Author Index Page Numbers in italics refer to bibliography

Aaron,T.H., Criep,L.H. 180. Adams,M.R., see Litchfield,J. Albert,A., Serjeant,E.P. 176, 207 T., Jr. 386, 409, 432, 441, 207 Aaron, T. H., see Criep, L. H. 465,496 Albert,J.R., see Lish,P.M. 398,427 Adamson,D.W., Barrett,P.A., 449, 465, 466, 495 Aarsen,P.N., Zeegers,A. 15, Billinghurst, J. W., Green, A. Albert, U., see Giertz, H. 444, 30 F .. Jones,T.S.G. 190,192, 489 Abbozzo, G., Genazzani, E., 207 Alberty,J. 387,425, 442, Donatelli, L. 562,570 Adamson, D. W., Barrett, P. A., 452--455,480 Abdel-Galil, A. A. M., Marshall, Billinghurst,J. W., Jones, T. Alberty, J., Huurrekorpi, L. P. B. 114, 122 S.G. 190,207 399, 425, 455, 480 Aborg, e.-H .. Novotny,J., Adamson, D. W., Billinghurst, Alberty,J., Schiede,M. 399, Uvniis,B. 86.90 J.W. 189,194,207 425,455,480 Aborg,e. H., Uvniis,B. 87, 90 Adashek, D., Grossman, M. I. Alberty, J., Takkunen, R. 467, Aborg, C.-H., see Uvniis,B. 58. 46,47,55 480 74. 75, 82, 84-87. 92 Adlerova, E., see Protiva, M. Albinus,M., Sewing.K.F. 2, Abram, L. E., see Cohen, M. B. 201, 212 3, 6, 8, 11, 21, 30, 264, 287, 421,427 Ado,A.D., Abrossimow,W.N. 463,480 Abrams,G., see Lear,E. 566, 453.480 Albrecht, I., see Cort, J. H. 579, 571 Ado, A. D., Ishimova, L. M., 597 Abramson, D. I.. Tuck, S .. Chu, Polner, A. A. 468,480 Aledort, L. M., see Goldman, B. L.S. W., Donatello, T. M. Agarwal, S. L., see Deshmanker, 543,556 22,30 B. S. 442, 486 Aleksandrowicz, D., see Traina, Abramson, D. I., Tuck. S .. Agrup, P., Granerus, G., Ja• V. 442,502 Zayas, A. M., Donatello, cobsson, S., Wetterqvist, H., Alexander. F., Eyre,P., Head, T.M., Chu,L.S. W., Mit• White, T. 142, 143 K. W., Sanford, J. 476.480 chell, R. E. 6,7,30 Ahlstrom,e.G., Johnston,M., Alexander, R. W., see Bush, J. E. Abrossimow, W. N., see Ado,A. Kahlson, G. 110, 122 378,379 D. 453,480 Ahmadi,A., Nemir,P., Jr., Alho,A.V., see Motsay,G.J. Abt, A. F., see Lamson, P. D. 3, Roth,J.L.A., Drabkin,D.L. 580,600 4,17,35 575,594 Al Katib, H., see Graham,J.D. Achenbach, P., Loew, E. R. Ahmed, A., Marshall, P. B. R. 322,331 463,480 303.329 Alksne, J. F. 423, 425 Ackermann,D. 381,425 Ahmed,A.E., see Hanna,P.E. Allan, G., see Levi, R. 1,35, Ackermann,D., Wasmuth, W. 204,206,210,240,247 443,460,495 369, 378, 381, 399, 405, 425, Aibara, S., see Ishida, Y. 375, Allen, G. S., Henderson, L. M., 442,455,480 377.379 Chou, S. N., French. L. A. Ackermann, H., Eichenberger, Aikawa, T., see Ishikawa, E. 27.30 E., Hunziker, F., Lauener, 111,125 Allen,J.E .. see Russo,R.M. H., Schmutz,J. 446,480 Ainsworth,e., Jones, R. G. 569,572 Adam,H.M., Hye,H.K.A. 286,287 Allen,L.E., see Lish,P.M. 568,570 Aitken, M. M., Sanford, J. 476, 449,465,466,495 Adam,H.M., Hye,H.K.A., 480 Waton,N.G. 114,122 Akabori, S., Kaneko, T. 286, Allinger, N. L., see Eliel, E. L. 271,289 Adamik,R., see Baxter,J.H. 287 66,69 Akagi,M., see Tasaka,K. 410, Allison,A.C.. see Orr. T. S. G. Adams,G.K., see Diamond,L. 436 59,72 410,428 Akcasu, A., West,G. B. 469, Allmark, M.G., see LU,F.e. Adams, H. R., see Goth, A. 63, 480 463,496 70, 100, 107 Akin,F.J., Tobia,A.J. 133, Allmark,M.G., see Stephen• Adams, M. D., Hudgins, P. M. 134, 143 son, E. H. 561, 567, 572 23,30 Albert, A. 245 Alonso, L., see Litchfield, J. T., Adams,M.D., see Tobia,A.J. Albert, A., Goldacre, R., Phil• Jr. 386,409,432,441, 465, 23,38 lips,J. 267,287 496 604 Author Index

Alonso, M., see Fraile, A. 138, Altura, B. T., see Altura, B. M. Antonio,A., Funayama 312 145 1, 24-29, 31, 122, 123, 443, Antonio,A .. Rocha e Silva,M. Alonso-de-Florida, F., Castillo, 480, 508,510, 577-580, 584, 460,481 l.del, Garcia,X., Gijon,E. 589,593,595 Antonio, A., see Rocha e Silva, 456,480 Alworth,B.L., see Winbury,M. M. 317-319,332,435 Alonso-de-Florida, F., Castillo, M. 419,437 Appert, H. E., see Flynn, l. T. l.del, Gonzalez,C.C., San• Amann,R., Werle,E. 83,90 584,598 chez,V. 456,480 Amann, R., see Werle, E. 83, Arbesman,e.E., Koepf,G.F., Alonso-de-Florida, F., Cordo• 92 Lenzner,A.R. 421,425 ba, F. 455, 480 Ambache, N., Killick, S. W., Zar, Arbesman,C.E., Koepf,G.F., M.Aboo 440,456,481 Miller,G.E. 421,425,442, Alper,M.H., see Flacke, W. 7, Amundson,M.E., Manthey,l. 446,481 8, 11-15, 21, 34, 400, 429 A. 545,554 Arbesman, e. E., Neter, E., Alpers, H. S., see Geiger, W. B. Anan, S. 382,405,425 Becker,e.F. 468,481 455,488 Andem, M.R., see Haley, T.l. Arborelius, M., Lilja, B., Swen• Alphin, R. S., see Lin, T. M. 121,124 son,E. W., Lindell, S. E., 252,253,291 Anders,M.W., see Hanna,P.E. Hjaltason, S. 16, 21, 32 Alten, P. 1. van, see Conway,A. 206,210 Arborelius, M., see Swenson, E. M. 478,485 Anderson, D. l., Emmlin, N. W. 16,21,38 Altu,G.K., see Clowes,G. HA. 390,416,425 Archer, G. T. 75, 78, 82, 90 lr. 575,597 Anderson, E. G., see Haas, H. L. Archer, R. K. 369, 375, 376, Altura,B.M. 1,23-28,30,31 568,571 378,378 Anderson,F. L., lubiz, W., Tsa• Archer,R.K., Feldberg, W., Altura, B. M. 575, 577-582, jaris,T.l., Kuida,H. 584, Kovacs, B. A. 369, 372, 584-586,589,593,594,595 596 378 Altura,B.M., Altura,B.T. 1, Anderson,F.L., Kuida,H., Archibald,l.L., Benke,G.A. 24-29,31.122.123.443,480, Hecht,H.H. 5,15,17,31 207,207 508,510,577,578,580,584, Anderson, G. W., see Clapp, R. Archibald,l.L., Fairbrother,P., 589,593,595 C. 180,208,409,427 lackson,l.L. 206,207 Altura, B. M., Edgarian, H., Anderson, G. W., see Vaughan, Ariens,E.l. 215,217,245, Altura, B. T. 585, 595 l.R. 180,214 296, 301, 326, 327, 329, 345, Altura, B. M., Hershey, S. G. Anderson,M.M., see Winder, 352, 366 578, 579,595 e. V. 183, 214, 390, 409, Ariens, E. l., de Groot, W. M. Altura,B.M., Hershey,S.G., 413,416,437 333,366 Altura,B.T. 24,31,577, Anderson, M. W., Orton, T.e., Ariens,E.l., van Rossum,l.M., 579,595 Pickett, R. D., Eling, T. E. Koopman, P. 324, 329 Ariens,E.J., Simonis,A.M. Altura, B. M., Hershey, S. G., 547,554 254, 280, 285, 287, 296, 301, Mazzia, V. D. B. 577-580, Anderson, P., Slorach, S. A., 326,329,345,352,366 595 Uvnas,B. 59,69,79,90 Anderson, P., see Riihlich, P. Ariens, E. l., Simonis, A. M., Altura, B. M., Hershey, S. G., van Rossum,l.M. 252, Zweifach, B. W. 579,595 59, 73, 79, 91 Anderson,R.C., see Lee,H.M. 283,287,343,345,365,366 Altura, B. M., Hsu, R., Mazzia. 187,211,448,465,495 Ariens, E. l., see Ellenbroek, B. V.D.B., Hershey,S.G. Anderson, S. M., see Hansch, e. W. l. 352,366 579.595 262,290 Ariens, E. J., see Lehmann, P. A. Altura, B. M., Malaviya, D., Anderson, W., lr., see Maling, 352,366 Reich, C. F., Orkin, L. R. H. 508,510,511 Ariens, E. l., see Lien, E. l. 352, 27,28,31 Anderson, W., lr., see Webster, 367 Altura, B. M., Zweifach, B. W. M.E. 508,512 Ariens,E.l., see Simonis,A.M. 1, 23-25, 28, 31, 121, 123, Andersson,S., Uvnas,B. 80,90 352,365,367 462, 481, 575, 584, 585, 596 Andrako,l., see Stubbins,l.F. Arison, B. H., see Hucker, H. B. Altura, B. M., see Altura, B. T. 345,367 543-545,557 585,596 Andrews, P. R. 230, 245 Arison, B. H., see Porter, e. e. Altura, B. M., see Edgarian, H. Andrus, E. e., Wilcox, H. B., lr. 543,544,558 585,597 456,481 Armitage, P., Herxheimer, H., Altura, B. M., see Halevy, S. Andrus, E.e., see Wilcox, H. B., Rosa, L. 465,481 584, 592, 593, 598 lr. 456,503 Arnold, H., Brock, N., Kiihas, Angyal,S.J., see Eliel,E.L. E., Lorenz,D. 446, 465, Altura, B. M., see Hershey, S. G. 271, 289 481 577, 578, 579, 599 Ankier, S. 1. 474,481 Arnoldsson, H., see Liiwhagen, Altura, B. T., Altura, B. M. Anrep, G. V., Barsoum, G. S., O. 142, 147 585,596 Salama, S., Souidan, Z. Aronson,A.S. 456,481 Altura, B. T., Altura, B. M., 422,425 Arora,R.B., see Seth,S.D.S. Baez, S. 585,596 Antonio, A. 300 370,380 Author Index 605

Arturson, G. 578,596 Austen, K. F., see Goetz!, E. J. Baez, S., see Altura, B. T. 585, Arunlakshana, O. 442, 481 378,379 596 Arunlakshana, 0., Schild, H. O. Austen, K. F., see Ishizaka, T. Baez, S., see Janoff, A. 576, 218, 246, 251, 252, 287, 302, 61, 71 599 330,392,395,414,425 Austen, K. F., see Kaliner,M.A. Baez, S., see Shorr, E. 575, 602 Aschheim, E., Zweifach, B. W. 57, 61, 62, 64, 67, 71, 105, Bagchi, N., see Seth, S. D. S. 423,425 107, 167,172 370,380 Ash,A.S.F.,Schild,H.O. 175, Austen, K. F., see Orange, R. P. Baggiolini,M., see Bicke!,M. H. 207, 252, 253, 287 61,67, 72, 167, 172 521,547,554 Assali,N.S., see Woods,J.R., Austen, K. F., see Stechschulte, Bagnara, J. T., see Turner, C. D. Jr. 20, 39, 469, 503 D.J. 63,73,413,436 585,602 Assem,E.S.K. 509,511 Austen,K.F., see Tauber,A. I. Bailey, B. A., see Richardson, Assem,E.S.K., Chong,E.K.S. 64,73 C. T. 265,292 443,481 Austen, K. F., see Valentine, M. Bain, W. A. 421,425 Assem, E. S. K., Feigenbaum, J. D. 60, 74 Bain,W.A., Broadbent,J.Z., J.r. 113,123 Austen, K. F., see Wasserman,S. Warin, R. P. 389, 409, 421, Assem,E.S.K., Richter,A. W. L 58, 74, 78, 92 425 64,69 Avanzini, F., see Businco,L. Bain,W.A., Heller,F.F., Assem, E. S. K., Schild, H. O. 471, 483 Warin, R. P. 421, 425 61,67,69 Aviado,D.M. 579,596 Baker,C.H., Menninger,R.P. Assem, E. S. K., Schild, H. 0., Aviado,D. M., see Cho, Y. W. 19,22,32 Vickers,M.R. 106, 106, 3, 5, 8, 15,33,585, 586,596 Baker,D.C.,Jr. 509,511 113,123 Awouters, F., Niemegeers,c.J. Bakhle,Y.S., Smith,T.W. Assem,E.S.K., see Wan,B.Y. E., Janssen, P. A. J. 446, 443,481 C. 265,293 481 Baldessarini, R. 1., Kopin, U. Atack, C. 121, 123 Axelrod, J. 153 163, 171 Atanackovic, D., see Flacke, W. Axelrod,J., Daly,J. 162, 171 Baldessarini, R. J., see Snyder, 7, 8, 11-1~ 21, 3~ 40Q 429 Axelrod,J., see Brown, D. D. S. H. 109, 120, 129, 151, Atkins, F. L., Horakova, Z., 134, 144, 156, 171 153, 156, 160, 163, 164, 173 Beaven,M.A. 168 Axelrod, J., see Brownstein, M. Balgooy,J. N. A., van, Marshall, Atkins,F.L., see Webster,M.E. 568,570 F. D., Roberts, E. 132, 133, 163, 164, 167, 173 Axelrod,J., see Molinoff,P.B. 143 Attwood, H. D., see Storstein, O. 153. 172 Balletto,A.1., see Hucker, H. B. 15,38 Axelrod, J., see Palkovits, M. 543-545,557 Augstein, J., Ham, A. L., Lee• 172 Baltzly, R., DeBreuil, S., Ide, ming, P. R. 203, 207 Axelrod,J., see Saavedra,J.M. W. S., Lorz, E. 227, 246 Aures, D., Davidson, W. D., 153, 173 Bangham,A. D., Rees, K. R., Hakanson, R. 111, 123 Axelrod,J., see Snyder, S. H. Shotlander, V. 228, 246 Aures,D., Hakanson,R. 111, 109,114,120,129,132,133, Bank,S., see Barbezat,G.O. 123 134,149 265, 287 Aures,D., Hakanson,R., 151,153,156,160,163,164, Barac,G. 183,207 Schauer,A. 112,123 173 Biminy, E., Nordqvist, P. 417, Aures,D., Johnson,L.R., Way, 420,425 L. W. 44,45,55 Barbe,J. 230,246 Aures,D., Menon,M.K., Yuen, Bach, M. K., Brashler,J. R. 59, Barbe,J., Blanc,A., Hurwic,J. L., Thompson, J. H. 123 61,69 230, 231, 246 Aures,D., Thompson,J.H. Bachrach,W.H., see IVy,A.C. Barbezat, G. 0., Bank, S., Clain, 112, 123 252,290 J., Novis,B., Marks,LN. Aures,D., Winqvist,G., Hans• Back,N., see Wilkens,H.J. 265, 287 son,E. 110,123 469,503 Barbin,G., see Garbarg,M. Aures,D., see Caren,J.F. 45, Backus, B., see Kim,K.S. 132, 120,124,568,571 48, 55 146 Barefoot,R.D., see Tompa, A. S. 269, 293 Aures, D., see Johnson, L. R. Badley,D.N., see Scott,R.S. Barch, G. K., Talbott, M. W. 43-45,48,55,56 566,572 Aures, D., see Menon, M. K. 477, 481 Baer, J. E., see Brodie, B. B. Bareicha, r., Rocha e Silva, M. 116, 127 514,521,554 Austen, K. F., Bloch, K. J. 60, 301, 330, 456, 481 Baer,R., R6ssler,R. 17,32 69 Barer,G.R., Emery,C.J., Austen,K.F., Humphrey,J.H. Baez, S. 23, 32 Mohammed,F.H., 68,69 Baez,S., Hershey,S.G., MungalL L P. F. 477,481 Austen, K. F., Valentine, M. D. Rovenstine,A. 583, 596 Barger, G., Dale,H.H. 41, 55 60,69 Baez,S.,Orkin,L.R. 585,596 Bargmann, W. 439 Austen,K.F., see Becker,E.L. Baez, S., Orkin, L. R., Lorenzo• Barlow,O.W., Beams,A.J. 59,69 J.agisquet.l.A. 584.596 445.481 606 Author Index

Barlow,R.B. 215,218,246, Beaven, M.A. 153, 164, 171 Bellet, S., see Cho, Y. VV. 3, 5, 252,256,287,299, 320, 324, Beaven,M.A., Horakova,Z., 8, 15, 33, 585, 586, 596 330,394,425 Gevers, VV.B. 116, 123 Benacerraf, B., Fischel, E. E. Barnett, A., Malick,J.B., Taber, Beaven,M.A., Jacobsen,S. 444,471,481 R.I. 562,567,570 155, 160, 171 Benacerraf, B., see Binaghi, Baronofsky, I. D., see Campbell, Beaven, M. A., Jacobsen, S., R.A. 412,426 B. 445, 470, 484 Horakova,Z. 110, 123, Benditt, E. P., see Lagunoff, D. Barough,V., Dall,H., Patel,D., 151, 155, 157, 158, 160, 163, 75, 78, 82, 85, 91, 93, 107 Hite,G. 184,207 164, 167-169, 171 Benditt,E.P., see Rowley,D.A. Barre,F.de, see Jacob,R. 217 Beaven,M.A., see Atkins,F.L. 386,435 Barrett,P.A., see Adamson, 168 D.VV. 190,192,207 Beaven,M.A., see Baxter,J.H. Benesch,L., see Lorenz, VV. Barrett, VV. E., Craver, B. N. 163, 164, 167, 171 109, 126 446,481 Beaven,M.A., see Cohen,I.K. Benfey,B.G., see Greeff,K. Barrett, VV. E., Huebner, e. F., 168, 171 457,490 Rutledge, R. A., Dettrich, Beaven,M.A., see Horakova,Z. Benke,G.A., see Archibald, A.,Plummer,A.J. 446,481 164, 167, 172, 586, 587, 599 J.L. 207,207 Barrett,VV.E., see Craver,B.N. Beaven,M.A., see Isaac,L. Bennet,A., Lockett,M.F. 447,462,486 112, 125 465,481 Barsoum,G.S., Gaddum,J.H. Beaven,M.A., see Johnson, Bennett, E. N., see Kessler, E. 370, 379, 586, 587, 596 H.L. 114,125 584,599 Barsoum,G.S., see Anrep, Beaven,M.A., see Kaplan,A.P. Bennich, H., see Stanworth, D. G. V. 422,425 164, 172 R. 60,73 Bartels, E., see Rosenberg, P. Beaven,M.A., see Markley,K. Benslay,D.N., see Lin,T.M. 417,435 163, 164, 167, 172, 440, 496 252,253,291 Barth, H., Niemeyer, J., Beaven,M.A., see Markley,K. Benson,A.J., Horton,B.T. 8, Lorenz, VV. 134, 143, 444, 585-587. 590, 592, 593, 600 32 481 Beaven,M.A., see Shaff,R.E. Bentley,A.J., Jackson,R.T. Barth, H., see Lorenz, VV. 109, 169, 173 25,32 126, 132, 139, 143, 146, 147 Beaven,M.A.,'see VVebster, Benvifnati, S., see Businco, L. Bartlet,A. L. 7, 9, 12-14, 21, M.E. 163, 164, 167, 173 471,483 32, 252, 287, 400, 425, 457, Beck,E., see Bernauer, VV. Beraldo, VV. T., DiasdaSilva, VV. 458,481 442,462,464,482 386,426 Bartley,T.D., see Swenson, Beck,E., see Hahn,F. 461, Beraldo, VV. T., RochaeSilva, E. VV. 16, 21, 38 462,490 M. 298-300,330 Bartosch, R., Feldberg, VV., Beck,L. 1,23,32,422,425 Beraldo, VV. T., see Nagel, E. 386,425 Becker, C. F., see Arbesman, Rochae Silva, M. 296-301, Basold,A., see Friebel, H. 465, e. E. 468,481 312,332 488 Becker,C.G., Murphy,G.E. Berchtold, R., see Hirt, R. 228, Baudry,M., Martres,M.-P., 26,32 247 Schwartz,J.-C. 110,119, Becker,E.L., Austen,K.F. Berg, B., Granerus,G., 123 59,69 Johansson, M.-B., VVestling, Bauer, G., Nowak,H. 546,554 Becker,E.L., Henson,P.M. H., VVhite, T. 115, 123, Bauer, H., see Snyder, S. H. 57,60,64,67,68,69 140, 142, 143 114, 129 Becker,E.L., Mota,l., VVong, Berg, B., Granerus, G., VV est• Baumann,R., see Busch,E. D. 443,444,473,481 ling, H., VVhite, T. 142, 144 471,483 Becker, E. L., Rappaport, B. Z. Berg, B., VVetterqvist, H., VVhite, Baur,H., see Edlbacher,S. 421,425 T. 143,144 381. 428 Beckett,A. H., Hewick,D. S. Bergendorff,A., Uvnas,B. 58, Baxter. J. H. 58,66,69 539,554 69,86,90 Baxter,J.H., Adamik,R. 66, Beckett,A. H., VVilkinson, Bergendorff, A., see Uvnas, B. 69 G. R. 532,554 58, 74,75,82, 85, 86, 92 Baxter,J.H., Beaven,M.A., Bedigian,E., see Maudsley, Berger,S., see Movat, H.Z. Horakova,Z. 163, 164, D.V. 45,54,56,265,292 467,498 167, 171 Beears,VV.L., see Huttrer,C.P. Bergmark,J., Granerus,G. Beall,G.N. 140, 142, 143 180,210,409,430 139,144 Beams,A.J., see Barlow,O. VV. Beebe,A.J., see Stubbins,J.F. Bergqvist, U., Samuelsson, G., 445,481 345,367 Uvnas, B. 78,82,85,90 Beard, J. VV., see Butler,V. 4, Beer,E.J.de, see Castillo,J.e. Bergqvist. U .. see Uvniis. B. 32 388,398,409,427 84,92 Beardsley,A.C., see Glenn, Bekemeier,H., Giessler,A.J., Berk, J. E., see Shay, H. 378, T.M. 598 Hirschelmann, R. 506, 511 380 Beaumariage, M. L., see Beld,A.J. 217 Berk,J.L. 578,579,596 Lecomte,]. 470, 477, 494, BeJeslin,D.B. 4,32 Berkson,]. 393,426 588, 591, 600 Belleau, B. 322, 330 Bernauer, VV. 461,482 Author Index 607

Bernauer, W., Brandenbusch, Bevan.J.A., Duckles,S.P .• Black,J. W., Owen,D.A.A., G. 462,482 Lee,T.J.-F. 27.32 Parsons, M. E. 5, 6, 32, Bernauer, W., Bundschu,D., Bhalla, T. N., see Gupta, M. 8. 469,482 Filipowski, P. 464, 482 462.490 Black,J. W., Spencer, K. E. V. Bernauer, W., Christoffel, R. Bhargava,K.P., Nath,R., Palit, 264,285,287 464,482 G. 475,482 Black,J. W., see Brimblecombe, Bernauer, W., Filipowski, P. Bhide, N. K., see Jayasundar, S. R. W. 265,288 464,482 370, 373, 375-377, 379 Black,J.W., see Durant,G.J. Bernauer, W., Giertz, H., Bickel, M. H., Baggiolini, M. 255,256,289 Hahn,F., Schmutzler, W., 521. 547, 554 Black,J.W., see Wyllie,J.H. Seseke, G., Sievers, B. 134, 265,281,293 Biedermann, H. P. 464,482 144 Blackburn,C.E.,Ober,R.E. Bernauer, W., Gossow, U., Biel,J. H., Judd,C.r. 201,208 520,554 Hahn,F. 462,463,482 Bier,O.G., seeOvary,Z. 412, Blackwood, J. E., Gladys, C. L., Bernauer, W., Hagedorn, M., 433,466,467,498 Loening, K. L., Petracra,A. Filipowski, P. 463,464, Biernat.J .. see Konturek,S.J. E., Rush,J.E. 268,287 482 265. 291 Blair,A.M., see Goose,J. 64, Bernauer, W., Hahn, F. 461, Bijlsma, U.G., Harms,A. F., 70,473,489 482 Funcke,A. 8. H., Tersteege. Blair, E. L. 42, 55 Bernauer, W., Hahn,F., Beck, H. M., Nauta, W. T. H. Blair, E. L., see Thompson, M. E., Kury, H. 442,462,464, 183.208 H. 265,293 482 Billinghurst,J. W., see Adam• Blakemore, R. c., see Parsons, Bernauer, W., Hahn, F., Giertz, son, D. W. 189, 190, 192, M. E. 257.292 H. 452,461, 482,590,591. 194.207 Blalock,A., Levy,S.E. 17, 18, 596 Binaghi, R. A., Benacerraf, B. 32 Bernauer, W., Hahn,F., 412,426 Blalock, A., see Butler, V. 4,32 Nimptsch, P., Wissler, J. Biozzi,G., Mene,G., Ovary,Z. Blalock, A., see Johnson,G.S. 459,472,482 423.426 5,7,8,35 Bernauer, W., Hahn,F., Resch• Biozzy, G., see Ovary, Z. 423, Blanc, A., see Barbe, J. 230, Bollhagen, S. 457-459, 482 433 231, 246 Bernauer, W., Liebig, R. 464, Birkeland,J. M., Kornfeld, L. Blancuzzi, V., see Perper, R. J. 482 467.482 474,475,499 Bernauer, W., Schanz, H.-M. Bischoff, S., see Pollard, H. 110, Blattberg,8., see Levy, M. N. 461,464,482 120, 127 576,600 Bernauer, W., see Bundschu, D. Bischoff, S., see Schwartz, J. C. Blattberg, W., Levy, M. N. 463,464,483 119. 129, 133, 148 575,596 Bernauer, W., see Giertz, H. Bitman,J., see Wrenn,T.R. Bleidt, B., see Diamond, L. 468,489 137.150 410,428 Bernauer, W., see Hagedorn, M. Bjorklund,A., Hakanson,R., Bloch,J. H., see Lillehei, R. C. 461, 490 Nobin,A., Sjoberg, N.-O. 577-582,600 Bernauer, W., see Hahn, F. 121,123 Bloch.K.J .. Cygan,R. W., Wal• 444, 457-462, 490, 491 Bjura,T. 134,138,144 tin,J. 63,69 Bloch,K.1 .. see Austen,K.F. Bernauer, W., see Liebig, R. Bjura, T., Lindberg, S., West• 60,69 443,460,495 ling, H. 141, 144 Bjura. T., Westling, H., Wetter• Bloch, K. J., see Stechschulte, D. Bernauer, W., see Molls, M. qvist,H. 113,114,119,123, J. 413,436 464,497 134. 138, 144 Bloch, K. J., see Valentine, M. Bernstein, r. B., see Feinberg, S. Black. 1. W. 49,55,421,426 D. 60,74 M. 564,570 Black,J. W., Duncan, W.A.M., Bloom, 8. M., Goldman, r. M. Bernstein,J., see Poisner,A.M. Durant,C.J., Ganellin, C. R., 256,288,329,330 63, 73 Parsons, E. M. 3, 5, 12, 24, Bloom, F. E., see Siggins, G. R. Bernstein, T. B., Feinberg, 32,49, 50,55,252, 259, 260, 568,572 S. M. 409,426 263. 281, 287, 376. 379, Bloom, G. D., Chakravarty, N. Bernstein, T. 8., see Feinberg. 386,392,393,401,421,426, 96, 106, 106 S. M. 387, 389, 409, 429, 440,458,482,569,570 Bloom, G. D., Haegermark, b. 441,442,447,451, 454, 465, Black,J.W., Duncan,W.A.M., 59,69,79,89,90 487 Emmett, J. c., Ganellin, C. Bloom,G. D., see Helander, H. Berry, C. A., see Faingold, C. L. R .. Hesselbo, T., Parsons, M. F. 75, 90 561-563,569,570 E., Wyllie,J. H. 263-265, Bloom,G.D., see Kruger,P.G. Bertacinni, G., Impicciatore, M. 287 78.79,91 264,287 Black,J. W., Durant,G.J., Blumgart,H.L., see Weiss,S. Best,C.H., McHenry,E.W. 1. Emmett,J.c., Ganellin,C. 6,7, 19,39 32 R. 257, 260, 262, 263, 287 Blyth,D.1. 440,482 Bethge, K. P., see Schmutzler,W. Black.l W., Ganellin.C. R. Bodammer, G., Vogt,W. 443, 444,501 252.287 452,463,482 608 Author Index

Bodenschatz, K., see Netter, K. Bounos,G., McArdle,A. H. Brand,J.J. 561,570 l. 134, 147, 444, 498 575,596 Brand,J.J., Perry, W.L.M. Bohme, H., Schneider, H. 286, Bourne, H. R., Lehrer, R. 1., 411,426 288 Lichtenstein, L. M., Weiss• Brandenbusch, G., see Bokesoy, T.A., Turker, R. K. mann, G., Zurier, R. 61,69 Bernauer, W. 462,482 18,32 Bourne, H. R., Lichtenstein, Brashler,l.R., see Bach,M.K. Bokesoy,T.A., see Ercan,Z.S. L.M., Melmon,K.L. 61, 59,61,69 9, 12, 14, 21, 34, 457, 458, 69 Braude, A. 1., see Gilbert, V. E. 459,487,593,597 Bourne, H. R., see Miller, R. L. 575,598 Boerth, R. 422, 426 164, 165, 172 Braun,G. A., see Taylor, R. l., Boerth,R.C., Ryan,M.J., Bourque, J. E., Loew, E. R. Jr. 116,129 Brody,M.l. 422,426 390,426 Breyer, U., Gaertner, H.l. Bohidar,M., see Van Arman,C. Bourquin,J. P. 208 530,554 G. 505,506,508,512 Bourquin,J. P., see Stoll,A. Breyer, U., Gaertner,H.J., Bohnstedt,R.M., Lanz, W. 182,213 Prox, A. 530,554 467,482 Bousquet, W.F., see Tobia,A.J. Breyer, U., see Gaertner, H. J. Bohr, D. F. 29,32 23,38 529, 530, 538, 556 Bohr,D.F., Greenberg,S., Bouthillier, L. P., see Goldner. Brezenoff, H. E., Lomax, P. Bonaccoursi,A. 29,32 M. 444,489 568,570 Bohr, D. F., see Winklemann, R. Bovaird, L., see Maudsley, D. V. Brigham, K. L., Bowers, R. E., K. 27,39 444,496 Owen,P.l. 476,483 Bovet, D. 180, 208, 246, 251, Brimble,M.l., Wallis,D.1. Boissier, l. R., Ratouis, R., Du• 288, 381, 386, 399, 403, 405, 440,483 mont, c., Taliani, L., Forest, 409,412,416,426, 439, 469, l. 204,208 Brimblecombe, R. W. 569 483 Bokelmann, A., see Greeff, K. Bovet,D., Horclois,R., Brimblecombe, R. W., 457,459,490 Fournel,J. 412,424,426 Duncan,W.A.M., Durant, Bonaccoursi,A., see Bohr,D.F. Bovet, D., Horclois, R., G.J., Emmett,J.C., 29,32 Walthert, F. 180, 208, 389, Ganellin, C. R., Parsons, Bonasera, L., see Tolone, G. 409,424,426 M. E. 265, 283, 285, 288 474,502 Bovet,D., Staub,A.M. 179, Brimblecombe,R. W., Bond, R. F., see Gonzalez, R. R., 208, 381,424,426,446,483 Duncan,W.A.M., Durant, Jr. 581,598 Bovet,D., Walthert,F. 381, G.l., Ganellin,C.R., Bondi, A. 358, 360, 366 389, 399, 405, 406, 409, 412, Parsons,M.E., Black,l.W. Bonfils, S., Lambling, A. 378, 416,424,426 265,288 379 Bovet, D., see Fourneau, E. Brimblecombe, R. W., Green, Boquet,A. 467,482 179, 209, 215, 246, 386, 429 D.M.,Inch,T.D., Borchardt, R. T., see Hanna, Bovet, D., see Pasteur Vallery• Thompson, B. 1. 178, 208 P.E. 205,210,240,247 Radot, P. 470, 498, 499 Brimblecombe,R. W., Owen, Bordeleau,J. M., Saint-Hilaire, Bovet,D., see Staub,A.M. D. A. A., Parsons, M. E. 4, J., luretic, F., Tetreault, L. 381,409,436,445,446,455, 32 565.566,570 501 Brink,F.G. van den 217,218, Boreus, L. O. 456,482 Bovet, D., see Ungar,G. 179, 246 Boreus, L. 0., Chakravarty, N. 214,389,436 Brinkman,C.R., see Woods, 97, 106, 106 Bovet, D., see Vallery-Radot, P. 1.R. 20,39 Borovicka, M., Protiva, M. 405,436 Brinkman, C. R. III, see Woods, Bowden,K., Young,R.C. 201,208 J. R.,Jr. 469,503 177,208 Brittain,R.T., D'Arcy,P.F., Borovicka, M., see Protiva, M. Bowers, R. E., see Brigham, Hunt,J.H. 194, 208, 226, 201,212 K. L. 476,483 234, 236, 246, 388, 426 Borsy,J., see Huzsti,Z. 117, Boyajy, L. D., see White, R. P. 125 562,567,573 Broadbent,J.Z., see Bain, Borsy,J., see Toldy,L. 198, Boyd,G. H.,Jr., see Remington, W.A. 389,409,421,425 213 l. W. 578,601 Broadley, K. J. 9, 12, 14, 21, Bossa,M., see Gattegno,D. Boyd, L. J., see McGavack, 32, 400, 401, 426, 457, 471, 279,289 T. H. 390, 413, 416, 421, 483 Boucard,J. P., see Pascal,J. P. 433 Brock, N., Lorenz, D., 17,37 Bozicevich,J., see Waalkes, Veigel, H. 183, 208: 446, Bouhuys, A., see Douglas, J. S. T. P. 470,503 465,483 398, 410, 428, 462, 486 Brack,W. 181,208 Brock, N., see Arnold, H. 446, Bouhuys,A., see Orehek,J. Bradley,E.C., see Weil,M. H. 465,481 509,511 578,602 Brocklehurst, W. E. 444, 483 Bouhuys,A., see Zuskin, E. Bradley,P.B. 568,570 Brocklehurst, W. E., Humphrey, 398,437 Brady,E. S., see Jones, H. M. J. H., Perry, W. L. M. 473, Bounos,G., Brown,R.A., 513, 514, 523,557 483 Mulder, D. S., Hampson, Brake,C.M., see Hinshaw, Brodie, B. B., Gillette, 1. R., L.G., Gurd,F.N. 575,596 L.B. 18,19,22,34 LaDu,B.N. 549,554 Author Index 609

Brodie, B. B., Udenfriend, S., Brownstein, M., Saavedra, Burka,J.F., Deline,T.R., Baer,J.E., Chenkin,T., J.M., Palkovits,M., Axel• Holroyde,M.C., Eyre,P. Dill, W. 514, 521, 554 rod,J. 568,570 477,483 Brodie,B.B., see Johnson,H.L. Brownstein, M., see Palkovits, Burka,J.F., Eyre,P. 440,476, 114,125 M. 172 483, 509, 511 Brodie, B. B., see Jondorf, W. R. Brownstein, M.. see Saavedra, Burke, M., see Cohen, M. B. 535, 557 J.M. 153,173 421,427 Brody,A. W., see DuBois,A. B. Bruce, R. B., Turnbull, L. B., Burkhalter, A., see Shore, P. A. 410,428 Newman,1.H., Pitts,J.E. 151,155,173 Brody,M.J. 23,32 535,555 Buriand,W.L.. Simkins,M.A. 265,288 Brody,M.J., see Boerth,R.C. Bruno, R., see Tolone, G. 474, 422,426 502 Burn,J. H. 1, 32 Brody,M.J., see Powell,J.R. Burn,J.H., Dale,H.H. 23,32 Brunson, J. G., Kalina, R. E., 1, 3, 6, 16, 24, 25, 37, 401, Burn,J.H., Rand,M.J. 400, Eckman, P. L. 590, 596 422, 434, 469, 499, 506, 511 426 Brunson, J. G., see Izard, S. R. Brody,M.J., see Ryan,M.J. Burns,J.J. 551,555 463,493 23,38 Burns,J.J., Conney,A.H., Broughton, B. J. 466, 483 Bucher, K. 297, 301, 330, 443, Dayton,P.G., Evans,C., 483 Brousseau, D., see Mayer,R.L. Martin,G.R., Taller,D. 412,432,439, 465, 474, 497. Bucher, K., see Meier, R. 381, 549,551,552,555 589-591, 600 387,388,409,412,417,433, Burns, J. J., Conney, A. H., Brown,A.M. 589,590,596 442,449,451,455,462,471. Koster, R. 529,549,551, 497 Brown, B., see Snyder, S. H. 555 121, 129 Buchholz, R., Hahn, F., Plester, Burns,J.J., Evans,C. 552,555 D. 462,483 Burns,J.J., Evans,C., Trousof. Brown,B.B., Werner,W.H. N. 552,555 389, 426, 446, 463, 467, 474, Buck,S.H., see Yellin,T.O. Burns,J.J., see Conney,A.H. 483 506,512 Biilbring,E., Wajda,L. 417, 529, 549-552, 555, 563, 570 Brown,B.B., Werner,H., Burns,J.J., see Kuntzman,R. Peters, E. L. 387, 389, 409, 426 Buffoni, F. 132, 133, 144 178,211, 521, 526--529, 531, 426 558 Buffoni, F., Giotti, A. 9, 10,32 Brown, B. B., see Teutsch, G. Burrows, L., see Goldman, B. 569,573 Bugg, C. E., see Thewalt, U. 543,556 279,293 Brown, C. R., Shroff, P. F., Bursztyn, P., see Furchgott, Forrest, W. H. 561, 563, Buhler, D. R. 536,555 R.F. 324,328,330 566,570 Buhler, D. R., Harpootlian, H., Busch, E., Maass, B., Baumann, Brown,C.R., see Teutsch,G. Johnston, R. L. 536, 537, R. 471,483 569,573 555 Bush, J. E., Alexander, R. W. Brown,D.D., Tomchick,R., Bukantz, S. c., see Dammin, 378,379 Axelrod, J. 134, 144, 156, G.J. 442,471,486 Businco, L., Benvifnati, S., 171 BuII.H.B.,seeWells,J.A. 251, Avanzini, F. 471, 483 Brown, E. A., Fox, L. A., Maher, 293 Busse,W.W., Sosman,J. 440, J.P., Nobili,C., Norton, Bullock, J., see Galant, S. P. 484 R.C., Sannella, T. 185,208 421. 429, 430 Butler.V., Beard,J.W., Brown,H., see Hook,W.A. Buitsma, T., see Nauta, W. Th. Blalock, A. 4,32 58,71 232, 247 Butt,A.A., Collier,H.O.J., Brown, H., see Huff.]. A. 140. Buitsma, T., see Rekker, R. F. Gardiner, P. J., Saedd, S. A. 145 216,234,248, 388, 397, 398, 510,511 403,404,434 Bye, c., see Peck,A. W. 569, Brown,H.C.,Okamoto,Y. 572 229,246 Bunce,R., see Galvin,M.J.,Jr. 112,124 Byfield,J.E., see Rangel,D.M. Brown,J.H .. Mackey,H.K., 575,601 Riggilo, D. A., Schwartz, Bundschu,D., Bernauer, W., N. L. 444, 483 Filipowski, P. 463,464,483 Bundschu, D., see Bernauer, W. Brown, M. L., see Rosenthal, Cabrera,G., Thompson,J.E. 464,482 S. R. 442, 445, 450, 455, 417,420,426 Burawoy, A., Spinner, E. 228, 456,500 Caddell, H. M., see Remington, 246 J.W. 578,601 Brown, N., see Rosenthal, S. R. Burchall,1.. see Kuntzman,R. Calman,C., see Ederstrom, 405,435 178,211 H.E. 590-592,597 Brown,R.A., see Bounos,G. Burgen, A. S. V. 324, 330 Calvoer, R., see Lorenz, W. 575,596 Burger, A. 285, 288 139, 147 Brown,R.E., see Vroom,F.Q. Burgess, B. F., Jr., see Cambridge, G. W., Holgate, 543,559 DuBois,A.B. 410,428 J. A. 300, 330, 387,426 Browne, J. S. L., see Rose, B. Burk. D., see Lineweaver, H. Cameron,A., see Craver,B.N. 588,601 301,331 447,462,486 610 Author Index

Campaigne,E., Lesuer, W.M. Cass, R., Marshall, P. B., Riley, Chakravarty, N., see Boreus, 180,208 J.F. 474,484 L.O. 97, 106, 106 Campbell, B. 508,511 Castellucci,A. 112, 123 Chakravarty, N., see Johansen, Campbell, B., Baronofsky, Castillo, J. C. 454, 484 T. 58,71,102,103,105,107 I.D., Good,R.A. 445, Castillo,J.C., deBeer,E.J. Chakravarty, N., see 470,484 398, 427, 454, 484 Svendstrup, F. 10 I, 108 Campbell, W. B., Itskovitz, Castillo,J.C., deBeer,E.J., Chakrin,L.W., Krell,R.D., H.D. 22,33 Jaros,S.M. 388, 409, 427 Mengel,l., Young,D., Campen, M. G. van, see Castillo, J. del, see Alonso-de• Zaher, C., Wardell,J.R.,Jr. Tilford, C. H. 184, 213 Florida, F. 456, 480 440,484 Cannan, R. K., see Keston, A. S. Casy,A. F. 186, 208, 216, 225, Chambon,M., Jourdan,F., 152, 172 234,381 Martin, P. 585-587, 596 Cannon, W. B. 575,576,596 Casy,A.F., Ison,R.R. 187, Chand, N., Carlson, H. c., Canterbury, E. A., see Lovejoy, 193, 196, 208, 240, 242, 246 Eyre,P. 477,484 H.B. 184,211 Casy,A.F., Parulkar,A.P. Chand,N., Eyre,P. 440, 444, Cany,J., Huidobro,H. 184, 187,208 484 208 Casy,A.F., Pocha,P. 186, Chang,J., see Moore, T.C. Capurro,N., Levi,R. 401, 187,208 116,127 426,440,458-460,484 Casy,A.F., see Ham,N.S. Chang,K.J., see Cuatrecasas, Capurro,N., see Levi,R. 2,4, 182,210 P.G. 295,330 9, 12, 13, 35, 401, 432, 440, Casy,A. F., see Ison, R. R. Changeux,J. P. 295, 330 459,495 189-191,210,238,247, 312, Changeux,J.P., see Cohen,J.B. Card, W. I., see Makhlouf, 331 295,330 G.M. 46,56 Cattorini,M., see Carminati, Changeux,J.P., see Dupont,Y. Caren, J. F., Aures, D., Johnson, G.M. 463,484 295,330 L. R. 45, 48, 55 Cavallini,G., Mazzucchi,F. Charalampous, K. D., Johnson, Carliner,P.E., see Gay,L.N. 409,427 P.C. 545,555 183,209 Cavallito,C.J., Chafetz,L., Charlier, R., Philippot, E. 398, Carlson,H.C., see Chand,N. Miller,L.D. 532,555 427,442,484 477,484 Caviezel, R., Eichenberger, E., Charpentier,P., Ducrot,R. Carlsson,A., Lindqvist,M. Kidder, H., Lauener, H., 197,208 567,570 Stille, G. 446, 484 Charpentier,P., Gaillot,P., Carlsson,C., Ritzen, M. 88,90 Cecil,H.C., see Wrenn,T.R. Gaudechon,J. 197,208 Carlton,J.A., see Levy,D.A. 137,150 Charton, M. 260,261,265,288 63,71 Celice,J., Perrault,M., Durel,P. Chartrand, S., see Spink, W. W. Carminati, G. M., Cattorini, M. 389,427 585-587,602 463,484 Cerietti,A., see Doepfner, W. Chastain,R. V., McCarty,C.G., Carney, I. F. 466, 484 443,486 Wieland,D.M. 276,288 Caronna,G., Palazzo,S. 201, Cerletti, A., see Romer, D. Chatterjee, I. B., see Nandi,B. K. 208 199,212 115,127 Carroll,P.R., Glover, W.E. Cernyimszky, H., see Kesztyiis, Chatterjee, I. B., see 470,484 L. 455,493 Subramanian,N. 115, 129 Carroll, P. R., Glover, W. E., Cession-Fossion,A., Lecomte, Chatterjee, M. L., Chatterjee, S. Latt, N. 11,33 J. 463,484 218,246 Carroll,P.R., see Glover,W.E. Cession-Fossion, A., see Chatterjee, S., see Chatterjee, 440,470,489 Lecomte,J. 472, 494 M. L. 218,246 Carryer,H.M., Code,C.F. Chattonnet,J., see Jourdan,F. 443,484 Chafetz, L., see Cavallito, C.l. 532,555 590,592,599 Carter, D.C., Forrest,J.A.H., Chedid,L. 589-591, 596 Werner, M., Heading, R. c., Chakravarty, N. 93-95, 97, 98, 100, 101, 104, 106, 106, Chen,G., see Ensor,C.R. 232, Park,J., Shearman,D.J.C. 246 265,288 107, 443, 444, 484 Chen,K.K., see Lee,H.M. Carter, R. D., Joyner, W. L., Chakravarty, N., Goth, A., Sen, P. 63, 69 465,495 Renkin, E. M. 26, 33 Chen,K.K., see Lin,T.M. Carter,R.D., see Renkin,E.M. Chakravarty, N., Hogberg, B., Uvniis, B. 93, 107 252,253,291 26,37,423,434 Chenkin, T., see Brodie, B. B. Carvalho, I. F., see Diniz, C. R. Chakravarty, N., SfI!rensen, H.J. 514, 521,554 576,597 58,69,95,98-101,107 Chess, D., see Rennick, B. 453, Carvalho, I. F., see Chakravarty,N., Svendstrup, 500 Rocha e Silva,M. 413,435 F., SfI!rensen, H.J. 101,107 Chess, D., see Y onkman, F. F. Casas, F., see Fraile,A. 138, Chakravarty, N., Zeuthen, E. 462,504 145 95, 98, 102, 107 Chessin,M., Ecroli,N. 442, Casley-Smith,J. R., Window,J. Chakravarty, N., see Bloom, 484 423,427 G. D. 96, 106, 106 Chiba, S. 469,484 Author Index 611

Chiba, S., Imai, Y. 463, 484 Clapp,R.e., Clark,J. H., Code,e. F., Keating, V.,Jr., Chick,E.A., see Farmer,J.B. Vaughan, J. R., English, Leavitt,M.D.,Jr. 417, 463,487 J.P., Anderson,G.W. 180, 421,427 Chickering, 0., see Loew,E.R. 208,409,427 Code,e.F., see Carryer,H.M. 253,291 Clapp, R. e., see Vaughan, J. R. 443,484 Chien,J., Usami,S. 583, 596 180,214 Code,e. F., see Cody, D. T. Chiesa,A., Dain,D., Meyers, Clark,A.J. 299,330 471,472,485 G.L., Kessler, G.-F., Gold, Clark,A.J., Raventos,J. 391, Code,C.F., see Navert,H. W.M. 469,484 427 133, 147 Chiesara, E., see Kato, R. 550, Clark, G. R., Palenik, Code,D.F., see Leavitt,M.D. 557 G. J. 182,208 417,431 Chinn, H. I., Handford, Clark,J. H., see Clapp,R.e. Cody, D. T., Code, C. F., S. W., Smith,P.K., Cone, 180, 208, 409, 427 Kennedy,J.e. 471, 472, T. E., Jr., Redmond, R. F., Clark,J. H., see Vaughan,J. R. 485 Maloney, J. V., Smith, 180,214 Cody,D.T., see Code,e.F. C. McC. 411,427 Clark,W.G., see Menon,M.K. 471, 485, 585, 588, 597 Chinn,H.I., Smith,P.K. 183, 116,127 Coffman, P. Z., see Michaelson, 185,208,567,570 Clark,W.G., see Nakajima,T. I. A. 151, 172 Chinn, H. I., see Noell, W. K. 133. 147 Cohen,I.K., Beaven,M.A., 564-567,572 Clayton,J.M., see Hansch,e. Horakova, Z., Keiser, H. R. Chipman, P., Glover, W. E. 334,363,366 168, 171 440,485 Cleveland, R. J., see Moore, Cohen,J.B., Changeux,J.P. Chiron,A.E., see Lear,E. 566, T.e. 143,147 295,330 571 Cline,W.H., see Peach,M.J. Cohen, J. B., see Dupont, Y. Cho, A. K., see Isaac, L. 112, 583,601 295,330 125 Close, J. A., Gobert, J. G., Cohen,M.B., Friedman,H.J., Cho,Y.W., Theogaraj,J., Rodriguez,A.M. 530,531, Jonis,J., Burke,M., Abram, Aviado,D.M., Bellet,S. 3, 555 L. E. 421, 427 5, 8, 15, 33, 585, 586, 596 Clowes,G. H.A.,Jr., Cohen,S.G., Franke,F.R., Chong, E. K. S., see Assem, Farrington,G. H., Karlson, E. L. 470, 485 E.S.K. 443,481 Zischneid, W., Cosette, Cohen, Y., see Schwartz,J.-e. G.R., Saravis,e. 575,597 112, 118, 129 Chou, S. N., see Allen, G. S. Clowes,G. H.A.,Jr., Cohn, J. N., Tristani, F. E., 27,30 MacNichol,M .. Voss, H., Khatri, I. M. 579, 597 Christian,J.E., see Lordi,N.G. Altu, G. K., Saravis, e. Cohn, V. H. 134, 144, 163, 171 227,228,247 575,597 Cohn,V.H., Wynn,W. 134, Christoffel, R., see Bernauer, W. Clowes,G.H.A.,Jr., see 144 464,482 Farrington,G.H. 575,598 Cohn,V.H., see Shore,P.A. Christy, M. E., see Engelhardt, Coburn, H., see Waalkes,T.P. 151, 155, 173 E.L. 199,209,543,555 474,503 Cole,H. W., see Thompson, Chu, L. S. W., see Abramson, Coccia, P. F., Westerfeld, W. W. I. D. 549,559, 563 D.1. 6,7,22,30 521,555 Colebatch,H.l.H. 16,33 Church,M.K. 472,485 Cochran, W.G., see Snedecor, Coletta,C.G., see Smith,G.M. Church,M.K., Collier,H.O.J., G. W. 415, 416, 419, 436 564, 565,572 James,G.W.L. 472,485 Cochrane,e.G., Miiller• Collier, H. O. J. 453, 485 Church,M.K., Miller,P. 475, Eberhard,H.J. 60, 70 Collier,H.O.J., Holgate,J.A., 485 Cochrane, e. G., see Morrison, Schachter, M., Shorley, P. G. Cier, J. F., see Hermann, H. D.e. 59,72 411,427 469,492,589,590,599 Cochrane, e. G., see Ranadive, Collier,H.O.J., James,G.W.L. Cieszkowski,M., see Konturek, N. S. 59,60,73,78,91 411,427,452,462,485 S.J. 265,291 Cochrane,e.G., see Weigle, Collier,H.O.J., Piper,P.J. Cirstea, M. 445,446,451,455, W.O. 468,503 411,427 469,485 Cochrane, D. E., see Kanno, T. Collier,H.O.J., see Butt,A.A. 59,71 Cirstea, M., Griinspan, M. 510,511 Code,e.F. 42,46,55,386, 469,485 427, 469, 485, 586, 588, 597 Collier,H.O.J., see Church, Cirstea,M., Suhaciu,G. 441, Code,e. F., Cody,D. T., Hurn, M. K. 472,485 446,455,469,485 M., Kennedy, J. C., Collier,H.O.J., see Piper,P.J. Ciuchta,H.P., Gautieri,R.F. Strickland,M.J. 471, 485, 463,499 20,33 585,588,597 Collier,J. G., Herman,A. G., Claghorn, J. L., see Johnstone, Code, e. F., Hester, H. R. 585, Vane,J.R. 584,597 E. E. 546,557 586, 588,597 Collins, A. D., see Izard, S. R. Clain,J., see Barbezat,G.O. Code,e.F., Hightower,N.C., 463,493 265,287 Hallenbeck,G.A. 50,55 Colquhoun,D. 329, 330 612 Author Index

Colton, C. D., see Engelhardt, Cox,J. S. G. 466,485 Czerwinska, U., Kazimierczak, E.L. 199,209,543,555 Cox,J.S.G., see Orr,T.S.G. W., Wycz6Ikowska,J., Columbic, C., see Titus, E. O. 64,72 Maslinski,C. 478,486 521,559 Coyle,J.T., Henry,D. 153, Czju, N. L., see Guschin, I. S. Cone,T.E.,Jr., see Chinn,H.I. 171 79,90 411,427 Coyle,J.T., see Horn,A.S. Conney,A.H., Burns,J.J. 567,571 Dage,R.C., Hardman,H.F. 549-552,555 Craig,J.P., Wilhelm,D.L. 256,288 Conney,A.H., Davidson,C., 442,467,485 Dahlquist, R., Diamant, B. Gastel,R., Burns,J.J. 549, Craig, L. C., see Titus,E.O. 65, 67, 70 552,555 Dahlquist, R., Diamant, B., Conney,A. H., Klutch,A. 551, 521,559 Craps, L. 473, 485 Elwin,K. 58,70 555 Daicoff,G.R., see Swenson, Craps, L., see Inderbitzin, T. Conney, A. H., Michaelson, E.W. 16,21,38 473,493 LA., Burns,J.J. 529, 550, Dailey, R. E., Way, E. L., Craver, B. N., Barrett, W., 551,555, 563,570 Parikh, J. R., Sung, C. Y., Conney,A.H., see Burns,J.J. Cameron,A., Herrold,E., Howie,D. L. 515, 516, 555 Yonkman,F.F. 447,462, 529,549,551,552,555 Dailey,R.E., see Way,E.L. Conovici, L., see Halpern, B. N. 486 513,520,523,524,559 185, 209, 448, 491 Craver, B. N., see Barrett, W. E. Dain,D., see Chiesa,A. 469, Conrad,V. 121,123 446,481 484 Conway,A.M., Alten,P. J. van, Craver,B. N., see Yonkman, Dal,S. 486 Hirata,A.A. 478, 485 F.F. 417,437 Dale, H. 441,486 Cook, D. A. 320, 324, 325, 330 Credner, K., Schelske, E. M. Dale, H. H. 1,23,33,399,427, Cook,T.J., MacQueen,D.M., 218, 246, 387, 427, 464, 486 575, 576, 584, 597 Wittig,H.J., Thornby,J.I., Crescitelli, F., Geissman, T. A. Dale,H.H., Laidlaw,P.P. 2, Lantos, R. L., Virtue, C. M. 417,427 11, 12, 23, 33 421,427 Criep, L. H., Aaron, T. H. 398, Dale, H. H., Richards, A. N. Coombs, R. R. A., see Parish, 427 576, 584,597 W. E. 452,498 Criep, L. H., see Aaron, T. H. Dale, H. H., see Barger, G. 41, Cooperman,J.H., see Ecken• 180,207 55 hoff,J.E. 578,597 Crile,G.W. 575,597 Dale,H.H., see Burn,J.H. 23, Cope,A.C., Fenton,S. W. Crisp, J., see Galant, S. P. 32 199,209 421,430 Dale, M. M., Zilletti, L. 455, Copenhaver, J. H., Jr., Nagler, Critchley, S. R., Prout, K., 486 M. E., Goth,A. 469, 470, Ganellin, C. R., Mitchell, Dall, H., see Barough, V. 184, 485 R.C. 271,273,288 207 Corbascio,A. N., see Smith, Cross, S. A. M. 280, 288, 553, Daly, I. B. de, Peat, S., Schild, N. T. 577-579,602 554,555 H.O. 386,427 Cordoba,F., see Alonso-de• Crowell,J. W., see Guyton, Daly,J., see Axelrod,J. 162, Florida, F. 455, 480 A.C. 582,598 171 Coret, I. A., Hughes, M. J. 440, Cruchaud, S., see Halpern, B. N. Daly,J. W., Manian,A.A. 555 485 444,491 Dammin,G.J., Bukantz,S.C. Coret,I.A., see Hughes,M.J. Csaba, B., Went, M. 471, 472, 442,471,486 10, 35, 401, 430, 440, 492 486 Dandavino,A., see Woods, Cort,J. H., Albrecht,I., Nova• Csaba,B., Went,M., Kassay,L. J. R.,Jr. 469,503 kova, J., Mulder, J. L., J ost, 134,144,472,474,486 Daniels,P.J.L., see Villani,F.J. K. 579,597 Csaba, B., see Kesztylis,1.. 200,214,474,503 Cort,J.H., Jeanjean,M.F., 455,493 Darby,T.D., see Marshall,R.J. Thomson,A.E., Nickerson, 578,600 M. 579,597 Cuatrecasas,P. G., Tell, P. E., Sica, V., Parikh,I., Chang, D'Arcy,P.F., see Brittain,R.T. Cosette, G. R., see Clowes, K.J. 295,330 194, 208, 226, 234, 236, 246, G.H.A.,Jr. 575,597 388,426 Cudkowicz, L., see Storstein, O. Cosette, G. R., see Farrington, 15,38 Datt,I. D., see Rannev, N. V. G. H. 575,598 266,274,277,292 Cotton,F.A., Day,V.M., Cunningham,M.D., see Tislow, Daugherty,M., see DaVanzo, Hazen, E. E., Larsen, S. R. 409,436,532,559 J. P. 562,570 257,288 Curwain,B.P., see Holton,P. DaVanzo,J.P., Daugherty,M., Cotton,F.A., Day, V.M., 264,290 Ruckart, R., Kang, L. 562, Hazen, E. E., Larsen, S., Cutting, W.C., Dodds,E.C., 570 Wong,S.T.K. 257,288 Noble, R. L., Williams, P. C. Davidson,C., see Conney,A.H. Courvoisier, S., Ducrot, R., 16,33 549,552,555 Julou, L., Leau, O. 446, Cygan,R. W., see Bloch,K.J. Davidson, W. D., see Aures, D. 485 63,69 111,123 Author Index 613

Davis,A.J.,Jr., see Marsh,D.F. Dennis, M. W., see Douglas, Diamond,L., Adams,G.K., 409,432 J.S. 398,410,428,462,486 Bleidt, B., Williams, B. 410, Davis,D.l., Hertzman,A.B. Dennis, R. G., Whitmire, R. N., 428 411,427 Jackson, R. T. 26,33 Diana,J.N., Long, S.C., Yao, Davis, L. B., see Joiner, P. D. Denton, C., see Dreyer, N. B. H. 26,33 454,455,493 416,428 Dias da Silva, W., Lepow, l. H. Davis,R.B., see Spink,W.W. Denton, J. J., see Vaughan, J. R. 60, 70 585-587,602 180,214 Dias da Silva, W., see Beraldo, Davis,V.E., see Huff,J.A. De Robertis, E. 295, 330 W. T. 386,426 140, 145 De Robertis, E., Plazas, S. F., Dias da Silva, W., see Mota, l. Dawes,G. S. 419,427 Ochoa,E. 295, 330 443,497 Dawes,G.S., see Ing,H.R. De Robertis, E., see Kataoka, K. Diaz-Guerrero, R., Feinstein, 416,430 568,571 R., Gottlieb,J.S. 561,570 Dawson, C. A., Forrester,T.E., De Robertis, E., see Ochoa, E. Dick, W. c., see Grennan, D. M. Hamilton, L. H. 16,33 295,331 506,511 Dawson, W., Starr,M.S., De Roos,A.M., Rekker,R.F., Dietzman, R. H., see Lillehei, R. West,G.B. 472,486 Nauta, W. Th. 522,555 C. 577-581,600 Dawson,W., West,G.B. 135, De Roos,A.M., see Hespe,W. Dietzman, R. H., see Motsay, G. 144,472,486 521,522,557 J. 580,600 Day, V. M., see Cotton, F. A. Dervinis, A., see Rosenthale, M. Di Gaugi, M. R., see Ederstrom, 257,288 E. 444,500 H.E. 590--592,597 Dayton,P.G., see Burns,J.J. De Schaepdryver,A. 453,486 Dill, W., see Brodie, B. B. 514, 549, 551, 552,555 Deshmanker, B. S., Agarwal, S. 521,554 Dean,P.M. 10,33,400,428 L. 442,486 Dill, W.A.,Glazko,A.J 514, DeBeer, E. J., see Castillo, J. C. Desjardins, L., see Pelletier, G, 518,520,534,555 454,484 374--376,378,380 Dill, W.A., see Glazko,A.J. DeBernardo,R., see Lichten• Dettrich, A., see Barrett, W. E. 514,516-520,556 stein, L. M. 61,66,72 446,481 Di Lorenzo, N. L., see Movat, H. DeBreuil, S., see Baltzly, R. Devereux,D.F., Rice,S.A., Z. 467,498 227,246 Giri,S.N.586,587,597 Dinbar,A., see Rangel,D. M. Decourt, P. 389, 409, 428 De Vries,J., see Harms,A.F. 575,601 Degand,L., see Hahn,F. 441, 215-217,219-222,224, 227, Diniz,C. R., Carvalho, I. F. 490 229, 236, 242, 244, 245, 247, 576,597 Dejonge, M. c., see Funcke, 387,430 Diniz, C. R., see Mares-Guia, M. A. B. H. 201,209 Devys,M. M., see Pascaud,X. B. 301, 331 Delagrave,J., see Gauthier, P. 510,511 Diniz, C. R., see Rezende, L., Jr. 370,379 Dews.P. B., Graham,J. D.P. 402,434 Delagrave,J., see Pelletier,G. 9, 12, 14, 21, 33, 252, 288, Dinwiddie, W.G., see Lee, H.M. 375,380 400,419,428 465,495 Delaunois, A.L., Kordecki, R .. Dews,P.B., see Halpern,B.N. Di Rosa,M., Giroud,J. P., Polet, H., Ryzewski, J. 5,7, 417,430 Willoughby,D.A. 507, 8, 15,33 Deyrup, I.1. 3,5,7,8, 12,33 508,511 Deline, T. R., see Burka, J. F. Deyrup, I.J., Root, W. S. 7, 8, Dismukes,K., Kuhar,M.J., 477,483 33 Snyder,S.H. 169,172 Deline, T. R., see Eyre, P. 476, Dhar, H. L., Sanyal, R. K. 474, Dismukes, K., Snyder, S. H. 487 486 169,172,568,570 Dembinski,A .. see Konturek, Diamant, B. 79, 90, 104, 106, Dittbrenner, M., see Dombro, S.J. 265.291 107 R. 133, 144 DeMello, W. C. 10, 33, 401, Diamant,B., Kruger,P.G. 58, Dixon, F. J., see Weigle, W. O. 428 70 468,503 Diamant, B., Kruger, P. G., Dixon,M., Webb,E.C. 301, Demis,D.l. 131,144 Uvnas, B. 59, 70, 79, 90 330 Demitrescu, T., see Konturek, Diamant, B., Nom,S., Felding, Dixon,W.E., Hoyle,J.C. 7,8, S. J. 265,291 P., Olsen,N., Ziebell,A., 15-17,33 Dempsey, H., see Vroom,F.Q. Nissen,J. 104, 107 Djerassi,C., Scholz,C.R. 181, 543,559 Diamant, B., Uvnas,B. 93,95, 209 Denayer,R., see Morren,H. 107 Djerassi,C., see Huttrer,c.p. 185,212 Diamant, B., see Dahlquist, R. 180, 210, 409, 430 Dencker, H., Kahlson, G., 58, 65, 67, 70 Dobkin,A.B., Malik,K., Kockum, l., Norryd, C., Diamant,B., see Kruger,P.G. Israel, J. S. 566, 570 Rosengren, E. 112, 123, 78,79,91 Dobre, A., see Moisii, L. 508, 139, 144 Diamant, B., see Peterson, C. 511 Denner,J.L., see Smith,M.J. 104,108 Dodds, E. c., see Cutting, W. C. 561,572 Diamond, L. 462, 486 16,33 614 Author Index

Dohlen, H., Nornes, H., Dreyer,N.B., Denton,C. 416, Dunne,F.H., Hollister,L.E. Sjaastad,O., Sjaastad,LJ. V. 428 591,597 141, 144 Dreyer,N.B., Harwood,D. Dupont, Y., Cohen,J. B., Doenicke,A., see Lorenz, W. 409,428 Changeux,J.P. 295, 330 143, 147 Dreyer,N.B., King,J.W. 478, Durand, A., see Filleux• Doepfner, W., Cerletti,A. 486 Blanchard, M. L. 266, 277, 443,486 Dreyer,N.B., see Scudi,J.V. 289 Doerge,R.F. 175,209 381,409,412,435,450,451, Durand-Couturier,A., see Filleux-Blanchard, M. L. Doerr, R. 439, 445, 471, 486 454,455,462,471,501 269,289 Dubnick,B., see Kusner,E.J. Dolowy, W.e., see Thompson, Durant,C.J., see B1ack,J. W. I.D. 549,559,563,573 64,71 3, 5, 12, 24, 32, 49, 50, 55, Dombro,R., Huang,M., Ditt• DuBois, A. B., Brody, A. W., 376, 379, 386, 392, 393, 401, brenner,M., Ragins,H. Lewis,D.H., Burgess,B.F., 421, 426,440, 458, 482, 569, 133,144 Jf. 410,428 570 Domenjoz,R., Jaques,R. 381, Duchene-Marullaz, P., Rispat, Durant,G.J. 257,288 409,422,428,447,486 G., Perriere, J. P., Lambert, Durant,G.J., Emmett,J.C., Donatelli, L., see Abozzo, G. J. 409,428 Ganellin, C. R. 254, 263, 562,570 Duckles, S. P., see Bevan, J. A. 265,278,284,286,288 Donatello, T. M., see Abram• 27,32 Durant,G.J., Emmett,J.e., son,D.I. 6,7,22,30 Ducrot,R., see Charpentier,P. Ganellin,C.R., Roe,A.M. Donoghue,E., see Huebner, 197,208 286,288 e.F. 202,210 Ducrot,R., see Courvoisier,S. Durant,G.J., Emmett,J.C., Dorfman,A., see Schiller,S. 446,485 Ganellin, e. R., White, G. R. 83,85,91 285,288 Ducrot, R., see Halpern, B. N. Dormann,P., see Lorenz, W. Durant,G.J., Ganellin,C.R. 196, 197, 209, 381, 389, 409, Parsons, M. E. 256, 278, 143, 147 430,537,556 Dormann, P., see Thermann, M. 289 2,3,5,7,8, 15, 17,21,38 Dudas, A., see Weisz,I. 195, Durant,G.J., Loynes,J.M., Douglas, D. E., see Francis, L. E. 214 Wright, S. H. B. 254, 289 370, 379, 455, 488 Duff,F., Greenfield,A.D.M., Durant,G.J., Parsons,M.E., Douglas,J. F., see Edelson,J. Shepherd,J. T., Thompson, B1ack,J. W. 255, 256, 289 536,555 I. D. 19,33 Durant,G.J., see Black,J. W. Douglas,J.S., Dennis,M. W., Duff,F., Patterson,G.C., 252, 257, 259, 260, 262, 263, Ridgway,P., Bouhuys,A. Whelan,R.F. 422, 428 281,287 Durant,G.J., see Brimble• 398, 410. 428, 462, 486 Duff, F., Whelan,R.F. 19,33 Douglas, J. S., see Orehek, J. combe,R. W. 265,283, Dugan,J.J., see Yen,S.-S. 285,288 509,511 443,444,504 Durant, G. J., see Ganellin, C. R. Douglas, W. W. 65, 70, 106, Dumont,C., see Boissier,J.R. 26,34,254,289 107 204,208 Durant,G.J., see Parsons,M.E. Douglas, W. W., Kanno, T. Duncan,J.C.G., Waton,N.G. 257,292 463,486 114,123 Durel,P., see Celice,J. 389, Douglas, W. W., Nagasawa,J. 427 106,107 Duncan, W.A. M., see Black. J. W. 3,5, 12,24,32,49,50, Dutta,N.K. 417, 419, 428 Douglas,W.W., see Kanno,T. 55, 252, 259, 260, 263-265, Dutta, N. K., see Panse, M. V. 59,71 281, 287, 386, 392, 393, 401, 586,587,600 Dowell,R.e., Kerr,J.W., Park, 421, 426, 440, 458, 482, 569, Dworetzky, M. 455, 486 V.A. 142,144 570 Dyer,D.C., Gough,E.D. Drabkin, D. L., see Ahmadi, A. Duncan, W. A. M., see Brim• 27,33 575,594 blecombe,R. W. 265, 283, Dzodzoe, Y. C. G., Rosengren, E. Drach,J.C., Howell,J.P. 519, 285,288 111,123 521,555 Dragstedt, C. A., Gebauer• Duner, H. 369 Fuelnegg, E. 386, 428 Duner, H., Liljedahl, S. 0., Pernow,B. 131,144 Ealding, W.D. P., see Wyllie, Dragstedt,C.A., see Wells,J.H. J. H. 265,281,293 Duner, H., Pernow,B. 370, 251, 293, 389, 409, 412, 437, Eaton,D.R., Zaw,K. 279,289 371, 374, 379 469, 503, 591, 602 Ebert, R. H., Graham, R. e. Dreisbach,R.H. 471,486 Dunlop, R. H., see Zarkower, A. 24,33 Drekter,J.J., see McGavack, 137,150 Ebner,C., see Hahn,F. 452, T.H. 183,211,513,516, Dunn, Thelma B., Potter,M.A. 490 518, 523, 524, 558 167,172 Ebnother,A. 234 Dresse,A., see Lecomte,J. Dunn, W.J.III, see Hansch,e. Ebnother,A., Weber,H.P. 471,494 334,363,366 234,246 Author Index 615

Ebnother, A., see Jucker,E. Elias, H., see McGavack, T. H. Emmrich,J., see Eichenberg,E. 202,211,234,246,247 390,413,416,421,433 416,428 Eckenhoff,J.E., Cooperman, Eliassen,K.A. 115, 123, 124, Endo, K., see Tasaka, K. 59,73 J. H. 578, 597 133, 136-138, 141, 144 Endo, K., see Yamasaki, H. Eckman, P. L., see Brunson, Eliassen,K.A., Reite,O.B. 93,108 J.G. 590,596 137,144 Engelhardt, E. L., Zell, H. c., Ecroli,N., see Chessin,M. Eliel, E. L. 262, 289 Saari, W. S., Christy, M. E., 442,484 Eliel,E. L., Allinger, N. L., Colton,C.D., Stone,C.A., Angyal,S.J., Morrison, Edelson,J., Douglas,J.F., Stavorski,J.M., Wenger,H. G.A. 271,289 Ludwig, B. 1. 536, 555 C., Ludden,C. T. 199,209, Eling, T. E., see Anderson, 543,555 Ederstrom, H. E., Caiman, c., M.W. 547,554 Engelhardt,G., Hahn,G., DiGaugi,M.R. 590-592, Elkins, D., see Leo, A. 280, 454,460,487 597 291,358,367 Edgarian, H., Altura, B. M. Ellenbogen,L., Kelly,R.G., Engelhardt,G., see Friedberg, 585,597 Taylor, R. J., Jr., Stubbs, K. D. 452,488 Edgarian, H., see Altura, B. M. C.S.,Jr. 116,124 Engelman,K., Portnoy,B. 585,595 Ellenbroek, B. W. J. 352, 366 153,172 Edge,N.D., Wragg,W.R. Ellenbroek,B.W.J., Nivard, Engelman,K., Portnoy,B., 197,209 R.J.F., Van Rossum,J.M., Lovenberg, W. 153, 172 Edinburgh Staff 178,209 Ariens, E. J. 352, 366 England, A. c., Schwab, R. S. Edkins,J.S. 41,55 Ellis, C. A., see Villani, F. J. 561,570 Edlbacher, S., Jucker, P., Baur, 200,214,474,503 Engleman,K., see Reichgott, H. 381,428 Ellis,E.F., Oelz,O., Roberts II, M.J. 584,601 Edvinsson,L.,Owman,Ch. L.J., Payne,N.A., Sweet• English.J.P., see Clapp,R.C. 24,27,33 man,B.J., Nies,A.S., Oates, 180, 208, 409, 427 J. A. 460, 486 Ehe, L., see Lippert, T. H. 136, English,J.P., see Vaughan,1.R. Ellis, F. W. 453,486 180,214 146 Ellis,G.P. 175,209 Ehrhart,G., Lindner,E. 215, Ensor, C. R., Russell, D., Chen, Ellis, L. B., see Weiss, S. 2,6-8, G. 232,246 217,246 12,39 Ehrich, W., see Forman,C. Ellis, M., see Johnson, H. L. Epps, L., see Snyder, S. H. 118, 409,429 115,120,125 . 129 Ehrlich, N. J., Kaplan, M. A. Ellman, L., see Wasserman, S. I. Ercan,Z.S., Bokesoy,T.A., 185,209 58,74 Tiirker, R. K. 9, 12, 14, 21, Eichenberg,E., Emmrich,J. Elwin, K., see Dahlquist, R. 34,457-459,487,593,597 416,428 58,70 Ercan,Z.S., Tiirker,R.K. 21, Eichenberger, E., see Emele, J. F., see Tislow, R. 27,34,470,487 Ackermann,H. 446,480 409,436,532,559 Ercoli,N., Schachter,R.J., Eichenberger,E., see Caviezel, Emerson,T.E.,Jr. 576,583, Hueper, W. c., Lewis, M. N. R. 446,484 597 381,409,428,447,487 Eichholtz, E. 382, 405, 428 Emerson,T.E., see Hinshaw, Ercoli,N., Schachter,R.J., Eilbeck,J. F., Smith, W. G. L.B. 18,19,22,34 Leonard,F., Solmssen,U.V. 464,486 Emery,C.J., see Barer,G.R. 387,428 477,481 Einbinder,J.M., see Fox,C.L., Erdos,E.G. 386,428,583,597 Jr. 475,488 Emmelin,N., Kahlson,G.S., Erdos, E. G., see Johnson, A. R. Eisen,S.A., see Sullivan, T.J. Lindstrom, K. 453, 486 60,71 62,63,73 Emmelin,N., Muren,A. 463, Ericson, L., Eriksson, E. 580, Eisenberg,B.C. 199,209 487 581,597 Eisenberg, J., see Straus, B. Emmelin, W., Muren,A. 401, Eriksson,E., see Ericson,L. 564,573 428 580, 581,597 Eisenfeld,A.J., see Phair,J.P. Emmett,J.C. 257,289 Erjavec, F., see Johnson, H. L. 467,499 Emmett,J.C., see Black,J. W. 114,125 Eisman,P.C., see Mayer,R.L. 257,260,262-265,287 Erlanger,J., Gasser,H.S. 582, 439,465,497 Emmett,J.C., see Brimble• 597 combe, R. W. 265, 283, Errard,D.J., see Pascaud,X.B. Elcombe,M.M., Taylor,J.C. 285,288 510,511 266,268,277,289 Emmett,J.c., see Durant,G.J. Errington, M. L., Rochae Silva, Elderfield, R. c., see Titus, E. O. 254, 263, 265, 278, 284--286, M.,Jr. 583,598 521,559 288,289 Erspamer, V., Vitali, T., Elias, H., McGavack,T.H. Emmett, J. C., see Ganellin, Roseghini,M. 133, 145 421,428 C. R. 26, 34, 254, 289 Esch,F., Taubert,M. 369,379 Elias, H., see Harris, R. 416, Emmlin, N., see Anderson, D. J. Eschenhof, E., Rieder,]. 545, 430 390,416,425 556 616 Author Index

Essex,H.E., Wegria,R.G.E., 'Fearn,H.J., Karady,S., West, Feldbush, T. L., Hichens, M. Herrick,J.F., Mann,F.C. G.B. 2,4,34 510,511 13,14,34 Feger,J., see Garbarg,M. 120. Feldhaus,R.A., see Jakschik, Euler, U. S. v. 400,428 124, 568, 571 B.A. 583,584,599 Evans,C., see Burns,J.J. 549. Feher,O., see Went,S. 400,437 Felding,P., see Diamant,B. 551,552,555 Feifel, G., see Lorenz, W. 132, 104,107 Everett, D. H. 329, 330 139,147 Feldman,S., see Gibaldi, M. Everett,G.M., see Roth,L.W. 533,556 Feigen,G.A., Prager,D.J. 457, 381,409,435,450,500 Felmeister,A. 228,246 487 Ewins,A.J. 286,289 Fenton,S. W., see Cope,A.C. Exner, O. 262, 289 Feigen,G.A., see Vurek,G.G. 199,209 Exner,O., see Knobloch,E. 459,503 Ferguson,E.A., see Feinblatt, 229,247 Feigenbaum,J.J.!., see Assem, T.M. 564,570 Eyre,P. 27, 34, 399, 428, 476. E.S.K. 113,123 Ferguson,E. W., see Mielens, 477,487 Feinberg,A.R., see Feinberg, Z.E. 466,473,474,497 Eyre, P., Deline, T. R. 476,487 S. M. 381, 389, 409, 421, Ferguson,J. 328,330 Eyre,P., Lewis,A.J. 6, 16,34, 429,513,556,561,563,570 Ferguson, W. W., see Glenn, 476,487 Feinberg,A.R., see Fried• T.M. 598 Eyre,P., Lewis,A.J., Wells, laender,S. 381, 409, 429, Fernandes,F., see RochaeSilva, P. W. 476,477,487 447,488 M. 302, 314-319, 321, 325, Eyre,P., Wells,P.W. 477,487 Feinberg,A.R., see Rose,J.M. 332,396,435 Eyre,P., seeAlexander,F. 441,450,451,455,500 Ferreira,S. H., Moncada,S., 476,480 Feinberg,S. M. 389, 409, 429, Parsons, M., Vane, J. R. Eyre,P., see Burka,J.F. 440, 439,487 507,511 477, 483, 509,511 Feinberg,S. M., Bernstein, T. B. Ferreira,S. H., see Moncada,S. Eyre,P., see Chand,N. 440, 387,409,429,564,570 506,507,511 444,477,484 Feinberg,S. M., Malkiel,S., Ferullo,C.R., see Kamm,J.J. Eyre,P., see Lewis,A.J. 2, 6, Bernstein, T. B., Hargis, B. J. 533,557 35 389, 429, 441, 442, 447, 451, Filderman,R.B., Kovacs,B.A. Eyre,P., see Wells,P.W. 476, 454,465,487 378,379 503 Feinberg,S. M., Malkiel,S., Filipowski,F., see Hahn,F. Feinberg,A.R. 381, 389, 457,467,491 Fabinyi-Szebehely, M., 409, 421, 429, 513, 556, 561, Filipowski, P., see Bernauer, W. Szebehely,J. 462,487 563,570 463,464,482 Faingold,C.L. 567 Feinberg,S.M., see Bernstein, Filipowski, P., see Bundschu, D. Faingold,C.L., Berry,C.A. T.B. 409,426 463,464,483 561-563, 569,570 Feinberg,S.M., see Fried• Filleux -Blanchard, M. L., Faingold, C. L., Marrazzi,A.S. laender,S. 381, 409, 417, Durand,A. 266,277,289 568,570 421,429,447,488 Filleux -Blanchard, M. L., Fairbrother, P., see Archibald, Feinberg,S.M., see Kempf, Durand-Couturier, A. J.L. 206,207 A.H. 399,431 269,289 Fantozzi,R., Ledda,F., Feinberg,S.M., see Lovejoy, Finch, P., Hitchcock, M. 443, Mannaioni,P.F., Mugelli,A. H. B. 184,211 487 400,401,429 Feinberg,S. M., see Rose,J. M. Fine,J. 575, 581,598 Fantozzi, R., Mannaioni, P. F., 441,450,451,455,500 Fine,J., see Frank,E. 575, 598 Moroni,F. 134,145,440, Feinblatt,H. M. 564,570 Fine,J., see Jacob,S. 589, 590, 487 Feinblatt,T.M., Ferguson,E.A. 592,599 Fantozzi,R., see Ledda,F. 564,570 Fink,M.A. 475,487 10,35,401,431,458,494 Feinstein,R., see Diaz-Guerro, Fink,M.A., Rothlauf,M.V. Fantozzi,R., see Moroni,F. R. 561,570 475,487 458,497 Feinstone, W. H., Williams, Firth,A., Smith, W.G. 466,488 Farmer,J.B., Chick,E.A. 463, R.D., Rubin,B. 180,209, Fisch,H.J., see Lear,E. 566, 487 381,409,429,447,487 571 Farmer,J.B., Richards,I.M., Fekete,M., see Huzsti,Z. 117, Fischel,E.E. 412, 429, 471, 488 Sheard,P., Woods,A.M. 125 Fischel,E.E., see Benacerraf,B. 472,487 Feldberg, W. 13, 17, 22,34 444,471,481 Farrington, G. H., Saravis, C. A., Feldberg,W., Kovacs,B.A. Fischer,H., see Jerchel,D. 181, Cossette,G.R., Miller,D.A., 372, 379 211 Clowes,G.H.A.,Jr. 575, Feldberg, W., Schilf,E. 471, Fischer,L.J., see Hintze,K.L. 598 487 543,557 Farrington,G.H., see Clowes, Feldberg, W., see Archer,R. K. Fischer,L.J., see Wold,J.S. G.H.A.,Jr. 575,597 369, 372, 378 543,560 Fastier,F.N., Reid,C.S.W. Feldberg, W., see Bartosch,R. Fischer,P., see Lecomte,J. 328,330 386,425 462,470,494 Author Index 617

Fish, M.S., Sweeley,C. c., Forrest, W.H., see Teutsch,G. Frey,Ch., see Stoll, W.G. 186, Johnson, N. M., Lawrence, 569,573 213 E. P., Horning,E.C. 521, Forrester, T. E., see Dawson, Fricano,R., see Sperber,N. 556 C.A. 16,33 193,194,213 Fishman,A, see Miller,J. 543, Forshell,G. P., see Gustafsson, Friebel, H. 406,429,465,488 558 A. 132, 145 Friebel,H., Basold,A. 465,488 Fishman, A P., see Pietra,G.G. Foster,L.L., see Medina, M.A. Friebel,H., Flick,H. 463, 465, 26,37 117,127 488 Fishman, V., Goldenberg H. Foulks,J.G.,see Perry,T.L. Friebel,H., Flick,H., Reichle,C. 539,556 133,147 466,488 Fishman, V., see Goldenberg,H. Fourneau,E. 386, 418, 429 Friebel, H., see Schulemann, W. 539,556 Fourneau,E., Bovet,D. 179, 181,213,435 Flacke, W., Atanackovic,D., 209,215,246,386,429 Friedberg,K.D., Engelhardt,G., Gillis,R.A, Alper,M.H. 7, Fournel,J., see Bovet,J. 412, Meineke,F. 452, 488 8,11-15,21,34,400,429 424,426 Friedberg,K.D., Garbe,G., Flataker,L., see Winter,C.A. Fowle,A.S., see Peck,A.W. Grlitzmacher,1. 464,488 464,503, 562,573 569,572 Fleckenstein, A., Hardt,A. 419, Fox,C. L.,Jr., Einbinder,J. M., Friedlaender,A.S., Friedlaen• 420,429,443,488 Nelson,C.T. 475, 488 der,S. 381, 386,429, 447, Fleisch,J.H., see Maling,H.M. Fox, L.A., see Brown,E.A. 488 27,36 185,208 Friedlaender,S., Feinberg,S. M. Fleming,R. W., Rieveschl,G.,Jr. Fraile,A., Casas, F., Alonso,M. 417,421,429 519,556 138,145 Friedlaender,S., Feinberg,S. M., Flick, H., see Friebel,H. 463, Fram,D.H., Green,J.P. 131, Feinberg,AR. 381, 409, 465,466,488 133, 140, 145 429,447,488 Flock,E.V., see Navert,H. Fram,D.H., see Green,J.P. Friedlaender,S., see Friedlaen• 133,147 140, 141,145 der,A.S. 381,386,429,447, Flynn,J. T., Appert, H. E., Francis, D., see Yamamoto,S. 488 Howard,J.M. 584, 598 478,504 Friedlaender,S., see Rose,J.M. Flynn,S. B., Owen,D.A.A. Francis, L. E. 369 441,450,451,455,500 477,488 Francis, L. E., Melville, K.1. Friedman,E.W., see Jacob,S. Forster, W., Mentz, P. 460,488 369,371,374,379 589,590,592,599 Fohlen, G. M., see Kumler, W. D. Francis, L. E., Melville, K.I., Friedman, H. J., see Cohen, M. B. 259,266,268,291 Douglas,D.E. 370,379, 421,427 Folkow,B., Haeger,K., 455,488 Friedman,H.L., Tolstoouhov, Kahlson,G. 183, 209, Francis, L. E., see Lefcort, M. A V. 180,209 252,289 373-375,378,380 Frimmer, M. 423,429 Folli,G., see Melli,G. 456,497 Francis, L. E., see Stotland, M. 370,373,374,378,380 Frimmer,M., Mliller,F.W. Fonkalsryd,E. W., see Rangel, 422,423,429 D. M. 575,601 Frank,D.E. 463,488 Frisk-Holmberg,M. 442,488 Fordtran,J.S., see Richardson, Frank,E., Fine,I., Pillemer,L. 575,598 Frisk-Holmberg,M .. Uvniis,B. C.T. 265,292 78,90 Foreman, 1. c., Garland, L. G. Frank,H.A., see Jacob,S. 589, 65-{i7,70 590, 592, 599 Fromm,S., Wilson,R.F. 578, Franke,F.R., see Cohen,S.G. 598 Foreman,J.c., Mongar,J.L. 470,485 Fucks, A M., see McGavack, T. 58, 63, 65, 70 Franks,F.M., see Ison,R.R. H. 183,211 Foreman,J.C., Mongar,J.L., 180, 188, 190, 193, 194, 203, Fujita, T. 459,488 Gomperts,B.D. 65,70 210,218, 226,236-238,240, Fujita,T., Iwasa,J., Hansch,C. Foreman,J.c., Mongar,J.L., 247,312,331,387,388,398, 216,246 Gomperts,B.D., Garland, 430 L.G. 64,65,70 Fujita, T., see Hansch,C. 216, Fransway,R.L., see Glazko, 231,240,247 Foreman,J.c., see Mongar,J.L. AJ. 519,556 Fukao,T., see Takagi,K. 475, 65, 72 Fredholm,B. 98,107 502 Forest,J., see Boissier,J.R. Free, C. A., Majchrowicz, E., Fukuda,T. 575,598 204,208 Hess,S.M. 116,124 Fukuda,T., Kobayashi,T., Forman,c., Mertens,E., Graub, Free,S.M., Wilson,1.W. 231, Okada, M. 575, 598 M., Ehrich, W. 409,429 246 Funayama 300, 404 Forney,R.G., see Hughes,F.W. Fregnan,G.B., Suchowsky, Funayama, see Antonio,A. 562,571 G.K. 475,488 312 Forrest,J.A.H., see Carter,D.C. Fregnan,G.B., Gliisser,A. H. Funcke,A. B. H., Louwerse, W. 265,288 475,488 J., Tersteege,H.M., Harms, Forrest,W.H., see Brown,C.R. French,L.A, see Allen,G.S. A.F., Nauta,W.Th. 547, 561, 563, 566, 570 27,30 556 618 Author Index

Funcke,A. B. H., Mulder, D., Ganellin, C. R., see Parsons, Geissman, T. A., see Dejonge, M. c., Tersteege, H. M. E. 257, 292 Crescitelli,F. 417, 427 M., Harms,A. F., Nauta, W. Ganley,O.H. 447,474,488 Geissman,T.A., see Wein• Th. 201,209 Ganter,G., Schretzenmayr,A. mann,E.O. 524--526,559 Funcke,A.B.H., see Bijlsma,U. 18, 19,34 Gelvin, E. P., McGavack. T. H. G. 183,208 Garbarg,M., Barbin, G., Feger, 513,516,556 Furchgott,R.F. 1,27,34,299, J., Schwartz,J.-c. 120, 124, Genazzani,E., see Abbozo,G. 324,328,330,397,429 568,571 562,570 Furchgott,R.F., Bursztyn,P. Garbarg, M., Halpern, B. 113, Gennis,J., see Straus,B. 564, 324,328,330 124 573 Furchgott,R. F., Jurkiewicz,A., Garbe,G., see Friedberg,K.D. Gerald, M. c., Maickel, R. P. Jurkiewicz,N.H. 328,331 464,488 562,571 Furchgott,R.F., see Shorr,E. Garcia,X., see Gerald, M. C., Sethi, o. P., Muhi• 575,602 Alonso-de-Florida, F. Eldeen,Z., Mahishi,N., Furukawa,T. 24,25,34 456,480 Witiak,D.T. 204,209 Fuxe, K., see Lidbrink, P. 567, Garcia-Arocha,H. 78,90,471, Gerald,M.C., see Witiak,D.T. 571 472,488 204,214 Garcia Leme,J., Rocha e Silva, Gerant,M., see Lorenz, W. M. 303,331 111, 119, 126 Gaddum,J.H. 429 Garcia Leme,J., see Lette, M. P. Gershon,M.D., Ross,L.L. Gaddum,J.H., see Barsonum, 478,495 474,475,489 G.S. 370, 379, 586, 587, Garcia Leme,J., see Rocha e Gfeller,E., see Taylor,K.M. 596 Silva, M. 303,332,386,422, 169,173 Gaertner,H.J., Breyer, U. 529, 423,435,507,511 Ghosh,M.N., Schild,H.O. 530,538,556 Garden,J. W. 143,145 254,289 Gaertner,H.J., Breyer, U, Lio• Gardiner,P.J., see Butt,A.A. Gibaldi,M., Feldman,S. 533, min,G. 529, 530, 538, 556 510,511 556 Gaertner,H.J., see Breyer, U. Gardocki,J.F., see P'An,S. Y. Gibson, K. D., Hirschowitz, 530,554 185,212,388,433 B.L, Hutchison,G. 264, Gaillot, P., see Charpentier, P. Garland,L.G., Mongar,J.L. 289 197,208 64, 70 Gibson,K.D., Scheraga, Galambos,A. 563,570 Garland,L.G., see Foreman, H.A. 289 Galant,S. P., Bullock,J., Wong, J. C. 64--67, 70 Gibson,R., Hirschowitz,B. I., D., Malbach,H.I. 421,429 Gasser,H.S., see Erlanger,J. Hutchisin, G. 49, 53, 54,55 Galant,S. P., Zippin,C., Bullock, 582,597 Gibson, R., see Hirschowitz, J., Crisp,J. 421,430 Gastel,R., see Conney,A.H. B.1. 264,290 Galindo,A., Krnjevic, K., 549,552,555 Giertz, H., Bernauer, W., Hahn, Schwartz,S. 568,570 Gastpar,H., Lorenz, W. 111, F., Schmutzler, W. 468, 489 Galvin,M.J.Jr., Bunce,R., 124 Reichard,S. M. 112, 124 Gattegno, D., Giuliani,A. M., Giertz,H., Glanzmann,c., Keller,R. 471, 472, 489 Ganellin,C.R. 257, 262, 271, Bossa,M., Ramunni,G. Giertz,H., Hahn,F. 443, 444, 289,401,417 279,289 448, 451, 452, 463, 466, 468, Ganellin,C.R., Durant,G.J., Gaudechon,J., see Charpentier, 489 Emmett,J.C. 26, 34, 254, P. 197,208 289 Gauthier, P., Delagrave,J., Giertz,H., Hahn,F., Jurna,l., Ganellin,C.R., Port,G.N.J., Laflamme, G., Pelletier, G. Lange, A. 468, 489 Richards, W.G. 279,289 370,379 Giertz,H., Hahn,F., Jurna,l., Ganellin,C.R., see Black,J. W. Gautieri,R.F., see Ciuchta, Schmutzler, W. 441, 445, 3, 5, 12, 24, 32, 49, 50, 55, H.P. 20,33 448, 452, 489 252, 257, 259, 260, 262-265, Gay,L.N., Carliner,P.E. 183, Giertz,H., Hahn,F., Krull,P., 281, 287, 376, 379, 386, 392, 209 Albert, U. 444,489 393, 401, 421, 426, 440, 458, Gay,L.N., see Landau,S.W. Giertz,H., Hahn,F., Opferkuch, 482. 569,570 399,406, 409, 417, 418, 431, W., Schmutzler, W. 453, Ganellin,C.R., see Brimble• 441--443, 448, 451, 455, 463, 454,489 combe,R. W. 265,283,285, 465,467,494 Giertz,H., Hahn, F., Schmutzler, 288 Gazzaniga,A.B., O'Connor, W. 489 Ganellin,C.R., see Critchley, N.E. 575,598 Giertz, H., Hahn, F., Schmutzler, S.R. 271,273,288 Gebauer-Fuelnegg,E., see W., Kollmeier,J. 441, 452, Ganellin,C.R., see Durant,G.J. Dragstedt,C.A. 386, 428 468,489 254, 256, 263, 265, 278, Geesing,H., see Lorenz, W. Giertz,H., Hahn,F., Seseke,G., 284--286,288,289 143,147 Schmutzler, W. 466, 472, Ganellin,C.R., see Kamenar,B. Geiger, W.B., Alpers,H.S. 489 271,290 455,488 Giertz, H., Krako, K. 468, 489 Author Index 619

Giertz, H., Mitze, U. 453, 464, Glassco, E. M., see Winder, Goldner, M., Bouthillier, L. P. 489 e.V. 183, 214, 390, 409, 444,489 Giertz,H., see Bernauer, W. 413,416,437 Goldschmidt, 0., see Schmutz• 134, 144, 452, 461, 482, 590, Glazko,A.J., Dill, W.A. 514, ler,W. 444,501 591,596 516--519,556 Goldstein, L., Murphree, H. B., Giertz,H., see Hahn,F. 444, Glazko,A.J., Dill, W.A., Frans• Pfeiffer, e. e. 562, 563, 565, 445,452-454,490,491 way,R.L. 519, 556 566,571 Giertz,H., see Kretzschmar,R. Glazko,A.J., McGinty,D.A., Goldstein, L., Pfeiffer, e. e., 468,493 Dill,W.A., Wilson,M.L., Munoz,e. 568,571 Giessler,A.J., see Bekemeier, Ward,e.S. 514, 518-520, Goldstone,l., see Hutchins, P. H. 506,511 556 Gij6n, E., see Glazko,A.J., see Dill, W.A. M. 580, 581, 599 Alonso-de-Florida, F. 514,518,520,534,555 Gomperts,B.D., see Foreman,J. 456,480 Glenn, T. M., Lefer,A. M. 575, e. 64,65,70 Gilbert,H.S., Warner,R.R. P., 598 Gonzalez, e. e., see Alonso-de• Wasserman, L. R. 142, 145 Glenn, T. M., Lefer,A. M., Florida,F. 456, 480 Gilbert,H.S., see Krauss,S. Beardsley,A.e., Ferguson, Gonzalez,R.R., Jr., Bond,R.F. 110, 126 W. W., Lopez-Rasi,A. M., 581,598 Gilbert,R.P., see Young,R.H. Serate,T.S., Morris,J.R., Good, R. A., see Campbell, B. 453,504 Wangensteen, S. L. 598 445,470,484 Gilbert, V. E., Braude, A. I. Glick, D., see Kim, Y. S. 112, Goodfriend, L., see Kovacs, B. A. 575,598 126 374, 377, 379 Gilbertson, E., see Grennan, Glick, D., see Sondergaard,1. Goodfriend,L., see WakkarY,J. D. M. 506, 511 112,129 A. 378,380 Gilbrand, B., see Granerus, Glotzer, P., see Jacob,s. 589, Goodman,F.R., see Weiss,G.B. 590,592,599 G. 139,145 65,74 Gilfoil,T., see Marrazzi,A.S. Glover,W.E., Carroll,P.R., Goose,l., Blair,A.M. 64,70, 568,572 l.a tt. N. 440, 470, 489 473,489 Gillespie, E. 70 Glover. W. E., see Carroll, P. R. 64, Gordon,D., see Hanahoe,T.H. Gillespie, E., Levine, R. J., 11, 33, 470,484 P. 64,71 Malawista,S. E. 59, 63, 70 Glover, W. E., see Chipman, P. Gordon, L. E., Ruffin, e. L. 566, 440,485 Gillespie, E., Lichtenstein, 571 L. M. 59, 63, 70 Glowinski,J., see Snyder,S.H. Gorsuch,T.T. 152,172 133, 149 Gillespie, E., see Lichtenstein, Gosselin, R. E. 328,331 L.M. 440,495 Goadby, P., Phillips,E.A. 15, Gossow,U., see Bernauer,W. Gillette,J. R. 521,556 21,34 462,463,482 Goadby,P., Smith,W.G. 464, Gillette, J. R., see Brodie, B. B. Gossow, U., see Hahn,F. 457, 489 549,554 467,491 Gobert,J.G., see Close,J.A. Gilliam,D.R., see Wrenn,T.R. Goth,A. 57,58,63,70,78,90 530,531,555 137,150 Goth,A., Adams,H. R., Knoo• Goddard, L., see l.itchfield, 1. T., Gillis,R.A., see Flacke, W. huizen, M. 63, 100, Jr. 386, 409, 432, 441, 465, 70, 107 7, 8, 11-15,21,34,400,429 Goth,A., Johnson,A.R. 57, 70 496 Gilmore, V., see Majno,G. Goth,A., see Chakravarty,N. Goetzl,E.J., Wasserman,S. I., 423,432 63,69 Austen,K.F. 378,379 Giotti,A., see Buffoni,F. 9, 10, Goth, A., see Copenhaver,1. H., 32 Goetzl,E.J., see Wasserman,S. Jr. 469,470,485 Girard,J.P. 199,209 I. 58, 74,78,92 Goth,A., see Isaac,L. 462,493 Giri,S.N., see Devereux,D.F. Gold, W. M., see Chiesa,A. Gottlieb,I.S., see Diaz-Guerro, 586,587,597 469,484 R. 561,570 Giroud,J.P., see Di Rosa,M. Goldacre,R., see Albert,A. Gough,E.D., see Dyer,D.e. 507,508,511 267,287 27,33 Giuliani,A. M., see Gattegno,D. Goldberg, H., see Wiggers, H. e. Gould,R.F. 216,246,334,366 279,289 578,602 Govier, W. M., see Roszkowski, Goldenberg, H., Fishman, V. A.P. 184,212,234,249 Gladys, e. L., see Blackwood, 539,556 1.E. 268,287 Govier, W.M., see Roth,F.E. Goldenberg, H., see Fishman, V. 194,212,234,249.388,404, GHisser, A. H., see Fregnan,G.B. 539,556 435,500 475,488 Goldfeder,A., see l.erman,S. Grabar, P., see Halpern, B. N. Glanzmann, e., see Giertz, H. 409,431 442, 491 471, 472, 489 Goldman, B., Aledort, L. M., Graham,I.D.P. 387,417,430 Glanzmann,e., see Hahn,F. Pustkin,E., Burrows,L. Graham,I.D.P., AI Katib,H. 457,467,491 543,556 322,331 Glasock, R. J., see Moore, T. e. Goldman, I. M., see Bloom, B. M. Graham,J.D.P., Lewis,G.P. 143,147 256,288,329,330 390,430 620 Author Index

Graham,J.D.P., see Dews,P.B. Greaves, M. W., McDonald• Grossman, M.I., see Adashek, D. 9,12,14,21,33,252,288,400, Gibson, W. 506,511 46,47,55 419,428 Greaves, M. W., see Yamamoto, Grossman, M. I., see Johnson, L. Graham, P., Kahlson, G., Rosen• S. 478,504 R. 47,50,55 gren,E. 110, 124 Greeff,K., Benfey,B.G., Bokel• Grossman, M.I., see Robertson, Graham,P., Schild,H.O. 110, mann,A. 457,490 e. 252, 253, 292, 293 124 Greeff,K., Bokelmann,A. 457, Grover,R.F., see Tucker,A. 5, Graham, R. C., see Ebert, R. H. 459,490 15,21,38,469,502 24,33 Greeff,K., Heeg,E. 457,490 Groves, W.G., see Ridley, P.T. Grahn,B. 111,124 Greeff,K., see Senger,M. 458, 265,292 Grahn,B., Henningsson,S.S.G., 459,501 Gruber, V.F. 576,598 Kahlson, G., Rosengren, E. Green,A.F. 190,209,445,448, Gruber,V.F., see Porter,e.e. 119,124 451,455,490 543,544,558 Grahn, B., Hughes, R., Kahlson, Green,A. F., see Adamson, D. W. Griinspan, M. 445, 452, 490 G., Rosengren,E. 111,124 190,192,207 Griinspan, M., see Cirstea, M. Grahn,B., Rosengren,E. 113, Green,A.F., see White,A.e. 469,485 124 189,214,226,249 Griitzmacher,J., see Friedberg, Grana, A. 468,489 Green, D. M., see Brimblecombe, K. D. 464, 488 Grana,A., Recarte, P. 467,489 R. W. 178, 208 Grund,E.R., see Thompson,M. Grana,R., see Rocha e Silva,M. Green,H.N., Stoner,H.B. 576, H. 265,293 586, 588, 601 598 Grund,V.R., see Hanna,P.E. Grandage,A., see Tislow,R. Green,1. P. 122,124 204,206,210 409,436,532,559 Green,J.P., Fram,D.H., Kase, Grunwald,E., see Ralph,E.K. Granerus,G. 140, 141, 145 N. 140, 141, 145 260,292 Granerus, G., Gilbrand, B., Green,J.P., see Fram,D.H. Gunn,J.A. 14,21,34 Wetterqvist,H. 139, 145 131, 133, 140,145 Gunnar,R.M., Weeks,R.E. Granerus,G., Lindell,S.E., Greenberg,S., see Bohr,D.F. 591,593,598 Waldenstrom, J., Westling, 29,32 Gupta,M.B., Bhalla,T.N., H., White,T. 141, 143, 145 Greene, W.e., see Sullivan, T.J. Tangri, K. K. 462,490 Granerus, G., Magnusson, R. 58,61,73 Gurd,F.N., see Bounos,G. 131,145 Greenfield, A. D. M., see Duff, F. 575,596 Granerus,G., Svensson,S.E., 19,33 Gururaj, V.J., see Russo,R. M. Wetterqvist,H., White,T. Grega,G.J., see Haddy,F.G. 569,572 142, 145 26,34 Guschin,I.S., Orlow,S.M., Granerus, G., Wetterqvist,H. Gregory,R.A., Tracy,H.J. 42, Czju,N.L. 79,90 135,136 55 Guschin,I.S., Vvniis,B. 79,90 Granerus, G., Wetterqvist, H., Greig,M.E., see Hanze,A.R. Gustafsson,A., Forshell,G. P. White,T. 131,140,141,145 202,210 132,145 Granerus,G., see Agrup,P. Grennan,D.M., Rooney,P.J., Guth,P.H., Smith,E. 421,430 142, 143 Gilbertson,E., Dick,W.C. Guthrie,P.D., see Johnson, L. R. Granerus,G., see Berg,B. 115, 506,511 45,55 123,140,142,143,144 Griessen,M., see Perrier,e. V. Guyton, A. e., Crowell, J. W. Granerus,G, see Bergmark,J. 458,499 582,598 139, 144 Griffith,R., see Weidmann,H. Gwilliam,J. M., see Orr, T.S.G. Granerus,G., see Jonassen,F. 523,559 64, 72 141,146 Griffith,R.K., see Witiak,D.T. Syure,L., see Hershey,S.G. Granerus,G., see Lowhagen,O. 204,214 577,599 142,147 Griffiths,1. 582, 585-587,598 Granerus, G., see Norinder,B. Grimley,P.M., see Sullivan,A.L. Haas,H. 215, 217, 246, 387, 143,147 61,73 388,409,415,421,422,430, Granerus,G., see Westin,1. Grivsky,E., see Morren,H. 444,453,455,490,568,571 142,/49 185,212 Haas, H. L., Anderson, E. G., Grant,R.T., see Lewis,T. 420, Grodins,F.S., see McNamee,1. H osH, L. 568, 571 432 E. 26,27,36 Haberer,e., see Noell,W.K. Grassmann, W., see Staub, H. Groot,W.M. de, see Ariens,E.J. 564-567,572 14,21,38 333,366 Hach, V., see Protiva, M. 201, Graub,M., see Forman,e. 409, Gross, F., Haefeli,H. 462, 490 212 429 Grossman, M.1. 42, 43, 55 Hackel,D.B., see Winternitz, W. Grauwiler,J., see Weidmann,H. Grossman, M.I., Konturek, S. J. W. 471,503 523,559 49-53,55,264,289 Haddy,F.J. 18,22,34 Graves,A., see Posner,H.S. Grossman, M .1., Robertson, e. Haddy,F.J., Scott,J.B. 23, 34, 529,558 R.,Ivy,A.C. 42,55 581,598 Gray,L., see Kaplan,A.P. 164, Grossman, M.I., Robertson, C., Haddy,F.J., Scott,J. B., Grega, 172 Rosiere,e.E. 252, 253,289 G.J. 26,34 Author Index 621

Haefeli,H., see Gross,F. 462, Hakanson,R. 110-112, 124 Halpern, B. N., Liacopoulos, P. 490 Hakanson,R., Hedenbro,J., Liacopoulos-Briot,M. 422, Hafelinger,G. 268,289 Liedberg, G., Rehfeld,1. F., 430,467,473,491 Hafliger,F., see Schindler, W. Stadil,P. 444,491 Halpern,B.N., Liacopoulos,P., 201,213 Hakanson, R., Lied berg, G. 44, Perez del Castillo, C. 471, Hafner,G., see Lorenz, W. 143, 55, 112, 124 473,491 147 Hakanson,R., Liedberg,G., Halpern,B.N., Mauric,G. 251, Haeger, K., see Folkow,B. 183, Oscarson,]. 45,55 290 209,252,289 Haegermark,O., see Bloom,G. Hakanson, R., Lilja, B., Owman, Halpern, B. N., Neveu, T., Spec• C. 111, 112, 124 tor,S. 475,491 D. 59,69,79,89,90 Hagedorn, M., Bernauer, W., Hakanson,R.,Owman,C. 112, Halpern,B.N., Perrin,G., Dews, Mittermayer,Ch. 461,490 124 P. B. 417,430 Hagedorn, M., see Bernauer, W. Hakanson,R., Owman, c., Halpern, B. N., Roux,1. 444, 463,464,482 Sjoberg,N.-O. 124 491 Hagan,E., see Lehmann,G. Hakanson,R., see Aures,D. Halpern,B.N., Stiefel,C., 203,211, 388, 413, 431 111, 112, 123 Liacopoulos-Briot, M., Co• Hahn,F. 398, 399, 412, 444, Hakanson,R., see Bjorklund,A. novici, L. 185,209,448,491 452,460,461,490 121,123 Halpern,B. N., Trolliet,J., Mar• Hahn, F., Bernauer, W. 456, Hakanson,R., see Johnson,L.R. tin,1. 471,491 457-461,490 43-45,56 Halpern,B. N., Walthert,F. Hahn,F., Bernauer, W., Mahl• Halbach,S., see Lorenz, W. 180,210 stedt,J., Resch-·Bollhagen,S., 111,126 Halpern, B. N., see Liacopoulos, Beck,E. 461, 462, 490 Hald,J. 513,514,518,556 P. 443,467,495 Hahn,F., Ebner,C., Giertz,H. Halevy 23 Halpern, B. N., see Pasteur 452,490 Halevy,S., Altura,B. M. 584, Vallery-Radot, P. 442, 470, Hahn,F., Giertz,H., Schmutzler, 592, 593, 598 499 W. 445,453,454,490 Haley, T.J., Andem, M.R. 121, Hahn,F., Jobke,A. 468,490 124 Halpern,B.N., see Vallery-Ra• Hahn,F., Kretzschmar,R., Haley,T.J., Harris,D.H. 121, dot, P. 389, 409, 421,436 Teschendorf,H.J., Mitze,R. 125 Ham,A. L., see Augstein, J. 203, 445,454,468,472,490 Hall,D.E., see Orr,T.S.G. 59, 207 Hahn,F., Miilke,G., Schmitz- 64,72 Ham,E.A., Schayer,R.W. 131, Bocklenberg,G. 471,490 Hall,L. W., see Parish, W.E. 145 Hahn, F., Oberdorf,A. 468,490 452,498 Ham,N.S. 182,210 Hahn,F., Plester,D., Schild, W. Hall,N.F.,Sprinkle,M.R. 256, Ham,N.S., Casy,A.F., Ison,R. 448,490 290 R. 182,210 Hahn,F., Priihle,F., Mitze,R., Hallenbeck,G.A., see Code,C.F. Hamburger,1., see Halpern, B. N. Degand,L. 441,490 50,55 389,409,430 Hahn, F., Schmutzler, W., Halloran,L.G., Swank,M., Hamburger,1., see Vallery-Ra• Seseke,G., Giertz,H., Ber• Haynes, B. W. 265, 290 dot, P. 409,436 nauer, W. 444,491 Halmagyi,D.F.J., Starzecki,B., Hahn,F., Somorjai,K., Mitze,R.. Hamelmann, H., see Lorenz, W. Horner,G.J. 16,21,34 143, 147 Halpern, B., see Garbarg, M. Zahradnik,H. P. 445,448, Hamelmann, H., see Thermann, 113,124 451,460,461,463,490 M. 2,3,5,7,8,15,17,21,38 Halpern, B. N. 15,21,34, 179, Hahn,F., Teschendorf,H.J., Hamilton,L.H., see Dawson,C. 196,209,271,227,247, Kretzschmar,R., Gossow, U., A. 16,33 381, 387, 389, 399, 405, 406, Glanzmann,c., Filipowski, Hamilton, W.F., see Remington, 409,413,417,422,430, F., Somorjai, K. 457, 467, J. W. 578,601 439, 441, 443-445, 448, 451, 491 Hamilton, W. F., Jr., see Reming- 453, 455, 465, 468, 469, 491, Hahn, F., see Bernauer,W. 134, ton,J.W. 578,601 589-591,598 144, 442, 452, 457-459, Hammersen, F. 26,34 461-464, 472, 482, 590, 591, Halpern, B. N., Cruchaud, S. Hammett, L. P. 355, 366 596 444,491 Hampson,L.G., see Bounos,G. Hahn,F., see Buchholz,R. 462, Halpern,B. N., Cruchaud,S., 575,596 483 Vermeil,G., Roux,J.-L. Hampson, P., Mathias,A. 268, Hahn,F., see Giertz,H. 441, 444,491 290 443-445,448,451-454,466, Halpern,B.N., Ducrot,R. 196, Hanahoe, T. H. P., Holliman,A., 468,472,489 197,209, 381, 389, 409, 430, Gordon,D., Wieczorek, W. Hahn,F., see Joiner, P. D. 454, 537,556 64,71 455,493 Halpern,B. N., Grabar, P., Handford,S. W., see Chinn, H.1. Hahn,G., see Engelhardt,G. Perrin, G. 442,491 411, 427 454,460,487 Halpern,B.N., Hamburger,1. Hanna, P. E., Ahmed,A. E. 206, Hahn,H. 439 389,409,430 210,240,247 622 Author Index

Hanna,P.E., Ahmed,A.E., Harkins,1. L., Praagh, 1. G. van, Hayashi, H., Yoshinaga, M., Grund, V. R., Merriman, R. L. Irwin, N. T. 566, 571 Koono, M., Miyoshi, H., 204,210 Harmer, I. M., Harris, K. E. 6, Matsumura,M. 471,492 Hanna,P.E., Borchardt,R.T. 7,34 Hayashi,M., see Pierce,L. 262, 205,210,240,247 Harms,A. F. 232,236,247 292 Hanna,P.E., Grund,V.R., Harms,A.F., Hespe,W., Nauta, Haynes,B.W., see Halloran,L. Anders,M. W. 206,210 W. Th., Rekker, R. F., Tim• G. 265,290 Hansch,C. 334, 360, 366 merman,H., De Vries,]. Hays,H. W., see Rennick,B. Hansch, c., Anderson, S. M. 215-217, 219-222, 224, 227, 453,500 262,290 229, 236, 242, 244, 245, 247, Hays,H.W., see Yonkman,F.F. Hansch,C., Clayton,]. M. 334, 387,430 409,437,469,504,591,602 363,366 Harms,A.F., Nauta, W.Th., Hays,J.T., see Niemann,c. Hansch, c., Dunn, W. 1. III 232, 236,247 256,292 334,363,366 Harms,A.F., Nys,G.G. 217 Hazen,E.E., see Cotton,F.A. Hansch, c., Fujita, T. 216, 240, Harms,A. F., see Bijlsma, U. G. 257,288 247 183,208 Head, K. W., see Alexander, F. Hansch,C., Leo,A., Unger,S. H., Harms,A. F., see Funcke,A. B. H. 476,480 Kim,K.H., Nikaitani, D., 201,209,547,556 Heading, R. c., see Carter,D.C. Lien,E.J. 334,358,366 Harms,A. F., see Nauta, W. Th. 265,288 Hansch,C., Lien,E.1. 334,362, 227, 248, 256, 292, 402, 404, Hecht,H.H., see Anderson,F.L. 366 419,433 5,15,17,31 Hansch, c., Maloney, P. P., Harms,A. F., see Rekker,R. F. Hedenbro,]., see Hakanson,R. Fujita, T., Muir,R. M. 216, 183,212,234,236,248 444,491 387, 388, 390, 402, 413-416, 231,240,247 Hedges,A., Hills,M., Maclay, W. 434 Hansch, c., Quinlan,]. E., Law• P., Newman-Taylor,A.1. Harms,A.F., see Van der SteIt,C rence, G. I. 262, Turner, P. 566,571 290 199,200,214 Hedqvist, P., see Mathe,A. A. Hansch,C., see Fujita, T. 216, Harpootlian,H., see Buhler,D. 443,496 246 R. 536,537,555 Hansch,C., see Kutter,E. 177, Harris,D., Smy,].R., Reed,J.D., Heeg,E., see GreeiT, K. 457,490 211,216,232,247,362,366 Venables,C. W. 264, 290 Heese, H. V., see Harrison, V. C. Hansch, c., see Leo, A. 280, Harris, D. H., see Haley, T. 1. 141,145 291,358,367 121, 125 Heifer,M.H., see Vick,1.A. 60, Hansen,N., see Yonkman,F.F. Harris, D. W., see Reed,]. D. 74,585-587,602 417,437,462,504 21,37, 49, 50, 53, 56 Heinrich, M.A. 562, 563,571 Hansen,S., see Perry, T. L. 133, Harris,J.M., Spencer,P.S.J. Heintz,R., Losse,H. 471,492 147 378,379 Heisler,A., see McGavack,T.H. Hansson, E., Schmiterlow, C. G. Harris, K. E., see Harmer,1. M. 513,516,518,523,524,558 197,210,538,539,556 6,7,34 Heisler,S., see Kovacs,E. M. Hansson,E., see Aures,D. 110, Harris, M., see Kim, K. S. 132, 133,146 123 146 Heitland,St., see Lorenz, W. Hansson,R. 134, 139, 145 Harris,P.N., see Lee,H.M. 139,147 Hansson,R., Holmberg,C.G., 187,211,448,465,495 Helander, C. G., Lindell, S.-E., Tibbling,G., Tryding,N., Harris,R., McGavack,T.H., Westling,H. 139,145 Westling, H., Wetterqvist, H. Elias,H. 416,430 Helander,H.F., Bloom,G.D. 134,145 Harrison, V. c., Peat, G., Heese, 75,90 Hanze,A.R., Strube,R.E., H.V. 141,145 Hellem,A.M., see Murer,E.H. Greig,M.E. 202,210 Hart,E., see Marrazzi,A.S. 68, 72 Harada, M., Takeuchi, M., 568,572 Heller,F.F., see Bain,W.A. Katagiri,K. 467, 473, 475, Harwood,D., see Dreyer,N.B. 421,425 491 409,428 Hemmi,H., see Meyer,K.H. Harclois,R., see Bovet,D. 180, Hashimoto,E., ThaI, P. 575, 215,247 208 598 Henderson,A.R., see Judd,A.R. Hardaway,R.N.III. 578,579, Hashimoto, H. 7, 8, 11, 34 180,211 598 Hass,H., Saltz,N.J. 575,599 Henderson,F.G., see Lin,T.M. Hardman, H. F., see Dage, R. C. Hawkins,D.F. 122, 125, 398, 252, 253, 291 256,288 430,442,454,491 Henderson,]. F., see Mazel, P. Hardt,A., see Fleckenstein,A. Hawkins,D.F., Rosa,L.M. 527,558 419,420,429,443,488 455,491 Henderson, L. M., see Allen, G. S. Hcugis,B.J., scc Feinberg,S.M. Hawkins,D.F., Schild,H.O. 27,30 389,429,441,442,447,451, 218,247,251,290,442,491 Henney,c., see Lichtenstein,L. 454,465,487 Hawkins,D.F., see Schild,H.O. M. 440,495 Hargis, B. 1., see Malkiel, S. 398,435,454,501 Henningsson,S.S.G., Lundell, 474,496 Hawkins,J. D. 492 L., Rosengren,E. 112,125 Author Index 623

Henningsson,S.S.G., Rosen• Hespe, W., Prins, H., Kafoe, W. Hirt,R.e., Schmitt,R.G., gren,E. 119, 125, 135, 138, F., Nauta, W. Th. 547, 557 Strauss,H.L., Koren,].G. 145 Hespe, W., see Harms,A. F. 266,290 Henningsson, S. S. G., see Grahn, 215-217, 219-222, 224, 227, Hitchcock, M., Schneider, M. W. B. 119, 124 229, 236, 242, 244, 245, 247, 58,71 Henry, D., see Coyle,J. T. 153, 387,430 Hitchcock, M., see Finch, P. 171 Hespe, W., see Roozemond,R.e. 443,487 548,558 Henson,E.e., see Izard,S.R. Hite, G., see Barouh, V. 184, 463,493 Hess,S.M., see Free,e.A. 116, 207 124 Henson,P.M., see Becker,E.L. Hite, G., see Shafi'ee, A. 184, Hesselbo,T. 57,60,64,67,68,69 280,281,290,552, 553, 554, 557 195,213,236,249 Henson, P. M., see Morrison, D. Hesselbo,T., see Black,J. W. Hjaltason,S., see Arborelius, M. e. 59,72 263-265,287 16,21,32 Herblot,M., see Sigal,B. 200, Hesselbo, T., see Wyllie,]. H. Hobbs,D.e. 546,557 213 50,56,259,265,281,293 Hobbs,R. D., see Trendelenburg, Herbst,H., see Schenker,E. Hester,H.R., see Code,e.F. U. 457,502 176, 197, 198,213 585,586,588,597 Hochrein,M., Meier,R. 13,18, Herlem, M. 266,267,290 Heus, W. J., see Stelt, e. van der 34 Herman,A.G., see Collier,J.G. 234, 236,249 Hogberg, B., see Chakravarty, N. 584,597 Hewick,D.S., see Beckett,A.H. 93,107 Hermann, H., Cier,J.F., Paulet, 539,554 Horlein, U. 204,210 G. 469, 492, 589, 590, 599 Hichens, M., see Feldbush, T. L. Hoffer,B.J., see Siggins,G.R. Hermreck,A. S., Thal,A. P. 510,511 568,572 579,599 Hicks,R. 464,492 Hoffman,E.A., see Tucker,A. Herrick,J.F., see Essex,H.E. Hicks, R., Sackeyfio, A. e. 463, 469,502 464,492 13, 14,34 Hoffmann, K., see Schmid, H. J. Herriott,H.J., see Landau,S.W. Hightower, N. e., see Code, e. F. 202,213 50, 55 406,409,431 Hoffmaster, T., see Macht, D. I. Hill,]. H., Martin, L. 445, 492 Herrold,E., see Craver,B. N. 562,572 Hill,S.R. Jr., see Vroom,F.Q. 447, 462,486 Hoggenstraaten, W., see Ver• 543, 559 Hershey,S.G., Altura,B.M. loop,A. 363,367 577,579,599 Hillard, W., see Peets,E.A. 533, Holgate,J.A., see Cambridge,G. Hershey,S.G., Altura,B. M., Or• 558 W. 300,330,387,426 kin,L.R. 577,578,599 Hills, M., see Hedges,A. 566, Holgate,1.A., see Collier,H. O.J. Hershey,S.G., Mazzia,V.D.B., 571 411,427 Altura, B. M., Gyure, L. Himwich,H.E., see Johns,R.J. Holland, D. R., see Steinberg, M. 577,599 561,571 I. 401,436,458,501 Hershey,S. G., see Altura,B.M. Hino,R., see Read,G. W. 59,73 Hollander,F., see Janowitz,H. 24,31,577-580,595 Hinshaw,L.B., Emerson,T.E., D. 252,290 Hershey,S. G., see Baez,S. 583, Iampietro, P. F., Brake, e. M. Holliman,A., see Hanahoe,T.H. 596 18,19,22,34 P. 64,71 Hertzman,A.B., see Davis,D.1. Hinshaw,L.B., Jordan,M.M., Hollis, T. M., Rosen, L.A. 112, 411,427 Vick,J.A. 586, 587,599 125 Herxheimer,H. 370, 379, 398, Hintze, K. L., Fischer,L. J. 543, Hollis,T.M., see Yarnal,J.R. 430,442,465,466,492 557 23,39 Herxheimer,H., Rosa,L. 398, Hirata,A.A., see Conway,A. M. Hollister, L. E., see Dunne, F. H. 430,466,492 478,485 591,597 Herxheimer, H., see Schild, H. O. Hirsch, E., Keil, W., Muscha• Holmberg, e.G., see Hansson,R. 398,435 weck,R., Rademacher,E. 134, 145 Herxheimer, H., Stresemann, E. 463,492 Holmstedt,B., see Tham,R. 465,466,492 Hirschelmann,R., see Beke• 131, 149 Herxheimer, H., see Armitage, P. meier, H. 506,511 Holobut, W. 463,492 465,481 Hirschowitz, B.l., Gibson, R. Holobut, W., see Klisiecki,A. Herxheimer, H., see Schild, H. O. 264,290 13, 15-18,22,35 454,501 Hirschowitz, B. I., Sachs, G., Holroyde,M.C., see Burka,J.F. Herzig,D.J., see Kusner,E.J. Hutchison, G. H. 54, 55 477,483 64,71 Hirschowitz, B.l., see Gibson, K. Holstein,B. 133,145 Hesbacher,P.T., see Rickels,K. D. 264,289 Holton, P., Curwain, B. P. 264, 565,572 Hirschowitz, B.l., see Gibson, R. 290 Hespe, W., DeRoos,A. M., 49, 53, 54,55 Holtz, P., Langeneckert, W., Nauta, W. Th. 521,522,557 Hirshfield, M., see Marsland, D. Palm,D. 463,492 Hespe, W., Nauta, W. Th. 523, 63,72 Holtzer, A., see Vallery-Radot,P. 557 Hirt, R., Berchtold,R. 228,247 405,436 624 Author Index

Holtzer, A., see Pasteur Vallery• Howie,D.L., see Dailey,R.E. Humphrey,J.H., Jaques,R. Radot, P. 442, 470, 498, 515, 516,555 470,492 499 Howie,D.L., see Way,E.L. Humphrey,J.H., Mota,1. 467, Hook, W.A., Brown, H., Oppen• 514,516,518.559 492 heim,J.J. 58,71 Howland,R.D., Spector,S. 23, Humphrey,J. H., see Austen, K. Hoppe,J.O., Lands,A.M. 180, 35 F. 68,69 210,562,571 Hoyle,J.C., see Dixon. W.E. Humphrey,J. H., see Brockhurst, Hoppe,J.O., see Lands,A.M. 7,8, 15-17,33 W. E. 473,483 180,211,387,409,431 Hruza,Z. 578,599 Humphrey,J.H., see Smith, W. Horakova,Z., Beaven, M.A. 467,501 164,167,172,586,587,599 Hsu, R., see Altura, B. M. 579, Horakova,Z., Votava,Z. 201, 595 Humphrey,J. H., see Stanworth, 210 Hsu,S.Y., see Witiak,D.T. D.R. 60,73 Horakova, Z., Zierdt, C. H., 204,214 Hunger,A., see Schmid,H.J. Beaven, M.A. 167,172 Huang,M., see Dombro,R. 202,213 Horakova,Z., see Atkins,F. L. 133,144 Hunt,J.H., see Brittain,R.T. 168 Huber, W.F., see Rieveschl,G. 194, 208, 226, 234, 236, 246, Horakova,Z., see Baxter,J. H. R. 182,212,389,409,434 388,426 163, 164, 167, 171 Hucker,H.B. 520,522,545,557 Hunter,J. H., see Reid, W. B. Horakova,Z., see Beaven, M.A. Hucker,H.B., Balletto,A.J., 197,212 110, 116, 123, 151, 155, 157, Staufer,S. C., Zacchei,A. G., Hunziker,F., Kuenzle,F., 158, 160, 163, 164, 167-169, Arison, B. H. 543-545, 557 Schmutz,J. 202,210 171 Hudgins, P. M., see Adams, M. D. Hunziker,F., see Ackermann,H. Horakova, Z., see Cohen, I. K. 23,30 446,480 168, 171 Hudgins, P. M., see Stubbins,J. Huppertz, W., see Wagner,]. Horakova,Z., see Kaplan,A. P. F. 345,367 27,29,39 164, 172 Hudson,A., see White,A.C. Hurn,M., see Code,C.F. 471, Horakova,Z., see Markley, K. 189,214, 226,249 485,585,588,597 163,164,167,172,440,496 Huebner,C.F., Donoghue,E., Hurwic,J., see Barbe,J. 230, 585-587, 590, 592, 593, 600 Wenk,P., Sury,E., Nelson,J. 231,246 Horakova,Z., see Protiva,M. A. 202,210 Hutchins, P. M., Goldstone,]., 201,212 Huebner,C.F., see Barrett, W.E. Wells,R. 580,581,599 Horakovit,Z., see Votava,Z. 446,481 Hutchison,G., see Gibson,K.D. 201,214 Hlibscher,H., see Wegmann,A. 264,289 Horakova,Z., see Webster,M.E. 471,503 Hutchison,G., see Gibson,R. 163, 164, 167,173 Hueper, W. c., Ichniowski, C. T. 49, 53, 54,55 Horclois,R., see Bovet,D. 389, 5,35 Hutchison, G. H., see Hirscho• 409,412,424,426 Hueper,W.c., see Ercoli,N. witz, B. I. 54,55 HorcIois,R.J. 180,210 381,409,428,447,487 Huttrer,c.p. 181,193,197, Horn,A.S., Coyle,J. T., Snyder, Huff,J.A., Davis,V.E., Brown, 210,215,217,247,390,409, S.A. 567,571 H. 140,145 430 Horner,G.J., see Halmagyi,D. Huggins, A. K., Woodruff,G. N. Huttrer,c.p., Djerassi,C., F.J. 16,21,34 133,145 Beears, W.L., Mayer,R.L., Horning,E.C., see Fish,M.S. Hughes, E. W. 266, 274, 290 Scholz,C.R. 180,210, 409, 521,556 Hughes,F. W., Forney,R.G. 430 Horsfield, G. I. 79,90 562,571 Huttrer,c. P., see Leonard,F. Horton,B. T., see Benson,A.J. Hughes,M.J., Coret,I. A. 10, 181,211,215,217,247 8,32 35,401,430,440,492 Huttrer,c. P., see Mayer, R. L. Horton,B.T., see Wakim,K.G. Hughes,M.J., see Coret,I.A. 409,432,449,497 19,39 440,485 Hutzel,M., see Lorenz, W. 109, Hosli,L., see Haas,H.L. 568, Hughes,R., see Grahn,B. 111, 126, 143, 147 571 124 Huurrekorpi,L., see Alberty,]. Hosoda,S., Nakamura, W., Hughes,R. C., see Kessler, E. 399,425,455,480 Snell, K. C., Stewart, H. L. 584,599 Huzsti,L., Sourkes,T. 117,125 110,125 Hugli,T.E., see Johnson,A.R. Huzsti,Z., Kasztreiner, E., Houki,S. 10,34 78,90 Kurti,M., Fekete,M., Borsy. Howard,J.M., see Flynn,J.T. HugIi,T.E., see Mahler,R. 24, J. 117,125 584,598 36 Hye,H.K.A., see Adam,H.M. Howard, K. L., see Vaughan,J.R. Hugo,R., see Vinegar,R. 507, 114, 122, 568, 570 180,214 512 Howell,J., see King,C.T. 526, Hugues,J., see Lecomte,J. Iampietro, P. F., see Hinshaw, 557 470,494 L.B. 18,19,22,34 Howell,J. P., see Drach,J.C. Huidobro,H., see Cany,J. 184, Ichniowski,C. T., see Hueper, 519,521,555 208 W.C. 5,35 Author Index 625

Ide, W. S., see BaltzJy,R. 227, Ishizaka,K., see Tomioka,H. Jacobson,M., see Kuntzman, 246 67, 74 R. 178,211 Idson,B. 215, 217, 247, 445, Ishizaka, T. 93, 107 Jacobsson,S., see Agrup, P. ~92 Ishizaka, T., Ishizaka, K., 142, 143 Iff,E.T., Vaz,N. M. 474,492 Orange,R.P., Austen,K.R. Jacques,R., see Riesterer,L. Imai, Y., see Chiba,S. 463, 484 61,71 509,511 Imamura, H., Okada, T., Matsui, Ishizaka, T., Soto, C. S., Jaeger, M.S., see Litchfield, E., Kato, Y. 540,557 Ishizaka, K. 60, 71 J.T.,Jr. 386,409,432, 441,465,496 Imamura, H., see Inui,J. 459, Ishizaka, T., see Ishizaka, K. Jagenau,A.H., see Janssen, 493 60, 71,93, 107 Ismail, M. M., Tanner, C. E. P.A.J. 562,571 Impicciatore, M., see Bertacinni, 474,493 Jageneau,A.H.M., see Schaper, G. 264,287 Ison,R.R. 183,188,210 W.K.A. 531,558 Inch, T. D., see Brimblecombe, Ison,R.R., Casy,A.F. 189- Jaju, B. P., Kirsten, E. B., Wang, R. W. 178,208 191,210,238,247,312,331 S. C. 567,571 Inderbitzin, T. 467,492 Ison,R.R., Franks,F.M., Soh, Jaju,B.P., Wang,S.C 567, Inderbitzin, T., Craps,L. 473, K.S. 180, 188, 190, 193, 571 493 194,203,210,218,226,236- Jakschik,B.A., Marshall,G.R., Ing,H.R., Dawes,G.S., Wajda, 238,240,247,312,331,387, Kourik,J. L., Needleman, P. I. 416,430 388,398,430 583,599 Ingraham,R. c., Wiggers,H. C. Ison,R.R., see Casy,A.F. 187, Jakschik, B. A., McKnight, R. C, 589,590,599 193, 196,208, 240, 242,246 Marshall,G.R., Feldhaus, R. A., Needleman, P. Ingraham, R. C., see Wiggers, Ison,R.R., see Ham,N.S. 583, 584, 599 H. C. 578,602 182,210 J alon, P. D. G., see Velasq uez, Ingvar,D.H., see Risberg, Israel,1.S., see Dobkin,A.B. B.L. 387,388,437 A.M. 569,572 566,570 James,G. W. L. 463, 493 Innes, I. R. 462,463,493 I tskovitz,H. D., see Campbell, Intaglietta, M., see Mahler,R. James, G. W. L., see Ch urch, W.B. 22,33 24,36 M. K. 472,485 Ivy,A.C., Bachrach,W.H. Inui,J., Imamura,H. 459, 493 James,G.W.L., see Collier, 252,290 Ionis,J., see Cohen,M.B. 421, H.O.J. 411, 427, 452, IVy,A.C., see Grossman,M.1. 427 462,485 42,55 Irono,S. 442,493 James,K.E., see Teutsch,G. Ivy,A.C, see Roback,G.S. Irwin, N. T., see Harkins,J. L. 569,573 564,572 566,571 James,M.N.G., Williams, Iwasa.J., see Fujita,T. 216,246 Isaac,L. 116,125 G.J.B. 191, 195, 196,210, Isaac, L., Cho, A. K., Beaven, Iwasaki,T., see Kikkawa,M. 211,236,247 M.A. 112, 125 520,557 Jancso, N. 423,430 Isaac,L., Goth,A. 462, 493 Izard,S.R., Henson,E.C, Janoff,A., Nagler,A. L., Baez,S., Isenberg, J. I., see Mainardi, M. Collins,A.D., Brunson,J.G. Zweifach,B. W. 576, 599 463,493 265,291 Janowitz, H. D., Hollander, F. Iseri, O. A., see Lagunoff, D. 252,290 75, 78, 82, 85, 91, 93, 107 Janssen, M. J. 266-268, 290 Jablonski, D. V., see Wilson, Isersky,C., see Kulczicky,A.,Jr. Janssen,P.A.J., Jageneau, R. F. 578, 602 61,71 A. H., Niemegeers, CJ. E. Ishida, Y., Oshima,H., Aibara, Jackson,J.L., see Archibald, 562,571 1. L. 206,207 S.,Ohmoto,M. 375,377, Janssen,P.A.J., see Awouters, 379 Jackson,M., see Peets,E.A. F. 446,481 Ishida,V., Oshima, H., Sawada, 533,558 Janssen, P.A.J., see Schaper, A., Sakai,K. 375-377,379 Jackson,R. T., see Bentley, W. K. A. 531,558 Ishikawa, E., Toki,A., Mori• A.J. 25,32 Jaques, R., Schar, B. 448, 474, jama, T., Matsuoka, Y., Jackson,R.T., see Dennis,R.G. 493 Aikawa, T., Suda, M. 111, 26,33 Jaques,R., Scheibli, K. 217 125 Jackson,R. T., see Stovall,R. Jaques,R., see Domenjoz,R. Ishimova, L. M., see Ado, A. D. 411,436 381, 409, 422, 428, 447, 486 468,480 Jacob,R., de Barre,F. 217 Jaques,R., see Humphrey, Ishizaka, K., Ishizaka, T. 93, Jacob,S., Friedman,E. W., J.H. 470,492 107 Levenson,S., Glotzer, P., Jaros,S. M., see Castillo,1.C. Ishizaka, K., Tomioka, H., Frank,H.A., Fine,J. 388, 409,427 Ishizaka, T. 60, 71 589,590,592,599 Jarrousse, M. J., Regnier, M. T. Ishizaka, K., see Ishizaka, T. Jacobsen,S., see Beaven, 183,211,234,236,247 60,71 M.A. 110, 123,151, 155, Jayasundar,S., Periyasami, Ishizaka, K., see Konig, W. 157, 158, 160, 163, 164, S.M., Bhide,N.K. 370, 61,71 167-169, 171 373, 375-377, 379 626 Author Index

Jeanjean,M.F., see Cort,1.H. Johnson, L. P., Sloop, R. D., Jordan,M.M., see Hinshaw, 579,597 Jesseph,J.E. 543, 544, L.B. 586,587,599 Jenkins,B.D., see Sachs,G. 46, 557 Josephson,!., Renaud,J.F., 56 Johnson,L.R. 42-45, 47, 55 Vogel, S., McLean, M., Jenkins,D.J.A., see Milton• Johnson,L.R., Aures,D. 43, Speralakis,N. 401, 431 Thompson,G.J. 265, 292 48,55 Jost,K.,see Cort,J.H. 579, J ensen,J. 60, 71 Johnson,L.R., Aures,D., Yuen, 597 Jensen, K., Nielsen, P. H. 268, L. 45,55 Jourdan, F., Chatonnet,J. 290 Johnson,L.R., Grossman, 590, 592, 599 Jerchel,D., Fischer, H., Kracht, M.l. 47, 50,55 Jourdan, F., see Chambon,M. M. 181,211 Johnson,L.R., Guthrie, 585-587,596 Jesseph,J.E., see Johnson,L. P. P.D. 45,55 Joyner,W.L., see Carter,R.D. 543, 544, 557 Johnson,L.R., Jones,R.S., 26,33 Jilek,J.O., Seidlova,V., Svatek, Aures,D., Hakanson,R. Joyner, W.L., see Renkin,E.M. E., Protiva, M., Pomykacek, 43-45,56 26,37,423,434 J., Sedivy,Z. 201, 211 Johnson, L. R., Tumpson,D.B. Jubiz,W., see Anderson,F.L. Jobke,A., see Hahn,F. 468, 47,56 584,596 490 Johnson,L.R., see Aures,D. Jucker,E., Ebnother,A. 202, Johansen, T., Chakravarty, N. 44,45,55 211,234,247 58,71,102,103,105,107 Johnson,L.R., see Caren,J.F. Jucker,E., see Ebnother,A. Johansson, B., see Mellander,S. 45,48,55 234,246 580, 581, 600 Johnson,L.R., see Tumpson, Jucker,P., see Edlbacher,S. Johansson, M.-B., Wetterqvist, D.B. 47,56 381,428 H. 110,125 Johnson,N.M., see Fish,M.S. Judd,A.R., Henderson,A.R. Johansson, M.-B., see Berg, B. 521,556 180,211 115, 123, 140, 142, 143 Johnson,P.C. 23,35 Judd, C. 1., see Biel,J. H. Johansson,S.G. P., see Johnson, P. c., see Chara• 201,208 Stanworth,D.R. 60, 73 lampous,K.D. 545,555 Juhasz,E., see Kovacs,A. 369, Johns,R.J., Himwich,H.E. Johnston,M. 110,125 379 561,571 Johnston, M., Kahlson, G. Juhasz,E., see Kovacs,B.A. 117,125 Johnson,A.R., Erdos,E.G. 369,380 Johnston, M., see Ahlstrom, 60,71 Jukarainen,E., see Klinge,E. C.G. 110,122 20,35 Johnson,A.R., HugJi, T.E., Johnston,R.L., see Buhler, Miiller-Eberhard, H.J. D. R. 536, 537, 555 Julou,L., see Jolles,G. 541, 78,90 Johnstone, E. E., Claghorn, 557 Johnson,A.R., Moran,N.C. J.L. 546,557 Julou,R., see Courvoisier,S. 58, 61, 71, 78, 79, 90, 91, Joiner,P.D., Wall,M., Davis, 446,485 105, 106, 107 L.B., Hahn,F. 454, 455, Juretic,F., see Bordeleau, Johnson,A.R., Miiller-Eber• 493 J.M. 565,566,570 hard,H.J. 60,71 Joiner, P. D., see Weikel, Jurkiewicz,A., see Furchgott, Johnson,A.R., see Goth,A. J.H.,Jr. 540,559 R.F. 328,331 57,70 Jolles,G., Julou,L., Terlain,B. Jurkiewicz, N. H., see Furchgott, Johnson,A.R., see Mahler,R. 541,557 R.F. 328,331 24,36 Jonassen, F., Granerus, G., Jurna,l., see Giertz,H. 441, Johnson,A.R., see Sandusky, Wetterqvist,H. 141, 146 445,448,452,468,489 C.B. 60,73 Jonassen, F., Wetterqvist,H. Johnson, C. L., Mizoguchi, H. 135, 138, 141, 146 459,493 Jondorf, W.R., Maickel, Kabasakalian, P., Taggart, M., Johnson, D., see Lardy,H.A. R.P.,Brodie,B.B. 535, Townley,E. 532, 533,557 557 Kafoe, W. F., see Hespe, W. 101, 108 Jones,H. M., Brady,E.S. Johnson, D. E., see Rodriguez, 547,557 513,514,523,557 C.F. 521,539,558 Kahl,G.-F., Netter,K.F. 98, Johnson,E.M.,Jr., see Jones, R. G. 256, 290 107 Yellin,T.O. 506, 512 Jones,R.G., see Ainsworth,C. Kahlson,G., Rosengren,E. 1, Johnson,G.L., Kahn,J.B.,Jr. 286,287 35, 110, 111, 119, 122, 125, 462, 463,493 Jones,R.S., see Johnson,L.R. 135, 137, 146 Johnson,G.S., B1alock,A. 43-45,56 Kahlson,G., Rosengren,E., 5,7,8,35 Jones,T.S.G., see Adamson, Steinhardt, C. 112, 117, 125 Johnson,H.L., Beaven,M.A., D. W. 190, 192,207 Kahlson, G., Rosengren, E., Erjavec,F., Brodie,B.B. Jones, W. J., OrviIIe-Thomas, Svahn,D., Thunberg,R. 114,125 W.J. 274,290 43, 44, 56, 137, 146 Johnson, H. L., Ellis, M., Jonsson,G., see Lidbrink, P. Kahlson, G., Rosengren, E., Mitoma,C. 115, 120, 125 567,571 Svensson,S.-E. 110, 125 Author Index 627

Kahlson,G., Rosengren,E., Kamm,J.J., Szuna,A., Kuntz• Kazimierczak, W., see Thunberg,R. 43-45,56, man,R. 533,557 Czerwiilska, U. 478, 486 110, 125 Kamm,J.J., VanLoon,E.J. Keating, V.,Jr., see Code,CF. Kahlson,G., Rosengren,E., 533,557 417,421,427 Westling,H. 137,146 Kaneko, T., see Akabori,S. Keatinge,W.R. 29,35 Kahlson,G., see Ahlstrom,CG. 286,287 Keil, W., see Hirsch,E. 463,492 110,122 Kang, L., see Da Vanzo,J. P. 562,570 Keiser, H. R., see Cohen, I. K. Kahlson,G., see Dencker,H. 168,171 112,123, 139, 144 Kanno, T., Cochrane, D. E., Keller,C.J. 13,19,35 Douglas, W. W. 59, 71 Kahlson,G., see Folkow,B. Keller, R. 78,91,471,493 183,209,252,289 Kanno, T., see Douglas, W. W. 463,486 Keller, R., see Giertz, H. 471, Kahlson,G., see Graham,P. 472,489 110, 124 Kantor,F.S., see Phair,1. P. 467,499 Kellermeyer, R. W., Warren, Kahlson,G., see Grahn,B. K.S. 510,511 111, 119, 124 Kapeller-Adler, R. 444,493 Kaplan,A. P., Gray, L., Shaff, Kelley,F.R., see Thomas,J.W. Kahlson,G., see Johnston, M. R.E., Horakova,Z., Beaven, 183,213 117, 125 M.A. 164,172 Kelly,R.G., see Ellenbogen,L. Kahlson,G.S., see Emmelin,N. Kaplan, M.A., see Ehrlich, N.J. 116,124 453,486 185,209 Kelvin,A.S. 140,146 Kahn,J. B., Jr., see Johnson, G. L. Kelvin,A.S., see Turnbull,M.J. 462,463,493 Karady,S. 377 Karady,S., Kovacs,A. 377,379 140. 141, 149 Kaiser,M.E., see Loew,E.R. Karady,S., Kovacs, A., Petri,G. Kempf,A.H., Feinberg,S.M. 182,211,381,389,409,411- 377,379 399,431 413,416,417,432,439,449, Karady,S., Kovacs,B.A., Kennard,O., Walker,J. 257, 453, 465, 496 Kovacs,J., Szerdahelyi, M., 291 Kaiser, M. E., see Winder, C V. Vajda, P. 369,370,379 Kennedy,J., see Schayer, R. W. 183,214,390,409,413,416, Karady.S., see Fearn,H.J. 2,4, 131, 136, 148 437 34 Kennedy,J.C., see Code,CF. Kales,A., Kales,J.D. 565,571 Karjala, S. A., see Schayer, R. W. 471,485,585,588,597 Kales, A., see Kales,J. D. 565, 282,293 Kennedy,J.C, see Cody,D.T. 571 Karlson, E. L., see Cohen,S. G. 471,472,485 Kales,J.D., Tan,T.L., Swearin• 470,485 Kerkut,G.A., see Woodruff, gen, C, Kales,A. 565, 571 Kase, N., see Green,J. P. 140, G.N. 133,150 Kales,J. D., see Kales, D. 565, 141,145 Kerp, L. 83, 91 571 Kashiwagi, T., see Okuma, T. Kerr,J. W. 131,146 Kaley, G., see Messina,E.J. 23, 562,566,572 Kerr,J. W., see Dowell,R.C 36 Kassarich, J., see Rosen thale, 142, 144 Kaliner, M.A., Austen, K. F. M.E. 444,500 Kessler, E., Hughes, R. C, 57, 61, 62, 64, 71, 105, 107, Kassay, L., see Csaba, B. 134, Bennett, E. N., Nadela, S. M. 167, 172 144,472,474,486 584,599 Ka1iner, M.A., Orange,R. P., Kasztreiner, E., see H uzsti, Z. Kessler,G.-F., see Chiesa,A. Austen, K. F. 64,67,71 117,125 469,484 Kaliner,M.A., Orange,R. P., Katagiri, K., see Harada, M. Kessler, H. 275,291 Koopman, W.J., Austen, 467,473,475,491 K.F., LaRaia,P.J. 67,71 Kessler, H., Leibfritz, D. 275, Kataoka,K., de Robertis,E. 291 Kaliner, M.A., Wasserman,S. I., 120,125,568,571 Keston,A.S., Udenfriend,S., Austen, K. F. 64, 71 Kataoka,S., Takabatake,E. Cannan,R.K. 152, 172 Kaliner, M. A., see Orange, R. P. 521, 522, 534, 542, 543, 557 Keston,A.S., Udenfriend,S., 61,67, 72, 167, 172 Kato,R., Chiesara,E., Levy,M. 152,172 Kaliner, M.A., see Tauber,A.1. Vassanelli, P. 550, 557 64,73 Kato,R., Onoda, K.-I., Kesztyi.is, L., Szilagyi, T., Csaba, Kalino,R.E., see Brunson,J.G. Takanaka,A. 521,557 B., Cernyanszky, H., Kavai, 590,596 Kato, Y., see Imamura, H. 540, M. 455,493 Kallas, P., Melander, B. 474, 557 Khatri,I.M., see Cohn,J.N. 493 Katus,H., see Senges,J. 459, 579, 597 Kallos, P., Pagel, W. 406, 431, 501 Kidder,H., see Caviezel,R. 465,493 Kauzmann,N. 315,331 446,484 Kamenar, B., Prout, K., Kavai, M., see Kes7tyi.is, L. Kido, M. 459,493 Ganellin,CR. 271,290 455,493 Kier, L. B. 279,291 Kameyama, N. 266, 274,290 Kawahara,R., see Okuma,T. Kihara, F. 457,493 Kamm,J.J., Ferullo,CR., 562, 566, 572 Kikkawa,M., Sasaki,D., Miller,D., Vanloon,E.J. Kay,R.N.B., see Sjaastad,b.V. Iwasaki,T., Ueda,J. 520, 533,557 138, 148 557 628 Author Index

Killick, S. W., see Ambache, N. Kobayashi, Y., Kupelian,J., Kordecki,R., see Delaunois, 440,456,481 Maudsley,D.V. 116,126 A. L. 5, 7, 8, 15, 33 Kim, K. H., see Hansch, C. 334, Kobayashi, Y., Maudsley, D. V. Korduba,C.A., Veals,J., 358,366 45,56, 109, 112, 116, 118,126, Symchowicz,S. 567, 571 Kim,K.S., Backus,B., Harris, 152,160,161,164,165,172 Korduba,C.A., see M., Rourke,P. 132,146 Kobayashi, Y., see Maudsley, Symchowicz,S. 567, 573 Kim, Y.S., Glick,D. 112,126 D. V. 45,54,56,265,292, Koren, J. G., see Hirt, R. C. 266, Kimmig,J, 388,431 444,496 290 Kimura,E.T., Young, P.R., Kobayashi, Y., see Schayer, Korner, P.l. 23,35 Richards, R. K. 443, 448, R. W. 152,173 Kornfeld, L., see Birkeland, J. M. 493 Kobold,E. E., Thal,A. P. 575, 467,482 King,C.T., Howell,J. 526,557 599 Korolkovas,A., Tamashiro,K. King, C. T. G., Weaver,S. A., Koch,A., see Kuntzman,R. 302,331 Narrod,S.A. 526, 527, 558 178,211 Koshland,D.E. 295,331 King,C. T.G., see Narrod,S.A. Kockum, I., see Dencker, H. Koslowski,L. 585-587,599 526,527,531,558 112, 123, 139, 144 Koslowski, L., Marggraf, W., King,C. T.G., see Posner,H.S. Koepf,G.F., see Arbesman,C.E. Scheele, W. 586, 587, 599 529,558 421,425,442,446,481 Kosmicki, B. P., Mizgiert, W. K. King,C.T.G., see StelTek,A.J. Kollmeier,J., see Giertz,H. 585, 587, 599 529,559 441,452,468,489 Koster,R., see Burns,J.J. 529, King,J.H., see Winklemann, KollolT,H.G., see Reid, W.B. 549, 551, 555 R.K. 27,39 197,212 Kourik,J.L., see Jakschik,B.A. King,J.W., see Dreyer,N.B. Kolodej,A., see Kowalewski,K. 583,599 478,486 51,53,56,265,291 Kovacs,A., Juhasz,E. 369,379 Kirkley,D.E.,Jr., see McLaurin, Komarov,S.A. 41,56 Kovacs,A., Kovacs-Juhasz, E. J. W. 411,433 Komarov,S.A., see Shay,H. 369,379 Kirsten,E.B., see Jaju,B. P. 378,380 Kovacs,A., see Karady,S. 377, 567,571 Komoto,S., see Tasaka,K. 59, 379 Kizuka, H., see Maudsley, D. V. 73 Kovacs,B.A. 369,379 265,292 Konig,W., Ishizaka,K. 61, 71 Kovacs,B.A., Goodfriend, L., Klahm,G.R., see Snyder,F.H. Konturek,S.J., Biernat,J., Rose,B. 374,377,379 515,559 Oleksy,J. 265, 291 Kovacs,B.A., Juhasz,E. 369, Klarer, W., see Miescher, K. Konturek,S.J., Demitrescu, T., 380 181,212 Radecki, T., Dembinski,A. Kovacs, B. A., Melville, K.1. Klebe, H., see Schuler, W.A. 265,291 370-375,380 198,213 Konturek,S.J., Oleksy,J., Kovacs,B.A., Pelletier, G., Kleemen,E. 423,431 Wysocki,A. 50,56 Rose,B. 370,374,378,380, Klein, I., Levey,G.S. 401, 431, Konturek,S.J., Radecki, T., 455,493 458,493 Demitrescu, T., Dembinski, Kovacs,B.A., Voith,K. 376, Klinge,E., Mattila,M.J., A. 265,291 378,380 Penttilii, 0., J ukarainen, E. Konturek,S.J., Tasler,J., Kovacs, B.A., see Archer,R.K. 20,35 Obtulowicz, W., Cieszkow• 369, 372,378 Klinkhammer,H.J., see Treibs, ski,M. 265,291 Kovacs,B.A., see Feldberg,W. W. 199,213 Konturek,S.J., Tasler,J., 372,379 Klisiecki,A., Holobut, W. 13, Obtulowicz, W., Rehfeld,J.F. Kovacs,B.A., see Filderman, 15-18,22,35 265,291 R. B. 378,379 Klupp,H., Konzett,H. 454, Konturek,S.J., see Grossman, Kovacs,B.A., see Karady,S. 493 M. I. 49-53, 55, 264, 289 369,370,379 Klutch,A., see Conney,A.H. Konzett,H., Rossler,R. 411, Kovacs,B.A., see Pelletier,G. 551,555 431,452 374,380 Klutch,A., see Kuntzman,R. Konzett,H., see Klupp,H. 454, Kovacs,B.A., see Wakkary,J.A. 521,526-529,531,558 493 378,380 Knobloch,E., Macha,F., Exner, Koono, M., see Hayashi, H. Kovacs,E.M., Heisler,S. 133, 0., Protiva,M. 229,247 471,492 146 Knoll, A.-G. 182,211 Koopman,P., see Ariens,E.J. Kovacs,J., see Karady,S. 369, Knoohuizen, M., see Goth,A. 324,329 370,379 63, 70, 100, 107 Koopman, W. J., see Kaliner, Kovacs-Juhasz, E., see Kovacs, Knop,J., see Schmutzler, W. M.A. 67,71 A. 369,379 444,501 Kopin,I.J., see Baldessarini, Kowalewski, K., Kolodej, A. Kobayashi,R.M., Kopin,U. R.J. 163, 171 51, 53, 56, 265, 291 172 Kopin,U., see Kobayashi,R. M. Kozuka,H., see Maudsley,D. V. Kobayashi,T., see Fukuda,T. 172 45,54,56 575,598 Kopp,K., see Werle,E. 198, Kracht,M., see Jerchel,D. 181, Kobayashi, Y. 83, 91, 110, 126 214 211 Author Index 629

Kraft, E., Zimmermann,B.G. Kukovetz, W. R., Poch, G. 463, Laflamme,G., see Pelletier,G. 19,35,462,493 494 370,373-378,380 Krajewska,J. M., see Maslinski, Kukovetz, W.R., poch,G., LagunolT,D. 58, 59, 71, 87, C. 138, 147 Wurm,A. 401,431 91 Kniko, K., see Giertz, H. 468, Kukovetz, W.R., see Poch,G. LagunolT, D., Benditt, E. P. 489 9, 12, 37, 401,434, 458, 499 75,91 Krarup,N. 17,22,35 Kulczicky,A.,Jr., Isersky, c., LagunolT, D., Phillips, M. T., Krasno,L.R., see Roback,G.S. Metzger,H. 61,71 Iseri,O.A., Benditt,E.P., 564,572 Kulczicky,A., Jr., Metzger,H. 75,78,82,85,91,93,107 Krause,E.G., see Wollenberg,A. 60,61,71 LagunolT, D., Pritzl, P., Mueller, 401,437 Kumler,W.D. 274,291 L. 89,91 Kraushaar,A. v. 409,431 Kumler,W.D., Fohlen,G.M. Laidlaw,P.P., Dale,H.H. Krauss,S., Gilbert,H.S., 259, 266, 268,291 2, II, 12, 23, 33 Wasserman,L.R., Lurinsky, Kunchur,N.R., Truter,M.R. Lambert,E.H., Rosenthal,S.R. L.R. 110,126 259, 268, 291 405,431 Krell,R.D., see Chakrin,L. W. Kuntzman,R., Jacobson, M., Lambert,1., see Duchene• 440,484 Tasi,l., Burns,J.J., Burchall, Marullaz,P. 409,428 Kretzschmar,R., Giertz,H., J., Koch,A. 178,211 Lambling,A., see Bonfils,S. Mitze,R., Teschendorf,H.J. Kuntzman,R., Klutch,A., Tsai, 378,379 468,493 I., Burns,J.J. 526-529,531, Lampart, c., see Schwartz, Kretzschmar,R., see Hahn, F. 558 J.-c. 119, 129, 170, 173 445, 454, 457, 467, 468, 472, Kuntzman,R., Phillips,A., Lamson,P.D., Abt,A.F., 490,491 Tsai,l., Klutch,A., Burns, Oosthuisen, Rosenthal, Kretzschmar,R., see Teschen• J.J. 521,527,529,558 S. M. 3, 4, 17, 35 dorf,H.J. 468,502 Kuntzman,R., see Kamm,J.J. Landau,S.W., Gay,L.N. 399, Krieger,H. 305 533,557 431,441,448,455,467,494 Landau,S. W., Herriott,H.J., Krnjevic, K., see Galindo, A. Kunz, W. 183,211 568,570 Kupelian,J., see Kobayashi, Y. Gay,L.N. 406,409,431 116,126 Landau,S. W., Marriott, Krogh,A. 23,35 H.J.L.,Gay,L.N. 441,442, Kuriaki, K., Uchida, T. 462, KrUger,P.G., Bloom,G.D. 448,451,465,494 463,494 78,79,91 Landau,S. W., Nelson, W.A., KrUger,P.G., Bloom,G.D., Kurihara, N., Shibata, K. 455, Gay,L.N. 417,418,431, Diamant,B. 78,79,91 493 443, 463, 494 KrUger,P.G., see Diamant,B. Kurti, M., see Huzsti,Z. 117, Landez,J.H., see Medina, M.A. 58, 59, 70, 79, 90 125 117,127 Krull,P., see Giertz,H. 444, Kury,H., see Bernauer, W. Landis, E. M., Pappenheimer, 489 442,462,464,482 J.R. 24,35 Krupp,P., see Riesterer,L. Kurzawa,Z., Krzymien,M. Lands,A.M., Hoppe,J.O., 509,511 281,291 Siegmund, O. H., Luduefia, Krzymien, M., see Kurzawa, Z. Kusche,J., see Lorenz, W. 109, F.P. 180,211,387,409, 281,291 126, 143, 147 431 Kshnyakina,A. N., see Rannev, Kusner,E.J., Dubnick,B., Lands,A.M., see Hoppe,J.O. N. V. 266,274,277,292 Herzig,D.J. 64,71 180,210,562,571 . KUbler, W., see Senges,1. 459, Kutter,E., Hansch,C. 177, Landsberg, L., see MolinolT, 501 211, 216, 232, 247, 362, 366 P.B. 153,172 KUhas,E., see Arnold,H. 446, Kuye,J.O., see Levi,R. 9, 12- Lange,A., see Giertz,H. 468, 465,481 14,21,35,400,401,432,459, 489 460,495,593,600 Kuenzle,F., see Hunziker,F. Lange, W.E., Theodore,J.M., 202,210 Pruyn,F.J. 532,558 KUttner, K. 83, 91 La Barre,J., Reuse,J. 399,431, Langeneckert, W., see Holtz, P. Kugler,1., Thurmayr,R., Rode, 442,455,494 463,492 C. P. 565,571 La Belle, A., Tislow,R. 193, Lantos,J., see Cook, T.J. 421, Kuhar,M.J., Taylor,K.M., 211, 381,409,431,448,494 427 Snyder,S. H. 132, 146 La Belle,A., see Tislow,R. Lanz, W., see Bohnstedt,R. M. Kuhar,M.J., see Dismukes,K. 409,436, 532, 559 467,482 169,172 La Belle,C.W., Tislow,R. 532, La Raia,P.J., see Kaliner,M.A. Kuhar,M.J., see Snyder,S.H. 558 67,71 121, 129 Laborde,C., see Parrot,J.-L. La Raia,P.J., see Orange,R. P. Kuida,H., see Anderson,F. L. 82,91,467,498 61,67,72 5, 15, 17,31,584,596 LaDu,B.N., see Brodie,B.B. Lardy,H.A., Johnson,D., Kuizenga,M.H., see Van der 549,554 McMurray, W. C. 101,108 Brook,M.J. 197, 214, 388, Laflamme,G., see Gauthier,P. Larsen,S., see Cotton,F.A. 437,450,455,502 370,379 257,288 630 Author Index

Lasagna,L., see Sjoqvist,F. Lee,T.J.-F., see Bevan,J.A. Leventhal, M. M., see Majno, G. 561, 564, 566,572 27,32 24,26,36,423,432 Last,M.R., Loew,E.R. 471, Leeming; P. R., see Augstein, J. Leventhal, M. M., see Pietra, G. 494 203,207 G. 26,37 Latt,N., see Carroll, P.R. 11, Lefcort, M., Francis, L. E., Levey,G.S., see Klein,!. 401, 33 Melville, K.1. 373-375, 431,458,493 Latt, N., see Glover, W. E. 440, 378,380 Levi,R. 9, 13, 14,35,457,460, 470,489 Lefebvre,1., see Parrot,J.L. 495 Lauener,H., see Ackermann,H. 389,421,434 Levi,R., Allan, G., Zavecz,J.H. 446,480 Lefer,A. M. 575, 576, 581, 583, 1, 35, 443, 460,495 Lauener,H., see CaviezeI,R. 584,600 Levi,R., Capurro,N. 459, 495 446,484 Lefer,A.M., see Glenn,T.M. Levi,R., Capurro,N., Lee,CH. Laval,J., see Pascal,J. P. 17,37 575,598 2,4,9,12,13, 35,401,432, Lawrence,E. P., see Fish, M.S. Lehmann,G. 178, 203,211, 440,495 521,556 381,409,417,431,449,453, Levi,R., Kuye,J.O. 9, 12-14, Lawrence, G. I., see Hansch, C 495,516,558 21,35,400,401,432,459,460, 262,290 Lehmann, G., Randall,L.O., 495,593,600 Lear,E., Suntay,R., Pallin,I.M. Hagan,E. 203,211,388, Levi,R., Lee,CH. 401,432 Chiron,A.E., Fisch,H.J., 413,431 . Levi,R., see Capurro,N. 401, Abrams,G. 566,571 Lehmann, G., Young,J.M. 426,440,458,459,460,484 Leau,O., see Courvoisier,S. 413,431, 442, 453, 456, 466, Levine,R.J. 140,146 446,485 495 Levine,R.J., Sato,T.L., Sjoerd• Leavitt,M.D., Code,D.F. 471, Lehmann, P.A., Rodrigues de sma,A. 116,126 431 Miranda,J.F., Ariens,E.J. Levine,R.1., Senay,E.C 112, Leavitt,M.D.,Jr., see Code, 352,366 126 CF. 417,421,427 Lehrer,R. I., see Bourne,R. I. Levine, R. 1., see Gillespie, E. Leazar,M.A. 566,571 61,69 59,63,70 Leblanc,J. 114,126 Leibfritz,D., see Kessler,H. Levine,R.J., see Phair,J. P. Lecomte,J. 464, 470, 494 275,291 467,499 Lecomte,J., Beaumariage, Leinweber,F.1., see Taylor,R.J., Levinson,S. 0., see Neuwelt,F. M.L. 470, 477, 494, 588, Jr. 116, 129 5,36 Levy,D.A., Carlton,1.A. 63, 591,600 Leme,J.G., see Rocha e Silva, Lecomte,1., Cession-Fossion, M. 443,500 71 A. 472,494 Levy,D.A.,Osler,A.G. 60,71, Lecomte,1., Dresse,A. 471, Lemmi,CA.E., see Moore,T.C. 72 494 110,127 Levy,L. 467,473,495 Lecomte,J., Fischer, P. 462, Lenney,J.F., see Read,G. W. Levy,L. II, Seabury,J.H. 398, 470,494 59,73 432 Lecomte,1., Hugues,J. 470, Lenzner, A. R., see Arbesman, C. Levy,M., see Keston,A.S. 152, 494 E. 421,425 172 Lecomte,1., Mazzella, H., Leo, A., Hansch, C., Elkins, D. Levy, M. N., Blattberg, B. 576, Vanremoortere, E. 459,494 280,291,358,367 600 Lecomte,1., see Cession• Leo,A., see Hansch,C. 334, Levy, M. N., see Blattberg, W. Fossion,A. 463,484 358,366 575,596 Lecomte,J., see Vanremoortere, Leonard,F., Hutter,C.P. 181, Levy,S.E., see Blalock,A. 17, E. 471,503 211,215,217,247 18,32 Ledda, F., Fantozzi, R., Mugelli, Leonard,F., Solmssen, U. V. Lewis,A.1., Eyre, P. 2, 6, 35 A., Moroni,F., Mannaioni, 409,431 Lewis,A.J., Nicholls,P.J. 111, P.F. 10, 35, 401, 431, 458, Leonard, F,. see Ercoli, N. 387, 126,132-134,146 494 428 Lewis,A.J., see Eyre,P. 6, 16, Ledda,F., see Fantozzi,R. Lepow, I. H., see Dias da Silva, 34,476,477,487 400,401,429 W. 60,70 Lewis,A.J., see Zuskin,E. 398, Ledda,F., see Moroni,F. 458, Lerman,S., Goldfeder,A. 409, 437 497 431 Lewis,D. H., see Du Bois,A. B. Lee, C-C 534, 535, 558 Lessard, P., see Pelletier, G. 410,428 Lee,CH., see Levi,R. 2, 4, 9, 374,375,377,378,380 Lewis, G. P. 600 12, 13,35,401,432,440,495 Lesuer, W. M., see Campaigne, Lewis,G.P., see Graham,1.D.P. Lee, D. 369,380 E. 180,208 390,430 Lee, H. M., Anderson, R. C, Lette,M.P., Moraes,C.R.de, Lewis,M.N., see Ercoli,N. Harris,P.N. 187,211,448, Garcia Leme,J. 478,495 381,409,428,447,487 465,495 Levenson,S., see Jacob,S. 589, Lewis, T. 1, 26, 35, 420, 432, Lee,H.M., Dinwiddie,W.G., 590, 592, 599 575, 576, 584,600 Chen,K.K. 465,495 Levenson,S. M.,see Nagler,A.L. Lewis, T., Grant, R. T. 420, 432 Lee,J.S. 24,35 575,600 Leya,A. 442,470,495 Author Index 631

Leysath,G., see Werle,E. 198, Lillehei,R.C., see Motsay,G.J. Lluch,S., see Urquilla, P.R. 27, 214 580,600 38 Liacopoulos,P., Halpern,B.N., Lim,R.K.S., Necheles,H., Ni,T. Lockett,M.F., see Bennet,A. Liacopoulos-Briot,A. 443, G. 16,36 465,481 467,495 Limlomwongse,L., Thitha• Loeffier,L.J., Lovenberg, W., Liacopoulos, P., see Halpern, B. pandha, A., So bhon, P. 48, Sjoerdsma,A. 61, 72 N. 422, 430, 467, 471, 473, 56 Loening, K. L., see Blackwood, 491 Lin, T. M., Alphin,R.S., Hender• J.E. 268,287 Liacopoulos-Briot,A., see Lia• son,F.G., Benslay,D.N., Loew,E.R. 253,291,381, 409, copoulos, P. 443,467,495 Chen, K. K. 252,253,291 413,432,439,449,462,463, Liacopoulos-Briot, M., see Lindahl,K.M. 163,172 496 Halpern,B.N. 185,209, Lindberg,S. 139,141,146 Loew, E. R., Chickering, O. 422,430,448,467,473,491 Lindberg,S., Lindell,S.-E., 253,291 Lichtenstein, L. M. 57, 65, 66, Westling,H. 119,126 Loew,E.R., Kaiser,M.E. 381, 72 Lindberg,S., Tornqvist,A. 141, 409, 411, 432, 439, 449, 453, Lichtenstein, L. M., DeBernardo, 146 496 R. 61,66,72 Lindberg,S., see Bjuro, T. 141, Loew,E.R., Kaiser,M.E., More, Lichtenstein, L. M., Margolis, S. 144 V. 182,211, 381, 409, 412, 61,72 Lindell,S.-E., Schayer,R. W. 413,432,449,465,496 Lichtenstein,L. M., Osler,A.G. 118,126 . Loew,E.R., MacMillan,R., 65,72 Lindell,S.-E., Westling,H. 139, Kaiser, M. E. 211, 389, 409, Lichtenstein, L. M., Plaut, M., 146 416,417,432 Henney, c., Gillespie, E. Lindell,S.-E., Westling, H., Loew, E. R., see Achenbach, P. 463,480 440,495 Zederfeldt,B. 110, 126 Lichtenstein, L. M., see Bourne, Lindell,S.-E., see Arborelius,M. Loew,E.R., see Bourque,J.E. H.R. 61,69 16,21,32 390,426 Lichtenstein, L. M., see Gillespie, Lindell,S.-E., see Granerus,G. Loew,E.R., see Last,M.R. 471, E. 59,63,70 141, 143, 145 494 Lidbrink, P., Jonsson, G., Fuxe, Lindell,S.-E., see Helander, Loew, E. R., see Pfeiffer, C. C. 439,499 K. 567,571 e.G. 139,145 Lieberman, M. K., Ovary, Z. Lindell,S.-E., see Lindberg,S. Loew,E.R., see Sherrod,T.R. 467,495,509,511 119,126 409,416,436,462,501 Liebig, R., Bernauer, W., Lindner,E. 449,495 Loew,E.R., see Stone,C.A. Peskar,B.A. 443,460,495 Lindner,E., see Ehrhart,G. 444,502 Liebig, R., Peskar, B., Bernauer, 215,217,246 Lowhagen,O., Arnoldsson, H., W. 460,495 Lindqvist, M., see Carlsson,A. Granerus, G., Wetterqvist, H. Liebig,R., see Bernauer, W. 567,570 142,147 464,482 Lindstrom,K., see Emmelin,N. Lowhagen, 0., Granerus,G., Liedberg,G., see H~kanson,R. 453,486 Wetterqvist,H. 142,147 44,45,55,112,124,444,491 Lineweaver, H., Burk, D. 301, Lomax, P., see Brezenoff, H. E. Lien,E.J., Rodrigues de Miran• 331 568,570 da, J.F., Ariens,E.J. 352, Ling, G. M., see Perry, T. L. Long,S.c., see Diana,). N. 26, 367 133, 147 33 Lien,E.J., Tong,G.L. 363,367 Liomin,G., see Gaertner,H.J. Longerbeam, J. K., see Lillehei, Lien,E.J., see Hansch,C. 334, 529,530,538,556 R.C. 577,581,582,600 358,362,366 Lippert, T. H., Ehe, L. 136, 146 Longo,V.G. 563,567,572 Lightstone,H., Nelson,J.W. Lippert, T. H., Quasthoff, U. Lopez-Rasi,A.M., see Glenn,T. 562,571 136, 138, 146 M. 598 Lilja, B., see Arborelius, M. 16, Lippert, T. H., Waton, N. G. Lordi, N. G., Christian,J. E. 21,32 114,126,134,138,146 227,228,247 Lilja, B., see Hakanson,R. 111, Lipton,M. 566,572 Lorenz,D., see Arnold,H. 446, 112,124 Lish,P.M., Albert,J.R., Peters, 465,481 Lilja, B., see Swenson,E. W. 16, E. L., Allen, L. E. 449, 465, Lorenz, D., see Brock, N. 183, 21,38 466,495 208,446,465,483 Liljedahl,S. 0., see Duner,H. Ush, P. M., Robbins,S. I., Peters, Lorenz, W. 13, 36, 585,600 131,144 E. L. 462, 496 Lorenz, W., Barth,H., Werle,E. Lillehei, R. C. 575,600 Litchfield,1. T., jr., Adams, M. R, 132, 139, 146 Lillehei, R. C., Dietzman, R. H., Goddard,L., Jaeger,M.S., Lorenz, W., Barth, H., Feifel,G., Bloch,J., Manax, W. G. Alonso,L. 386,409,432, Werle,E. 132,139,147 577-581,600 441,465,496 Lorenz, W., Benesch,L., Barth, Lillehei, R. c., Longerbeam,J. K, Litwin,J. 15, 36 H., Matejka, E., Meyer,R., Bloch,J.H., Mannax,W.G. Llorente-de-Carlin, M. c., see Kusche,J., Hutzel, M., Wer• 577,581,582,600 Ochoa,E. 295,331 le,E. 109,126 632 Author Index

Lorenz, W., Doenicke,A., Lundell,L., see Henningsson,S. Majno,G., Palade,G.E. 26,36, Meyer, R., Reimann, H.-J., S.G. 112,125 423,432 Kusche,J., Barth,H., Gee~ Lunsford,e.D., Ward,J.W., Majno,G., Palade,G.E., sing, H., Hutzel,M., Weissen• Pallotta,A.J., Tusing, T. W., Schoefl,G.I. 25,36 bacher,B. 143, 147 Rose,E.K., Murphey,R.S. Majno,G., Shea,S.M., Leven• Lorenz, W., Gerant,M., Werle, 449,454,496 thal, M. 24, 26, 36 E. 119,126 Lurinsky,L.R., see Krauss,S. Majumder,A.K., see Nandi,B. Lorenz, W., Halbach,S., Gerant, 110,126 K. 115,127 M., Werle,E. 111,126 Majumder,A.K., see Subrama• Lorenz,W., Pfleger,K., Werle,E. nian,N. 115,129 111, 126 Maass,B., see Busch,E. 471, Makhlouf,G.M., McManus,J. Lorenz, W., Schauer, A., Heit• 483 P.A., Card,W.I. 46,56 land,St., Calvoer,R., Werle, MacDonald,A.D., Woolfe,G. Makovsky,A.J., see Tislow,R. E. 139,147 585-587,600 409,436,532,559 Lorenz, W., Seidel, W., Doe• MacGregor,A.G., Wood"D.R. Makovsky,E., see Spoerlein,M. nicke,A., Tauber,R., Rei• 471,496 T. 450,501 mann,H.-J., Uhlig,R., Mann, Macha, F., see Knobloch,E. Malaviya,D., see Altura,B. M. G., Dormann, P., Schmal, G., 229,247 27,28,31 Hafner,G., Hamelmann,H., Macht,D.I., Hoffmaster,T. Malawista, S. E., see Gillespie, E. 143,147 562,572 59,63,70 Lorenz, W., see Barth, H. 134, MacIntosh,F.C. 42,56 Malick,J.B., see Barnett,A. 143,444,481 Mackenzie,S., see Marsocci, 562, 567, 570 Lorenz,W., see Gastpar,H. S.F. 228,247 Malik,K., see Dobkin,A.B. 111,124 Mackey,H.K., see Brown,J.H. 566,570 Lorenz, W., see Thermann, M. 444,483 Maling,H. M., Webster, M. E., 2,3,5,7,8, 15, 17,21,38 Macklin, A. W., see Vinegar,R. Williams, M. A., Saul, W., Lorenz,W., see Werle,E. 111, 507,512 Anderson, W., Jr. 508, 510, 129 Maclay, W. P., see Hedges,A. 511 Lorenzo-Lagisquet,J.A., see 566,571 Maling,H.M., Fleisch,J.H., Baez,S. 584, 596 MacMillan,R., see Loew,E.R. Saul, W. F. 27,36 Lorz,E., see Baltzly,R. 227, 211,389,409,416,417,432 Maling, H. M., see Webster, M. E 246 MacNichol,M., see Clowes, 508,512 Losse,H., see Heintz,R. 471, G.H.A.,Jr. 575,597 Malkiel,S., Hargis,B.J. 474, 492 MacQueen,D.M., see Cook, 496 Louwerse, W.J., see Funcke,A. T.J. 421,427 Malkiel, S., see Feinberg,S. M. B.H. 547,556 Magnus,R. 380 381, 389,409, 421,429, 561, Lovejoy,H.B., Feinberg,S.M., Magnusson,R., see Granerus,G. 563,570 Canterbury,E.A. 184,211 131,145 441,442,447,451,454,465, Lovenberg, W., see Engelman, K. Maher,J. P., see Brown,E.A. 487 153,172 185,208 Malone,M.H., see Trottier,R. Lovenberg, W., see Loeffier, L. J. Mahishi,N., see Gerald,M.C. W. 199,213 61,72 204,209 Maloney,J.V., see Chinn,H.I. Lovett, e. A., "Movat,H.Z. 473, Mahishi,N., see Witiak,D.T. 411,427 496 204,214 Maloney, P. P., see Hansch,e. Loynes,J. M., see Durant,G.J. Mahler,D.L., see Teutsch,G. 216,231,240,247 254,289 569,573 Manganiello, V.e., see Stoner,J. Lozowski,S.Z. 27,36 Mahler, R., Intaglietta, M., 64, 73 Lu,F.e., Allmark,M.G. 463, Hugli,T.E., Johnson,A.R. Manian,A. A., see Daly,J. W. 496 24,36 555 Ludden, e. T., see Engelhardt, E. Mahlstedt,I., see Hahn,F. 461, Mann,F.e.,seeEssex,H.E. 13, L. 199,209,543,555 462,490 14,34 Ludden,C. T., see Stone,e.A. Maickel,R.P., see Gerald,M.e. Mann, G., see Lorenz,W. 143, 443,502,507,512,543,559 562,571 147 Ludden,H.C., see Stone,C.A. Maickel, R. P., see J ondorf, W. R. Mann,T.A., see Villani,F.J. 199,213 535,557 200,214,474,503 Luduena, F. P., McKeon, W. B., Maikiel,S., see Feinberg,S.M. Mannaioni,P.F. 9, 10,12,36, Jr. 462,496 513,556 400,432,457, 496 Luduena,F. P., see Lands,A. M. Mainardi, M., Maxwell, V., Mannaioni,P.F., Moroni,F. 180,211,387,409,431 Sturdevant,A. L., Isenberg, 133,147 Ludwig,B.J., see Edelson,I. I. I. 265,291 Mannaioni, P. F., see Fantozzi, 536,555 Majchrowicz,E., see Free, e. A. R. 134, 145, 400, 401, 429, Lulich, K. M., Mitchell, H. W., 116,124 440,487 Sparrow,M. P. 477,496 Majno,G., Gilmore, V., Mannaioni. P. F., see Ledda. F. Lundell,L. 265,291 Leventhal,M. 423, 432 10,35,401,431,458,494 Author Index 633

Mannaioni,P.F., see Moroni,F. Martin,G.R., see Burns,l.J. Maudsley, D. V., Kobayashi, Y., 458,497 549,551,552,555 Kozuka,H., Bedigian,E. Mannax,W.G., see Liliehei,R. Martin,]., see Halpern, B. N. 45, 54, 56, 265, 292 e. 577-582,600 471,491 Maudsley,D.V., see Kobayashi, Manthey,l.A., see Amundson, Martin,L., see Hill,l.H. 445, Y. 45,56,109,112,116,118, M.E. 545,554 492 126, 152, 160, 161, 164, 165, Marco,E.l., see Urquilla,P.R. Martin, P., see Chambon, M. 172 27,38 585-587,596 Mauric,G., see Halpern,B.N. Marcus,S. 439,449,496 Martindale 178, 180-184, 188, 251,290 Mares-Guia, M., Rezende, L.. J r., 190, 193, 195, 196, 198, 199, Mauric,G., see Pasteur Vallery• Diniz,e.R. 301, 331 200,202,204,211 Radot, P. 470,498,499 Mares-Guia, M., see Rezende, L., Mauric, G., see Vallery-Radot,P. Martinek, H., see Woods,l.R. lr. 402,434 389,405,421,436 20,39 Marggraf. W., see Koslowski,L. Mautner,H., Pick,E.P. 13,15, 586,587,599 Martorano,J.J., see Zwemer,R. 36 Margolin,S., see Spoerlein, M. T. L. 468,504 Mautner,H.G. 295,331 450,501 Martres, M.-P., see Baudry, M. Maxwell,G.M., Rencis,V. 469, Margolis,S., see Lichtenstein, L. 110, 119, 123 497 M. 61,72 Marx,G.F., Orkin, L. R. 561, Maxwell, V., see Mainardi, M. Maricq,J., see Morren,H. 185, 563,566,572 265,291 212 Maslinski,e. 122,126 Mayer,R.L. 381,387,409,432, Markley,K., Horakova,Z., Maslinski,e., Krajewska,J. M. 449,455,465,467,497 Smallman,E.T., Beaven,M. 138, 147 Mayer, R. L., Brousseau, D. A. 163, 164, 167, 172, 440, Maslinski,e., Niedzielski,A. 412,432, 474, 497, 589, 590, 496, 585-587, 590, 592, 593, 116,126 591,600 600 Maslinski, e., see Czerwinska, U. Mayer,R.L., Brousseau,D., Marks,I. N., see Barbezat,G.O. 478,486 Eisman, P. e. 439, 465, 497 265,287 Maskinski,e., see Niedzielski,A. Mayer,R.L., Huttrer,e.p., Marois,M., see Morel,F. 2-4, 116,127 Scholz, e. R. 409, 432, 449, 36 Mason, B., see Wilhelm, D. L. 497 Marquis, V.O. 460,496 510,512 Mayer,R. L., see Huttrer,e. P. Marrazzi,A.S., Hart,E., Gilfoil, Massenberg,J.S., see Ridley,P. 180,210,409,430 T. 568,572 T. 265,292 Mayer, R. L., see Rennick, B. Marrazzi, A. S., see Faingold, e. Matejka,E., see Lorenz, W. 453,500 L. 568,570 109,126 Mazel, P., Henderson,J. F. 527, Marriott,H.l.L., see Landau,S. Mathe, A. A., Volicer, L., Puri, S. 558 W. 441, 442, 448, 451, 465, K. 478,496 Mazzei,D., see Melli,G. 456, 494 Mathe,A.A., Yen,S.-S., Sohn, 497 Marsh,D.F., Davis,A.J., Jr. R., Hedqvist, P. 443, 496 Mazzella,H., see Lecomte,]. 409,432 Mathe, A. A., see Yen, S.-S. 443, 459,494 Marsh,E., see Oates,J.A. 140, 444,504 Mazzella,H., see Vanremoor• 141,147 Mathias,A., see Hampson,P. tere,E. 471,503 Marshall,F. D., see Balgooy,J. 268,290 Mazzia, V. D. B., see Altura,B.M. N.A., van 132, 133, 143 Mathieson, D., see Rennick,B. 577-580,595 Marshall,G.R., see Jakschik,B. 453,5()0 Mazzia, V. D. B., see Hershey,S. A. 583, 584, 599 Mathieson,D., see Yonkman,F. G. 577,599 Marshall,P.B. 176,180,183, F. 462,504 Mazzucchi,F., see Cavallini,G. 185, 194, 197, 211, 218, 220, Matoltsy, A. G., Matoltsy, M. 409,427 226,227,247,303,304,331 423,432 McAdam,J.R., Schaefer,F.e. 387-389,398,414,432 Matoltsy, M., see Matoltsy,A. G. 274,292 Marshall, P. B., see Abdel-Galil, 423,432 McArdle,A.H., see Bounos,G. A.A.M. 114,122 Matsui,E., see Imamura,H. 575,596 Marshall, P. B., see Ahmed,A. 540,557 McBride,S., see Smith,G. M. 303,329 Matsumara, Y., Tan,E. M., 564, 565,572 Marshall,P.B., see Cass,R. Vaughan,J. H. 474, 496 McCarty,e.G., Wieland,D.M. 474,484 Matsumura, M., see Hayashi, H. 266,274,275,292 Marshall,R.l., Darby,T.D. 471,492 McCarty,e.G., see Chastain,R. 578,600 Matsuoka, Y., see Ishikawa,E. V. 276,288 Marsland,D., Tilney,L.G., Ill, 125 McCord, e., see Miller, R. L. Hirshfield,M. 63, 72 Mattila, M. J., see Klinge, E. 20, 164, 165, 172 Marsocci, S. F., Mackenzie, S. 35 McCulloch, M. W., Proctor, c.. 228,247 Maudsley, D. V., Kobayashi, Y., Rand,M.J. 462,497 Marson,L. H., see Vaughan,J.R. Bovaird,L., Zeidel,M. 444, McDonald-Gibson, W., see 180,214 496 Greaves,M.W. 506,511 634 Author Index

McDowall,R.J.S. 2,3,5,7,16, Meier,R., see Hochrein,M. 13, Metysova,J., see Votava,Z. 36 18,34 201,214 McEachern,J. 563,572 Meier,R., see Tripod,J. 7-9, Metyzova-Sramkova,J., see McFadden,H. W., Jr., see Welsh, 11, 12,38 Protiva,M. 201,212 J.D. 471,503 Meineke,F., see Friedberg,K.D. Metzger, H., see Kulczicky,A., McGavack,T.H., Drekter,J.J., 452,488 Jr. 60,61,71 Schutzer,S., Heisler,A. Melander,B., see Ka1l6s,P. Metzger, H., see Sullivan,A.L. 513,516,518,523,524,558 474,493 61,73 McGavack,T.H., Elias,H., Mellander, S., Johansson, B. Meyer,H.H. 215,247 Boyd,L.J. 390, 413, 416, 580,581,600 Meyer,K.H., Hemmi,H. 215, 421,433 Melli, G., Folli,G., Mazzei, D., 247 McGavack,T.H., Shearman,A. Vitolo, E., Sacchi,A. 456, Meyer,R., see Lorenz, W. 109, H., Weissberg,J., Fucks,A. 497 126, 143, 147 M., Schulman, P. M., Drek• Melmon,K.L.,see Bourne,H.R. Meyers,G.L., see Chiesa,A. ter,l.1. 183,211 61,69 469,484 McGavack, T. H., see Elias, H. Melmon,K.L., see Miller,R.L. Michaelson, I. A., CotTman, P. Z. 421,428 164, 165, 172 151,172 McGavack,T.H., see Gelvin,E. Melmon, K. L., see Reichgott, M. Michaelson,I.A., see Conney,A. P. 513,516,556 J. 583,601 H. 529, 550, 551, 555, 563, McGavack, T. H., see Harris,R. Melville,K.1. 175,211 570 416,430 Melville, K.1., see Francis, L. E. Michele,S., see Miller,R. L. McGitT,J.e., see Vane,J.R. 369, 370, 371, 374, 379, 455, 164, 165, 172 584,602 488 Midtvedt, T., see Trippestad,A. McGinty,D.A., see Glazko,A.J. Melville, K.1., see Kovacs, B. A. 575,602 514,518-520,556 370-375,380 Mielens,Z.E., Ferguson,E. W., McHenry,E.W., see Best,e.H. Melville, K. I., see Lefcort, M. Rosenberg,F.J. 466,473, 1,32 373-375,378,380 474,497 McIntire,F.e. 151,172,281, Melville, K. I., see Stotland, M. Miescher, K., Klarer, W. 181, 292 370,373,374,378,380 212 McKeon,W.B., Jr., see Ludue• Melvin, I. S., see Ts'o,P.O.P. Mietzsch,F. 204,212 na,F.P.462,496 279,293 Mighton,H.R., see Titus,E.O. McKnight,R.C., see Jakschik,B. Mene,G., see Biozzi,G. 423, 521,559 A. 583, 584, 599 426 Miles,A.A., Miles,E.M. 422, McLaurin,]. W., Shipman, W. F., Mene,G., see Ovary,Z. 423, 423,433 Kirkley,D.E.,Jr. 411,433 433 Miles,A.A., Wilhelm,D.L. McLean, M., see Josephson, 1. Mene,G., see Serafini, U. 421, 422,433 401,431 436 Miles,E.M., see Miles,A.A. McMahon,R.E., Sullivan,H.R. Mengel,J., see Chakrin,L.W. 422,423,433 521,558 440,484 Milin,R., see Stern,P. 466,501 McManus,J. P.A., see Makh• Mengoli,L.R., Wax,S. D., Webb, Miller,D., see Kamm,J.J. 533, louf,G.M. 46,56 W.R. 581,600 557 McMurray,W.e., see Lardy,H. Menkin, V. 422, 433, 575, 600 Miller,D.A., see Farrington,G. A. 101,108 Menninger,R. P., see Baker,C. H. 575,598 McNamee,J.E., Grodins,F.S. H. 19,22,32 Miller,G.E., see Arbesman,C.E. 26,27,36 Menon,M.K., Clark, W.G., 421,425,442,446,481 McNeil,J.R. 576,583,600 Aures,D. 116, 127 Miller,I.T., see Thompson,M. McNeill,J.H., Muschek,L.D. Menon, M. K., see Aures, D. H. 265,293 9,36,401,433 123 Miller,J., Fishman,A. 543,558 McNeill,J.H., Verma,S.C. Mentz, P., see Forster, W. 460, Miller,L.D., see Cavallito,C.J. 9,12,36,400,401,433,440, 488 532,555 458,459,497 Merriman, R. L., see Hanna, P. E. Miller, P., see Church, M. K. McNeill,J.H., see Verma,S.e. 204,210 475,485 441,459,503 Mertens,E., see Forman,C. Miller,R.L., McCord,C., McPeek, B., see Smith,G.M. 409,429 Michele,S., Bourne,H.R., 564,565,572 Messina,E.J., Weiner,R., Ka- Melmon,K.L. 164, 165, McQueen,E.G. 505,511 ley,G. 23,36 172 Medina,M.A., Landez,J.H., Messmer, K. 578,600 Millican, e. R., Rhodes, e. J. Foster,L.L. 117, 127 Metys,J., Metysova,J. 202,211 590,592,600 Mehlman, B., see Vick,J.A. 60, Metys,J., see Metysova,J. 200, Mills,J. 187,212 74,585-587,602 201,202,211,212 Milton-Thompson,G.l., Wil• Meier,R., Bucher,K. 381,387, Metysova,J., Metys,J., Votava, liams, J. G., Jenkins, D. J. A., 388,409,412,417,433 Z. 200-202,211,212 Misiewicz,J.J. 265, 292 442,449,451,455,462,471, Metysova,J., see Metys,J. 202, Minard, D., see Rosenthal,S.R. 497 211 405,417,435 Author Index 635

Mishra,B.N., Sinha,Y.K. 444, Mongar,J.L., see Garland,L.G. Morrison, G. A., see Eliel, E. L. 497 64, 70 271,289 Misiewicz,]. J., see Milton• Mongar,J. L., see Schild,H. O. Mota,l. 57, 72, 106, 108, 412, Thompson,G.J. 265,292 398,435,454,501 433,442,443,471-473,497, Mitchell, H. W., see Lulich, K. M. Moon,V.H. 575,584,600 510,511,585,586,588,591, 477,496 Moore,T.e. 116,127 600 Mitchell,R.e. 266,270,280, Moore, T. e., Chang,]. 116, Mota,l., Dias da Silva, W. 443, 292 127 497 Mitchell, R. e., see Critchley, S. Moore, T. e., Cleveland, R. J., Mota,l., Vugman,1. 443,497 R. 271,273,288 Thompson,D. P., Nelson,R. Mota,I., see Becker,E. L. 443, Mitchell,R.E., see Abramson,D. J. 143, 147 444, 473,481 I. 6,7,30 Moore, T. e., Lemmi, e. A. E., Mota,I., see Humphrey,J.H. Mitchell,R. G. 119, 127 Orlando, J. e., Pinkerton, W. 467,492 Mitchell,R.G., Thom,H., Ri• 110,127 Motley, V. A., see Swineford,O., chardsson,1. E. 140, 142, Moore, T. e., Schayer,R. W. Jr. 466,502 147 110, 116, 127 Mitchell,R.G., see Porter,J.F. Moore, T. e., Thompson, D. P. Motsay,G.J., Alho,A.V., Dietz• 23,37, 139, 142, 147 Glasock,R.J. 143, 147 man, R. H., Schultz, L. S., Mitchell,R.G., see Thom,H. Moore,V., see Loew,E.R. 182, Romero, L. H., Lillehei, R. e. 140, 142, 149 211,381,409,412,413,432, 580,600 Mitoma, e., see Johnson, H. L. 449,465,496 Moussa et al. 139 115, 120, 125 Moraes, e. R. de, see Lette, M. P. Moussatche, H. 95, 108 Mittermayer, Ch., see Hagedorn, 478,495 Moussatche, H., Prouvost- M. 461,490 Moran,J.F., Triggle,e.R., Danon,A. 93,108 Mitze,R., see Hahn,F. 441, Triggle, D. J. 325, 331 Moussatche, H., see Prouvost• 445, 448, 451, 454, 460, 461, Moran,J.F., Triggle,D.J. 295, Danon,A. 93,108 463,468,472,490 320,324,325,331 Movat,H.Z., DiLorenzo,N.L., Mitze, R., see Kretzschmar, R. Moran,N.e. 578, (jOO Taichman,N.S., Berger,S., 468,493 Moran, N . e., U vnas, B., Stein,H. 467,498 Mitze, U., see Giertz,H. 453, Westerholm,B. 58, 72, 78, Movat, H. Z., see Lovett, e. A. 464,489 91 473,496 Miya,T.S., see Tobia,A.J. 23, Moran,N.e., see Johnson,A.R. Movat,H.Z., see Taichman,N. 38 58,61,71,78,79,90,91,105, S. 467,502 Miyoshi,H., see Hayashi,H. 106, 107 Miilke,G., see Hahn,F. 471, 471,492 Moran, N.e., see Sandusky,e. B. 490 Mizgiert, W. K., see Kosmicki, B. 60,73 Miiller,E.A., Salomon,H., P. 585, 587, 599 Morel,Ch.J., see Stoll, W.G. Zuelzer, 14, 15,36 Mizoguchi, H., see Johnson, e. L. 186,213 Miiller,F.W., see Frimmer,M. 459,493 Morel,F., Marois,M. 2-4,36 422,423,429 Morijama, T., see Ishikawa, E. Mock,J.E., Rickels,K., Yee,R. Mueller, L., see Lagunoff, D. 111,125 566,572 89.91 Morimoto, M. 18,36 Mohammed,F.H., see Barer,G. Miiller-Eberhard,H.1., see Morley,J., see Williams, T.J. R. 477,481 Cochrane, e. G. 60, 70 506,512 Moisa, L., Pavalescu, M., Miiller-Eberhard,H.J., see Moroni, F., Ledda, F., Fantozzi, Dobre,A. 508,511 Johnson, A. R. 60, 71, 78, Mole, K. H., Shepherd, D. M. R., Mugelli,A., Mannaioni, 90 P. F. 458,497 116,117,127,467,497 Mugelli,A., see Fantozzi,R. Molinoff, P. B., Landsberg, L., Moroni, F., see Fantozzi, R. 400, 401, 429 Axelrod,1. 153,172 134,145,440,487 Mugelli,A., see Ledda,F. 10, Molls, M., Bernauer, W. 464, Moroni,F., see Ledda,F. 10, 35,401,431,458,494 497 35,401,431,458,494 Mugelli,A., see Moroni,F. 458, Moncada,S., Ferreira,S. H., Moroni, F., see Mannaioni, P. F. 497 Vane,J.R. 506,507,511 133,147 Muhi-Eldeen, Z., see Gerald, M. Moncada,S., see Ferreira,S. H. Morren, H., Trolin, S., Denayer, e. 204,209 507,511 R .. Grivsky,E., Maricq,1. Muhi-Eldeen,Z., see Witiak,D. Mongar,J. L., Perera,A. V. 98, 185,212 T. 204,214 108 Morris. H. e., see Wells,1.A. Muir,R. M., see Hansch,e. Mongar,J.L., Schild,H.O. 65, 251, 293, 389, 409, 412,437, 216,231,240,247 72,93,96,108,441,497 469,503,591,602 Mukhopadhyay,A., see Seth,S. Mongar,J.L., Svec,P. 63,72 Morris,1. R., see Glenn, T. M. D.S. 370,380 Mongar,J. L., Svec, P., Fore• 598 Mulder, D., see Funcke,A.B.H. man,J.e. 65,72 Morrison, D. e., Roser,J., Coch• 201,209 Mongar,1.L., see Foreman,J.e. rane,e.G., Henson,P.M. Mulder,D.S., see Bounos,G. 58. 63-65. 70 59.71 575.50(; 636 Author Index

Mulder,J. L., see Cort,J. H. Narrod,S.A., Wilk,A.L., King, Neter,E., see Arbesman,e.E. 579,597 e.T.G. 526,527,531,558 468,481 Mungall,I.P.F., see Barer,G.R. Narrod,S.A, see King,e.T.G. Netter,K.F., see Kahl,G.-F. 477,481 526,527,558 98,107 Munoz,e., see Goldstein,L. Nath,R., see Bhargava,K.P. Netter, K. J., Bodenschatz, K. 568,571 475,482 134,147,444,498 Muraoka,S., see Yamasaki,H. Nauta,W.Th., Bultsma,T., Neuwelt,F., Levinson,S.O., 93,108 Rekker,R.F. Timmerman, Necheles, H. 5,36 Murat,M., see Pellerat,J. 442, H. 232,247 Neveu,T., see Halpern,B.N. 499 Nauta,W.Th., Rekker,R.F., 475,491 Murayama,K., see Woods,J.R., 388,398 Newball, H. H., see Webster, M. Jr. 469,503 Nauta, W. Th., Rekker,R. F., E. 163,164,167,173 Muren,A, see Emmelin, W. Harms,AF. 227,248,256, Newman,J.H., see Bruce,R.B. 401,428 292,402,404,419,433 535,555 Muren,A., see Emmlin,N. 463, Nauta,W.Th., see Bijlsma,U.G. Newman-Taylor,AJ., see 487 183,208 Hedges,A. 566,571 Murer,E.H., Hellem,A.M., Nauta, W. Th., see DeRoos,A M Ni,T.G., see Lim,R.K.S. 16, Rozenberg, M. e. 68, 72 522,555 36 Murphey,R.S., see Lunsford,e. Nauta, W.Th., see Funcke,A.B. Nicholls, P.J., see Lewis,AJ. D. 449, 454,496 H. 201,209, 547, 556 111,126,132-134,146 Murphree, H. B., see Goldstein, Nickerson, M. 299, 320, 324, Nauta,W.Th., see Harms,A.F. 562,563,565,566,571 331, 390, 433, 578, 582, 593, L. 215-217, 219-222, 224, 227, Murphy,G.E., see Becker,e.G. 229, 232, 236, 242, 244, 245, 600 26,32 Nickerson, M., see Cort,J. H. 247, 387,430 Muschaweck,R., see Hirsch,E. 579,597 463,492 Nauta,W.Th., see Hespe,W. Nicot,G., see Vasseur,B. 372, Muschek,L.D., see McNeill,J. 521-523, 547,557 374,380 H. 9,36, 401, 433 Nauta, W.Th., see Rekker,R.F. Niedzielski, A., Maskinski, e. Mustard,J.F., Packham,M.A. 183,212,216,228,229,234, 116,127 68, 72 236,248, 387, 388, 390, 397, Niedzielski,A., see Maslinski,C. Mustard,J.F., see Nishizawa,E. 398,402-404,413-416.434 116,126 E. 68,72 Nauta, W. Th., see Roos,A. M. de Niehoff,E., see Teschendorf,H. 227,229,248,249 J. 468,502 Nauta, W. Th., see Roozemond, Nielsen,K.C., Owman,Ch. Nadela,S.M., see Kessler,E. R. e. 548, 558 27,36 584,599 Nauta, W. Th., see Van der Stelt, Nielsen, P. H., see Jensen, K. Nagasawa,J., see Douglas, W. W. 106, 107 C. 199,200,214,234,236, 268,290 249 Niemann,e., Hays,J.T. 256, Nagel,E., see Bartosch,R. 386, Nauta,W.Th., see Waringa,e. 292 425 G. 216,225,233,237,238, Nagler,A.L., Levenson,S.M. Niemegeers,e.J.E., see Awou• 575,600 249 ters, F. 446,481 Navert,H., Flock,E. V., Tyce,G. Nagler,A.L.,seeJanoff,A 576, Niemegeers,C.J.E., see Janssen, M., Code,e.F. 133,147 599 P.A.J. 562,571 Necheles,H., see Lim,R.K.S. Nagler,M.E., see Copenhaver, Niemeyer,J., see Barth,H. 134, J.H.,Jr. 469,470,485 16,36 143, 444,481 Necheles, H., see Neuwelt,F. Nakajima, T., Sano,J. 139, 147 Nies,A.S., see Ellis,E. F. 460, 5,36 Nakajima,T., Wolfgram, F., 486 Needleman, P., see Jakschik, B. Clark,W.G. 133,147 Nikaitani,D., see Hansch,e. A. 583, 584, 599 Nakamura, W., see Hosoda,S. 334, 358, 366 110,125 Nelemans,F., see Vanremoorte• Nimptsch, P., see Bernauer, W. Nakazawa, K. 547,558 re,E. 471,503 459,472,482 Nandi,B.K., Subramanian,N., Nelson,e.T., see Fox,e.L., Jr. Nishiyama,R. 442,469,498 Majumder,A.K., Chatterjee, 475,488 Nishizawa,E.E., Mustard,J.F. I.B. 115,127 Nelson,J.A., see Huebner,C.F. 68,72 Nandi, B. K., see Subramanian, 202,210 Nissen,J., see Diamant,B. 104, N. 115,129 Nelson,J. W., see Lightstone,H. 107 Naranjo, E. B. de, see Naranjo, P. 562,571 Nivard,R.J.F., see Ellenbroek, 390,414-416,418,419,433 Nelson,R.J., see Moore,T.e. B. W. J. 352, 366 443,449,462,471,498 143,147 Nobili, C., see Brown,E.A. Naranjo, P. 441,444,498 Nelson, W.A., see Landau,S. W. 185,208 Naranjo, P., Naranjo, E. B. de 417,418,431,443,463,494 Nobin,A, see Bjorklund,A. 390,414-416,418,419,433 Nemir,P., Jr., see Ahmadi,A. 121, 123 443,449,462,471,498 575,594 Noble,R.L., see Cutting,W.e. Narayana,B. 14,36 Neter,E. 498 16,33 Author Index 637

Noell,W.K., Chinn,H.I., O'Connor, N. E., see Gazzaniga, Orkin,L.R., see Baez,S. 584, Haberer,C. 564-567, 572 A. B. 575, 598 585,596 Norcross, N. L., see Zarkower, Oda, T., 457,459,498 Orkin,L.R., see Hershey,S.G. A. 137,150 Oelz,O., see ElIis,E.F. 460,486 577,578,599 Norinder,B., Granerus,G., Offermeier,J., Van den Brink, Orkin,L.R., see Marx,G.F. Wetterqvist,H. 143, 147 F.G. 365,367 561, 563, 566,572 Norinder,B., Wetterqvist,H. Oh-Ishi,S., see Webster,M.E. Orlando,1. c., see Moore, T. C. 135 163, 164, 167, 173 110,127 Nordqvist, P. 420,433 Ohmoto, M., see Ishida, Y. Orlow,S.M., see Guschin,I.S. Nordqvist, P., see Biininy,E. 375, 377, 379 79,90 417,420,425 Okada, M., see Fukuda, T. 575, Oronsky,AL., see Perper,R.J. Nom,S., see Diamant,B. 104, 598 474, 475, 499 107 Okada,T., see Imamura,H. Orr,T.S.G., Hall,D.E., Allison, Nornes,H., see Dohlen,H. 141, 540,557 AC. 59,72 144 "Okamoto, Y., see Brown,H.C. Orr,T.S.G., Hall,D.E., Norryd,C., see Dencker,H. 229,246 Gwilliam,J.M., Cox,J.S.G. 112,123, 139, 144 Okamura, T., Shiina, Y. 399, 64,72 433,456,498 Northover,A. M. 26,36 Ortner, M.J., see Read, G. W. Okino, L., see Reis, M. L. 423, 59,73 Northover, A. M., N orthover, B. 434 Orton, T. c., see Anderson, J. 24, 26, 28, 36 Okpako,D.T. 15, 21, 37, 453, M. W. 547,554 Northover,B.J., see Northover, 454,498 Orville-Thomas, W.J., see AM. 24, 26, 28, 36 Okuma,T., Kawahara,R., Jones, W.J. 274,290 Norton,R.C., see Brown,E.A. Umezawa,Y., Kashiwagi,T. Orzechowski,R.F., see Smith, 185,208 562,566,572 R.G. 562,572 Nosal,R., Slorach,S.A, Uvniis, Olesky,]., see Konturek,S.J. Osawa, Y. 16,37 B. 88,91 50, 56, 265, 291 Oscarson,J., see Hiikanson,R. Novilkovil,J., see Cort,J. H. Ollmann,J.E., see Witiak,D.T. 45,55 579,597 204,214 Oshima,H., see Ishida, Y. Novis,B., see Barbezat,G.O. Olsen,N., see Diamant,B. 104, 375-377,379 265,287 107 Osler,AG., Siraganian,R.P. Novotny,]., see Aborg,C.-H. Olson,A.C., see Ts'o,P.O.P. 68,72 86,90 279,293 Osler,AG., see Levy,D.A. 60, Nowak,H., see Bauer,G. 546, Olson, K.J., see Van der Brook, 71,72 554 M.J.197,214,388,437,450, Osler,A G., see Lichtenstein, Nueten,J.M. van 217 455,502 L.M. 65,72 Nueten,J. M. van, see Schaper, O'Neill, P.J., Pati!, P. N. 416, Ovary,Z. 412,433,467,471, W.K.A. 531,558 433 473,498 Nyhus, L. M., see Schumer, W. Oniwinde,A.B., see Woodruff, Ovary,Z., Bier,O.G. 412,433, 577, 581,601 G.N. 133,150 466,467,498 Nys,G.G., Rekker,RF. 234, Onoda,K.-I., see Kato,R. 521, Ovary,Z., Biozzy, G., Mene,G. 240,248 557 423,433 Nys,G.G., see Harms,A.F. Oosthuisen, see Lamson, P. D. Ovary,Z., see Biozzi,G. 423, 217 3,4,17,35 426 Nys,G.G., see Rekker,R.F. Opferkuch, W., see Giertz,H. Ovary,Z., see Lieberman, M. K. 234,240,248 453,454,489 467,495,509,511 Oppenheim,J.J., see Hook, Overman,J.R., see Way,E.L. W.A. 58,71 514,516,518,559 Oates,J.A., Marsh,E., Oppenheimer,E., see Yonkman, Overton,E. 215,248 Sjoerdsma,A 140,141,147 F. F. 453,469,504 Owen,D.A.A., see B1ack,J. W. Oates,J.A., see Ellis,E.F. 460, Orange,R. P. 59,72 5,6,32,469,482 486 Orange,R. P., Kaliner,M.A., Owen,D.A.A, see Ober,R.E., see Blackburn,C.E. Austen, K. F. 167, 172 Brimblecombe,R. W. 4, 32 520,554 Orange,R. P., Kaliner, M.A., Owen,D.A.A, see Flynn,S.B. Oberdorf, A., see Hahn,F. 468, LaRaia, P. J., Austen, K. F. 477,488 490 61,67,72 Owen,D.A.A., see Parsons, O'Brien,J.R. 68,72 Orange,R.P., see Ishizaka,T. M. E. 3-5, 21, 37, 440, 469, Obtulowicz, W., see Konturek, 61, 71 498 S.J. 265,291 Orange,R. P., see Kaliner,M.A. Owen, P.J., see Brigham, K. L. Ochoa, E., L1orente-de-Carlin, 64,67,71 476,483 M.C., De Robertis,E. 295, Orehek,J., Douglas,J.S., Owman,C., see Hakanson,R 331 Bouhuys,A. 509,511 Ill, 112,124 Ochoa,E., see De Robertis,E. Orkin,L.R, see Altura,B. M. Owman,Ch., see Edvinsson,L. 295,330 27,28,31 24,27,33 638 Author Index

Owman,Ch., see Nielsen,K.e. Parratt,J.R. 457,498 Paulet,G., see Hermann,H. 27,36 Parratt,J.R., Sturgess,R. M. 469,492,589,590,599 Ozerov,R.P., see Rannev,N.V. 584,601 Pauling,L. 262,292 266,274,277,292 Parrot,J.L. 93, 108, 389, 405, Pavalescu, M., see Moisa, L. 421,434,462,498 508,511 Parrot,J.-L., Laborde,C. 82, Payne,N.A., see Ellis,E.F. Paasonen, M. K. 462, 498 91,467,498 460,486 Packham,M.A., see Mustard, Parrot,J.L., Lefebvre,J. 389, Peach,M.J., Cline, W.H., J.F. 68,72 421,434 Watts,D.J. 583,601 Pearlman,D.S., Waton,N.G. Padawer,J. 58,73,78,91 Parrot,J.-L., see Ungar,G. 110, 127 Page, I. H. 583,600 179,214,389,436 Pagel, W., see Kallos, P. 406, Peat, G., see Harrison, V.e. Parrot,J.-L., see Vasseur, B. 141, 145 431,465,493 372, 374, 380 Palade,G.E.,see Majno,G. 26, Peat,S., see Daly,l.B.de 386, Parsons,M., see Ferreira,S.H. 36,423,432 427 507,511 Palazzo, S., see Caronna, G. Peck,A.W., Fowle,A.S., Bye,e. 201,208 Parsons, M. E., 217, 254, 264, 569,572 Palenik,G.J., see Clark,G.R. 281,292 Pedersoll, W. M. 477, 499 182,208 Parsons, M. E., Blakemore, R. e., Peeters,G., see Vercauteren,R. Palenik, G. 1., see Veidis, M. V. Durant,G.J., Ganellin,e.R., 369,380 182,214 Rasmussen,A.e. 257,292 Peets, E. A., Jackson, M., Palit,G., see Bhargava,K. P. Parsons,M.E.,Owen,D.A.A. Symchowicz,S. 533, 558 475,482 3-5,21,37,440,469,498 Peets,E.A., Weinstein,R., Palkovits, M., Brownstein, M., Parsons,M. E., see Black,J. W. Hillard, W., Symchowicz, S. Saavedra, J. M., Axelrod, J . 3, 5, 6, 12, 24, 32,49, 50, 55, 533,558 172 252,259, 260, 263-265, 281, Pelczarska,A. 467, 499 Palkovits, M., see Brownstein, 287, 376, 379, 386, 392, 393, Pelczarska, A. B., M. 568,570 401, 421, 426, 440, 458, 469, Roszkowski,A. P. 468, 499 Palkovits, M., see Saavedra,J. M. 482, 569, 570 Pelikan,Z., deVries,K. 509, 511 153,173 Parsons, M. E., see Pellerat,J., Murat, M. 442,499 Pallin, I. M., see Lear, E. 566, Brimblecombe,R. W. 4,32, Pellet, E., see Yonkman,F.F. 571 265,283,285,288 Pallotta, A. J., see Lunsford, C. D. 453,469,504 Parsons,M.E., see Durant,G.1. Pelletier,G. 373,374,376,377, 449,454,496 255,256,278,289 Palm, D., see Holtz,P. 463,492 380 Parulkar,A.P., see Casy,A.F. P'An,S. Y., Gardocki,J. F., Pelletier,G., Desjardins,L. Reilly,J.e. 185,212,388, 187,208 374--376, 378, 380 433 Pascal, J. P., Vaysse, N., Pelletier, G., Kovacs,B.A., Panigel, M. 20, 37 Boucard,J. P., Laval,J., Rose,B. 374,380 Panse, M. V., Dutta, N. K. 586, Ribet,A. 17,37 Pelletier, G., Laflamme,G. 587,600 Pascaud,X. B., Devys,M. M., 370,373,374,376,380 Papa, D., see Sperber,N. 183, Errard,D.J. 510,511 Pelletier, G., Lessard, P., 184,193,194,213,532,559 Pasteur Vallery-Radot, P., Laflamme,G. 374, 375, Pappenheimer,J.R., see Bovet,D., Mauric,G., 377,378,380 Landis,E.M. 24,35 Holtzer,A. 470,498,499 Pelletier, G., Pouliot,R., Parfentjev,I.A. 474, 498 Pasteur Vallery-Radot,P., Delagrave,J. 375,380 Parikh, I., see Cuatrecasas,P.G. Halpern,B.N., Holtzer,A. Pelletier,G., see Gauthier,P. 295,330 442,499 370,379 Parikh,J.R., see Dailey,R.E. Pasteur Vallery-Radot,P., Pelletier, G., see Kovacs,B.A. 515,516,555 Mauric,G., Halpern,B. N., 370,37~378,380,455,493 Parish, W.E., Hall,L. W., Holtzer,A. 470,499 Pelletier, G., see Vasseur,B. 375 Coombs,R.R.A. 452,498 Patel,D., see Barouh, V. 184, PenttiHi,O., see Klinge,E. 20, Park,J., see Carter,D.e. 265, 207 35 288 Patil,P.N., see O'Neill,P.J. Pepper,E.S. 269,270,274,277, Park, V. A., see Dowell, e. R. 416,433 292 142,144 Perera,A. V., see Mongar.J. L.. Paton,W.D.M. 326,328,331, Parker, e. W., see Sullivan,T.J. 98,108 403,434,441,455,499 58, 61-{i4, 73 Perez del Castillo, C., see Parker,K. L., see Sullivan, T.J. Paton,W.D.M., Rang,H.P. Halpern,B. N. 471,473, 61~4, 73 300,326,331 491 Parker,R.B., Waud,D.R. 325, Paton,W.D.M., Waud,D.R. Periyasami,S. M., see Jaya• 331,394,397,433 296,300,326,331 sundar,S. 370, 373, 375- Parker,R. B., see Waud,D. R. Patterson, G. e., see Duif,F. 377,379 325,332,393,394,396,437 422,428 Perkow, W. 229, 230, 248 Author Index 639

Periman,E. 513, 514, 523, 524, Phillips,M.T., see Lagunoff,D. Porter,J.F., Mitchell,R.G. 23, 558 75,78,82,85,91,93,107 37, 139, 142, 147 Pernow,B., see Duner,H. 131, Phillis,J. W., Tebecis,A. K., Portnoy, B., see Engelman, K. 144,370,371,374,379 York,D.H. 568,572 153,172 Perper,R.J., Oronsky,A. L., Pick, E. P., see Mautner, H. 13, Posner,H.S., Graves, A., King, Blancuzzi, V. 474, 475, 499 15,36 C T. G., Wilk,A. L. 529, Perrauit,M., see Celice,J. 389, Pickett, R. D., see Anderson, 558 M. W. 547,554 427 Potter, M. A., see Dunn, Thelma Pierce,L., Hayashi,M. 262, Perrier,C V., Griessen, M. B. 167,172 458,499 292 Pietra,G.G., Szidon,J. P., Potter,R., see Spink, W. W. Perriere,J. P., see Duchene• 585-587,602 Marullaz, P. 409,428 Leventhal, M. M., Fishman, A. P. 26,37 Pouliot. R" see Pelletier, G. Perrin,G., see Halpern,B.N. Pillemer,L., see Frank,E. 575, 375,380 417,430,442,491 598 Poulsen, T. 444, 499 Perry,T.L., Hansen,S., Foulks, Pinkerton,W., see Moore,T.C Powell,J.R., Brody,M.J. 1,3, J.G., Ling,G.M. 133, 147 110,127 6,16,24,25,37,401,422,434, Perry,W.L.M., see Brand,J.l. Piper, P. J. 453, 499 469,499,506,511 411,426 Piper,P.l., Collier,H.O.J., Praagh, I. G. van, see Harkins, Perry, W. L. M., see Vane,J.R. 463, 499 J. L. 566,571 Brocklehurst, W.E. 473, Piper,P.J., see Collier,H.O.J. Prabhakar, M. C, see Seth, 483 411,427 S. D.S. 370,380 Peskar,B.A., see Liebig,R. Pitts,J.E., see Bruce,R.B. 535, Prado, M. L. M., see Vugman, I. 443,460,495 555 442,503 Peters,CA., see Wahner,W.H. Plati,J.T., Wenner,W. 203, Prager,D.J., see Feigen,G.A. 197,214 212 457,487 Peters, E. L., see Brown, B. B. Plaut, M., see Lichtenstein, L. M. Prager,D.J., see Vurek,G.G. 387,389,409,426 440,495 459,503 Plazas, S. F., see De Robertis, E. Peters, E. L., see Lish, P. M. Preuner,R. 411,434, 465, 499 449,462,465,466,495 295,330 Price, E., see Tompa,A.S. 269, Plester,D., see Buchholz,R. Peters,G.A., see Wakim,K.G. 293 462,483 19,39 Prins, H., see Hespe, W. 547, Petersen, P. V., see Weidmann, Plester, D., see Hahn, F. 448, 490 557 H. 562,567,573 Pritzl, P., see Lagunoff, D. 89, Peterson, C 104, 108 Plummer,A.J., see Barrett, W. E. 91 Peterson, C, Diamant, B. 104, 446,481 Proctor, C, see McCulloch, 108 Pocha, P., see Casy,A. F. 186, M. W. 462,497 Peterson,J., see Zucker, M. B. 187,208 Prohle,F., see Hahn,F. 441, 68,74 Poch, G., Kukovetz, W. R. 9,37 490 Petracra,A. E., see Blackwood, poch,G., Kukovetz, W.R., Protiva,M. 175,181,198,201, J.E. 268,287 Scholtz,N. 9, 12, 37, 401, 202,212,215,217,248 Petri,G., see Karady,S. 377, 434, 458, 499 Protiva, M., Borovicka, M., 379 poch,G., see Kukovetz,W.R. Hach, V., Votava,Z., Pettit,F. H., see Ziegler, D. M. 401,431,463,494 Metysova-Sramkova,J., 521,560 Poisner,A. M., Bernstein,J. Horakova,Z. 201,212 Pfeiffer,CC 352,353,355,367 63,73 Protiva, M., Rajsner, M., Pfeiffer,CC, Loew,E.R. 439, Polet,H., see Delaunois,A.L. Adlerova,E., Seidlova, V., 499 5, 7, 8, 15,33 Vejdelek,Z.l. 201,212 Pfeiffer, C C, see Goldstein, L. Pollard, H., Bischoff,S., Protiva,M., Votava,Z. 220, 562, 563, 565, 566, 568, 571 Schwartz,] .-C 110, 120, 248 Pfleger, K., see Lorenz, W. 111, 127 Protiva,M., see Borovicka, M. 126 Pollard, H., see Schwartz,J.-e. 201,208 Phair,J. P., Eisenfeld,A.J., 119,129, 133,148 Protiva,M., see Jilek,J.O. 201, Levine, R. l., Kantor, F. S. Polner,A.A., see Ado,A.D. 211 467,499 468,480 Protiva,M., see Knobloch,E. Philippot,E., see Chariier,R. Pomykacek,l., see Jilek,l.O. 229,247 398,427,442,484 201,211 Prout, K., see Critchley,S. R. Philipszoon,A.J. 411,434 Popielsk i, L. 41,56 271,273,288 Phillips,A., see Kuntzman,R. Port,G.N.J., see Ganellin,CR. Prout, K., see Kamenar, B. 521,527,529,558 279,289 271,290 Phillips,E.A., see Goadby,R. Porter,Ce., Arison,B.H., Prouvost-Danon,A., 15,21,34 Gruber, V. F., Titus, D. c., Moussatche,H. 93, 108 Phillips,J., see Albert,A. 267, Vendenheuvel, W.J.A. 543, Prouvost-Danon,A., see 287 544,558 Moussatche, H. 93, 108 640 Author Index

Prouvost-Danon,A., see Vaz, Reddin,J.L., Starzecki,B., Reinhardt,D., Wagner,J., N.M. 57,74 Spink, W. W. 585, 587, 601 Schumann,H.J. 12, 37, Prox,A., see Breyer, U. 530, Redmond,R.F., see Chinn,H.l. 401, 434, 440, 457, 458, 499 554 411,427 Reinhardt, D., Wiemann,H.M., Pruyn,F.J., see Lange, W.E. Reed,J.D., Smy,J.R., Venables, SchUmann,H.J. 440, 457, 532,558 e.W., Harris,D.W. 21,37, 458,500 Puri,S. K., see Mathe,A.A. 49,50,53,56 Reinhardt, D., see Wagner,J. 47R. 496 Reed,J.D., see Harris,D. 264, 27,29,39 Pustkin, E., see Goldman, B. 290 Reis, M. L., Okino, L., Rocha e 543,556 Reed,J. D., see Thompson, M. H. Silva, M. 423,434 265,293 Reite,O.B. 23,37,132,147 QuasthofT, U., see Lippert, T. H. Reed, M.A. G., see Tislow,R. Reite,O.B., see Eliassen,K.A. 136, 138, 146 409,436,532,559 137,144 Quinlan,J.E., see Hansch,e. Rees,K.R., see Bangham,A.D. Rekker,R.F. 239,248,362,367 262,290 228,246 Rekker,R.F., Nauta,W.Th. Reeves,J.T., see Tucker,A. 228,229,248 Radecki, T., see Konturek,S.J. 5,15,21,38,469,502 Rekker,R.F., Nauta,W.T., 265,291 Regnier, M. T., see Jarrousse, M. Buitzma,T., Waringa,C.G. Rademacher, E., see Hirsch,E. J. 183,211,234,236,247 216,234,248,388,397,398, 463,492 Rehauit, M. e., see Schwartz,J. 403,404,434 Radwan,A.G., West,G.B. 110, C. 133,148 Rekker,R.F., Nys,G.G. 234, 116,127 Rehault,S., see Schwartz,J.-e. 240,248 Ragins,H., see Dombro,R. 119,129 Rekker,R. F., Timmerman, H., 133, 144 Rehfeld,J.F., see Hakanson,R. Harms,A. F., Nauta, W. Th. Rajsner,M., see Protiva,M. 444,491 183,212,234,23~248 201,212 Rehfeld,J.F., see Konturek,S.J. 387, 388, 390, 402, 413-416, Ralph,E. K., Grunwald,E. 260, 265,291 434 292 Reich,e.F., see Altura,B.M. Rekker,R.F., see DeRoos,A.M. Ramanamanjary, W. 2-4,37, 27,28,31 522,555 470,499 Reichard,S.M., see Galvin,M. Rekker,R.F., see Harms,A.F. Ramunni,G., see Gattegno,D. J., Jr. 112,124 215-217, 219-222, 224, 227, 279,289 Reicher,1., see Schwartz,E. 229,236,242,244,245,247, Ranadive,N.S., Cochrane,e.G. 180,213 387,430 59,60,73,78,91 Reichgott, M. J., Engleman, K. Rekker,R.F., see Nauta,W.Th. Rand,M.J., see Burn,J.H. 400, 584,601 227, 232, 248, 256, 292, 388, 426 Reichgott, M. J., Melmon, K. L. 398,402,404,419,433 Rand,M.J., see McCulloch,M. 583,601 Rekker,R.F., see Nyss,O.O. W. 462,497 Reichle,C., see Friebel,H. 466, 234,240,248 Randall, L. 0., see Lehmann,G. 488 Rekker,R.F., see Roos,A.M.de 203,211,388,413,431 Reid, e. S. W., see Fastier,F. N. 227,229,248,249 Rang,H.P. 300,326,329,331 328,330 Rekker,R.F., see Waringa,C.G. Rang,H.P., see Paton,W.D.M. Reid,J.D., Shepherd,D.M. 216,225,233,237,238,249 300,326,331 110, 115, 127 Remington,1. W., Hamilton, W. Rangel.D.M., Dinbar,A., Reid, W.B., Wright,J.B., KollofT, F., Boyd,G.H., Jr., Hamil• Stevens,G.H., Byfield,J.E., H.G., Hunter,J.H. 197, ton,W.F., Jr., Caddell,H.M. Fonkalsryd,E. W. 575,601 212 578,601 Ranner,N.V.,Ozerov,R.P., Reilly,J.C., see P'An,S. Y. 185, Remmer,H. 549,558 Datt, l. D., Kshnyakina,A.N. 212, 388, 433 Renaud,J.F., see Josephson,l. 266,274,277,292 Reilly, M. A., Schayer, R. W. 401,431 Rapp,H.J. 472,499 113-115, 117-119, 127, 128, Rencis,V., see Maxwell,G.M. Rappaport,B.Z., see Becker,E. 132-134,147,163,172 469,497 L. 421,425 Reilly, M.A., see Schayer,R.W. Renker,H., see Wegmann,A. Rasmussen,A.e., see Parsons, 110,112,114,117-119, 471,503 M.E. 257,292 121,128,132,134.148 Renkin,E.M., Carter,R.D., Ratouis, R., see Boissier,J. R. Reimann,H.-J., see Lorenz, W. Joyner, W. L. 26,37,423, 204,208 143, 147 434 Raventos,J., see Clark,A.J. Reinhard,J.F., Scudi,J.V. 449, Renkin,E.M., see Carter,R.D. 391,427 499 26,33 Read,G. W., Ortner,M.J., Hino, Reinhard,J.F., see Scudi,J.V. Rennick,B., Chess, D., Hays,H. R., Lenney,J. F. 59,73 381,409,412,435 W., Mathieson, D., Mayer,R. Reashbeck,P.G., Young,J.M. 450,451,454,455,462,471, L., Yonkman,F.F. 453,500 413,434 501 Rennick,B., see Yonkman,F.F. Recarte, P., see Grana,A. 467, Reinhardt,D., Wagner,1. 27, 409, 437, 453, 469, 504, 591, 489 37 602 Author Index 641

Resh-Bollhagen,S., see Ber• Rieveschl,G.Jr., see Fleming,R. Rocha e Silva,M., Leme,J.G. nauer, W. 457-459, 482 W. 519,556 443,500 Resch-Bollhagen,S., see Hahn, Rieveschl,G.R. 182, 212 Rocha e Silva, M., Rothschild,A. F. 461,462,490 Rieveschl,G.R., Huber,W.F. M. 435,473,500 Reubi,F. 471,500 182,212,389,409,434 Rocha e Silva, M., see Antonio, Reuse,J., see La Barre,J. 399, Riggilo,D.A., see Brown,J.H. A. 460,481 431,442,455,494 444,483 Rocha e Silva, M., see Bareicha, Reuse,J.J. 180,212,218,248, Riley,J. F., see Cass, R. 474, I. 301,330,456,481 387,388,390,398,409,414, 484 Rocha e Silva, M., see Beraldo, 417, 434, 442, 444, 450, 458, Risberg,A. M., Risberg,J., W.T. 298-300, 330 459,469,470,471,500,591, Ingvar,D. H. 569,572 Rocha e Silva, M., Jr., see Erring• 601 Risberg,J., see Risberg,A. M. ton, M. L. 583,598 Rezende, L., Jr., Diniz, C. R., 569,572 Rocha e Silva, M., see Garcia Mares-Guia, M. 402, 434 Risley, see Van Arman, e. G. Leme,J. 303,331 Rezende,L., Jr., see Mares• 506 Rocha e Silva, M., see Reis, M. L. Guia, M. 301,331 Rispat,G., see Duchene-Marul• 423,434 Rhodes, C. J., see Millican, C. R. laz, P. 409,428 Rocha e Silva, M., see Roth• 590, 592, 600 Ritchie, R. K., Spedding, H., schild,A. M. 93, 108 Ribet,A.,seePascal,J.P. 17,37 Steele, D. 268,292 Rocha e Silva, M., see Vugman, I. Rice,S.A., see Devereux,D.F. Ritzen, M., see Carisson,C. 88, 151,173 586, 587, 597 90 Rocklin,R.E. 440,500 Richards,A.N., see Dale,H.H. Roback,G.S., Krasno,L.R., Rode,C. P., see Kugler,}. 565, 576, 584, 597 Ivy,A.C. 564,572 571 Richards,G.V., see Winter,C.A. Robb,G. P., see Weiss,S. 2, 6, Rodrigues de Miranda,J.F., see 465,503 7, 8, 12, 19,39 Lehmann,P.A. 352,366 Richards,l.M., see Farmer,J.B. Robbins,S.E., see Lish, P. M. Rodrigues de Miranda,J.F., see 472,487 462,496 Lien,E.J. 352, 367 Richards, R. K., see Kimura, E. Robertis,E.de, see Kataoka, K. Rodriguez,A. M., see Close,J.A. T. 443,448,493 120, 125 530,531,555 Richards,R.K., see Roth,L.W. Roberts, E., see Balgooy,J.N.A., Rodriguez,C.F., Johnson,D.E. 381,387,388,409,435,450, van 132, 133,143 521, 539, 558 500 Roberts II,L.J., see Ellis,E.F. Roe,A. M., see Durant,G.J. Richards, W. G., see Ganellin, C. 460,486 286,288 R. 279,289 Robertson, c., Grossman, M.1. Rohlich, P .. Anderson, P., Richardson, C. T., Bailey, B. A., 252,253,292,293 Uvnlis,B. 59,73,79,91 Walsh,J.H., Fordtran,J.S. Robertson, e., see Grossman, M. Romer, D., Cerietti,A. 199,212 265,292 I. 42,55,252,253,289 Romer, D., Weidmann,H. 450, Richardson,C. T., Fordtran,J.S. Robins,A.H. 340 500 265,292 Robinson, D. 520, 558 Roemhild, F., see Wiggers, H. C. Richardson,J. E., see Mitchell, R. Robinson, D., Williams, R. T. 578,602 G. 140, 142, 147 520,558 Rossler, R., see Baer, R. 17, 32 Richardson,J.E., see Thom,H. Roblin,R.O., Jr. 381,434 Rossler,R., see Konzett,H. 140, 142, 149 Rocha e Silva,M. 1,2, 13, 15, 411,431 Richardson, P. D.l., Withring• 37,122,128,256,293 RoggenholTer,R.J. M., see ton,P.G. 469,500 296--301, 303-305, 309-314, Tislow,R. 409,436,532, Richmond,M.T., see Van der 316,320,323-326,329,331, 559 Brook,M.J. 197, 214, 388, 332, 381, 386, 390, 394, 400, Roitt, I. M., see Taylor, W. A. 437,450,455,502 412, 413, 420, 422, 423,434, 466,502 Richter,A. W., see Assem,E.S. 435, 576, 583, 585, 588,601 Romer,D., see Weidmann,H. 64,69 Rocha e Silva. M .. Beraldo, W. T. 523,559 Richter,D. 515,558 296-301,312,332 Romero,L.H., see Motsay,G.J. Rickels, K., Hesbacher, P. T. Rocha e Silva, M., Carvalho, I. F. 580,600 565,572 413,435 Rometsch,R. 195,212 Rickels, K., see Mock, J. E. 566, Rocha e Silva, M., Fernandes, F. Roncevich,A. 184, 212 572 302, 314-316, 321, 325, 332, Ronnberg,A. L., see Schwartz, Ridgway,P., see Douglas,J.S. 396,435 J.-c. 112, 118,129 398,410,428,462,486 Rocha e Silva, M., Fernandes, F., Rooney, P.J., see Grennan,D. M. Ridley,P.T., Groves,W.G., Antonio,A. 317-319, 332, 506,511 Schlosser,J.H., Massenberg, 435 Roos,A.M.de 229,248 J.S. 265,292 Rocha e Silva, M., Garcia-Leme, Roos,A. M. de, Rekker,R. F., Rieder,J., see Eschenhof, E. J. 303,332,386,422,423, Nauta, W. Th. 227, 229, 545,556 435,507,511 248,249 Riesterer,L., Jacques,R., Krupp, Rocha e Silva,M., Grafia,R. Root, W. S., see Deyrup, I.J. 7, P. 509,511 586,588,601 8,33 642 Author Index

Roozemond,R.e., Vegt,G.T.B., Rosenthal,S.R., see Lambert,E. Ruess,K.P., see Walter,W. Hespe, W., Nauta, W. Th. H. 405,431 269,293 548,558 Rosenthale, M. E., Dervinis,A., Ruffin,e.L., see Gordon,L.E. Rosa,L., see Armitage,P. 465, Kassarich,J. 444,500 566,571 481 Roser,J., see Morrison,D.C. Rush,J.E., see Blackwood,l.E. Rosa,L., see Herxheimer,H. 59,72 268,287 398,430,466,492 Rosiere,C.E., see Grossman,M. Russell,D., Snyder,S.H. 111, Rosa,L.M., see Hawkins,D.F. I. 252,253,289 128 455,491 Ross,C.A., see Stone,e.A. 199, Russell,D., see Ensor,e.R. Rose,B. 585,586,588,601 213,443,502,507,512,543, 232,246 Rose,B., Browne,J.S.L. 588, 559 Russo,R. M., Gururaj, V.l., 601 Ross,L.L., see Gershon,M. D. Allen,J.E. 569, 572 Rose,B., Weil,P. 585,586,588, 474,475,489 Rutledge,R.A., see Barrett, W.E. 601 Rossi,G. V., see Smith,R.G. 446,481 Rose,B., see Kovacs,B.A. 370, 562,572 Ryan,M.J., Brody,M.l. 23,38 374,377,378,379,380,455, Rossini,F.D. 329,332 Ryan,M.J., see Boerth,R.e. 493 Roszkowski,A. P., Govier, W. M. 422,426 Rose,B., see Pelietier,G. 374, 184,212,234,249 Ryzewski,J., see Delaunois,A.L. 380 Roszkowski,A. P., see Pe1czar• 5, 7, 8, 15,33 Rose,e., see Schwartz,J.-e. ska, A. B. 468, 499 119,129,170,173 Roth,F., see Yonkman,F.F. Rose,E.K., see Lunsford,e.D. 417,437 Saari, W. S., see Engelhardt, E. L. 449,454,496 Roth,F.E. 198,212 199,209,543,555 Rose,H., see Walter, W. 269, Roth,F.E., Govier,W.M. 194, Saavedra,l.M. 153,173 293 212,234,249,388,404,435, Saavedra,J. M., Axelrod,l. Rose,J. M., Feinberg,A.R., 500 153,173 Friedlaender,S., Feinberg,S. Roth,F.E., see Tozzi,S. 443, Saavedra,J.M., Brownstein,M., M. 441, 450, 451, 455, 500 450,474,502 Axelrod,l. 153, 173 Roseghini, M., see Erspamer, V. Roth,J.L.A., see Ahmadi,A. Saavedra,J.M., Palkovits,M., 133,145 575,594 Brownstein,M.J., Axelrod,J. Roselund-Hansen,O. 215, 249 Roth,L. W., Richards,R.K., 153,173 Rosen,L.A., see Hollis,T.M. Everett, G. M., Shepperd, I. Saavedra,J.M., see Brownstein, 112,125 M. 381,409,435,450,500 M. 568,570 Rosenberg,F.J., see Mielens,Z. Roth, L. W., Richards, R. K., Saavedra,J.M., see Palkovits,M. E. 466,473,474,497 Shepperd,I.M. 387,388, 172 Rosenberg, P., Bartels,E. 417, 409,435,450,500 Saba, T. M. 575, 579, 586, 601 435 Rothlauf,M.V., see Fink,M.A. Saba, T. M., Scovill, W. A. 579, Rosengren,E. 110, 113, 119, 475,487 586,601 128, 135, 136, 138,147,148 Rothschild,A.M., Vugman,I., Sabbah,A. 200,212 Rosengren,E., Svensson,S.E. Rocha e Silva, M. 93, 108 Sacchi,A., see Melli,G. 456, 44,56 Rothschild,A. M., see Rocha e 497 Rosengren, E., see Dencker, H. Silva,M. 435,473,500 Sachs,G., Spenney,J.G., Shoe• 112, 123, 139, 144 Rourke,P., see Kim,K.S. 132, maker,R.L., Sung,e.p., Rosengren,E., see Dzodzo., Y. 146 Jenkins, B. D., Wiebelhaus, e.G. 111,123 Roux,J., see Halpern,B.N. V.D. 46,56 Rosengren, E., see Graham, P. 444,491 Sachs, G., see Hirschowitz, B. I. 110,124 Roux,J.-L., see Halpern,B.N. 54,55 Rosengren,E., see Grahn,B. 444,491 Sacheyfio,A.e. 452,500 111, 113, 119,124 Rovenstine,A., see Baez,S. Sacheyfio,A.e., see Hicks,R. Rosengren,E., see Henningsson, 583,596 463,464,492 S.S.G. 112, 119, 125, 135, Rowley,D.A. 26,37 Saedd,S.A., see Butt,A.A. 510, 138,145 Rowley,D.A., Benditt,E.P. 511 Rosengren,E., see Kahlson,G. 386,435 Saeki,K., Wake,K., Yamasaki, 1,35,43-45,56, 110--112, Roy,A.e., Warren,B.Y. 64,73 H. 440,500 117, 119, 122,125, 135, 137, Rozenberg,M.e., see Murer,E. Saenger, W., Suck, D. 279, 293 146 H. 68,72 Saijo,S. 193,213,532,558 Rosenthal,S.M., see Lamson,P. Rubin,B., see Feinstone, W. H. Saint-Hilaire,J., see Bordeleau, D. 3,4,17,35 180,209,381,409,429,447, J. M. 565,566,570 Rosenthal, S. R., Brown, M. L. 487 Sakai,K., see Ishida,Y. 375, 442,445,450,455,456,500 Ruckart,R., see DaVanzo,J.P. 376, 377,379 Rosenthal,S.R., Brown,N. 562,570 Salama,S., see Anrep,G. V. 405,435 Riihl,A. 14,38 422,425 Rosenthal,S.R., Minard,D. Ruelius, H. W., see Sisenwine,S. Salomon,H., see Miiller,E.A. 405, 417,435 F. 545,559 14, 15,36 Author Index 643

Saltz,N.J., see Hass,H. 575, Schauer.A., see Lorenz, W. Schild, H. 0., see Mongar,1. L. 599 139, 147 65,72,93,96,108,441,497 Sams, W. M., see Winklemann, Schaumann, E., see Walter, W. Schild,H.O., see Wan,B.Y.e. R.K. 27,39 269,293 265,293 Samuelsson, G., see Bergqvist, U. Schayer, R. W. 1, 23, 24,38, Schild, W .. see Hahn, F. 448, 78,82,85,90 109-111,114,115,119,121, 490 Sanchez. V .. see Alonso-de-Flo• 122, 128, 131, 134-137, 148, Schilf, E., see Feldberg, W. 471, rida,F. 456,480 576, 584,601 487 Sandberg, N., Steinhardt, e. Schayer, R. W., Karjala,S.A. Schiller,S., Dorfman,A. 83,85, 110, 128 282.293 91 Schayer,R. W., Kennedy) .. Sanders, D.J., see Thompson, M. Schindler, O. 181,213 Smiley,R.L. 131, 136, 148 H. 265,293 Schindler, W., Hafliger.F. 201, Schayer, R. W., Kobayashi, Y.. 213 Sandusky, e. B., Johnson, A. R .. Smiley, R. L. 152, 173 Schingale,F., see Thermann, M. Moran,N.C. 60,73 Schayer,R. W., Reilly. M.A. 2,3. 5, 7, 8, 15, 17,21,38 Sanford,J., see Aitken, M. M. 110, 112, 114, 117-119, Schlag, G. 579,601 476,480 121.128,132,134,148 Schlichtegroll,A. v. 180.183, Sanford,J., see Alexander, F. Schayer,R. W .. Sestokas,E. 197.198,213,218,226,249, 476,480 118,129 387. 388. 398. 406, 409, 411, Sannella, T., see Brown, E. A. Schayer.R. W., see Ham,E.A. 414-416,435,465,501 185,208 131.145 Schloemer, H. F., see Sherrod, T. Sano,J., see Nakajima, T. 139, Schayer. R. W., see Lindell, S.-E. R. 409.416.436,462,501 147 118.126 Schlosser,J. H., see Ridley, P. T. Sanyal,R.K., West,G.B. 83, Schayer.R.W., see Moore,T.e. 265,292 91,471,472,474.500,501 110, 116, 127 Schmal,A., see Lorenz, W. 143, Sanyal, R. K., see Dhar, H. L. Schayer,R.W., see Reilly, M.A. 147 474,486 113-115,117-119,127,128, Schmal, A., see Thermann,M. Sanyal,R.K., see Sen,P. 143. 132-134,147, 163,172 2,3,5,7,8, 15, 17,21,38 148 Scheele. W .. see Koslowski, L. Schmid,H.J., Hunger, A., Hoff• Sara vis, e., see Clowes, G. H. A .. 586,587,599 mann, K. 202, 213 Jr. 575,597 Scheib Ii. K., see Jaques, R. 217 Schmiterlow, e. G. 538, 559 Saravis,e.A., see Farrington,G. Scheline, R. R., Smith, R. L., Schmiterlow, e. G., Wessman,e. H. 575,598 Williams, R. T. 554, 559 G. 444,501 Sardesai, U. M., see Thal,A. P. Schelske, E. M., see Credner, K. Schmiterlow, e. G., see Hansson, 583,602 218.246,387,427,464,486 E. 197,210,538,539,556 Sasaki,D., see Kikkawa,M. Schenker, E., Herbst, H. 176, Schmitt,R.G., see Hirt,R.e. 520,557 197,198,213 266,290 Sato, T. L., see Levine, R. J. 116, Scheraga, H. A., see Gibson, K. Schmitz-Bocklenberg,G., see 126 D. 289 Hahn,F. 471,490 Saul,W.F., see Maling,H.M. Schiede, M., see Alberty,J. 399, Schmutz,J., see Ackermann,H. 27.36.508.510,511 425,455,480 446,480 Sawada, A., see Ishida, Y. 375, Schild, H. O. 73, 178, 180, 183. Schmutz,J., see Hunziker,F. 376,377,379 213,215,218,249,251,293 202,210 Sawyer,e.H. 568,572 332, 372, 380 Schmutzler, W. 132, 134,148 Schachter, M. 470,501 386,387,390,393,396,398, Schmutzler, W., Goldschmidt, Schachter, M., see Collier, H. O. 413.435,454,501 0., Bethge, K. P., Knop,J. J. 411,427 Schild. H. 0., Hawkins, D. F., 444,501 Schachter,R.J., see Ercoli,N. Mongar,J.L., Herxheimer, Schmutzler. W., see Bernauer, W. 381,387,409.428,447,487 H. 398,435,454,501 134, 144 Schaefer, F. e., see McAdam, J. Schild, H. 0., see Arunslakshana, Schmutzler, W., see Giertz. H. R. 274,292 O. 218,246, 251, 252, 287, 441, 445, 448, 452-454, Schar, B., see Jaques, R. 448, 302,330,392,395,414,425 466,468,472,489 474,493 Schild.H.O., see Ash,A.S. 175, Schmutzler, W., see Hahn, F. Schaffrin,R., see Veidis, M. V. 207,252,253,287 444,445,453,454,490,491 182,214 Schild,H.O., see Assem,E.S. Schneider, H., see Bohme, H. Schanz,H.-M., see Bernauer, W. 61. 67,69, 106,106, 113,123 286,288 461,464.482 Schild, H. 0., see Daly, I. B. de Schneider. M. W., see Hitchcock, Schaper, W. K.A., Jageneau,A. 386,427 M. 58,71 H. M., Xhonneux, R., van Schild, H. 0., see Ghosh, M. N. Schneider, W.e. 266, 274, 293 Nueten,J., Janssen, P.A.J. 254,289 Schoefl,G.I., see Majno,G. 26, 531,558 Schild, H. 0., see Graham, P. 36 Schauer,A. 587,601 110, 124 Schottler, W. H. A. 469, 470, Schauer, A., see Aures, D. 112, Schild,H.O., see Hawkins,D.F. 501 123 218,247,251,290,442,491 Schofield, B. 44, 56 644 Author Index

Scholtz,N., see Poch,G. 401, Schwartz,J.-c., see Pollard,H. Seseke,G., see Hahn,F. 444, 434 110, 120, 127 491 Scholz,C.R., see Djerassi,C. Schwartz,N.L., see Brown,J.H. Sestokas,E., see Schayer,R.W. 181,209 444,483 118,129 Scholz, C. R., see Huttrer,c. P. Schwartz,S., see Galindo,A Seth,S.D.S., Mukhopadhyay, 180,210,409,430 568,570 A, Bagchi,N., Prabhakar, Scholz,C.R., see Mayer,R.L. Schwenk, E., see Sperber, N. M.C., Arora,R.B. 370,380 409,432,449,497 183, 184, 193, 194,213,532, Seth,S.K., see Witiak,D.T. Scholz,N., see Poch,G. 9,12, 559 204,214 37,458,499 Scott,J.B., see Haddy,F.J. 23, Sethi, O. P., see Gerald, M. C. Schreiber, W., see Vinegar,R. 26,34,581,598 204,209 507,512 Scott,R.S., Wallace,K.H., Sethi,O.P., see Witiak,D.T. Schretzenmayr,A. 17,38 Badley,D.N., Watson,B.H. 204,214 Schretzenmayr,A., see Ganter 566,572 Severs, W. B., see Beaven, M. A. G. 18,19,34 Scovill, W. A., see Saba, T. M. 116,123 Schumann,H.J., see Reinhardt, 579, 586, 601 Sewing,K.F. 44,45,56 D. 401, 434, 440, 457, 458, Scudi, J. V., Reinhard, J. F., Sewing,K.F., see Albinus,M. 499,500 Dreyer,N.B. 381,409,412, 2, 3, 6, 8, 11, 21,30,264,287, Schulemann, W., Friebel, H. 435 463,480 181,213,435 450, 451, 454, 455, 462, 471, Shaff,R.E., Beaven,M.A. 169, Schuber, W.A., Klebe,H. 198, 501 173 213 Scudi, J. V., see Reinhard, J. F. Shaff,R.E., see Kaplan,A.P. Schulman,P.H., see McGavack, 449,499 164,172 T.H. 183,211 Seabury,J.H., see Levy,L. II Shafi'ee,A., Hite,G. 184, 195, Schultz,L.S., see Motsay,G.J. 398,432 213,236,249 580,600 Sedivy,Z., see Jilek,J.O. 201, Shapiro,R.N. 564,572 Schultz, W. H. 399,435 211 Share,L. 576,583,602 Schultz-Dale 455 See gal, B. c., see Wilcox, H. B. Share,N.N., see StotIand,L.M. Schulze, W., see Wollenberg,A. 9,13,14,21,39,409,437,445, 472,502 401,437 450,503 Shaw,G.G. 568,572 Schumann,H.J., see Reinhardt, Seeman,P. 419,420,436 Shay,H. 378 D. 12, 37 Seevers, M. H., see Wyngaarden, Shay,H., Komarov,S.A., Berk, Schumer, W. 575,576,587,601 J.B.534,560,561,573 J. E. 378,380 Schumer, W., Nyhus, L. M. Seidel, W., see Lorenz, W. 143, Shea,S.M., see Majno,G. 24, 577,581,601 147 26,36 Schuppli,R. 470,501 Seidlova, V., see Jilek,J.O. 201, Sheard,P., see Farmer,J.B. Schutzer,S., see McGavack,T. 211 472,487 H. 513, 516, 518, 523, 524, Seidlova, V., see Protiva, M. Shearman,A.H., see McGavack, 558 201,212 T.H. 183,211 Schwab,R.S., see England,A.C. Selkurt,E. E. 581,601 Shearman,D.J.C., see Carter,D. 561,570 Selle, W.A. 450,455,501 C. 265,288 Schwark,W.S. 509,511 Selph,J. L., see Vinegar,R. 507, Shelton, R. S., see Tilford, C. H. Schwartz, E., Reicher,J. 180, 512 184,213 Shenkin,H.A. 19,38 213 Selye,H. 23,38 Schwartz, E., Wolf,J. 421, 435 Shepherd,D.M., Woodcock,B. Schwartz,J.-c. 115, 119, 120, Sen, P., Sanyal,R.K. 143, 148 G. 111, 114, 129 122, 129, 133, 148 Sen, P., see Chakravarty, N. 63, Shepherd,D.M., see Mole,K.H. Schwartz,J.-c., Lampart,C., 69 116,117,127,467,497 Rose,C. 119, 129, 170, 173 Senay,E.C., see Levine,R.J. Shepherd, D. M., see Reid,J. D. Schwartz,J.-c., Lampart,c., 112,126 110, 115, 127 Rose,C., Rehault,S., Bi• Senger,M., Greeff,K. 458,459, Shepherd,J.T., Vanhoutte,P.M. schoff,S., Pollard,H. 119, 501 1,27,29,38 129 Senges,J., Katus,H., Kubler,W. Shepherd,J. T., see Duff,F. 19, Schwartz,J.c., Pollard, H., Bi• 459,501 33 schoff,S., Rehault,M.C., Serafini, U. 386,409,436 Shepperd, I. M., see Roth, L. W. Verdiere-Sahuque,M. 133, Serafini, U., Mene,G. 421,436 381, 387, 388, 409, 435, 450, 148 Serate, T.S., see Glenn, T. M. 500 Schwartz,J.-c., Ronnberg,AL., 598 Sheraga, H. A., see Steinberg, I. Z. Cohen,Y., Valette,G. 112, Serjeant,E. P., see Albert,A. 310,311,315,332 118, 129 176,207 Sherlock,M., see Sperber,N. Schwartz,J.-c., see Baudry,M. Seseke,G., see Bernauer, W. 183,184,193,194,213 110, 119, 123 134,144 Sherrod,T.R., Loew,E.R., Schwartz,J .-C., see Garbarg, M. Seseke,G., see Giertz,H. 466, Schloemer,H.F. 409,416, 120,124,568,571 472,489 436,462,501 Author Index 645

Shevchenko,A. I. 477, 501 Sjaastad,O., Sjaastad, 0. V. Smith,R.G., Rossi,G.V., Shibata,K., see Kurihara,N. 140, 143,148 Orzechowski,R.F. 562, 455,493 Sjaastad, 0., see Dohlen,H. 572 Shiina, Y., see Okamura, T. 141,144 Smith,R.L., Williams,R.T. 399,433,456,498 Sjaastad,O., see Sjaastad,O.V. 559 Shipman, W. F., see McLaurin, 140, 143, 149 Smith, R. L., see Scheline, R. R. J. W. 411,433 Sjaastad,O. V. 133, 136, 138, 554,559 Shoemaker,R.L., see Sachs,G. 148 Smith,T.W., see Bakhle,Y.S. 46,56 Sjaastad,O.V., Kay,R.N.B. 443,481 Shoemaker, W.e. 578,579, 138,148 581,602 Smith, W., Humphrey,J.H. Sjaastad,O.V., Sjaastad,0. 467,501 Shore, P.A., Burkhalter, A., 140, 143, 149 Smith,W.G., see Eilbeck,J.F. Cohn,V.H. 151,155,173 Sjaastad, V., see Dohlen, H. 0. 464,486 Shorley,P.G., see Collier,H.O. 141, 144 J. 411,427 Sjaastad,O.V., see Sjaastad,0. Smith, W.G., see Firth,A. 466, Shorr,E., Zweifach,B. W., 140, 143, 148 488 Furchgott, R. F., Baez, S. Sjoberg, N.-O., see Bjorklund,A. Smith, W. G., see Goadby, P. 575,602 121,123 464,489 Shotlander, V., see Bangham,A. Sjoberg. N.-O., see Hakanson,R. Smy,J. R., see Harris, D. 264, D. 228,246 124 290 Shrader,S. R., see Sisenwine, S. F. Sjoqvist,F., Lasagna,L. 561, Smy,1.R., see Reed,J.D. 21, 545,559 564, 566, 572 37, 49, 50, 53,56 ShrotT,P.F., see Brown,e.R. Sneddon,J.M. 68,73 561,563,566,570 Sjoerdsma, A., Waalkes,T.P., Weissbach, H. 168, 173 Snedecor,G.W., Cochran, Shubin,H.,seeWeil,M.H. 577, 579,602 Sjoerdsma, A., see Levine,R.l. W.G. 415, 416, 419, 436 Snell, K.e., see Hosoda,S. Sica, V., see Cuatrecasas, P. G. 116,126 295,330 Sjoerdsma,A., see Loeffier, L.J. 110, 125 Snyder,F.H., Klahm,G.R., Siegmund,O.H., see Lands,A. 61.72 Werner,H.W. 515,559 M. 180,211,387,409,431 Sjoerdsma,A., see Oates,J.A. Snyder,S.A., see Horn,A.S. Siess, M. 455, 501 140, 141, 147 567,571 Sievers, B., see Bernauer, W. Skidmore, L. F., Whitehouse, Snyder,S. H., Axelrod,1. 134, 144 M. W. 116,129 132-134,149 Sigal,B., Herblot,M. 200,213 Sloop,R. D., see Johnson, L. P. Snyder,S.H., Axelrod,1., Siggins,G.R., HotTer,B.l., 543,544,557 Bauer, H. 114, 129 Bloom, F. E. 568, 572 Slorach,S.A. 88.91 Snyder,S. H., Baldessarini,R., Simkins,M.A., see Burland, W. Slorach,S.A., Uvnas,l:l. 59,73, Axelrod,1. 151, 153, 156, L. 265,288 106, 108 160,163,164,173 Simkins,M.A., see Wood,e.J. Slorach, S. A., see Anderson, P. 552,560 59,69,79,90 Snyder,S.H., Baldessarini, R.J., Axelrod,1. 109, 120, Simmons, E., see Thomas, H. V. Slorach,S.A., see Nosal,R. 129 143,149 88,91 Simonis,A.M., Ariens,E.J. Snyder,S.H., Brown,B., Kuhar, Smallman,E.T., see Markley,K. M.J. 121,129 352, :165,367 163, 164, 167, 172, 440, 496, Snyder,S. H., Epps, L. 118, 129 Simonis,A. M., see Ariens, 585 587, 590, 592, 593, 600 Snyder,S.H., Glowinski,J., E.J. 252,254,280,283,285, Smiley,R.L., see Schayer,R.W. Axelrod,J. 133,149 287, 296, 301, 326, 329, 343, 131, 136, 148, 152,173 Snyder,S. H., Taylor, K. M. 345, 352, 365, 366 Smith, C. Mce., see Chinn, H.1. 153, 169, 170, 173, 444, 502 Singer,S.J. 295,332 411,427 Snyder,S. H., see Dismukes, K. Sinha, Y. K., see Mishra, B. N. Smith,E., see Guth,P.H. 421, 169,172,568,570 444,497 430 Snyder,S.H., see Kuhar,M.l Siraganian, P. A., Siraganian, Smith,G. M., Coletta,e.G., 132, 146 R.P. 58,73 McBride,S., McPeek,B. Snyder,S. H., see Russell, D. Siraganian,R. P., see Osler,A.G. 564, 565, 572 111,128 68, 72 Smith,1., see Yonkman,F.F. Snyder,S. H., see Taylor, K. M. Siraganian,R. P., see Siraganian, 417,437 109, 120, 129, 132, 134, 149, P.A. 58,73 Smith,M.J., Denner,J.L. 561, 161, 162, 164, 165, 169, 170, Sisenwine,S.F., Tio,e.O., 572 17 3, 568, 573 Shrader,S. R., Ruelius, Smith,N.T., Corbascio,A.N. Sobhon, P., see Limlomwongse, H. W. 545,559 577-579,602 L. 48,56 Sixt,R., Svensson,S. E., Wiberg• Smith, P. K., see Chinn,H.I. Soh,K.S., see Ison,R.R. 180, Wetterqvist,A. K., Wetter• 183, 185,208,411,427,567, 188, 190, 193, 194,203,210, qvist,H. 141,148 570 218, 226, 236-238, 240, 247, Sjaastad,O. 140, 141, 143, 148 Smith, R. E. 509.512 312,331 646 Author Index

Soh,K.S., see Ison,R.R. 387, Spink,W.W., see Reddin,J.L. Stelt,c. van der, Heus, W.J., 388,398,430 585, 587, 601 Nauta,W.Th. 234,236, Sohn,R., see Mathe,A.A. 443, Spinner, E., see Burawoy,A. 249 496 228,246 Stelt,c. van der, et al. 236,249 Solmssen, U. V., see Ercoli,N. Spoerlein,M.T., Makovsky,E., Stenson,W., see Sullivan,T.J. 387,428 Margolin,S., Tislow,R. 61,62,64,73 Solmssen, U. V., see Leonard, 450,501 Stephenson,E.H., Allmark, F. 409,431 Sprinkle,M.R., see Hall,N.F. M.G. 561,567,572 Somlyo,A. P., Somlyo,A. V. I, 256,290 Stephenson,R. P. 255, 293, 27.29,38,575,602 Stadi,P., see Hakanson,R. 299,324,332,397,436 444,491 Somlyo, A. V., see Somlyo, A. P. Stern,F.H. 564,572 1,27,29,38,575,602 Stahl, W. M. 581,602 Stern,P. 510,512 Sommerville,L.A. 153,173 Stanworth,D.R. 93, 108 Stern,P., Milin,R. 466, Somorjai,K., see Hahn,F. Stanworth,D.R., Humphrey, 501 445, 448, 451, 457, 460, 461, J.H., Bennich,H., Stevens,G.H., see Rangel,D.M. 463,467,490,491 Johansson,S.G. P. 60,73 575,601 Sondergaard,J., Glick,D. 112, Starr,M.S., West,G.B. 472, Stewart, H. L., see Hosoda,S. 129 501 110,125 S0rensen,H.J., see Chakravarty, Starr, M.S .. see Dawson, W. Stiefel, C., see Halpern,B. N. N. 58, 69, 95, 98-100, 107 472,486 185,209,448,491 Sosman,J., see Busse, W. W. Starzecki,B., see Halmagyi, Stille, G., see Caviezel,R. 440,484 D. F.J. 16,21,34 446,484 Soto, C. S., see Ishizaka, T. Starzecki, B., see Reddin,J.L. Stockel,R.F. 274,293 60,71 585, 587,601 Stockmann,R. 453,501 Soudijn, W., van Wijngaarden, Staszewska-Barczak,J., Vane, Stoll, A., Bourquin,J. P. 182, I. 531,559 J.R. 463,501 213 Souidan,Z., see Anrep,G.V. Staub,A.M. 2-5,38, 179,213 Stoll,W.G., Frey,Ch., Morel, 422,425 381, 387, 389, 399, 405, 409, Ch.J. 186,213 Sourkes,T., see Huzsti,L. 117, 413, 436, 441, 444, 446, 470, Stoll,W.G., Morel,Ch.J., Frey, 125 501,590,591,602 Ch. 186,213 Southwell, N. 386,436 Staub,A.M., Bovet,D. 381, Stone,C.A., Loew,E.R. 444, Sowinski, F., see Yale,H.L. 409, 436, 445, 446, 455, 501 502 202,214 Staub,A.M., see Bovet,D. Stone,C.A., Wenger,H.C., Sparrow, M. P., see Lulich, K. M. 179, 208, 381, 424, 426, 446, Ludden,C.T., Stavorski, 477,496 483 J.M., Ross,C.A. 199, 213, Spector,S., see Halpern,B. N. Staub,H., Grassmann, W. 443, 502, 507, 512, 543, 559 475,491 14,21,38 Stone,C.A., see Engelhardt, Spector,S., see Howland,R.D. Staufer,S.C., see Hucker,H.B. E.L. 199,209,543,555 23,35 543-545,557 Stone,S. H. 445, 502 Spector, W. G. 423,436 Stavorski,J. M., see Engelhardt, Stoner,H.B., see Green,H.N. Spector, W.G., Willoughby, E.L. 199,209,543,555 576,598 D.A. 508,512 Stavorski,J.M., see Stone,C.A. Stoner,]., Manganiello, V. c., Spedding, H., see Ritchie,R.K. 199,213, 443, 502, 507, 512, Vaughan,M. 64,73 268,292 543,559 Stormorken,H. 453, 502 Spencer,K.E.V., see Black, Storstein,O., Cudkowicz,L., Stechschulte,D.J., Austen,K.F. J. W. 264,285,287 Attwood,H.D. 15, 38 63,73 Spencer, P.S.J., see Harris, StotIand,L.M., Share,N. N. J.M. 378,379 Stechschulte,D.J., Austen,K.F., 472,502 Bloch,K.J. 413,436 Spenney,J.G., see Sachs,G. StotIand,M., Francis,L.E., 46,56 Stechschulte, D. J., see Tauber, Melville, K.1. 370,373,374, Speralakis,N., see Josephson,l. A.1. 64,73 378,380 401,431 Steele,D., see Ritchie,R.K. Stovall,R., Jackson,R. T. 411, Sperber,N., Papa, D., Schwenk, 268,292 436 E. 193,213,532,559 Steffek,A.J., King,C.T.G., Straus,B., Eisenberg,J., Gennis, Sperber,N., Papa, D., Schwenk, Wilk, A. L. 529, 559 J. 564,573 E., Sherlock,M. 183, 184, Stein, H., see Movat,H.Z. Strauss,H.L., see Hirt,R.C. 213 467,498 266,290 Sperber,N., Papa, D., Schwenk, Steinberg,I.Z., Sheraga,H.A. Stresemann,E. 467,502 E., Sherlock,M., Fricano,R. 310,311,315,332 Stresemann, E., see Herxheimer, 193,194,213 Steinberg, M. I., Holland,D.R. H. 465, 466,492 Sperow,J.W., see Yellin,T.O. 401,436,458,501 Strickland,M.J., see Code,C.F. 506,512 Steinhardt, c., see Kahlson, G. 471,485,585,588,597 Spink,W.W., Davis,R.B., 112, 117, 125 Strominger,J.L. 551, 559 Potter,R., Chartrand,S. Steinhardt,C., see Sandberg,N. Strube,R.E., see Hanze,A.R. 585-587,602 110,128 202,210 Author Index 647

Stubbins,J.F., Hudgins,P.M., Svensson,S. E., see Kahlson,G. Takenaka,F. 459,502 Andrako,J., Beebe,A.J. 110,125 Takeuchi, M., see Harada, M. 345,367 Svenson, S. E., see Rosengren, 467,473,475,491 Stubbs,C.S.Jr., see Ellenbogen, E. 44,56 Takkunen,R., see Alberty,]. L. 116,124 Svensson,S. E., see Sixt,R. 141, 467,480 Sturdevant,A.L., see Mainardi, 148 Talbott,M.W., see Barch,G.K. M. 265,291 Swank, M., see Halloran, L. G. 477,481 Sturgess,R.M., see Parratt,J.R. 265,290 Taliani,L., see Boissier,J.R. 584,601 Swearingen, c., see Kales,J.D. 204,208 Subramanian, N., Nandi,B. K., 565,571 Taller,D., see Burns,J.J. 549, Majumder,A.K., Chatterjee, Sweeley.C.c., see Fish,M.S. 551, 552, 555 I.B. 115,129 521.556 Tau,E. M., see Matsumara, Y. Subramanian,N., see Nandi, Sweetman,B.J., see Ellis,E.F. 474,496 B. K. 115, 127 460,486 Tan, T. L., see Kales,J. D. 565, Suchowsky,G.K., see Fregnan, Swenson, E. W., Arborelius, M., 571 G. B. 475,488 DaicolT, G. R., Bartley, T. D.. Tangri, K. K., see Gupta, M. B. Suck,D., see Saenger, W. 279, Lilja,B. 16,21,38 462,490 293 Swenson,E. W., see Arborelius, Tanner, C. E., see Ismail, M. M. Suda,M., see Ishikawa,E. M. 16,21,32 474,493 111, 125 Swineford,O.,Jr., Motley, Tarras-Wahlberg,B. 588,602 Sugiyama,K., Yamasaki,H. V.A., Tull,L.N. 466, 502 Tasaka, K. 442, 502 58,73,79,91 Symchowicz,S., Korduba,C.A., Tasaka,K., Akagi,M. 410,436 Sugiyama, K., see Tasaka, K. Veals,J. 567,573 59, 73 Symchowicz,S., see Korduba, Tasaka,K., Endo,K., Yamasaki, Suhaciu,G., see Cirstea,M. C. A. 567, 571 H. 59,73 441,446,455,469,485 Symchowicz,S., see Peets,E. A Tasaka, K., Sugiyama, K., Sullian,H.R., see McMahon, 533,558 Komoto,S., Yamasaki,H. R.E. 521,558 Szebehely,J., see Fabinyi• 59,73 Sullivan,A.L., GrimIey,P.M., Szebehely, M. 462, 487 Tasaka,K., see Yamasaki,H. 442,504 Metzger,H. 61,73 Szerdahelyi,M., see Karady,S. Tasi,I., see Kuntzman,R. 178, Sullivan, T.J., Greene, W.c., 369,370,379 211 Parker,C. W. 58,61,73 Szidon,J. P., see Pietra,G.G. Tasler,J., see Konturek,S.J. Sullivan,T.J., Parker,K.L., 26,37 265,291 Eisen,S.A., Parker,C. W. Szilagyi, T., see Kesztyiis, L. Tauber,AI., Kaliner,M.A., 62,63,73 455,493 Stechschulte,D.J., Austen, Sullivan,T.J., Parker,K.L., Sziics,E., see Went,S. 400,437 K.F. 64,73 Stenson,W., Parker,C.W. Szuna, A., see Kamm, J. J. Tauber,R., see Lorenz, W. 143, 61,62,64,73 533,557 Sung, C. P., see Sachs, G. 46,56 147 Sung,c.Y., see DaiIey,R.E. Taubert, M., see Esch, F. 369, 515,516,555 379 Tabachnick, 1.1. A., see Tozzi,S. Sunshine,A. 564,573 Taylor,D.C. 281, 282,293, 443,450,474,502 Suntay,R., see Lear,E. 566, 553,559 Taber, R.I., see Barnett, A 562, Taylor,J.C., see E1combe, M. M. 571 567,570 Sury,E., see Huebner,C.F. 266, 268, 277, 289 Taeschler, M., see Weidmann, H. 202,210 Taylor, K. M., Gfeller, E., 523,559 Sutherland, L. H., see Vaughan, Snyder,S.H. 169,173 Taft,R. W. 249 J. R. 180,214 Taylor, K. M., Snyder,S. H. Taggart,M., see 109, 120, 129, 132, 134, 149, Sutter, M. C. 27,38 Kabasakalian, P. 532, 533, 161, 162, 164, 165, 169, 170, Suzuki,T. 461,502 557 Svahn,D., see Kahlson,G. Taichman,N.S., Movat,H.Z. 173,444,502,568,573 43,44,56, 137, 146 467,502 Taylor, K. M., see Kuhar, M. J. Svatek,S., see Jilek,J. 0. 201, Taichman,N.S., see Movat, 132,146 211 H.Z. 467,498 Taylor, K. M., see Snyder,S. H. Svec, P., see Mongar,J.L. 63, Takabatake,E., see Kataoka,S. 153,169, 170,173 65,72 521, 522, 534, 542, 543, 557 Taylor,R.J.,Jr., Leinweber, F.J., Svendstrup, F., Chakravarty, Takagi,K., Fukao,T. 475,502 Braun,G.A. 116,129 N. 101,108 Takagi,K., Uchida,M. 295, Taylor,R.J.,Jr., see Ellenbogen, Svendstrup, F., see Chakravarty, 332 L. 116,124 N. 101. 107 Takahashi, H., see Webster, Taylor,W.A., Roitt,I.M. 466, Svensson,S.E. 44,56 M.E. 163,164,167,173 502 Svensson,S.-E., Wetterqvist, H. Takanaka,A., see Kato,R. 521, Tebecis,A. K., see Phillis,J. W. 110, 114, 129, 138, 141, 149 557 568,572 Svensson,S.E., see Granerus, Takayanagi,1. 388, 389, 398, Tell,P.E., see Cuatrecasas,P.G. G. 142,145 436 295,330 648 Author Index

Terlain,B., see Jolles,G. 541, Thompson, I. D., Dolowy, W. e., Titus, E. 0., Craig, L. e., 557 Cole,H. W. 549, 559, 563, Columbic,C., Mighton, Terrier,J.e., see Wakim,K.G. 573 H.R., Wempen,I.M., Elder• 19,39 Thompson, I. D., see Duff,F. field,R.e. 521,559 Tersteege, H. M., see Bijlsma, 19,33 Tobia,A.J., Adams,M.D., V.G. 183,208 Thompson,J.E., see Cabrera,G. Miya,T.S., Bousquet,W.F. Tersteege,H. M., see Funcke, 417,420,426 23,38 A. B. H. 201, 209, 547, 556 Thompson,J.H., see Aures,D. Tobia,A.J., see Akin,F.J. 133, Teschendorf, H. J., Kretzschmar, 112,123 134, 143 R., Niehoff,E. 468,502 Thompson, M. H., Venables, Tornqvist,A. 141,149 e. W., Miller,I. T., Reed,J. D., Tornqvist,A., see Lindberg,S. Teschendorf,H.1., see Hahn,F. Sanders,D.J., Grund,E.R., 141,146 445, 454, 457, 467, 468, 472, Toki,A., see Ishikawa,E. 111, 490,491 Blair,E.L. 265,293 Thomson,A.E., see Cort,J.H. 125 Teschendorf, H. 1., see Kretzsch• 579,597 Tokuda,S., Weiser,R.S. 475, mar,R. 468,493 Thon, I. L., Vvnas, B. 58,73,75, 502 Testa,B. 249 79,82,86,91 Toldy,L., Vargha,L., Toth,I., Tetreault, L., see Bourdeleau, Thon,I.L., see Vvnas,B. 58, Borsy,J. 198,213 J.M. 565,566,570 59, 74, 75, 92, 93, 108 Tolone,G., Bonasera,L., Teutsch,G., Mahler,D.L., Thornby,1. I., see Cook, T.J. Bruno,R. 474,502 Brown, e. R., Forrest, W. H., 421,427 Tolstoouhov,A. V. 227, 249 James,K.E., Brown,B.B. Thron, e. D. 324, 325, 332 Tolstoouhov,A. V., see Friedman,H.L. 180,209 569,573 Thunberg,R., see Kahlson,G. Toman,J.E.P. 420,436 ThaI, A. P., Sardesai, V. M. 43-45,56, 110, 125, 137, 146 Tomashiro,K., see Korolkovas, 583,602 Thurmayr,R., see Kugler,J. Thal,A. P., see Hermreck,A.S. A. 302,331 565,571 Tomchik,R., see Brown,D.D. 579,599 Tibbling,G., see Hansson,R. ThaI, A. P., see Kobold, E. E. 134, 144, 156, 171 134,145 Tomioka,H., Ishizaka,K. 67, 575,599 Tickner,A. 463,502 ThaI, A. P., see Wilson, R. F. 74 Tilford,e.H., Shelton,R.S., van Tomioka, H., see Ishizaka, K. 578,602 Campen,M.G. 184, 213 ThaI, P., see Hashimoto,E. 60,71 Tilney, L. G., see Marsland, D. 575,598 Tompa,A.S., Barefoot,R. D. 63, 72 Tham,R. 140, 142, 143, 149 Price, E. 269,293 Timmerman, H., see Harms, Tham,R., Holmstedt, B. 131, Tong,G.L., see Lien,E.J. 363, A.F. 215-217,219-222, 149 367 224, 227, 229, 236, 242, 244, Theodore,J. M., see Lange, Toth,I., see Toldy,L. 198,213 245,247, 387,430 W.E. 532,558 Touster,O. 551,559 Theogaraj,J., see Cho, Y. W. 3, Timmerman,H., see Nauta, Townley, E., see Kabasakalian, 5,8,15,33,585,586,596 W. Th. 232,247 P. 532,533,557 Thermann, M., Lorenz, W., Timmerman, H., see Rekker, Tozzi,S. 175,213,217,440,502 Schmal,A., Schingale,F., R. F. 183, 212, 234, 236, Tozzi,S., Roth,F.E., Dormann, P., Hamelmann, 248,387,388,390,402, Tabachnick, I. I. A. 443, H. 2,3,5,7,8, 15, 17,21,38 413-416,434 450,474,502 Thewalt, V., Bugg, e. E. 279, Tio,e.O., see Sisenwine,S.F. Tracy,H.J., see Gregory,R.A. 293 545,559 42,55 Thithapandha,A., see Limlom• Tipker,J., see Verloop,A. 363, Traina, V., Aleksandrowicz, D. wongse, L. 48, 56 367 442,502 Thjodleifsson, B., Wormsley, Tislow,R., LaBelle,A., Treibs, W., Klinkhammer, H. 1. K.G. 265,293 Makovsky,A.J., Reed, 199,213 Thom,H., Richardson,J.E., M.A. G., Cunningham, MD., Trendelenburg, V. 7,10,12,38, Mitchell,R.G. 140, 142, Emele,J.F., Grandage,A., 252,293,400,436 149 Roggenhofer,R.J. M. 409, Trendelenburg, V., Hobbs, R. D. Thom,H., see Mitchell,R.G. 436,532,559 457,502 140, 142, 147 Tislow,R., see LaBelle,A. 193, Triggle,e.R., see Moran,J.F. Thomas, H. V., Simmons, E. 211, 381, 409,431, 448, 494, 325,331 143,149 532,558 Triggle,D.J., see Moran,J.F. Thomas,J. W., Kelley,F.R. Tislow,R., see Spoerlein,M. T. 295,320,324,325,331 183,213 450,501 Tripod,J., Wirz,E., Meier,R. Thompson, B. 1., see Tissier,e., Tissier,M. 267,293 7-9,11,12,38 Brimblecombe,R. W. 178, Tissier, M., see Tissier, C. 267, Trippestad,A., Midtvedt, T. 208 293 575,602 Thompson,D.P., see Moore, Titus, D. e., see Porter, e. e. Tristani,F. E., see Cohn,1. N. T.e. 143,147 543,544,558 579,597 Author Index 649

Trolin,S., see Morren,H. 185, Udenfriend,S., Waalkes, T. P. Vajda, P., see Karady,S. 369, 212 475,502 370,379 Trolliet,J., see Halpern,B. N. U denfriend, S., see Brodie, B. B. Valen tine, M. D., Bloch, K. J., 471,491 514,521,554 Austen,K.F. 60,74 Trottier,R. W., Malone, M. H. Udenfriend,S., see Keston,A.S. Valentine, M. D., see Austen, 199,213 152,172 K.F. 60,69 Trotter,J., see Veidis, M. V. Udenfriend,S., see Waalkes, Valette,G., see Schwartz,J.-e. 182,214 T.P. 470,503 112,118,129 Trousof,N., see Burns,J.J. 552. Vallery-Radot, P., Bovet, D., 555 Ueda,1., see Kikkawa, M. 520, 557 Maurie,G., Holtzer,A. Truax,J.F., see Vinegar,R. 405,436 Uhlig,R., see Lorenz, W. 143, 507,512 Vallery-Radot, P., Hamburger, 147 Truscoe, R., see Zwemer, R. L. J.,Halpern,B.N. 409,436 Umezawa,Y., see Okuma,T. 468,504 Vallery-Radol. P., Maurie, Goo 562, 566, 572 Truter, M. 266,293 Halpern, B. N. 389,421, Truter, M.R., see Kunchur, N. R. Ungar,G. 405 436 259,268,291 Ungar,G., Parrot,J.L. 3R9 Van Arman,e.G., Bohidar, M. Tryding,N. 134,139,149 Ungar,G., Parrot,J.-L.,Bovet, D. 505,506,508,512 Tryding,N., see Hansson,R. 179,214,389,436 Van Arman,e.G., Risley 506 134,145 Unger,S. H., see Hansch, e. Van Breemen,e. 65,74 Tsai,I., see Kuntzman,R. 521, 334,358,366 Van den Brink,F.G. 253,283, 526-529,531,558 Urquilla, P.R.,Marco,E.J., 293, 333, 335, 344, 352, 358, Tsajaris, T. J., see Anderson, L1uch,S. 27,38 364,365,367,390,416.419, F. L. 584, 596 Usami,S., see Chien,J. 583, 436 Ts'o, P. O. P., Melvin, I. S., 596 Van den Brink,F. G., see Offer• Olson,A.e. 279,293 Uvnas,B. 57,74,78,82,87,89, meier,J. 365,367 Tuck,S., see Abramson, D. I. 6, 91,92,93,108 7,22,30 Van den Brink,F.G., see Van Uvnas,B., Aborg,e.-H. 75, 82, Rossum,J. M. 333,334,367 Tucker, A., Hoffman, E. A., 85-87,92 Vandenheuvel, W.J.A.,see Weir,E.K. 469,502 Uvnas,B.,Aborg,e.-H., Bergen• Tucker, A., Weir,E.K., Reeves, Porter,e.e. 543,544,558 dorff,A. 58, 74, 75, 82, 85, Vander Brook, M.J.,Olson, J.T., Grover,R.F. 5,15,21, 86,92 38,469,502 K. J., Richmond, M. T., U vnas, B., Aborg, e.-H., Berg• Kuizenga,M.H. 197,214, Tiirker,R.K. 440,454,502 qvist, U. 84,92 Tiirker,R. K., see Bokesoy, T. A. 388,437,450,455.502 Uvnas, B., Thon, I. L. 58,59,74, Van der SteIt,e., Harms,A. F., 18,32 75,92,93,108 Tiirker,R. K., see Ercan,Z.S. 9, Nauta,W.Th. 199.200,214 Uvnas,B., Wold,J.K. 78,92 Van der Vlies, e. 178,214 12, 14, 21, 27, 34, 457-459, Uvnas,B., see Aborg,e.-H. 86, 470,487,593,597 87,90 Van der Waals 360,362,402 Tull,L.N., see Swineford,O.,Jr. Uvnas,8., see Anderson, P. 59, Vane,J.R. 507,512 466,502 69,79,90 Vane,1. R., McGiff,1. e. 584, Tumpson,D.B., Johnson, L. R. Uvnas,B., see Andersson,S. 80, 602 47,56 90 Vane,J. R., see Collier, J. G. Tumpson,D.B., see Johnson, U vnas, B., see Bergendorff, A. 584,597 L.R. 47,56 58,69,86,90 Vane,J.R., see Ferreira,S.H. Turnbull,L.B., see Bruce,R.B. Uvnas,B., see Bergqvist, U. 78, 507,511 535,555 82,85,90 Vane, J. R., see Moncada, S. Turnbull, M.J., Kelvin,A.S. Uvnas, B., see Chakravarty, N. 506,507,511 140,141,149 93,107 Vane,1.R., see Piper,P.J. 463, Turner,C.D., Bagnara,J.T. Uvnas,8., see Diamant, B. 59, 499 585,602 7(), 79,90,93,95, 107 Vane,1.R.,seeStaszewska• Turner, P., see Hedges,A. 566. Uvnas,B., see Frisk-Holmberg, Barczak,J. 463,501 571 M. 78,90 Vanhoutte, P. M. 27, 29,38 Tusing, T. W.,see Lunsford, Uvnas,B., see Guschin,I.S. 79, Vanhoutte, P. M., see Shepherd, e. D. 449,454,496 90 J.T. 1,27,29,38 Tuttle,R.S. 23,38 Uvnas,8., see Moran,N.e. 58, Van Loon,E.J., see Kamm,J.J. Tyce, G. M., see Navert, H. 72,78,91 533,557 133,147 Uvnas,B., see Nosal,R. 88,91 Vanremoortere,E., Lecomte,J., Tyner,J., see Woods,J. R. 20, U vnas, B., see Rohlich, P. 59, Mazzella, H., Nelemans,F. 39 73,79,91 471,503 Uchida, M., see Takagi, K. Uvnas,8., see Slorach,S.A. 59, Vanremoortere,E., see 295,332 73, 106,108 Lecomte,J. 459,494 Uchida, T., see Kuriaki, K. Uvnas, B., see Thon, I. L. 58, Van Rossum,1. M. 333,334, 462,463,493 73,75,79,82,86,91 364, 367, 380 650 Author Index

Van Rossum,J.M., Van den Vermeil, G., see Halpern,B. N. Waalkes, T. P., Coburn, H. 474, Brink,F.G. 333,334,367 444,491 503 Van Rossum,J.M., see Ariens, Viaud,P. 214,381,389,409,437 Waalkes, T. P., Weissbach, H., E.J. 252,283,287,324,329, Vick,J.A. 587,602 Bozicevich,J., Udenfriend,S. 343,345,365,366 Vick,J.A., Mehlman, B., Heifer, 470,503 Van Rossum,J.M., see Ellen• M. H. 60, 74, 585-587, 602 Waalkes, T. P., see Sjoerdsma,A. broek,B. W.J. 352,366 Vick,J.A., see Hinshaw,L.B. 168,173 Varga,E., see Went,S. 400,437 586,587,599 Waalkes, T. P., see Udenfriend, Vargha,L., see Toldy,L. 198, S. 475,502 213 Vickers, M. R., see Assem, E. S. K. Wagner,J., Reinhardt,D., Vassanelli,P., see Kato,R. 550, 106,106, 113,123 Huppertz, W. 27,29,39 557 Villani,F.J., Daniels, P.J. L., Vasseur,B., Nicot,G., Parrot, Ellis, C. A., Mann, T. A., Wagner,J., see Reinhardt,D. J .-L. 372, 374,380 Wang,K.C. 200,214 12,27,37,401,434,440,457, Vasseur,B., Pelletier,G. 375 Villani,F.J., Daniels,P.J.L., 458,499 Vaughan,J.H., see Matsumara, Ellis, C. A., Mann, T. A., Wahner, W. H., Peters, C. A. Y. 474,496 Wang,K.-c., Wefer,E.A. 197,214 Vaughan,J.R., Anderson,G. W., 200,214,474,503 Wajda, I., see Ing,H.R. 416, Clapp,R.C., Clark,J.H., Vinegar,R., Macklin,A. W., 430 English,J. P., Howard, K. L., Truax,J.F.,Selph,J.L. 507, Wajda,L., see Biilbring,E. 417, Marson, L. H., Sutherland, 512 426 L.H., Denton,J.J. 180,214 Vinegar,R., Schreiber, W., Hugo, Wake, K., see Saeki, K. 440, Vaughan,J.R., see Clapp,R.C. R. 507,512 500 180,208,409,427 Virtue,C. M., see Cook, T.J. Wakim,K.G., Peters,G.A., Vaughan,M., see Stoner,J. 64, 421,427 Terrier,J.C., Horton,B. T. 73 Vitali, T., see Erspamer, V. 133, 19,39 Vaysse, N., see Pascal, J. P. 145 Wakkary,J.A., Goodfriend,L., 17,37 Vitolo, E., see Melli, G. 456,497 Kovacs, B. A. 378,380 Vaz, N. M., Prouvost-Danon,A. Vogel,S., see Josephson,I. 401, Waldenstrom,J., see Granerus, 57,74 431 G. 141, 143, 145 Vaz,N. M.,see Iff,E.T. 474,492 Vogt, W. 300,332,452,503 Walker,J. 257,293 Veals,J., see Korduba,C.A. Vogt, W., see Bodammer,G. Walker,J., see Kennard,O. 567,571 443,452,463,482 257,291 Veals,J., see Symchowicz,S. Voith,K.,seeKovacs,B.A. 376, Wall,M., see Joiner,P.D. 454, 567,573 378,380 455,493 Vegt,G. T.B.,see Roozemond, Volicer,L., see Mathe,A.A. Wallace,K.H., see Scott,R.S. R. C. 548, 558 478,496 566,572 Veidis,M.V., Palenik,G.J., Von Euler,U.S. 20,38 Wallis,D.I., see Brimble,M.J. Schaffrin,R., Trotter,J. Voss, H., see Clowes,G.H.A., Jr. 440,483 182,214 575,597 Walsh,J.H., see Richardson,C. Veigel, H., see Brock, N. 183, Votava,Z., Metysova,J., T. 265,292 208,446,465,483 Horakova,Z. 201,214 Walter, W., Ruess, K. P. 269, Vejdelek,Z.J., see Protiva,M. Votava,Z.,seeHorakova,Z. 293 201,212 201,210 Walter, W., Schaumann,E., Velasquez,B.L., JaI6n,P.D.G. Votava,Z., see Metysova,J. Rose,H. 269,293 387,388,437 200-202,211,212 Walthert,F., see Bovet,D. 180, Venables,C. W., see Harris,D. Votava,Z.,seeProtiva,M. 201, 208, 381, 389, 399, 405, 406, 264,290 212,220,248 409,412, 416, 424,426 Venables,C. W., see Reed,J.D. Vries, K. de, see Pelikan,Z. 509, Walthert,F., see Halpern,B.N. 21,37,49,50,53,56 511 180,210 Venables,C.W., see Thompson, Vroom, F. Q., Brown,R. E., Waitin,J., see Bloch,K.J. 63, M. H. 265,293 Dempsey,H., Hill,S.R.,Jr. 69 Vercauteren,R. 369, 380 543,559 Wan, B. Y. c., Assem,E.K., Vercauteren, R., Peeters, G. Vugman,1. 386,437 Schild,H.O. 265,293 369,380 Vugman,l., Prado,M.L.M. Wang,K.C., see Villani,F.J. Verdiere-Sahuque, M., see 442,503 200,214,474,503 Schwartz,J.c. 133, 148 Vugman, I., Rocha e Silva, M. Wang,S.C., see Jaju,B.P. 567, Verloop,A., Hoogenstraaten, W. 151,173 571 Tipker,J. 363,367 Vugman,I., see Mota,1. 443, Wangensteen,S. L., see Glenn, T. Verma,S.C., McNeill,J.H. 497 M. 598 441,459,503 Vugman, I., see Rothschild,A. M. Ward,C.S., see Glazko,A.J. Verma,S.c., see McNeill,J. H. 93,108 514,518-520,556 9,12,36,400,401,433,440, Vurek,G.G., Prager,D.J., Ward,J. W., see Lunsford,C.D. 458,459,497 Feigen,G.A. 459,503 449,454,496 Author Index 651

Ward,V.G., see Welsh,1.D. Way,E. L., see Dailey,R.E. Weiss,G.B., Goodman,F.R. 471,503 515,516,555 65, 74 Wardell,J. R., J r., see Chakrin, L. Way. L. W., see Aures,D. 44, Weiss,R. 199,2/4 W. 440,484 45,55 Weiss, S., Ellis, L. B., Robb, G. P. Warin.R. P .. see Bain. W.A. Weaver.S.A., see King,C.T.G. 7,8,39 389,409,421,425 526,527,558 Weiss,S., Robb,G. P., Blumgart, Waringa,e.G. 193,202,214. Webb, E. c., see Dixon, M. 301. H.L. 6,7,19,39 225,237,238,249 330 Weiss,S., Robb,G.P., Ellis,L.B. Waringa,C.G., Rekker,R.F., Webb, W. R., see Mengoli, L. R. 2, 6-8, 12, 39 Nauta,W.Th. 216,225, 581.600 Weissbach, H., see Sjoerdsma,A. 233,237,238,249 Weber, H. P., see Ebnother.A. 168,173 Waringa,e.G., see Rekker,R.F. 234,246 Weissbach, H., see Waalkes, T. P. 216, 234,248, 388, 397, 398. Webster, M. E., Maling, H. M., 470,503 403, 404, 434 Zweig, M. H., Williams, M. Weissberg,J., see McGavack, T. Warner,R.R.P., see Gilbert,H. A .. Anderson, W., Jr. 508. H. 183,211 S. 142,145 512 Weissenbacher, B., see Lorenz, Warren,B.J.. see Roy,A.C. 64, Webster, M. E., Newball, H. H., W. 143,147 73 Oh-[shi,S., Takahashi, H., Weissmann,G., see Bourne,H. Warren, K.S., see Kellermeyer. Horakova,Z., Atkins, F. L.. R. 61,69 R.W. 510,511 Beaven.M.A. 163. 164, Weisz,l., Dudas,A. 195,214 Wasmuth, W., see Ackermann. 167.173 Wells,J.A., Morris,H.e. 389, D. 369, 378, 381. 399, 405. Webster. M. E .. see Maling, H. 409,437 425,442,455,480 508. 510,511 Wells,J.A., Morris,H.C., Bull, Wasserman, L. R., see Gilbert, H. Weeks.R.E., see Gunnar.R.M. H.B., Dragstedt,e.A. 251, S. 142, 145 591. 593, 598 293 Wasserman, L. R., see Krauss, S. Wefer.E.A., see Villani,F.J. Wells,l.H., Morris,H.c., 110, 126 200.214,474,503 Dragstedt, C. A. 389, 409, Wasserman,S. I., Goetzl, E.J., Wegmann. A., Renker,H. 471. 412,437,469,503,591,602 Austen,K.F. 78,92 503 Wells, P. W .. Eyre, P. 476, 503 Wasserman, S.I., Goetzl, E. J .• Wegmann, A., Renker, H .. Hiib• Wells, P. W., see Eyre, P. 476, Ellman, L., Austen, K. F. scher, H. 471,503 477,487 58, 74 Wegria,R.G. E., see Essex,H. E. Wells,R., see Hutchins,P.M. Wasserman, S.I., see Goetzl, E. 1. 13. 14,34 580, 581, 599 378,379 Weidmann, H., Grauwiler.1., Welsh,l.D., Ward,V.G., Wasserman,S. I., see Kaliner, M. Griffith, R., Romer, D., McFadden,H. W., Jr. 471, A. 64,71 Taeschler, M .. Zehnder, K. 503 Watkins,J. e. 227, 249 523,559 Wempen, I. M., see Titus, E. O. Waton,N.G. 114,115,129 Weidmann, H., Petersen, P. V. 521,559 Waton,N.G.,see Adam,H. M. 562. 567, 573 Wenger, H. e., see Engelhardt, E. 114, 122 Weidmann. H., see Romer.D. L. 199,209,543,555 Waton, N. G., see Duncan,J. C. 450,500 Wenger, H. c., see Stone, C. A. G. 114.123 Weidmann,S. 419. 420. 437 199,213,443,502.507,512, Waton,N.G., see Lippert,T.H. Weigle. W.O., Cochrane,e.G .. 543.559 114, 126, 134, 138, 146 Dixon, F. J. 468,503 Wenk,P., see Huebner,C.F. Waton,N.G., see Pearlman,D. WeikcU.H.Jr., Wheeler,A.G., 202,210 S. 110,/27 Joiner. P. D. 540, 559 Wenner, W., see Plati,J. T. 203, Watson,B.H., see Scott,R.S. Weil,M.H., Bradley,E.e. 57X. 212 566,572 M)l Went,M.,seeCsaba,B. 134, Watts,D.J., see Peach,M.J. Weil. M. H .. Shubin, H. 577, 144,471.472,474,486 583,601 579.602 Went,S., Varga, E., Sziics,E .. Waud,D.R. 295,332,397,437 Wei!. P .. see Rose, B. 585,586, Feher,O. 400, 437 Waud,D.R., Parker,R.B. 325. 588.601 Werle, E., Amann,R. 83,92 332,393,394,396,437 Weiner.R., see Messina.E.J. Werle, E., Kopp, K .. Leysath, G. Waud,D.R., see Parker,R.B. 23.36 198,214 325,331,394,397,433 Weinfeld. A., see Westin,]. 142, Werle, E., Lorenz, W. Ill. 129 Waud,D.R., see Paton, W.D. M. 149 Werle, E., see Amann, R. 83,90 296,300,326,331 Weinman,E.O., Geissman.T.A. Werle, E., see Lorenz,W. 109, Wax,S. D., see Mengoli,L.R. 524,525.526.559 Ill, 119,126, 132. 139,146, 581,600 Weinstein, R., see Peets. E. A. 147 Way,E.L., Dailey,R.E., 513, 533,558 Werner,H.W., see Brown,B.B. 520,523,524,559 Weir, E. K .. see Tucker,A. 5, 387,389,409,426,446,463, Way,E. L., Overman.J. R., 15, 21, 38, 469, 50] 467, 474, 483 Howie,D.L. 514,516,518. Weiser,R.S., see Tokuda.S. Werner, H. W., see Snyder, F. H. 559 475,502 515,559 652 Author Index

Werner,M., see Carter,D.e. Wetterqvist, H., see Jonassen, F. Wilcox, H. B., Jr., Seegal, B. e. 265,288 135, 138, 141,146 9, 13, 14,21,39,409,437,445, Wessman,e.G., see Schmiter• Wetterqvist,H., see Lowhagen, 450,503 IOw,e.G. 444,501 O. 142,147 Wilcox, H. B., J r., see Andrus, E. West,G.B. 469,503 Wetterqvist,H., see Norinder,B. e. 456,481 West,G.B., see Akcasu,A. 469, 135, 143, 147 Wilhelm,D.L. 422,423,437, 480 Wetterqvist, H., see Sixt,R. 510,512 West,G. B., see Dawson, W. 141,148 Wilhelm,D.L., Mason,B. 501, 135, 144, 472,486 Wetterqvist, H., see Svensson,S.• 512 West,G.B., see Fearn,H.J. 2, E. 110, 114, 129, 138, 141, Wilhelm,D. L., see Craig,J. P. 4,34 149 442,467,485 West,G.B., see Radwan,A.G. Wetterqvist,H., see Westin,J. 110,116,127 142, 149 Wilhelm,D.L., see Miles,A.A. West,G.B., see Sanyal,R.K. Wetterqvist, H., see Westling, H. 422,433 83,91,471,472,474,500,501 134, 138, 141, 149 Wilk,A.L., see Narrod,S.A. West, G. B., see Starr, M. S. 472, Wheeler,A.G., see Weikel,J.H. 526, 527, 531,558 501 Jr. 540,559 Wilk,A.L., see Posner,H.S. Westerfeld, W. W., see Coccia, P. Whelan,R.F., see Duff,F. 19, 529,558 F. 521,555 33,422,428 Wilk,A.L., see Steffek,A.J. Westerholm,B. 93,108 White,A. e., Green,A. F., 529,559 Westerholm, B., see Moran, N. e. Hudson,A. 189, 214, 226, Wilken-Jensen, K. 183,214 58, 72, 78, 91 249 Wilkens,H.J., Back,N. 469, Westin,J., Granerus, G., Wein• White,G.R., see Durant,G.J. 503 feld, A., Wetterqvist,H. 285,288 Wilkinson, G. R., see Beckett,A. 142,149 White,J.G. 68,74 H. 532,554 Westling,H. 134,139,140,141, White,R. P., Boyajy, L. D. 562, Williams, B., see Diamond, L. 149 567,573 410,428 Westling, H., Wetterqvist, H. White, T. 131, 133, 137, 149, Williams,G.J.B., see James,M. 134, 138, 141,149 150,568,573 N.G. 191, 195, 196,210, Westling, H., see Berg,B. 115, White, T., see Agrup, P. 142, 211,236,247 123,140,142,143,144 143 Williams,J.G., see Milton• White, T., see Berg, B. 115, 123, Westling, H., see Bjuro,T. 113, Thompson,G.J. 265,292 114, 119, 123, 134, 138, 141, 140,142,143,143,144 Williams, M.A., see Maling,H. White,T., see Granerus,G. 144 508, 510, 511 131,140,141,143,145 Westling, H., see Granerus,G. Williams, M. A., see Webster, M. 141, 143, 145 White, T., see Wetterqvist, H. E. 508,512 Westling, H., see Hansson,R. 131, 13~ 13~ 13~149 Williams, P. e., see Cutting, W. 134,145 Whitehouse, M. W., see Skid• e. 16,33 Westling,H., see Helander,e.G. more,L.F. 116,129 Williams, R. D., see Feinstone, 139,145 Whitmire,R.N., see Dennis,R. W.H. 180,209,381,409, Westling, H., see Kahlson,G. G. 26,33 429,447,487 137,146 Wiberg-Wetterqvist,A. K., see Williams,R.J. P. 65, 74 Westling, H., see Lindberg,S. Sixt,R. 141, 148 Williams,R.T. 520,559 119,126 Wiebelhaus, V.D., see Sachs,G. Williams,R.T., see Robinson,D. Westling, H., see Lindell,S.-E. 46,56 520,558 110, 126, 139,146 Wieczorek, W., see Hanahoe, T. Williams, R. T., see Scheline, R. Weston,A.W. 180,214 H.P. 64,71 R. 554,559 Wetterqvist,H. 134-136, 149 Wieland,D.M., see Chastain,R. Williams,R. T., see Smith,R. L. Wetterqvist, H., White, T. 131, V. 276,288 559 135, 137, 138, 149 Wieland,D.M., see McCarty,e. Williams, T.J., Morley,J. 506, Wetterqvist,H., see Agrup, P. G. 266, 274, 275, 292 512 142, 143 Wiemann,H.M., see Reinhardt, Willoughby,D.A., see Di Rosa, Wetterqvist, H., see Berg, B. D. 440, 457, 458, 500 M. 507,508,511 143, 144 Wiggers, H. e., Ingraham,R. e., Willoughby,D.A., see Spector, Wetterqvist, H., see Bjuro, T. Roemhild, F., Goldberg, H. W.G. 508,512 113,114,119,123,134,138, 578,602 Wilson,J. W. 580, 581,602 144 Wiggers, H. e., see Ingraham, R. Wilson,J. W., see Free, S. M. Wetterqvist, H., see Granerus, G. e. 589,590,599 231,246 131,135,136,139,140--142, Wijngaarden,1. van see Soudijn, Wilson, M. L., see Glazko, A. J. 145 W. 531,559 514,518-520,556 Wetterqvist,H., see Hansson,R. Wilbrandt, W. 301,332,387, Wilson, R. F., Jablonski, D. V., 134,145 437 Thal,A. P. 578,602 Wetterqvist, H., see Johansson, Wilcox,H.B., Jr., Andrus,E.e. Wilson,R.F., see Fromm,S. M.-B. 110,125 456,503 578, 598 Author Index 653

Winbury,M.M., Alworth,B.L. Woodruff,G. N., Oniwinde,A. Yamasaki,H., see Tasaka,K. 419,437 B., Kerkut,G.A. 133, 150 59, 73 Win bury, N. N. 459, 503 Woodruff,G. N., see Huggins,A. Yao,H., see Diana,J.N. 26,33 Winder,e.V., Kaiser,M.E., K. 133,145 Yarnal,J.R., Hollis,T.M. 23, Anderson, M. M., Glassco, E. Woods,A.M., see Farmer,J.B. 39 M. 183,214,390,409,413, 472,487 Yasuda, M. 459,504 416,437 Woods,J.R., Jr., Brinkman,e. Yee,R., see Mock,).E. 566,572 Window,J., see Casley-Smith,J. R. III, Dandavino,A., Mura• Yellin,T.O.,Sperow'). W., Buck, R. 423,427 yama,K., Assali,N.S. 469, S. H., Johnson,E. M., Jr. Winklemann,R. K., Sams, W. M., 503 506,512 Bohr,D.F. 27,39 Woods,).R., Brinkman,e.R., Yen,S.-S., Mathe,A.A., Dugan, Winklemann, R. K., Sams, W. M., Tyner, J., Martinek, H., J.J. 443, 444, 504 King,J.H. 27,39 Assali,N.S. 20,39 Yen,S.-S., see Mathe,A.A. 443, Winqvist, G., see Aures, D. 110, Woolfe,G., see MacDonald,A. 496 123 D. 585-587,600 Yonkman,F.F., Chess,D., Winter, e. A. 406,409,437,444, Worsmsley, K.G., see Thjod• Ma thieson, D., Hansen, N. 503,562,573 leifsson, B. 265, 293 462,504 Winter,e.A., Flataker,L. 464, Wragg, W.R., see Edge,N.D. Yonkman,F.F., Hays,H.W., 503,562, 573 197,209 Rennick,B. 409, 437, 469, Winter,e.A., Richards,G. V. Wrenn, T. R., Bitman,)., Cecil, 504,591,602 465,503 H.e., Gilliam,D.R. 137, Yonkman, F. F., Oppenheimer, Winternitz, W. W., Hackel,D. B. 150 E., Rennick, B., Pellet, E. 471,503 Wright,J. B., see Reid, W. B. 453, 469, 504 Wirz, E., see Tripod,). 7-9, 11, 197,212 Yonkman,F.F., Roth, F., Smith, 12,38 Wright,S.H.B., see Durant,G.J. J., Hansen,N., Craver,B.N. Wissler,)., see Bernauer, W. 254,289 417,437 459,472,482 Wuis,P.J. 249 Yonkman,F. F., see Craver,B. N. Withrington, P.G., see Richard• Wurm,A., see Kukovetz, W.R. 447,462,486 son,P.D.1. 469,500 401,431 Yonkman, F. F., see Rennick, B. Witiak,D.T. 175,198,201, Wycz6Ikowska,J., see Czer• 453,500 202,214,215,240,245,249 willska, U. 478,486 York,D.H.,see Phillis,J. W. Witiak,D.T., Hsu,S.Y., 011- Wyllie,J. H., Ealding, W. D. P., 568,572 mann,J. E., Griffith,R. K., Hesselbo,T., Black,J.W. Yoshinaga, M., see Hayashi, H. Seth, S. K., Gerald, M. e. 265, 281,293 471,492 204,214 Wyllie,J. H., Hesselbo, T. 50, Young,D., see Chakrin,L.W. Witiak, D. T., Muhi-Eldeen, Z., 56,259,265,281,293 440,484 Mahishi, N., Sethi, O. P., Wyllie.J. H., Hesselbo, T., Black, Young,J.M., see Lehmann,G. Gerald,M.e. 204,214 J. W. 293 413,43/,442,453,456,466, Witiak,D.T., see Gerald,M.e. Wyllie,J. H., see Black,). W. 495 204,209 263265,287 Young,J.M., see Reashbeck,P. Wittig,H.J., see Cook, T.J. Wyngaarden,J. B., Seevers, M. G. 413,434 421,427 H. 534,560,561,573 Young, P. R., see Kimura,E.T. Wynn, W., see Cohn, V. H. 134, Wold,J. K., see Uvnas, B. 78,92 443,448,493 144 Young,R.e., see Bowden,K. Wold,J.S., Fischer,L.J. 543, Wysocki, A., see Konturek,S.J. 177, 208 560 50,56 Young, R. H., Gilbert, R. P. Wolf,J., see Schwartz,E. 421, 453,504 435 Xhonneux,R., see Schaper, W. Yuen,L., see Aures,D. 123 Wolfgram,F., see Nakajima,T. K.A. 531,558 Yuen, L., see Johnson, L. R. 45, 133,147 55 Wollenberg, A., Schulze, W., Yale,H.L., Sowinski,F. 202, Krause, E.G. 401,437 214 Zaagsma,J. 217 Wong,D.,seeBecker,E.L. 443, Yamaguchi,M. 454, 504 Zacchei,A.G .. see Hucker, H. B. 444,473,481 Yamamoto,S., Francis,D., 543-545,557 Wong,D.,seeGalant,S.P. 421, Greaves, M. W. 478, 504 Zaher, e., see Chakrin, L. W. 429 Yamasaki, H. 455,504 440,484 Wong,S.T.K., see Cotton,F.A. Yamasaki, H., Muraoka,S., Zahradnik, H. P., see Hahn, F. 257,288 Endo, K. 93, 108 445,448,451,460,461,463, Wood,e.J., Simkins,M.A. Yamasaki,H., Tasaka,K. 442, 490 552,560 5()4 Zar, M.Aboo, see Ambache, N. Wood,D.R., see MacGregor,A. Yamasaki,H., see Saeki,K. 440,456,481 G. 471,496 440,500 Zarkower,A. 137,150 Woodcock,B.G., see Shepherd, Yamasaki, H., see Sugiyama, K. Zarkower.A., Dunlop,R. H., D.M. 111,114,129 58. 73, 79, 91 Norcross,N.L. 137,150 654 Author Index

Zavecz,]. H., see Levi,R. 1,35, Ziebell,A., see Diamant,B. Zuskin,E., Lewis,A.J., Bouhuys, 443,460,495 104, 107 A. 398,437 Zaw,K., see Eaton,D.R. 279, Ziegler,D.M., Pettit,F.H. 521, Zweifach, B. W. 1,23,24,26,39, 289 560 575,578,580,581,602 Zayas,A.M., see Abramson,D.I. Zierdt,C. H., see Horakova,Z. 6,7,30 167,172 Zweifach, B. W., see Altura, B. M. Zilletti, L., see Dale, M. M. 455, 1,23-25,28,31,121,123,462, Zederfeldt,B., see Lindell,S.-E. 481 110, 126 486 Zimmermann,B.G., see Kraft,E. 575,579,584,585,595,596 Zeegers, A., see Aarsen, P. N. 19,35,462,493 Zweifach, B. W., see Aschheim, E. 15,30 Zippin,C., see Galant,S. P. 423,425 Zehnder, K., see Weidmann, H. 421,430 523,559 Zweifach, B. W., see Janoff, A. Zischneid, W., see Clowes, G. H. 576,599 Zeidel,M., see Maudsley,D.V. A., Jr. 575,597 444,496 Zweifach,B. W., see Shorr,E. Zucker, M. B., Peterson,]. 68, 575,602 Zell, H. c., see Engelhardt,E. L. 74 199,209,543,555 Zuelzer, see Miiller,E.A. 14, Zweig, M. H., see Webster, M. E. Zeller,E.A. 133,150 15,36 508,512 Zeuthen, E., see Chakravarty, N. Zurier,R., see Bourne,H.R. 61, Zwemer,R. L., Martorano,J.J., 95,98, 102, 107 69 Truscoe,R. 468,504 Subject Index

Absorption of AH (see Antihistamine (s), ab- Adenine, action on cAMP 62 sorption) 513ff. nucleotides 582 Acetic anhydride, 14C or 3H labeled 153 Adenosine nucleotides 582 Acetonitrile 286 triphosphate (see ATP) Acetophenone 184, 186 S-Adenosylmethionine Acetylcholine 24,28,299, 304, 327, 328, 381, 14C-methyl 109, 154, 160, 162, 165, 169, 390,399,413,414,416,454,456,509,575, 170 582 enzyme mixture 157, 158, 160 action on antigen-induced hist. reI. 64 purity 161, 164 action of NAS 370, 375 endogenous 109, 163, 164 aerosols 465 3H 161, 162, 165 hist. reI. by 43 enzyme mixture 157, 158, 161 and hist. and pentagastr. stirn. gastric secre• Adenylate cyclase system 459 tion 50 Adenyl compounds 576 inhib. of gastric stirn. by 54 Adenylyl cyclase prep. (g. pig fundus mucosa) as mediator of parasympathetic terminals 458 386 Adrenalectomy 374, 375,462-464,472,479 receptors (muscarinic) 260, 424 Adrenaline (see also epinephrine) 113, 119, sensitivity 466 374 turnover in brain 120 and HFC 110 N-Acetyl-glucosamidase 78,88,89 as mediator of sympathetic terminals 386 Acetylhistamine 131 Adrenal medulla 400 2-Acetylpyridine 184, 203 Adrenals and adrenergic system, role in ana: Acid polymers, as degranul. agents 78 phylaxis, action of AH 461-466 Acid secretion [see also gastric (acid) secretion] and hist. reI. 48 catecholamine content in protracted shock 464 effect of compound 48/80 48 effect of Triton-X-100 48 Adrenergic amines, aerosols and asthma 466 inhib. by burimamide 49 Adrenergic p-agents 165,254,365,477,478 stirn. of 42 agonists, as inhibitors ofhist. reI. 61,67 Actinomycin D 114, 118 IX-antagonists 3 and HDA 118 IX- and P-blockers 280 relation to RNA synthesis 118 P-blockers 254 Active cutaneous anaphylaxis (see Anaphyla• IX-Adrenoceptor(s) 322 xis, active cutaneous) blocking activity 362 Acute shock, anaphylactic IX-Adrenolytic agents 390 AH in 445,451,472,478,479 Aerobic glycolysis 97 and catecholamine reI. 461-464,479 medium, enhancement of hist. reI. 98

Abbreviations AAch Antiacetylcholine HLP Heart-lung preparation Ach Acetylcholine NAS Naturalo antihistaminic substances AH Antihistamine(s); antihistaminic(s) PCA Passive cutaneous anaphylaxis cAMP Cyclic adenosine monophosphate QSAR Quantitative structure-activity CNS Central nervous system relationships HD Histidine decarboxylase RES Reticulo-endothelial system HDA Histidine decarboxylase activity RF Reticular formation HFC Histamine forming capacity SAR Structure-activity relationships 656 Subject Index

Affinity (to receptors) 333,334,341,342, pA2 values 220-225 345-348,350,352-354,362-364 SAR 219 changes 316, 319, 324 tertiary 182 ff. constants (Kp) 178ff., 296, 297, 301,325 4(5)-(4-Aminobutyl)irnidazole 285 practical 364 Aminoethylaniline 382, 386, 405 overall 296,297,310,316,328 4-(2(fi)-Aminoethyl)-pyrazole 338, 342 in regression analysis 356-360 Aminoethylether deriv. 382 and Jipophilicity 362 action on CNS 566 metactoid 351 QSAR 360-363 parameters 296, 303, 323, 328, 391, 395 3-fi-Aminoethylpyrazole 342, 344 of population 341 2-fi-Aminoethylpyridines 336,343,344 values 340-344, 346, 347, 351, 355 2-fi-Aminomethylpyridine 342 correlation for diff. receptors 365 Aminoguanidine 116, 117, 133-138 infl. molec. modifications 351-360 140,141,143,163,472 Agonist(s) 295-297 Aminophylline 398,453,463,466,468,477 antagonists, equilibrium 301,329 3-Aminoprop-l-ene deriv. 192, 241 interaction 328 affin. constants 192 SAR 344, 345 2-Aminopyridine 180 chemical potential 297,312 Aminopyrine 477, 509 concentration effect 333 metabolism and action of orphenadine 552 dissociation constant (Clark'sconstantJ 391 Amitriptyline 543, 545, 546 full 340 compar. disposition in rat and man 545 interaction with hist. receptor 342-345 N-demethylation 545, 547 maximum response 298,301 N-didemethylation 545 (dualist) 326, 333, 340 hydroxylation 545, 547 receptor area 343 levels in organs, human 545 relationship 333 metabolic studies 543-546 Albert and Serjeant form 176 metabolites 545 Alkylamine agents, action on CNS 564, 565 urinary, rat, man 545 Allercur (see also clemizole) 180,415,418 N-oxidation 545, 547 Allergen 142 Amplictil (see also chorpromazine, thorazine, Allergic asthma, treatm. with dis odium cromo• largactil, 4560 RP) 388 glycate 64 Amy tal sodium 94 Allergy 405 Anahist (see also neohetramine, thonzylamine) action of AH 389,421, 507, 509 381,383,408,415,418 of NAS 378 Analgesia 507 human 386, 389 Analgesics 549 manifestations 389 Anaphylactic contraction, action of AH Allograft rejection, and hist. formation, rat isol. atrium 457 skin 116 isol. gut 455, 456 Aluminium hydroxyde gel 472 g. pig, diff. segments 399 Alvarine 338 isol. trachea 454, 455 Amethobenzepine 201 isol. uterus 456, 472 Amine oxidase 463 hist. reI. (see also Histamine release, anaphy• Amine(s) lactic) 93-95,97,98, 100 biogenic 390 ATP content, rat mast cells 101,102, equivalent exchange in granules 86 104, 105 uptake by granules 86 and energy metabolism 105 displacement of, in hist. reI. 58 inhib. by catecholamines 113 release from platelets 68 reaction, action of AH 399,475 action of trypsin 68 glucose metabolism 99 of various subst. 68 heart, biphasic 460 by catecholamines 68 iso\" perfused 456 role of ADP 68 Anaphylactic reaction and hist. rei., mast cells of cAMP 68 93 Amidinium structures 257, 258 production by diff. substances 399 Aminoalkylether derivatives 216,532 reaginic type 105 Subject Index 657

Anaphylactic in guinea pig 478 uterus, mouse 475 heart 440, 478 shock (see also Anaphylaxis) 134 heart 456-461, 478 acute 445 histamine release in 386,441,508 AH in 441, 446-450 and AH action 443 in calves 588 in horse 477 correl. with blood hist. 588 local (Arthus phenomenon) and AH 412 in cortisone-treated animals 588 mediators of 509 in dogs 588, 590 in mice 474 effect of resupinization 462 non-histamine components 442-444,454, in fowl 588 478 in guinea pig 588, 590 passive cutaneous (peA) 412,473, and hist. metabolism 134 476-478, 509 in horses 588 distinction from Arthus reaction 412 increased heparin titer in 88 enhancement by phosphatidylserine 63 in mouse 591 hemocytotropic 412 protection by AH 406-412,591,594 heterologous 467,473,475,479 protracted 445 reserved 467, 475 in rabbits 588 homologous 467, 475 reI. of hist. in 588 reversed 467,473-475 in rooster 591 hyper immune 412 whole blood hist. in 588 in rabbits 470,471 symptoms 411, 412 in rats, action of AH 471-474 test, models for 411 role of histamine 478 Anaphylactoid reactions, by dextran 64 in rooster 477,478 Anaphylatoxin(s) in sheep 475 bronchoconstr. by 464 systemic 63 catecholamine reI. by 463 tachyphylaxis of (desensitization) 399 and complement activo 60 in vitro 399 depleted animals 412 in vivo, action of local anesthetics 418 hist. reI. by, action of AH 441 Andantol (see also Isothipendyl, D201) as hist. releasers 60 180,409,410,415 mast cell destruction by 459 steroisomers 198 non-histamine dependent action 452 Androgens 29 shock 452,468,478 LJ4-Androstene-2, 17-dione, hydroxylation Anaphylaxis (see also Anaphylactic shock) 551 405, 507, 575, 587 Androsterone, in NAS 377 acute cutaneous, action of AH 473,475, Anergen 591 479 Anesthetics 215 (and allergy), histamine theory 439,479 and histamine formation 120 AH in 439,446-450 Angiotensin 28, 576, 582, 583 assay local histamine release, g. pig. uterus II, genesis 583 399 in shock 579, 583 bronchoactive substances in 453 antagonists 27 and cAMP 443 Angiotensinogen 583 in cattle 476,477 Aniline hydroxylation, strain diff. 521 cellular mechanism 399 "Annex" part of (histamine) receptor 296,297, cutaneous, action of AH 443,466,467,473, 299,301,310,319,326,327,329,390,402 478 dipole-dipole forces 402 role of histamine 466,467 hydrophobic binding 296, 310, 311, 315, suppression by chlorphenesin and phen• 319,320,322,402 oxy-propanediols 535 ionic forces 402 discrim. between histamine and non-hista• van der Waals forces 402 mine dependent, by AH 439,442,444, Anoxia and histamine release 93-95 478 Antagonism, competitive 240,251,252, in dogs 469,470 259,265,296, 301, 303,314,323, 333ff. in fish (teleosts) 478 definition 364, 365 658 Subject Index

Antagonism, analogues and derivatives 186 double reciprocal plot 303, 309, 315, chemical structure 179,181,185,186 318,319,323,324,395 Anthisan (see also 2786RP, mepyramine, neo• Gaddum's equation 391 antergan, pyrilamine) 381, 383, 387, 389, hydrophobic interaction 362, 363 398,399,405,407,412,413,415,417,418, importance of steric factors 362 421-424 monomolecular 303 Anthraquinone 201 and non-competitive 333ff. Antiacetylcholine agents 424 test substances 335-339 Antiadrenergic drugs 381 functional 365 Antiallergic effects of AH 439ff. irreversible 315, 320 Antianaphylactic dose of AH, ratio with spe- metaffinoid 365 cific AH dose 451 non-competitive (metactoid) 333ff.,362, effects of AH 439ff. 364, 365 Antianaphylaxis (see Desensitization) hydrophobic interaction 362, 363 Antibody(ies) to angiotensin 583 monomolecular 303 cell bound 58 persistent (unsurmountable) 396 conformational changes 93 reversible 315, 320 formation, action of AH 442 Antagonist(s) to vasopressin 583 action, kinetics 295ff. Antibradykinin agents 303 Chamiere theory (effect) 295-312 properties of AH 443, 444 P-blockers 463, 474 Anticholinergic activity of AH 285,361, 363, competitive 299,316,326,327,333-336, 413,414,416,567 340,342,344 and complementarity of AH action affinity for metactoid receptor 345-348 413,415,424 drug moiety, critical and non-critical 352 of diphenhydramine 231 interaction with histamine receptor and electron density 414,416 342-345 agents (drugs) 280,296,352,381,390,413 mimetic moiety 344, 345, 353, 354 Anticonvulsant drugs 230 non-competitive spasmol. action 352 Antidromic vasodilation, effect of AH 421, optical isomerism and pharmacol actions 422 352 Antigastrin (see SC 15396) physico-chem. properties 347 Antigen(s) 50,60,67,68,79, 88, 164, 369, 399, structural formulas 342 400,406,411,412,441,453,455,456,458, structural relationship with agonist. 461,472 344,345 aerosol, action of AH 465, 466 dissociation constants, with receptor of azulene 466 391, 395 dose-response curves 465 full 326 and measurement of AH action 465 interaction with Hi receptors, quantit, shock, stages 465 studies 390 symptoms 465 irreversible 314 antibody complexes 93,475 metactoid (see Antogonists, non-competive) reaction and AH action 442, 455, 456, non-competitive (metactoid) 315, 333ff., 463 348,350,362 and ATP levels, mast cells 105 receptor complex 296-299, 301, 303, 312 and calcium 65 interaction 296 uncoupling effect 104 reversible 312 chrono- and inotropic effects 457,458,461 Antadryl (Mg 322) 409 degranulation mast cells by 79, 88 Antazoline (see also Antistin, Histostab) egg albumin, histamine release 106 180,283,306,308,381,383,387,407,413, lactate production 100 415,417,418,443,446-449,451,454,508, exposure to, and desensitization 60 510,590 role of calcium 60 action on CNS 564 histamine formation 113 pK. 177 histamine release by 57, 58,60,68,98 Antergan (see also 2339 RP, phenbenzamine) action of D20 63 3,178,183,186,381,383,387,389,398,399, of phosphatidyl serine 63 405,407,417,421,590,591 of cholinergic stimulus 64 Subject Index 659

Antigen(s) on isol.-striated muscle, anaphylactic and ATP content, mast cells 98 456 and CO2 production 100 on isol. uterus, anaphylactic 456 effect of phosphatidyl serine 100 role of cytoplasma membrane 456 and glucose metabolism 101 in local anaphylaxis 412 effect of phosphatidyl serine 101 in lung and trachea, in anaphylaxis and respiration of mast cells 97,98 453--455 role of calcium 60 in mesoappendix prep., rat. 122 specific 390 on passive cutaneous anaphylaxis 467 stimulation of glucose metabolism 58 qualitative and quantitative 424 Antihistamine(s), Antihistaminic(s) (see also of saIts 177 on skin vessels 420--423 Anti-H and Anti-H2 receptor antagonists 1 on triple response by histamirne (AH and Histamine Hl and Hrreceptor An• measurement) 421 tagonists) on urticarial manifestations 421 absorption 513 ff. on vascular permeability 420--423 distribution, metabolism and elimination activity(ies), competitive 300 513ff. correlation with antianaphylactic proper. g. pig, intest. tract 176, 177 439 s. c. route 589 definition 405--424 action on allergic histamine release 443 and electron density 414 on anaphylactic mast cell disruption 443 in vivo and in vitro 424 on anaphylactic reaction, coronaries 471 and adrenergic amines, in allergic asthma on anaphylaxis, diff. species 469--478 466 on antigen aerosols 465, 466 and adrenergic sensitization 462 bioassay 381 IT. adrenolytic (sympatholytic) effects 179 on bronchiolar smooth muscle 442 aerosols 442, 466 on cAMP 440 in allergy 389,421,507, 509 on catecholamine release in anaphylaxis fJ-aminoethyl side chains of 175, 176 444 in anaphylactic shock 401--412,441,445- on chrono- and inotropic histamine 450, 508, 591, 594 elTects 440, 441 in anaphylaxis 405,439,445--450 on CNS antagonism high doses hypnotics anti-Ach activity 177 562 antiallergic action (effects) 41O,439ff. behavioral studies 562 antianaphylactic action, and catecholamine avoidance mice 562 release 461--464 fighting in mice 562 antianaphylactic effects 439 IT. in humans 562 and antibody formation 442 clinical ex per. 563, 564 antibradykinin proper 443 elTect on hepatic micros. enzymes 563 ',anticholinergic action 420, 567 influence of chemical groups 563 complementary 413,415,424 interaction with other drugs 562 regression curves 416,419 in laboratory animals 561 and anticholinergic properties 285 mechanism 567-569 antiedematous activities 444 sedation by 567 antiinflammatoryelTects 505 IT. in allergic patients 563 antimotion sickness action 561,567 sleep duration 564 antiparkinson action 561 stimul. effects, high doses 563 anti prostaglandin action 505 therapeutic doses 562 antiserotonin proper. 443 tolerance to seda. action 563 assays, in vitro 391--404 on cutaneous anaphylaxis 466, 467 g. pig, ileum 179 on histaminase, in anaphylaxis 444 measurement alTinity parameters 391 on histamine-N-methyltransferase 444 and other smooth muscles 390-398 on histamine release by anaphylatoxin interaction with H2-receptors 390, 402- 443 404 in anaphylaxis 443 mammalian heart and atria 390,400,401 on isol. gut, in anaphylaxis 455,456 Schultz-Dale reaction 390, 399,400 on isol. organs 453-456 tracheal and bronchiolar muscles 398 660 Subject Index

Antihistamine(s), assays, in vivo, action on on histamine released endog. 441,442 skin vessels and vascular permeability local, anaphylaxis 399 390 uptake 443 on anaphylactic shock 390 on microcirculatory prep. 121, 122 on asthma, by histamine aerosol 390 an reactive hyperemia 421,422 atropine-like effects 390 elimination 513 ff. on guinea pig 179 epinephrine-blocking action 463 local anesthetic effects 390 equilibrium time 178 passive sensitization 411 factor affecting clinical observations 563 protection of lethal asthma (broncho• general structure 175, 17R spasm) 406-409 in heart anaphylaxis 457--461 protection against lethal histamine histamine aerosol quantal test, stages 406 effects 390, 40~1O and histamine formation 121, 122 protection sens. g. pigs to antigen and histamine metabolism 444 411--413 and histamine in pathophysiological pro- atropine-like actions 413--417, 462 cesses 386 measurement ofpA2 413 as histamine releasers 442 binding to plasma 177 hydrophobic properties 178 bioassays, for specificity and potency 390 influence in circulatory shock 590,591 blockade of histamine effects, CNS 568 in fighting mice 567 on nerve prep., frog 420 in Noble-Collip drum mortality 593 central effects 177 on survival, circ. shock 588,590-592 chemical structures 179 ff. in trauma mortality 592 chemical types 179ff. interaction with anesthesia 588 chemistry of anti-Hdreceptor) 175ff. with H1-receptors 402--404 chiral, stereoselectivity 234 with other CNS depressants 562 in circulatory shock 588-591 ionic properties 178 therapeutic aspects 577ff. ionization (percent) 176 classical (anti H1-receptor) 134,440 lipophilicity and action on CNS 285 action catecholamine release from local anesthetic action 417--420, 443, 444, suprarenals 401 462, 561, 567 action on chrono- and inotropic effects of and local anesthetics, regression curves 419 histamine 400 mechanism of action 295ff. clinical active doses 466 of interaction with H l-receptors 425 clinical and therapeutic applications membrane stabilization 443, 444 178,183,405,411 metabolic studies, cyanogen bromide reac• as CNS depressants 561 fT. tion 513-515 cocaine-like action 462 methyl orange reaction 513,514,516, as competitive antagonists 122,251,252 518-521, 523 compounds, structure 424 picric acid reaction 513-515 contractile effect on smooth muscle 122 radiolabeled compounds 513 cross tolerance with barbiturates 563 metabolism 513 fT. degree of activity 390 metabolites 177, 178,513 depolarizing actions 443 naturally occuring (NAS) in body tissues desensitization 442 369fT. differentiation of histamine and non-hista• mechanism of action 375, 376 mine components, in anaphylaxis 478 methods of assay 371 distribution 513ff. methods of extraction 370,371 by s. c. route 589 modification of amounts 372-375 double aromatic ring in 176 physical and chemical aspects 376, 377 drug-induced tolerance 549 role of 377,378 duration of action 177 effect of tissues, cells and biological EEG studies 562, 563 fluids 369 effect on acetylcholine actions, heart 416 eosinophils 369 on antidromic vasodilation 421,422 ketosteroid 369 on asthma 398 leukocyte extracts 369 on g. pig anaphylaxis 445--452 in eosinophil granules 369 Subject Index 661

Antihistamine(s), nomenclature 168 therapy, future outlook 594 in organ extracts, effect on acetylcholine toxicity 446-450 response 370 tricyclic derivatives 17 5 on bradykinin action 370 in urine after asthma 370 on histamine aerosol 370 use in sea sickness 411 on histamine response 370 vasoconstriction of arterioles 589 on serotonin response 370 vasoconstrictor effect of 122 pA2 measurement (g. pig ileum) 177, 178 Antihistaminergic (activities) 361, 363 pA2 values 382-385 Anti-H\-(Receptor) activity and physical con• partition ratio 280 stants 227-231 partition (water/lipids) 177 bond stability 229 pharmacological actions 381 ff. (J + constant 229 pKa values 176, 177 cationic head 227 potency 178 charge localization 229, 230 determination 406, 411 biological activity center (BAC) 229, methods 441 230 blue test 422,423 correlation with pKa 227 against lethal effect of histamine 441 dipole moments 230,231 and time of recovery 300 ionic interactions 277 potential value in shock 589, 594 ionization constants 227 potentiation of hexobarbital 562 membrane permeability 227 of pentobarbital 562 ratio protonated/free basic form 227 of var. general depressants 562 solubilities 227, 228 and precipitin titer 442 spectral data 228, 229 proprietary and intern. names 168 IR spectra 228 protection of anaphylactic shock 406-409 NMR studies 229 against lethal histamine effects 179 UV spectra 228 protonated features 178 surface properties 228 quantitative data 251 hydrophobic nature 228 quaternaryamines 177 interfacial tension 228 ratio antianaphylactic/specific AH doses nonspecific effects 228 451 Anti-H \-(Receptor) antagonists, synthetic receptor interactions, free energies 403,404 175ff. resistance to oxidation 176 Antiinflammatory drugs 477 and role histamine in inflammation 505 action on gastrointestinal bleeding 506 secondary cardiovasc. actions 589 assessment of role of histamine 508, 509 sedative effects 177, 561-566 effect on interactions with other mediators in shock therapy 589-591 in inflammation 506-508 "side effects" (non-specific) 439,442-444, response of tracheal muscle 509,510 459, 463 Antimetabolites 254 as spasmolytics 443,444 Antimuscarinic agents 413 species diff.-effectiv 589 and cholinomimetic activity 327 "specific" doses against histamine 439, Antimycin A 94, 104 453, 455 Antiosalbumin, mouse antibodies 474,475 spectrum of depressant effects 561 Antiprostaglandin activity of AH 505 spin-spin relax rate 177, 178 Antirheumatics 549 stereochemical features 178 Antisera and histamine release 60 stimul. action on CNS 561 Antiserotonin activity of AH 443, 444, 505 structure relationships 178 of cyproheptadine 506 synergism with released epinephrine 463 Antiserotonins 589 synthesis, methods 178, 179 Anti-SRS-A 472 synthetic 375,381,424,405 Antistin (see also antazoline, Histostab) 300, chemical structures 179 ff. 313,381,383,387,407,413,415,417,418, chemical types 179 ff. 443,446-449,451,454,508,510 formulas of common 382-385 Antrectomy 44 therapeutic action, CNS 561 ff. Aprobit (phenergan [promethazine)-2-chlo• aspects 576 ff. roethanol) 177,197,540 662 Subject Index

Aprobit excretion, mice, rats, g. pig 539 as degranulating agent 78 hydrophilic nature 539 and histamine release 58 metabolic studies 540 calcium uptake 65, 67 metabolism, autoradiographic e5S) studies turnover rate in mast cells 102 539, 540 utilization in histamine release 105 polar metabolites 540 Atria, isol. g. pig 10 sulfoxide 540 assay Hl-receptor and antagonist 401 Aprotinin (see also Trasylol) 472,475 hist. stimul. 252 Arachidonic acid 509 effect of burimamide 259 Arginine, AH effect 369, 381 of Hl-antagonists 263, 265 derivatives, as AH 300 of methylimidazolyl-propylthiourea esterase 167 258 vasopressin 28 of metiamide sulfoxide 282 Arrhenius plot 322 histamine uptake and metabolism 441 Arrythmias, in anaphylaxis 459, 460 stimulation by histamine-like compounds histamine-independent mechanism 460 252, 253 heart 9 Atropine 45, 50-53, 64, 112, 296, 299, 300, Arthritis, adjuvant 440 304,313,326,338,350,386,392,410. Arthus-like reaction 467 413,415,453,463,472,509,567 Arthus reaction (see also Anaphylaxis, local) and cAMP 62 412 effect on gastric secretion, diff. stirn. action of AH in 412,471 50-53 distinction from PCA 412 like activity 327,415,416 Ascaris lumbricoides 477 methods of determination 416 Ascites tumor (Dunn and Potter) 166, 167 compounds (anticholinergics) 300, 302, Ascorbic acid 398,549, 551 326,410,424 action on histamine excretion 115 198 Au (colloidal) 423 biosynthesis 552 Autacoids 477 formation and glucose metabolism 551, Autonomic drugs 398 552 nervous system 11 synergism with AH 472 mediators 381 urinary excretion, measurement, rats 549 Avomine (see also phenergan (promethazine) Aspirin 163, 507-510, 584 + 8 chlorotheophylline or theoclate) like drugs 507 183, 196 as PG-synthesis inhibitor 472 Aza-l,l-diaryl-3-aminopropenes, pAl values in platelet amine release and aggregation 238 68 Aza-diphenhydramine 225, 242 Asthma 142 Azatadine 200,443,450,474 action of NAS on 369, 370, 374, 378 Azepine 201 by aerosol, g. pig 478,479 Azide (sodium) 518 allergic (anaphylactic) 406,453,466 Azulene 466 action of AH and adrenergic amines 466 histamine in 406 BAME fbenzoyl-arginine methyl ester) 313 and allergy, action of AH 410 Bamipine (Soventol) 181,409,415 antigen aerosol 463 Barbital 5, 550, 552 controlled, stages of 465 morphine 418 by histamine 466 Barbiturate(s), comparison with AH central by histamine aerosol, protect. by AH effects 564 406, 410 cross tolerance with AH 563 human, AH in 479 effect on histamine metabolism 120 symptoms 442 on var. substances, in brain 120 ATP (adenosine triphosphate) 329 infl. by AH 564, 568 content in mast cells and histamine release lethality by chlorcyclizine 563 anaphylactic 101, 102, 104, 105 metabolism, liver microsomes, effect of by antigen and compound 48/80 104 chlorpromazine 550,551 changes 101-105 Barium, as agonist, trachea 509 by compound 48/80 101,104,105 chloride 28 Subject Index 663

Barium, spasm 454, 456 andHDA 44 sulfide 422 Binding energy 311,312 BAS 474 forces 311, 312 Basic drugs and histamine release 58 Bioassay of AH action 381 II. dyes as degranulating agents 78 Bioactivity, anesthetics 215 polypeptides, as degranulating agents 78 correl. with chemical structure 215,216 as main component granule protein 78 Biological activity center (BAC) of AH 229, Basophil(s) 110, 505 230 granules, expulsion 79 Biophase 328, 346 in mast cells 75 P-Blockade 462, 464, 479 dilI. tissues 88 Blood diseases and histamine metabolism and heparine content 88 excretion 142 preparation 75 flow 575,576, 578II. storage properties 82 increase 575 role of heparine 82, 83 regulation 582 of protein-heparin-complex 84, 85 pressure, systemic 386 of zinc 83, 84 vessels, in shock human, histamine release from 57 peripheral vasco failure 585 and immunoglobulins 60 small 585 Benadryl (see also diphenhydramine) 163, volume, in shock 580 182,300,301,313,314,381,382,387,389, Blueing responses 510 397,398,402,404,407,410,411,413,417- delayed 510 421,424,440,446-450,453,454,456,458, immediate 510 459,467-470,472,473,475-477,508,510 Blue toluidine dyes (for permeab. test) 422 14C-benzyl carbon, degradation products in BOL (148) 471-475,509 tissues and urine 518 Bond rotation 271,274,277 metabolic studies, g. pig 519 stabilities and anti-HI activity 229 concentration in g. pig, tissues 516-519 Bordetella pertussis vaccine 472 concentration in rat tissues 517-519 Bradykinin (see also Kinins) 24, 443, 454, degradation rat liver 518 460,472,475,476,506-508,583 distribution of free energies 397, 404 edema 508 early metabolic studies 513-516 formation, inhibition of 472 excretion, urine small animals 518 by proteolysis 583 3H, content in erythrocytes 519 induced-permeability and NAS action 370 levels in plasma, dogs, g. pigs 519 and NAS 375 rhesus monkeys 519 physiological action 583 metabolism, monkeys 520 potentiating factor 583 metabolic studies 516-523 in shock, pathogenesis of 583 methyl orange reaction 514,516, Bredereck procedure 286 518-520 Bromazine 222, 231 picric acid reaction 514 Bromdiphenylamine, action on CNS 564 metabolism, g. pig, rat, rabbit var. tissues Bromide 551 518 4-Bromo-3-hydroxy-benzyloxamine dihydro- metabolites, monkey, rabbit 520 gen phosphate (NSD-1055, brocrescine) pA 2, calculation 397,402 115-117 Benzyhydrol 520, 531 P-(p-Bromophenyl)-2-pyridylpropionic acid Benzhydryl bromide 182 glycine conjugate 535 piperazine(s) 531 Bromothen (see also brompyrilene) 180, 383, N-dealkylation 526, 527 387,407,415,447,448 Benzimidazol ring 181 p-Bromphenethylamines 362 Benzophenone 520, 531 Brompheniramine (DimetaneJ 532 3, 4-Benzpyrene, metabolism and action of 14C, blood levels and excretion, dogs 535 orphenadrine 552 demethylated derivatives 535 Benzyl chloride 181 half-life 535 magnesim chloride 186 maleate 182, 193,195,196 Betazole 334 metabolic studies 532-535 Bethanecol (cholinergic) 53 metabolism, dog, man 535 664 Subject Index

Brompheniramine N-oxide 535 heterocyclic analogues 278 Brompyrilene (see also Bromothen) 180,383, hydrogen bonded imidazol ribbons 272 387,407,415,447,448 hydrogen bonded species, structure 270, chemical structure 180 279 pK. 177 inhibition of gastric secretion 49, 259, 505 Bronchi, human 178 local anesthetic action 285 Bronchoactive substances, in anaphylaxis metabolism 280-283, 554 453 molecular structures, in crystal 272 Bronchoconstriction by anaphylatoxin 464 pA2 values 259, 260 by antihistamines 398 determination 393 Bronchoconstrictor agents 410,462,466 parti.tion octanol: water 262,279,280, 283, Bronchospasm 215,445,452 284 anaphylactic, action of AH 452-454,461, pharmacokinetics 280-283 469, 472 protein binding 553 by anaphylatoxin 452,461,462,471,472 35S, distribution pattern 554 by curare, action of AH 469 rotameric forms 269 effect of AH 398 specificity 54, 260 g. pig 179,369 synthesis 285, 286 by histamine 452, 453 tautomers 260,264,267,269,270,272 protection of AH 406, 410 infl. of side chain 260, 261 by methacholine, protection of AH 410 therapeutic potential 260 relieving agents 398 torsion angles for bond rotation 271 in vivo, effect of AH 452, 453 Burn(s) 440, 577, 587 Brontine (see also deptropine, detropine), injury 164, 166 citrate, anticholinergic action 201 shock, in fluence of AH 590, 593 antihistaminic action 201 Buscopan 398 com par. with diphenhydramine 201 Butallylonal 19 in g. pig anaphylactic shock 201 Buclizine (Softram) 185, 388,448 Calcium (ions) 401,424 Bufenadrine, tartrate 236 in antigen-antibody reactions 65 Burimamide (N -methyl-N'-[ 4-4(5)imidazolyl• in degranulation, mast cells 59 butyl] thiourea) 2, 3, 25, 41, 45, 46, 49, in histamine release 64--66 51,53,54,118,134,163,253,262,264,279, anaphylactic 65 283-285,440,444,454,458,460,463,470, by antigen 58 472,477,552,590,592,593 gates, cell membrane 65, 66, 68 absorption and distribution 280,281 membrane dislocation 68 action on CNS 285 by sev. agents 58 action on HDA 45 ultimate mediator 65, 68 anticholinergic activity 285 interaction with cromoglycate 65 biologically "active" from 271 with dibutyryl cAMP 65 chemical constitution 267-274 with phosphatidyl serine 62 estimation 281 transport, inhibition in smooth muscle 3 compo methylene and thioether linkages cAMP (see Cyclic AMP) 262, 264 Capillary constriction 505 as competitive antagonist 259, 260 dilation 505 crystal structure 271 permeability, in mice anaphylaxis 475 development 256-260 Carbachol (see Carbamylcholine) dissociation constant, apparent 259-261, Carbamylcholine (carbachol) 260 263 action on antigen induced hist. reI. 64 distrubution, rat body 553 and cAMP 62 effect od cAMP on 46 effect in tissue and mast cells 62 equilibrium dialysis 553 Carbinoxamine (see also Clistin) 184,234 as Hz-receptor antagonist 49,401 stereoconfiguration 184, 185 3H 260 Carbon dioxide (see also CO2) 582 and 35S, metabolism, rats 552, 553 monoxide 518 half-life, uptake into erythrocytes, sev. spe• tetrachloride 551 cies 553 poisoning 228 Subject Index 665

Carcinogenic hydrocarbons and ascorbic ac. Chemical mediators of hormonal neurotrans• metabolism 551 mission 581 Carcinoid, argyrophilic gastric 110 of shock 581 Carcinoidosis 143 of vasotropic effects 581 Carcinoma, breast 168 Chemotactic factor 89 Cardiac functions, parameters and hist. action in mast cells 78 7ff. Chiral center of c1emastine 234, 237 Cardiovascular action of histamine (see Hista• diphenhydramine 234, 235, 239 mine, actions) sev. AH 235, 236 dynamics 582 Chloralose 4,5, 15-18 measurement 577 Chloralose-pentobarbital 5, 8 physiology 23 Chlorcyclizine (Diparalene, Histantin, Perazyl, Carrageenan 468, 507 Trihistan) 185,384,388,398,408,447, edema, effect of AH 507 450,508,510,521,564,565 mediators 507 action on CNS, hypnotic effect 564 phases 507 potent. of barbiturates 563 inflammation 507 on hexobarbital metabolism (liver micro• Catalytic hydrogenation 194, somes) 529, 550 Catecholamine(s) 27, 153,328, 381, 390, 398, of liver N-demethylating system, rat, 400,401,457,462,466,575,582 rabbit. on 528 {I-receptors 260 on 3-methyl-MAB metabolism 550 release by anaphylactoxin 463 pentobarbital metabolism (liver microso• in anaphylaxis, action of AH 444 mes) 550 antianaphylactic action of AH, in acute on zoxazolamine metabolism (liver micro- shock 461-464 somes) 529, 550 "endogenous" 462 t-butyl analog. metabolism 529 in heart anaphylaxis 461 chronic administration, rat 528, 529 by histamine 400,401,463 concentration, rat tissues 528 in protracted anaphylactic shock, action N -demethylation, rat, dogs, humans 527, 528 of AH 464 rat, sex diff. 528 in rabbit anaphylaxis 471 HCl, N-demethylation, dogs 527,528 role in anaphylatoxin action 464 diet, rat, and pentobarbital metabolism secretion 584 549 sensitivity to 580 metabolic studies 527, 528 sensitization by AH 463 N -oxidation 539 and sympathomimetics 579, 582 inhibition, accumulation, imipramine, lung Cation(s), exchange, as storage and release 547 mechanism, hist. 87-89 as liver microsome enzyme inducer 550 extracellular, in hist. reI. 93 metabolism 526-531, 538 from granules 58 dog, rat 529, 530 flux, in hist. retention by granules 82 action of chronic administration of and histamine reI. from granules 82 chlorcyclizine on 551 Cell disruption, and hist. reI. from mast cells metabolites 178 58 N-oxide, and microsomal system 527 membrane, permeability in hist. reI. 59, 68 pK" 177 Charge localization, and anti-H 1 activity and phenylbutazone metabolism 529 229 phenylbutazone test 548,549,551 transfer, at receptor site 302 stirn. of steroid hydroxylation, liver micro• Charniere effect 297-299, 302, 315, 320, 324, somes 551 328, 397 urinary excretion of ascorbic ac. 551 applications 312-325 teratogenic properties 527 demonstration 298 tissue protein affinity constant 529 microphysical model 309-312 and TPNH-oxidase activity, liver microso• thermodynamic basis 297, 298 mes 551 theory 295-312,319,322,323,326,327, ~hloretone 552 402, 403 Chlorfenoxamine 220,231 666 Subject Index

Chlorhetramine, metabolic studies 520,521 3H, maleate, metabolism and pharmaco- (p-Chlor-IX-methyl)-diphenhydramine kinetics, man 533 410, 415 plasma, half-life 533 Chloroacetonitrile 181 polar metabolites 533, 534 p-Chlorobenzaldehyde 184 protein binding 533 p-Chlorobenzhydrol 527, 531 hydrogen maleate 236 glucuronide 531 inactivivation by liver enzymes, rat, infl. age N -(p-Chlorobenzhydryl)-ethylenediamine 534 529,-530 maleate, studies in vivo, rat, infl. age 534 p-Chlorobenzophenone 527 studies with liver slices, rat, infl. age 534 Chloroform 5 metabolic studies 532-535 Chloroform-ether 5 computer programs 533 p-Chloro-p-methoxybenzhydral 527 metabolism, studies with liver microsomes p-Chlorophenol 536, 537 534 N -(y-(2-Chloro-phenothiazinyl-l0) propyl) pA2 206 ethylenediamine 538 pharmacol. studies optical isomers 234 p-Chlorophenoxyacetic acid 536, 537 pKa 177 p-Chlorophenoxylactic acid 536, 537 therapeutic and toxic doses, infl. age 534 Chloropyramin (see also chloropyribenzamine; tissue distribution 534, 535 Synopen) 218, 342,447 urinary excretion 532 Chlorothen (see also chlorpyrilene, Tagathen), infl. flow rate 532 383,387,408,415,420,447,448 infl. pH 532 action on CNS 564 o-Chlorpheniramine (see also o-Chlortrime• 8-Chloro-theophylline 183 ton, Polaramine) 338, 348, 384, 404, 409, Chlorphenergan 300, 313 420 Chlorphenesin 536, 537 L-Chlorpheniramine(seealso L-Chlortrimeton) 14C, metabolites, rat, dog 536, 537 348,384,388,404 metabolic studies 535-537 EEG changes by 569 tissue distribution, rat 537 oL-Chlorphenirarnine 226 Chlorphenesin carbamate 536 EEG changes by 569 acidic metabolites 536, 537 Chlorpromazine (see also Amplictil, Thora• O-glucuronide 536, 537 zine, Largactil, 4560 RP) 196, 197, 300, 3H, half-life 537 313,388,467,470,475,521,538,551, metabolic fate, dogs 537 589, 590 metabolism, dog 536 N-demethylation 521, 539 ratio of metabolites, dog rat 537 hydroxylation, C-3 and C-7, ring 539 metabolic studies 535-537 as liver microsome enzyme inducer 550 oxidation, rat 536 metabolic alterations, phenothiazine ring O-sulfate 537 539 Chlorpheniramine (see also Chlortrimeton; metabolic studies 538-543 Piriton, Polaronil, Teldrin) 22,25, 172, N-oxidation 539 199,381,388,408,418,440,446-450,456, oxidative deamination, rat liver microsomes 459,460,468,473-475,507,508,510,532, .539 590, 592 sulfoxidation 539 action on CNS Chlorprophenpyridamine 451 antagonism with ethanol 562 maleate 410, 415 effect on EEG 565 Chlorpyribenzamine (see also Chloropyra• hypnotic effect 564, 565 mine, Synopen) 381,383,408 sedative EEG by 562 Chlorpyrilene (see also Chlorothen, Tagathen) sedative effect 565 180,383,387,408,415,420 14C and 3H, metabolism, rat, dog 533, 534 chemical structure 180 metabolites 533 pKa 177 comparative metabolism, man and dog Chlortrimeton (see also chlorpheniramine, 533 Piriton, Polaronil, Teldrin) 193, 195, 196, N -dealkylation, dog, rat 534 381,388,408,418,440,446-450,456, N-demethylation 532 459,468,473-475,507,508,510 compo studies 534 D-Chlortrimeton (see also o-Chlorphenir• liver, sev. species 521, 522 amine), Polaramine) 384, 404, 409, 422 Subject Index 667

L-Chlortrimeton (see also L-Chlorphenir• Cinnamylpiperazine 531 amine) 384,404 Cinnarazine (see also cinnarizine; Stugeron) Chlorzoxazone 551 185 Cholecystokinin 582 Cinnarizine (cinnarazine, Stugeron) 185 446 448 ' , as HDA stimulator 44 Cholera toxin, inhibition of histamine release N -dealkylation 531 by 61 14c, metabolism and excretion rat 531 N-oxidation 531 ' Cholinergic stimulation, as enhancer of his!. in treatment of allergy and vertigo 531 reI. 62, 64 Circulatory shock 575ff. Cholinergic ~ystem, rat intestine, competitive antagonIsts 334,337,339-341,349,350, adrenergic blockers 582 353,355,360,362,363 angiotensin in 583 affinity values 341,350,351,360 antihistamines in 576 pA2/pD~ ratios 345-348 blood flow in 581 pA2 values 336,337,339,351,353-360,362 cardiac output 577 pA2 values and lipophilicity 360 cardiovascular disfunction 581 pD2 values 336, 337, 339 measurement 577 pDi values 336, 337, 339, 350, 351, 353 catecholamines in 584 355-360 ' in cats 581 and lipophilicity 361,362 decompens. phase 581 Cholinomimetic and antimuscarinic activity endothelial cells in 581 327 factors in, anaphylaxic 577 Cholinomimetics 295,316,352 burns 577 Chondroitin sulfate 554 cardiac damage 577 Chromaffin cells 400 hemorrhage 577 granules 400 sepsis 577 trauma 577 Chromophore (arom. double bond) 187 vascular tone 578 Chronotropic action 8-12 Chrono- and inotropic effects, by diff. stirn., hemodynamics 578 hydraulic type 578 mechanism of 458, 459 hypotension in 576 non-histamine factor 459 hypovolemic patient 578 Chymotrypsin 88 in test. circulation in 581 in mast cells 78 ischemia and trauma 581 Cimetidine (W-cyano-N-methyl-N' ischemic state 581 [2-(5-methylimidazol-4-yl) kidney morphology 581 methylthioethylJ guanidine) 266,267, liver circulation 581 279,283,284,505 microvasculature 578, 581 action on CNS 285 pathogenesis 575, 577, 582 chemical constitution 274-277 mediators 575 as competitive antagonist 265 pathophysiology 575, 579 development 265-267 physical stage of organs 581 dissociation constant, apparent 265 refractory phase 581 effect on gastric secretion 264, 265 resp. measurement 577 Ka values 274 role of microvesse1s 577 local anesthetic action 285 of polypeptides 583 NMR spectroscopic studies 277 of serotonin 583 pA2 265 partition coefficient (octanol: water) 266, stress and 581 267,279,280,283,284 syndrome 575ff. physicochemical prop. 266, 267 therapeutical aspects 577, 578 stable configuration 277 therapy by AH 590, 591 staggered configuration 276 toxic elements 581 sulphoxide 283 vascular events 578 synthesis 285, 286 vasoactive mediators 581 ff. tautomers 267 vasopressin in 583 torsion angles for bond rotations 274 Clark's constant 391,394 Cinnamaldehyde 531 Clark's occupation theory 328 668 Subject Index

Clem as tine (N-methyl-2-[2 1-(2-methyl-p• experimental 365 chloro-benz-hydryloxy] ethyl• Configurational changes 295 pyrrolidine) 234,237 Conjugated histamine 136-139,141 actions CNS 569 Coronary constriction, anaphylactic 459,460 Clemizole (see also Allercur) penicillin 471 mediators 460 synthesis 181 flow 13 Clistin (see also carbinoxamine) 184 in anaphylaxis 459,460 stereoconfiguration 184, 185 Corticoids 119 1-(4-CI-phenyl)-1-(2-pyridyl)-3-N• role in protracted anaphylactic shock 464 pyrrolidinoprop-1-ene 385 Corticosteroid(s) 462,478 Clospirazine 541 therapy, in allergy 509 3H, concentration, rat organs 541 Corticosterone 377 metabolic studies, rat 540, 541 Cortisol 118, 119 metabolites 541 Cortisone 110, 133, 377,475 protein binding of serum 541 Covalent bonds, at receptor site 302, 320, 322 CNS-depressant effects of AH 285 Creosote 371 CO2, production from glucose, in hist. reI. 101 Cromoglycate (dis odium, sodium) 163, 466, stimulation, and hist. reI. 99, 100 472,473,476,509 14C02 112 in allergic asthma 64 measurement 110 inhibition of anaphylactoid reactions 64 Cocaine 300,313,462,463 of cAMP-phosphodiesterase 64 Colchicine 473 of histamine release 64 inhibition of hist. reI. 59, 63 of mast cell degranulation 64 of platelet aggreg. 68 interaction with Ca ionophore 65 Collagen, in platelet amine reI. and aggreg. 68 CrP (creatine phosphate) 329 Common mediator hypothesis (theory) of Cu-chlorophylline 464 gastric secretion 41,43,46,47,50,51,53,54 Curare 469 Competitive antagonism (see Antagonism, Cutaneous anaphylaxis (see Anaphylaxis, competitive) cutaneous) Competitive antagonists (see Antagonists, Cyanide (sodium) 94,95, 518 competitive) Cyanogen bromide reaction, for AH metabolic Competitive and non-competitive antagonism studies 513, 514 (see Antagonism, competitive and non• Cyanoguanidine(s) (dicyandiamide) 274 competitive) bond length and angle 277 Complement, activation, in hist. reI. 60 bond rotation 277 components (3rd and 5th), cleavage products conformational isomerism 277 as histamine releasers 60 dipolar structure 274 depleted animals 412 N > M'-disubstituted-N" - 274 and histamine release 60 prototropic equilibria 274 Complementarity of receptor 346-348, 350 Cyanoguanidine(s), cont'd. Compound 48/80,76,163, 166, 167,378,454, staggered configuration 276 455,459,469,472-475,506,508,510 free energy of activation 277 effect on acid secretion and hist. reI. 48 geometries 277 as degranulating agent 78, 79, 88 interconversion of isomers 277 effect on normal mast cells 81 physiocochemical prop. 266, 267, 274 histamine release by 57, 58, 62-64, 93, 98, pKa 271 106 prototropic equilibria 275 ATP content of mast cells 101,103-105 similarity with thioureas 277 energy metabolism 105 tautomers 274 glucose metabolism 99, 101 Cyanoguanidinium ion 274 inhibition 64, 94, 95 Cyclic AMP (cAMP) 30 lactate production in anoxia 100 action of adenine on 62 oxygen consumption 98 of antihistamines on 440 Concanavalin A, and hist. release by of atropine on 62 phosphat idyl serine 63 of carbamycholine on 62 Concentration-effect curves 334 of compound 48/80 on 62 cumulative 334 of diazoxide on 62 Subject Index 669

Cyclic AMP excretion in milk 545 of epinephrine on 61,62 metabolic studies 543-546 of histamine on 401 metabolism, species-dependent toxicity role of Ca 401 545 on histamine release 64 metabolites, sev. species 543, 544 of propranolol on 62 minor 544 of prostaglandin E 1 on 62 N-oxide 544 of theopylline on 62 N -oxide conjugate, man 544 as endogenous inhibitor of hist. reI. 64 placental transfer 545 in anaphylaxis 443 radiolabeled, metabolism, human 544 effect of H2-receptor antagonist on 401 ratio tissue: plasma distr. rat, dog 544, of histamine on, in heart 458 545 in histamine release 61,68 Cysteamine 286 intracellular conc. 64 Cystein 518 levels in tissues 67 modulation of hist. reI. 61, 64, 65 DCI 400 role of Ca 61, 68 DCNB-dermatitis 467 phosphodiesterase 466 N-Dealkylation, cinnarizine 531 inhib. by cromoglycate 64 . Decaborane 116, 117 reversal of bur imam ide inhib. gastric secr. Decapryn (see also doxylamine) 184, 382, 387, 46 389,408,413,415,420,446,447,463,474 role in histamine release 105 in blood, rabbit 515 Cyclic 8-bromoguanosine 3', 5' MP, action on rat 515 hist. reI. 64 distribution in rat tissues 515 Cyclic GMP (Cyclic guanosine-3', elimination urine, dog 515 5'-monophosphate, cGMP) metabolism, early studies 515 interaction with cholinergic stimuli 64 Decarboxylases, specific and non-specific 115 as modulator of histamine secretion 62 Degranulating agents 75,78, 87 Cyclic nucleotides and histamine release 61, Degranulation, mast cells 62,68 by antigen 79, 88 Cyclizine (Tavegyl) 388,447, 527, 564, 565 electron microscopy 79, 96 action on CNS 564 and histamine release 58, 59, 87-89,96 and analogues, chern. structure 185 light microscopy 96 anti-emetic act. 185 morphologic changes 79 chronic administration, rat 528, 529 partial 75 clinical effects 185 process, non-cytotoxic 79 concentration, rat tissues 528 Dehydroepiandrosterone 377 HCl, metabolic studies, rat, dog 527, 528 N-Demethylation, aminopyrine 521 metabolic studies 526-531 amitriptyline 545, 547 metabolism, dog 529 antihistamines 521, 522 pA2 185 in antihistamine metabolism 521 pKa 177 brompheniramine 535 tissue protein affinity constant 529 chlorcyclizine, sev. species 527, 528 Cycloheximide 118, 119 chlorpheniramine 532, 534 antiinflammatory activity 118 chlorpromazine 539 Cyproheptadine (Periactin) 198, 199, 300, liver microsomal system 539 338, 350, 385, 443, 447, 450, 467, 468, cyclizine, dog, rat 527,528 473-476, 506-508, 510, 543 cyproheptadine 544 antibradykinin action 199 dimetotiazine 541 anticholinergic action 199 diphenhydramine 521, 548 antihistamine action 199 strain diff. 521 antiserotonin action 199 hepzidine 548 aza-analogs 200 imipramine 547 14C, concentration plasma, tissues, dog 544 orphenandrime 521, 522, 548 metabolism, rat, dog, cat 544 protriptyline, dog 545 clinical use 543 tripelennamine 526 derivatives 199 Demethylcyproheptadine 10, ll-epoxide 543 670 Subject Index

Demethyldimetotiazine 541 SAR 225, 237-239 S-oxide 541 1,I-Diaryl-3-aminopropanes 216,225,226, 2-DeoxY-(D)-glucose, action on hist. reI. 66 242 anaphylactic 103, 104 pA2 values 225, 226 by compound 48/80 104 SAR 225, 226 as inhibitor of glycolysis 94 1,I-Diaryl-l-aminopropenes 234 as stimulus for HDA 43,44 Hansch approach for SAR studies 233 and stimulation of gastric ac. secretion hydrophobic bonding 234 49, 52 1,I-Diaryl-3-aminoprop(-I-)enes 189fT., Depolarization of cell by histamine releasers 216, 242 59 E and Z forms 190, 191 Deptropine (see also detropine, Brontine) pA2 values 237-239 548 pharmacological studies 191 N_14CH3 549 SAR 225 N-demethylation 548 stereoisomerism 189, 190 inhibition of demethylating enzymes 548 synthesis 189 of N -demethylation of diphenhydramine 1,I-Diaryl-3-N-dimethylaminopropenes 548, 549 384 Dermatophytes 509 pA2 values 240 Desensitization (antianaphylaxis), action of QSAR 240 AH 442 1,I-Diaryl-3-N-pyrrolidinopropenes of phosphat idyl serine 66 241, 385 control of hist. reI. 66 Diathiaden 202 and histamine reI. 61,66,67 Diatrin (see also methaphenilene) 381,383, mechanism 66, 67 408,415 role of Ca 66, 67 Diazoxide, action on cAMP 62 N -Desmethyl-chlorpheniramine 532-534 Dibenamine 323, 324, 390, 397, 464, 578 N-Desmethyldiphenhydramine 520 5-H-Dibenzo [b,j] azepine derivatives 201 N -Desmonomethyl-chloropheniramine 5-H-Dibenzo [a,d] cycloheptene 198 532-534 Dibenzyline (phenoxybenzamine) 323, 390, Desoxybenzoin 186 397, 578 Detergents and hist. reI. from mast cells 58 as competitive antagonist 397 Detropine (see also deptropine, Brontine) 200 Diborane 205 Deuterium oxide (D20) 182 Dibucaine 418, 419 as enhancer of hist. reI. 62, 63 Dibutoline 413, 415 as stabilizer of microtubules 63 Dibutyryl cyclic AMP 163 Deuterochloroform 182 in hist. reI. 64~6 Dexamethasone 464,472, 509 N-Didemethylation, of amitriptyline 545 Dextran, anaphylactoid reactions by 64 Didemethyldimetotiazine 541 as degranulating agent 78 N,N-Didesmethyldiphenhydramine 520 histamine release by 58, 98 Diencephalic lesions 120 action of sev. agents 63, 101 Diethazine (2987 RP) 389, 453 and desensitization 66 2-Diethylaminoethanol 519 and glucose metabolism 58, 99, 101 4-(Diethylaminopropyl-amino)-7 -chloro- lactate production in anoxia 100 quinoline 521 DFP (see diisopropylfluorophosphate) Diethylcarbamazine 473, 476 Diamine formation, intracellular 111 citrate 509 Diamine oxidase (histaminase) 132,169 1O,II-Dihydro-5-H-dibenzo [a, d] cyclohep• after heparin 134 tene 201 in human tissues 139 1O,1l-Dihydro-5-H-dibenzo [a,d] cyclo• inhibition 112, 114 hepten-5-o1 548 mucosal 45 1O,11-Dihydro-1O,II-epoxy-5H-dibenzo physiological role 132 [a, d] cycloheptene 544 1,2-Diaryl-4-aminobutenes 185fT., 191,216, Dihidroergotamine 470 225, 241 9,1O-Dihydro-ethanoanthracene(s) 204 pA2 values 237, 238 1O,11-Dihydroxycyproheptadine (cis and QSAR 240 trails) 544 Subject Index 671

10,II-Dihydroxydesmethylcyproheptadine comparison with local anesthetic effects (cis and trans) 544 567 Diisopromine 226 with secobarbital 564, 566 Diisopropylfluorophosphate (DFP) 163, 167 as competitive antagonist 299,301,303, as inhibitor of hist. reI. 59 306, 307 Dimenhydrinate (see also Dramamine), action concentration g. pig tissues 516-519 on eNS 564, 566 degradation, rat 518, 519 antimotion sickness action 567 N-demethylation 548 Dimethindene (1-[I-(2-pyridyl-ethyl)-2-(2- inhibition by deptropine 548, 549 dimethylaminoethylJ indene) 202, 338, liver microsomes, rat 521 446 liver, various species 521, 522 synthesis and isomers 202 liver, strain and sex diff. 521,522 Dimethylamine 186 derivatives 179, 382,413,414 Dimethylaminoethanol 182 action on eNS 562 Dimethylaminoethyl chloride 180 aryl substituted 177 Dimethylaniline-N-oxide, pig liver micro- biological activities 419 somes 521 methohalides 177 N,N'-Dimethyl-N"-cyanoguanidine(s), p. methoxy, chloro and bromo subst. configuration 275, 276 183 crystal structure 276 4-methyl subst. 178 isomerization 274 a-methyl subst. 183 free energy activation 275 2-pyridil subst. 183 S,N -Dimethyl-N' -cyanothiourea 286 dipole moments 230,231 N",N'-Dimethylhistamine 253 distribution of free energies 397, 404 Dimetotiazine 541 early metabolic studies 513-516 metabolic fate, dog, man 541 effect on awakening, children 569 metabolites (dog, man) 541,542 on biogenic amines 567 antihistamine activity of 541 on EEG 563, 566 toxicity of 541 on zoxazolamine 551 S-oxide 541 excretion, urine small animals 518 Diparalene (see also chlorcyclizine; Histantin, 3H, content in erythrocytes 519 Perazyl, Trihistan) 384, 388, 398,408 3H, levels in plasma, sev. species 519 Diparcol 415 3H, metabolism, monkeys 520 Diphenylhydantoin 374 Hansch approach SAR studies 232, 233 Diphenhydramine(s) (see also Benadryl; optically active isomers 239, 240 2-dimethyl-aminoethylbenzhydryl ether) Hel, studies in vitro, rat liver 534 25, 163, 204, 216, 217, 219, 220, 223, 224, in vivo, rat 534 228,229,231,235,242,243,251,252, hydrophobic fragmental constant 240, 244 297-301,312-316,320,329,362,381, 382, hypnotic effect 569 387,389,397,398,402,404,407,410,411, induction of sleep 562 413,417-421,424,440,446-450,453,454, inhibition amphetamine uptake 547 456,458,459,467-470,472,473,475-477, catecholamine uptake 567 508,510,547,589-592 central effects of his!. 568 action on eNS 562, 564, 566, 567 imipramine uptake 547 antiacetycholine action 183,419 local anesthetic effect 419, 567 anticholinergic action 231, 567 metabolic studies 516-523 antihistaminic action 231,419 methyl orange method 514,516,518-520 antimotion sickness action 567 picric acid reaction 514 behavioral studies 562 metabolism, action of chronic administra• bioassay, g. pig ileum 179, 182 tion of diphenhydramine 551 biological activity pattern 230, 231 and action of orphenadrine 552 bond stability 229 various species and tissues 518, 552 14c, degradation products in tissues and metabolites, rabbit, monkeys 520 urine 518 N-oxide 520-522 benzylcarbon, metabolic studies, g. pig pAl values 183,220-225,235,236,239, 519 244, 397, 402 chiral center 234. 235. 239 optical antipodes 219 672 Subject Index

Diphenhydramine(s) lines, AH in g. pig ileum 391 racemates 239 Double isotope assay, for histamine 154-164 partition rate 280 assay blanks 162, 163 phenylbutazone test for 549-551 calculation 159, 160 pK. 177 conditions for 158 potentiation by ethanol 562 diff. procedures 165 by hypnotics 562 {PH-histamine, as int. stand. 154-161 primary amines 222 incubation procedure 157 prolonged depression 562 interference 163, 164 quaternaryamines 224 microassay 164 reduction movements, mice 562 precision 162, 163 SAR 220-225, 243 specificity 162 secondary amines 222 standard curves 159 sedative effects 182, 562, 564, 566 storage and prepar., samples 156,157 sleep like EEG 562 Double reciprocal plot(s) 303, 304, 315, 318, spectral data 229 319,323,324,395 stereoselectivity 234, 244 Clark's treatment 395 stimul. urinary excretion ascorbic ac. 551 for determination of pA2 394-396 synthesis 182 intercept of dose-response lines 394 tertiary amines 222, 224 ratio of slopes 394-396 tissue distribution, rat 534, 535 Doxepin 546 UV spectra 228, 229 14C, metabolism, rat, dog 546 1,I-Diphenylaminopropenes 225, 226 clinical use 546 Diphenylcarbinols, UV spectra 228, 229 metabolic studies 546, 547 1,5-Diphenyl-3-dimethylaminopyrrolidine(s) metabolites, minor 547 240 urinary, rat, dog 546,547 as cyclic forms of phenbenzamine 204 N-oxide 547 diastereo isomers 204, 206 tissue levels 546 Hnmr spectral analysis 206 Doxylamine (see also Decapryn) 382, 387, indol derivatives 206 389,408,413,415,420,446,447,463,474 stereoisomers 205, 206 action on CNS 564, 566 synthesis 206 in blood, rabbit, rat 515 Diphenylmethoxyacetic acid 520 com pet. with secobarbital 564, 566, 587 glutamate conjugate 520 distribution rat tissues 515 Diphenylpyraline (Histryl) 183, 547, 564 elimination, urine, dog 515 1,I-Diphenyl-3-pyrrolidino-prop-l-ene 191 metabolism, early studies 515 Dipole-dipole forces 402 stimul. effect 566 moments and anti-HI activity 230 synthesis 184 Dissociation constants of H2-receptor anta• Dramamine (see also dimenhydrinate) 183, gonists 256, 257, 260, 263 197,417 apparent, burimamide 259,260,261, action on CNS 564, 566 263 Dromotropic action 8-12 cimetidine 265 Drug(s), biphasic response on liver microsomal imidazol cations 263, 264 enzymes 550 imidazole ring 263, 264 drug interaction 549 metiamide 265 and enzyme induction 549-552 overall, antagonist with receptor 395 metabolism, pharmacological parameters Distribution of AH (see Antihistamine(s), 513 distribution) 513 ff. species differences 520, 522 Divalent cations, requirement for hist. reI. 58 metabolizing enzymes, action of drugs 549 DNA synthesis, by gastrin 45 effect of chronic drug administration Dopa decarboxylase 112 549 Dopamine 475, 476 and glucuronic ac. pathway 552 in mast cells 75 influence of age 535 turnover, in brain 120 parameters 333 Dose-response, AH in g. pig ileum 391 receptor complex (see also Antagonist• curves, H2 receptor antagonists 259,260 receptor complex) 296, 328 Subject Index 673

Drug(s), azo bond cleavage 549 interaction 254, 256 biphasic response of drugs on 550 and gastric secretion 47 N -dealkylation 549 hydrophobic 254 deamination 549 transference 346, 348, 350 ether cleavage 549 stereospecificity 348 glucuronide formation 549 "unspecific" changes 346 nitro group reduction 549 Dummy parameter 233,241-244 sulfoxide formation 549 shock producing, lysosomal hydrolases E(entgegen)= cis 186, 187 575 Edema, histamine release in 167 proteases 575 pulmonary, in cattle anaphylaxis 476 Enzymatic isotopic method for hist. determi• rat foot (paw), action of NAS 378 nation 120 by bradykinin 507, 508 Enzymatic reactions and hist. secretion 59 by carregeenan 507 Eosinophils 369, 375, 377, 378 by histamine 446,505-507 cytochemistry of granules 369 by serotonin 505, 506 Ephedrine 466 by sev. subst., mediators of 507, 508 Epinephrine (see also Adrenaline) 28, 122 by sodium urate 508 163,444,453,456,462-464,470,472,505, by yeast 508 582 EEG studies, changes by AH 569 and antigen-induced hist. reI. 61,62 comparison of AH with barbiturates 562 efTect of combined administration with convulsion by AH 563 pyrilamine in HLP 462 dissociation from behavior 563, 567 efTect, heart 458 efTect of AH 562ff. 10,11-Epoxidesmethylcyproheptadine 544 sedative pattern by AH 562, 563 Equilibrium agonist vs. antagonist 301,329 stirn. pattern by AH 563 constants 302, 329 "Efficacy" 278 dyalisis methods 178 Egg-albumin (ovoalbumin) 411,412,472, Ergotamine 381, 400 509, 510 Erythema, by histamine, in skin 421 Electron-micrograph(s), degranul., mast cells by UV 421 77-80 Erythrocytes, 3H -diphenhydramine content Electron-microscopic autoradiograph, in de• 519 granulation studies 80 ({3) Estradiol 119 changes, in degranul, mast cells 79 in NAS 377 Electrostatic-dipole bond 402-404 Estrogen(s) 29, 138, 141, 582 Elimination of antihistamines (see Antihista- Ethanol 562 mines, elimination) 513fT. as inhibitor of hist. reI. 105,562 Embden-Meyerhof pathway 99 Ethanolamine(s) 227, 588 Embramine 220 Ether-chloralose 16 Emphysema, lung 452 chloroform 16, 18 reinforcing factor 461 urethane 8 Enantiomorphs, activity of 404 Ethopromazine, action on eNS 564 pA2 values 385, 404 3-Ethylamino-l-phenylpyrrolidine(s) Endothelial cells 26 204, 205 "gaps" 27 Ethylenediamine(s) 176, 179fT., 216-219, 225, Endotoxin(s) 111, 114, 118, 164, 166,440 227,242,532,537,538,563-565,588 and HDA 113, 114 as metabolites of piperazine ring cont. as histamine releasers 60 drugs 530 Enterochromaffin cells 112, 117 pA2 values 216-218 histamine in 115 SAR 216-218 like cells 118 Exocytosis, mast cell granules 75,89,93, 105, Enzyme(s) induction and drug metabolism 106 548-552 changes 79 liver microsomes, alkyl chain oxidation histamine reI. in 58, 68, 89 549 sequential 82, 88 aromatic hydroxylation 549 serotonin reI. 89 674 Subject Index

883 F (Prosympal) 386, 405 Gastric (acid) secretion, action of benadryl on 929 F (thymoxyethyldiethylamine) 179, 413 382,386,387,389,399,405,409,417,445, basal 44 446,450,456,590 histamine and 41 ff. 933 F (2-(I-piperidinomethyl)-1,4-benzo- common mediator hypothesis 41,43,46, xane) 179,300,313 47,50,51,53,54 936 F 382 by diff. stimuli, action of AH 416 1167 F 382 effect of histamine 252 1509 F 407 of histamine-like compounds 252, 1571 F 179,383,387,399,405,407,449, 253, 260 450, 590 electricalli stirn., inhib. by burimamide 1655 F 382,405,406 259 1709 F 405, 407 and HD inhibition 116 1971 F 445 histamine in 109 Fakuda's factor 575 formation in 110 Fenethazine, N-demethylation, liver, var. mediation of 386 species 521, 522, 542, 543 release in 46 differential metabolism, var. species 542, histamine stim., inhibition of 253-255, 543 257, 505, 506 N-oxide 543 by burimamide 259 Fenethiazine (Fenethazine) 447,448 by cimetidine 264, 265 Feniramine 236 by guanylhistamine 255, 256 Fenpiprane 226 by imidazolylpropylguanidine 257 Ferritin 575 by metiamide 264 Fick's law 312 inhibitors stim., of HDA by 45 Flufenamate 477 insulin stirn., inhibition by burimamide Fluoformylon 475 259 Fluoride (sodium) 518 histidine carboxylase in 110 as inhibitor of glycolysis 94 measurement 254 2- and 4-Fluorohistamine 163 model for 46 Fluorometric method for histamine 109, 110 pentagastrin stirn., inhibition by burima• Fluphenazine 537 mide 259 biotransformation products 538 by cimetidine 264, 265 metabolic studies 537,538 by metiamide 264 metabolites, dog 538 role of histamine 41,48 Foralamin (methafurylene) 383 stirn. by gastric mucosa extracts 41 Formaldehyde 186,203,521,522,542 by histamine 41 Forssman shock, action of AH 467,468 by pentagastrin 48 histamine levels in 467,468 vagally ind., inhibition by burimamide platelet and granulocyte segregation in 259 467, 468 fistula 47, 50 Fourneau compounds 386,405,470 mucosa 48 Free energy decrease 299 mucosal blood flow 53 diagrams 298 Gastrin 41-51, 54 function 296,297,309,310,316 activation of HD by 48 Free and Wilson, equation 231 effect of high doses on gastric secretion 49 model for SAR studies 231,232 on oxyntic gland mucosa 48 Freund's adjuvant 114,474 endogenous 44, 45 Fructose 95 as gastric secretagogue 41-43 Furtrethonium 334 and histamine release 44 and HDA 43-45,47 Gaddum's equation, competitive antagonism release of 44, 45 391 serum levels 47 Galactose 95 stirn. secretion, inhibition of 54 Gamma-globulin, aggregation 60 trophic action of 45, 54 in mast cells 60 Gastrointestinal bleeding, and AH 505, 506 Ganglionic blocking agents 416 GD-121, 320 Subject Index 675

Glucagon 382 double reciprocal plots (see also Double Glucocorticoids 110,282,464,475,577 reciprocal plot) 316 and HDA 119 as mediators of 14C-histamine, stomach Hageman factor activation, action of AH 117 510 Glucose 63 f3-Haloalkylamines 302,314,315,318,320, 14C 98 322-324, 390, 396 production of 14COZ and lactate from Halopyramine 180 98 Hammett sigma (0") constant 215,227,231, exogenous and histamine release, mast cells 239,244,355 99-101 Hansch approach (technique) 216,231-234, and histamine release 98-101 334 metabolism 551, 552 for cynnamylamines 233 stirn. by hist. releasers, mast cells 58 for 1,l-diaryl-3-amino-propenes 233 role in histamine release 93, 94 for diphenhydramines 232,233,239, Glucuronic acid 526 240 f3-Glucuronidase 526 inclusion of optically active structures Glutamic conjugation, sev. species 520 239 Glycogen 412 SAR equation 231 Glycolysis, as energy provider 99 model 227, 231 and histamine release 59, 99 HD (see Histidine decarboxylase) inhibitors 94 HDA (see Histidine decarboxylase activity) Glycopyrronium 338, 350 Heart anaphylaxis, action of AH 457-461, Glycosides, steroid alkaloid 378 472 Glyvenol (Tribenoside) 448,474 acute, evaluation of AH 461 Gonadotrophic hormones 141 catecholamine release in 461 Granule(s), mast cells, cationic exchange disturbances 456, 457 proper. 87 histamine release in 459 expulsion 87 block 9, 11 extrusion 76, 77 anaphylactic 457, 460 heparin-protein matrix 85 failure, anaphylactic 452,460 and histamine release 59 in HLP 461 matrix 82, 85, 87 isolated 9-14 storage mechanism 86 -lung preparation (Starling, HLP) 14 uptake inorg. cations and amines 86 anaphylactic reaction in 459,461 zinc in 84 bronchospasm, anaphylactic 461 Granulocyte segregation 468 by anaphylatoxin 461 Granuloma, cotton pellet, and action of NAS interaction heart and lung anaphylaxis 378 461 Granulopexy 423 Hedonal 15 Gravitol 382, 386, 399 Heidenhain pouch 42,49,51-53,259 Grignard reagent 199 Helium 100 Guanethidine 463, 464 (X-Helix, protein, in reI. to H I-receptor and Guanidine derivatives, bioI. proper. 256, 265 HI-receptor antagonist 402,403 as histamine antagonists 257,258 Hemochromogen 575 pKa 265 Hemoglobin, as extracellular tracer (marker) in Guanidinium cation 256, 257 degranulation studies 79,81, 88 group 258 Hemophilus pertussis vaccination 475 ion 256 Hemorrhage(ic) 472, 577, 587 Guanylate cyclase 64 irreversibility of shock 589 N° -Guanylhistamine, as partial agonist shock, acute, in dogs 586 254-257, 259 in animals 589, 590 pAz 256 histamine release in 586 Guinea pig ileum after AH, var. condo 315, role of vasopressin 583 317-320 survival time 583 assay 205 therapy, by AH 589, 590 676 Subject Index

Heparin 83, 139,444,466,472 on basilar artery, rabbit 27 amount in mast cell granules 83 on blood pressure 2-6, 584 in basophil granules 82, 83, 88 on cAMP, heart 458 capacity to bind and store histamine 83,84 levels 401 commercial (bovine) 83 cardiac 7 fT. desulphated 83 flow 9,10,13,14,21 in granules 87,88 functions, parameters 7 fT. histamin complex, formation in vitro 83 intact animals 8, 11, 12 in granules 85 output 8, 11, 12 in vivo 82 cardiovascular 1 fT. importance of ester sulphate groups 85 on cerebral arteries 27 in mast cells 78 circulation 22 protamine complex 87 vasculature 13 protein complex 87 chrono-andinotropic 8-12,400,440,441 zinc-histamine, ternary compound in anaphylaxis 457-459,469,472 83, 84 in HLP 461 Hepatic microsomal system, influence by AH mediators of 401 (see also Enzymes, liver microsomes) 563 on CNS, arousal reaction 568 Hepzidine-N -demethylation 548 efTect of AH 568 3H and 14C, metabolic rate and distribution by RF stirn. 568 547 block by AH 568 3H, hydrolysis 548 cerebellum depression 568 maleate, 14C, accumulation in mouse organs circulation 568 and CNS 548 cuneate nucleus depression 568 autoradiographic studies 548 efTect of AH 568, 569 metabolites 548 hypothalamic hist. conc. 568 metabolic studies 547-549 neuron excitation 568 Hetramine (2971 RP) 381, 383, 408,447,449 hypothermia (i. v. injection) 568 Hetrazan 510 by iontophoretic applic. 568 "Hexahydro"-diphenhydramine 244 RF depression by 568 Hexamethonium 400, 466 RF induced potentials, action of AH Hexobarbital 562 568 hydroxylation, strain difT. 521 on coronary blood flow 21 metabolism, action of orphenadrine 552 on coronary perfusion pressure 21 infl. of chlor- and norchlorcyclizine 529 on delayed hypersensitivity 440 liver metabolism, action of chlorcyclizine on diastolic pressure 2 550 dromotropic 8-12 potentiation by AH 562 in anaphylaxis 440, 459 rate and sleeping time, measurement on endothelial cells 26 fT. 549, 552 on force of contraction 12, 13 Hippuric acid 531 on forearm and circulation 22 Histadyl (see also methapyrilene, Thenylene) on glands (exo- and endocrine) 22 180,182,381,383,387,398,408,415,420 on heart block 9, 11 action on CNS 563, 564 in HLP (Starling) 14,15,461 Histadyl-l 415,418 hypertensive 2, 3 Histadyl-3 415,418 hypotensive 2, 3 Histaminase (see also diamine oxidase) infl. of age 7 132, 134, 141,472 of ionic changes 29, 30 release in anaphylaxis 472 of sex 7 Histamine 260-262, 338, 342, 390, 423, 505, in isolated heart prep. 9-14 575, 582 on liver circulation, action of AH 22 action(s) (or efTect(s)), anesthesia efTect 30 on liver-portal vein 17, 22 on arterial pressure 2, 4-7 on lungs, isolated 15 arrythmias by 9 on mammalian circulation 27 on atrial pressure 16 metabolic and pH requirements 27 on atrial -ven tricular dissoc. 11 microcirculatory 1, 22-25, 29 on auricular artery, rabbit 27 vasoconstriction 22 Subjeet Index 677

Histamine endogenous inhibitors 120 vasodilation 22 half-life 120 on musculo-cutaneous circulation 22 specific function 121 on myocardium 12 turnover of 120 on nerve excitability 420 14C 113,121,133,135-141,375 on pancreas circulation 17 exogenous 114 and perfusion pressure (PP) 14, 15 formation 113, 114, 116-118 peripheral vascular resistance 4--6 in adrenolectomized mice 119 pharmacological 1 ff. in brain, mouse 121 on permeability of microvasc. cells 113, effect of hormones 119 114 in gastrectomized mice 113 on portal vein pressure 3-5, 22 granules charged with 85 on precapillary sphincter 23 metabolism in sev. spec. 115 on pulmonary artery pressure (PAP) 15, and metabolites, in urine 115 16,21 cardiovascular effects on calf 7 blood flow 21 cats 4,6-10,12,14,16-19,21,22 vasculature 21 dogs 4,8,9,14,16-19,21,22 venous pressure (PVP) 15 g. pigs 4,9, 10,14,21 on regional vasodilation 1, 13 ff. 23 horse 6, 16 on renal circulation 22 man 6-8, 11, 16, 19-22,27 vasculature 13 rabbits 3,8, 10, 14, 18,21,27,29 sex diff. 6, 7 rats 2,9, 14,21,25 on splanchnic vasculature 21 catabolism 117,134,138 in splenectomized animals 5 inhibition of 114 on SRS-A release 440 catecholamine release by 400,401,463 in Starling-HLP 14,15,461 chern. diff. with its receptor antagonists 284 on superior mesent. artery (SMA) 15-17 chronic treatment 138 on systemic vasculature 1-3 cleavage of imidazol ring 138 on thoracic aorta 28 components of action on g. pig coronaries on vascular permeability 26ff., 584, 593 457 smooth muscle 1,23,27,29 conditions as mediator of shock 584 on vena cava pressure 4, 5 conjugated 136-139, 141 on venous pressure 2, 4-7 content, gastric mucosa 45 central 3 guinea pig, sev. organs and body fluids aerosol 138, 194, 215, 369, 370, 378, 406, 167 446,448,449,451,465,466 man, breast carcinoma 168 evaluation of AH 465 keloid 168 protection by AH 389, 390 sev. organs and body fluids 168 symptoms 406 mast cells (granules) 78,80,87-89 in animal kingdom 23 mice, ascites tumor 166, 167 assay, biological 151 sev. organs and body fluids 166 enzymatic isotopic 151 ff. rat, sev. organs and body fluids 166,169 fluorimetric 151, 162, 165, 168 in tissues 166, 167 ion exchange column chromatographic depletion of var. cells, action of AH 510 proc. 151 destruction by boiling 164 autoinhibition 346,348-350 organs of 468 binding and release, molec. basis 58 derivatives as AH 381 capacity of granules 86 determination, enzymatic isotopic method to heparin 83, 84 120 protein complex 84 fluorimetric method 109, 110 zinc 84 isotopic methods 122 biphasic responses to 2-4,6-8, 13, 14, 16, 19 distribution, in blood 139 biosynthesis 109 ff. in brain 169 and blood-brain barrier 121 in skin, human 112 in blood vessels 23 in stomach, sev. species 112 in brain 122 in tissue 54 effect of reserpine 120 in upper digest. tract III 678 Subject Index

Histamine dual action 441,477 in fetal mouse tissues 116 edema by 505, 506 tissues 119 efTect on histamine release 61,62 in gastric secretion 43, 110 in inflammatory processes 440 in hypophysis 114 on pepsin secretion 54 in hypothalamus 121 on rabbit aorta strip 508 in inflammation 505 on rat uterus 252, 263 by in test. bacteria 115 "endogenous" 48,140,141,440,452,460, isotope assay 111 478 in mucosa 48, 54 and acid secretion 49 rate of 111, 138 in endotoxemia sepsis 593 in rat skin, allograft rejection 116 in enterochromffin cells 115 stirn. by antigen 113 enzymatic isotope assay 151 fT. in stomach 113 assay blanks 162, 163 studies on 114 diff. procedure 164 in vitro 110,113,115,116 double isotope assay 152-164 in vivo 113-115 conditions for 158 inhibition of 117, 118 interferences 163, 164 forming capacity (HFC) after adrenaline isotope derivative dilution analysis 110 151-153 after exercise 110 modifications 164 of bovine endothelial cells 111, 112 precision 162, 163 of human leucocytes 106 single isotope assay 152, 161-164 increase by diff. stimuli 110 conditions for 158 of intima media 112 specificity 152, 162 of mast cells 106 use of 164-169 in mouse lung 113 excretion 114, 131 fT. in O2 want 110 in allergy 142 in pyridoxal-deficient rats 117 in animals 134-137 of rat and mice tissues 110 changesin 137-139 free 48 in blood diseases 142 function in stomach 54 in burns 142 in gastric juice 42 in carcinoidosis 143 as gastric secretagogue 46 changes of, man 140,141 and gastric secretion 41 fT. in starvation 137 feedback mechanism 43 in sweat 143 historical review 41 fT. in urine 132ff., 138, 140-142 hypotheses 41 action of cold 114 in gastrointestinal mucosa 41 of stressors 115 3H 109,110 after histidine 140 2,3-3H 160 in pregnancy 141 2,4- 3H 160 in sev. species 135-137 2(fJ)_3H 154, 157, 158, 160 sex diff. 134 preparation 155 in urticaria 143 3H formation, effect of anesthetics 120 "exogenous" 42,140, 141,399,440,441, of hypnotics 120 452,460,462,478 methylation, efTect of reserpine 120 stirn. of acid secret. 46, 48 ring labeled 160, 165 feeding of 138 HD activation by 24 in feline tissues 133 and HD inhibitors, in brain 116 formation 109,122,131,132,134,137, 138, imidazol ring of 176, 283 142 inactivation 131, 132 action of AH 121, 122 in rat tissues 133, 134 in brain 119-121 infusion 3, 7 double isotope procedure as measurement interaction with AH 2 of 109 with endothelium (vasc.) 24 effect of hormones 119 with mediators of inflammation, action sex hormones 138 of AH 506-508 Subject Index 679

Histamine intradermal 509 in sev. species 135-137 "intrinsic" 23, 24, 441 side-chain methylation 133, 139 as intrinsic regul. of capillary blood flow in tissues 132-134 122 metabolites in brain 121 itching by 506 metabolizing enzymes 164, 169 levels in anaphylaxis, rat 472 measurement of 164-169 in blood (plasma) 452 methylated derivatives 132, 136, 142 in cerebral cortex 121 turnover of 143 in cortisol treated mice tissues 119 methylating capacity 139 in cow's milk 137 enzyme (see Histamine-N-methyltrans• in heart \16 ferase) 114, 132 in hypothalamus 120,121 methylation (see Histamine, metabolism, in stomach 116 methylation) in tissues, rat 117 microcirculation theory 122 in urine 116 and microcirculatory phenomena 24, 109 lethal dose 447--449,451 mucosal 54 in leucocytes 113 content 48 -like substances 505 release 54 correl. diff. effects 252, 253 as neurotransmitter in brain 109, 119, 120, in mast cells 23 568 mechanism of action on blood vessels 2 new synthesis by HD 584 as mediator of anaphylaxis 439,442 non mast cell 115, 120 of gastric secretion 41,42,386 and normal physiology of gastric mucosa of inflammation, early phases 118 54 of pain 417 numbering 252 of parasympathetic salivation III origin in pituitary gland 114 of prostaglandin release 443 oxidation (see Histamine metabolism, of reactive hyperemia 386 oxidation) in regulation of vasco permeability 386 participation in non-allergic inflamm. pro• of shock 584ff. cesses 386 of trauma by Noble-Collip drum 593 in pathophysiological processes 386 of vascular responses 506 in shock 386 metabolic detoxification 375 partition ratio 280 pathways 131 pathophysiological effects 584 metabolism 131 ff. in pentagastrin stirn. secretion 50 acetylation 139 perfusion (kidney, stomach) 18,53 in allergy 142 physiological actions 584 in anaphylactic shock 134 roles \09 in animals 134-137 stimulation of gastric secretion 41,42 changes of 137-139 physiological regulator cardiovasc. system 1 and antihistamines 444 local blood flow 23 in blood diseases 142 in plasma or serum, in anaphylaxis 585, in burns 142 586, 588 effect of barbiturates 120 in burns, scalding 586,587 of burn injury 137, 138 correl. with intensity anaphylactic shock and excretion \09ff., 131 ff. 588 in human tissues 139-140 correl. with intensity of shock 585, 594 methylation 131-134,138,140,142,160, in endotoxemia sepsis 585-587 169 in hemorrhage 585, 586 effect of sex hormones 138 increase, whole blood 585, 586 in mouse 135 infl. immune host deficiency 586 and oxidation in man 139 infl. RES 586 in several species 135-137 infl. time of sampling 585, 586 rate of 133, 134 and metabolism 585 oxidation 131-133,136,138-141 methods of assay 587 oxidative deamination 133-137 and neuroendocrine functions 585 role of diamine oxidase 132 in shock 585, 586, 594 680 Subject Index

Histamine from cat skin 93 circulatory 585, 586, 594 by cation exchange 88 septic 585 cell membrane permeability in 59 in trauma 585-587 cellular and subcellular process in mast pK.'s 344 cells 75 poisoning 478 and CO2 production 100 potentiation of inflammation by 505 stimulation 99 radioactive (see also Histamine 14C, and 3H and complement (activation) 60 24,131-133,136, 142 complexity of problem 68 metabolites 131, 136, 138, 139, 142 by compound 48/80 57, 58, 60, 106 radiochromatographic microassay 110 action of inhibitors 94, 95 receptor(s) 122,341-345,348,381,395 and ATP content of mast cells HI-(see Histamine HI-Receptors) 102, 104, 105 H2-(see Histamine HrReceptors) effect of sev. substances 102-104 identification by antagonists 251, 252 enhancement 98 model 385 and O2 consumption 98 second anchorage group 381 from rat peritoneal mast cells 96 site, anionic 256 resistance to anoxia 93 stereochem. requirements for blockade contractile proteins in 59 185 control mechanism 61 ff. vascular 24 cyclic AMP in 61,62 regulation (tissue) blood flow 25, 584 cyclic nucleotides 61,62 release (secretion) 54, 131, 133, 137, 138, by cytotoxic mechanism 58 143 and degranulation (mast cells) 59,79,96 action of 2-deoxY-D-glucose 66 and desensitization 61,66 of dibutyryl cAMP 66 in dextran shock 164 of isoproterenol 66 by diff. stimuli 57 of prostaglandin 66 and edema development 167 of theophylline 66 electron-microscopic studies 59 active state induced by releasers 65, 68 in endotoxin shock 164 aggregation of gamma-globulin 60 as energy-quiring secr. process 58 in allergy 421,509 enhancers 62ff. anaphylactic 88,93,96, 100, 113,440, exchange with extracellular cations 88 443 exogenous glucose in 99 action of inhibitors 94, 95 extrapulmonar 452 and ATPcontent of mast cells 101-103 extrusion of granules and 59 energy metabolism 93-95 and gastric (acid) secretion 43, 46 inhibition by anoxia 93 from (gastric) mucosa 43,48 respir. of g. pig lung 97 by gastrin 44,47 by anaphlatoxin, action of AH 443, 452 general problem of 57 ff. in anaphylaxis 386, 508 glucose-dependent inhibition of 94, 95 heart 457 by heat 386 rabbits 470 from human basophils 57 rat 471, 472 leucocytes 57 by animal venoms 386 in inflammatory reactions 507 in anoxia 99 inhibition of 510 by antigen 57, 58, 60, 98, 105, 106 by f3-adrenergic agonists 61 by antihistamines 122,442 by cholera toxin 61 by antisera 60 by cholchicine 59, 63 into arterial circulation 42 by 2-deoxyglucose 94 by ATP 58,65 by DFP 59 and ATP content of mast cells 98-105 by inhibitors of glycolysis 59 by basic drugs 58 of resp. chain 94 by basic peptides 60 by low temperatures 59 in brain, by K + depolarization 568 by phosphodiesterase inhibitors 61 in burn injury 164 by prostaglandins E I and E2 62 by calcium ionophere (A 23187) 64-66 by secretin 47,48 Subject Index 681

Histamine endotoxins as 60 by sulfhydryl reagents 59 immunologic and non immunologic 57, by theophylline 61,62 58 inhibitors 62fT. interaction with specific receptors 59 intracellular mechanism 88 mammalian kinins as 60 lactate production 99, 100 vasoactive peptides as 60 lanthanum experiments 65 and reversal of burimamide inhib. of gastr. by lectins 58 secr. 46 local, in anaphylaxis, assay of AH 399 rise in pulmonary resistance 453,454 lungs, human asthmatic 398 rodents response to 2 rat, in anaphylaxis 472 role in anaphylaxis, sev. species 470-476 sensitized, exposed to antigen 164 in brain 122 from mast cell(s) 59-67 in carrageenan edema 507 granules 89 in Forssman shock 468 mechanism 75fT. in gastrin-indo secretion 50 metabolic changes 93fT. in inflammation 505 steps of 87 SAR 256 and mast cell metabolism 105 secretion, and dye permeability 58 by mechanical trauma 386 and enzymatic reactions 59 mechanism 442 noncytotoxic nature 58 from membrane-free granules 82, 86, 93 sensitivity towards guinea pig ileum, after by mercury salts 386 AH, efTect of temp. 315,317-320,322 and metabolic inhibitors 95 shock, action of AH 446--450,452,468, by metiamide 440 588 modulation by cAMP 61 in difT. animal spec. 590 bycGMP 62 noncytotoxic 57,58,68 potentiation by AH 589 from organs 67 treatment with AH 589 from platelets 67,68 in mice 589 role ofCa 68 in dogs 589 by polymer amino acids 58 survival in 588 prostaglandins as modulators of 443 as "shock toxin" 584 from rat peritoneal mast cells 57,88 similarity with nonadrenaline on g. pig pleural mast cells 88 coronaries 457 tissue, role of glucose 93, 94 specific receptors for 1, 2 in reactive hyperemia 422 standard 157-162 requirement for divalent cations 58 stirn. acid secretion, action of atropine 51 role of Ca 65, 66, 105 of metiamide 51 role of cAMP 105 stirn. of gastric secretion 252-255 256 serine esterase in 59 257,259,264 ' , in shock 593 stirn. of isolated atria 252, 259, 263, 265 similarity in mast cells and tissues 67 stirn. of RES 423 by sodium 86 in stomach 112 specific receptors for 57, 59 storage in granules 85 stages of 65, 66 in mast cells 83 stim. of exog. glucose metabolism by var. stores, gastric mucosal 43 releasers 10 1 in stressed animals 23 from tissues, inhibition of 67 structure, modifications of 253-255 and tissue injury 167 in reI. to AH 176 in tourniquet shock 164, 166 subcellular locus in rat hypothalamus 121 in urticaria 164 4-substituted 278 releasers 57, 58,423 in synaptic vesicles 120 anaphylatoxins as 60 synthesis 140 cationic pep tides as 60 systemic administration 213 and cell depolarization 59 systemic vascular actions 2fT. cleavage products of complement as 60 in tissues of inhibitor-treated mice 114 complement peptides as 60 toxicity of released 406 682 Subject Index

Histamine triphasic responses to 3, 12, 13, partition ratios 280 21,24,25,29 as therapeutical agents in allergy 440 triple response in skin 420,421 Histamine H2-Receptors 2, 3, 7, 21, 24, 25, action of AH 421 29,284,386,417,421,440,458,459,469, turnover 131 470,473,477-479,505,506,593 in brain 568 action of antagonists 576 uptake, effect of AH 443 in atria, g. pig 11 by mast cell granules 86, 87 definition 253 by membrane-free granules 86 effect of burimamide on 53 and metabolism 440 of histamine on 49 urinary 42, 138, 142, 143 and gastrin receptor 50 in female golden hamster 119 in microcirculation 506 source of 114 stirn. and cAMP 459 and tissue inhibitors of newly formed in ventricular muscle 11 117 Histamine H2-Receptor Antagonists (see also vasodilator effect 252, 593 Antihistamines) 3, 11, 12, 21, 25, 27, 29, Histamine Hl-receptor(s) 3,12,13,21,24,25, 30,42, 49ff., 118, 134,440,454,455,458- 29,252,260,424,440,457-460,469,473, 460,463,476,478,505 475, 478 absorption and distribution 280,281 action of AH 390, 402, 403 action on histamine receptor 51 blockade 507, 508 activities 263, 285 complex formation with phenoxybenz• burimamide, as compel. antagonist of amine, effect of temper. 320--322 histamine 259 in g. pig heart 401 development 256-260 interaction with AH 295, 390 chain length in 279 and protein IX-helix 402 chemical constitution 267ff. quantitative studies 390 chemical mode of action 277-280 "intrinsic" activity 296 chemistry 251 ff. isolation 295 cimetidine, as competitive antagonist of hist mechanism of interaction with AH 425 265 nature of 296 development 265-267 parameters 0f affinity 296 physico-chern. proper. 266,267 recognition 285 as competitive antagonists 278 site 175 conformational analysis 279 site of competition with AH 403 design of 253-256 Histamine H I-receptor antagonists (see also dissociation constants 256, 257, 260, 261 Antihistamines) 3, 11, 12, 22, 25, 27, 29, 263-265 ' 30, 175ff., 280, 459, 460, 468,476,478,505, effect on cAMP 401 510 on histamine action, heart 401 activity 216 "efficacy" 278 binding to "annex" part of receptor 402 on gastric secretion 50, 51 chern. diff. 283-285 stirn. by his!. 253, 254 classification 216 heterocyclic analogues 278 integrated QSAR 249-254 hydrogen bonding 279 SAR 215ff. importance of imidazol ring 264 stereospecificity 225 "intrinsic activity" 278 Histamine HI and H2 Receptors in arterial metabolic studies 552-554 responses 506 metabolism and elimination 281-283 action of histamine on 21 metiamide, development 260-264 cardiovascular, dog 469 physico-chemical proper. 266, 267 in coronary bed 457 specificity 264 in peripheral vessels 585 molecular structure 278 in pulmonary vasco bed 477 pAl' calculation 393 Histamine HI and H2 Receptor antagonists pharmacokinetics 280-283 (see also Antihistamines) in reversible assoc. complex 278 anaphylaxis, rabbits 470 SAR 251ff., 277 effect in urticarial allergy 421 "stacking interaction" 279 Subject Index 683

Histamine H2-Receptor as stimulator of in fetal tissues 119 HDA 45 after histamine 44 and trophic actions of gastrin 45 and inhibitors of protein synthesis 118 Histamine-N-methyltransferase 132, 151, after insulin 112 154,160-163,165,169,205 in kidney, pregnant mice 110 assay of 169-171 in leucocytes, in patients with myelopro• content in human tissues 139 liferative disorders 110 effect of AH 444 in liver of tryptophan-deficient rats 110 inhibition of 134 rats with virus-indo sarcoma 110 preparation (g. pig brain) 155-157 methods for determination mammalian subcellular locus in rat hypothalamus 121 tissues 109, 110 Histaminergic fibers, degeneration 120 after pentagastrin 112 system (g. pig ileum) and competitive anta• in pregnant hamster 110 gonists 334,339-341,343,345,348, in rats with Walker mammary carcino- 350, 360, 362, 363 sarcoma 110 affinity values 341,343, 351. 353, 360 after reserpine 112 pA2/pD2 ratios 349, 350 in skin allografts and host spleen, rats pA2 values 336,337,339,351-359,362 110 pD2 values 336, 337, 339 skin, g. pigs, during tuberculin reaction pD2 values 336,337,339,350,351. 353, 110 355-359 in spleen, rats, after immun. 110 comparison to cholinergic system stimulation by cholecytokinin 44 350, 351 by 2-deoxY-D-glucose 43,44 and van der Waals volume 361 by gastrin 47 Histaminol 131, 136, 139 by Hrreceptor antagonists 45 Histaminomimetics 342 by inhibitors of gastr. secr. 45 Histantin (see Chlorazine) by insulin 43, 44 (L-) Histidine, as AH 300, 381 by pentogastrin 44 assay 161, 164-169 by urecholine 43 14C 24,85,113-115,117,118,121,131, after starvation 112 132, 134, 138, 140, 163, 170 in stomach and urine, rats, after nicotine decarboxylation 131, 140 110 feeding 138 telencephalon 120 (/3) 3H 115, 120, 155 in tumor, rats 110 as label for cellular histamine 80 in urine, rat 110 oral loading 141 in vagotomy 44 plasma concentration 140 after X-irradiation 112 pool, decarboxylation 120 assay of 161,169,170 Histidine decarboxylase (HD) 23-25,29, in brain 109 43-45,47,48 measurement of 14C02 110 "acid and alkaline" III bacterial 155,169,170 action of nicotine on 114 in bone marrow, rats 110 activation 25 in brain 568 and deactivation 118, 1I9 diff. enzymes 116 by endotoxin Ill, II3, 114 distribution, skin, human 112 and gastric secretion 43, 112 stomach, sev. species 112 by gastrin 48 upper digestive tract . III by histamine 24 fetal III activity (HDA) 23 in gastric mucosa, sev. species III in anaphylactic reaction 110 in gastric secretion 110 in bone marrow, sev. species 110 gastric stimulation of 444 in brain, proper. 119 and histamine formation 109 regions, sev. species 121 in immunosympathectomized rats 112 subcellular distrib. 119 increase in stomach 115 in synaptosomes 119, 120 induced 584 effect of hormones 119 inducibility 110, 122 afterfeeding 112 inducible type 109 684 Subject Index

Histidine decarboxylase (HD) induction 113 Hydroxylation, amitriptyline 545, 547 inhibition 116 aniline, strain diff. 521 by tx-hydrazino-histidine 113 chlorpromazine, ring C-7 and C-3 539 in skin and stomach, mice 117 cyproheptadine, ring 544 inhibitors 111,112,115,116 dimetotiazine, ring 541 insoluble 112 fenethazine, ring 543 isotope dilution method 112 hexobarbital, strain diff. 521 kinetic properties 111 imipramine 547 in rat lung, and corticoids 110 isothipendyl, ring 543 role of 118 trimeprazine, ring 543 after rotating drum trauma 112 tripelennamine 526 in skin wound, rat 110 4-Hydroxymethyl-5-methylimidazole 286 stirn. by atropine 45 5-Hydroxytryptamine (see also Serotonin) by prostaglandin 45 163 by SC15396 45 14C 85 in stressed rats 112 Hydroxyzine 530, 566 subcellular locus in rat hypothalamus 121 antianxiety effect 566 Histidine decarboxylating enzymes, specific 14C-benzylcarbon, metabolic studies, rat and non specif., in thymus and thyroid 111 530, 531 Histostab (see also Antistin, antazoline) 381, passage through hepatic tissue 530,531 383,387,407,413,415,417,418,443,446-449, comparison with phenobarbital 566 451,454,508,510 concentration, rat organs 530 Histryl (see Diphenylpyraline) concentration gradient, rat organs 530 lH-nmr resonance 182 effect on EEG 567 H-NMR (PMR) spectroscopy 186 hypnotic effects 566 Homeostasis, autonomic regulation 581 inhibition by physostigmine 567 local, tissue 581 N-oxidation 531 mechanisms, 581, 582. N-oxide 531 of microcirculation 581 in psychiatric patients 566 in shock 580 .. L-Hyoscyamine 304 Homochlorcyc1izine 443, 448 Hypercapnia 582 Hormones, and histamine formation 119 Hyperimmunization 452,453,462,471 H-Substance 399,455 tx- and P-blockade in 453 5-HT (see Serotonin) Hyperosmoticity 582 Hiickel theory, extended 279 Hypersensitivity, delayed, action of hist. on Hydergine 470 440 tx-Hydrazino-histidine (txHH) 116, 117 reactions 167 as inhibitor of HD 113 Hypnotics (see also Barbiturates) 549 Hydrocortisone 507 and histamine formation 120 Hydrogen bond(s) 271-273 potentiation by AH 562 bonding 256, 257, 259 Hypolipemic drugs 549 and anti H2-activity 279 Hypotension, anaphylactic, action of AH ion(s) (H +) 582 468, 470 and gastric secretion 43 PVP-induced 469 peroxide 518 Hypoxemia 582 Hydrophobic binding 402, 404 fragmental constant 240, 244 IgE 61, 68 interactions 362, 366 anti Rat Fab 105 at receptor site 302 immunoglobulin 60 properties and AH activity 241 receptor 59-61 p-Hydroxybenzophene 527 sensitized tissues, hist. reI. 64 2-Hydroxy-5-carbomethoxy benzyl ox amine, as specific receptors for 61 HD inhibitor 117 type antibodies 474,475 ll-Hydroxycorticosteroid levels in protracted Ileum, g. pig, assay of AH 178, 179 shock 464 Imidazole(s) 122, 261 Hydroxydoxepin (glucuronide) 547 derivatives, partition ratios 280 Hydroxylamine 518 partition ratio 280 Subject Index 685

Imidazole(s) ring 267,271-273,278,279, Integrated QSAR of H I-receptor antagonists 283, 284 240-244 chemistry 278 Interacting receptor theory 51 derivatives 284, 285 Interfacial tension and anti-H I activity 228 dissociation constant 263, 264 Intestinal musc. tone 583 hydrogen bonds 271,272 tract, ischemia hypoxia 583 importance for anti-H2 act. 264 musc. circulation 583 pK a 263, 264, 267 release of serotonin 583 ribbon 272 "Intrinsic activity 279,296,333,334, 343, 352 Imidazoleacetic acid 131,132,137,139,141 constants 364 riboside 131 values 336, 337, 339, 340, 364 urinary excretion 138-140 Iodine 281 Imidazole-2-thione lodoacetate 94, 518 Imidazoline ring 181 Ionic bond, at receptor site 302, 322 4-Imidazol yl- 3-aminobutenone forces 402 (McN-A-1293), as HD inhibitor 116 Ionization constants and anti-H I act. 227 Imidazol-4(5)-yl methoxamine 115, 117 Iproniazid 134 3-(Imidazol-4-yl) propylguanidine 257 (I)-Isoprenaline 113,260,264,365 pA2 257 Isoproterenol 24, 163,453,468,472,477 a partial agonist 257 and histamine release 66 Imidic ester, HCl 181 Isothiouronium structures 257,258 Imipramine 462,521,533,546,547,550 Isothipendyl (see also Andantol; D201) 409, action on liver micros om. enzymes 550 410, 415 N-demethylation 547 differential metabolism, liver, sev. species hydroxylation 547 542, 543 inhib. of chlorcyclizine accum., lungs 547 N-demethylation, liver, sev. species 521, metabolism, major routes 547 542, 543 N-oxidation 547 N-oxide 543 Immunofluorescence techniques 26 Isotope(ic) assay, for hist. formation 111 Immunoglobulins 60 derivative dilution analysis 151,152 Inhibitors of histamine release 62 ff. applic. in bioI. work 152, 153 Inderal 300,304,313 dilution method for HD 112 Indomethacin 118,472,474,507,509,510, methods for hist. determ. 122 584 IUPAC, stereochemical nomenclature 180, Indomethyazine (Indomethacin) 476 233 Indopamin 206 Indoramin 206 KB, as affinity constant 178 ff. Infection, acute, action of NAS 374 Kallikrein inactivator 472 chronic, effect of NAS 374 Ketosteroid 369 Inflammation(s), absence of action of AH 510 Kidney, juxtaglomerular cells 583 action of NAS 378 renin in 583 and HDA 118 Kinetics of antagonist action 295[[. histamine as mediator of early phases 118 Charniere theory (effect) 295-312 potentiation by histamine 505 Kinin(s) (see also Bradykinin) 413,422,423, role of histamine 505 453,476-478,576,582,583 in skin, by dermatophytes 509 antagonists 453 by sodium urate 508 formation 476 Inflammatory joint disease 506 as histamine releasers 60 processes, effect of histamine 440 release, action of AH 510 non allergic 386 Koch's postulates 507 reaction 386,475,509 Krebs cycle 582 mediators of 423 release of histamine in 507 L-583232 313 Inhibitors of oxidative metabolism, in hist. Lachesine 296,326,327,413,415 reI. from mast cells 100 Lactate and histamine release 99 Inotropic action 8-12 changes in mast cells 100 Insulin 43-49, 112, 163,259 Lactic acid 576, 582 686 Subject Index

Lactic dehydrogenase 58, 79 Main stomach 51-53 and hist. reI. from mast cells 106 Mannich base 186, 189,203 LangendorfT preparation 9, 10 Mast cell(s) 17,23,57-62, 112, 118,441,459, Lanthanum, action in mast cells 65 505,510 crystal ionic radius 65 action of lanthanum 65 experiments in hist. reI. 65 ATP content, changes in hist. reI. 101-105 as extracellular tracer in degranul. studies basal respiration rate 95 79, 80, 88 basophil granules in 75 Largactil (see chlorpromazine) in brain 121 Law of mass action 86 composition of 78 Lecithin-cholesterol monolayers 228 degranulating agents 78, 79 Lectins and histamine release 58 degranulation 466 Lergigan (see also Phenergan, promethazine; destruction, by anaphylatoxin 459 3277 RP) 381,388,389, 398, 401, 405, 407, by compound 48/80 459 410,415,417,418 disrupting agents 57 Leukemia, basophilic 168 disruption, anaphylactic, action of AH myelocytic 142 443,473 Leukocyte(s), basophilic, hist. reI. from 57 dopamine in 75 extracts 369 electron microscopy 75 human 443 energy metabolism 95, 96, 105 hist. reI. from 57 granules, exocytosis 75,93 sensitized 64 in guinea pig 78 Leukotaxin 575 lung 93,97 Linadryl 449 sensitized 106 Lineweaver-Burk inversion 46, 395 histamine in 75 Liothyronine 119 release from 58 fT. Lipophilicity 240, 244 glucose metabolism changes 98-101 and action of AH on CNS 285 mechanism 75fT. Liquid scintillation 153, 154, 158, 159, 171 metabolic changes 93 fT. Lipids, in mast cells 78 respiration changes 97, 98 Liver necrosis, by CCl 4 228 Local anaphylaxis (Arthus phenomenon), uptake and metabolism, mouse 440 action of AH 412 and immunoglobulins 60 Local anesthesia, by AH 417-420 light microscopy 75 Local anesthetic(s), action on anaphylaxis in membrane, conformational and ATP vitro 418 changes 105 action of AH and liposolubility 419,424 normal, morphology 75, 76 antianaphylactic activity 463 partial degranulation 75 antihistaminic activity 417,424 pure suspensions 75 comparison with AH 567 rat 57, 79 correlation of activity with AH activity lung 93 417-420 peritoneal 75, 88, 94, 96, 97, 99-102, EEG changes by 567 104-106 methods of measurement 417 glycolysis 95 pC, reI. to pA2 of AH 418 hist. reI. 94 Logistic function, for pA2 determ. 393, 394 and CO2 production 100 Logits, method for pA2 determ. 393 respiration 95 Low-flow (state) syndrome, lethal outcome sensitized, O2 consumption 97 579 pleural 75, 88 microvasc. injury 579 relationship between morphol. changes and RES depression 579 amine reI. 75 LSD 470,475 respiration and anaphylactic hist. reI. 98 Lysine 286 changes in hist. reI. 97, 98 Lysyl ethyl ether 286 sensitized 64, 80 sensitizing (MCS) antibodies 473 Macromolecules, transport 26 serotonin in 75 Magnus technique 232 in skin 114, 115 Subject Index 687

Mast cell(s) stirn. of exogenous glucose action on CNS 563, 564 metabolism 101 comparison with phenobarbital 564 Mastocytosis, NAS and 378 EDso (mol) 205 Masugi nephritis, action of AH 471 EEG of sedation by 564 Marzine (see also Cyclizine) 185 efTect on behavior 562 Matricial method, for pAz determ. 393, 394, in geriatric patients 564 396 infl. on REM sleep period 565 MCE 475 in insomniacs 565 MDF (Myocard. depress. factor) 576, 583 pain relief by 564 Mebhydrolin 204 pKa values 177 Mecamylamine 472 as sedative agent 564, 565 Mechanism of action of AH 295fT. stereoconfiguration 182 Meclizine (see also Meclozine; Postafen) Methapyrine 451 388,450,527 Methdilazine 197,449,537, 540 teratogenic proper. 527 metabolic fate, sev. species 540 Meclofenamate 453,472,476,509 sulfoxide 540 Meclozine (see also Meclizine; Postafen) Methiadene 200 388, 342 14C-Methionine 162, 163 in sea sickness treat. 185 Methixene 446 Melastine 184 4-Methoxybenzyl chloride 180 Membrane permeability and anti-H 1 activity Methoxyflurane 120 227 Methylamine, HCI 203 potential and degran. of mast cells 79 N -Methylaniline, N -demethylation 521 Mephenesin 536 2-Methylbenzhydrol 521 carbamate, metabolic studies 536 2-Methylburimamide 261,263,264 Mephenhydramine 220 1-Methyl-p-chlorobenzhydryl- Mepyramine (see also pirylamine, Neo• oxypyrrolidine 449 antergan, Anthisan; 2786 RP) 3, 25, 176, 218,251,252, 381, 383, 387, 389, 398, 399, 3-Methylcholantrene 552 405,407,412,413,415,417,418,421-424, 4(p)-Methyldiphenhydramine 221, 223-235, 444,446-455,458,459,461-478,506-510 338, 342 comparison with chlorpheniramine 207 derivatives 220, 242 conformation 182 Methyldiphenyl ketone 522 maleate 138 Methyl(diphenylmethyl-tri-O-acetyl-fJ-D- pAz values, difT. struct. 251 gl ucoside)uronate 520 pKa 177, 180, 182, 183 IX-Methyldopa 120 pKB 187 and urinary histamine 118 partition rate 280 Methylene blue 163 Mercury salts 386 Methylhistamine (l-methyl-4[fJ-aminoethyl ] Mereprine 387 imidazole) 121,131,134,138,141,142,154, Mesenteric term. artery 25 157,158,160,162,163,170,171 Metabolism of AH (see Antihistamines, IX-Methylhistamine 253 metabolism) 513 fT. 2-Methylhistamine 253 Metabolic changes in hist. reI. 106 fJ-Methylhistamine 253 inhibitors and hist. reI. 58,95 4-Methylhistamine 253,263,271 stirn. in hist. reI. 105, 106 N-Methylhistamine 342 Metactoid (non-competitive) receptors (see N X Methylhistamine 253 Receptors, metactoid) 2-4-Methylhistamine 259 Metacholine 410 Methylhistamine, during anesthesia and Methafurylene (Fora1amin) 383 surgery 143 Methanteline 398 14C 139,154,162 Methaphenilene (see also Diatrin) 381, 383, extraction and measurement 158, 159, 408,415,447 163, 164 action on CNS 564 destruction by MAO inhibitors 114 Methapyrilene (see also Thenylene, Histadyl) doubly labeled 109 180, 182, 381, 383, 387, 398, 408. 415, in feline tissues 133 420,447-45\ 3H 154, 162 688 Subject Index

Methylhistamine, development of 260-264 extraction and measurement 158, 159, dissociation constants 265 163,164 distribution, rat body 553 in human gastric mucosa 139 effect on HDA 45 tissues 139 equilibrium dyalisis 553 labeled 114 and gastric secretion 41,45,49-54 partition in chloroform: water 163 stirn. by 2-deoxy-D-glucose 52 quantitative determ. 131 by histamine 51 radioactive (see also 14C, and by liver extract 53 3H-methylhistamine) 114, 134, 140 by pentagastrin 52 unlabeled, as carrier 163 vagally 50 urinary excretion 134, 135, 140 3H or 35S labeled 281 in man 141 3H or 35S, metabolism 552, 553 (J(-Methylhistidine 115 urinary metabolites 553 4(5)-Methylimidazole 261,264,286 half-life, uptake into erythrocytes, var. partition ratio 280 species 553 Methylimidazoleacetic acid 135-137, heterocyclic analogues 278 139-142, 154 hydrogen-bonded species (struct.) 270, 4-Methyl-5-imidazole-methylthioethylamine 273,279 286 inhibition of gastric secr. 49 N-Methyl-N'-[3-(imidazole-4-yl)propyIJ stirn. by gastrin 50 thiourea 258 by hist. 505 pA2 258 local anesthetic action 288 Methyl isothiocyanate 285, 286 metabolism 281-283 S-Methylisothiourea 267 metabolites, potential 282 3-Methyl-MAB (see 2-Methyl-4- molecular structure 271 monomethylaminoazobenzene) in crystal 271, 273 2-Methyl-4-monomethylaminoazobenzene Newman projections 270 metabolism, and action of partition coefficients octanol: water 266, orphenadrine 552 267,279,280,283,284 liver microsomes, action of pharmacokinetics 280-283 chlorcyclizine 550 pharmacological actions 264 Methyl orange reaction, for AH metabolic physico-chern. proper. 266, 267 studies 513, 514, 516, 518, 519, 523 pK., apparent 261,263 comparison var. drugs 520,521 protein binding 553 1-4-(Methylphenyl)-1-(2-pyridyl)-3-N- in reactive hyperemia 422 pyrrolidinoprop-1-ene 385 ring-N-methylation 282 1-Methyl-4-piperidinol 548 rotameric forms 269 N"-(Methylthiocarbamyl)-histamine 279 35S, distribution pattern 554 N-Methylthiourea 267 formation of 35S-sulfate 554 Methysergide 468,472,473,475--477,509 side-chain demethylation 282 Metiamide (N-methyl-N' -[2-(5- specificity for Hrreceptors 54 methylimidazol-4-yl)-methylthioethyl] stable configuration 277 thiourea) 3, 25, 118, 134, 163, 263-267, steric interference 271 274,279,283-285,440,441,444,458,459, sulfone 282 463,472,476,552 sulfoxide 280, 282, 283, 553, 554 absorption and distribution 280,281 synthesis 285 and binding to plasma 280 tautomers 263,264,273 action on CNS 285 torsion angles for bond rotation 271 on pepsin secretion 54 Mg-ions 27, 28 as antagonist of H2-receptor 53, 54 Michaelis-Menten equation 46 of muscarinic receptor 53 Microcirculation 22ff. anticholinergic activity 285 autonomic regul. 591 chemical constitution 267-274 blood flow regul. 582 estimation, var. methods 281 constrict. or dilat. substances 581 correl. with pharmacol. responses 281 Microcirculatory components (musc.) 24 crystal structure 271 compounds 579-581 Subject Index 689

Microcirculatory effects of catecholamines content of organs and body fluids, bovine and sympathomimetics 579, 580 374 failure 577 dog 374 fraction 577, 578 frog 373 prep. 121, 122 g. pig 373 system 550 human 374 Microfilaments 59 lizard 373 Microfluorimetric techniques 88 rat 373 Microphysical model (receptor-antagonist toad 373 interaction) 309-312,315 methods of assay, g. pig ileum 371,372 binding energy 311,312 units of activity 372 calculation of parameters 310 of extraction 370,371 free energy function 309, 310 modification of amount 372-375 overall 309 diminution 375 potential well 309-311 elevation 374,375 vibration energy 310 seasonal var. 375 Microtubules 59,63 physical and chemical aspects 376 involvement in hist. secr. 63, 64, 68 molecular weight 376, 377 Microvascular permeability 24 solubility 376 walls 24 stability 377 Microvessels, meta-arterioles 577,-579 structure 377 post-arteriolar 577-579 steroids in 377 pre-capillary sphincters 577-579 from plants 378 term. arterioles 577-579 role of 377,378 venules 578, 579 specificity 376 Monamine oxidase inhibitors 114, 134 and stress 378 mucosal 45 as therapeutic agent Monocetyl phosphate 228 Nembutal 410 Morphine 163,300,304,312 N eoantergan (see also mepyramine, pyrilamine, barbital 8 Anthisan; 2786 RP) 180, 375, 381, 383, chloralosane 15 387, 389, 398, 399, 405, 407, 412, 413, chloralose 5, 8 415,417,418,421-424,444,446-455,458, urethane 8, 15 459,461-477,506-510 Motion-sickness, (anti-) (see also Sea- pA2 180 sickness) 183 Neobenodine (Toladryl) 388 Mucoitin sulfate 554 pA2 183 Multergan (3554 RP) 197,389,415,418 stereochem. conform. 183 Muscarinic receptor in cAMP controlled hist. Neohetramine (see also Thonzylamine, reI. 62 Anahist) 381,383,408,415,418 metiamide as antagonist of 53 metabolic studies 520, 521 Muscle relaxants 549 Neoplasias, effect of NAS 374 Muscular vessels, endog. constric. stirn. 580 Neoretamine, metabolic studies 520, 521 microcirculation 580 Neozine 300 Mydriasis by AH 416 Nerve-impulse-induced transmitter 89 Myeloproliferative disorders 110 Neurohypophyseal pept. antagonists 27 Myocarditis, serum-ind., action of AH 471 Neuroleptic drugs, piperazine-ring Myocardium 30 containing 530 Neurotransmitter, hist. as, in brain 109 Nicotinamide 163,551 Narcosal 4 Nicotine 110, 114, 141,400 ether 4,5,15-18 Nicotinic acid, interference with cyanogen Nasal mucosa decongestants 410,411 bromide test 515 Naturally occurring antihistamines (NAS) in p-Nitrobenzoic acid, reduction 521 body tissues 369ff. Nitrogen mustard 510 antiacetylcholine effect 375 Noble-Collip drum, infl. of AH on mortality antihistaminic effect 375 592,593 antiserotonin effect 375 Nocardia brasiliensis 471,472 690 Subject Index

Non-competitive (metactoid) antagonism effect on var. drug actions and metabolism (see Antagonism, non-competitive) 552 Non-competitive antagonists (see Antagonists, 3H benzy1carbon, metabolism 522, 523 non-competitive) concentration var. organs, rat 522 Non-steroidal antiinflammatory drugs HCl, N-demethylation 522 (antiphlogistics) 465,475 oxidative deamination 523 action on HD 116 metabolic studies 516-523 Noradrenaline (see also norepinephrine) 322, metabolites, mice urine 521 400,401,422,458-460,462-464,466,468, stirn. of ascorbic acid excretion 551 470,472 Osteocarcinoma 168 liber. by hist., heart muscle 400 Osmotic shock 120 as mediator at sympathetic terminals 386 Otrivin 300,313 similarity w. hist., g. pig coronaries 457 Oxaloacetate and basal respir. mast cells 95 turnover in brain 120 Oxamate, as inhib. of glycolysis 94 Noradrenergic fibers 120 N-Oxidation, amitriptyline 545, 547 Norchlorcyclizine 178, 521, 527-531 brompheniramine 535 action on hexobarbital metabolism 529 chlorcyclizine. HCl 530 action of liver supernatant on 528 chlorpromazine 539 action on zoxazolamine metabolism 529 cinnarizinc 531 14C, metabolic studies 530,531 hydroxY/ine 531 concentration, rat organs 529, 530 imipramine 547 fetal toxicity 531 Oxidative deamination, chlorpromazine, liver half-life, rat 528 microsom. syst. 539 metabolism, chronic treatment 529 orphenadrine 523 as metabolite of hydroxyzine 531 N -Oxides, as intermediates of AH metabolism of piperazines 527 521 teratogenic proper. 527,531 Oxime acetate 205 tissue protein affinity constant 529 Oxomemazine 446 Norcyclizine as metabolite of cyclizine 527, Oxyacid anion 256, 257 528 Oxygen consumption and hist. reI. 97,98,105 tissue affinity constant 529 Oxyntic gland mucosa, effects of gastrin on 48 Norepinephrine (see also Noradrenaline) 28, Oxyprocaine 463 163,458-460,462-464,468,470,472,582 Oxytocic agents 386, 389, 399,405 simi!. with hist. actions on g. pig ileum 457 Oxytocin 579 19-Nortestosterone 522 phenylpropionate 542 pA2 333-335,362 Nortriptyline 543,545 calculation 304 metabolic studies 543-546 correl. of AH and anticholinergics metabolism 545 414-416 Novalgin (aminopyrine analogue) 549 and local anesthetics 418 NSD-1024 48 with time of recovery 300 Nuclear magnetic resonance spectroscopy deduction 301 269,274,276,277 definition 334, 335, 391, 396 Nucleotide 279 determination 321,391,392 double reciprocal plot 394-396 Octopamine 153 logistic function 393, 394, 396 Octylamine 455,476 logit method 393 Oligomycin 100 matricial method 393, 394 effect on ATP, mast cells 101, 102, 104 effect of temperature 320 inhibition of hist. re!. by 101, 102 =log KB, measurement 178,180 Onium head 352 measurement in AH, reI. to atropine-like Oophorectomy 121 action 413 Opsonins 575 as parameter of affinity 303 Ornithine decarboxylase 111, 119 at receptor site 312,314,315,321,322,329, Orphenadrine 221,235, 516 396 N-demethylation 548 regression lines 320 rat liver microsomes 521 relation to pAx 302,313,391 Subject Index 691 pAz units, AH and AAch 416 inhibition by secretin 47 values (of AH) 215, 216, 218, 220-226, as stimulator of HDA 44 234-241, 243, 244, 310-314, 316, 319, Pentobarbital 4,5,6,8,14-19,562 320, 327, 336, 337, 339-341, 343-360, anesthesia and chlorcyclizine diet, rats 549 362, 364, 365, 382-385, 387-389, 390, metabolism, liver micros., action of 396,400,405 chlorcyclizine 550 of diphenhydramine, calc. from free potentiation by AH 562 energies 397,402 Pepsin secretion 53, 54 of enarttismorphs 385, 404 action of histamine 54 step by step linkage 243 of metiamide 54 steric influence 385,404 Peptide(s) basic, as hist. releasers 60 pA2/pD2 ratios, in cholinergic system biologically active, and compl. activation 349, 350 60 histaminergic system 345-348 cationic, as hist. releasers 60 pAx, definition 391 complement, as hist. releaser 60 determination 391 shock producing 576 indexes, definition and measurement leukotaxin 575 391-398 MDF 575, 576, 583 relation to pA2 303, 313, 391 VEM 575 values 251,304,316,319 vasoactive, as hist. releasers 60 at receptor site 318 Perazine 537 Pain, hist. as mediator of 417 metabolic studies 537,538 Papaverine 300, 304, 313, 453, 456, 457, 460, metabolites, rat 538 461,463,468 Perazyl (see also chlorcyclizine, Diparalene, Papillary muscle 10 Histantin, Trihistan) 384, 388, 398, 408 alterations in membrane and contraction Perigranular membranes 59, 79, 80, 82, 105 parameters 459 Periactin (see also Cyproheptadine) 300, 385, Paradryl (methbromide deriv. Benadryl) 182 443,450,467,468,473-476,506-510 Parameters of affinity 296, 303, 323, 328 Peripheral circulation, disorders 580, 581 Parasympathetic depressants and AH, in Permeability, cell membrane, changes 66, 79 anaphylaxis 463 and hist. reI. 59 Pargyline 163 changes 26 Parietal cells 43,47,48,50,54 of microvascular cells, action of hist. 113 and hist. receptor 51 Peroxidase method in degranul. studies 81 Partition coefficients, lipid: water 215 Perphenazine (Trilafon) 389, 537 octanol: water 231, 233, 360, 362 metabolites 538 burimamide 262 Pertussis vaccine 474 cimetidine 266 pfeiffer, rule of 351-353,355 metiamide 266 Pharmacological actions of AH 381 ff. thiaburimamide 263 receptors 295,296,301,328,329 Passive cutaneous anaphylaxis (see structure 295 Anaphylaxis, passive cutaneous) Phenacetin 163 Passive sensitization as AH assay 411 Phenbenzamin (see also Antergan 2339 RP) mechanism 60,61 181,218,240,338,345,445,448-450,470, Pav-atrine 415 471 pC, local anesthetics, correl. pAz of AH 418 class, as forerunners of AH 179 pD2 333, 334, 336 Phenergan (see also promethazine; values 337, 339, 340, 344, 352, 364 diprazinum, Tergigan, 3277 RP) 196, 300, pD2 333, 335, 336, 341, 362 306, 308, 381, 388, 389, 398, 401, 407, 410, values 337,339,341,343,345-351,353-362 415,417,418,421 Penicillin conjugates, cut. anaphylaxis by 535 Phenindamine (see also Thephorin) 178, 342, Pentagastrin 45,46,48,53, 112,259,264,265 381,384,388,398,408,415,418,420,447, and ac. gastr. secr. 48 449,474,508,510,590 acetylcholine in 50 absorption, rate 516 effect of atropine 52 action on CNS 564 burimamide 49 concentration in rat tissues 516 metiamide 49, 50, 52 excretion 516 692 Subject Index

Phenindamine metabolic studies 516 of orphenadrine 552 metabolism, early studies 515 test, dog 549, 550 pKa 177 Phenylephrine 463 Pheniramine(s) (3-amino-l-aryl-l-(2-pyridyl• Phenylethylamine 153, 338, 344 propanes, Trimeton) 183-186, 193,242, Phenylmagnesium Br 184 381,408,415,418,447,448,449,532 I-Phenyl-1-(2-pyridyl)-3-N- action on CNS 564, 565 dimethylaminoprop-l-ene 384 chiral center 225 1-Phenyl-l-(3-pyridyl)-3-N - configuration 195, 196 dimethylaminoprop-1-ene 385 duration of action 193 I-Phenyl-1-(4-pyridyl)-3-N - effect on EEG 565 dimethylaminoprop-l-ene 385 enantiomers 194 I-Phenyl-1-(2-pyridyl)-3-N - hypnotic effect 564, 565 pyrrolidinoprop-1-ene 385 local anesthetic action, g. pig skin 194 I-Phenylpyrrolidine derivatives 204 optical isomers 194 Phenyltoloxamine, action on CNS 564 pA2 415 Phosphatidyl inositol 63 pKa 177 serine and desensitization 66 pKB 194 and histamine release 62, 63, 68 protection against hist. action, g. pig 194 anaphylactic 99 stereoconfiguration 184, 185 effect on Ca 65 D-Pheniramine (D-Trimeton) 193, 383, 388, by antigen, dextran 100, 101 404 and PCA reaction 63 DL-Pheniramine 226 in platelet amine release and aggregation L-Pheniramine (L-Trimeton) 383,388,404 68 Phenobarbital 522 and systemic anaphylaxis 63 induction liver N -demethylase, sev. AH 542 Phosphodiesterase inhibitors 165, 167 Phenol 371 inhib. of hist. reI. by 61 Phenothiazine derivatives 176, 196-198, 303, Phospholipid protein complex (cell membr.). 384,389,405,413,417,520,537,588 227 as antiallergic and psychotropic agents 537 Phospholipids, in mast cells 78 chemical structure 196 Physostigmine, antagonism with AH, in CNS 2,7-diazo 180 567 dipole moment 230 2-Picolinic acid 184 lO-haloalkyl 197 Picric acid reaction, for AH metabolic pA2 values 197 studies 513-515 sedative effects 197, 198 Pilocarpine 163,416 synthesis 197 Pinocytosis 106 Phenoxybenzamine (see also Dibenzyline) Piperazine derivatives 384, 588 163,302,314-321,323,324,390,397,578 action on CNS 564, 565 as competitive H1-antagonist 397 hypnotic effect 564-566 complex form. with H l-receptors, effect of sedative effect 565 temp. 320-322 Piperidine derivatives 384 Phenoxyethylamine 382, 386, 405 ring 181, 182 Phenoxy-propanediols, metabolic studies 2-( l-Piperidino-methyl)-1,4-benzdioxan 215 535-537 Piprinhydrinate 473 in cut. anaphylaxis 535 (I131)_Pipsyl anhydride 153 Phentolamine (see also Regitine) 464 Pipsyl derivatives 152 Phenylalanine 404 Piriton (see chlorpheniramine) N-Phenyl-N-benzyl-fJ-aminoethyl pKB values, under equilibrium conditions derivatives of hist. 344 387-389, 396 N -(N'-Phenyl-N'-benzyl-fJ-aminoethyl)-N• Placenta, effect of sex hormones 119 methyl [2-(fJ-aminoethyIJ)-pyridine, hist. in, golden hamster 119 molecular modif. 355 perfusion 20 N-Phenyl-N-benzylethylamine group, Platelet(s) 510 molecular modif. 354, 355 aggregation 68 Phenylbutazone 163,474,509,510,551 action var. substances 68 metabolism, infl. of chlorcyclizine 529 and amine release 68 Subject Index 693

Platelet(s) effect on EEG 566, 569 inhib. by colchicine 68 hypnotic effect 566 histamine release from 67,68 increase and reduction in REM sleep 569 simil. with mast cells 67 lack of correl. with AH effects (on CNS) 569 segregation 467,468,470 metabolic studies 538-543 Plethysmography 410 in obstetrical patients 566 photoelectric 411 pA2 197 PMR spectra 190,191 pK. 177 Polaramine (see also D-chlorpheniramine, ~olar metabolites 539 D-Chlortrimeton) 195, 384, 404, 409, 420 5S, in metabolic studies 538, 539 Polaronil (see chlorpheniramine) compar. with Aprobit 539, 540 Polycythemia 142 sulfoxide 539 Polylysine 163 synthesis 197 as degranul. agent 78 theoclate (see also A vomine), anti-emetic and Polymorphonuclear leukocyte (PMN) motion sickness effects 196, 197 infiltration 509 Pronethalol (see also Propranolol) 400 Polymyxin B 471,476 Propanolamines, as AH 588 as degranul. agent 78 Propantheline 398 Polypeptides 582 Properdin 575 bradykinin-type 386 Propranolol (Pronethalol) 62, 163, 400, 460, in shock 583 463,464,466,472 Polyphloretin phosphate 509 Propylamines 227,383,384 Postafen (see also Meclizine, meclozine) 388 Prostaglandin(s) 89, 422, 443, 477, 506, 507, Potassium (ions) 58,79,582 509, 582, 584 agonist in trachea 509 Al 28 in hist. release 106 E 444,466 levels in plasma 468 EI 64,66,68,474,506,507 Posterior pituitary hormones 579 stirn. of HD by 45 synthetic analogs 579 E2 460,506,507,509 Potential well 309,311 F2• 28,444,454,460,472,477,509 Praomys ( M astomys) natal ens is 110 antagonists 27 Prazepine 201 biosynthesis, inhibition 507,510 Precapillary sphincter 24, 25 role in carrageenan edema 507 Precipitin titer, action of AH on 442 derivatives (fatty acids) 584 Prednisolone 464, 508 as inhibitor of hist. reI. 61, 64 Pressure-resistance-capacitance 578 as modulator of anaphylactic hist. reI. 443 rhinometry 411 peroxide 460 Privin 300,313 release 509 Procaine 300,304,313,417-420,463 anaphylactic, action of AH 443,444 pA2 418 by anoxia 584 Prochlorperazine 389, 537 histamine as mediator of 443 metabolic studies 537,538 by ischemia 584 metabolites 538 in shock by endotoxin 584 Progesterone 29, 119 hemorrhagic 584 Promazine (3276 RP) 228,300,313,388,475, -like conditions 584 589,590 synthetase inhibitors 584 Promethazine (see also Phenergan, Lergigan, synthesis, in early shock 584 3277 RP) 2, 176, 177, 196, 342, 381, 388, inhibitors 584 389,398,401,407,410,415,417,418,421, Prosympal (883 F) 386, 405 508,510,537,538,540,541,590,592 Protein(s), contractile, in hist. reI. 59, 106 action on CNS 538, 564, 566 in granules 87,88 in allergy 538 in mast cells 78 analogues 401,440 synthesis 111 anti-H2 actions 440, 441, 443, 446-449, inhibitors of 114 451,453,457,458,467,469-477 Proteolysis 583 comparison with barbiturates 569 Protracted shock, anaphylactic 445,451,461, daytime sedation 564 469,478,479 694 Subject Index

Protracted catecholamine release and action potent. of sedation 562 of AH 464,479 Pyronil (see also pyrrobutamine) 185, 188, Protriptyline 543 388 N-demethylation 545,546 Pyrrobutamine (diphosphate) 187, 188, 194, metabolic studies 543-546 238,388,448 metabolism 545 bases (pK b) 188 metabolites 545, 546 derivatives 188, 189 Prozapine 226 dosage 188 Puromycin 118, 119 Pyrrolazote (see pyrathiazine) Putrescine 163 3-N -Pyrrolidinopropenes 241, 242 excretion 119 Pyruvate 104 Pyrabrom (pyrilamine 8-bromo theophyllinate), action on CNS 564 QSAR 333 Pyrathiazine (pyrrolazote) 197,388,447,450, of 2-(p-aminoethyl)-pyridines 360--362 537, 589, 590, 592 integrated 404 action on CNS 564 studies 364 pKa 177 Quinidine 461 Pyribenzamine (see also tripelennamine) 381, -like substances 461 383,387,398,401,407,410,412,415,417, 420,443,447-451,454-456,458,462,468, Rabbit-aorta-contracting substance 460 469, 474, 476, 477, 508-510, 513, 515, Radiochromatographic microassay for 589-591 histamine 110 14C-benzyl methylene, metabolic studies Ragweed antigen 164, 167 524,525 E 63 rate of elimination 525 Rat, circulatory shock 581 elimination, man 514,515 Rate theory 326, 327 metabolic studies 523-526 Reactive hyperemia, effect of AH 441,442 cyanogen bromide assay 514 hist. mediation 386 methyl orange technique 520, 521, 524 Reaginic antibodies 64 metabolites 525, 526 IgE 93 pA2 180 Reagin-like antibodies 473,474 tissue distribution 523, 524 Receptor(s), for acetylcholine (muscarinic) Pyridoxal 117 260,326,350,424 phosphate 109, 116, 117, 169 adrenergic 424 as HD coenzyme 113 action of AH 390 role of 122 affinity for (see Affinity) trapping agents 117 for agonist 344, 345 1-(2-Pyridyl)-I-(4-Cl-phenyl)-3-N - -agonist relationship 333 pyrrolidinoprop-l-ene 385 "annex" part 296,297,299, 301, 310, 326, 2-(2-Pyridyl)ethylamine 251 327, 329 2-Pyridyllithium 189 hydrophobic binding 296,310,311,315, 1-(2-Pyridyl)-I-(4-methyl phenyl)-3-N -pyrro- 319,320,322 lidinoprop-l-ene for antagonist 344 (see also Tripolidine) 385, 388 -antagonist complex 296-299,301,303, 2-Pyridyl-pheniramines 225 312 1-(2-Pyridyl)-I-phenyl-3-N -dimethyl amino• relationship (interaction) 333, 350, 351 prop-l-ene 384 areas, additional 342-345, 364 1-(2-Pyridyl)-I-phenyl-3-N -pyrrolidinoprop• hydrophobic forces 346 l-ene 385 binding forces 311,312,350 Pyridyl-2-thioacetamide 510 site, metactoid 362 Pyrilamine (see also Neoantergan, mepyr- _. specific 362 amine, Anthisan; 2786 RP) 375,381,383, blockade 345 387,389,398,399,405,407,412,413,415, {3, for catecholamines 400, 462 417,418,421-424,444,446-455,458,459, cholinergic 296 461-478,506-510,591,592 action of AH 390 action on CNS 591,592 and lipophilicity of antagonist 362 8-bromo-theophyllinate (Pyrabrom) 564 complementarity 346-348,350 Subject Index 695

Receptor(s), complex formation 296,297, equation 304, 305, 310 299,301,310,311,320,328 calculation for AH 306, 307 Arrhenius plot 322 fit with exptl. data 307-309 enthalpy 332 reI. to pA2 308 entropy 322 theoretical calc. 306,307,309 drug combination (complex) 296, 328 index 300 effector system(s) 333, 334, 345 kinetics 299ff., 314, 326 "fit" 350 microphysical model 309 for histamine 341-345,348,381 parameter 305, 312 and acetylcholine, structure 414 percentage 305,306,308-310 "annex" part 390, 402 process 300,301,312,314,317 interaction with agonist 342 345 effect of temperature 301,314,315, with competitive antagonists 342-345 317-320 HI-receptor 252, 260, 326 rate 328 H2-receptor, definition 253 time 299,311-313 identification 251,252 acetylcholine vs. atropine 299 model 385 and AH potency 300,312 second anchorage group 381 changes in 301 specific 1, 2 correl. with pA2 300,312,321 specific part 390 RDS (reticuloendothelial depressant substance) vascular 24 575 histaminergic 296 Reduction, p-nitrobenzoic acid 521 inactivation 328 Reflex vasodilatation 23 intrinsic activity (see Intrinsic activity) Regitine (Phentolamine) 300, 304, 313, 464 kininergic 424 Regression 260 metactoid (non-competitive) 333, 335, 348, AH vs. Mch 416 350, 355, 362 AH vs. local anesthetics 419 affinity 363 analysis 218,220,221,225,231,236,238, number 304 356-360, 363 pharmacologic 295,296,301,328,329 physicochem. constants 356-360 structure 295 equation 216,229, 232, 233, 239, 240, 244, reserve 344, 352, 364, 365 259 site 296,297, 301, 310, 322, 328 multiple 233 anionic 256 liners) 300 charge transfer 302 pA2 321, 322 covalent bonds 302, 320, 322 Renin 583 hydrophobic interactions 302 RES (reticulo-endothelial system) 582 ionic bonds 302, 322 stirn. by hist. 423 occupancy 278 in PCA 423 pA2 at 312,314,315,321,322,329 Reserpine 112,374,378,471,473,475,551 topography 301 effect on brain hist. 120 van der Waals interactions 302 Reserpinization, effect in anaphylactic shock spare 299, 300, 322, 324, 397 470, 471 specific 348, 351,362 acute 462 for IgE 61 protracted 464 for hist. reI. 57, 59 Resistance, air flow, measur. 410 interaction with hist. releasers 59,68 respiratory, total measur. 410 part 296,297,320 Respiration, and anaphylactic hist. reI. 97 structure, hypothetical 424 Reversed anaphylaxis, ATP content of mast system in atria and ventricles 458,459 cells in 105 dual, for histamine 454 Rhodanine 116 topology 390 Rotating drum trauma (see also Noble-Collip triptaminergic 424 drum) 112 Recovery, after competitive AH (g. pig ileum) Rotenone 94 298, 299 Rothmund-Kornfeld equation 86, 87 curves 299,304,307-309,317,318 Rous rat sarcoma III double exponential 2325 RP 383, 387,407 696 Subject Index

2339 RP (see also Antergan, phenbenzamine) Sarcoplasmic reticular and mitochond. bin- 381,383,387,389,398,399,405,407,417, ding 30 421 se 15396 (antigastrin) 45 2786 RP (see also mepyramine, pyrilamine, se 19220 509 Neoantergan, Anthisan) 381,383,387,389, Sch 15280 410 399,405,407,412,413,415,417,418,421-425 Schultz-Dale reaction, isolated ileum 455 2971 RP (see also Hetramine) 381,383,408 pulmonary vein 476 2987 RP (see also Diethazine) 389 Sclerosis, multiple 8 3015 RP 389,405,407,417 Scopolamine 381 metabolic studies 520, 521 action on eNS 567 3276 RP (see Promazine) inhib. of AH 567 '3277 RP (see also promethazine, Phenergan; elTect on EEG 567 Lergigan) 381,388,389,398,401,405,407, inhibition by atropine 567 410,415,417,418 Seasickness and action of AH (see also indi• 3300 RP 389 vidual compounds) 411 3356 RP 389 Secobarbital 564, 565 3554 RP (see also Multergan) 389,415 comparison with AH elTects 564, 565 4560 RP (see chlorpromazine) Secretagog-acid response, dose-response curves 46, 47 Secretin 582 S-Adenosylmethionine (see S-Adenosyl• action on HDA 48 methionine) inhibition of pentagastrin response by 47 Salivation, parasympathetic, hist. mediation of Secretion of granules, from mast cells and hist. 111 reI. 58 Sandostene (see Thenaldine) Sedative activity, Benadryl 182 SAR (structure-activity relationship) 333, diphenhydramines 231 364, 398, 513 (see also individual compounds) Free and Wilson model 231,232 Selye pouch 516 Hansch approach 216,231-234 Semicarbacide 117 Hansch model 231 35 S-Semicarbazide 153 H I-receptor antagonists 2151T. Sensitization, adrenergic, by AH 462, 463 amino alkylethers 219 Sepsis 577, 578 aza-diphenhydramine derivatives 225 Serine esterase, and hist. reI. 59 biological activity center (BAC) 229,230 diphenhydramines 220-225 Serotonin (5-HT) 27, 175,423,443,454,455, Hansch approach 232, 233 466,468,470-479,505-510,575,582,583 dipole moments 230, 231 aerosol 466 effect of charge localization 229, 230 antagonists (antiserotonins) 175,583 ethylenediamines 216-218 14e, granules charged with 85 pA2 values 216-218 in circulatory shock 583 integrated QSAR studies 240-244 and degranul. of mast cells 88 and metabolic studies 522 increase vasco permeability by 583 2-methyldiphenhydramine derivatives intracellular release 88 220 in mast cells 75, 78 nonspecific elTects 228 and NAS action 369,370,375, 376, 378 pA2 values 215,216,218,220-226, physiological action 583 235-238 release by cation exchange 88 physical proper. and anti-HI act. 227, by ischemia and anoxia 583 231 from mast cells 58 quantitative comparison 215 from platelets 67 stereospecificity 234 in portal circulation 583 UV and IR spectra 228 role in carrageenan edema 507 Hrreceptor antagonists 251 IT., 277 sensitivity 466 pitfalls 363-366 storage in granules 75, 85 practical studies 231 thrombus formation by 583 quantitative, integrated 240-244 turnover in brain 120 Sarcoma, virus induced 110 Serotoninergic fibers 120 Subject Index 697

N I-DL-Seryl)-N 2-(2,3,4-trihydroxybenzyl) tourniquet 164,166,167,440,492 hydrazine (Ro 4-4602), inhibitor ofHD 121 by toxins 386 Sex hormones 29,30, 119 traumatic 386 Shock, by acute pancreatitis 583 action of AH on mortality 592 anaphylactic (see also Anaphylactic shock, in diff. species 592 Anaphylaxis) 441,446-450 by muscle crush 592 action of AH 409-412,446-450 vasoconstriction, compensatory in 580 acute, action of AH 445,451,472,478, by venoms 386 479 Sigma (J+ constant (Brown and Okamoto) catecholamine release 461-464,479 229 protracted, action of AH 445,451,461, Single isotope assay (for histamine) 152, 153, 469,478,479 161, 164 catecholamine release 464,479 assay blanks 162, 163 II-hydroxycorticosteroid levels 464 calculation 162 role of corticoids 464 conditions for 158 by anaphylatoxin 452,478 diff. procedures 165 burn 164,166,167,386,440 interference 163, 164 capillary circul. in 580 microassay 164 clinical therapy of 577,578 modification 164 by dextran 164, 165 precision 162, 163 by endotoxin 164, 166, 167,440 specificity 162 by hist. and action of AH 446-450, 452, standard curves 159 468 SKF -525 A (f3-diethylaminoethyl diphenyl• mechanism of 386 acetate) 522, 527, 539, 542 microcirculatory system in 580 Skin vessels, action of AH 420-423 microvessels in 577 Sleep evaluation methods, by EEG records by Noble-Collip drum 592,593 565 organ, coronary vessels 456 by REM sleep period 565 g. pig 410 Smooth muscle vasco 575,581 heart 456 Sodium, azide 281,518 small intestine, rat 471 bromide 551 peripherial circulation in 580 carbonate 182 phases 578, 580 cromolyn (see also cromoglycate) 468 polypeptides in 583 cyanate 398 producing substances, acetylcholine 575 cyanide 518 adenyl compounds 576 fluoride 518 blood borne agents 576 role in degranulation 87 catecholamines 575 uptake by mast cell granules 86, 87 complement 575 urate 508 ferritin 575 Softram (see also Buclizine) 185, 388,448 histamine 575 Soventol (Bamipine) 181,409,415 lactic acid 576 "Spare" receptors (see also Receptor(s), space) metabolites 576 397 opsonins 575 Spasm, by barium 444, 456 peptides 576 Spasmolytics 451 properdin 575 "Specific" part of receptor (histamine) 297, serotonin 575 298,301,327,390,402 thiols 575 competition for 296,315 VDM 575 Specific receptors (see also Receptor(s), role of kinins 583 specific) 348,351,362 of toxic substances 577 Spectral data and anti-H 1 activity 228 systemic 463,466 Spermidine 151, 163 target organs 577 SRS-(A) (Slow reacting substance) 89,413, termin. vasco bed 580 443,444,472,476,477 therapeutical aspects 577fT. antagonists 453 pressor agents 577,579 formation, inhibition of 443,466,472 vasoactive agents 577-579 release, anaphylactic 460 698 Subject Index

SRS-(A) 2.2', 6.6'-Tetramethyl-diphenhydramine 228 effect of hist. 440 Thenaldine (Sandostene) 181,450 inhibition of 473 Thenfadil (see also Thenyldiamine) 442 Starch 412 Thenyldiamine 442, 473 Starling heart-lung preparation (see Heart- action on CNS 564 lung preparation) Thenylene (see also methapyrilene, Histadyl) Stelazine (see also trifluperazine) 389 381,383,387,398,408,415,420 Stereochemistry of AH 189,190 Theophylline 163,401,474 Stereospecificity of AH 234-239 and hist. reI. 61,62,66 Steroid(s) 377, 378 Thephorin (see also phenindamine) 381, 384, hormones 29 388,398,408,415,418,420,447,449,474, hydroxylation and action of chlorcyclizine 508,510 551 absorption rate 516 p-Stimulants 474 action on Hrreceptors 203 Stovaine (amilocaine, HCl) 417,418,463 chemistry and synthesis 203, 204 Strontium and hist. reI. 65 comparison with diphenhydramine 203 Structure-activity relationship (see SAR) tripelennamine 203 Stugeron (see also Cinnarazin, cinnarizin) triprolidine 203 185 concentration in rat tissues 516 Substance P 576 derivatives 203 as degranul. agent 78 excretion 516 Succinate 95 metabolic studies 516 Sulfhydric acid (H S) 518, 554 2 metabolism, early studies 515 Sulfhydryl reagents 59 potency 203 Sulfoxidation, Aprobit 540 chlorpromazine 539 Thermal injury 510 dimetotiazine 541 Thiaburimamide 261-264 fenethazine 543 crystalline structure 273 isothipendyl 543 partition ratio 280 methdilazine 540 Thiazol-4-ylmethoxamine (TMA) 116 metiamide 553, 554 Thiopental 16 promethazine 539 -chloralose 6, 8 trimeprazine 543 Thiourea(s) as AH 588 Sympathetic blocking (sympatholytic) bond length and angle 277 agents 112,389,399 bond rotation 277 C( and P 326 chemical proper. 285 C(, AH as 424 configuration of N-substituents 268 P 400, 405 conformational isomerism 277 Sympathomimetic amines 462,466 dipolar structure 268 (C()Sympathomimetics 468, 509 N, N'-disubstituted 268,269 Synaptosomes 121 free energies of activation 277 Synopen (see also chlorpyramine, chlorpyri• geometries 277 benzamine) 381,383,408 groups 272,273,279 imidazol contacts 271 Taft parameter 231-233,239,240 intraversion of isomerism 277 Tagathen (see also chlorothen, chlorpyriline) physicochem. proper. 266,267,274 383,387,408,415,420 prototropic equillibria 268 "Target pharmacology" 296 similarity with cyanoguanidines 277 Tarpan 202, 446 toxicity 554 Tastromine 382, 386, 399, 405, 407 Thioxanthene 198 Tavegil (HS-592), metabolism 523 Thiozinamine (methyl sulfate) 410 Tavegyl (see also cyclizine) 388 Thonzylamine (see also Neohetramine, Teldrin (see chlorpheniramine) Anahist) 180,381,383,408,415,418, Tenuazonic acid 118 447,449,450,451,454,456,468 Testosterone 119, 138 structure 180 hydroxylation 551 Thorazine (see chlorpromazine, Largactil, Tetracaine 418,419 Amplictil) Subject Index 699

ThrombIn, in platelet amine reI. and aggrega• solvent partitions and extractions 526 tion 68 conjugation with glucoronic acid 526 Thromboxane A2 460 N-demethylation 526 Thymoxyethyldiethylamine (929 F) 382, effect on EEG 563, 565 386,387,389,399,405,409,417 elimination 514, 515 Thyroidectomy 121 hydroxylation 526 Thyroxine 119 hypnotic effect 564 Tissue injury, hist. reI. in 167 metabolic studies 514,515,520,521,524 Tofenacine, HCl 236 metabolism 523-526 Toladryl (Neobenodine) 388 metabolites 525, 526 3sS-Toluene sulfonic acid anhydride pKa values 177 eSS-tosan) 153 quaternary methyl iodide, distrib. and p-Toluenesulfonyl hydrazine (PTSH) 117 excretion 526 Toluidine blue, as degranul. agent 78 sedative actions 564, 565 as metachromatic stain 79, 88 structure 180, 182, 184 Toxins 386 tissue distribution, rat 523, 524 bacterial 386 Triple response (Lewis) of hist., in skin shock producing, endotoxin 575 420, 421 Fakuda's factor 575 action of AH 421 hemochromogen 575 Triprolidine 475 RDS 575 Triprolidine (1-(2-pyridyl)-I-(4-methyl- TPNH-oxidase 551 phenyl )-3-N -pyrro1idineprop-l-ene; Trasylol (aprotinin) 475 Actidyl) 176,204,238,385,388,448,451, Trauma 577, 587 467,510 Tribenoside (Glyvenol) 448,474 effect on Ilare and wheal by hist. 564 Tribromethanol 562 correl. with AH effect 569 Tridipigen 475 pKB values 191,192 Trilluopromazine 389 PMR spectra of isomers 190,191 N -[2-(2-Trill uoromethyl-phenothiazinyl-l 0) stereoconfiguration 190, 192 propyl] diethylene, diamine 538 stereoisomers 190 Trilluperazine (Stelazine) 389, 537 Triton X-100, effect on ac. secretion and hist. metabolic studies 537, 538 reI. 48 metabolites 538 Tritoqualine (554-L) 116 Trihistan (see also chlorcyclizine, Perazyl, decarboxylase inhibitor 467 Diparalene, Histantin) 384, 388, 398, 408 Tromexan 551 Trilafon (see Perphenazine) Trypsin 322 Trimeprazine 197, 537 in platelet amine release and aggregation N -demethylation, liver, var. species 521, 68 542, 543 Tryptamine 153 differential metabolism, liver, var. species Tryptophan-deficient rats, HDA in liver 110 542, 543 TSH 119 metabolism, mice 522 T. spira lis infection 474 N-oxide 543 serum 466 Trimeton (see also pheniramine) 193,381, Tuberculin reaction 1\0 408,415,418,447-449 (d-)Tubocurarine 456 L-Trimeton (see also L-pheniramine) 383, as degranul. agent 78 388, 404 urethane 8 Tripelennamine (see also Pyribenzamine) Tyramine 462 182, 184,218,381,383,387,398,401,407, Tyrode's soln., composition 334 410,412,415,417,420,443,446-451, 454-456,458,462,468,469,474,476,477, Ultrasonication, mast cells 80 508-510,513,515 UML 471 14C-benzyl methylene, metabolic studies Urea 554 524 Urecholine, action on pepsin response 54 14C-balance 525 stimulated ac. secretion, inhib. by meti• metabolism 525 amide 49 rate of elimination 525 stimulus for HDA 43 700 Subject Index

Urethane 4,8,11, 16-18,462 peptides, as degranuI. agents 78 Urocanic acid 163 Vasodilation, reflex 23 Urticaria 143, 164, 389,421 Vasopressin 576,579, 582, 583 action of AH 421 clinical exper. with 579 Uterus, effect of antagonist on hist., action VEM 575 263 Venoms 386 inhibition by hist. 252 animal 386 by histamine-like compounds 253 Ventricular strip 10 UV lesions 510 Vibration energy 310 spectroscopy 187, 190, 191 Vinylyc chemical shift (simplet, triplet) 187 proton 186, 187 Vagal stimulation, of gastric (ac.) secretion resonance 186, 187 42,43,54 2-Vinylpyridine 190, 191 release of gastrin by 44 Vagotomy 112,472 Walker (rat) mammary carcinoma 110, 111 action on HDA 44 Waller ian degeneration 120 effect on gastric (ac.) secretion 44 Wilcoxon's signed rank test (two-tailed) 351 Van der Waals forces 402 interactions (at recepter site) 302,319 volume 358,36G-362 Xanthene derivatives 198 Vascular permeability 509 X-ray diffraction 182, 196 action of AH 42G-423 Xylometazoline 509 microscopic observ. 423 regulation by hist. mediation 386 Yohimbine 381 test, in animals 422,423 blue test for AH potency 422 Z(zusammen) = trans 186, 187 radioisotope test 423 Zinc-albumin 452, 453 reactivity 30 in granules 84 syndrome, by Forssman antibodies 468 chelation by hist. 84 Vasoactive agent(s) 575ff. determ. by activation analysis 84 angiotensin 583 Zolamine 180, 447 antagonists 579 structure 180 drugs as 578, 579 Zoxazolamine, effect of diphenhydramine on endogenous 580. action of 555 histamine 575 metabolism, infl. chlor- and norchlorcyc• low flow states 577, 578 Iizine 529 pressor amines 579 liver microsomes, action of chlorcyclizine renin, kidney 583 550 in shock therapy 577, 578 and paralysis, action of orphenadrine vasomotor activity 578 552 Volume 76 Reviews of Physiology, H. Hilz and P. Stone: Biochemistry Poly (ADP-Ribose) and ADP-Ribosylation of Proteins and Pharmacology W.Wuttke: formerly Neuroendocrine Mechanisms in Reproductive Ergebnisse der Physiologie, biologischen Physiology Chemie und experimentellen Pharmakologie F. Ellendorff: Editors: R. H. Adrian, E. Helmreich, H. Holzer, Evaluation of Extrahypothalamic Control of R. lung, K. Kramer, O. Krayer, R. 1. Linden, Reproductive Physiology F. Lynen, P. A. Miescher, 1. Piiper, H. Ras• A. M. Rappaport and 1. H. Schneiderman: mussen, A. E. Renold, U. Trendelenburg, The Function of the Hepatic Artery K. Ullrich, W. Vogt, A. Weber Volume 77 This series presents rapid and comprehensive K. Starke: information on topical problems and research Regulation of Noradrenaline Release in progress over the entire range of physio• by Presynaptic Receptor Systems logy, biochemistry, and pharmacology. P. Ward and E. Becker: An international group of editors is respon• Biology of Leukotaxis sible for inviting experts in these fields to W. A. Grunewald and W. Sowa: submit contributions. Every year three to four Capillary Structures and O2 Supply to Tissue volumes are published. The language of Volume 78 publication is English. B. Deuticke: Properties and Structural Basis of Simple Volume 73 Diffusion Pathways in the Erythrocyte W. Hassel bach: Membrane Hans Hermann Weber, 1896-1974 R. K.Crane: E. de Robertis: The Gradient Hypothesis and Other Models Synaptic Receptor Proteins. Isolation and of Carrier - Mediated Active Transport Reconstruction in Artificial Membranes A. Melander, L. E. Ericson, F. Sunder and Volume 79 U. Westgren: 1. M. Ritchie, R. B. Rogart: Intrathyroidal Amines in the Regulation of The Binding of Saxitoxin and Tetrodotoxin Thyroid Activity to Excitable Tissue 1. Haase, S. Cleveland and H.-G. Ross: K. Sato: Problems of Postsynaptic Autogenous and The Physiology, Pharmacology, and Recurrent Inhibition in the Mammalian Biochemistry of the Eccrine Sweat Gland Spinal Cord G.Sachs: I. S. Kulaev: H Transport by Non-Electrogenic Gastric Biochemistry of Inorganic Polyphosphates ATPase as a Model for Acid Reaction Volume 74 F.E.Bloom: The Role of Cyclic Nucleotides in Central Synaptic Function S. Silbernagl, E. C. Foulkes and P. Deetjen: Renal Transport of Amino Acids Volume 75 E.Hofmann: The Significance of Phosphofructokinase to the Regulation of Carbohydrate Metabolism Springer-Verlag H. Grunicke, B. Puschendorf and H. Werchau: Mechanism of Action of Distamycin A and Berlin Other Antibiotics with Antiviral Activity Heidelberg A. E. Lambert: The Regulation oflnsulin Secretion New York Handbuch der experimentellen Volume 37: Pharmakologie / Handbook Angiotensin Volume 38: Part 1 of Experimental Pharmacology Antineoplastic and Immunosuppressive Agents I HetTter-Heubner, New Series Part 2 Antineoplastic and Immunosuppressive Agents II Volume 23: Volume 39: Neurohypophysial Hormones and Similar Antihypertensive Agents Polypeptides Volume 40: Volume 24: Organic Nitrates Diuretica Volume 41: Volume 25: Hypolipidemic Agents Bradykinin, Kallidin and Kallikrein Volume 42: Volume 26: Neuromuscular Junction Vergleichende Pharmakologie von iibertriiger• Volume 43: substanzen in tiersystematischer Darstellung Anabolic-Androgenic Steroids Volume 27: Volume 44: Anticoagulantien Heme and Hemoproteins Volume 28: Part 1 Volume 45: Concepts in Biochemical Pharmacology I Drug Addiction I and II Part 2 Concepts in Biochemical Pharmacology II Volume 46: Part 3 Fibrinolytics and Antifibrinolytics Concepts in Biochemical Pharmacology III (in preparation) Volume 29: Volume 47: Oral wirksame Antidiabetika Drug-Reception Inactivation (in preparation) Volume 30: Volume 48: Modern Inhalation Anesthetics Arthropod Venoms Volume3l: Volume 49: Antianginal Drugs GanglioniC Transmission (in preparation) Out of print Volume 50: Volume 32: Part 1 Inflammation and Anti-inflammatory Drugs Insulin I (in preparation) Part 2 Insulin II Volume 33: Catecholamines Volume 34: Secretin, Cholecystokinin-Pancreozymin and Gastrin Volume 35: Part 1 Androgene I Part 2 Springer-Verlag Androgens II and AntiandrogenslAndrogene II Berlin und Antiandrogene Heidelberg Volume 36: Uranium-Plutonium-Transplutonic Elements New York