 101-84-8 Diphenyl oxide 1 9.0E+00 9.0E+00 NA NA 0 NA 681 no 116-25-6 1-(Hydroxymethyl)-5,5- 5 4.5E+01 9.0E+00 NA NA 0.00936 281 682 dimethylhydantoin yes 1335-46-2 Ionone, methyl- 2 1.8E+01 9.0E+00 NA NA 0 NA 683 no 1897-45-6 Chlorothalonil 3 2.7E+01 9.0E+00 NA NA 0 NA 684 yes 131807-57-3 Famoxadone 2 1.8E+01 9.1E+00 NA NA 0 NA 685 no 106-45-6 4-Thiocresol 1 9.2E+00 9.2E+00 NA NA 0 NA 686 no 206-44-0 Fluoranthene 5 4.6E+01 9.3E+00 NA NA 0.00745 303 687 no 76-44-8 Heptachlor 1 9.3E+00 9.3E+00 NA NA 0 NA 688 yes 556-67-2 Octamethylcyclotetrasiloxane 2 1.9E+01 9.4E+00 NA NA 0 NA 689 no 17796-82-6 N-(Cyclohexylthio)phthalimide 4 3.8E+01 9.4E+00 NA NA 0.00292 369 690 no 90823-38-4 Denatonium saccharide 2 1.9E+01 9.4E+00 NA NA 0 NA 691 yes 460-00-4 1-Bromo-4-fluorobenzene 2 1.9E+01 9.4E+00 NA NA 0 NA 692 no 4707-47-5 Methyl 2,4-dihydroxy-3,6- 4 3.8E+01 9.4E+00 NA NA 0.00793 295 693 dimethylbenzoate no 78-96-6 1-Amino-2-propanol 1 9.5E+00 9.5E+00 NA NA 0 NA 694 no 25812-30-0 Gemfibrozil 2 1.9E+01 9.5E+00 NA NA 0 NA 695 no 35691-65-7 1,2-Dibromo-2,4-dicyanobutane 2 1.9E+01 9.6E+00 NA NA 0 NA 696 yes

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 99-30-9 Dicloran 3 2.9E+01 9.6E+00 NA NA NA NA 697 yes 77-83-8 Ethyl methylphenylglycidate 4 3.9E+01 9.7E+00 NA NA 0.00327 361 698 no 26447-10-9 Ammonium xylene sulfonate 1 9.7E+00 9.7E+00 NA NA 0 NA 699 no 732-26-3 2,4,6-Tris(tert-butyl)phenol 3 2.9E+01 9.8E+00 NA NA 0 NA 700 no 112529-15-4 Pioglitazone hydrochloride 3 3.0E+01 9.8E+00 NA NA 0.00454 343 701 no 122-57-6 Methyl styryl ketone 2 2.0E+01 9.9E+00 NA NA 0 NA 702 no 121-39-1 Ethyl 3-phenylglycidate 1 9.9E+00 9.9E+00 NA NA 0 NA 703 no 1762-95-4 Thiocyanic acid, ammonium salt 1 1.0E+01 1.0E+01 NA NA 0 NA 704 no 25956-17-6 Allura Red C.I.16035 5 5.0E+01 1.0E+01 NA NA 0 NA 705 no 1702-17-6 Clopyralid 2 2.0E+01 1.0E+01 NA NA 0 NA 706 yes 27323-41-7 Dodecylbenzene sulfonate 2 2.0E+01 1.0E+01 NA NA 0.0075 302 707 triethanolamine (1:1) yes 2870-32-8 C.I. Direct Yellow 12 2 2.0E+01 1.0E+01 NA NA 0 NA 708 no 99-07-0 3-Dimethylaminophenol 3 3.1E+01 1.0E+01 NA NA 0.00715 309 709 no 532-27-4 2-Chloroacetophenone 3 3.1E+01 1.0E+01 NA NA 0.0137 247 710 no 77501-63-4 Lactofen 3 3.1E+01 1.0E+01 NA NA 0 NA 711 yes 129-00-0 Pyrene 3 3.1E+01 1.0E+01 NA NA 0 NA 712 no 25550-98-5 Diisodecylphenyl phosphite 2 2.1E+01 1.0E+01 NA NA 0 NA 713 no 3391-86-4 1-Octen-3-ol 2 2.1E+01 1.0E+01 NA NA 0 NA 714 yes 50-55-5 Reserpine 2 2.1E+01 1.1E+01 inactive NA 0 NA 715 no 3147-75-9 Octrizole 3 3.2E+01 1.1E+01 NA NA 0 NA 716 no 51229-78-8 Chloroallyl methenamine chloride 2 2.1E+01 1.1E+01 NA NA 0.00109 403 717 yes 76578-14-8 Quizalofop-ethyl 1 1.1E+01 1.1E+01 NA NA 0 NA 718 yes 117337-19-6 Fluthiacet-methyl 1 1.1E+01 1.1E+01 NA NA 0 NA 719 yes 28804-88-8 Dimethylnaphthalene 2 2.2E+01 1.1E+01 NA NA 0 NA 720 yes 56-38-2 Parathion 2 2.2E+01 1.1E+01 NA NA 0 NA 721 yes 52645-53-1 Permethrin 2 2.2E+01 1.1E+01 NA NA 0 NA 722 yes 541-02-6 Decamethylcyclopentasiloxane 3 3.3E+01 1.1E+01 NA NA 0 NA 723 no 5392-40-5 3,7-Dimethyl-2,6-octadienal 2 2.2E+01 1.1E+01 NA NA 0 NA 724 no 92-52-4 Biphenyl 2 2.2E+01 1.1E+01 NA NA 0 NA 725 yes 127-41-3 alpha-Ionone 2 2.2E+01 1.1E+01 NA NA 0 NA 726 yes 139-02-6 Sodium phenolate 2 2.2E+01 1.1E+01 NA NA 0 NA 727 yes 36

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 107-13-1 Acrylonitrile 2 2.2E+01 1.1E+01 NA NA 0 NA 728 yes 68157-60-8 Forchlorfenuron 2 2.2E+01 1.1E+01 NA NA 0 NA 729 no 335-67-1 PFOA 3 3.4E+01 1.1E+01 NA NA 0 NA 730 no 122-39-4 Diphenylamine 4 4.5E+01 1.1E+01 NA NA 0.00816 294 731 yes 101-54-2 N-Phenyl-1,4-benzenediamine 2 2.3E+01 1.1E+01 NA NA 0.00022 421 732 no 344930-95-6 SSR69071 1 1.1E+01 1.1E+01 NA NA 0.0001 441 733 no 6149-03-7 Sodium 4-octylbenzenesulfonate 2 2.3E+01 1.1E+01 NA NA 0 NA 734 no 98-95-3 Nitrobenzene 2 2.3E+01 1.1E+01 NA NA NA NA 735 yes 288-88-0 1H-1,2,4-Triazole 2 2.3E+01 1.2E+01 NA NA 0.00013 428 736 no 23103-98-2 Pirimicarb 1 1.2E+01 1.2E+01 NA NA 0 NA 737 yes 101-80-4 4,4'-Oxydianiline 4 4.6E+01 1.2E+01 NA NA 0.00457 341 738 no 2008-41-5 Butylate 1 1.2E+01 1.2E+01 NA NA 0 NA 739 yes 6625-46-3 C.I. Acid Violet 12, disodium salt 3 3.5E+01 1.2E+01 NA NA 0 NA 740 no 173584-44-6 Indoxacarb 1 1.2E+01 1.2E+01 NA NA 0 NA 741 yes 94-47-3 2-Phenylethyl benzoate 3 3.5E+01 1.2E+01 NA NA 0.00552 326 742 no 941-69-5 1-Phenyl-1H-pyrrole-2,5-dione 3 3.5E+01 1.2E+01 NA NA 0 NA 743 no 584-13-4 4-Amino-1,2,4-triazole 3 3.6E+01 1.2E+01 NA NA 7.5E-09 480 744 no 586-62-9 Terpinolene 3 3.6E+01 1.2E+01 NA NA 0.00827 292 745 no 132-65-0 Dibenzothiophene 3 3.6E+01 1.2E+01 NA NA 0.00373 354 746 no NOCAS_47325 SB413217A 2 2.4E+01 1.2E+01 NA NA 0.00009 444 747 no 602-01-7 2,3-Dinitrotoluene 2 2.4E+01 1.2E+01 NA NA 0.000061 458 748 no 552-30-7 Trimellitic anhydride 2 2.4E+01 1.2E+01 NA NA 0 NA 749 no 111-84-2 Nonane 2 2.4E+01 1.2E+01 NA NA 0 NA 750 no 24157-81-1 2,6-Diisopropylnaphthalene 1 1.2E+01 1.2E+01 NA NA 0.000063 456 751 yes 120-12-7 Anthracene 2 2.4E+01 1.2E+01 NA NA 0.0112 267 752 no 1323-19-9 Sodium 2,4,7-tri(propan-2- 2 2.4E+01 1.2E+01 NA NA 0 NA 753 yl)naphthalene-1-sulfonate no 15619-48-4 1-Benzylquinolinium chloride 3 3.6E+01 1.2E+01 NA NA NA NA 754 no 1760-24-3 N-[3-(Trimethoxysilyl)propyl]ethane- 1 1.2E+01 1.2E+01 NA NA 0 NA 755 1,2-diamine no 66332-96-5 Flutolanil 1 1.2E+01 1.2E+01 NA NA 0 NA 756 yes 1330-78-5 Tricresyl phosphate 1 1.2E+01 1.2E+01 NA NA 0 NA 757 no 37

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 129299-90-7 Fabesetron hydrochloride 4 4.9E+01 1.2E+01 NA NA NA NA 758 no 97-53-0 Eugenol 2 2.5E+01 1.2E+01 NA NA 0 NA 759 yes 135080-03-4 CP-100829 2 2.5E+01 1.2E+01 NA NA 0 NA 760 no 107-88-0 1,3-Butanediol 2 2.5E+01 1.3E+01 NA NA 0.0001 440 761 yes 361343-19-3 Elzasonan 3 3.8E+01 1.3E+01 NA NA 0 NA 762 no 51-79-6 Urethane 2 2.5E+01 1.3E+01 NA NA 0.00138 400 763 no 24851-98-7 Methyl dihydrojasmonate 2 2.5E+01 1.3E+01 NA NA 0 NA 764 no 52806-53-8 Hydroxyflutamide 2 2.5E+01 1.3E+01 inactive NA 0 NA 765 no 1671-75-6 Heptanophenone 3 3.8E+01 1.3E+01 NA NA 0.00686 313 766 no 107071-66-9 Ro 23-7637 2 2.5E+01 1.3E+01 NA NA NA NA 767 no 106-93-4 1,2-Dibromoethane 2 2.6E+01 1.3E+01 NA NA 0.000074 448 768 yes 66441-23-4 Fenoxaprop-ethyl 2 2.6E+01 1.3E+01 NA NA 0 NA 769 yes 102-76-1 Triacetin 3 3.8E+01 1.3E+01 NA NA 0.0182 217 770 no 122-78-1 Phenylacetaldehyde 2 2.6E+01 1.3E+01 NA NA 0.0042 347 771 no 19780-11-1 (2-Dodecenyl)succinic anhydride 2 2.6E+01 1.3E+01 NA NA 0 NA 772 no 633-96-5 C.I. Acid Orange 7 2 2.6E+01 1.3E+01 NA NA 0 NA 773 no 10222-01-2 2,2-Dibromo-3-nitrilopropionamide 2 2.6E+01 1.3E+01 NA NA 0 NA 774 yes 3026-63-9 Sodium tridecyl sulfate 3 4.0E+01 1.3E+01 NA NA 0 NA 775 no 60-12-8 2-Phenylethanol 1 1.3E+01 1.3E+01 NA NA 0 NA 776 yes 101-37-1 2,4,6-Tris(allyloxy)-1,3,5-triazine 2 2.6E+01 1.3E+01 NA NA 0 NA 777 no 42509-80-8 Isazofos 2 2.7E+01 1.3E+01 NA NA 0.00007 452 778 yes 24549-06-2 2-Ethyl-6-methylaniline 3 4.0E+01 1.3E+01 NA NA 0.00519 331 779 no 3855-32-1 2,6,10-Trimethyl-2,6,10- 2 2.7E+01 1.3E+01 NA NA 0.00669 315 780 triazaundecane no 101-83-7 Dicyclohexylamine 2 2.7E+01 1.4E+01 NA NA 0 NA 781 no 23089-26-1 Levomenol 1 1.4E+01 1.4E+01 NA NA 0 NA 782 no 95-65-8 3,4-Dimethylphenol 3 4.1E+01 1.4E+01 NA NA 0 NA 783 no 98-52-2 4-tert-Butylcyclohexanol 2 2.7E+01 1.4E+01 NA NA 0 NA 784 no 92-87-5 Benzidine 3 4.1E+01 1.4E+01 NA NA 0.0183 216 785 no 56-72-4 Coumaphos 1 1.4E+01 1.4E+01 NA NA 0 NA 786 yes 101-86-0 2-Benzylideneoctanal 3 4.2E+01 1.4E+01 NA NA 0.00983 273 787 no 121-75-5 Malathion 2 2.8E+01 1.4E+01 NA NA NA NA 788 yes 38

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 51707-55-2 Thidiazuron 2 2.8E+01 1.4E+01 NA NA 0 NA 789 yes 110-85-0 Piperazine 2 2.8E+01 1.4E+01 NA NA 0 NA 790 no 4455-26-9 N-Methyldioctylamine 2 2.8E+01 1.4E+01 NA NA 0.00011 435 791 no 110-42-9 Methyl decanoate 1 1.4E+01 1.4E+01 NA NA 0 NA 792 no 27253-33-4 Calcium neodecanoate 2 2.8E+01 1.4E+01 NA NA 0.00011 436 793 no 55406-53-6 3-Iodo-2-propynyl-N- 2 2.8E+01 1.4E+01 NA NA 0 NA 794 butylcarbamate yes 111-70-6 1-Heptanol 2 2.8E+01 1.4E+01 NA NA 0 NA 795 no 123-31-9 Hydroquinone 2 2.9E+01 1.4E+01 NA NA 0 NA 796 no 111991-09-4 Nicosulfuron 2 2.9E+01 1.4E+01 NA NA 0 NA 797 yes 1120-01-0 Sodium hexyldecyl sulfate 1 1.4E+01 1.4E+01 NA NA 0 NA 798 no 120-51-4 Benzyl benzoate 3 4.3E+01 1.4E+01 NA NA 0 NA 799 yes 108-98-5 Benzenethiol 3 4.4E+01 1.5E+01 NA NA 0.00908 284 800 no 78-51-3 Tris(2-butoxyethyl) phosphate 1 1.5E+01 1.5E+01 NA NA 0.00012 430 801 no 99-97-8 N,N,4-Trimethylaniline 3 4.4E+01 1.5E+01 NA NA 0.00737 308 802 no 112-18-5 N,N-Dimethyldodecan-1-amine 3 4.4E+01 1.5E+01 NA NA 0 NA 803 no 587-65-5 2-Chloro-N-phenylacetamide 2 2.9E+01 1.5E+01 NA NA 0 NA 804 no 8000-34-8 Clove leaf oil 1 1.5E+01 1.5E+01 NA NA 0.000055 463 805 no 938-16-9 tert-Butyl phenyl ketone 3 4.4E+01 1.5E+01 NA NA 0 NA 806 no 8006-90-4 Peppermint oil 2 3.0E+01 1.5E+01 NA NA 0.00851 289 807 no NOCAS_47311 GSK163929B 2 3.0E+01 1.5E+01 NA NA NA NA 808 no 5598-13-0 Chlorpyrifos-methyl 2 3.0E+01 1.5E+01 NA NA 0.000064 454 809 yes 106-22-9 Citronellol 2 3.0E+01 1.5E+01 NA NA 0 NA 810 yes NOCAS_48518 PharmaGSID_48518 2 3.1E+01 1.5E+01 NA NA NA NA 811 no 1061517-62-1 PharmaGSID_47337 1 1.5E+01 1.5E+01 NA NA 0 NA 812 no 2425-06-1 Captafol 2 3.1E+01 1.5E+01 NA NA 0 NA 813 no 123-77-3 Azodicarbonamide 1 1.6E+01 1.6E+01 NA NA 0 NA 814 no 1948-33-0 tert-Butylhydroquinone 2 3.2E+01 1.6E+01 NA NA 0.00291 370 815 no 1861-32-1 Chlorthal-dimethyl 3 4.9E+01 1.6E+01 NA NA 0 NA 816 yes 93-08-3 2'-Acetonaphthone 2 3.3E+01 1.6E+01 NA NA 0.00257 375 817 no 298-07-7 Bis(2-ethylhexyl) phosphate 1 1.6E+01 1.6E+01 NA NA 0 NA 818 no 20265-97-8 4-Methoxyaniline hydrochloride 1 1.6E+01 1.6E+01 NA NA 0 NA 819 no 39

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 199119-58-9 Trifloxysulfuron-sodium 2 3.3E+01 1.7E+01 NA NA 0.00375 353 820 no 328-84-7 1,2-Dichloro-4- 1 1.7E+01 1.7E+01 NA NA 0 NA 821 (trifluoromethyl)benzene no 95-13-6 Indene 3 5.0E+01 1.7E+01 NA NA 0.0117 263 822 no 1569-02-4 1-Ethoxy-2-propanol 2 3.4E+01 1.7E+01 NA NA 0.00072 406 823 no 133-06-2 Captan 2 3.4E+01 1.7E+01 NA NA 0 NA 824 yes 446-86-6 Azathioprine 2 3.4E+01 1.7E+01 NA NA 0 NA 825 no 3380-34-5 Triclosan 2 3.5E+01 1.7E+01 NA NA 0 NA 826 yes 118-55-8 Phenyl salicylate 2 3.5E+01 1.7E+01 NA NA 0 NA 827 no 139340-56-0 Darbufelone mesylate 2 3.5E+01 1.7E+01 NA NA 0 NA 828 no 98-07-7 Benzotrichloride 3 5.2E+01 1.7E+01 NA NA 0 NA 829 no 89-83-8 Thymol 2 3.5E+01 1.7E+01 NA NA 0.00465 339 830 yes 534-52-1 2-Methyl-4,6-dinitrophenol 2 3.5E+01 1.8E+01 NA NA 0 NA 831 yes 52225-20-4 dl-alpha-Tocopheryl acetate 1 1.8E+01 1.8E+01 NA NA 0 NA 832 no 1120-71-4 1,3-Propane sultone 1 1.8E+01 1.8E+01 NA NA 0 NA 833 no 7487-94-7 Mercuric chloride 2 3.6E+01 1.8E+01 NA NA 0 NA 834 yes 36734-19-7 Iprodione 1 1.8E+01 1.8E+01 NA NA 0 NA 835 yes 60-54-8 Tetracycline 2 3.6E+01 1.8E+01 NA NA 0 NA 836 no 221246-12-4 Fandosentan potassium salt 2 3.6E+01 1.8E+01 NA NA 0 NA 837 no 123-07-9 4-Ethylphenol 3 5.4E+01 1.8E+01 NA NA 0.00352 358 838 no 126-72-7 Tris(2,3-dibromopropyl) phosphate 2 3.6E+01 1.8E+01 NA NA 0 NA 839 no 81777-89-1 Clomazone 2 3.7E+01 1.8E+01 NA NA 0 NA 840 yes 110235-47-7 Mepanipyrim 1 1.8E+01 1.8E+01 NA NA 0.000078 446 841 no 142-16-5 Bis(2-ethylhexyl) maleate 1 1.8E+01 1.8E+01 NA NA 0 NA 842 no 83657-24-3 Diniconazole 3 5.5E+01 1.8E+01 NA NA 0 NA 843 no 5902-51-2 Terbacil 1 1.9E+01 1.9E+01 NA NA 0 NA 844 yes 19774-82-4 Amiodarone hydrochloride 1 1.9E+01 1.9E+01 NA NA 0 NA 845 no 526-75-0 2,3-Dimethylphenol 2 3.7E+01 1.9E+01 NA NA 0 NA 846 no 57-10-3 Hexadecanoic acid 2 3.8E+01 1.9E+01 NA NA 0.00386 352 847 no 4376-20-9 Mono(2-ethylhexyl) phthalate 2 3.8E+01 1.9E+01 NA NA 0 NA 848 no 2492-26-4 Sodium 2-mercaptobenzothiolate 1 1.9E+01 1.9E+01 NA NA 0 NA 849 yes 76738-62-0 Paclobutrazol 1 1.9E+01 1.9E+01 NA NA 0 NA 850 yes 40

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 112-30-1 1-Decanol 1 1.9E+01 1.9E+01 NA NA 0 NA 851 yes 83-41-0 1,2-Dimethyl-3-nitrobenzene 2 3.9E+01 1.9E+01 NA NA 0 NA 852 no 3844-45-9 FD&C Blue No. 1 1 1.9E+01 1.9E+01 NA NA 0 NA 853 yes 102-06-7 1,3-Diphenylguanidine 1 1.9E+01 1.9E+01 NA NA 0 NA 854 no 86-50-0 Azinphos-methyl 2 3.9E+01 2.0E+01 NA NA 0 NA 855 yes 87-68-3 Hexachloro-1,3-butadiene 1 2.0E+01 2.0E+01 NA NA 0 NA 856 no 439687-69-1 Nelivaptan 2 4.0E+01 2.0E+01 NA NA 0 NA 857 no 21725-46-2 Cyanazine 1 2.0E+01 2.0E+01 NA NA 0 NA 858 yes 119-36-8 Methyl salicylate 1 2.0E+01 2.0E+01 NA NA 0 NA 859 yes 1929-77-7 Vernolate 1 2.0E+01 2.0E+01 NA NA 0 NA 860 yes 22915-73-7 Hexane-1,6-diyl dibenzoate 2 4.0E+01 2.0E+01 NA NA 0.00322 363 861 no 149413-74-1 FR150011 1 2.0E+01 2.0E+01 NA NA NA NA 862 no 2465-27-2 Auramine hydrochloride 2 4.1E+01 2.0E+01 NA NA 0 NA 863 no 132-64-9 Dibenzofuran 3 6.1E+01 2.0E+01 NA NA 0.00597 321 864 no 3452-97-9 3,5,5-Trimethyl-1-hexanol 2 4.1E+01 2.0E+01 NA NA 0 NA 865 no 818-61-1 2-Hydroxyethyl acrylate 2 4.1E+01 2.1E+01 NA NA 0 NA 866 no 108-83-8 Diisobutyl ketone 2 4.1E+01 2.1E+01 NA NA 0 NA 867 yes 128-37-0 Butylated hydroxytoluene 1 2.1E+01 2.1E+01 NA NA 0 NA 868 yes 110-73-6 2-(Ethylamino)ethanol 2 4.2E+01 2.1E+01 NA NA 0 NA 869 no 28434-00-6 S-Bioallethrin 2 4.3E+01 2.2E+01 NA NA 0 NA 870 yes 23184-66-9 Butachlor 2 4.4E+01 2.2E+01 NA NA 0 NA 871 no 75-12-7 Formamide 1 2.2E+01 2.2E+01 NA NA NA NA 872 no 4468-42-2 3-Phenylhexane 2 4.4E+01 2.2E+01 NA NA 0 NA 873 no 33703-08-1 Hexanedioic acid, diisononyl ester 1 2.2E+01 2.2E+01 NA NA 0 NA 874 no 127-19-5 N,N-Dimethylacetamide 1 2.2E+01 2.2E+01 NA NA 0 NA 875 no 88-06-2 2,4,6-Trichlorophenol 3 6.7E+01 2.2E+01 NA NA 0 NA 876 yes 2694-54-4 Triprop-2-en-1-yl benzene-1,2,4- 1 2.3E+01 2.3E+01 NA NA 0 NA 877 tricarboxylate no 32809-16-8 Procymidone 1 2.3E+01 2.3E+01 inactive NA 0 NA 878 no 68555-86-2 Acid Orange 156 1 2.3E+01 2.3E+01 NA NA 0 NA 879 no 60-56-0 Methimazole 1 2.3E+01 2.3E+01 NA NA 0 NA 880 no 107-41-5 2-Methyl-2,4-pentanediol 1 2.3E+01 2.3E+01 NA NA 0 NA 881 yes 41

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 87-86-5 Pentachlorophenol 1 2.3E+01 2.3E+01 NA NA 0 NA 882 yes 291305-06-1 UK-373911 2 4.6E+01 2.3E+01 NA NA 0 NA 883 no 197077-55-7 UK-333747 1 2.3E+01 2.3E+01 NA NA 0 NA 884 no 94-09-7 Benzocaine 2 4.7E+01 2.3E+01 NA NA 0 NA 885 yes 113-48-4 MGK-264 2 4.7E+01 2.3E+01 NA NA 0 NA 886 yes 1323-38-2 Glyceryl monoricinoleate 2 4.8E+01 2.4E+01 NA NA 0 NA 887 no 54-11-5 Nicotine 2 4.8E+01 2.4E+01 NA NA 0 NA 888 yes 6610-29-3 N-Methylhydrazinecarbothioamide 1 2.4E+01 2.4E+01 NA NA 0 NA 889 no 15307-79-6 Diclofenac sodium 2 4.8E+01 2.4E+01 NA NA 0 NA 890 no 89-72-5 2-(Butan-2-yl)phenol 2 4.8E+01 2.4E+01 NA NA 0 NA 891 no 85507-79-5 Phthalic acid, diundecyl ester, 1 2.4E+01 2.4E+01 NA NA 0 NA 892 branched and linear no NOCAS_47330 PharmaGSID_47330 2 4.9E+01 2.4E+01 NA NA NA NA 893 no 2756-56-1 Isobornyl propanoate 1 2.5E+01 2.5E+01 NA NA 0 NA 894 no NOCAS_47267 CP-642931 1 2.5E+01 2.5E+01 NA NA NA NA 895 no 571-58-4 1,4-Dimethylnaphthalene 1 2.5E+01 2.5E+01 NA NA 0 NA 896 yes 67786-14-5 Acid Red 337 1 2.6E+01 2.6E+01 NA NA 0 NA 897 no 113136-77-9 Cyclanilide 1 2.6E+01 2.6E+01 NA NA 0 NA 898 yes 106-23-0 Citronellal 1 2.6E+01 2.6E+01 NA NA 0 NA 899 no 929601-09-2 SR58611 1 2.6E+01 2.6E+01 NA NA 0 NA 900 no 58846-77-8 Decyl beta-D-glucopyranoside 1 2.6E+01 2.6E+01 NA NA 0.00012 431 901 no 51-21-8 5-Fluorouracil 2 5.2E+01 2.6E+01 NA NA 0 NA 902 no 141-66-2 Dicrotophos 1 2.6E+01 2.6E+01 NA NA 0.00008 445 903 yes 553-26-4 4,4'-Bipyridine 1 2.6E+01 2.6E+01 NA NA 0 NA 904 no 220860-50-4 CP-457920 1 2.6E+01 2.6E+01 NA NA 0 NA 905 no 6190-65-4 Deethylatrazine 1 2.6E+01 2.6E+01 NA NA 0 NA 906 no 51-28-5 2,4-Dinitrophenol 2 5.3E+01 2.6E+01 NA NA 0 NA 907 yes 298-46-4 Carbamazepine 2 5.3E+01 2.7E+01 NA NA 0 NA 908 no 100-97-0 Methenamine 1 2.7E+01 2.7E+01 NA NA 0 NA 909 no 103-41-3 Benzyl cinnamate 1 2.7E+01 2.7E+01 NA NA 0 NA 910 no 349495-42-7 PharmaGSID_47263 1 2.7E+01 2.7E+01 NA NA 0 NA 911 no 499-75-2 Isopropyl-o-cresol 2 5.4E+01 2.7E+01 NA NA 0 NA 912 no 42

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 149-30-4 2-Mercaptobenzothiazole 2 5.5E+01 2.7E+01 NA NA 0 NA 913 yes 13311-84-7 Flutamide 2 5.5E+01 2.7E+01 inactive NA 0 NA 914 no 23135-22-0 Oxamyl 1 2.8E+01 2.8E+01 NA NA 0 NA 915 yes 149877-41-8 Bifenazate 2 5.6E+01 2.8E+01 NA NA 0 NA 916 yes 80-08-0 Dapsone 2 5.6E+01 2.8E+01 NA NA 0.00158 396 917 no 950-37-8 Methidathion 1 2.8E+01 2.8E+01 NA NA 0 NA 918 yes 717-74-8 1,3,5-Triisopropylbenzene 2 5.7E+01 2.8E+01 NA NA 0 NA 919 no 119-90-4 3,3'-Dimethoxybenzidine 1 2.8E+01 2.8E+01 NA NA 0 NA 920 no 55512-33-9 Pyridate 1 2.8E+01 2.8E+01 NA NA 0 NA 921 no 50892-23-4 Pirinixic acid 1 2.8E+01 2.8E+01 NA NA 0 NA 922 no 99-96-7 4-Hydroxybenzoic acid 2 5.7E+01 2.9E+01 NA NA NA NA 923 no 27344-41-8 Disodium 4,4'-bis(2- 3 8.6E+01 2.9E+01 NA NA 0.00215 383 924 sulfostyryl)biphenyl no 2687-96-9 1-Dodecyl-2-pyrrolidinone 1 2.9E+01 2.9E+01 NA NA 0 NA 925 no 28249-77-6 Thiobencarb 1 2.9E+01 2.9E+01 NA NA 0 NA 926 yes NOCAS_47389 SAR150640 2 5.9E+01 2.9E+01 NA NA NA NA 927 no 98886-44-3 Fosthiazate 1 3.0E+01 3.0E+01 NA NA NA NA 928 yes 1490-04-6 Menthol 1 3.0E+01 3.0E+01 NA NA 0 NA 929 yes 22781-23-3 Bendiocarb 1 3.0E+01 3.0E+01 NA NA 0 NA 930 yes 112-70-9 1-Tridecanol 2 6.0E+01 3.0E+01 NA NA 0.00481 337 931 no 23031-36-9 Prallethrin 2 6.0E+01 3.0E+01 NA NA 0 NA 932 yes 533-74-4 Dazomet 1 3.0E+01 3.0E+01 NA NA 0 NA 933 yes 576-26-1 2,6-Dimethylphenol 1 3.0E+01 3.0E+01 NA NA 0 NA 934 no 682-01-9 Tetrapropyl orthosilicate 1 3.0E+01 3.0E+01 NA NA 0 NA 935 no 107534-96-3 Tebuconazole 1 3.0E+01 3.0E+01 NA NA 0 NA 936 yes 594-20-7 2,2-Dichloropropane 2 6.1E+01 3.0E+01 NA NA 0 NA 937 no 105-99-7 Dibutyl hexanedioate 1 3.0E+01 3.0E+01 NA NA 0 NA 938 no 105-53-3 Diethyl propanedioate 2 6.1E+01 3.0E+01 NA NA 0.00416 348 939 no NOCAS_48514 PharmaGSID_48514 2 6.1E+01 3.1E+01 NA NA NA NA 940 no 123312-89-0 Pymetrozine 1 3.1E+01 3.1E+01 NA NA 0 NA 941 yes 105-60-2 Caprolactam 1 3.1E+01 3.1E+01 NA NA 0 NA 942 no 72178-02-0 Fomesafen 1 3.1E+01 3.1E+01 NA NA 0 NA 943 yes 43

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 15310-01-7 Benodanil 1 3.1E+01 3.1E+01 NA NA 0 NA 944 no 5877-42-9 4-Ethyloct-1-yn-3-ol 1 3.1E+01 3.1E+01 NA NA NA NA 945 no 29385-43-1 Tolyltriazole 1 3.2E+01 3.2E+01 NA NA 0 NA 946 no 98-53-3 4-tert-Butylcyclohexanone 1 3.2E+01 3.2E+01 NA NA 0 NA 947 no 13684-56-5 Desmedipham 1 3.3E+01 3.3E+01 NA NA 0.0001 442 948 yes 289716-94-5 CP-607366 2 6.5E+01 3.3E+01 NA NA 0 NA 949 no NOCAS_48522 HMR1171 trifluoroacetate (1:1) 1 3.3E+01 3.3E+01 NA NA NA NA 950 no 478263-98-8 AVE3295 1 3.3E+01 3.3E+01 NA NA 0 NA 951 no 1156-19-0 Tolazamide 1 3.3E+01 3.3E+01 NA NA 0.000017 473 952 no 420-04-2 Cyanamide 1 3.3E+01 3.3E+01 NA NA 0 NA 953 yes 112-80-1 Oleic acid 1 3.3E+01 3.3E+01 NA NA 0 NA 954 yes 65-85-0 Benzoic acid 1 3.4E+01 3.4E+01 NA NA 0 NA 955 yes 283594-90-1 Spiromesifen 1 3.4E+01 3.4E+01 NA NA 0 NA 956 no 106-24-1 Geraniol 2 6.8E+01 3.4E+01 NA NA 0 NA 957 yes 87674-68-8 Dimethenamid 1 3.4E+01 3.4E+01 NA NA 0 NA 958 yes 6385-62-2 Diquat dibromide monohydrate 1 3.4E+01 3.4E+01 NA NA NA NA 959 no 2303-17-5 Tri-allate 1 3.4E+01 3.4E+01 NA NA 0 NA 960 yes 2610-11-9 C.I. Direct Red 81 disodium salt 1 3.5E+01 3.5E+01 NA NA 0 NA 961 no 112-31-2 Decanal 1 3.5E+01 3.5E+01 NA NA 0 NA 962 no 2058-46-0 Oxytetracycline hydrochloride 2 7.0E+01 3.5E+01 NA NA 0 NA 963 yes 136-60-7 Butyl benzoate 1 3.5E+01 3.5E+01 NA NA 0 NA 964 no 1742-14-9 1,1-Bis(3,4-dimethylphenyl)ethane 1 3.5E+01 3.5E+01 NA NA 0 NA 965 no 71283-80-2 Fenoxaprop-P-ethyl 1 3.6E+01 3.6E+01 NA NA 0 NA 966 yes 97-77-8 Disulfiram 2 7.2E+01 3.6E+01 NA NA 0 NA 967 no 100-01-6 4-Nitroaniline 1 3.6E+01 3.6E+01 NA NA 0 NA 968 no 104-45-0 4-Propylanisole 1 3.6E+01 3.6E+01 NA NA 0 NA 969 no 54-85-3 Isoniazid 2 7.3E+01 3.6E+01 NA NA 0 NA 970 no 112-12-9 2-Undecanone 2 7.3E+01 3.6E+01 NA NA 0.00139 399 971 yes 94-80-4 2,4-D 1-butyl ester 1 3.7E+01 3.7E+01 NA NA 0 NA 972 yes 108-77-0 2,4,6-Trichloro-s-triazine 2 7.4E+01 3.7E+01 NA NA 0.00306 368 973 no 7785-26-4 (-)-alpha-Pinene 2 7.4E+01 3.7E+01 NA NA 0 NA 974 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 27178-16-1 Diisodecyl hexanedioate 1 3.7E+01 3.7E+01 NA NA 0 NA 975 no 87392-12-9 S-Metolachlor 1 3.8E+01 3.8E+01 NA NA 0 NA 976 yes 66215-27-8 Cyromazine 1 3.8E+01 3.8E+01 NA NA 0 NA 977 yes 1320-07-6 C.I. Acid Orange 24, monosodium 2 7.6E+01 3.8E+01 NA NA 0 NA 978 salt no 134605-64-4 Butafenacil 1 3.8E+01 3.8E+01 NA NA 0 NA 979 no 100-21-0 Terephthalic acid 1 3.8E+01 3.8E+01 NA NA 0 NA 980 no 110-33-8 Dihexyl hexanedioate 1 3.8E+01 3.8E+01 NA NA 0 NA 981 no 1191914-21-2 PharmaGSID_48521 2 7.7E+01 3.8E+01 NA NA NA NA 982 no 95-83-0 4-Chloro-1,2-diaminobenzene 1 3.9E+01 3.9E+01 NA NA 0 NA 983 no 98-56-6 1-Chloro-4-(trifluoromethyl)benzene 1 3.9E+01 3.9E+01 NA NA NA NA 984 no NOCAS_48172 PharmaGSID_48172 1 3.9E+01 3.9E+01 NA NA NA NA 985 no 87-24-1 Ethyl 2-methylbenzoate 1 4.0E+01 4.0E+01 NA NA 0 NA 986 no 123-42-2 Diacetone alcohol 1 4.0E+01 4.0E+01 NA NA 0 NA 987 yes 22224-92-6 Fenamiphos 1 4.0E+01 4.0E+01 NA NA 0 NA 988 yes 134-62-3 DEET 1 4.0E+01 4.0E+01 NA NA 0 NA 989 yes 2176-62-7 Pentachloropyridine 1 4.0E+01 4.0E+01 NA NA NA NA 990 no 620-17-7 3-Ethylphenol 1 4.1E+01 4.1E+01 NA NA 0 NA 991 no 121-33-5 4-Hydroxy-3-methoxybenzaldehyde 1 4.1E+01 4.1E+01 NA NA 0 NA 992 no 131-70-4 Monobutyl phthalate 1 4.1E+01 4.1E+01 NA NA 0 NA 993 no 58-08-2 Caffeine 1 4.1E+01 4.1E+01 NA NA 0 NA 994 no 67564-91-4 (2R,6S)-Fenpropimorph 1 4.1E+01 4.1E+01 NA NA 0 NA 995 no 61-82-5 Amitrole 1 4.2E+01 4.2E+01 NA NA 0 NA 996 yes 85-01-8 Phenanthrene 1 4.3E+01 4.3E+01 NA NA 0 NA 997 no 480-63-7 2,4,6-Trimethylbenzoic acid 2 8.5E+01 4.3E+01 NA NA 0 NA 998 no 112410-23-8 Tebufenozide 1 4.3E+01 4.3E+01 NA NA 0 NA 999 yes 34256-82-1 Acetochlor 1 4.3E+01 4.3E+01 NA NA 0 NA 1000 yes 80-27-3 Terpinyl propionate 2 8.6E+01 4.3E+01 NA NA 0 NA 1001 no 153233-91-1 Etoxazole 1 4.3E+01 4.3E+01 NA NA 0 NA 1002 no 50-81-7 L-Ascorbic acid 1 4.3E+01 4.3E+01 NA NA 0 NA 1003 no 544-76-3 Hexadecane 1 4.4E+01 4.4E+01 NA NA 0 NA 1004 no 97-52-9 2-Methoxy-4-nitroaniline 1 4.4E+01 4.4E+01 NA NA 0 NA 1005 no 45

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 99-66-1 Valproic acid 1 4.4E+01 4.4E+01 NA NA NA NA 1006 no NOCAS_47366 SAR115740 1 4.4E+01 4.4E+01 NA NA NA NA 1007 no 96-76-4 2,4-Di-tert-butylphenol 1 4.5E+01 4.5E+01 NA NA 0 NA 1008 no 5216-25-1 4-Chlorobenzotrichloride 1 4.5E+01 4.5E+01 NA NA 0 NA 1009 no 102-60-3 N,N,N',N'-Tetrakis(2- 1 4.5E+01 4.5E+01 NA NA 0 NA 1010 Hydroxypropyl)ethylenediamine no 461-58-5 Cyanoguanidine 1 4.6E+01 4.6E+01 NA NA 0 NA 1011 no 126-30-7 2,2-Dimethylpropane-1,3-diol 1 4.6E+01 4.6E+01 NA NA 0 NA 1012 no 150-13-0 4-Aminobenzoic acid 1 4.6E+01 4.6E+01 NA NA 0 NA 1013 no 148477-71-8 Spirodiclofen 1 4.6E+01 4.6E+01 NA NA 0 NA 1014 no 2031-67-6 Triethoxymethylsilane 1 4.6E+01 4.6E+01 NA NA 0 NA 1015 no 30399-84-9 Isooctadecanoic acid 1 4.6E+01 4.6E+01 NA NA 0 NA 1016 no 96-18-4 1,2,3-Trichloropropane 1 4.6E+01 4.6E+01 NA NA 0 NA 1017 no 126-73-8 Tributyl phosphate 1 4.6E+01 4.6E+01 NA NA 0 NA 1018 no 186392-65-4 Ingliforib 1 4.6E+01 4.6E+01 NA NA 0 NA 1019 no 57966-95-7 Cymoxanil 1 4.7E+01 4.7E+01 NA NA 0 NA 1020 yes 87-01-4 7-(Dimethylamino)-4- 1 4.7E+01 4.7E+01 NA NA 0 NA 1021 methylcoumarin no 50471-44-8 Vinclozolin 1 4.7E+01 4.7E+01 NA NA 0 NA 1022 yes 112-34-5 2-(2-Butoxyethoxy)ethanol 1 4.8E+01 4.8E+01 NA NA 0 NA 1023 no 110-69-0 Butanal oxime 1 4.8E+01 4.8E+01 NA NA 0 NA 1024 no 90-94-8 Michler's ketone 1 4.8E+01 4.8E+01 NA NA 0 NA 1025 no 109-86-4 2-Methoxyethanol 1 4.8E+01 4.8E+01 NA NA 0 NA 1026 yes 110-15-6 Butanedioic acid 1 4.8E+01 4.8E+01 NA NA 0 NA 1027 no 15972-60-8 Alachlor 1 4.9E+01 4.9E+01 NA NA 0 NA 1028 yes 79538-32-2 Tefluthrin 1 4.9E+01 4.9E+01 NA NA 0 NA 1029 yes 95-14-7 1,2,3-Benzotriazole 1 4.9E+01 4.9E+01 NA NA 0 NA 1030 no 96182-53-5 Tebupirimfos 1 4.9E+01 4.9E+01 NA NA 0 NA 1031 yes 99-93-4 4-Hydroxyacetophenone 1 5.0E+01 5.0E+01 NA NA NA NA 1032 no 110-12-3 5-Methyl-2-hexanone 2 1.0E+02 5.1E+01 NA NA 0 NA 1033 no 10605-21-7 Carbendazim 1 5.1E+01 5.1E+01 NA NA 0 NA 1034 yes 128639-02-1 Carfentrazone-ethyl 1 5.1E+01 5.1E+01 NA NA 0 NA 1035 yes 46

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 77-48-5 1,3-Dibromo-5,5-dimethylhydantoin 1 5.2E+01 5.2E+01 NA NA 0 NA 1036 yes 2943-75-1 Triethoxyoctylsilane 1 5.2E+01 5.2E+01 NA Negative 0 NA 1037 no 17804-35-2 Benomyl 1 5.3E+01 5.3E+01 NA NA 0 NA 1038 yes 709-98-8 Propanil 1 5.3E+01 5.3E+01 NA NA 0 NA 1039 yes NOCAS_47291 CI-1044 1 5.3E+01 5.3E+01 NA NA NA NA 1040 no 824-39-5 Sodium 2-nitrophenolate 1 5.3E+01 5.3E+01 NA NA 0 NA 1041 yes 162706-14-1 UK-156819 1 5.4E+01 5.4E+01 NA NA 0 NA 1042 no 214535-77-0 CP-457677 1 5.4E+01 5.4E+01 NA NA 0 NA 1043 no 629-62-9 Pentadecane 1 5.4E+01 5.4E+01 NA NA 0 NA 1044 no 140-67-0 Estragole 1 5.5E+01 5.5E+01 NA NA 0 NA 1045 yes 112-38-9 10-Undecenoic acid 1 5.5E+01 5.5E+01 NA NA 0 NA 1046 yes 50594-66-6 Acifluorfen 1 5.5E+01 5.5E+01 NA NA 0 NA 1047 no 2702-72-9 2,4-D sodium salt 1 5.6E+01 5.6E+01 NA NA 0 NA 1048 yes 1634-78-2 Malaoxon 1 5.6E+01 5.6E+01 NA NA 0 NA 1049 no 4065-45-6 Sulisobenzone 1 5.6E+01 5.6E+01 NA NA 0 NA 1050 no 64700-56-7 Triclopyr-butotyl 1 5.6E+01 5.6E+01 NA NA 0 NA 1051 yes 120-92-3 Cyclopentanone 1 5.6E+01 5.6E+01 NA NA 0 NA 1052 no 627-18-9 3-Bromo-1-propanol 1 5.7E+01 5.7E+01 NA NA NA NA 1053 no 3268-49-3 3-(Methylthio)propanal 1 5.7E+01 5.7E+01 NA NA 0 NA 1054 no 1459-93-4 Dimethyl isophthalate 1 5.7E+01 5.7E+01 NA NA 0 NA 1055 no 151-21-3 Sodium dodecyl sulfate 1 5.7E+01 5.7E+01 NA NA 0 NA 1056 yes 106-47-8 4-Chloroaniline 1 5.8E+01 5.8E+01 NA NA 0 NA 1057 no 7696-12-0 Tetramethrin 1 5.8E+01 5.8E+01 NA NA 0 NA 1058 yes 957-51-7 Diphenamid 1 5.8E+01 5.8E+01 NA NA 0 NA 1059 yes 148-24-3 8-Hydroxyquinoline 1 5.8E+01 5.8E+01 NA NA 0 NA 1060 no 13674-87-8 Tris(1,3-dichloro-2- 1 5.8E+01 5.8E+01 NA NA 0 NA 1061 propyl)phosphate no 7786-34-7 Mevinphos 1 5.8E+01 5.8E+01 NA NA 0 NA 1062 yes 59-40-5 Sulfaquinoxaline 1 5.8E+01 5.8E+01 NA NA 0 NA 1063 yes 111-27-3 1-Hexanol 1 5.9E+01 5.9E+01 NA NA 0 NA 1064 yes 79-44-7 Dimethylcarbamoyl chloride 1 5.9E+01 5.9E+01 NA NA 0 NA 1065 no 577-11-7 Docusate sodium 1 5.9E+01 5.9E+01 NA NA 0 NA 1066 yes 47

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 79277-27-3 Thifensulfuron-methyl 1 5.9E+01 5.9E+01 NA NA 0 NA 1067 yes 65-23-6 Pyridoxine 1 6.0E+01 6.0E+01 NA NA 0 NA 1068 no 14901-07-6 4-(2,6,6-Trimethyl-cyclohex-1-enyl)- 1 6.1E+01 6.1E+01 NA NA 0 NA 1069 but-3-en-2-one no 128-39-2 2,6-Di-tert-butylphenol 1 6.2E+01 6.2E+01 NA NA 0 NA 1070 no 63612-50-0 Nilutamide 1 6.2E+01 6.2E+01 NA NA 0 NA 1071 no 108-32-7 Propylene carbonate 1 6.2E+01 6.2E+01 NA NA 0 NA 1072 no 88-74-4 2-Nitroaniline 1 6.2E+01 6.2E+01 NA NA 0 NA 1073 no 91-20-3 Naphthalene 1 6.2E+01 6.2E+01 NA NA 0 NA 1074 yes 5234-68-4 Carboxin 1 6.3E+01 6.3E+01 NA NA 0 NA 1075 yes 4904-61-4 1,5,9-Cyclododecatriene 1 6.3E+01 6.3E+01 NA NA 0 NA 1076 no 101463-69-8 Flufenoxuron 1 6.4E+01 6.4E+01 NA NA 0 NA 1077 no 6317-18-6 Methylene bis(thiocyanate) 1 6.4E+01 6.4E+01 NA NA 0 NA 1078 yes 99-65-0 1,3-Dinitrobenzene 1 6.4E+01 6.4E+01 NA NA NA NA 1079 no 66357-35-5 Ranitidine 1 6.4E+01 6.4E+01 NA NA 0 NA 1080 no 19044-88-3 Oryzalin 1 6.4E+01 6.4E+01 NA NA 0 NA 1081 yes 2687-25-4 2,3-Diaminotoluene 1 6.5E+01 6.5E+01 NA NA 0 NA 1082 no 10094-34-5 1,1-Dimethyl-2-phenylethyl 1 6.6E+01 6.6E+01 NA NA 0 NA 1083 butanoate no 82469-79-2 Butyryl trihexyl citrate 1 6.6E+01 6.6E+01 NA NA 0 NA 1084 no 1563-66-2 Carbofuran 1 6.6E+01 6.6E+01 NA NA 0 NA 1085 yes 149062-75-9 PharmaGSID_47259 1 6.7E+01 6.7E+01 NA NA 0 NA 1086 no 4418-26-2 Sodium dehydroacetate 1 6.7E+01 6.7E+01 NA NA 0 NA 1087 yes 109-46-6 N,N'-Dibutylthiourea 1 6.8E+01 6.8E+01 NA NA 0 NA 1088 no 68917-18-0 Cornmint oil 1 6.8E+01 6.8E+01 NA NA 0 NA 1089 no 110-62-3 Pentanal 1 6.8E+01 6.8E+01 NA NA 0 NA 1090 no 81-88-9 Rhodamine B 1 6.8E+01 6.8E+01 NA NA 0 NA 1091 no 6285-05-8 Ethyl 4-chlorophenyl ketone 1 6.8E+01 6.8E+01 NA NA 0 NA 1092 no 103-24-2 Bis(2-ethylhexyl) nonanedioate 1 6.9E+01 6.9E+01 NA NA 0 NA 1093 no 124495-18-7 Quinoxyfen 1 6.9E+01 6.9E+01 NA NA 0 NA 1094 yes 140-95-4 Dimethylolurea 1 6.9E+01 6.9E+01 NA NA 0 NA 1095 no 85-40-5 1,2,3,6-Tetrahydrophthalimide 1 6.9E+01 6.9E+01 NA NA 0 NA 1096 no 48

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 94-71-3 2-Ethoxyphenol 1 7.0E+01 7.0E+01 NA NA 0 NA 1097 no 59-30-3 Folic acid 1 7.1E+01 7.1E+01 NA NA 0 NA 1098 no 1321-74-0 Divinylbenzene 1 7.1E+01 7.1E+01 NA NA 0 NA 1099 no 68169-03-9 2- 1 7.1E+01 7.1E+01 NA NA 0 NA 1100 (Dihydrocyclopentadienyloxy)ethyl methacrylate no 29122-68-7 Atenolol 1 7.1E+01 7.1E+01 NA NA 0 NA 1101 no 584-84-9 Toluene-2,4-diisocyanate 1 7.2E+01 7.2E+01 NA NA 0 NA 1102 no 111-49-9 Hexamethyleneimine 1 7.2E+01 7.2E+01 NA NA 0 NA 1103 no 15046-75-0 Sodium 2-methylbenzenesulfonate 1 7.2E+01 7.2E+01 NA NA 0 NA 1104 no 61791-12-6 Cremophor(R) EL 2 1.5E+02 7.3E+01 NA NA 0 NA 1105 no NOCAS_47342 SR125047 1 7.5E+01 7.5E+01 NA NA NA NA 1106 no 4548-53-2 FD&C Red 4 1 7.5E+01 7.5E+01 NA NA 0 NA 1107 no 145742-28-5 CP-122721 1 7.6E+01 7.6E+01 NA NA 0 NA 1108 no 643-79-8 1,2-Benzenedicarboxaldehyde 1 7.7E+01 7.7E+01 NA NA 0 NA 1109 yes 7080-50-4 Chloramine-T trihydrate 1 7.8E+01 7.8E+01 NA NA 0 NA 1110 no 117-84-0 Dioctyl phthalate 1 7.8E+01 7.8E+01 NA NA 0 NA 1111 no 93-99-2 Phenyl benzoate 1 7.9E+01 7.9E+01 NA NA 0 NA 1112 no 528-29-0 1,2-Dinitrobenzene 1 7.9E+01 7.9E+01 NA NA 0 NA 1113 no 460081-99-6 PharmaGSID_48510 1 7.9E+01 7.9E+01 NA NA NA NA 1114 no 107-20-0 Chloroacetaldehyde 1 7.9E+01 7.9E+01 NA NA 0 NA 1115 no 103-33-3 Azobenzene 1 8.1E+01 8.1E+01 NA NA 0 NA 1116 no 35367-38-5 Diflubenzuron 1 8.1E+01 8.1E+01 NA NA 0 NA 1117 yes 23422-53-9 Formetanate hydrochloride 1 8.2E+01 8.2E+01 NA NA 0 NA 1118 yes 3252-43-5 Dibromoacetonitrile 1 8.2E+01 8.2E+01 NA NA NA NA 1119 no 525-79-1 Kinetin 1 8.2E+01 8.2E+01 NA NA 0 NA 1120 yes 828-00-2 Dimethoxane 1 8.3E+01 8.3E+01 NA NA 0 NA 1121 yes 219790-72-4 SB281832 1 8.3E+01 8.3E+01 NA NA 0 NA 1122 no 2122-70-5 Ethyl 1-naphthaleneacetate 1 8.4E+01 8.4E+01 NA NA 0 NA 1123 yes 80-07-9 4,4'-Dichlorodiphenyl sulfone 1 8.4E+01 8.4E+01 NA NA 0 NA 1124 no 118-52-5 1,3-Dichloro-5,5-dimethylhydantoin 1 8.4E+01 8.4E+01 NA NA 0 NA 1125 yes 51-05-8 Procaine hydrochloride 1 8.4E+01 8.4E+01 NA NA 0 NA 1126 no 49

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 1401-55-4 Tannic acid 1 8.5E+01 8.5E+01 NA NA 0 NA 1127 yes 118-82-1 4,4'-Methylenebis(2,6-di-t- 1 8.5E+01 8.5E+01 NA NA 0 NA 1128 butylphenol) no 5329-14-6 Sulfamic acid 1 8.7E+01 8.7E+01 NA NA 0 NA 1129 yes 26896-20-8 Neodecanoic acid 1 8.7E+01 8.7E+01 NA NA 0 NA 1130 no 1646-87-3 Aldicarb sulfoxide 1 8.7E+01 8.7E+01 NA NA 0 NA 1131 no 90-12-0 1-Methylnaphthalene 1 8.8E+01 8.8E+01 NA NA 0 NA 1132 no 626-43-7 3,5-Dichloroaniline 1 8.8E+01 8.8E+01 NA NA 0 NA 1133 no 16423-68-0 FD&C Red 3 1 8.8E+01 8.8E+01 NA NA 0 NA 1134 no 616-45-5 2-Pyrrolidinone 1 8.9E+01 8.9E+01 NA NA 0 NA 1135 no 91-66-7 N,N-Diethylaniline 1 9.0E+01 9.0E+01 NA NA 0 NA 1136 no 263553-33-9 GW473178E methyl benzene 1 9.0E+01 9.0E+01 NA NA 0 NA 1137 sulphonic acid no 4449-51-8 Cyclopamine 1 9.1E+01 9.1E+01 NA NA 0 NA 1138 no 26628-22-8 Sodium azide 1 9.2E+01 9.2E+01 NA NA 0 NA 1139 yes 126-86-3 2,4,7,9-Tetramethyl-5-decyne-4,7- 1 9.2E+01 9.2E+01 NA NA 0 NA 1140 diol no 112-05-0 Nonanoic acid 1 9.5E+01 9.5E+01 NA NA 0 NA 1141 yes 10025-74-8 Dysprosium(III) chloride 1 9.5E+01 9.5E+01 NA NA 0 NA 1142 no 1300-73-8 Dimethylaniline 1 9.5E+01 9.5E+01 NA NA 0 NA 1143 no 103-34-4 4,4'-Dithiodimorpholine 1 9.7E+01 9.7E+01 NA NA 0 NA 1144 no 3871-99-6 PFHS-K 1 9.7E+01 9.7E+01 NA NA 0 NA 1145 no 80-15-9 Cumene hydroperoxide 1 9.7E+01 9.7E+01 NA NA 0 NA 1146 no 7540-51-4 (S)-(-)-beta-Citronellol 1 9.8E+01 9.8E+01 NA NA 0 NA 1147 no 375-85-9 Perfluoroheptanoic acid 1 1.0E+02 1.0E+02 NA NA 0 NA 1148 no 77-89-4 Acetyltriethyl citrate 1 1.0E+02 1.0E+02 NA NA NA NA 1149 no 95-76-1 3,4-Dichloroaniline 1 1.0E+02 1.0E+02 NA NA 0 NA 1150 no 105-67-9 2,4-Dimethylphenol 1 1.0E+02 1.0E+02 NA NA 0 NA 1151 yes 69655-05-6 2',3'-Dideoxyinosine 1 1.1E+02 1.1E+02 NA NA 0 NA 1152 no 78-82-0 2-Methylpropanenitrile 1 1.1E+02 1.1E+02 NA NA 0 NA 1153 no 145-73-3 Endothal 1 1.1E+02 1.1E+02 NA NA 0 NA 1154 yes 116-02-9 3,3,5-Trimethylcyclohexanol 1 1.1E+02 1.1E+02 NA NA 0 NA 1155 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 58-86-6 D-Xylose 1 1.1E+02 1.1E+02 NA NA 0 NA 1156 no 556-61-6 Methyl isothiocyanate 1 1.1E+02 1.1E+02 NA NA 0 NA 1157 yes 261947-38-0 CP-532623 1 1.1E+02 1.1E+02 NA NA 0 NA 1158 no 527-60-6 2,4,6-Trimethylphenol 1 1.1E+02 1.1E+02 NA NA 0 NA 1159 no 111-40-0 Diethylenetriamine 1 1.1E+02 1.1E+02 NA NA 0 NA 1160 no 111-76-2 2-Butoxyethanol 1 1.2E+02 1.2E+02 NA NA 0 NA 1161 yes 88-69-7 2-Isopropylphenol 1 1.2E+02 1.2E+02 NA NA 0 NA 1162 no 103361-09-7 Flumioxazin 1 1.4E+02 1.4E+02 NA NA 0 NA 1163 yes 70568-60-4 4-Butylcyclohexanol 1 1.6E+02 1.6E+02 NA NA 0 NA 1164 no 141-32-2 Butyl acrylate 1 1.6E+02 1.6E+02 NA NA 0 NA 1165 no 1646-75-9 Aldicarb oxime 1 1.9E+02 1.9E+02 NA NA 0 NA 1166 no 25168-05-2 Chlorotoluene 1 2.0E+02 2.0E+02 NA NA 0 NA 1167 no 14233-37-5 1,4-Bis(N- 1 2.5E+02 2.5E+02 NA NA 0 NA 1168 isopropylamino)anthraquinone no 589-68-4 Tetradecanoic acid, 2,3- 1 3.2E+02 3.2E+02 NA NA 0 NA 1169 dihydroxypropyl ester no NOCAS_47292 PD 0200347 0 1.0E+03 #DIV/0! NA NA NA NA 1170 no 129298-91-5 TNP-470 0 1.0E+03 #DIV/0! NA NA NA NA 1171 no 99-99-0 4-Nitrotoluene 0 1.0E+03 #DIV/0! NA NA NA NA 1172 no 99-54-7 3,4-Dichloronitrobenzene 0 1.0E+03 #DIV/0! NA NA NA NA 1173 no NOCAS_47385 SAR377142 0 1.0E+03 #DIV/0! NA NA NA NA 1174 no NOCAS_47299 CP-422935 0 1.0E+03 #DIV/0! NA NA NA NA 1175 no 625114-41-2 Piragliatin 0 1.0E+03 #DIV/0! NA NA NA NA 1176 no NOCAS_47333 PharmaGSID_47333 0 1.0E+03 #DIV/0! NA NA NA NA 1177 no 99-62-7 1,3-Diisopropylbenzene 0 1.0E+03 #DIV/0! NA NA NA NA 1178 no 98-86-2 Acetophenone 0 1.0E+03 #DIV/0! NA NA NA NA 1179 no 99-55-8 2-Methyl-5-nitroaniline 0 1.0E+03 #DIV/0! NA NA NA NA 1180 no 36673-16-2 Isopropyl triethanolamine titanate 0 1.0E+03 #DIV/0! NA NA NA NA 1181 no 2605-79-0 N,N-Dimethyldecylamine oxide 0 1.0E+03 #DIV/0! NA NA NA NA 1182 no 99-63-8 1,3-Benzenedicarbonyl dichloride 0 1.0E+03 #DIV/0! NA NA NA NA 1183 no 99-59-2 2-Methoxy-5-nitroaniline 0 1.0E+03 #DIV/0! NA NA NA NA 1184 no 99607-70-2 Cloquintocet-mexyl 0 1.0E+03 #DIV/0! NA NA NA NA 1185 no 51

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 68515-49-1 1,2-Benzenedicarboxylic acid, di-C9- 0 1.0E+03 #DIV/0! NA NA NA NA 1186 11-branched alkyl esters, C10-rich no 136042-19-8 FR130739 0 1.0E+03 #DIV/0! NA NA NA NA 1187 no 123-51-3 Isopentyl alcohol 0 1.0E+03 #DIV/0! NA NA NA NA 1188 no NOCAS_48516 PharmaGSID_48516 0 1.0E+03 #DIV/0! NA NA NA NA 1189 no 7631-86-9 Silica 0 1.0E+03 #DIV/0! NA NA NA NA 1190 yes NOCAS_47796 Formalin 0 1.0E+03 #DIV/0! NA NA NA NA 1191 no 271-89-6 2,3-Benzofuran 0 1.0E+03 #DIV/0! NA NA NA NA 1192 no 98-87-3 Benzal chloride 0 1.0E+03 #DIV/0! NA NA NA NA 1193 no 473289-62-2 Ilepatril 0 1.0E+03 #DIV/0! NA NA NA NA 1194 no 150-78-7 Hydroquinone dimethyl ether 0 1.0E+03 #DIV/0! NA NA NA NA 1195 no 146011-65-6 FR145237 0 1.0E+03 #DIV/0! NA NA NA NA 1196 no 999-97-3 Hexamethyldisilazane 0 1.0E+03 #DIV/0! NA NA NA NA 1197 no 99-51-4 1,2-Dimethyl-4-nitrobenzene 0 1.0E+03 #DIV/0! NA NA NA NA 1198 no 98-92-0 Niacinamide 0 1.0E+03 #DIV/0! NA NA NA NA 1199 no 99-87-6 p-Cymene 0 1.0E+03 #DIV/0! NA NA NA NA 1200 no 650-51-1 Sodium trichloroacetate 0 1.0E+03 #DIV/0! NA NA NA NA 1201 yes 108-99-6 3-Methylpyridine 0 1.0E+03 #DIV/0! NA NA NA NA 1202 no 64-19-7 Acetic acid 0 1.0E+03 #DIV/0! NA NA NA NA 1203 yes NOCAS_47265 CP-471358 0 1.0E+03 #DIV/0! NA NA NA NA 1204 no NOCAS_47255 CP-465394 0 1.0E+03 #DIV/0! NA NA NA NA 1205 no 138472-01-2 FR900409 0 1.0E+03 #DIV/0! NA NA NA NA 1206 no 124-09-4 1,6-Hexanediamine 0 1.0E+03 #DIV/0! NA NA NA NA 1207 no 532-32-1 Sodium benzoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1208 yes 23779-32-0 1-[3-(Triethoxysilyl)propyl]urea 0 1.0E+03 #DIV/0! NA NA 0 NA 1209 no 692-86-4 Ethyl undec-10-enoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1210 no 2696-84-6 4-Propylaniline 0 1.0E+03 #DIV/0! NA NA 0 NA 1211 no 544-63-8 Tetradecanoic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1212 no 6728-26-3 (2E)-2-Hexenal 0 1.0E+03 #DIV/0! NA NA 0 NA 1213 no 98-06-6 tert-Butylbenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1214 no 2078-54-8 Propofol 0 1.0E+03 #DIV/0! NA NA 0 NA 1215 no 4180-23-8 (E)-Anethole 0 1.0E+03 #DIV/0! NA NA 0 NA 1216 no 52

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 165252-70-0 Dinotefuran 0 1.0E+03 #DIV/0! NA NA 0 NA 1217 no 123-25-1 Diethyl butanedioate 0 1.0E+03 #DIV/0! NA NA 0 NA 1218 no 58394-64-2 Benzyloctyl adipate 0 1.0E+03 #DIV/0! NA NA 0 NA 1219 no 756-79-6 Dimethyl methylphosphonate 0 1.0E+03 #DIV/0! NA NA 0 NA 1220 no 59756-60-4 Fluridone 0 1.0E+03 #DIV/0! NA NA 0 NA 1221 yes 7747-35-5 5-Ethyl-1-aza-3,7- 0 1.0E+03 #DIV/0! NA NA 0 NA 1222 dioxabicyclo[3.3.0]octane yes 919-30-2 3-Aminopropyltriethoxysilane 0 1.0E+03 #DIV/0! NA NA 0 NA 1223 no 55814-41-0 Mepronil 0 1.0E+03 #DIV/0! NA NA 0 NA 1224 no 68515-75-3 Hexanedioic acid, di-C7-9-branched 0 1.0E+03 #DIV/0! NA NA 0 NA 1225 and linear alkyl esters no 21662-09-9 (4Z)-4-Decenal 0 1.0E+03 #DIV/0! NA NA 0 NA 1226 no 614-45-9 tert-Butyl perbenzoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1227 no 78491-02-8 Diazolidinyl urea 0 1.0E+03 #DIV/0! NA NA 0 NA 1228 no 6915-15-7 Malic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1229 yes 6153-64-6 Oxytetracycline dihydrate 0 1.0E+03 #DIV/0! NA NA 0 NA 1230 no 93-56-1 Styrene glycol 0 1.0E+03 #DIV/0! NA NA 0 NA 1231 no 9016-00-6 Polydimethylsiloxane 0 1.0E+03 #DIV/0! NA NA 0 NA 1232 no 1632-73-1 Fenchol 0 1.0E+03 #DIV/0! NA NA 0 NA 1233 no 2528-16-7 Monobenzyl phthalate 0 1.0E+03 #DIV/0! NA NA 0 NA 1234 no 86386-73-4 Fluconazole 0 1.0E+03 #DIV/0! NA NA 0 NA 1235 no 91465-08-6 lambda-Cyhalothrin 0 1.0E+03 #DIV/0! NA NA 0 NA 1236 yes 77-86-1 Tromethamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1237 no 84-66-2 Diethyl phthalate 0 1.0E+03 #DIV/0! NA NA 0 NA 1238 no 628-63-7 Pentyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1239 yes 28631-66-5 C.I. Acid Blue 22 0 1.0E+03 #DIV/0! NA NA 0 NA 1240 no 85532-75-8 PK 11195 0 1.0E+03 #DIV/0! NA NA 0 NA 1241 no 81405-85-8 Imazmethabenz 0 1.0E+03 #DIV/0! NA NA 0 NA 1242 yes 648917-13-9 AVE2865 0 1.0E+03 #DIV/0! NA NA 0 NA 1243 no 51-30-9 Isoproterenol hydrochloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1244 no 770-35-4 1-Phenoxy-2-propanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1245 no 125401-92-5 Bispyribac-sodium 0 1.0E+03 #DIV/0! NA NA 0 NA 1246 yes 53

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 52-51-7 Bronopol 0 1.0E+03 #DIV/0! NA NA 0 NA 1247 yes 6359-98-4 C.I. Acid Yellow 17, disodium salt 0 1.0E+03 #DIV/0! NA NA 0 NA 1248 no 7378-99-6 N,N-Dimethyloctylamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1249 no 862243-29-6 AVE9423 0 1.0E+03 #DIV/0! NA NA 0 NA 1250 no 74115-24-5 Clofentezine 0 1.0E+03 #DIV/0! NA NA 0 NA 1251 yes 156-60-5 (E)-1,2-Dichloroethylene 0 1.0E+03 #DIV/0! NA NA 0 NA 1252 no 7681-76-7 Ronidazole 0 1.0E+03 #DIV/0! NA NA 0 NA 1253 no 121-32-4 3-Ethoxy-4-hydroxybenzaldehyde 0 1.0E+03 #DIV/0! NA NA 0 NA 1254 no 98-51-1 4-tert-Butyltoluene 0 1.0E+03 #DIV/0! NA NA 0 NA 1255 no 55-18-5 N-Nitrosodiethylamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1256 no 16893-85-9 Sodium hexafluorosilicate 0 1.0E+03 #DIV/0! NA NA 0 NA 1257 yes 78-69-3 3,7-Dimethyl-3-octanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1258 no 124378-77-4 Enadoline 0 1.0E+03 #DIV/0! NA NA 0 NA 1259 no 95-54-5 1,2-Phenylenediamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1260 no 75-99-0 Dalapon 0 1.0E+03 #DIV/0! NA NA 0 NA 1261 yes 1934-21-0 FD&C Yellow 5 0 1.0E+03 #DIV/0! NA NA 0 NA 1262 yes 7757-79-1 Potassium nitrate 0 1.0E+03 #DIV/0! NA NA 0 NA 1263 yes 7398-69-8 Dimethyldiallylammonium chloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1264 no 13755-29-8 Sodium tetrafluoroborate 0 1.0E+03 #DIV/0! NA NA 0 NA 1265 no 57-06-7 Allyl isothiocyanate 0 1.0E+03 #DIV/0! NA NA 0 NA 1266 yes 142459-58-3 Flufenacet 0 1.0E+03 #DIV/0! NA NA 0 NA 1267 yes 353280-07-6 CP-612372 0 1.0E+03 #DIV/0! NA NA 0 NA 1268 no 77-90-7 Acetyl tributyl citrate 0 1.0E+03 #DIV/0! NA NA 0 NA 1269 no 57-13-6 Urea 0 1.0E+03 #DIV/0! NA NA 0 NA 1270 yes 87546-18-7 Flumiclorac-pentyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1271 yes 5138-18-1 Sulfosuccinic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1272 no 137-42-8 Metam-sodium 0 1.0E+03 #DIV/0! NA NA 0 NA 1273 yes 230954-09-3 CP-544439 0 1.0E+03 #DIV/0! NA NA 0 NA 1274 no 556-52-5 Glycidol 0 1.0E+03 #DIV/0! NA NA 0 NA 1275 no 75-64-9 tert-Butylamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1276 no 122836-35-5 Sulfentrazone 0 1.0E+03 #DIV/0! NA NA 0 NA 1277 yes

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 24602-86-6 Tridemorph 0 1.0E+03 #DIV/0! NA NA 0 NA 1278 no 125-12-2 Isobornyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1279 yes 1330-86-5 Diisooctyl adipate 0 1.0E+03 #DIV/0! NA NA 0 NA 1280 no 732-11-6 Phosmet 0 1.0E+03 #DIV/0! NA NA 0 NA 1281 yes 97-59-6 Allantoin 0 1.0E+03 #DIV/0! NA NA 0 NA 1282 no 94-96-2 2-Ethyl-1,3-hexanediol 0 1.0E+03 #DIV/0! NA NA 0 NA 1283 yes 5394-36-5 5-Ethyl-5-methylhydantoin 0 1.0E+03 #DIV/0! NA NA 0 NA 1284 no 89-71-4 Methyl 2-methylbenzoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1285 no 96-23-1 1,3-Dichloro-2-propanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1286 no 35575-96-3 Azamethiphos 0 1.0E+03 #DIV/0! NA NA 0 NA 1287 no 2432-87-3 Dioctyl succinate 0 1.0E+03 #DIV/0! NA NA 0 NA 1288 no 147-24-0 Diphenhydramine hydrochloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1289 no 93-89-0 Ethyl benzoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1290 no 94-59-7 Safrole 0 1.0E+03 #DIV/0! NA NA 0 NA 1291 no 83834-59-7 2-Ethylhexyl trans-4- 0 1.0E+03 #DIV/0! NA NA 0 NA 1292 methoxycinnamate no 96-45-7 Ethylene thiourea 0 1.0E+03 #DIV/0! NA NA 0 NA 1293 yes 94-74-6 MCPA 0 1.0E+03 #DIV/0! NA NA 0 NA 1294 yes 30516-87-1 3'-Azido-3'-deoxythymidine 0 1.0E+03 #DIV/0! NA NA 0 NA 1295 no 826-62-0 3a,4,7,7a-Tetrahydro-4,7- 0 1.0E+03 #DIV/0! NA NA 0 NA 1296 methanoisobenzofuran-1,3-dione no 79-57-2 Oxytetracycline 0 1.0E+03 #DIV/0! NA NA 0 NA 1297 no 8018-01-7 Mancozeb 0 1.0E+03 #DIV/0! NA NA 0 NA 1298 yes 2687-94-7 N-Octyl-2-pyrrolidone 0 1.0E+03 #DIV/0! NA NA 0 NA 1299 no 71-23-8 1-Propanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1300 yes 55934-93-5 Tripropylene glycol butyl ether 0 1.0E+03 #DIV/0! NA NA 0 NA 1301 no 6789-88-4 Hexyl benzoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1302 no 851916-42-2 MK-812 0 1.0E+03 #DIV/0! NA NA 0 NA 1303 no 27314-13-2 Norflurazon 0 1.0E+03 #DIV/0! NA NA 0 NA 1304 yes 121-14-2 2,4-Dinitrotoluene 0 1.0E+03 #DIV/0! NA NA 0 NA 1305 no 84087-01-4 Quinclorac 0 1.0E+03 #DIV/0! NA NA 0 NA 1306 yes 41372-08-1 Methyldopa sesquihydrate 0 1.0E+03 #DIV/0! NA NA 0 NA 1307 no 55

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 962-58-3 Diazoxon 0 1.0E+03 #DIV/0! NA NA 0 NA 1308 no 470-82-6 1,8-Cineol 0 1.0E+03 #DIV/0! NA NA 0 NA 1309 no 1120-21-4 Undecane 0 1.0E+03 #DIV/0! NA NA 0 NA 1310 no 599-79-1 Sulfasalazine 0 1.0E+03 #DIV/0! NA NA 0 NA 1311 no 512-42-5 Sodium methyl sulfate 0 1.0E+03 #DIV/0! NA NA 0 NA 1312 no 924-16-3 N-Nitrosodibutylamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1313 no 3194-55-6 1,2,5,6,9,10- 0 1.0E+03 #DIV/0! NA NA 0 NA 1314 Hexabromocyclododecane no 120-72-9 Indole 0 1.0E+03 #DIV/0! NA NA 0 NA 1315 yes 128-04-1 Sodium dimethyldithiocarbamate 0 1.0E+03 #DIV/0! NA NA 0 NA 1316 yes 128-95-0 1,4-Diaminoanthraquinone 0 1.0E+03 #DIV/0! NA NA 0 NA 1317 no 53219-21-9 7-Octen-2-ol, 2-methyl-6- 0 1.0E+03 #DIV/0! NA NA 0 NA 1318 methylene-, dihydro deriv. no 550-44-7 N-Methylphthalimide 0 1.0E+03 #DIV/0! NA NA 0 NA 1319 no 26402-26-6 Glyceryl monooctanoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1320 no 68515-48-0 DINP branched 0 1.0E+03 #DIV/0! NA NA 0 NA 1321 no 77-06-5 Gibberellic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1322 yes 71526-07-3 MON-4660 0 1.0E+03 #DIV/0! NA NA 0 NA 1323 no 79-16-3 N-Methylacetamide 0 1.0E+03 #DIV/0! NA NA 0 NA 1324 no 95-87-4 2,5-Dimethylphenol 0 1.0E+03 #DIV/0! NA NA 0 NA 1325 no 553-70-8 Magnesium dibenzoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1326 no 57-50-1 Sucrose 0 1.0E+03 #DIV/0! NA NA 0 NA 1327 yes 95-49-8 2-Chlorotoluene 0 1.0E+03 #DIV/0! NA NA 0 NA 1328 no 2043-57-4 1H,1H,2H,2H-Perfluorooctyl iodide 0 1.0E+03 #DIV/0! NA NA 0 NA 1329 no 838-85-7 Diphenyl phosphate 0 1.0E+03 #DIV/0! NA NA 0 NA 1330 no 3739-38-6 3-Phenoxybenzoic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1331 no 25265-71-8 Dipropylene glycol 0 1.0E+03 #DIV/0! NA NA 0 NA 1332 yes 78-70-6 Linalool 0 1.0E+03 #DIV/0! NA NA 0 NA 1333 yes 94-28-0 Triethylene glycol bis(2- 0 1.0E+03 #DIV/0! NA NA 0 NA 1334 ethylhexanoate) no 81131-70-6 Pravastatin sodium 0 1.0E+03 #DIV/0! NA NA 0 NA 1335 no 210631-68-8 Topramezone 0 1.0E+03 #DIV/0! NA NA 0 NA 1336 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 629-76-5 1-Pentadecanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1337 no 112-55-0 1-Dodecanethiol 0 1.0E+03 #DIV/0! NA NA 0 NA 1338 no 95-63-6 1,2,4-Trimethylbenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1339 no 33089-61-1 Amitraz 0 1.0E+03 #DIV/0! NA NA 0 NA 1340 yes 57-30-7 Phenobarbital sodium 0 1.0E+03 #DIV/0! inactive NA 0 NA 1341 no 77-78-1 Dimethyl sulfate 0 1.0E+03 #DIV/0! NA NA 0 NA 1342 no 135158-54-2 Acibenzolar-S-methyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1343 yes 134-20-3 Methyl 2-aminobenzoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1344 yes 98319-26-7 Finasteride 0 1.0E+03 #DIV/0! NA NA 0 NA 1345 no 94-60-0 Dimethyl hexahydroterephthalate 0 1.0E+03 #DIV/0! NA NA 0 NA 1346 no 65-45-2 Salicylamide 0 1.0E+03 #DIV/0! NA NA 0 NA 1347 no 527680-56-4 PHA-00568487 0 1.0E+03 #DIV/0! NA NA 0 NA 1348 no 3653-48-3 MCPA-sodium 0 1.0E+03 #DIV/0! NA NA 0 NA 1349 yes 89-04-3 Trioctyl trimellitate 0 1.0E+03 #DIV/0! NA NA 0 NA 1350 no 824-78-2 Sodium 4-nitrophenolate 0 1.0E+03 #DIV/0! NA NA 0 NA 1351 yes 90-04-0 2-Anisidine 0 1.0E+03 #DIV/0! NA NA 0 NA 1352 no 64-86-8 Colchicine 0 1.0E+03 #DIV/0! NA NA 0 NA 1353 no 139149-55-6 SB202235 0 1.0E+03 #DIV/0! NA NA 0 NA 1354 no 28159-98-0 Cybutryne 0 1.0E+03 #DIV/0! NA NA 0 NA 1355 yes 118-47-8 1H-Pyrazole-3-carboxylic acid, 4,5- 0 1.0E+03 #DIV/0! NA NA 0 NA 1356 dihydro-5-oxo-1-(4-sulfophenyl)- no 1912-24-9 Atrazine 0 1.0E+03 #DIV/0! inactive NA 0 NA 1357 yes 3811-04-9 Potassium chlorate 0 1.0E+03 #DIV/0! NA NA 0 NA 1358 no 9003-11-6 Pluronic F-127 0 1.0E+03 #DIV/0! NA NA 0 NA 1359 no 59227-89-3 Laurocapram 0 1.0E+03 #DIV/0! NA NA 0 NA 1360 no 478149-53-0 PHA-00543613 0 1.0E+03 #DIV/0! NA NA 0 NA 1361 no 1300-72-7 Sodium xylenesulfonate 0 1.0E+03 #DIV/0! NA NA 0 NA 1362 yes 119515-38-7 Icaridin 0 1.0E+03 #DIV/0! NA NA 0 NA 1363 yes 298198-52-4 SSR180711 0 1.0E+03 #DIV/0! NA NA 0 NA 1364 no 2164-17-2 Fluometuron 0 1.0E+03 #DIV/0! NA NA 0 NA 1365 yes 87-69-4 L-Tartaric acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1366 no 26644-46-2 Triforine 0 1.0E+03 #DIV/0! NA NA 0 NA 1367 yes 57

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 95-53-4 2-Methylaniline 0 1.0E+03 #DIV/0! NA NA 0 NA 1368 no 1068967-96-3 SAR102608 0 1.0E+03 #DIV/0! NA NA 0 NA 1369 no 87-90-1 Symclosene 0 1.0E+03 #DIV/0! NA NA 0 NA 1370 yes 1111-78-0 Ammonium carbamate 0 1.0E+03 #DIV/0! NA NA 0 NA 1371 no 62-74-8 Sodium fluoroacetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1372 yes 4376-18-5 Monomethyl phthalate 0 1.0E+03 #DIV/0! NA NA 0 NA 1373 no 834-12-8 Ametryn 0 1.0E+03 #DIV/0! NA NA 0 NA 1374 yes 96-24-2 3-Chloro-1,2-propanediol 0 1.0E+03 #DIV/0! NA NA 0 NA 1375 yes 21087-64-9 Metribuzin 0 1.0E+03 #DIV/0! NA NA 0 NA 1376 yes 95-93-2 1,2,4,5-Tetramethylbenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1377 no 91082-17-6 C10-21 sulfonic acids phenyl esters 0 1.0E+03 #DIV/0! NA NA 0 NA 1378 no 95-94-3 1,2,4,5-Tetrachlorobenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1379 no 90-05-1 2-Methoxyphenol 0 1.0E+03 #DIV/0! NA NA 0 NA 1380 no 3926-62-3 Sodium chloroacetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1381 no 120-61-6 Dimethyl terephthalate 0 1.0E+03 #DIV/0! NA NA 0 NA 1382 no 110-80-5 2-Ethoxyethanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1383 no 864283-48-7 GSK232420A 0 1.0E+03 #DIV/0! NA NA 0 NA 1384 no 9005-65-6 Polysorbate 80 0 1.0E+03 #DIV/0! NA NA 0 NA 1385 no 98-00-0 Furfuryl alcohol 0 1.0E+03 #DIV/0! NA NA 0 NA 1386 no 57-41-0 5,5-Diphenylhydantoin 0 1.0E+03 #DIV/0! NA NA 0 NA 1387 no 93-65-2 Mecoprop 0 1.0E+03 #DIV/0! NA NA 0 NA 1388 no 126-98-7 Methacrylonitrile 0 1.0E+03 #DIV/0! NA NA 0 NA 1389 no 1194-65-6 Dichlobenil 0 1.0E+03 #DIV/0! NA NA 0 NA 1390 yes 464-49-3 D-Camphor 0 1.0E+03 #DIV/0! NA NA 0 NA 1391 no 625-55-8 Isopropyl formate 0 1.0E+03 #DIV/0! NA NA 0 NA 1392 no 762-04-9 Diethyl phosphite 0 1.0E+03 #DIV/0! NA NA 0 NA 1393 no 622-97-9 4-Methylstyrene 0 1.0E+03 #DIV/0! NA NA 0 NA 1394 no 7659-86-1 2-Ethylhexyl sulfanylacetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1395 no 542-92-7 1,3-Cyclopentadiene 0 1.0E+03 #DIV/0! NA NA 0 NA 1396 no 15708-41-5 Ethylenediaminetetraacetic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1397 ferric sodium salt no 151-05-3 Dimethylbenzylcarbinyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1398 no 58

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 77-92-9 Citric acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1399 yes 7681-82-5 Sodium iodide 0 1.0E+03 #DIV/0! NA NA 0 NA 1400 no 1873-88-7 1,1,1,3,5,5,5-Heptamethyltrisiloxane 0 1.0E+03 #DIV/0! NA NA 0 NA 1401 no 78-59-1 Isophorone 0 1.0E+03 #DIV/0! NA NA 0 NA 1402 no 79-14-1 Glycolic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1403 yes 6923-22-4 Monocrotophos 0 1.0E+03 #DIV/0! NA NA 0 NA 1404 yes 68359-37-5 Cyfluthrin 0 1.0E+03 #DIV/0! NA NA 0 NA 1405 yes 67747-09-5 Prochloraz 0 1.0E+03 #DIV/0! NA NA 0 NA 1406 no 6734-80-1 Metam-sodium hydrate 0 1.0E+03 #DIV/0! NA NA 0 NA 1407 no 57837-19-1 Metalaxyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1408 yes 51235-04-2 Hexazinone 0 1.0E+03 #DIV/0! NA NA 0 NA 1409 yes 3033-77-0 N,N,N-Trimethyl(oxiran-2- 0 1.0E+03 #DIV/0! NA NA 0 NA 1410 yl)methanaminium chloride no 14765-30-1 2-sec-Butylcyclohexanone 0 1.0E+03 #DIV/0! NA NA 0 NA 1411 no 2385-85-5 Mirex 0 1.0E+03 #DIV/0! NA NA 0 NA 1412 yes 63-42-3 Lactose 0 1.0E+03 #DIV/0! NA NA 0 NA 1413 no 95-48-7 o-Cresol 0 1.0E+03 #DIV/0! NA NA 0 NA 1414 no 29420-49-3 PFBS-K 0 1.0E+03 #DIV/0! NA NA 0 NA 1415 no 15499-27-1 4-Butylchlorobenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1416 no 112-49-2 Triethylene glycol dimethyl ether 0 1.0E+03 #DIV/0! NA NA 0 NA 1417 no 541-73-1 1,3-Dichlorobenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1418 no 208-96-8 Acenaphthylene 0 1.0E+03 #DIV/0! NA NA 0 NA 1419 no 330198-91-9 Fully acetylated glycerol monoester 0 1.0E+03 #DIV/0! NA NA 0 NA 1420 on 12-Hydroxystearic acid (85%); Fully acetylated glycerol monostearate represents (10%) no 657-84-1 Sodium 4-methylbenzenesulfonate 0 1.0E+03 #DIV/0! NA NA 0 NA 1421 no 1569-01-3 1-Propoxy-2-propanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1422 no 97-99-4 Tetrahydrofurfuryl alcohol 0 1.0E+03 #DIV/0! NA NA 0 NA 1423 no 298-00-0 Methyl parathion 0 1.0E+03 #DIV/0! NA NA 0 NA 1424 yes 86-87-3 1-Naphthaleneacetic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1425 yes

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 166412-78-8 Diisononyl cyclohexane-1,2- 0 1.0E+03 #DIV/0! NA NA 0 NA 1426 dicarboxylate no 124-68-5 2-Amino-2-methylpropan-1-ol 0 1.0E+03 #DIV/0! NA NA 0 NA 1427 no 24800-44-0 Tripropylene glycol 0 1.0E+03 #DIV/0! NA NA 0 NA 1428 no 1559-34-8 3,6,9,12-Tetraoxahexadecan-1-ol 0 1.0E+03 #DIV/0! NA NA 0 NA 1429 no 96-41-3 Cyclopentanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1430 no 7011-83-8 2(3H)-Furanone, 5-hexyldihydro-5- 0 1.0E+03 #DIV/0! NA NA 0 NA 1431 methyl- no 58430-94-7 3,5,5-Trimethylhexyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1432 no 56-04-2 6-Methyl-2-thiouracil 0 1.0E+03 #DIV/0! NA NA 0 NA 1433 no 13194-48-4 Ethoprop 0 1.0E+03 #DIV/0! NA NA 0 NA 1434 yes 83-32-9 Acenaphthene 0 1.0E+03 #DIV/0! NA NA 0 NA 1435 no 2445-77-4 2-Methylbutyl isovalerate 0 1.0E+03 #DIV/0! NA NA 0 NA 1436 no 611-20-1 Benzonitrile, 2-hydroxy- 0 1.0E+03 #DIV/0! NA NA 0 NA 1437 no 5700-49-2 1,2-Ethanediamine dihydriodide 0 1.0E+03 #DIV/0! NA NA 0 NA 1438 no 98-01-1 Furfural 0 1.0E+03 #DIV/0! NA NA 0 NA 1439 no 137-66-6 Ascorbyl palmitate 0 1.0E+03 #DIV/0! NA NA 0 NA 1440 no 95-57-8 2-Chlorophenol 0 1.0E+03 #DIV/0! NA NA 0 NA 1441 yes 499-83-2 2,6-Pyridinedicarboxylic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1442 no 112-60-7 Tetraethylene glycol 0 1.0E+03 #DIV/0! NA NA 0 NA 1443 no 3056-17-5 Stavudine 0 1.0E+03 #DIV/0! NA NA 0 NA 1444 no 2426-08-6 Butyl glycidyl ether 0 1.0E+03 #DIV/0! NA NA 0 NA 1445 no 3337-71-1 Asulam 0 1.0E+03 #DIV/0! NA NA 0 NA 1446 yes 6359-82-6 Acid Yellow 11 0 1.0E+03 #DIV/0! NA NA 0 NA 1447 no 80-56-8 alpha-Pinene 0 1.0E+03 #DIV/0! NA NA 0 NA 1448 yes 520-45-6 Dehydroacetic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1449 no 150-68-5 Monuron 0 1.0E+03 #DIV/0! NA NA 0 NA 1450 yes 134002-60-1 CP-085958 0 1.0E+03 #DIV/0! NA NA 0 NA 1451 no 29590-42-9 Isooctyl acrylate 0 1.0E+03 #DIV/0! NA NA 0 NA 1452 no 598-55-0 Methyl carbamate 0 1.0E+03 #DIV/0! NA NA 0 NA 1453 no 6422-86-2 Bis(2-ethylhexyl) terephthalate 0 1.0E+03 #DIV/0! NA NA 0 NA 1454 no 606-20-2 2,6-Dinitrotoluene 0 1.0E+03 #DIV/0! NA NA 0 NA 1455 no 60

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 81334-34-1 Imazapyr 0 1.0E+03 #DIV/0! NA NA 0 NA 1456 yes 1843-05-6 Octabenzone 0 1.0E+03 #DIV/0! NA NA 0 NA 1457 no 142-04-1 Aniline hydrochloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1458 no 533-23-3 2,4-D-ethyl ester 0 1.0E+03 #DIV/0! NA NA 0 NA 1459 no 62-75-9 N-Nitrosodimethylamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1460 no 60-35-5 Acetamide 0 1.0E+03 #DIV/0! NA NA 0 NA 1461 no 69-65-8 D-Mannitol 0 1.0E+03 #DIV/0! NA NA 0 NA 1462 no 3622-84-2 N-Butylbenzenesulfonamide 0 1.0E+03 #DIV/0! NA NA 0 NA 1463 no 125-84-8 Aminoglutethimide 0 1.0E+03 #DIV/0! NA NA 0 NA 1464 no 3547-33-9 2-Hydroxyethyl octyl sulfide 0 1.0E+03 #DIV/0! NA NA 0 NA 1465 yes 94-75-7 2,4-Dichlorophenoxyacetic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1466 yes 9004-96-0 Polyoxyethylene monoleate 0 1.0E+03 #DIV/0! NA NA 0 NA 1467 no 637-07-0 Clofibrate 0 1.0E+03 #DIV/0! NA NA 0 NA 1468 no 753-73-1 Dimethyltin dichloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1469 no 95-80-7 2,4-Diaminotoluene 0 1.0E+03 #DIV/0! NA NA 0 NA 1470 no 2917-73-9 Dibutyl nonanedioate 0 1.0E+03 #DIV/0! NA NA 0 NA 1471 no 860-22-0 C.I. Acid Blue 74 0 1.0E+03 #DIV/0! NA NA 0 NA 1472 no 2634-33-5 1,2-Benzisothiazolin-3-one 0 1.0E+03 #DIV/0! NA NA 0 NA 1473 yes 123343-16-8 Pyrithiobac-sodium 0 1.0E+03 #DIV/0! NA NA 0 NA 1474 yes 29836-26-8 Octyl beta-D-glucopyranoside 0 1.0E+03 #DIV/0! NA NA 0 NA 1475 no 2807-30-9 2-Propoxyethanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1476 no 123-11-5 4-Methoxybenzaldehyde 0 1.0E+03 #DIV/0! NA NA 0 NA 1477 no 759-94-4 EPTC 0 1.0E+03 #DIV/0! NA NA 0 NA 1478 yes 88-12-0 N-Vinyl-2-pyrrolidone 0 1.0E+03 #DIV/0! NA NA 0 NA 1479 no 93-15-2 Methyleugenol 0 1.0E+03 #DIV/0! NA NA 0 NA 1480 no 53112-28-0 Pyrimethanil 0 1.0E+03 #DIV/0! NA NA 0 NA 1481 no 116714-46-6 Novaluron 0 1.0E+03 #DIV/0! NA NA 0 NA 1482 yes 96-09-3 Styrene oxide 0 1.0E+03 #DIV/0! NA NA 0 NA 1483 no 111-77-3 Diethylene glycol monomethyl ether 0 1.0E+03 #DIV/0! NA NA 0 NA 1484 yes 1936-15-8 C.I. Acid Orange 10 0 1.0E+03 #DIV/0! NA NA 0 NA 1485 no 68-12-2 N,N-Dimethylformamide 0 1.0E+03 #DIV/0! NA NA 0 NA 1486 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 330-54-1 Diuron 0 1.0E+03 #DIV/0! NA NA 0 NA 1487 yes 145701-21-9 Diclosulam 0 1.0E+03 #DIV/0! NA NA 0 NA 1488 yes 112-72-1 1-Tetradecanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1489 yes 1118-92-9 N,N-Dimethyloctanamide 0 1.0E+03 #DIV/0! NA NA 0 NA 1490 no 94-81-5 MCPB 0 1.0E+03 #DIV/0! NA NA 0 NA 1491 yes 928-96-1 (Z)-3-Hexen-1-ol 0 1.0E+03 #DIV/0! NA NA 0 NA 1492 no 139-88-8 7-Ethyl-2-methyl-4- 0 1.0E+03 #DIV/0! NA NA 0 NA 1493 undecanolsulfate, sodium salt no 83-67-0 Theobromine 0 1.0E+03 #DIV/0! NA NA 0 NA 1494 no 131983-72-7 Triticonazole 0 1.0E+03 #DIV/0! NA NA 0 NA 1495 no 2761-24-2 Triethoxypentylsilane 0 1.0E+03 #DIV/0! NA NA 0 NA 1496 no 540-88-5 tert-Butyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1497 no 5407-98-7 Cyclobutyl phenyl ketone 0 1.0E+03 #DIV/0! NA NA 0 NA 1498 no 50-35-1 Thalidomide 0 1.0E+03 #DIV/0! NA NA 0 NA 1499 no 13254-34-7 2,6-Dimethyl-2-heptanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1500 no 56-81-5 Glycerol 0 1.0E+03 #DIV/0! NA NA 0 NA 1501 yes 81-07-2 Saccharin 0 1.0E+03 #DIV/0! NA NA 0 NA 1502 no 121-69-7 N,N-Dimethylaniline 0 1.0E+03 #DIV/0! NA NA 0 NA 1503 no 55290-64-7 Dimethipin 0 1.0E+03 #DIV/0! NA NA 0 NA 1504 yes 68609-97-2 C12-14-Alkyl glycidyl ether 0 1.0E+03 #DIV/0! NA NA 0 NA 1505 no 75-50-3 Trimethylamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1506 no 76-49-3 Bornyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1507 no 76-03-9 Trichloroacetic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1508 yes 64-67-5 Diethyl sulfate 0 1.0E+03 #DIV/0! NA NA 0 NA 1509 no 627-93-0 Dimethyl adipate 0 1.0E+03 #DIV/0! NA NA 0 NA 1510 no 73-22-3 l-Tryptophan 0 1.0E+03 #DIV/0! NA NA 0 NA 1511 no 7632-00-0 Sodium nitrite 0 1.0E+03 #DIV/0! NA NA 0 NA 1512 yes 79-39-0 Methacrylamide 0 1.0E+03 #DIV/0! NA NA 0 NA 1513 no 55335-06-3 Triclopyr 0 1.0E+03 #DIV/0! NA NA 0 NA 1514 yes 8000-41-7 Terpineol 0 1.0E+03 #DIV/0! NA NA 0 NA 1515 no 20780-48-7 3,7-Dimethyloctan-3-yl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1516 no 1563-38-8 2,3-Dihydro-2,2-dimethyl-7- 0 1.0E+03 #DIV/0! NA NA 0 NA 1517 no 62

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 benzofuranol 91-64-5 Coumarin 0 1.0E+03 #DIV/0! NA NA 0 NA 1518 no 74051-80-2 Sethoxydim 0 1.0E+03 #DIV/0! NA NA 0 NA 1519 yes 21564-17-0 2- 0 1.0E+03 #DIV/0! NA NA 0 NA 1520 (Thiocyanomethylthio)benzothiazole yes 25322-69-4 Polypropylene glycol 0 1.0E+03 #DIV/0! NA NA 0 NA 1521 yes 307-24-4 PFHxA 0 1.0E+03 #DIV/0! NA NA 0 NA 1522 no 3734-33-6 Denatonium benzoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1523 yes 288-32-4 Imidazole 0 1.0E+03 #DIV/0! NA NA 0 NA 1524 no 1646-88-4 Aldoxycarb 0 1.0E+03 #DIV/0! NA NA 0 NA 1525 yes 112809-51-5 Letrozole 0 1.0E+03 #DIV/0! NA NA 0 NA 1526 no 120-82-1 1,2,4-Trichlorobenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1527 yes 95266-40-3 Trinexapac-ethyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1528 yes 81335-37-7 Imazaquin 0 1.0E+03 #DIV/0! NA NA 0 NA 1529 yes 108-93-0 Cyclohexanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1530 no 877-24-7 Monopotassium phthalate 0 1.0E+03 #DIV/0! NA NA 0 NA 1531 no 156-43-4 4-Ethoxyaniline 0 1.0E+03 #DIV/0! NA NA 0 NA 1532 no 94-82-6 2,4-DB 0 1.0E+03 #DIV/0! NA NA 0 NA 1533 yes 96-48-0 4-Butyrolactone 0 1.0E+03 #DIV/0! NA NA 0 NA 1534 no 37764-25-3 Dichlormid 0 1.0E+03 #DIV/0! NA NA 0 NA 1535 no 4553-62-2 2-Methylpentanedinitrile 0 1.0E+03 #DIV/0! NA NA 0 NA 1536 no 115-28-6 Chlorendic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1537 no 25638-17-9 Butylnaphthalenesulfonic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1538 sodium salt no 109-55-7 3-(Dimethylamino)propylamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1539 no 67-68-5 Dimethyl sulfoxide 0 1.0E+03 #DIV/0! NA NA 0 NA 1540 no 123-35-3 Myrcene 0 1.0E+03 #DIV/0! NA NA 0 NA 1541 yes 95-16-9 Benzothiazole 0 1.0E+03 #DIV/0! NA NA 0 NA 1542 no 2593-15-9 Etridiazole 0 1.0E+03 #DIV/0! NA NA 0 NA 1543 yes 118134-30-8 Spiroxamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1544 no 33956-49-9 Codlelure 0 1.0E+03 #DIV/0! NA NA 0 NA 1545 yes

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 123-05-7 2-Ethylhexanal 0 1.0E+03 #DIV/0! NA NA 0 NA 1546 no 2416-94-6 2,3,6-Trimethylphenol 0 1.0E+03 #DIV/0! NA NA 0 NA 1547 no 1260-17-9 Carminic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1548 no 149-57-5 2-Ethylhexanoic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1549 no 5536-61-8 Sodium methacrylate 0 1.0E+03 #DIV/0! NA NA 0 NA 1550 no 91-62-3 6-Methylquinoline 0 1.0E+03 #DIV/0! NA NA 0 NA 1551 no 4437-85-8 Butylene carbonate 0 1.0E+03 #DIV/0! NA NA 0 NA 1552 no 7779-27-3 1,3,5-Triethylhexahydro-s-triazine 0 1.0E+03 #DIV/0! NA NA 0 NA 1553 yes 91-59-8 2-Naphthylamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1554 no 58-85-5 Biotin 0 1.0E+03 #DIV/0! NA NA 0 NA 1555 no 5850-86-2 C.I. Acid Orange 8, monosodium salt 0 1.0E+03 #DIV/0! NA NA 0 NA 1556 no 52918-63-5 Deltamethrin 0 1.0E+03 #DIV/0! NA NA 0 NA 1557 yes 69-72-7 Salicylic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1558 yes 54-62-6 4-Aminofolic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1559 no 1445-75-6 Diisopropyl methylphosphonate 0 1.0E+03 #DIV/0! NA NA 0 NA 1560 no 23950-58-5 Propyzamide 0 1.0E+03 #DIV/0! NA NA 0 NA 1561 yes 486-56-6 Cotinine 0 1.0E+03 #DIV/0! NA NA 0 NA 1562 no 6359-90-6 C.I. Acid Yellow 34, monosodium 0 1.0E+03 #DIV/0! NA NA 0 NA 1563 salt no 144-49-0 Fluoroacetic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1564 no 1214-39-7 N-Benzyladenine 0 1.0E+03 #DIV/0! NA NA 0 NA 1565 yes 111-82-0 Methyl dodecanoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1566 no 1143-38-0 Anthralin 0 1.0E+03 #DIV/0! NA NA 0 NA 1567 no 36631-30-8 Triisodecyl trimellitate 0 1.0E+03 #DIV/0! NA NA 0 NA 1568 no 34451-19-9 Butyl (2S)-2-hydroxypropanoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1569 no 34014-18-1 Tebuthiuron 0 1.0E+03 #DIV/0! NA NA 0 NA 1570 yes 88-72-2 2-Nitrotoluene 0 1.0E+03 #DIV/0! NA NA 0 NA 1571 no 126-11-4 2-(Hydroxymethyl)-2-nitro-1,3- 0 1.0E+03 #DIV/0! NA NA 0 NA 1572 propanediol yes 59-05-2 Methotrexate 0 1.0E+03 #DIV/0! NA NA 0 NA 1573 no 2212-67-1 Molinate 0 1.0E+03 #DIV/0! NA NA 0 NA 1574 yes 141112-29-0 Isoxaflutole 0 1.0E+03 #DIV/0! NA NA 0 NA 1575 yes 64

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 66-27-3 Methyl methanesulfonate 0 1.0E+03 #DIV/0! NA NA 0 NA 1576 no 111-55-7 1,2-Ethanediol diacetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1577 no 142-87-0 Sodium decyl sulfate 0 1.0E+03 #DIV/0! NA NA 0 NA 1578 no 331623-06-4 MK-547 0 1.0E+03 #DIV/0! NA NA 0 NA 1579 no 121-91-5 1,3-Benzenedicarboxylic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1580 no 3913-02-8 2-Butyloctan-1-ol 0 1.0E+03 #DIV/0! NA NA 0 NA 1581 no 25606-41-1 Propamocarb hydrochloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1582 yes 16219-75-3 5-Ethylidene-2-norbornene 0 1.0E+03 #DIV/0! NA NA 0 NA 1583 no 2782-57-2 Troclosene 0 1.0E+03 #DIV/0! NA NA 0 NA 1584 yes 81-81-2 Warfarin 0 1.0E+03 #DIV/0! NA NA 0 NA 1585 yes 181640-09-5 SR144190 0 1.0E+03 #DIV/0! NA NA 0 NA 1586 no 25498-49-1 Tripropylene glycol monomethyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1587 ether no 29387-86-8 Propylene glycol monobutyl ether 0 1.0E+03 #DIV/0! NA NA 0 NA 1588 no 188425-85-6 Boscalid 0 1.0E+03 #DIV/0! NA NA 0 NA 1589 no 53894-23-8 Triisononyl trimellitate 0 1.0E+03 #DIV/0! NA NA 0 NA 1590 no 27090-63-7 N,N,N',N'-Tetrabutyl-1,6- 0 1.0E+03 #DIV/0! NA NA 0 NA 1591 hexanediamine no 17465-86-0 gamma-Cyclodextrin 0 1.0E+03 #DIV/0! NA NA 0 NA 1592 no 872-50-4 N-Methyl-2-pyrrolidone 0 1.0E+03 #DIV/0! NA NA 0 NA 1593 no 66456-53-9 Adipic acid, polypropyleneglycol, 0 1.0E+03 #DIV/0! NA NA 0 NA 1594 laurate no 88-41-5 2-tert-Butylcyclohexyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1595 no 123122-55-4 Candoxatril 0 1.0E+03 #DIV/0! NA NA 0 NA 1596 no 131-11-3 Dimethyl phthalate 0 1.0E+03 #DIV/0! NA NA 0 NA 1597 yes 111-11-5 Methyl octanoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1598 no 96-29-7 2-Butanone oxime 0 1.0E+03 #DIV/0! NA NA 0 NA 1599 no 512-56-1 Trimethyl phosphate 0 1.0E+03 #DIV/0! NA NA 0 NA 1600 no 108-44-1 3-Methylaniline 0 1.0E+03 #DIV/0! NA NA 0 NA 1601 no 532-02-5 Sodium 2-naphthalenesulfonate 0 1.0E+03 #DIV/0! NA NA 0 NA 1602 no 24307-26-4 Mepiquat chloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1603 yes 177785-47-6 PharmaGSID_47261 0 1.0E+03 #DIV/0! NA NA 0 NA 1604 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 138-86-3 Limonene 0 1.0E+03 #DIV/0! NA NA 0 NA 1605 yes 124-76-5 Isoborneol 0 1.0E+03 #DIV/0! NA NA 0 NA 1606 no 1698-60-8 Chloridazon 0 1.0E+03 #DIV/0! NA NA 0 NA 1607 yes 93-92-5 Benzenemethanol, alpha-methyl-, 0 1.0E+03 #DIV/0! NA NA 0 NA 1608 acetate no 140-56-7 Fenaminosulf 0 1.0E+03 #DIV/0! NA NA 0 NA 1609 yes 149979-41-9 Tepraloxydim 0 1.0E+03 #DIV/0! NA NA 0 NA 1610 yes 107-54-0 3,5-Dimethyl-1-hexyn-3-ol 0 1.0E+03 #DIV/0! NA NA 0 NA 1611 no 124-13-0 Octanal 0 1.0E+03 #DIV/0! NA NA 0 NA 1612 no 139290-65-6 Volinanserin 0 1.0E+03 #DIV/0! NA NA 0 NA 1613 no 55589-62-3 Acesulfame potassium 0 1.0E+03 #DIV/0! NA NA 0 NA 1614 no 300-76-5 Naled 0 1.0E+03 #DIV/0! NA NA 0 NA 1615 yes 124-04-9 Hexanedioic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1616 no 36653-82-4 1-Hexadecanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1617 yes 105-21-5 1,4-Heptanolide 0 1.0E+03 #DIV/0! NA NA 0 NA 1618 no 822-06-0 1,6-Diisocyanatohexane 0 1.0E+03 #DIV/0! NA NA 0 NA 1619 no 85-41-6 Phthalimide 0 1.0E+03 #DIV/0! NA NA 0 NA 1620 no 87-62-7 2,6-Dimethylaniline 0 1.0E+03 #DIV/0! NA NA 0 NA 1621 no 314-40-9 Bromacil 0 1.0E+03 #DIV/0! NA NA 0 NA 1622 yes 111-96-6 Bis(2-methoxyethyl) ether 0 1.0E+03 #DIV/0! NA NA 0 NA 1623 no 122008-85-9 Cyhalofop-butyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1624 yes 107-21-1 Ethylene glycol 0 1.0E+03 #DIV/0! NA NA 0 NA 1625 yes 103-69-5 N-Ethylaniline 0 1.0E+03 #DIV/0! NA NA 0 NA 1626 no 129-06-6 Sodium warfarin 0 1.0E+03 #DIV/0! NA NA 0 NA 1627 yes 112-07-2 2-Butoxyethyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1628 no 102-27-2 N-Ethyl-3-methylaniline 0 1.0E+03 #DIV/0! NA NA 0 NA 1629 no 112733-06-9 Zenarestat 0 1.0E+03 #DIV/0! NA NA 0 NA 1630 no 114311-32-9 Imazamox 0 1.0E+03 #DIV/0! NA NA 0 NA 1631 yes 110-26-9 N,N'-Methylenebisacrylamide 0 1.0E+03 #DIV/0! NA NA 0 NA 1632 no 106-49-0 4-Methylaniline 0 1.0E+03 #DIV/0! NA NA 0 NA 1633 no 102-82-9 Tributylamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1634 no 140-08-9 Tris(2-chloroethyl) phosphite 0 1.0E+03 #DIV/0! NA NA 0 NA 1635 no 66

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 760-23-6 3,4-Dichloro-1-butene 0 1.0E+03 #DIV/0! NA NA 0 NA 1636 no 58-56-0 Pyridoxine hydrochloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1637 no 120-36-5 Dichlorprop 0 1.0E+03 #DIV/0! NA NA 0 NA 1638 yes 105-87-3 Geranyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1639 no 101-10-0 Cloprop 0 1.0E+03 #DIV/0! NA NA 0 NA 1640 no 111988-49-9 Thiacloprid 0 1.0E+03 #DIV/0! NA NA 0 NA 1641 no 51580-86-0 Sodium dichloro-s-triazinetrione 0 1.0E+03 #DIV/0! NA NA 0 NA 1642 dihydrate yes 79098-20-7 4-Chloropentylbenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1643 no 7775-27-1 Sodium persulfate 0 1.0E+03 #DIV/0! NA NA 0 NA 1644 no 609-54-1 2,5-Dimethylbenzenesulfonic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1645 no 57-55-6 1,2-Propylene glycol 0 1.0E+03 #DIV/0! NA NA 0 NA 1646 yes 7287-19-6 Prometryn 0 1.0E+03 #DIV/0! NA NA 0 NA 1647 yes 75-60-5 Dimethylarsinic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1648 yes 62-73-7 Dichlorvos 0 1.0E+03 #DIV/0! NA NA 0 NA 1649 yes 706-14-9 gamma-Decanolactone 0 1.0E+03 #DIV/0! NA NA 0 NA 1650 no 57-14-7 1,1-Dimethylhydrazine 0 1.0E+03 #DIV/0! NA NA 0 NA 1651 no 108-39-4 m-Cresol 0 1.0E+03 #DIV/0! NA NA 0 NA 1652 yes 110-91-8 Morpholine 0 1.0E+03 #DIV/0! NA NA 0 NA 1653 yes 115-96-8 Tris(2-chloroethyl) phosphate 0 1.0E+03 #DIV/0! NA NA 0 NA 1654 no 111-69-3 Hexanedinitrile 0 1.0E+03 #DIV/0! NA NA 0 NA 1655 no 110-63-4 1,4-Butanediol 0 1.0E+03 #DIV/0! NA NA 0 NA 1656 no 108-94-1 Cyclohexanone 0 1.0E+03 #DIV/0! NA NA 0 NA 1657 yes 11099-07-3 Glyceryl stearates 0 1.0E+03 #DIV/0! NA NA 0 NA 1658 no 130-14-3 Sodium 1-naphthalenesulfonate 0 1.0E+03 #DIV/0! NA NA 0 NA 1659 no 50-78-2 Aspirin 0 1.0E+03 #DIV/0! NA NA 0 NA 1660 yes 112-50-5 2-[2-(2- 0 1.0E+03 #DIV/0! NA NA 0 NA 1661 Ethoxyethoxy)ethoxy]ethanol no 108-80-5 Cyanuric acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1662 yes 87-25-2 Ethyl anthranilate 0 1.0E+03 #DIV/0! NA NA 0 NA 1663 no 30560-19-1 Acephate 0 1.0E+03 #DIV/0! NA NA 0 NA 1664 yes

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 56375-79-2 N,N-Dibutyl-N-methylbutan-1- 0 1.0E+03 #DIV/0! NA NA 0 NA 1665 aminium chloride no 69377-81-7 Fluroxypyr 0 1.0E+03 #DIV/0! NA NA 0 NA 1666 no 107-92-6 Butanoic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1667 no 62-23-7 4-Nitrobenzoic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1668 no 645-62-5 2-Ethyl-2-hexenal 0 1.0E+03 #DIV/0! NA NA 0 NA 1669 no 583-78-8 2,5-Dichlorophenol 0 1.0E+03 #DIV/0! NA NA 0 NA 1670 no 133-90-4 Chloramben 0 1.0E+03 #DIV/0! NA NA 0 NA 1671 no 16752-77-5 Methomyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1672 yes 1918-00-9 Dicamba 0 1.0E+03 #DIV/0! NA NA 0 NA 1673 yes 1095-90-5 Methadone hydrochloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1674 no 25496-72-4 Glyceryl monooleate 0 1.0E+03 #DIV/0! NA NA 0 NA 1675 no 34590-94-8 Propanol, 1(or 2)-(2- 0 1.0E+03 #DIV/0! NA NA 0 NA 1676 methoxymethylethoxy)- yes 445295-04-5 CP-671305 0 1.0E+03 #DIV/0! NA NA 0 NA 1677 no 1338-43-8 Sorbitan, mono-(9Z)-9- 0 1.0E+03 #DIV/0! NA NA 0 NA 1678 octadecenoate no 110-16-7 Maleic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1679 no 73-31-4 Melatonin 0 1.0E+03 #DIV/0! NA NA 0 NA 1680 no 5870-93-9 Heptyl butanoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1681 no 89-78-1 dl-Menthol 0 1.0E+03 #DIV/0! NA NA 0 NA 1682 no 143-22-6 2-[2-(2- 0 1.0E+03 #DIV/0! NA NA 0 NA 1683 Butoxyethoxy)ethoxy]ethanol no 26172-55-4 5-Chloro-2-methyl-3(2H)- 0 1.0E+03 #DIV/0! NA NA 0 NA 1684 isothiazolone yes 2627-95-4 1,3-Divinyl-1,1,3,3-tetramethyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1685 disiloxane no 4107-98-6 N,N-Diisopropylaniline 0 1.0E+03 #DIV/0! NA NA 0 NA 1686 no 3296-90-0 2,2-Bis(bromomethyl)-1,3- 0 1.0E+03 #DIV/0! NA NA 0 NA 1687 propanediol no 189003-92-7 Trelanserin 0 1.0E+03 #DIV/0! NA NA 0 NA 1688 no 139-40-2 Propazine 0 1.0E+03 #DIV/0! NA NA 0 NA 1689 yes 2783-94-0 FD&C Yellow 6 0 1.0E+03 #DIV/0! NA NA 0 NA 1690 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 3734-67-6 C.I. Acid Red 1 0 1.0E+03 #DIV/0! NA NA 0 NA 1691 no 64-10-8 Urea, phenyl- 0 1.0E+03 #DIV/0! NA NA 0 NA 1692 no 2451-62-9 Triglycidyl isocyanurate 0 1.0E+03 #DIV/0! NA NA 0 NA 1693 no 122-34-9 Simazine 0 1.0E+03 #DIV/0! NA NA 0 NA 1694 yes 59-67-6 Nicotinic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1695 no 124-40-3 Dimethylamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1696 no 107-75-5 7-Hydroxy-3,7-dimethyloctanal 0 1.0E+03 #DIV/0! NA NA 0 NA 1697 no 13674-84-5 Tris(2-chloroisopropyl)phosphate 0 1.0E+03 #DIV/0! NA NA 0 NA 1698 no 215297-27-1 UK-343664 0 1.0E+03 #DIV/0! NA NA 0 NA 1699 no 79-06-1 Acrylamide 0 1.0E+03 #DIV/0! NA NA 0 NA 1700 no 15214-89-8 2-Acrylamido-2-methyl-1- 0 1.0E+03 #DIV/0! NA NA 0 NA 1701 propanesulfonic acid no 18172-67-3 (-)-beta-Pinene 0 1.0E+03 #DIV/0! NA NA 0 NA 1702 no 210826-40-7 CP-456773 0 1.0E+03 #DIV/0! NA NA 0 NA 1703 no 106-87-6 4-Vinyl-1-cyclohexene dioxide 0 1.0E+03 #DIV/0! NA NA 0 NA 1704 no 110-17-8 Fumaric acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1705 yes 111-15-9 2-Ethoxyethyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1706 no 3681-71-8 (3Z)-3-Hexenyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1707 no 540-18-1 Pentyl butyrate 0 1.0E+03 #DIV/0! NA NA 0 NA 1708 no 2835-95-2 5-Amino-2-methylphenol 0 1.0E+03 #DIV/0! NA NA 0 NA 1709 no 111-62-6 Ethyl oleate 0 1.0E+03 #DIV/0! NA NA 0 NA 1710 no 104-61-0 gamma-Nonanolactone 0 1.0E+03 #DIV/0! NA NA 0 NA 1711 yes 110-65-6 2-Butyne-1,4-diol 0 1.0E+03 #DIV/0! NA NA 0 NA 1712 no 109-52-4 Pentanoic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1713 no 108-45-2 1,3-Benzenediamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1714 no 123-92-2 3-Methylbutyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1715 no 12108-13-3 Manganese, tricarbonyl[(1,2,3,4,5- 0 1.0E+03 #DIV/0! NA NA 0 NA 1716 .eta.)-1-methyl-2,4-cyclopentadien- 1-yl]- no 1541-81-7 4-Dodecylmorpholine 0 1.0E+03 #DIV/0! NA NA 0 NA 1717 no 124-19-6 Nonanal 0 1.0E+03 #DIV/0! NA NA 0 NA 1718 no 188489-07-8 Flufenpyr-ethyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1719 no 69

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 2893-78-9 Sodium dichloroisocyanurate 0 1.0E+03 #DIV/0! NA NA 0 NA 1720 yes 25057-89-0 Bentazone 0 1.0E+03 #DIV/0! NA NA 0 NA 1721 no 13292-46-1 Rifampicin 0 1.0E+03 #DIV/0! NA NA 0 NA 1722 no 461023-63-2 Aplaviroc hydrochloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1723 no 123-00-2 4-Morpholinepropanamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1724 no 194098-25-4 CP-409092 0 1.0E+03 #DIV/0! NA NA 0 NA 1725 no 1907-65-9 N-Butyl-p-toluenesulfonamide 0 1.0E+03 #DIV/0! NA NA 0 NA 1726 no 126-14-7 Sucrose octaacetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1727 no 1191-50-0 Sodium myristyl sulfate 0 1.0E+03 #DIV/0! NA NA 0 NA 1728 no 127-39-9 Sodium 1,4-diisobutyl sulfosuccinate 0 1.0E+03 #DIV/0! NA NA 0 NA 1729 no 93-76-5 2,4,5-Trichlorophenoxyacetic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1730 yes 587-85-9 Diphenylmercury(II) 0 1.0E+03 #DIV/0! NA NA 0 NA 1731 no 1625-91-8 4,4'-Di-tert-butylbiphenyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1732 no 108-11-2 4-Methyl-2-pentanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1733 no 113734-18-2 CP-114271 0 1.0E+03 #DIV/0! NA NA 0 NA 1734 no 16672-87-0 Ethephon 0 1.0E+03 #DIV/0! NA NA 0 NA 1735 yes 94-08-6 Ethyl 4-methylbenzoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1736 no 9016-87-9 Isocyanic acid, 0 1.0E+03 #DIV/0! NA NA 0 NA 1737 polymethylenepolyphenylene ester no 91-22-5 Quinoline 0 1.0E+03 #DIV/0! NA NA 0 NA 1738 no 85264-33-1 (3,5-Dimethyl-1H-pyrazol-1- 0 1.0E+03 #DIV/0! NA NA 0 NA 1739 yl)methanol yes 87820-88-0 Tralkoxydim 0 1.0E+03 #DIV/0! NA NA 0 NA 1740 yes 81335-77-5 Imazethapyr 0 1.0E+03 #DIV/0! NA NA 0 NA 1741 yes 1929-82-4 Nitrapyrin 0 1.0E+03 #DIV/0! NA NA 0 NA 1742 yes 111-46-6 Diethylene glycol 0 1.0E+03 #DIV/0! NA NA 0 NA 1743 no 636-21-5 2-Methylaniline hydrochloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1744 no 184653-84-7 Carabersat 0 1.0E+03 #DIV/0! NA NA 0 NA 1745 no 12427-38-2 Maneb 0 1.0E+03 #DIV/0! NA NA 0 NA 1746 yes 110488-70-5 Dimethomorph 0 1.0E+03 #DIV/0! NA NA 0 NA 1747 yes 114-26-1 Propoxur 0 1.0E+03 #DIV/0! NA NA 0 NA 1748 yes 106-46-7 1,4-Dichlorobenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1749 yes 70

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 108-01-0 Dimethylaminoethanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1750 no 109-02-4 4-Methylmorpholine 0 1.0E+03 #DIV/0! NA NA 0 NA 1751 no 161050-58-4 Methoxyfenozide 0 1.0E+03 #DIV/0! NA NA 0 NA 1752 yes 107-18-6 Allyl alcohol 0 1.0E+03 #DIV/0! NA NA 0 NA 1753 yes 181274-17-9 Flucarbazone-sodium 0 1.0E+03 #DIV/0! NA NA 0 NA 1754 yes 2244-21-5 Potassium dichloroisocyanurate 0 1.0E+03 #DIV/0! NA NA 0 NA 1755 yes 111-21-7 Triethylene glycol diacetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1756 no 119-07-3 Octyl decyl phthalate 0 1.0E+03 #DIV/0! NA NA 0 NA 1757 no 103-65-1 Propylbenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1758 no 108419-33-6 Acetic acid, C8-10-branched alkyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1759 esters, C9-rich no 107-46-0 Hexamethyldisiloxane 0 1.0E+03 #DIV/0! NA NA 0 NA 1760 no 103-23-1 Di(2-ethylhexyl) adipate 0 1.0E+03 #DIV/0! NA NA 0 NA 1761 no 25360-10-5 tert-Nonanethiol 0 1.0E+03 #DIV/0! NA NA 0 NA 1762 no 112-35-6 2-[2-(2- 0 1.0E+03 #DIV/0! NA NA 0 NA 1763 Methoxyethoxy)ethoxy]ethanol no 127-07-1 Hydroxyurea 0 1.0E+03 #DIV/0! NA NA 0 NA 1764 no 112-42-5 1-Undecanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1765 no 103-09-3 2-Ethylhexyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1766 no 112-25-4 2-(Hexyloxy)ethanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1767 no 104-66-5 1,2-Diphenoxyethane 0 1.0E+03 #DIV/0! NA NA 0 NA 1768 no 112-27-6 Triethylene glycol 0 1.0E+03 #DIV/0! NA NA 0 NA 1769 yes 112-14-1 Octyl acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1770 no 4098-71-9 Isophorone diisocyanate 0 1.0E+03 #DIV/0! NA NA 0 NA 1771 no 106-25-2 (2Z)-3,7-Dimethylocta-2,6-dien-1-ol 0 1.0E+03 #DIV/0! NA NA 0 NA 1772 no 110-27-0 Isopropyl tetradecanoic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1773 yes 120-55-8 Diethylene glycol dibenzoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1774 no 114-07-8 Erythromycin 0 1.0E+03 #DIV/0! NA NA 0 NA 1775 no 104-51-8 Butylbenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1776 no 10042-59-8 2-Propyl-1-heptanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1777 no 219714-96-2 Penoxsulam 0 1.0E+03 #DIV/0! NA NA 0 NA 1778 no 53-86-1 Indomethacin 0 1.0E+03 #DIV/0! NA NA 0 NA 1779 no 71

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 207736-05-8 CI-1029 0 1.0E+03 #DIV/0! NA NA 0 NA 1780 no 79-43-6 Dichloroacetic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1781 no 107-51-7 Octamethyltrisiloxane 0 1.0E+03 #DIV/0! NA NA 0 NA 1782 no 117-08-8 Tetrachlorophthalic anhydride 0 1.0E+03 #DIV/0! NA NA 0 NA 1783 no 127-47-9 Retinol acetate 0 1.0E+03 #DIV/0! NA NA 0 NA 1784 no 142-62-1 Hexanoic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1785 no 110-44-1 Sorbic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1786 yes 120-18-3 Naphthalene-2-sulfonic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1787 no 141-43-5 Ethanolamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1788 yes 105-37-3 Ethyl propionate 0 1.0E+03 #DIV/0! NA NA 0 NA 1789 no 50-70-4 D-Glucitol 0 1.0E+03 #DIV/0! NA NA 0 NA 1790 no 106-27-4 Isopentyl butyrate 0 1.0E+03 #DIV/0! NA NA 0 NA 1791 no 106-68-3 3-Octanone 0 1.0E+03 #DIV/0! NA NA 0 NA 1792 no 77-73-6 Dicyclopentadiene 0 1.0E+03 #DIV/0! NA NA 0 NA 1793 no 109-43-3 Dibutyl decanedioate 0 1.0E+03 #DIV/0! NA NA 0 NA 1794 no 80844-07-1 Etofenprox 0 1.0E+03 #DIV/0! NA NA 0 NA 1795 yes 108-59-8 Dimethyl malonate 0 1.0E+03 #DIV/0! NA NA 0 NA 1796 no 487-06-9 5,7-Dimethoxy-2H-chromen-2-one 0 1.0E+03 #DIV/0! NA NA 0 NA 1797 no 112-53-8 1-Dodecanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1798 yes 100-02-7 4-Nitrophenol 0 1.0E+03 #DIV/0! NA NA 0 NA 1799 yes 1119-40-0 Dimethyl glutarate 0 1.0E+03 #DIV/0! NA NA 0 NA 1800 no 123-99-9 Nonanedioic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1801 no 140-38-5 4-Chlorophenylurea 0 1.0E+03 #DIV/0! NA NA 0 NA 1802 no 139-87-7 Ethyl diethanolamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1803 no 103-90-2 Acetaminophen 0 1.0E+03 #DIV/0! NA NA 0 NA 1804 yes 110-05-4 Di-tert-butyl peroxide 0 1.0E+03 #DIV/0! NA NA 0 NA 1805 no 111-87-5 1-Octanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1806 yes 122-88-3 4-Chlorophenoxyacetic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1807 yes 119-53-9 Benzoin 0 1.0E+03 #DIV/0! NA NA 0 NA 1808 no 111-90-0 2-(2-Ethoxyethoxy)ethanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1809 no 122-51-0 Ethyl orthoformate 0 1.0E+03 #DIV/0! NA NA 0 NA 1810 no

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 122-20-3 Triisopropanolamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1811 yes 143-08-8 1-Nonanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1812 no 2996-92-1 Trimethoxyphenylsilane 0 1.0E+03 #DIV/0! NA NA 0 NA 1813 no 1067-25-0 Trimethoxypropylsilane 0 1.0E+03 #DIV/0! NA NA 0 NA 1814 no 100-64-1 Cyclohexanone oxime 0 1.0E+03 #DIV/0! NA NA 0 NA 1815 no 100-54-9 3-Pyridinecarbonitrile 0 1.0E+03 #DIV/0! NA NA 0 NA 1816 no 105-54-4 Ethyl butyrate 0 1.0E+03 #DIV/0! NA NA 0 NA 1817 no 104-67-6 5-Heptyldihydro-2(3H)-furanone 0 1.0E+03 #DIV/0! NA NA 0 NA 1818 yes 79-92-5 2,2-Dimethyl-3- 0 1.0E+03 #DIV/0! NA NA 0 NA 1819 methylenebicyclo[2.2.1]heptane no 1118-46-3 Butyltin trichloride 0 1.0E+03 #DIV/0! NA NA 0 NA 1820 no 106-65-0 Dimethyl succinate 0 1.0E+03 #DIV/0! NA NA 0 NA 1821 no 1112-39-6 Dimethoxydimethylsilane 0 1.0E+03 #DIV/0! NA NA 0 NA 1822 no 110-43-0 2-Heptanone 0 1.0E+03 #DIV/0! NA NA 0 NA 1823 no 111-14-8 Heptanoic acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1824 no 100-51-6 Benzyl alcohol 0 1.0E+03 #DIV/0! NA NA 0 NA 1825 yes 107-07-3 2-Chloroethanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1826 no 108-67-8 1,3,5-Trimethylbenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1827 no 108-91-8 Cyclohexylamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1828 no 100-37-8 N,N-Diethylethanolamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1829 no 100-00-5 1-Chloro-4-nitrobenzene 0 1.0E+03 #DIV/0! NA NA 0 NA 1830 no 106-44-5 p-Cresol 0 1.0E+03 #DIV/0! NA NA 0 NA 1831 no 109-77-3 Propanedinitrile 0 1.0E+03 #DIV/0! NA NA 0 NA 1832 no 58-55-9 Theophylline 0 1.0E+03 #DIV/0! NA NA 0 NA 1833 no 119-64-2 Tetralin 0 1.0E+03 #DIV/0! NA NA 0 NA 1834 yes 124-18-5 Decane 0 1.0E+03 #DIV/0! NA NA 0 NA 1835 no 104-76-7 2-Ethyl-1-hexanol 0 1.0E+03 #DIV/0! NA NA 0 NA 1836 yes 118-93-4 2-Hydroxyacetophenone 0 1.0E+03 #DIV/0! NA NA 0 NA 1837 no 120-71-8 2-Methoxy-5-methylaniline 0 1.0E+03 #DIV/0! NA NA 0 NA 1838 no 163520-33-0 Isoxadifen-ethyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1839 no 101-42-8 Fenuron 0 1.0E+03 #DIV/0! NA NA 0 NA 1840 no 123-66-0 Ethyl hexanoate 0 1.0E+03 #DIV/0! NA NA 0 NA 1841 no 73

NRDC EPA-HQ-OPPT-2015-0305 August, 2015 330-55-2 Linuron 0 1.0E+03 #DIV/0! inactive NA 0 NA 1842 yes 116-06-3 Aldicarb 0 1.0E+03 #DIV/0! NA NA 0 NA 1843 yes 51338-27-3 Diclofop-methyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1844 yes 10043-35-3 Boric acid 0 1.0E+03 #DIV/0! NA NA 0 NA 1845 yes 10265-92-6 Methamidophos 0 1.0E+03 #DIV/0! NA NA 0 NA 1846 yes 104098-48-8 Imazapic 0 1.0E+03 #DIV/0! NA NA 0 NA 1847 no 129630-19-9 Pyraflufen-ethyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1848 no 138261-41-3 Imidacloprid 0 1.0E+03 #DIV/0! NA NA 0 NA 1849 no 57754-85-5 Clopyralid-olamine 0 1.0E+03 #DIV/0! NA NA 0 NA 1850 yes 2675-77-6 Chloroneb 0 1.0E+03 #DIV/0! NA NA 0 NA 1851 yes 101-21-3 Chlorpropham 0 1.0E+03 #DIV/0! NA NA 0 NA 1852 yes 153719-23-4 Thiamethoxam 0 1.0E+03 #DIV/0! NA NA 0 NA 1853 yes 136-45-8 Dipropyl pyridine-2,5-dicarboxylate 0 1.0E+03 #DIV/0! NA NA 0 NA 1854 yes 23564-05-8 Thiophanate-methyl 0 1.0E+03 #DIV/0! NA NA 0 NA 1855 yes 104206-82-8 Mesotrione 0 1.0E+03 #DIV/0! NA NA 0 NA 1856 yes 135410-20-7 Acetamiprid 0 1.0E+03 #DIV/0! NA NA 0 NA 1857 no 123-33-1 Maleic hydrazide 0 1.0E+03 #DIV/0! NA NA 0 NA 1858 yes 144550-36-7 Iodosulfuron-methyl-sodium 0 1.0E+03 #DIV/0! NA NA 0 NA 1859 no 1918-02-1 Picloram 0 1.0E+03 #DIV/0! NA NA 0 NA 1860 yes Table notes:

Chemical list includes all 1860 chemicals in the ToxCast™ iCSS database. Chemicals in the table are ranked by the normalized “potency factor” (lowest

AC50 divided by the total number of active ToxCast™ ER assays. Total number of active ToxCast™ ER assays are out of a possible 18 assays. AC50 and normalized potency factor are in µM. Registered pesticides list obtained from http://scorecard.goodguide.com/chemical-groups/one- list.tcl?short_list_name=pest. AUC model scores obtained from reference in footnote 8. Sources for estrogen standards identified in footnote 27.